npj aging最新文献_第3页

Senolytic effects of a modified Gingerenone A. 改性姜酮a的抗衰老作用。

IF 4.1

npj aging Pub Date : 2025-05-30 DOI: 10.1038/s41514-025-00230-3

Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci

{"title":"Senolytic effects of a modified Gingerenone A.","authors":"Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci","doi":"10.1038/s41514-025-00230-3","DOIUrl":"10.1038/s41514-025-00230-3","url":null,"abstract":"Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very few senotherapeutic (senolytics and senomorphics) compounds have been identified. In a recent study, we reported that gingerenone A (GinA) has a senolytic effect via mechanisms including the activation of caspase-3 activity and apoptotic cell death. In this study, we investigated whether GinA has senotherapeutic properties in a mouse model of senescence. Moreover, we modified GinA with eicosapentaenoic acid (EPA) esters (GinA-EPA) or docosahexaenoic acid (DHA) esters (GinA-DHA) to generate modified gingerenone A (modGinA) that could enhance GinA effects. We found that both GinA and modGinA induced biochemical and histological changes consistent with anti-inflammatory, senolytic, and senomorphic effects, leading to improved metabolic and mitochondrial functions.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging. 健康衰老中白质损伤体积与认知的皮质下脑容量差异。

IF 4.1

npj aging Pub Date : 2025-05-28 DOI: 10.1038/s41514-025-00234-z

Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander

{"title":"Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.","authors":"Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander","doi":"10.1038/s41514-025-00234-z","DOIUrl":"10.1038/s41514-025-00234-z","url":null,"abstract":"White matter hyperintensity (WMH) lesions associated with small vessel cerebrovascular disease (CVD) are common structural neuroimaging findings in older adults. Greater global brain WMH burden related to aging has been implicated in dementia but has also been linked to brain atrophy and cognitive dysfunction in old age. We sought to investigate the regionally distributed association of global WMH lesion load with subcortical gray matter (SGM) volumes using a multivariate network analysis method in 178 community-dwelling, healthy older adults (mean age = 69.77 ± 10.22 years). We additionally applied mediation models with WMH-related subcortical volumetric differences as a mediator to evaluate a potential global WMH-related vascular risk pathway leading to cognitive aging. Global WMH burden was associated with a regionally distributed pattern of SGM atrophy involving bilateral putamen and left nucleus accumbens, with relative volume increases in bilateral caudate nucleus. Mediation analyses revealed that increasing age predicted greater WMH-SGM pattern expression, which then predicted slowed processing speed that was, in turn, associated with decrements in other age-sensitive cognitive domains of memory, executive functioning, and fine motor function. These results suggest that the multivariate WMH-SGM pattern and its association with processing speed may provide an important early indicator of age-related decrements in higher-order cognitive processes, reflecting a potential link between CVD and broader cognitive dysfunction across multiple domains in healthy aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study. 二甲双胍可改善老年烧伤患者的不良结局：一项单中心队列研究。

IF 4.1

npj aging Pub Date : 2025-05-26 DOI: 10.1038/s41514-025-00224-1

Dalia Barayan, Fadi Khalaf, Sarah Rehou, Diana Julia Tedesco, Punit Bhattachan, Gregory Pond, Abdikarim Abdullahi, Marc G Jeschke

{"title":"Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study.","authors":"Dalia Barayan, Fadi Khalaf, Sarah Rehou, Diana Julia Tedesco, Punit Bhattachan, Gregory Pond, Abdikarim Abdullahi, Marc G Jeschke","doi":"10.1038/s41514-025-00224-1","DOIUrl":"10.1038/s41514-025-00224-1","url":null,"abstract":"This study assesses the safety and efficacy of metformin administration in older adult burn patients, a rapidly growing demographic with substantially poorer outcomes. This is a single-centre cohort study of older adults (≥60 years) admitted to a provincial burn center over 15 years. Clinical outcomes, laboratory measures, inflammatory markers, and adipose tissue single-nuclei RNA sequencing (SnRNA-seq) were compared among metformin-treated and non-treated controls. A total of 50 metformin-treated and 262 control older burn patients met the eligibility criteria. Despite pre-admission comorbidities, metformin-treated patients showed improved survival, no significant differences in the number of hypoglycemic episodes, a lower incidence of lactic acidosis, and reduced circulating levels of organ damage markers. SnRNA-Seq further revealed that metformin may exert its beneficial effects by local restoration of immune and inflammatory responses. In older burn patients, metformin was linked with improved outcomes and no adverse effects, underscoring its safety and efficacy in this population.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"43"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia. C1QA、C1QB、C1QC和C5AR1失调作为血管性痴呆的候选生物标志物。

