npj aging最新文献_第5页

STEMI-OP in-hospital mortality prediction algorithms: Frailty-integrated machine learning in older patients undergoing primary PCI. STEMI-OP住院死亡率预测算法：接受初级PCI的老年患者虚弱综合机器学习

IF 6

npj aging Pub Date : 2025-06-06 DOI: 10.1038/s41514-025-00238-9

Tan Van Nguyen, Quyen The Nguyen, Huong Quynh Nguyen, Nghia Thuong Nguyen, Khai Duc Luong, Lan Hoang Do Thi, Tu Cam Nguyen, Thuan Hoang Vo, Phan Huu Le, Phuc Thien Tran, Thanh Dinh Le

{"title":"STEMI-OP in-hospital mortality prediction algorithms: Frailty-integrated machine learning in older patients undergoing primary PCI.","authors":"Tan Van Nguyen, Quyen The Nguyen, Huong Quynh Nguyen, Nghia Thuong Nguyen, Khai Duc Luong, Lan Hoang Do Thi, Tu Cam Nguyen, Thuan Hoang Vo, Phan Huu Le, Phuc Thien Tran, Thanh Dinh Le","doi":"10.1038/s41514-025-00238-9","DOIUrl":"10.1038/s41514-025-00238-9","url":null,"abstract":"Despite advances in medical care, older patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) currently face high in-hospital mortality rates. Traditional prognostic models, primarily developed in Caucasian populations with fewer older participants and using classical statistical approaches, may not perform well in Southeast Asian settings. This study explores the need for artificial intelligence-based risk assessment models-the STEMI-OP algorithms-designed explicitly for STEMI patients aged 60 and older following primary PCI in Vietnam. Machine learning (ML) models were developed and validated using pre- and post-PCI features, with advanced feature selection techniques to identify key predictors. SHapley Additive exPlanations and Causal Random Forests were employed to improve interpretability and causal relationships between features and outcomes, highlighting the key factors, including the Killip classification, the Clinical Frailty Scale, glucose levels, and creatinine levels in predicting in-hospital mortality. The CatBoost model with ElasticNet regression for pre-PCI prediction and the Random Forest model with Ridge regression post-PCI prediction demonstrated significantly superior performance compared to traditional risk scores, achieving AUC values of 92.16% and 95.10%, respectively, outperforming the GRACE 2.0 score (83.48%) and the CADILLAC score (87.01%). By incorporating frailty and employing advanced ML techniques, the STEMI-OP algorithms produced more precise, personalized risk assessments that could enhance clinical decision-making and improve outcomes for older STEMI patients undergoing primary PCI.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"48"},"PeriodicalIF":6.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ageing is associated with exaggerated overstaying in foraging behaviour. 衰老与觅食行为中过度停留有关。

IF 4.1

npj aging Pub Date : 2025-05-30 DOI: 10.1038/s41514-025-00240-1

Noham Wolpe, Daniel N Scott, Mordechai L Salomon, Matthew R Nassar, Paul C Fletcher, Emilio Fernandez-Egea

{"title":"Ageing is associated with exaggerated overstaying in foraging behaviour.","authors":"Noham Wolpe, Daniel N Scott, Mordechai L Salomon, Matthew R Nassar, Paul C Fletcher, Emilio Fernandez-Egea","doi":"10.1038/s41514-025-00240-1","DOIUrl":"10.1038/s41514-025-00240-1","url":null,"abstract":"People constantly decide how much time to invest in rewarding activities. Foraging tasks assess this decision-making by measuring when individuals switch between contexts. People typically perform suboptimally in these tasks, largely due to overstaying, but it remains unclear whether this tendency changes with age independently of cognitive abilities and mental health factors. Previous research showing increased sensitivity to the opportunity cost of time in older adults predicts less overstaying, whereas a hypothesised shift towards exploitative behaviour predicts more overstaying. In an online foraging task, 350 young and older adults decided when to switch between contexts with varying reward conditions. We also assessed cognitive performance and self-reported motivation and depression. Participants consistently overstayed, and this behaviour was strongly associated with sensitivity to reward changes. Despite this, older adults selectively overstayed more without increased reward-based adaptation. Our findings show ageing is associated with exaggerated overstaying, supporting increased exploitative behaviour in old age.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"46"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senolytic effects of a modified Gingerenone A. 改性姜酮a的抗衰老作用。

