npj aging最新文献_第5页

Calcium (Ca²⁺) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS). 线粒体-内质网接触部位（MERCS）的钙（Ca2+）通量是治疗性衰老（TIS）中衰老溶解的新靶点。

IF 4.1

npj aging Pub Date : 2025-02-21 DOI: 10.1038/s41514-025-00197-1

Andrea Puebla-Huerta, Hernán Huerta, Camila Quezada-Gutierez, Pablo Morgado-Cáceres, César Casanova-Canelo, Sandra A Niño, Sergio Linsambarth, Osman Díaz-Rivera, José Alberto López-Domínguez, Sandra Rodríguez-López, José Antonio González-Reyes, Galdo Bustos, Eduardo Silva-Pavez, Alenka Lovy, Gabriel Quiroz, Catalina González-Seguel, Edison Salas-Huenuleo, Marcelo J Kogan, Jordi Molgó, Armen Zakarian, José M Villalba, Christian Gonzalez-Billault, Tito Calì, Ulises Ahumada-Castro, J César Cárdenas

{"title":"Calcium (Ca2+) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS).","authors":"Andrea Puebla-Huerta, Hernán Huerta, Camila Quezada-Gutierez, Pablo Morgado-Cáceres, César Casanova-Canelo, Sandra A Niño, Sergio Linsambarth, Osman Díaz-Rivera, José Alberto López-Domínguez, Sandra Rodríguez-López, José Antonio González-Reyes, Galdo Bustos, Eduardo Silva-Pavez, Alenka Lovy, Gabriel Quiroz, Catalina González-Seguel, Edison Salas-Huenuleo, Marcelo J Kogan, Jordi Molgó, Armen Zakarian, José M Villalba, Christian Gonzalez-Billault, Tito Calì, Ulises Ahumada-Castro, J César Cárdenas","doi":"10.1038/s41514-025-00197-1","DOIUrl":"10.1038/s41514-025-00197-1","url":null,"abstract":"Therapy-induced senescence (TIS) alters calcium (Ca²⁺) flux and Mitochondria-ER Contact Sites (MERCS), revealing critical vulnerabilities in senescent cells. In this study, TIS was induced using Doxorubicin and Etoposide, resulting in an increased MERCS contact surface but a significant reduction in ER-mitochondria Ca²⁺ flux. Mechanistically, TIS cells exhibit decreased expression of IP3R isoforms and reduced interaction between type 1 IP3R and VDAC1, impairing Ca²⁺ transfer. This flux is crucial for maintaining the viability of senescent cells, highlighting its potential as a therapeutic target. Inhibition of ER-mitochondria Ca²⁺ flux demonstrates senolytic effects both in vitro and in vivo, offering a novel strategy for targeting senescent cells.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"11"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early vascular aging ambulatory score in acute ischemic stroke. 急性缺血性脑卒中早期血管老化动态评分。

IF 4.1

npj aging Pub Date : 2025-02-21 DOI: 10.1038/s41514-025-00202-7

Nikolaos Kakaletsis, Vasilios Kotsis, Naohisa Hosomi, Tomohisa Nezu, Patrik Michel, Thevoz Guillaume, Davide Strambo, Young Seo Kim, Wonjae Sung, Konstantinos Vemmos, Eleni Korompoki, Maurizio Acampa, Jukka Putaala, Lauri Tulkki, Matthias Hermann, Protazy Rejmer, Philip M Bath, Lisa J Woodhouse, Athanase D Protogerou, Elpida Athanasopoulou, Haralampos Milionis, George Ntaios, Christos Savopoulos

