npj aging最新文献_第8页

Aging insights from heterochronic parabiosis models. 从异时同种异体移植模型中了解衰老。

IF 4.1

npj aging Pub Date : 2024-08-17 DOI: 10.1038/s41514-024-00166-0

Francisco Alejandro Lagunas-Rangel

引用次数: 0

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation. Precious2GPT：多组学预训练变换器与条件扩散相结合，用于人工多组学多物种多组织样本生成。

IF 4.1

npj aging Pub Date : 2024-08-08 DOI: 10.1038/s41514-024-00163-3

Denis Sidorenko, Stefan Pushkov, Akhmed Sakip, Geoffrey Ho Duen Leung, Sarah Wing Yan Lok, Anatoly Urban, Diana Zagirova, Alexander Veviorskiy, Nina Tihonova, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov

{"title":"Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation.","authors":"Denis Sidorenko, Stefan Pushkov, Akhmed Sakip, Geoffrey Ho Duen Leung, Sarah Wing Yan Lok, Anatoly Urban, Diana Zagirova, Alexander Veviorskiy, Nina Tihonova, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov","doi":"10.1038/s41514-024-00163-3","DOIUrl":"10.1038/s41514-024-00163-3","url":null,"abstract":"Synthetic data generation in omics mimics real-world biological data, providing alternatives for training and evaluation of genomic analysis tools, controlling differential expression, and exploring data architecture. We previously developed Precious1GPT, a multimodal transformer trained on transcriptomic and methylation data, along with metadata, for predicting biological age and identifying dual-purpose therapeutic targets potentially implicated in aging and age-associated diseases. In this study, we introduce Precious2GPT, a multimodal architecture that integrates Conditional Diffusion (CDiffusion) and decoder-only Multi-omics Pretrained Transformer (MoPT) models trained on gene expression and DNA methylation data. Precious2GPT excels in synthetic data generation, outperforming Conditional Generative Adversarial Networks (CGANs), CDiffusion, and MoPT. We demonstrate that Precious2GPT is capable of generating representative synthetic data that captures tissue- and age-specific information from real transcriptomics and methylomics data. Notably, Precious2GPT surpasses other models in age prediction accuracy using the generated data, and it can generate data beyond 120 years of age. Furthermore, we showcase the potential of using this model in identifying gene signatures and potential therapeutic targets in a colorectal cancer case study.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"37"},"PeriodicalIF":4.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration. 阿尔茨海默病和老年性黄斑变性具有共同的整体环境病因。

IF 4.1

npj aging Pub Date : 2024-08-05 DOI: 10.1038/s41514-024-00162-4

Siting Ye, Shuo Ma, Shunming Liu, Yu Huang, Dantong Li, Min Li, Ting Su, Jing Luo, Chi Zhang, Danli Shi, Lianting Hu, Lei Zhang, Honghua Yu, Mingguang He, Xianwen Shang, Xueli Zhang

{"title":"Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration.","authors":"Siting Ye, Shuo Ma, Shunming Liu, Yu Huang, Dantong Li, Min Li, Ting Su, Jing Luo, Chi Zhang, Danli Shi, Lianting Hu, Lei Zhang, Honghua Yu, Mingguang He, Xianwen Shang, Xueli Zhang","doi":"10.1038/s41514-024-00162-4","DOIUrl":"10.1038/s41514-024-00162-4","url":null,"abstract":"The comorbidity of Alzheimer's disease (AD) and age-related macular degeneration (AMD) has been established in clinical and genetic studies. There is growing interest in determining the shared environmental factors associated with both conditions. Recent advancements in record linkage techniques enable us to identify the contributing factors to AD and AMD from a wide range of variables. As such, we first constructed a knowledge graph based on the literature, which included all statistically significant risk factors for AD and AMD. An environment-wide association study (EWAS) was conducted to assess the contribution of various environmental factors to the comorbidity of AD and AMD based on the UK biobank. Based on the conditional Q-Q plots and Bayesian algorithm, several shared environmental factors were identified, which could be categorized into the domains of health condition, biological sample parameters, body index, and attendance availability. Finally, we generated a shared etiology landscape for AD and AMD by combining existing knowledge with our novel findings.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"36"},"PeriodicalIF":4.1,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cellular senescence in ovarian aging. 细胞衰老在卵巢衰老中的作用。

IF 4.1

npj aging Pub Date : 2024-07-20 DOI: 10.1038/s41514-024-00157-1

Jéssica D Hense, José V V Isola, Driele N Garcia, Larissa S Magalhães, Michal M Masternak, Michael B Stout, Augusto Schneider

引用次数: 0

Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention. 通过 PEPITEM 干预，使老龄小鼠的白细胞贩运恢复活力。

IF 4.1

npj aging Pub Date : 2024-07-18 DOI: 10.1038/s41514-024-00160-6

Sophie J Hopkin, Poppy Nathan, Laleh Pezhman, Jenefa Begum, Julia E Manning, Lauren M Quinn, G Ed Rainger, Helen M McGettrick, Asif J Iqbal, Myriam Chimen

引用次数: 0

The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis. 髌下脂肪垫在炎症、膝关节健康和骨关节炎中的作用。

IF 4.1

npj aging Pub Date : 2024-07-15 DOI: 10.1038/s41514-024-00159-z

Magnolia G Wang, Patrick Seale, David Furman

引用次数: 0

Strategies for modeling aging and age-related diseases. 衰老和老年相关疾病建模策略。

IF 4.1

npj aging Pub Date : 2024-07-10 DOI: 10.1038/s41514-024-00161-5

D Jothi, Linda Anna Michelle Kulka

引用次数: 0

Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations. TgF344-AD 阿尔茨海默病大鼠模型缺省模式样网络中的节点度中心性作为早期网络改变的衡量标准。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00151-7

