npj aging最新文献_第3页

The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis. 髌下脂肪垫在炎症、膝关节健康和骨关节炎中的作用。

IF 4.1

npj aging Pub Date : 2024-07-15 DOI: 10.1038/s41514-024-00159-z

Magnolia G Wang, Patrick Seale, David Furman

引用次数: 0

Strategies for modeling aging and age-related diseases. 衰老和老年相关疾病建模策略。

IF 4.1

npj aging Pub Date : 2024-07-10 DOI: 10.1038/s41514-024-00161-5

D Jothi, Linda Anna Michelle Kulka

引用次数: 0

Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations. TgF344-AD 阿尔茨海默病大鼠模型缺省模式样网络中的节点度中心性作为早期网络改变的衡量标准。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00151-7

Saba Amiri, Monica van den Berg, Mohammad-Reza Nazem-Zadeh, Marleen Verhoye, Mahmood Amiri, Georgios A Keliris

{"title":"Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations.","authors":"Saba Amiri, Monica van den Berg, Mohammad-Reza Nazem-Zadeh, Marleen Verhoye, Mahmood Amiri, Georgios A Keliris","doi":"10.1038/s41514-024-00151-7","DOIUrl":"10.1038/s41514-024-00151-7","url":null,"abstract":"This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of Alzheimer's disease (AD) with application in the development of early diagnostic biomarkers of AD in translational studies. Thirteen male TgF344-AD (TG) rats, and eleven male wild-types (WT) littermates underwent longitudinal resting-state fMRI at the age of 4 and 6 months (pre and early-plaque stages of AD). Alterations in connectivity within DMLN were characterized by calculating the nodal degree (ND), a graph theoretical measure of centrality. The ND values of the left CA2 subregion of the hippocampus was found to be significantly lower in the 4-month-old TG cohort compared to the age-matched WT littermates. Moreover, a lower ND value (hypo-connectivity) was observed in the right prelimbic cortex (prL) and basal forebrain in the 6-month-old TG cohort, compared to the same age WT cohort. Indeed, the ND pattern in the DMLN in both TG and WT cohorts showed significant differences across the two time points that represent pre-plaque and early plaque stages of disease progression. Our findings indicate that lower nodal degree (hypo-connectivity) in the left CA2 in the pre-plaque stage of AD and hypo-connectivity between the basal forebrain and the DMLN regions in the early-plaque stage demonstrated differences in comparison to healthy controls. These results suggest that a graph-theoretical measure such as the nodal degree, can characterize brain networks and improve our insights into the mechanisms underlying Alzheimer's disease.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"29"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns. 对猕猴整个生命周期的转录组分析揭示了与年龄相关的免疫模式。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00158-0

Hyeon-Mu Cho, Se-Hee Choe, Ja-Rang Lee, Hye-Ri Park, Min-Gyeong Ko, Yun-Jung Lee, Hwal-Yong Lee, Sung Hyun Park, Sang-Je Park, Young-Hyun Kim, Jae-Won Huh

{"title":"Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns.","authors":"Hyeon-Mu Cho, Se-Hee Choe, Ja-Rang Lee, Hye-Ri Park, Min-Gyeong Ko, Yun-Jung Lee, Hwal-Yong Lee, Sung Hyun Park, Sang-Je Park, Young-Hyun Kim, Jae-Won Huh","doi":"10.1038/s41514-024-00158-0","DOIUrl":"10.1038/s41514-024-00158-0","url":null,"abstract":"Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristics of eight male healthy cynomolgus macaques, and the annual sampling was designed with two individuals in four age groups. As a laboratory animal, the macaques were meticulously shielded from all environmental factors except aging. The results showed recent findings of certain immune response and the age-associated network of primate immunity. Three important aging patterns were identified and each gene clusters represented a different immune response. The increased expression pattern was predominantly associated with innate immune cells, such as Neutrophils and NK cells, causing chronic inflammation with aging whereas the other two decreased patterns were associated with adaptive immunity, especially \"B cell activation\" affecting antibody diversity of aging. Furthermore, the hub gene network of the patterns reflected transcriptomic age and correlated with human illness status, aiding in future human disease prediction. Our macaque transcriptome profiling results offer systematic insights into the age-related immunological features of primates.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"30"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice. 动脉瘤Fibulin-4突变小鼠血管平滑肌细胞衰老加剧。

IF 4.1

npj aging Pub Date : 2024-06-20 DOI: 10.1038/s41514-024-00154-4

Sanne J M Stefens, Nicole van Vliet, Arne IJpma, Joyce Burger, Yunlei Li, Paula M van Heijningen, Jan H N Lindeman, Danielle Majoor-Krakauer, Hence J M Verhagen, Roland Kanaar, Jeroen Essers, Ingrid van der Pluijm

