Neurorehabilitation and neural repair最新文献

{"title":"2024 Reviewer Thank You.","authors":"","doi":"10.1177/15459683251320714","DOIUrl":"https://doi.org/10.1177/15459683251320714","url":null,"abstract":"","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":"39 3","pages":"256-258"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Repetitive Transcranial Magnetic Stimulation on Poststroke Hemineglect: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.","authors":"Fu-An Yang, Chueh-Ho Lin, Hung-Ning Chung, Yi-Chun Kuan, Reuben Escorpizo, Hung-Chou Chen","doi":"10.1177/15459683241309572","DOIUrl":"10.1177/15459683241309572","url":null,"abstract":"<p><p>BackgroundAlthough various repetitive transcranial magnetic stimulation (rTMS) and theta burst stimulation (TBS) protocols are used, their comparative effectiveness for treating poststroke hemineglect remains unassessed.ObjectiveTo investigate rTMS and TBS effects on clinical outcomes in poststroke hemineglect through a systematic review and network meta-analysis.MethodsWe searched PubMed, EMBASE, and Cochrane Library databases up to March 7, 2024, for trials on rTMS or TBS in poststroke hemineglect. Included studies involved rTMS or TBS with different protocols, sham, or no stimulation, assessing hemineglect severity or impact. The quality of the included studies was evaluated using the PEDro scale. The network meta-analysis was performed using ShinyNMA (version 1.01).ResultsWe analyzed 13 studies with 309 participants. All studies included participants who had experienced right hemisphere stroke. All included studies had a fair to good quality based on PEDro score evaluation. Protocols included continuous TBS (cTBS), high-frequency rTMS (HF-rTMS), and low-frequency rTMS (LF-rTMS) targeting both contralesional and lesional sites. HF-rTMS on the lesional site significantly improved short-term results on the line bisection test and Catherine Bergego Scale; LF-rTMS on the contralesional site improved short-term line bisection; and cTBS on the contralesional site improved long-term line bisection. No severe adverse events or significant inconsistencies were reported.ConclusionsOur findings indicate that HF-rTMS targeting the lesional site is the preferred therapeutic approach for the short-term management of poststroke hemineglect. LF-rTMS directed at the contralesional site is a practical alternative. Moreover, cTBS targeting the contralesional site is a viable option because of its long-term effect.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"190-201"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cell Biology in Peripheral Nervous System Injury.","authors":"Yiming Xia, Min Cai, Yiyue Zhou, Yi Yao, Maorong Jiang, Dandan Gu, Dengbing Yao","doi":"10.1177/15459683241304325","DOIUrl":"10.1177/15459683241304325","url":null,"abstract":"<p><strong>Background: </strong>The peripheral nervous system (PNS) exhibits remarkable regenerative capability after injury. PNS regeneration relies on neurons themselves as well as a variety of other cell types, including Schwann cells, immune cells, and non-neuronal cells.</p><p><strong>Objectives: </strong>This paper focuses on summarizing the critical roles of immune cells (SCs) in the injury and repair processes of the PNS.</p><p><strong>Results: </strong>During peripheral nerve injury, macrophages infiltrate the site under the induction of various cytokines, primarily accumulating at the dorsal root ganglia (DRG) and the nerve distal to the injury site, with only a small number detected at the nerve proximal to the injury site. The phenotype of macrophages during injury remains controversial, but recent single-cell sequencing analyses may provide new insights. In peripheral nervous system injury, macrophages participate in Wallerian degeneration as well as in the reconstruction of nerve bridges and angiogenesis during axonal regeneration. Neutrophils appear early in the injury process and are primarily present at the injury site and the distal segment. After peripheral nervous system injury, immature neutrophils from the peripheral blood play a major role. Although lymphocytes constitute only a small fraction compared to macrophages and neutrophils after peripheral nervous system injury, they still play important roles, including Treg cells, B cells, and NK cells. A large number of immune cells accumulate at the injury site, contributing not only to Wallerian degeneration but also to axonal regeneration.</p><p><strong>Conclusion: </strong>In conclusion, this paper summarizes current knowledge regarding the mechanisms of immune cell infiltration after PNS injury, providing new insights for future research on the role of immune cells in peripheral nerve injury.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"230-240"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Reviewer Thank You.","authors":"","doi":"10.1177/15459683251320714","DOIUrl":"https://doi.org/10.1177/15459683251320714","url":null,"abstract":"","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251320714"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Relevance of the Tonic Stretch Reflex Threshold and μ as Measures of Upper Limb Spasticity and Motor Impairment After Stroke.","authors":"Daniele Piscitelli, Joy Khayat, Anatol G Feldman, Mindy F Levin","doi":"10.1177/15459683251318689","DOIUrl":"https://doi.org/10.1177/15459683251318689","url":null,"abstract":"<p><strong>Background: </strong>After a central nervous system lesion, the ability to control muscle activation and relaxation in specific joint ranges may be impaired. The underlying mechanism of this sensorimotor impairment is related to a decreased ability to regulate the tonic stretch reflex threshold (TSRT) through descending and peripheral control processes. In dynamics, the reflex threshold and its velocity-sensitivity (μ) describe how movement in specific upper limb (UL) joint ranges is impaired after stroke.