{"title":"Early vascular aging ambulatory score in acute ischemic stroke.","authors":"Nikolaos Kakaletsis, Vasilios Kotsis, Naohisa Hosomi, Tomohisa Nezu, Patrik Michel, Thevoz Guillaume, Davide Strambo, Young Seo Kim, Wonjae Sung, Konstantinos Vemmos, Eleni Korompoki, Maurizio Acampa, Jukka Putaala, Lauri Tulkki, Matthias Hermann, Protazy Rejmer, Philip M Bath, Lisa J Woodhouse, Athanase D Protogerou, Elpida Athanasopoulou, Haralampos Milionis, George Ntaios, Christos Savopoulos","doi":"10.1038/s41514-025-00202-7","DOIUrl":"10.1038/s41514-025-00202-7","url":null,"abstract":"Understanding the impact of early vascular aging (EVA) on acute ischemic stroke (AIS) outcomes may provide new insights for improving prognostic assessments and developing targeted therapeutic strategies. This study aimed to validate the EVA ambulatory score (EVAAs) in AIS patients, assessing its association with stroke type, severity, and prognosis. Among the 2,730 AIS patients with a mean age of 72.0 ± 14.4 years, 83.4% exhibited EVA. EVA was identified as an independent predictor of poor outcome at both discharges (aOR:1.72, 95%CI:1.25-2.36, p < 0.001) and at 90 days (aOR:2.22, 95%CI:1.49-3.31, p < 0.001). In subgroup analyses, EVAAs showed improved predictive value in AIS patients with a lower cardiovascular disease burden and a non-atherogenic lipid profile. The EVAAs, as an indicator of EVA that could be easily integrated into daily clinical practice, are a significant predictor of adverse outcomes in AIS patients.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"13"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of senescence and nuclear reorganization in aging gingival cells. 老化牙龈细胞的衰老特征和核重组。

IF 4.1

npj aging Pub Date : 2025-02-21 DOI: 10.1038/s41514-025-00200-9

Christian Fernández, Diego Ormeno, Verónica Villalobos, Mauricio Garrido, Javiera Canelo, Oscar Cerda, Felipe Maldonado, Mónica Caceres

{"title":"Characterization of senescence and nuclear reorganization in aging gingival cells.","authors":"Christian Fernández, Diego Ormeno, Verónica Villalobos, Mauricio Garrido, Javiera Canelo, Oscar Cerda, Felipe Maldonado, Mónica Caceres","doi":"10.1038/s41514-025-00200-9","DOIUrl":"10.1038/s41514-025-00200-9","url":null,"abstract":"Cellular senescence is a stress response that limits tumor formation by promoting the removal of damaged cells through the immune system. In this study, we observed accumulation of senescent cells during human aging gingival tissue, by increased levels of γH2A.X, 53BP1, and SAHF, along with a greater distance of H3K9me3 from the nuclear periphery. Additionally, primary gingival fibroblasts from older individuals displayed an enlarged nuclear area and perimeter, accompanied by DNA damage responses and increased Lamin B1 invaginations. The combination of phospho-p38 (Thr180/Tyr182) foci with form factor demonstrated an 79.27% predictive accuracy for aging in gingival fibroblasts, with an AUC of 0.83. In co-culture experiments, our findings revealed that senescent fibroblasts from aged donors exhibit slower and fewer recruitment of PBMCs and decreased levels of the Natural Killer cell receptor ligand MICA/B and the CD112R ligand Nectin-2, suggesting potential impairment in immune surveillance mechanisms during aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"12"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PTP-3 regulated by VB12 is important for ageing health in C. elegans. VB12调控的PTP-3在秀丽隐杆线虫衰老健康中起重要作用。

IF 4.1

npj aging Pub Date : 2025-02-21 DOI: 10.1038/s41514-025-00201-8

Man Zhu, Tao Lv, Mei Peng, Huifang Sun, Yuhong Li

引用次数: 0

Author Correction: Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy. 作者更正：长期摄入青菇（平菇）可减轻与年龄相关的心血管功能障碍，延长健康预期寿命。

IF 4.1

npj aging Pub Date : 2025-02-19 DOI: 10.1038/s41514-025-00196-2

Michio Sato, Daisuke Torigoe, Yuya Kinoshita, Momoka Cyuman, Chitoku Toda, Masaru Sato, Kazutaka Ikeda, Tsuyoshi Kadomatsu, Haruki Horiguchi, Jun Morinaga, Hirotaka Fukami, Taichi Sugizaki, Keishi Miyata, Ryoko Kusaba, Yusuke Okadome, Eiji Matsunaga, Koichi Node, Yuichi Oike

