Kavita M Dhodapkar, Sharon Castellino, Shivani Kapadia, Maryam I Azeem, Ava Horvat, Taylor Lawrence, Deborah DeRyckere, Madhav V Dhodapkar
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Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors.
We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.
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