IF 4.1

npj aging Pub Date : 2025-05-25 DOI: 10.1038/s41514-025-00228-x

Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi

{"title":"Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia.","authors":"Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi","doi":"10.1038/s41514-025-00228-x","DOIUrl":"10.1038/s41514-025-00228-x","url":null,"abstract":"Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both animal and patient levels. Based on microarray data of GSE122063, bioinformatic analysis revealed 502 DEGs in the frontal and 674 DEGs in the temporal cortex of VaD patients. Afterward, the hub genes between two regions, including C1QA, C1QB, C1QC, and C5AR1, were dugout. Interestingly, compared with sham mice or controls, the above four complements were highly expressed in the cortices of VaD animals and in the peripheral serum of VaD patients. Moreover, receiver operating characteristic curve analysis conformed to good diagnostic powers of these complements, with C1QB having the most prominent capacity (AUC = 0.799, 95%CI 0.722-0.875). That means the complements, especially subunits of C1Q, might be used as specific early VaD diagnostic biomarkers.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"42"},"PeriodicalIF":4.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 50-year journey in the development of treatment for benign prostatic hyperplasia. 良性前列腺增生治疗的50年历程。

IF 4.1

npj aging Pub Date : 2025-05-23 DOI: 10.1038/s41514-025-00231-2

Andrew V Schally, George Theodoropoulos, Wei Sha, Irving Vidaurre, Medhi Wangpaichitr

{"title":"A 50-year journey in the development of treatment for benign prostatic hyperplasia.","authors":"Andrew V Schally, George Theodoropoulos, Wei Sha, Irving Vidaurre, Medhi Wangpaichitr","doi":"10.1038/s41514-025-00231-2","DOIUrl":"10.1038/s41514-025-00231-2","url":null,"abstract":"Recent research underscores the crucial role of hormone regulation in benign prostatic hyperplasia (BPH) and the therapeutic promise of growth hormone-releasing hormone (GH-RH) antagonists. BPH incidence in aging men doubled over three decades, driven by prostatic enlargement and lower urinary tract symptoms (LUTS). Aging-related changes in GH-RH and luteinizing hormone-releasing hormone (LH-RH) biology promote BPH through hormonal and inflammatory processes. Traditional therapies provide symptomatic relief but often fail to prevent progression. This review explores the 50-year extensive development of LH-RH and GH-RH peptide analogs from discovery to delivery and their potential in BPH treatment. In preclinical studies, GH-RH antagonists reduced prostate volume, improved LUTS, and modulated inflammation mediated by NF-κB and IGF-I. Clinical trials are needed to validate antagonist efficacy and safety. Given BPH's public health impact among the aged, and especially among aging Veterans, integrating GH-RH antagonists into management strategies may offer precision-based therapeutic advancements.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"41"},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An epigenetic clock for Xenopus tropicalis. 热带非洲爪蟾的表观遗传时钟。

IF 6

npj aging Pub Date : 2025-05-22 DOI: 10.1038/s41514-025-00236-x

Ronan Bennett, Marco Morselli, Kseniya Petrova, Leonid Peshkin, Matteo Pellegrini

引用次数: 0

Sex-specific insights into drug-induced lifespan extension and weight loss in mice. 药物诱导小鼠寿命延长和体重减轻的性别特异性见解。

IF 4.1

npj aging Pub Date : 2025-05-19 DOI: 10.1038/s41514-025-00229-w

Aleksey V Belikov, Angelo Talay, João Pedro de Magalhães

引用次数: 0

Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening. 人工智能增强的可穿戴睡眠记录用于阿尔茨海默病筛查。

IF 4.1

npj aging Pub Date : 2025-05-09 DOI: 10.1038/s41514-025-00219-y

Elisabeth R M Heremans, Astrid Devulder, Pascal Borzée, Rik Vandenberghe, François-Laurent De Winter, Mathieu Vandenbulcke, Maarten Van Den Bossche, Bertien Buyse, Dries Testelmans, Wim Van Paesschen, Maarten De Vos

