npj aging最新文献_第10页

Mitochondrial function in peripheral blood cells across the human lifespan. 人一生中外周血细胞的线粒体功能。

npj aging Pub Date : 2024-02-07 DOI: 10.1038/s41514-023-00130-4

Johannes K Ehinger, Emil Westerlund, Eleonor Åsander Frostner, Michael Karlsson, Gesine Paul, Fredrik Sjövall, Eskil Elmér

引用次数: 0

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment. 衰老剂：从药理抑制剂到免疫疗法，患者治疗的美好未来。

IF 4.1

npj aging Pub Date : 2024-02-06 DOI: 10.1038/s41514-024-00138-4

V Lelarge, R Capelle, F Oger, T Mathieu, B Le Calvé

{"title":"Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.","authors":"V Lelarge, R Capelle, F Oger, T Mathieu, B Le Calvé","doi":"10.1038/s41514-024-00138-4","DOIUrl":"10.1038/s41514-024-00138-4","url":null,"abstract":"The involvement of cellular senescence in the initiation and propagation of diseases is clearly characterized, making the elimination of senescent cells essential to treat age-related diseases. The development of senolytic drugs demonstrated that targeting these cells limits the deterioration of patients' condition, by inducing apoptosis. Nevertheless, the first generations of senolytics which has been developed displayed their activities through specific mechanisms and demonstrated several limitations during clinical development. However, the rational to eliminate senescent cells remains evident, with the necessity to develop specific therapies in a context of diseases and tissues. The evolutions in the field of drug discovery open the way to a new generation of senolytic therapies, such as immunological approaches (CAR-T cells, Antibody-Drug Conjugated or vaccines), which require preliminary steps of research to identify markers specifically expressed on senescent cells, demonstrating promising specific effects. Currently, the preclinical development of these strategies appears more challenging to avoid strong side effects, but the expected results are commensurate with patients' hopes for treatments. In this review, we highlight the fact that the classical senolytic approach based on drug repurposing display limited efficacy and probably reached its limits in term of clinical development. The recent development of more complex therapies and the extension of interest in the domain of senescence in different fields of research allow to extend the possibility to discover powerful therapies. The future of age-related diseases treatment is linked to the development of new approaches based on cell therapy or immunotherapy to offer the best treatment for patients.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"12"},"PeriodicalIF":4.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the past, present and future of senotherapeutics. 关于老年疗法的过去、现在和未来。

npj aging Pub Date : 2024-02-03 DOI: 10.1038/s41514-024-00139-3

Marco Quarta, Marco Demaria

引用次数: 0

A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging. 多柔比星诱发心脏毒性和衰老的病理生理机制综述。

IF 4.1

npj aging Pub Date : 2024-01-23 DOI: 10.1038/s41514-024-00135-7

Annet Nicole Linders, Itamar Braga Dias, Teresa López Fernández, Carlo Gabriele Tocchetti, Nils Bomer, Peter Van der Meer

引用次数: 0

Attitudes and barriers towards deprescribing in older patients experiencing polypharmacy: a narrative review. 多药合用的老年患者对取消处方的态度和障碍：叙述性综述。

IF 4.1

npj aging Pub Date : 2024-01-23 DOI: 10.1038/s41514-023-00132-2

Michael Robinson, Sophie Mokrzecki, Andrew J Mallett

{"title":"Attitudes and barriers towards deprescribing in older patients experiencing polypharmacy: a narrative review.","authors":"Michael Robinson, Sophie Mokrzecki, Andrew J Mallett","doi":"10.1038/s41514-023-00132-2","DOIUrl":"10.1038/s41514-023-00132-2","url":null,"abstract":"Polypharmacy, commonly defined as ≥5 medications, is a rising public health concern due to its many risks of harm. One commonly recommended strategy to address polypharmacy is medication reviews, with subsequent deprescription of inappropriate medications. In this review, we explore the intersection of older age, polypharmacy, and deprescribing in a contemporary context by appraising the published literature (2012-2022) to identify articles that included new primary data on deprescribing medications in patients aged ≥65 years currently taking ≥5 medications. We found 31 articles were found which describe the current perceptions of clinicians towards deprescribing, the identified barriers, key enabling factors, and future directions in approaching deprescribing. Currently, clinicians believe that deprescribing is a complex process, and despite the majority of clinicians reporting feeling comfortable in deprescribing, fewer engage with this process regularly. Common barriers cited include a lack of knowledge and training around the deprescribing process, a lack of time, a breakdown in communication, perceived 'abandonment of care', fear of adverse consequences, and resistance from patients and/or their carers. Common enabling factors of deprescribing include recognition of key opportunities to instigate this process, regular medication reviews, improving lines of communication, education of both patients and clinicians and a multidisciplinary approach towards patient care. Addressing polypharmacy requires a nuanced approach in a generally complex group of patients. Key strategies to reducing the risks of polypharmacy include education of patients and clinicians, in addition to improving communication between healthcare providers in a multidisciplinary approach.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"6"},"PeriodicalIF":4.1,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. 作者更正：原发性开角型青光眼和正常张力型青光眼患者房水中谷胱甘肽水平降低。

