npj aging最新文献_第7页

Drug safety in healthy aging. 健康老龄化中的药物安全。

IF 4.1

npj aging Pub Date : 2025-04-12 DOI: 10.1038/s41514-025-00220-5

Nikola Panajotovikj, Adrià Fernández-Torras, Jordi Mestres

引用次数: 0

1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty. 基于1h - nmr的代谢组学鉴定出甜菜碱代谢紊乱是虚弱前的明显血清特征。

IF 4.1

npj aging Pub Date : 2025-04-12 DOI: 10.1038/s41514-025-00218-z

Carmen Marino, Alberto Imarisio, Clara Gasparri, Enza Napolitano, Anna Di Maio, Micol Avenali, Gabriele Buongarzone, Caterina Galandra, Marta Picascia, Manuela Grimaldi, Francesco Errico, Mariangela Rondanelli, Anna Maria D'Ursi, Enza Maria Valente, Alessandro Usiello

引用次数: 0

Vegetarian diet and healthy aging among Chinese older adults: a prospective study. 素食与中国老年人的健康老龄化：一项前瞻性研究。

IF 4.1

npj aging Pub Date : 2025-04-01 DOI: 10.1038/s41514-025-00213-4

Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao

{"title":"Vegetarian diet and healthy aging among Chinese older adults: a prospective study.","authors":"Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao","doi":"10.1038/s41514-025-00213-4","DOIUrl":"10.1038/s41514-025-00213-4","url":null,"abstract":"Vegetarian diets are increasingly popular worldwide, but their impact on healthy aging in older adults remains unclear. This study examined the association between vegetarian diets and healthy aging among 2,888 healthy older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey. Dietary patterns (vegan, ovo-vegetarian, pesco-vegetarian, omnivorous) were derived from a simplified non-quantitative food frequency questionnaire. Over a median follow-up of 6 years, after accounting for sociodemographic and lifestyle factors, vegetarians had lower odds of achieving healthy aging compared to omnivores (adjusted OR = 0.65, 95% CI: 0.47-0.89), with consistent results across sensitivity analyses and individual health components. Additionally, the health effects of vegetarian diets may vary depending on diet quality, with vegetarians of higher diet quality not significantly differing in terms of overall healthy aging and individual outcomes when compared to omnivores. Accordingly, this finding highlights modest inclusion of animal-based foods may improve the overall health status of healthy older adults.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"25"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian vascular aging: a hidden driver of mid-age female fertility decline. 卵巢血管老化：中年女性生育能力下降的隐性驱动因素。

IF 4.1

npj aging Pub Date : 2025-03-30 DOI: 10.1038/s41514-025-00216-1

Ge Wang, Ruobing Yang, Hua Zhang

引用次数: 0

Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila. Pan-PTM分析鉴定了与果蝇异常长寿和骨骼肌功能保存相关的翻译后修饰。

IF 4.1

npj aging Pub Date : 2025-03-30 DOI: 10.1038/s41514-025-00215-2

Suresh Poudel, Chia-Lung Chuang, Him K Shrestha, Fabio Demontis

{"title":"Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila.","authors":"Suresh Poudel, Chia-Lung Chuang, Him K Shrestha, Fabio Demontis","doi":"10.1038/s41514-025-00215-2","DOIUrl":"10.1038/s41514-025-00215-2","url":null,"abstract":"Skeletal muscle weakness is a major component of age-associated frailty, but the underlying mechanisms are not completely understood. Drosophila has emerged as a useful model for studying skeletal muscle aging. In this organism, previous lab-based selection established strains with increased longevity and reduced age-associated muscle functional decline compared to a parental strain. Here, we have applied a computational pipeline (JUMPptm) for retrieving information on 8 post-translational modifications (PTMs) from the skeletal muscle proteomes of 2 long-lived strains and the corresponding parental strain in young and old age. This pan-PTM analysis identified 2470 modified sites (acetylation, carboxylation, deamidation, dihydroxylation, mono-methylation, oxidation, phosphorylation, and ubiquitination) in several classes of proteins, including evolutionarily conserved muscle contractile proteins and metabolic enzymes. PTM consensus sequences further highlight the amino acids that are enriched adjacent to the modified site, thus providing insight into the flanking residues that influence distinct PTMs. Altogether, these analyses identify PTMs associated with muscle functional decline during aging and that may underlie the longevity and negligible functional senescence of lab-evolved Drosophila strains.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"23"},"PeriodicalIF":4.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil). 用机器学习预测50岁及以上巴西人的全因死亡率：巴西老龄化纵向研究（ELSI-Brazil）的结果。

