npj aging最新文献_第9页

Multiscale and multidisciplinary analysis of aging processes in bone. 骨骼老化过程的多尺度和多学科分析。

npj aging Pub Date : 2024-06-15 DOI: 10.1038/s41514-024-00156-2

Linda Ravazzano, Graziana Colaianni, Anna Tarakanova, Yu-Bai Xiao, Maria Grano, Flavia Libonati

{"title":"Multiscale and multidisciplinary analysis of aging processes in bone.","authors":"Linda Ravazzano, Graziana Colaianni, Anna Tarakanova, Yu-Bai Xiao, Maria Grano, Flavia Libonati","doi":"10.1038/s41514-024-00156-2","DOIUrl":"10.1038/s41514-024-00156-2","url":null,"abstract":"The world population is increasingly aging, deeply affecting our society by challenging our healthcare systems and presenting an economic burden, thus turning the spotlight on aging-related diseases: exempli gratia, osteoporosis, a silent disease until you suddenly break a bone. The increase in bone fracture risk with age is generally associated with a loss of bone mass and an alteration in the skeletal architecture. However, such changes cannot fully explain increased fragility with age. To successfully tackle age-related bone diseases, it is paramount to comprehensively understand the fundamental mechanisms responsible for tissue degeneration. Aging mechanisms persist at multiple length scales within the complex hierarchical bone structure, raising the need for a multiscale and multidisciplinary approach to resolve them. This paper aims to provide an overarching analysis of aging processes in bone and to review the most prominent outcomes of bone aging. A systematic description of different length scales, highlighting the corresponding techniques adopted at each scale and motivating the need for combining diverse techniques, is provided to get a comprehensive description of the multi-physics phenomena involved.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study. 调查健康大脑老化的营养生物标志物：多模态大脑成像研究。

npj aging Pub Date : 2024-05-21 DOI: 10.1038/s41514-024-00150-8

Christopher E Zwilling, Jisheng Wu, Aron K Barbey

{"title":"Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study.","authors":"Christopher E Zwilling, Jisheng Wu, Aron K Barbey","doi":"10.1038/s41514-024-00150-8","DOIUrl":"10.1038/s41514-024-00150-8","url":null,"abstract":"The emerging field of Nutritional Cognitive Neuroscience aims to uncover specific foods and nutrients that promote healthy brain aging. Central to this effort is the discovery of nutrient profiles that can be targeted in nutritional interventions designed to promote brain health with respect to multimodal neuroimaging measures of brain structure, function, and metabolism. The present study therefore conducted one of the largest and most comprehensive nutrient biomarker studies examining multimodal neuroimaging measures of brain health within a sample of 100 older adults. To assess brain health, a comprehensive battery of well-established cognitive and brain imaging measures was administered, along with 13 blood-based biomarkers of diet and nutrition. The findings of this study revealed distinct patterns of aging, categorized into two phenotypes of brain health based on hierarchical clustering. One phenotype demonstrated an accelerated rate of aging, while the other exhibited slower-than-expected aging. A t-test analysis of dietary biomarkers that distinguished these phenotypes revealed a nutrient profile with higher concentrations of specific fatty acids, antioxidants, and vitamins. Study participants with this nutrient profile demonstrated better cognitive scores and delayed brain aging, as determined by a t-test of the means. Notably, participant characteristics such as demographics, fitness levels, and anthropometrics did not account for the observed differences in brain aging. Therefore, the nutrient pattern identified by the present study motivates the design of neuroscience-guided dietary interventions to promote healthy brain aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances and future trends of hormesis in disease. 疾病中激素作用的当前进展和未来趋势。

npj aging Pub Date : 2024-05-15 DOI: 10.1038/s41514-024-00155-3

Yantong Wan, Jinxi Liu, Yiyin Mai, Yinghao Hong, Zixuan Jia, Guijie Tian, Yunzhuo Liu, Huaping Liang, Jinghua Liu

