npj aging最新文献_第4页

Identification of markers for neurescence through transcriptomic profiling of postmortem human brains. 通过对死后人类大脑的转录组学分析鉴定神经新生标志物。

IF 6

npj aging Pub Date : 2025-07-01 DOI: 10.1038/s41514-025-00235-y

Shiva Kazempour Dehkordi, Sogand Sajedi, Amirreza Heshmat, Miranda E Orr, Habil Zare

{"title":"Identification of markers for neurescence through transcriptomic profiling of postmortem human brains.","authors":"Shiva Kazempour Dehkordi, Sogand Sajedi, Amirreza Heshmat, Miranda E Orr, Habil Zare","doi":"10.1038/s41514-025-00235-y","DOIUrl":"10.1038/s41514-025-00235-y","url":null,"abstract":"Neuronal senescence (i.e., neurescence) is an important hallmark of aging and neurodegeneration, but it remains poorly characterized in the human brain due to the lack of reliable markers. This study aimed to identify neurescence markers based on single-nucleus transcriptome data from postmortem human prefrontal cortex. Using an eigengene approach, we integrated three gene panels: (a) SenMayo, (b) canonical senescence pathway (CSP), and (c) senescence initiating pathway (SIP), to identify neurescence signatures. We found that paired markers outperform single markers; for instance, by combining CDKN2D and ETS2 in a decision tree, a high accuracy of 99% and perfect specificity (100%) were achieved in distinguishing senescent neurons (i.e, neurescent). Differential expression analyses identified 324 genes that are overexpressed in neurescent. These genes showed significant associations with important neurodegeneration-related pathways, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Interestingly, several of these overexpressed genes are linked to mitochondrial dysfunction and cytoskeletal dysregulation. These findings provide valuable insights into the complexities of neurescence, emphasizing the need for further exploration of histologically viable markers and validation in broader datasets.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"57"},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging. 免疫代谢和氧化应激：在癌症和衰老中的作用和治疗策略。

IF 4.1

npj aging Pub Date : 2025-07-01 DOI: 10.1038/s41514-025-00250-z

Nan-Jie Zhou, Wei-Qian Bao, Cui-Fen Zhang, Meng-Lin Jiang, Tu-Liang Liang, Gang-Yuan Ma, Liang Liu, Hu-Dan Pan, Run-Ze Li

{"title":"Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging.","authors":"Nan-Jie Zhou, Wei-Qian Bao, Cui-Fen Zhang, Meng-Lin Jiang, Tu-Liang Liang, Gang-Yuan Ma, Liang Liu, Hu-Dan Pan, Run-Ze Li","doi":"10.1038/s41514-025-00250-z","DOIUrl":"10.1038/s41514-025-00250-z","url":null,"abstract":"Immunometabolism, encompassing metabolic processes within the immune system, plays a pivotal role in modulating the development, activity, and function of immune cells. Oxidative stress, resulting from an imbalance between pro-oxidants and antioxidants, is a critical factor in the pathogenesis of various diseases, including cancer and aging. This review synthesizes current knowledge on the interplay between immunometabolism and oxidative stress, highlighting their mechanisms in cancer progression and the aging process. We discuss how metabolic reprogramming in our body can influence immune cell function and promoting ageing and cancer development. Additionally, we examine the impact of aging on immune metabolism, leading to a decline in immune function and a predisposition to chronic diseases. The review also explores the potential of traditional Chinese medicine in targeting oxidative stress to delay aging and combat cancer, underscoring the need for further research to elucidate the molecular mechanisms underlying these effects. Our findings suggest that interventions targeting immunometabolism and oxidative stress could offer novel therapeutic avenues for cancer and aging-related diseases.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"59"},"PeriodicalIF":4.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy. 衰老生物标志物在预测流感病毒感染严重程度和疫苗接种效果方面的潜力