Saba Amiri, Monica van den Berg, Mohammad-Reza Nazem-Zadeh, Marleen Verhoye, Mahmood Amiri, Georgios A Keliris

{"title":"Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations.","authors":"Saba Amiri, Monica van den Berg, Mohammad-Reza Nazem-Zadeh, Marleen Verhoye, Mahmood Amiri, Georgios A Keliris","doi":"10.1038/s41514-024-00151-7","DOIUrl":"10.1038/s41514-024-00151-7","url":null,"abstract":"This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of Alzheimer's disease (AD) with application in the development of early diagnostic biomarkers of AD in translational studies. Thirteen male TgF344-AD (TG) rats, and eleven male wild-types (WT) littermates underwent longitudinal resting-state fMRI at the age of 4 and 6 months (pre and early-plaque stages of AD). Alterations in connectivity within DMLN were characterized by calculating the nodal degree (ND), a graph theoretical measure of centrality. The ND values of the left CA2 subregion of the hippocampus was found to be significantly lower in the 4-month-old TG cohort compared to the age-matched WT littermates. Moreover, a lower ND value (hypo-connectivity) was observed in the right prelimbic cortex (prL) and basal forebrain in the 6-month-old TG cohort, compared to the same age WT cohort. Indeed, the ND pattern in the DMLN in both TG and WT cohorts showed significant differences across the two time points that represent pre-plaque and early plaque stages of disease progression. Our findings indicate that lower nodal degree (hypo-connectivity) in the left CA2 in the pre-plaque stage of AD and hypo-connectivity between the basal forebrain and the DMLN regions in the early-plaque stage demonstrated differences in comparison to healthy controls. These results suggest that a graph-theoretical measure such as the nodal degree, can characterize brain networks and improve our insights into the mechanisms underlying Alzheimer's disease.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"29"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns. 对猕猴整个生命周期的转录组分析揭示了与年龄相关的免疫模式。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00158-0

Hyeon-Mu Cho, Se-Hee Choe, Ja-Rang Lee, Hye-Ri Park, Min-Gyeong Ko, Yun-Jung Lee, Hwal-Yong Lee, Sung Hyun Park, Sang-Je Park, Young-Hyun Kim, Jae-Won Huh

{"title":"Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns.","authors":"Hyeon-Mu Cho, Se-Hee Choe, Ja-Rang Lee, Hye-Ri Park, Min-Gyeong Ko, Yun-Jung Lee, Hwal-Yong Lee, Sung Hyun Park, Sang-Je Park, Young-Hyun Kim, Jae-Won Huh","doi":"10.1038/s41514-024-00158-0","DOIUrl":"10.1038/s41514-024-00158-0","url":null,"abstract":"Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristics of eight male healthy cynomolgus macaques, and the annual sampling was designed with two individuals in four age groups. As a laboratory animal, the macaques were meticulously shielded from all environmental factors except aging. The results showed recent findings of certain immune response and the age-associated network of primate immunity. Three important aging patterns were identified and each gene clusters represented a different immune response. The increased expression pattern was predominantly associated with innate immune cells, such as Neutrophils and NK cells, causing chronic inflammation with aging whereas the other two decreased patterns were associated with adaptive immunity, especially \"B cell activation\" affecting antibody diversity of aging. Furthermore, the hub gene network of the patterns reflected transcriptomic age and correlated with human illness status, aiding in future human disease prediction. Our macaque transcriptome profiling results offer systematic insights into the age-related immunological features of primates.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"30"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice. 动脉瘤Fibulin-4突变小鼠血管平滑肌细胞衰老加剧。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00154-4

Sanne J M Stefens, Nicole van Vliet, Arne IJpma, Joyce Burger, Yunlei Li, Paula M van Heijningen, Jan H N Lindeman, Danielle Majoor-Krakauer, Hence J M Verhagen, Roland Kanaar, Jeroen Essers, Ingrid van der Pluijm

{"title":"Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.","authors":"Sanne J M Stefens, Nicole van Vliet, Arne IJpma, Joyce Burger, Yunlei Li, Paula M van Heijningen, Jan H N Lindeman, Danielle Majoor-Krakauer, Hence J M Verhagen, Roland Kanaar, Jeroen Essers, Ingrid van der Pluijm","doi":"10.1038/s41514-024-00154-4","DOIUrl":"10.1038/s41514-024-00154-4","url":null,"abstract":"Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used the aneurysmal Fibulin-4R/R mouse model to further unravel the underlying mechanisms of aneurysm formation. RNA sequencing of 3-month-old Fibulin-4R/R aortas revealed significant upregulation of senescence-associated secretory phenotype (SASP) factors and key senescence factors, indicating the involvement of senescence. Analysis of aorta histology and of vascular smooth muscle cells (VSMCs) in vitro confirmed the senescent phenotype of Fibulin-4R/R VSMCs by revealing increased SA-β-gal, p21, and p16 staining, increased IL-6 secretion, increased presence of DNA damage foci and increased nuclei size. Additionally, we found that p21 luminescence was increased in the dilated aorta of Fibulin-4R/R|p21-luciferase mice. Our studies identify a cellular aging cascade in Fibulin-4 aneurysmal disease, by revealing that Fibulin-4R/R aortic VSMCs have a pronounced SASP and a senescent phenotype that may underlie aortic wall degeneration. Additionally, we demonstrated the therapeutic effect of JAK/STAT and TGF-β pathway inhibition, as well as senolytic treatment on Fibulin-4R/R VSMCs in vitro. These findings can contribute to improved therapeutic options for aneurysmal disease aimed at reducing senescent cells.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"31"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0