{"title":"Current advances and future trends of hormesis in disease.","authors":"Yantong Wan, Jinxi Liu, Yiyin Mai, Yinghao Hong, Zixuan Jia, Guijie Tian, Yunzhuo Liu, Huaping Liang, Jinghua Liu","doi":"10.1038/s41514-024-00155-3","DOIUrl":"10.1038/s41514-024-00155-3","url":null,"abstract":"Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces a stimulatory effect, while higher doses may inhibit it. This phenomenon is widely observed across various organisms and stressors, significantly advancing our understanding and inspiring further exploration of the beneficial effects of toxins at doses both below and beyond traditional thresholds. This has profound implications for promoting biological regulation at the cellular level and enhancing adaptability throughout the biosphere. Therefore, conducting bibliometric analysis in this field is crucial for accurately analyzing and summarizing its current research status. The results of the bibliometric analysis reveal a steady increase in the number of publications in this field over the years. The United States emerges as the leading country in both publication and citation numbers, with the journal Dose-Response publishing the highest number of papers in this area. Calabrese E.J. is a prominent person with significant contributions and influence among authors. Through keyword co-occurrence and trend analysis, current hotspots in this field are identified, primarily focusing on the relationship between hormesis, oxidative stress, and aging. Analysis of highly cited references predicts that future research trends may center around the relationship between hormesis and stress at different doses, as well as exploring the mechanisms and applications of hormesis. In conclusion, this review aims to visually represent hormesis-related research through bibliometric methods, uncovering emerging patterns and areas of focus within the field. It provides a summary of the current research status and forecasts trends in hormesis-related research.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Healthcare on the brink: navigating the challenges of an aging society in the United States. 作者更正：濒临崩溃的医疗保健：迎接美国老龄化社会的挑战》。

npj aging Pub Date : 2024-05-10 DOI: 10.1038/s41514-024-00153-5

Charles H Jones, Mikael Dolsten

引用次数: 0

Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline. 正常老年人的脑萎缩将牙齿脱落和饮食变化与未来认知能力下降联系起来。

npj aging Pub Date : 2024-03-22 DOI: 10.1038/s41514-024-00146-4

Hiroyuki Nakamura, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Yutaka Kobayashi, Mikana Isa, Kentaro Ide, Toshihiro Kawano, Shuichi Kawashiri, Kazuhiro Uchida, Yasuko Tatewaki, Yasuyuki Taki, Tomoyuki Ohara, Toshiharu Ninomiya, Kenjiro Ono

{"title":"Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline.","authors":"Hiroyuki Nakamura, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Yutaka Kobayashi, Mikana Isa, Kentaro Ide, Toshihiro Kawano, Shuichi Kawashiri, Kazuhiro Uchida, Yasuko Tatewaki, Yasuyuki Taki, Tomoyuki Ohara, Toshiharu Ninomiya, Kenjiro Ono","doi":"10.1038/s41514-024-00146-4","DOIUrl":"10.1038/s41514-024-00146-4","url":null,"abstract":"Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclear. We conducted a population-based longitudinal cohort study in Nakajima, Nanao City, Japan. Between 2016 and 2018, 2454 residents aged ≥60 participated, covering 92.9% of the local age demographics. This study used comprehensive approach by combining detailed dental examinations, dietary assessments, magnetic resonance imaging (MRI) analysis, and cognitive evaluations. Tooth loss, even in cognitively normal individuals, is associated with parahippocampal gyrus atrophy and increased WMH volume, both of which are characteristics of dementia. Tooth loss was associated with altered dietary patterns, notably a reduction in plant-based food intake and an increase in fatty, processed food intake. This study highlights a possible preventative pathway where oral health may play a significant role in preventing the early neuropathological shifts associated with dementia.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression. 阿尔茨海默病患者大脑中先天性免疫反应向适应性免疫反应的转换与牛磺酸病的进展有关。

npj aging Pub Date : 2024-03-18 DOI: 10.1038/s41514-024-00145-5

Marcos R Costa

引用次数: 0

Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans. FOXO3 长寿基因型对冲绳人细胞衰老机制的新保护作用。

IF 4.1

npj aging Pub Date : 2024-03-08 DOI: 10.1038/s41514-024-00142-8

Trevor H Torigoe, D Craig Willcox, Michio Shimabukuro, Moritake Higa, Mariana Gerschenson, Anastasia Andrukhiv, Makoto Suzuki, Brian J Morris, Randi Chen, Greg S Gojanovich, Richard C Allsopp, Bradley J Willcox