npj aging Pub Date : 2024-01-20 DOI: 10.1038/s41514-024-00137-5

Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

引用次数: 0

Cholesterol biosynthetic pathway induces cellular senescence through ERRα. 胆固醇生物合成途径通过ERRα诱导细胞衰老

npj aging Pub Date : 2024-01-12 DOI: 10.1038/s41514-023-00128-y

Dorian V Ziegler, Joanna Czarnecka-Herok, Mathieu Vernier, Charlotte Scholtes, Clara Camprubi, Anda Huna, Amélie Massemin, Audrey Griveau, Christelle Machon, Jérôme Guitton, Jennifer Rieusset, Arnaud M Vigneron, Vincent Giguère, Nadine Martin, David Bernard

{"title":"Cholesterol biosynthetic pathway induces cellular senescence through ERRα.","authors":"Dorian V Ziegler, Joanna Czarnecka-Herok, Mathieu Vernier, Charlotte Scholtes, Clara Camprubi, Anda Huna, Amélie Massemin, Audrey Griveau, Christelle Machon, Jérôme Guitton, Jennifer Rieusset, Arnaud M Vigneron, Vincent Giguère, Nadine Martin, David Bernard","doi":"10.1038/s41514-023-00128-y","DOIUrl":"10.1038/s41514-023-00128-y","url":null,"abstract":"Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated secretory phenotype. Accumulation of senescent cells during age-related diseases participates in these pathologies and regulates healthy lifespan. Recent evidences point out a global dysregulated intracellular metabolism associated to senescence phenotype. Nonetheless, the functional contribution of metabolic homeostasis in regulating senescence is barely understood. In this work, we describe how the mevalonate pathway, an anabolic pathway leading to the endogenous biosynthesis of poly-isoprenoids, such as cholesterol, acts as a positive regulator of cellular senescence in normal human cells. Mechanistically, this mevalonate pathway-induced senescence is partly mediated by the downstream cholesterol biosynthetic pathway. This pathway promotes the transcriptional activity of ERRα that could lead to dysfunctional mitochondria, ROS production, DNA damage and a p53-dependent senescence. Supporting the relevance of these observations, increase of senescence in liver due to a high-fat diet regimen is abrogated in ERRα knockout mouse. Overall, this work unravels the role of cholesterol biosynthesis or level in the induction of an ERRα-dependent mitochondrial program leading to cellular senescence and related pathological alterations.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139433243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning prediction of hepatic steatosis using body composition parameters: A UK Biobank Study. 使用身体成分参数对肝脏脂肪变性进行机器学习预测：英国生物库研究

npj aging Pub Date : 2024-01-09 DOI: 10.1038/s41514-023-00127-z

Delbert Almerick T Boncan, Yan Yu, Miaoru Zhang, Jie Lian, Varut Vardhanabhuti

{"title":"Machine learning prediction of hepatic steatosis using body composition parameters: A UK Biobank Study.","authors":"Delbert Almerick T Boncan, Yan Yu, Miaoru Zhang, Jie Lian, Varut Vardhanabhuti","doi":"10.1038/s41514-023-00127-z","DOIUrl":"10.1038/s41514-023-00127-z","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease worldwide, yet detection has remained largely based on surrogate serum biomarkers, elastography or biopsy. In this study, we used a total of 2959 participants from the UK biobank cohort and established the association of dual-energy X-ray absorptiometry (DXA)-derived body composition parameters and leveraged machine learning models to predict NAFLD. Hepatic steatosis reference was based on MRI-PDFF which has been extensively validated previously. We found several significant associations with traditional measurements such as abdominal obesity, as defined by waist-to-hip ratio (OR = 2.50 (male), 3.35 (female)), android-gynoid ratio (OR = 3.35 (male), 6.39 (female)) and waist circumference (OR = 1.79 (male), 3.80 (female)) with hepatic steatosis. Similarly, A Body Shape Index (Quantile 4 OR = 1.89 (male), 5.81 (female)), and for fat mass index, both overweight (OR = 6.93 (male), 2.83 (female)) and obese (OR = 14.12 (male), 5.32 (female)) categories were likewise significantly associated with hepatic steatosis. DXA parameters were shown to be highly associated such as visceral adipose tissue mass (OR = 8.37 (male), 19.03 (female)), trunk fat mass (OR = 8.64 (male), 25.69 (female)) and android fat mass (OR = 7.93 (male), 21.77 (female)) with NAFLD. We trained machine learning classifiers with logistic regression and two histogram-based gradient boosting ensembles for the prediction of hepatic steatosis using traditional body composition indices and DXA parameters which achieved reasonable performance (AUC = 0.83-0.87). Based on SHapley Additive exPlanations (SHAP) analysis, DXA parameters that had the largest contribution to the classifiers were the features predicted with significant association with NAFLD. Overall, this study underscores the potential utility of DXA as a practical and potentially opportunistic method for the screening of hepatic steatosis.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ensemble learning model for continuous cognition assessment based on resting-state EEG. 基于静息态脑电图的连续认知评估集合学习模型。