IF 4.1

npj aging Pub Date : 2025-05-30 DOI: 10.1038/s41514-025-00230-3

Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci

{"title":"Senolytic effects of a modified Gingerenone A.","authors":"Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci","doi":"10.1038/s41514-025-00230-3","DOIUrl":"10.1038/s41514-025-00230-3","url":null,"abstract":"Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very few senotherapeutic (senolytics and senomorphics) compounds have been identified. In a recent study, we reported that gingerenone A (GinA) has a senolytic effect via mechanisms including the activation of caspase-3 activity and apoptotic cell death. In this study, we investigated whether GinA has senotherapeutic properties in a mouse model of senescence. Moreover, we modified GinA with eicosapentaenoic acid (EPA) esters (GinA-EPA) or docosahexaenoic acid (DHA) esters (GinA-DHA) to generate modified gingerenone A (modGinA) that could enhance GinA effects. We found that both GinA and modGinA induced biochemical and histological changes consistent with anti-inflammatory, senolytic, and senomorphic effects, leading to improved metabolic and mitochondrial functions.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging. 健康衰老中白质损伤体积与认知的皮质下脑容量差异。

IF 4.1

npj aging Pub Date : 2025-05-28 DOI: 10.1038/s41514-025-00234-z

Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander

{"title":"Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.","authors":"Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander","doi":"10.1038/s41514-025-00234-z","DOIUrl":"10.1038/s41514-025-00234-z","url":null,"abstract":"White matter hyperintensity (WMH) lesions associated with small vessel cerebrovascular disease (CVD) are common structural neuroimaging findings in older adults. Greater global brain WMH burden related to aging has been implicated in dementia but has also been linked to brain atrophy and cognitive dysfunction in old age. We sought to investigate the regionally distributed association of global WMH lesion load with subcortical gray matter (SGM) volumes using a multivariate network analysis method in 178 community-dwelling, healthy older adults (mean age = 69.77 ± 10.22 years). We additionally applied mediation models with WMH-related subcortical volumetric differences as a mediator to evaluate a potential global WMH-related vascular risk pathway leading to cognitive aging. Global WMH burden was associated with a regionally distributed pattern of SGM atrophy involving bilateral putamen and left nucleus accumbens, with relative volume increases in bilateral caudate nucleus. Mediation analyses revealed that increasing age predicted greater WMH-SGM pattern expression, which then predicted slowed processing speed that was, in turn, associated with decrements in other age-sensitive cognitive domains of memory, executive functioning, and fine motor function. These results suggest that the multivariate WMH-SGM pattern and its association with processing speed may provide an important early indicator of age-related decrements in higher-order cognitive processes, reflecting a potential link between CVD and broader cognitive dysfunction across multiple domains in healthy aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study. 二甲双胍可改善老年烧伤患者的不良结局：一项单中心队列研究。

IF 4.1

npj aging Pub Date : 2025-05-26 DOI: 10.1038/s41514-025-00224-1

Dalia Barayan, Fadi Khalaf, Sarah Rehou, Diana Julia Tedesco, Punit Bhattachan, Gregory Pond, Abdikarim Abdullahi, Marc G Jeschke

{"title":"Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study.","authors":"Dalia Barayan, Fadi Khalaf, Sarah Rehou, Diana Julia Tedesco, Punit Bhattachan, Gregory Pond, Abdikarim Abdullahi, Marc G Jeschke","doi":"10.1038/s41514-025-00224-1","DOIUrl":"10.1038/s41514-025-00224-1","url":null,"abstract":"This study assesses the safety and efficacy of metformin administration in older adult burn patients, a rapidly growing demographic with substantially poorer outcomes. This is a single-centre cohort study of older adults (≥60 years) admitted to a provincial burn center over 15 years. Clinical outcomes, laboratory measures, inflammatory markers, and adipose tissue single-nuclei RNA sequencing (SnRNA-seq) were compared among metformin-treated and non-treated controls. A total of 50 metformin-treated and 262 control older burn patients met the eligibility criteria. Despite pre-admission comorbidities, metformin-treated patients showed improved survival, no significant differences in the number of hypoglycemic episodes, a lower incidence of lactic acidosis, and reduced circulating levels of organ damage markers. SnRNA-Seq further revealed that metformin may exert its beneficial effects by local restoration of immune and inflammatory responses. In older burn patients, metformin was linked with improved outcomes and no adverse effects, underscoring its safety and efficacy in this population.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"43"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia. C1QA、C1QB、C1QC和C5AR1失调作为血管性痴呆的候选生物标志物。