IF 4.1

npj aging Pub Date : 2025-03-28 DOI: 10.1038/s41514-025-00210-7

Felipe Mendes Delpino, Alexandre Dias Porto Chiavegatto Filho, Juliana Lustosa Torres, Fabíola Bof de Andrade, Maria Fernanda Lima-Costa, Bruno Pereira Nunes

{"title":"Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil).","authors":"Felipe Mendes Delpino, Alexandre Dias Porto Chiavegatto Filho, Juliana Lustosa Torres, Fabíola Bof de Andrade, Maria Fernanda Lima-Costa, Bruno Pereira Nunes","doi":"10.1038/s41514-025-00210-7","DOIUrl":"https://doi.org/10.1038/s41514-025-00210-7","url":null,"abstract":"We aimed to develop a machine-learning model to predict all-cause mortality among Brazilians aged 50 and over, incorporating demographic, health, and lifestyle characteristics as predictors. We analyzed data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), waves 1 and 2 (2015-2021), a nationally representative sample from 70 municipalities across Brazil's five regions. Nine algorithms, including Random Forest, Gradient Boosting, XGBOOST, and Logistic Regression, were tested on 9412 participants (54.6% female), with 970 deaths recorded over approximately five years. Using 59 predictor variables, we assessed performance with metrics like AUC, accuracy, precision, and F1-Score. Random Forest excelled with an AUC of 0.92 (95% CI: 0.90-0.94). SHAP analysis highlighted age, sex, BMI, medication use, and physical activity as top predictors. Integrating these models into healthcare systems can improve policy planning and enable targeted interventions, ultimately fostering better health outcomes for aging populations.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"22"},"PeriodicalIF":4.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice. 通过samul -tang诱导的转录组特征鉴定的丁基酞可改善老年小鼠的卵母细胞质量。

IF 4.1

npj aging Pub Date : 2025-03-26 DOI: 10.1038/s41514-025-00214-3

Hyejin Shin, Haeseung Lee, Musun Park, Kyuwon Son, Myunggyo Lee, Ami Lee, Seongwon Cha, Sooseong You

{"title":"Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.","authors":"Hyejin Shin, Haeseung Lee, Musun Park, Kyuwon Son, Myunggyo Lee, Ami Lee, Seongwon Cha, Sooseong You","doi":"10.1038/s41514-025-00214-3","DOIUrl":"10.1038/s41514-025-00214-3","url":null,"abstract":"Samul-tang (SM) is a traditional prescription widely used in clinical practice for the management of gynecological diseases, especially for menstrual regulation and infertility treatment. We previously reported its efficacy in increasing mature oocyte production and improving ovarian reserves, potentially regulated by rat sarcoma virus (Ras) signaling in the ovaries of aged mice. Although the main ingredients of SM are known, the bioactive compounds responsible for protecting ovarian function during aging remain unidentified. This study aimed to identify the active compounds that significantly contribute to the therapeutic potential of SM against age-related decline in ovarian function. The combination of butylphthalide and oleanolic acid improved mature oocyte production similar to that in SM-administered aged mice. Subsequently, we identified butylphthalide as an active compound that mimicked SM's effect on enhancing ovarian reserve. This study introduces a novel strategy for identifying active compounds in multi-component herbal medicines by evaluating compound combinations in an in vivo model, offering promising therapeutic avenues for age-related female infertility through targeted gene expression modulation.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"21"},"PeriodicalIF":4.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing metabolic health with digital twins. 利用数字双胞胎优化代谢健康。

IF 4.1

npj aging Pub Date : 2025-03-24 DOI: 10.1038/s41514-025-00211-6

Chengxun Su, Peter Wang, Nigel Foo, Dean Ho

引用次数: 0

Author Correction: The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy. 作者更正：采用 PCSK9 抑制剂和他汀类药物联合疗法的冠状动脉钙化年发生率低于他汀类药物单药疗法。

IF 4.1

npj aging Pub Date : 2025-03-19 DOI: 10.1038/s41514-025-00208-1

Yuichi Ikegami, Ikuo Inoue, Kaiji Inoue, Yuichi Shinoda, Shinichiro Iida, Seiichi Goto, Takanari Nakano, Akira Shimada, Mitsuhiko Noda

引用次数: 0

Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer's disease. 小胶质细胞中的Atg5调节阿尔茨海默病出生后神经发生的性别特异性作用。