通过samul -tang诱导的转录组特征鉴定的丁基酞可改善老年小鼠的卵母细胞质量。

IF 4.1 Q2 GERIATRICS & GERONTOLOGY
Hyejin Shin, Haeseung Lee, Musun Park, Kyuwon Son, Myunggyo Lee, Ami Lee, Seongwon Cha, Sooseong You
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引用次数: 0

摘要

三母汤是临床上广泛应用于妇科疾病治疗的传统方剂,特别是用于调节月经和治疗不孕症。我们之前报道了它在增加成熟卵母细胞产生和改善卵巢储备方面的功效,这可能是由老年小鼠卵巢中的大鼠肉瘤病毒(Ras)信号调节的。虽然SM的主要成分是已知的,但在衰老过程中保护卵巢功能的生物活性化合物仍未确定。本研究旨在确定SM治疗卵巢功能年龄相关性下降的活性化合物。丁基酞和齐墩果酸联合使用后,成熟卵母细胞的生成与sm给药小鼠相似。随后,我们发现丁苯酞是一种活性化合物,可以模拟SM增强卵巢储备的作用。本研究介绍了一种新的策略,通过在体内模型中评估化合物组合来鉴定多成分草药中的活性化合物,为通过靶向基因表达调节治疗与年龄相关的女性不孕症提供了有希望的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.

Samul-tang (SM) is a traditional prescription widely used in clinical practice for the management of gynecological diseases, especially for menstrual regulation and infertility treatment. We previously reported its efficacy in increasing mature oocyte production and improving ovarian reserves, potentially regulated by rat sarcoma virus (Ras) signaling in the ovaries of aged mice. Although the main ingredients of SM are known, the bioactive compounds responsible for protecting ovarian function during aging remain unidentified. This study aimed to identify the active compounds that significantly contribute to the therapeutic potential of SM against age-related decline in ovarian function. The combination of butylphthalide and oleanolic acid improved mature oocyte production similar to that in SM-administered aged mice. Subsequently, we identified butylphthalide as an active compound that mimicked SM's effect on enhancing ovarian reserve. This study introduces a novel strategy for identifying active compounds in multi-component herbal medicines by evaluating compound combinations in an in vivo model, offering promising therapeutic avenues for age-related female infertility through targeted gene expression modulation.

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CiteScore
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