{"title":"Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.","authors":"Sanne J M Stefens, Nicole van Vliet, Arne IJpma, Joyce Burger, Yunlei Li, Paula M van Heijningen, Jan H N Lindeman, Danielle Majoor-Krakauer, Hence J M Verhagen, Roland Kanaar, Jeroen Essers, Ingrid van der Pluijm","doi":"10.1038/s41514-024-00154-4","DOIUrl":"10.1038/s41514-024-00154-4","url":null,"abstract":"Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used the aneurysmal Fibulin-4R/R mouse model to further unravel the underlying mechanisms of aneurysm formation. RNA sequencing of 3-month-old Fibulin-4R/R aortas revealed significant upregulation of senescence-associated secretory phenotype (SASP) factors and key senescence factors, indicating the involvement of senescence. Analysis of aorta histology and of vascular smooth muscle cells (VSMCs) in vitro confirmed the senescent phenotype of Fibulin-4R/R VSMCs by revealing increased SA-β-gal, p21, and p16 staining, increased IL-6 secretion, increased presence of DNA damage foci and increased nuclei size. Additionally, we found that p21 luminescence was increased in the dilated aorta of Fibulin-4R/R|p21-luciferase mice. Our studies identify a cellular aging cascade in Fibulin-4 aneurysmal disease, by revealing that Fibulin-4R/R aortic VSMCs have a pronounced SASP and a senescent phenotype that may underlie aortic wall degeneration. Additionally, we demonstrated the therapeutic effect of JAK/STAT and TGF-β pathway inhibition, as well as senolytic treatment on Fibulin-4R/R VSMCs in vitro. These findings can contribute to improved therapeutic options for aneurysmal disease aimed at reducing senescent cells.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"31"},"PeriodicalIF":4.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale and multidisciplinary analysis of aging processes in bone. 骨骼老化过程的多尺度和多学科分析。

npj aging Pub Date : 2024-06-15 DOI: 10.1038/s41514-024-00156-2

Linda Ravazzano, Graziana Colaianni, Anna Tarakanova, Yu-Bai Xiao, Maria Grano, Flavia Libonati

{"title":"Multiscale and multidisciplinary analysis of aging processes in bone.","authors":"Linda Ravazzano, Graziana Colaianni, Anna Tarakanova, Yu-Bai Xiao, Maria Grano, Flavia Libonati","doi":"10.1038/s41514-024-00156-2","DOIUrl":"10.1038/s41514-024-00156-2","url":null,"abstract":"The world population is increasingly aging, deeply affecting our society by challenging our healthcare systems and presenting an economic burden, thus turning the spotlight on aging-related diseases: exempli gratia, osteoporosis, a silent disease until you suddenly break a bone. The increase in bone fracture risk with age is generally associated with a loss of bone mass and an alteration in the skeletal architecture. However, such changes cannot fully explain increased fragility with age. To successfully tackle age-related bone diseases, it is paramount to comprehensively understand the fundamental mechanisms responsible for tissue degeneration. Aging mechanisms persist at multiple length scales within the complex hierarchical bone structure, raising the need for a multiscale and multidisciplinary approach to resolve them. This paper aims to provide an overarching analysis of aging processes in bone and to review the most prominent outcomes of bone aging. A systematic description of different length scales, highlighting the corresponding techniques adopted at each scale and motivating the need for combining diverse techniques, is provided to get a comprehensive description of the multi-physics phenomena involved.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study. 调查健康大脑老化的营养生物标志物：多模态大脑成像研究。

npj aging Pub Date : 2024-05-21 DOI: 10.1038/s41514-024-00150-8

Christopher E Zwilling, Jisheng Wu, Aron K Barbey

{"title":"Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study.","authors":"Christopher E Zwilling, Jisheng Wu, Aron K Barbey","doi":"10.1038/s41514-024-00150-8","DOIUrl":"10.1038/s41514-024-00150-8","url":null,"abstract":"The emerging field of Nutritional Cognitive Neuroscience aims to uncover specific foods and nutrients that promote healthy brain aging. Central to this effort is the discovery of nutrient profiles that can be targeted in nutritional interventions designed to promote brain health with respect to multimodal neuroimaging measures of brain structure, function, and metabolism. The present study therefore conducted one of the largest and most comprehensive nutrient biomarker studies examining multimodal neuroimaging measures of brain health within a sample of 100 older adults. To assess brain health, a comprehensive battery of well-established cognitive and brain imaging measures was administered, along with 13 blood-based biomarkers of diet and nutrition. The findings of this study revealed distinct patterns of aging, categorized into two phenotypes of brain health based on hierarchical clustering. One phenotype demonstrated an accelerated rate of aging, while the other exhibited slower-than-expected aging. A t-test analysis of dietary biomarkers that distinguished these phenotypes revealed a nutrient profile with higher concentrations of specific fatty acids, antioxidants, and vitamins. Study participants with this nutrient profile demonstrated better cognitive scores and delayed brain aging, as determined by a t-test of the means. Notably, participant characteristics such as demographics, fitness levels, and anthropometrics did not account for the observed differences in brain aging. Therefore, the nutrient pattern identified by the present study motivates the design of neuroscience-guided dietary interventions to promote healthy brain aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances and future trends of hormesis in disease. 疾病中激素作用的当前进展和未来趋势。