{"title":"Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans.","authors":"Trevor H Torigoe, D Craig Willcox, Michio Shimabukuro, Moritake Higa, Mariana Gerschenson, Anastasia Andrukhiv, Makoto Suzuki, Brian J Morris, Randi Chen, Greg S Gojanovich, Richard C Allsopp, Bradley J Willcox","doi":"10.1038/s41514-024-00142-8","DOIUrl":"10.1038/s41514-024-00142-8","url":null,"abstract":"The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism is not fully understood. We now report on the relationship of the FOXO3 longevity variant rs2802292 with telomere length, telomerase activity, FOXO3 expression, and inflammatory cytokine levels in men and women. In agreement with earlier work, the FOXO3 longevity variant conferred protection against telomere shortening of peripheral blood mononuclear cells from adults aged 55 years and older. This was accompanied by higher levels of telomerase activity in mononuclear cells for carriers of the longevity-associated FOXO3 G-allele of SNP rs2802292 (P = 0.015). FOXO3 mRNA expression increased slightly with age in both young (P = 0.02) and old (P = 0.08) G-allele carriers. Older female G-allele carriers displayed a modest decline in levels of pro-inflammatory cytokine IL-6 with age (P = 0.07). In contrast, older male G-allele carriers displayed an age-dependent increase in levels of anti-inflammatory cytokine IL-10 with age (P = 0.04). Thus, FOXO3 may act through several different pro-longevity mechanisms, which may differ by age and sex.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"18"},"PeriodicalIF":4.1,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ageing and frailty on circulating monocyte and dendritic cell subsets. 衰老和虚弱对循环单核细胞和树突状细胞亚群的影响。

npj aging Pub Date : 2024-03-04 DOI: 10.1038/s41514-024-00144-6

Rosanne D Reitsema, Ashok K Kumawat, Bernd-Cornèl Hesselink, Debbie van Baarle, Yannick van Sleen

{"title":"Effects of ageing and frailty on circulating monocyte and dendritic cell subsets.","authors":"Rosanne D Reitsema, Ashok K Kumawat, Bernd-Cornèl Hesselink, Debbie van Baarle, Yannick van Sleen","doi":"10.1038/s41514-024-00144-6","DOIUrl":"10.1038/s41514-024-00144-6","url":null,"abstract":"Ageing is associated with dysregulated immune responses, resulting in impaired resilience against infections and low-grade inflammation known as inflammageing. Frailty is a measurable condition in older adults characterized by decreased health and physical impairment. Dendritic cells (DCs) and monocytes play a crucial role in initiating and steering immune responses. To assess whether their frequencies and phenotypes in the blood are affected by ageing or frailty, we performed a flow cytometry study on monocyte and DC subsets in an immune ageing cohort. We included (n = 15 in each group) healthy young controls (HYC, median age 29 years), healthy older controls (HOC, 73 years) and Frail older controls (76 years). Monocyte subsets (classical, intermediate, non-classical) were identified by CD14 and CD16 expression, and DC subsets (conventional (c)DC1, cDC2, plasmacytoid (p)DC) by CD11c, CD1c, CD141 and CD303 expression. All subsets were checked for TLR2, TLR4, HLA-DR, CD86, PDL1, CCR7 and CD40 expression. We observed a lower proportion of pDCs in HOC compared to HYC. Additionally, we found higher expression of activation markers on classical and intermediate monocytes and on cDC2 in HOC compared to HYC. Frail participants had a higher expression of CD40 on classical and non-classical monocytes compared to the HOC group. We document a substantial effect of ageing on monocytes and DCs. Reduced pDCs in older people may underlie their impaired ability to counter viral infections, whereas enhanced expression of activation markers could indicate a state of inflammageing. Future studies could elucidate the functional consequences of CD40 upregulation with frailty.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Your move: A precision medicine framework for physical activity in aging. 你的运动老龄体育活动的精准医学框架。

npj aging Pub Date : 2024-02-27 DOI: 10.1038/s41514-024-00141-9

Adrián Noriega de la Colina, Timothy P Morris, Arthur F Kramer, Navin Kaushal, Maiya R Geddes

引用次数: 0

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. 年龄-疾病相互作用加速弹性蛋白降解：老年相关疾病的共同特征。

IF 4.1

npj aging Pub Date : 2024-02-27 DOI: 10.1038/s41514-024-00143-7

Naomi Shek, Anna-Maria Choy, Chim C Lang, Bruce E Miller, Ruth Tal-Singer, Charlotte E Bolton, Neil C Thomson, James D Chalmers, Matt J Bown, David E Newby, Faisel Khan, Jeffrey T J Huang

引用次数: 0