{"title":"Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening.","authors":"Elisabeth R M Heremans, Astrid Devulder, Pascal Borzée, Rik Vandenberghe, François-Laurent De Winter, Mathieu Vandenbulcke, Maarten Van Den Bossche, Bertien Buyse, Dries Testelmans, Wim Van Paesschen, Maarten De Vos","doi":"10.1038/s41514-025-00219-y","DOIUrl":"https://doi.org/10.1038/s41514-025-00219-y","url":null,"abstract":"The recent emergence of wearable devices will enable large scale remote brain monitoring. This study investigated whether multimodal wearable sleep recordings could help screening for Alzheimer's disease (AD). Measurements were acquired simultaneously from polysomnography and a wearable device, measuring electroencephalography (EEG) and accelerometry (ACM) in 67 elderly without cognitive symptoms and 35 AD patients. Sleep staging was performed using an AI model (SeqSleepNet), followed by feature extraction from hypnograms and physiological signals. Using these features, a multi-layer perceptron was trained for AD detection, with elastic net identifying key features. The wearable AD detection model achieved an accuracy of 0.90 (0.76 for prodromal AD). Single-channel EEG and ACM physiological features captured sufficient information for AD detection and outperformed the hypnogram features, highlighting these physiological features as promising discriminative markers for AD. We conclude that wearable sleep monitoring augmented by AI shows promise towards non-invasive screening for AD in the older population.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"34"},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing large language model performance related to aging in genetic conditions. 评估遗传条件下与衰老相关的大型语言模型性能。

IF 4.1

npj aging Pub Date : 2025-05-03 DOI: 10.1038/s41514-025-00226-z

Amna A Othman, Kendall A Flaharty, Suzanna E Ledgister Hanchard, Ping Hu, Dat Duong, Rebekah L Waikel, Benjamin D Solomon

{"title":"Assessing large language model performance related to aging in genetic conditions.","authors":"Amna A Othman, Kendall A Flaharty, Suzanna E Ledgister Hanchard, Ping Hu, Dat Duong, Rebekah L Waikel, Benjamin D Solomon","doi":"10.1038/s41514-025-00226-z","DOIUrl":"10.1038/s41514-025-00226-z","url":null,"abstract":"Most genetic conditions are described in pediatric populations, leaving a gap in understanding their clinical progression and management in adulthood. Motivated by other applications of large language models (LLMs), we evaluated whether Llama-2-70b-chat (70b) and GPT-3.5 (GPT) could generate plausible medical vignettes, patient-geneticist dialogues and management plans for a hypothetical child and adult patients across 282 genetic conditions (selected by prevalence and categorized based on age-related characteristics). Results showed that LLMs provided appropriate age-based responses in both child and adult outputs based on Correctness and Completeness scores graded by clinicians. Sub-analysis of metabolic conditions including those typically presents neonatally with crisis also showed age-appropriate LLM responses. However 70b and GPT obtained low Correctness and Completeness scores at producing plausible management plans (55-66% for 70b and a wider range, 50-90%, for GPT). This suggests that LLMs still have some limitations in clinical applications.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"33"},"PeriodicalIF":4.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects. 单细胞分析揭示了原花青素C1在造血免疫系统中通过衰老和同源效应的老年保护作用。

IF 4.1

npj aging Pub Date : 2025-05-02 DOI: 10.1038/s41514-025-00222-3

Xiuxing Liu, Yidan Liu, Yuehan Gao, Chun Zhang, Chenyang Gu, Jianjie Lv, Junying Wu, Wenru Su

{"title":"Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects.","authors":"Xiuxing Liu, Yidan Liu, Yuehan Gao, Chun Zhang, Chenyang Gu, Jianjie Lv, Junying Wu, Wenru Su","doi":"10.1038/s41514-025-00222-3","DOIUrl":"https://doi.org/10.1038/s41514-025-00222-3","url":null,"abstract":"Aging of hematopoietic and immune system (HIS) leads to cellular senescence and immune dysregulation, contributing to age-related diseases. Here, we show that Procyanidin C1 (PCC1), a compound with both senolytic and senomorphic properties, can counteract aging-related changes in HIS. Using single-cell RNA sequencing and validation experiments, we found that aging induced cellular senescence, inflammation, and immune dysregulation in the bone marrow and spleen tissues of mice. Long-term PCC1 treatment improved key physiological parameters especially the grip strength of aged mice. Further single-cell analysis revealed PCC1's broad geroprotective effects on HIS, including an increase in the proportion of B cells (BCs) and hematopoietic stem cells (HSCs), suppression of senescence-associated markers, and restoration of normal immune processes. Specifically, PCC1 mitigated inflammation and restored immune homeostasis in BCs by suppressing Cebpb expression and age-associated BCs. Moreover, PCC1 reversed aging-induced alterations in HSCs through upregulating Nedd4 and CD62L-Ca2+ axis expression. Finally, we identified senescent cells (SnCs) using machine learning and gene set enrichment analysis, revealing that PCC1 induced apoptosis of SnCs and regulated their metabolic processes, particularly in granulocytes and myeloid cells. The experimental validation further confirmed the senolytic and senomorphic effects of PCC1 both in vivo and in vitro. Overall, PCC1 holds potential as a therapeutic agent for alleviating immune dysfunction and promoting healthy aging via senolytic and senomorphic effects.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"31"},"PeriodicalIF":4.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0