npj aging Pub Date : 2024-05-15 DOI: 10.1038/s41514-024-00155-3

Yantong Wan, Jinxi Liu, Yiyin Mai, Yinghao Hong, Zixuan Jia, Guijie Tian, Yunzhuo Liu, Huaping Liang, Jinghua Liu

{"title":"Current advances and future trends of hormesis in disease.","authors":"Yantong Wan, Jinxi Liu, Yiyin Mai, Yinghao Hong, Zixuan Jia, Guijie Tian, Yunzhuo Liu, Huaping Liang, Jinghua Liu","doi":"10.1038/s41514-024-00155-3","DOIUrl":"10.1038/s41514-024-00155-3","url":null,"abstract":"Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces a stimulatory effect, while higher doses may inhibit it. This phenomenon is widely observed across various organisms and stressors, significantly advancing our understanding and inspiring further exploration of the beneficial effects of toxins at doses both below and beyond traditional thresholds. This has profound implications for promoting biological regulation at the cellular level and enhancing adaptability throughout the biosphere. Therefore, conducting bibliometric analysis in this field is crucial for accurately analyzing and summarizing its current research status. The results of the bibliometric analysis reveal a steady increase in the number of publications in this field over the years. The United States emerges as the leading country in both publication and citation numbers, with the journal Dose-Response publishing the highest number of papers in this area. Calabrese E.J. is a prominent person with significant contributions and influence among authors. Through keyword co-occurrence and trend analysis, current hotspots in this field are identified, primarily focusing on the relationship between hormesis, oxidative stress, and aging. Analysis of highly cited references predicts that future research trends may center around the relationship between hormesis and stress at different doses, as well as exploring the mechanisms and applications of hormesis. In conclusion, this review aims to visually represent hormesis-related research through bibliometric methods, uncovering emerging patterns and areas of focus within the field. It provides a summary of the current research status and forecasts trends in hormesis-related research.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Healthcare on the brink: navigating the challenges of an aging society in the United States. 作者更正：濒临崩溃的医疗保健：迎接美国老龄化社会的挑战》。

npj aging Pub Date : 2024-05-10 DOI: 10.1038/s41514-024-00153-5

Charles H Jones, Mikael Dolsten

引用次数: 0

Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline. 正常老年人的脑萎缩将牙齿脱落和饮食变化与未来认知能力下降联系起来。

npj aging Pub Date : 2024-03-22 DOI: 10.1038/s41514-024-00146-4

Hiroyuki Nakamura, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Yutaka Kobayashi, Mikana Isa, Kentaro Ide, Toshihiro Kawano, Shuichi Kawashiri, Kazuhiro Uchida, Yasuko Tatewaki, Yasuyuki Taki, Tomoyuki Ohara, Toshiharu Ninomiya, Kenjiro Ono

{"title":"Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline.","authors":"Hiroyuki Nakamura, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Yutaka Kobayashi, Mikana Isa, Kentaro Ide, Toshihiro Kawano, Shuichi Kawashiri, Kazuhiro Uchida, Yasuko Tatewaki, Yasuyuki Taki, Tomoyuki Ohara, Toshiharu Ninomiya, Kenjiro Ono","doi":"10.1038/s41514-024-00146-4","DOIUrl":"10.1038/s41514-024-00146-4","url":null,"abstract":"Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclear. We conducted a population-based longitudinal cohort study in Nakajima, Nanao City, Japan. Between 2016 and 2018, 2454 residents aged ≥60 participated, covering 92.9% of the local age demographics. This study used comprehensive approach by combining detailed dental examinations, dietary assessments, magnetic resonance imaging (MRI) analysis, and cognitive evaluations. Tooth loss, even in cognitively normal individuals, is associated with parahippocampal gyrus atrophy and increased WMH volume, both of which are characteristics of dementia. Tooth loss was associated with altered dietary patterns, notably a reduction in plant-based food intake and an increase in fatty, processed food intake. This study highlights a possible preventative pathway where oral health may play a significant role in preventing the early neuropathological shifts associated with dementia.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0