IF 4.1

npj aging Pub Date : 2025-05-25 DOI: 10.1038/s41514-025-00228-x

Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi

{"title":"Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia.","authors":"Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi","doi":"10.1038/s41514-025-00228-x","DOIUrl":"10.1038/s41514-025-00228-x","url":null,"abstract":"Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both animal and patient levels. Based on microarray data of GSE122063, bioinformatic analysis revealed 502 DEGs in the frontal and 674 DEGs in the temporal cortex of VaD patients. Afterward, the hub genes between two regions, including C1QA, C1QB, C1QC, and C5AR1, were dugout. Interestingly, compared with sham mice or controls, the above four complements were highly expressed in the cortices of VaD animals and in the peripheral serum of VaD patients. Moreover, receiver operating characteristic curve analysis conformed to good diagnostic powers of these complements, with C1QB having the most prominent capacity (AUC = 0.799, 95%CI 0.722-0.875). That means the complements, especially subunits of C1Q, might be used as specific early VaD diagnostic biomarkers.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"42"},"PeriodicalIF":4.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 50-year journey in the development of treatment for benign prostatic hyperplasia. 良性前列腺增生治疗的50年历程。

IF 4.1

npj aging Pub Date : 2025-05-23 DOI: 10.1038/s41514-025-00231-2

Andrew V Schally, George Theodoropoulos, Wei Sha, Irving Vidaurre, Medhi Wangpaichitr

{"title":"A 50-year journey in the development of treatment for benign prostatic hyperplasia.","authors":"Andrew V Schally, George Theodoropoulos, Wei Sha, Irving Vidaurre, Medhi Wangpaichitr","doi":"10.1038/s41514-025-00231-2","DOIUrl":"10.1038/s41514-025-00231-2","url":null,"abstract":"Recent research underscores the crucial role of hormone regulation in benign prostatic hyperplasia (BPH) and the therapeutic promise of growth hormone-releasing hormone (GH-RH) antagonists. BPH incidence in aging men doubled over three decades, driven by prostatic enlargement and lower urinary tract symptoms (LUTS). Aging-related changes in GH-RH and luteinizing hormone-releasing hormone (LH-RH) biology promote BPH through hormonal and inflammatory processes. Traditional therapies provide symptomatic relief but often fail to prevent progression. This review explores the 50-year extensive development of LH-RH and GH-RH peptide analogs from discovery to delivery and their potential in BPH treatment. In preclinical studies, GH-RH antagonists reduced prostate volume, improved LUTS, and modulated inflammation mediated by NF-κB and IGF-I. Clinical trials are needed to validate antagonist efficacy and safety. Given BPH's public health impact among the aged, and especially among aging Veterans, integrating GH-RH antagonists into management strategies may offer precision-based therapeutic advancements.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"41"},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice. 衰老的代谢组学生物标志物：一项对雌性和雄性小鼠的纵向研究。

IF 4.1

npj aging Pub Date : 2025-05-23 DOI: 10.1038/s41514-025-00237-w

Dantong Zhu, Judy Z Wu, Patrick T Griffin, Brady A Samuelson, David A Sinclair, Alice E Kane

{"title":"Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.","authors":"Dantong Zhu, Judy Z Wu, Patrick T Griffin, Brady A Samuelson, David A Sinclair, Alice E Kane","doi":"10.1038/s41514-025-00237-w","DOIUrl":"10.1038/s41514-025-00237-w","url":null,"abstract":"Frailty is an age-related geriatric syndrome. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured frailty index and derived metabolomics data from plasma. We identify age-related differentially abundant metabolites, determine frailty-related metabolites, and generate frailty features, both in the whole cohort and sex-stratified subgroups. Using the features, we perform an association study and build a metabolomics-based frailty clock. We find that frailty-related metabolites are enriched for amino acid metabolism and metabolism of cofactors and vitamins, include ergothioneine, tryptophan and alpha-ketoglutarate, and present sex dimorphism. We identify B vitamin metabolism related flavin-adenine dinucleotide and pyridoxate as female-specific frailty biomarkers, and lipid metabolism related sphingomyelins, glycerophosphoethanolamine and glycerophosphocholine as male-specific frailty biomarkers. These associations are confirmed in a validation cohort, with ergothioneine and perfluorooctanesulfonate identified as robust frailty biomarkers. Our results identify sex-specific metabolite frailty biomarkers, and shed light on potential mechanisms.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"40"},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors. 诊断时的免疫老化决定了儿童白血病幸存者的t细胞恢复。

IF 4.1

npj aging Pub Date : 2025-05-23 DOI: 10.1038/s41514-025-00233-0

Kavita M Dhodapkar, Sharon Castellino, Shivani Kapadia, Maryam I Azeem, Ava Horvat, Taylor Lawrence, Deborah DeRyckere, Madhav V Dhodapkar

引用次数: 0

An epigenetic clock for Xenopus tropicalis. 热带非洲爪蟾的表观遗传时钟。

IF 6

npj aging Pub Date : 2025-05-22 DOI: 10.1038/s41514-025-00236-x

Ronan Bennett, Marco Morselli, Kseniya Petrova, Leonid Peshkin, Matteo Pellegrini

引用次数: 0