IF 4.1

npj aging Pub Date : 2025-07-01 DOI: 10.1038/s41514-025-00212-5

Jing Yang, Wei Ren, Yi Ren, Ting Yu, Liaqat Ali

{"title":"Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy.","authors":"Jing Yang, Wei Ren, Yi Ren, Ting Yu, Liaqat Ali","doi":"10.1038/s41514-025-00212-5","DOIUrl":"10.1038/s41514-025-00212-5","url":null,"abstract":"Influenza virus infection contributing to the majority of viral pneumonia, acute cardiovascular and renal co-morbidities even death, is a worldwide public health concern caused by seasonal and pandemic influenza viruses. Unlike seasonal influenza, which occurred annually, the emerging of pandemic influenza every two to three decades for the distinctly reassorted influenza virus strains contributed to the broadly rapid spread and increased morbidity and mortality. While the majority of the influenza-infected population manifest no or only moderate influenza like illnesses symptoms, partial would progress to severe influenza illness and even die for the influenza-triggered complications. In this view, we collect and recapitulate various biomarkers that have been identified and may be employed in the clinical practices involved detection, treatment, and protection of individuals with a high risk of progression to severe influenza illnesses, as well as accurate track monitoring of influenza illnesses prognosis and applicability of therapeutic strategies. While numerous influenza-related deaths occurred in the aging and frail population, the biomarkers associated with increased susceptibility to severe influenza illnesses among the aging and frail patients were retrieved and outlined. Aging intertwined with frailty, they have similar physiological function decline processes resulting in dysfunction of host defense mechanisms and increased infection-related co-morbidities. Overall, these potential biomarkers associated with aging, frailty conditions, and impaired immune defense mechanisms are determinant factors of influenza illness severity through combining the baseline background and tipping points, as well as socioeconomic status disparity and psychosocial vulnerability being the shifting the trajectory and outcomes of influenza illnesses, particularly among the elder individuals.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"56"},"PeriodicalIF":4.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome. 地中海饮食成分油酸减少老年牙周牙龈卟啉单胞菌感染的全身影响：解决应激抵抗和微生物组的作用。

IF 4.1

npj aging Pub Date : 2025-06-28 DOI: 10.1038/s41514-025-00248-7

Annika Döding, Ludwig Wurschi, Cristina Zubiria-Barrera, Tilman E Klassert, Leonhard Bereuter, Zhigang Rao, Ann-Kathrin Bär, Anton Domuncu, Andreas Koeberle, Heidi Noels, Hortense Slevogt, Bernd Sigusch, Ulrike Schulze-Späte

{"title":"Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome.","authors":"Annika Döding, Ludwig Wurschi, Cristina Zubiria-Barrera, Tilman E Klassert, Leonhard Bereuter, Zhigang Rao, Ann-Kathrin Bär, Anton Domuncu, Andreas Koeberle, Heidi Noels, Hortense Slevogt, Bernd Sigusch, Ulrike Schulze-Späte","doi":"10.1038/s41514-025-00248-7","DOIUrl":"10.1038/s41514-025-00248-7","url":null,"abstract":"Periodontitis (PD) is an age-associated infectious periodontal disease driven by dysbiosis and hyperinflammatory host response, resulting in bone and tissue loss. Often linked to systemic inflammatory comorbidities, modulating host response emerged as promising clinical target. This study investigates whether nutritional intervention mitigates age-associated systemic impact of oral infection with PD key pathogen Porphyromonas gingivalis. Young (5 weeks) and aged (≥73 weeks) mice received palmitic acid-enriched Western-diet (PA-ED) or Mediterranean-diet enriched with oleic acid (OA-ED), both known for immunomodulatory properties. PA-ED exacerbated oral bone loss and systemic effects, particularly in aged mice, correlated with gut microbiota destabilization and impaired stress responses. Further, PA-ED enhanced osteoclast differentiation and primed bone marrow cells towards inflammation. Contrarily, OA-ED mitigated these effects. Osteoblasts showed baseline inflammation and reduced responsiveness in aged mice, thereby promoting a pro-inflammatory micro-environment. Findings suggest OA-ED as protective, especially for the elderly, by limiting local and systemic tissue damage associated with PD.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"54"},"PeriodicalIF":4.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Senolytic effects of a modified Gingerenone A. 出版者更正：改良的姜酮a的衰老作用。

IF 4.1

npj aging Pub Date : 2025-06-23 DOI: 10.1038/s41514-025-00246-9

Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci

引用次数: 0

Multinational evaluation of AnthropoAge as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study. 在美国、英国、墨西哥、哥斯达黎加和中国，对AnthropoAge作为生物年龄测量的多国评估：一项基于人口的纵向研究。

