Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci
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引用次数: 0
摘要
衰老细胞随着年龄的增长而积累，并与几种与年龄相关的疾病和功能衰退有关。用抗衰老剂消除衰老细胞可改善小鼠模型中的衰老表型，并可能改善慢性疾病患者的健康。到目前为止，很少有老年治疗（抗衰老和抗衰老）化合物已被确定。在最近的一项研究中，我们报道了gingerenone a （GinA）通过激活caspase-3活性和凋亡细胞死亡等机制具有衰老作用。在这项研究中，我们研究了GinA在衰老小鼠模型中是否具有衰老治疗特性。此外，我们用二十碳五烯酸（EPA）酯（GinA-EPA）或二十二碳六烯酸（DHA）酯（GinA-DHA）对GinA进行修饰，得到了可以增强GinA作用的改性姜酮A （modGinA）。我们发现，GinA和modGinA诱导的生化和组织学变化与抗炎、抗衰老和同形效应一致，导致代谢和线粒体功能的改善。
Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very few senotherapeutic (senolytics and senomorphics) compounds have been identified. In a recent study, we reported that gingerenone A (GinA) has a senolytic effect via mechanisms including the activation of caspase-3 activity and apoptotic cell death. In this study, we investigated whether GinA has senotherapeutic properties in a mouse model of senescence. Moreover, we modified GinA with eicosapentaenoic acid (EPA) esters (GinA-EPA) or docosahexaenoic acid (DHA) esters (GinA-DHA) to generate modified gingerenone A (modGinA) that could enhance GinA effects. We found that both GinA and modGinA induced biochemical and histological changes consistent with anti-inflammatory, senolytic, and senomorphic effects, leading to improved metabolic and mitochondrial functions.
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