IF 4.1

npj aging Pub Date : 2024-01-02 DOI: 10.1038/s41514-023-00129-x

Jingnan Sun, Yike Sun, Anruo Shen, Yunxia Li, Xiaorong Gao, Bai Lu

{"title":"An ensemble learning model for continuous cognition assessment based on resting-state EEG.","authors":"Jingnan Sun, Yike Sun, Anruo Shen, Yunxia Li, Xiaorong Gao, Bai Lu","doi":"10.1038/s41514-023-00129-x","DOIUrl":"10.1038/s41514-023-00129-x","url":null,"abstract":"One critical manifestation of neurological deterioration is the sign of cognitive decline. Causes of cognitive decline include but are not limited to: aging, cerebrovascular disease, Alzheimer's disease, and trauma. Currently, the primary tool used to examine cognitive decline is scale. However, scale examination has drawbacks such as its clinician subjectivity and inconsistent results. This study attempted to use resting-state EEG to construct a cognitive assessment model that is capable of providing a more scientific and robust evaluation on cognition levels. In this study, 75 healthy subjects, 99 patients with Mild Cognitive Impairment (MCI), and 78 patients with dementia were involved. Their resting-state EEG signals were collected twice, and the recording devices varied. By matching these EEG and traditional scale results, the proposed cognition assessment model was trained based on Adaptive Boosting (AdaBoost) and Support Vector Machines (SVM) methods, mapping subjects' cognitive levels to a 0-100 test score with a mean error of 4.82 (<5%). This study is the first to establish a continuous evaluation model of cognitive decline on a large sample dataset. Its cross-device usability also suggests universality and robustness of this EEG model, offering a more reliable and affordable way to assess cognitive decline for clinical diagnosis and treatment as well. Furthermore, the interpretability of features involved may further contribute to the early diagnosis and superior treatment evaluation of Alzheimer's disease.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"1"},"PeriodicalIF":4.1,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases. 孟德尔随机化研究支持空气污染通过多种老年相关疾病对长寿产生因果效应。

npj aging Pub Date : 2023-12-19 DOI: 10.1038/s41514-023-00126-0

Shizheng Qiu, Yang Hu, Guiyou Liu

{"title":"Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases.","authors":"Shizheng Qiu, Yang Hu, Guiyou Liu","doi":"10.1038/s41514-023-00126-0","DOIUrl":"10.1038/s41514-023-00126-0","url":null,"abstract":"Growing evidence suggests that exposure to fine particulate matter (PM2.5) may reduce life expectancy; however, the causal pathways of PM2.5 exposure affecting life expectancy remain unknown. Here, we assess the causal effects of genetically predicted PM2.5 concentration on common chronic diseases and longevity using a Mendelian randomization (MR) statistical framework based on large-scale genome-wide association studies (GWAS) (>400,000 participants). After adjusting for other types of air pollution and smoking, we find significant causal relationships between PM2.5 concentration and angina pectoris, hypercholesterolaemia and hypothyroidism, but no causal relationship with longevity. Mediation analysis shows that although the association between PM2.5 concentration and longevity is not significant, PM2.5 exposure indirectly affects longevity via diastolic blood pressure (DBP), hypertension, angina pectoris, hypercholesterolaemia and Alzheimer's disease, with a mediated proportion of 31.5, 70.9, 2.5, 100, and 24.7%, respectively. Our findings indicate that public health policies to control air pollution may help improve life expectancy.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"9 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0