IF 4.1

npj aging Pub Date : 2025-06-21 DOI: 10.1038/s41514-025-00232-1

Carlos A Fermín-Martínez, Daniel Ramírez-García, Neftali Eduardo Antonio-Villa, Jerónimo Perezalonso Espinosa, Diego Aguilar-Ramírez, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Jacqueline A Seiglie, Omar Yaxmehen Bello-Chavolla

{"title":"Multinational evaluation of AnthropoAge as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study.","authors":"Carlos A Fermín-Martínez, Daniel Ramírez-García, Neftali Eduardo Antonio-Villa, Jerónimo Perezalonso Espinosa, Diego Aguilar-Ramírez, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Jacqueline A Seiglie, Omar Yaxmehen Bello-Chavolla","doi":"10.1038/s41514-025-00232-1","DOIUrl":"10.1038/s41514-025-00232-1","url":null,"abstract":"We validated AnthropoAge, a biological age (BA) metric, for prediction of mortality and age-related outcomes using harmonized data from the US, England, Mexico, Costa Rica, and China. We estimated AnthropoAge and AnthropoAgeAccel as proxies of BA and age acceleration using body mass index and waist-to-height ratio. We compared mortality prediction of AnthropoAge vs. chronological age (CA) using Cox models and assessed its association with age-related outcomes with generalized estimating equations. Among 57,080 participants aged 50-94 years, AnthropoAgeAccel (c-statistic 0.806) improved mortality prediction of CA (0.803) and identified distinct aging trends for each country. Accelerated aging (AnthropoAgeAccel>0) increased mortality risk by ~37% independently of age and covariates, and predicted health deterioration, new deficits in activities of daily living, and age-related diseases. AnthropoAge is a robust BA metric with potential applications in identifying functional deficits, health decline, and mortality risk. However, it requires further validation and potential recalibration for broader applicability in underrepresented populations like Latin America.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"52"},"PeriodicalIF":4.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults. 粮食不安全改变了肠道微生物群与成人认知障碍风险之间的关系。

IF 6

npj aging Pub Date : 2025-06-18 DOI: 10.1038/s41514-025-00241-0

Shoshannah Eggers, Zachary E Hoggarth, Kiran Nagdeo, Maria J Banas, Jamil M Lane, Elza Rechtman, Chris Gennings, Elizabeth O'Neal, Paul E Peppard, Ajay K Sethi, Nasia Safdar, Kristen Mc Malecki, Amy A Schultz, Vishal Midya

{"title":"Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults.","authors":"Shoshannah Eggers, Zachary E Hoggarth, Kiran Nagdeo, Maria J Banas, Jamil M Lane, Elza Rechtman, Chris Gennings, Elizabeth O'Neal, Paul E Peppard, Ajay K Sethi, Nasia Safdar, Kristen Mc Malecki, Amy A Schultz, Vishal Midya","doi":"10.1038/s41514-025-00241-0","DOIUrl":"10.1038/s41514-025-00241-0","url":null,"abstract":"This study investigated the role of food insecurity as an effect modifier between the gut microbiome, including groups of microbes (cliques), and risk of cognitive impairment (RCI). The analytical sample (n = 360) included adult participants of the Survey of the Health of Wisconsin with complete data on food insecurity, RCI, and 16S rRNA sequencing from stool samples. Microbial cliques associated with RCI were identified using an interpretable machine-learning-based algorithm. All analyses were stratified by food insecurity level, and adjusted for relevant confounders. We identified two cliques whose associations with RCI were modified by food insecurity status. The presence of the clique with either Eisenbergiella or Eubacterium was more strongly associated with RCI for the food-insecure group (β = 0.29, p < 0.0001). A clique representing the presence of Ruminococcus torques, Bacteroides, CAG-352F, and/or Eubacterium had a stronger association with RCI for the food-secure group (β = 0.1, p < 0.0001). Findings suggest food security be considered in RCI etiology.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"47"},"PeriodicalIF":6.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise alters transcriptional profiles of senescence and gut barrier integrity in intestinal crypts of aging mice. 运动改变衰老小鼠肠隐窝中衰老和肠屏障完整性的转录谱。