引用次数: 0

Innovations in aging biology: highlights from the ARDD emerging science & technologies workshop. 衰老生物学的创新：ARDD新兴科学与技术研讨会的亮点。

IF 4.1

npj aging Pub Date : 2025-02-18 DOI: 10.1038/s41514-025-00193-5

Maximilian Unfried, Tomas Schmauck-Medina, Neal D Amin, Edward S Boyden, Georg Fuellen, Jing-Dong Jackie Han, Jacob H Hanna, Indra Heckenbach, Konstantin Khodosevich, Lisa Melton, Emad Moeendarbary, Tae Seok Moon, Shahaf Peleg, Anders Sandberg, Lingyan Shi, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen

引用次数: 0

Reclassification of the conventional risk assessment for aging-related diseases by electrocardiogram-enabled biological age. 通过心电图激活的生物年龄对衰老相关疾病的传统风险评估进行重新分类。

IF 4.1

npj aging Pub Date : 2025-02-06 DOI: 10.1038/s41514-025-00198-0

Chih-Min Liu, Ming-Jen Kuo, Chin-Yu Kuo, I-Chien Wu, Pei-Fen Chen, Wan-Ting Hsu, Li-Lien Liao, Shih-Ann Chen, Hsuan-Ming Tsao, Chien-Liang Liu, Yu-Feng Hu

{"title":"Reclassification of the conventional risk assessment for aging-related diseases by electrocardiogram-enabled biological age.","authors":"Chih-Min Liu, Ming-Jen Kuo, Chin-Yu Kuo, I-Chien Wu, Pei-Fen Chen, Wan-Ting Hsu, Li-Lien Liao, Shih-Ann Chen, Hsuan-Ming Tsao, Chien-Liang Liu, Yu-Feng Hu","doi":"10.1038/s41514-025-00198-0","DOIUrl":"10.1038/s41514-025-00198-0","url":null,"abstract":"An artificial intelligence (AI)-enabled electrocardiogram (ECG) model has been developed in a healthy adult population to predict ECG biological age (ECG-BA). This ECG-BA exhibited a robust correlation with chronological age (CA) in healthy adults and additionally significantly enhanced the prediction of aging-related diseases' onset in adults with subclinical diseases. The model showed particularly strong predictive power for cardiovascular and non-cardiovascular diseases such as stroke, coronary artery disease, peripheral arterial occlusive disease, myocardial infarction, Alzheimer's disease, osteoarthritis, and cancers. When combined with CA, ECG-BA improved diagnostic accuracy and risk classification by 21% over using CA alone, notably offering the greatest improvements in cancer prediction. The net reclassification improvement significantly reduced misclassification rates for disease onset predictions. This comprehensive study validates ECG-BA as an effective supplement to CA, advancing the precision of risk assessments for aging-related conditions and suggesting broad implications for enhancing preventive healthcare strategies, potentially leading to better patient outcomes.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"7"},"PeriodicalIF":4.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senolytic compounds reduce epigenetic age of blood samples in vitro. 体外抗衰老化合物降低血液样本的表观遗传年龄。

IF 4.1

npj aging Pub Date : 2025-02-04 DOI: 10.1038/s41514-025-00199-z

Vithurithra Tharmapalan, Miriam Du Marchie Sarvaas, Michael Bleichert, Martina Wessiepe, Wolfgang Wagner

引用次数: 0

Knee adipose tissue: from its implication in osteoarthritis to its supposed role in tissue engineering. 膝关节脂肪组织：从它在骨关节炎中的含义到它在组织工程中的假定作用。

IF 4.1

npj aging Pub Date : 2025-02-03 DOI: 10.1038/s41514-025-00195-3

Elena Stocco, Aron Emmi, Raffaele De Caro, Andrea Porzionato, Veronica Macchi

引用次数: 0

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control. NAD World 3.0: NMN转运体和eNAMPT在哺乳动物衰老和长寿控制中的重要性。