IF 4.1

npj aging Pub Date : 2025-06-13 DOI: 10.1038/s41514-025-00242-z

Hyeonuk Jeon, Siyeon Lee, Yumin Kim, Yeongmin Kim, Soyeon Shin, Yoseob Lee, Minki Kim, Eunbin Ko, Eunsu Lee, Brian Min Song, Hojeong Choi, Nahee Hwang, Se-Eun Han, Byungjin Hwang, Jae-Woo Kim, Chang-Myung Oh, Sungsoon Fang

{"title":"Exercise alters transcriptional profiles of senescence and gut barrier integrity in intestinal crypts of aging mice.","authors":"Hyeonuk Jeon, Siyeon Lee, Yumin Kim, Yeongmin Kim, Soyeon Shin, Yoseob Lee, Minki Kim, Eunbin Ko, Eunsu Lee, Brian Min Song, Hojeong Choi, Nahee Hwang, Se-Eun Han, Byungjin Hwang, Jae-Woo Kim, Chang-Myung Oh, Sungsoon Fang","doi":"10.1038/s41514-025-00242-z","DOIUrl":"10.1038/s41514-025-00242-z","url":null,"abstract":"Senescence is the gradual process of aging in tissues and cells, and a primary cause of aging-associated diseases. Among them, intestinal stem cells (ISCs) experience exhaustion during aging, leading to reduced regenerative capacity in the intestinal crypt, which impairs intestinal function and contributes to systemic health issues. Given the critical role ISCs play in maintaining intestinal homeostasis, preventing their senescence is essential for preserving intestinal function. Among the various strategies proposed to slow cellular senescence, regular exercise has emerged as one of the most well-known and widely accepted interventions. Here, we examined how exercise affects the small intestine in an aging mouse model. Using single-cell RNA sequencing, we found that signaling pathways and gene expression related to DNA replication and cell cycle progression were upregulated in ISCs. Additionally, genes promoting ribosome biogenesis showed increased expression in both ISCs and transit amplifying cells. Exercise also recovered Wnt signaling inhibition, potentially influencing ISC differentiation. Furthermore, exercise increased Reg3g expression in Paneth cells and improved gut barrier function, contrasting with findings from a diet-induced obese mouse model. This suggests that regular exercise helps inhibit the aging of ISCs in multiple ways, contributing to the maintenance of intestinal homeostasis.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"51"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating EEG complexity and spectral signatures in Alzheimer's disease and frontotemporal dementia: evidence for rostrocaudal asymmetry. 评估阿尔茨海默病和额颞叶痴呆的脑电图复杂性和频谱特征：背侧-尾侧不对称的证据。

IF 4.1

npj aging Pub Date : 2025-06-09 DOI: 10.1038/s41514-025-00243-y

Kassra Ghassemkhani, Kevin S Saroka, Blake T Dotta

引用次数: 0

The role of physical activity in mitigating age-related changes in the neuromuscular control of gait. 体力活动在减轻与年龄相关的步态神经肌肉控制变化中的作用。

IF 4.1

npj aging Pub Date : 2025-06-09 DOI: 10.1038/s41514-025-00239-8

M N Núñez-Lisboa, A H Dewolf

{"title":"The role of physical activity in mitigating age-related changes in the neuromuscular control of gait.","authors":"M N Núñez-Lisboa, A H Dewolf","doi":"10.1038/s41514-025-00239-8","DOIUrl":"10.1038/s41514-025-00239-8","url":null,"abstract":"Exercise induces neural and muscular adaptations, improving muscle mass and function in older adults. We investigated its impact on gait neuromuscular control in young and older adults, classified as more active (young: n = 15, 5185 ± 1471 MET-min/week; old: n = 14, 6481 ± 4846 MET-min/week) or less active (young: n = 14, 1265 ± 965 MET-min/week; old: n = 14, 1473 ± 859 MET-min/week). Isometric maximal voluntary torques were assessed for proximal (knee) and distal (ankle) extensors, and muscle mechanical properties of these muscles were assessed using Myoton. Gait was analysed using ground reaction forces, motion capture, and electromyography. Less active older adults exhibited shorter steps, higher mechanical cost, and greater collision at heel strike. These differences were linked to altered neuromuscular control, wider activation of lumbar and sacral motor pools, different activation timing, and reduced muscle-tendon stiffness. Our findings highlight that physical activity preserves neuromuscular control, muscle mechanical properties, and gait efficiency, mitigating age-related decline.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"49"},"PeriodicalIF":4.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0