</p><p><strong>Objective: </strong>To examine the relationships between measures of elbow flexor impairment using TSRT and μ, and clinical scores of spasticity and motor function. We hypothesized that TSRT and μ would be related to clinical spasticity and motor impairment scores in patients with acute and chronic stroke.</p><p><strong>Methods: </strong>TSRT, μ, and clinical data of the resistance to passive movement (Modified Ashworth Scale) and UL motor function (Fugl-Meyer Assessment [FMA]) were collected from 120 patients. Relationships between variables were determined using simple correlations and multiple regression analysis.</p><p><strong>Results: </strong>TSRT and μ explained 72.0% of the variance in the FMA of the Upper Extremity [FMA-UE] describing only in-synergy and out-of-synergy movements and reflex function. TSRT explained 68.7% of the variance in the total score of the FMA-UE.</p><p><strong>Conclusions: </strong>This study shows for the first time, a significant relationship between deficits in TSRT regulation and μ with UL motor impairment after stroke. TSRT and μ may be valuable clinical biomarkers of sensorimotor impairment for monitoring spontaneous or treatment-induced motor recovery.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251318689"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Phase Multiple Sclerosis Patients Present Substantial Deficits in Physical-, Cognitive-, and Patient-reported Outcomes Compared to Matched Healthy Controls.","authors":"Cecilie Thrue, Lars G Hvid, Mette Diechmann, Tobias Gaemelke, Egon Stenager, Ulrik Dalgas, Morten Riemenschneider","doi":"10.1177/15459683251318246","DOIUrl":"https://doi.org/10.1177/15459683251318246","url":null,"abstract":"<p><strong>Background: </strong>Early identification of potential deficits is of utmost importance as early diagnosis and early treatment has been shown to be crucial to reduce disease activity and disease impact-leading to the notion of \"Time matters\" in multiple sclerosis (MS).</p><p><strong>Objective: </strong>The aim of the present study was to compare physical-, cognitive-, and patient-reported outcomes in early phase MS patients with matched healthy controls (HC).</p><p><strong>Methods: </strong>This cross-sectional study included 84 patients early in the disease course of MS (≤2 years from diagnosis) and 84 age- and sex-matched HC. All participants underwent a comprehensive test battery including physical-, cognitive-, and patient-reported outcomes.</p><p><strong>Results: </strong>Relative deficits for patients with MS compared to HC corresponded to 7% to 35% in walking capacity (Timed 25-Foot Walk Test, 6 Spot Step Test, 6 Minute Walk Test), 5% for upper limb function (9 Hole Peg Test), 27% for aerobic capacity (maximal oxygen uptake), 17% to 38% for physical activity level (Baecke Sport Index and accelerometer counts/minute), 68% for fatigability (Walking Fatigability Index), 150% for fatigue (Modified Fatigue Impact Scale), 4% to 20% for cognitive function (Symbol Digit Modalities Test, Paced Auditory Serial Addition Test, and Selective Reminding Test), and lastly, 7% to 8% for quality of life (Short Form-36 health survey). Only the Symbol Digit Modalities Test and Selective Reminding Test Delayed did not differ between groups, statistically.</p><p><strong>Conclusion: </strong>Early phase MS patients present substantial deficits in physical-, cognitive-, and patient-reported outcomes compared to HC. These early impairments highlight the importance of early initiatives aimed at preserving and/or building of reserve capacity.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251318246"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Extremity-Cognitive Dual-Task Capacity Post-Stroke.","authors":"Yishai Bachar Kirshenboim, Shir Tzur Lebovich, Tal Weitzer, Dana Doron, Moshe Bondi, Ron Cialic, Debbie Rand","doi":"10.1177/15459683251317192","DOIUrl":"https://doi.org/10.1177/15459683251317192","url":null,"abstract":"<p><strong>Background: </strong>Dual-task capacity, which might be impaired poststroke, is needed for daily functions. Therefore, dual-task capacity should be assessed during rehabilitation. The Dual Overload Interference Test (DO-IT) is a new upper extremity (UE) protocol for assessment, combining The Box and Block Test with the Counting Backwards Test.</p><p><strong>Objectives: </strong>To validate DO-IT by comparing between (1) young and older healthy, (2) stroke and healthy participants. Additionally, to correlate DO-IT with (3) walking-cognitive dual-task assessment (healthy), and (4) standardized cognitive and EF assessments (stroke).</p><p><strong>Methods: </strong>A cross-sectional study included younger and older community-dwelling healthy individuals (N = 32), and younger and older individuals with stroke (N = 83). DO-IT was administered to all participants. The #blocks transferred (motor) and #correct numbers counted (cognitive) were recorded for single and dual conditions. The walking-cognitive dual-task test was administered to the healthy participants. Motor and cognitive costs were calculated as the difference between single and dual tasks. The Montreal Cognitive Assessment test (MoCA) and the Color Trail Test (CTT) assessed cognition post stroke.</p><p><strong>Results: </strong>Older healthy adults had significantly lower dual-task motor capacity compared to younger adults (median [interquartile range] blocks: older 26 [21-38], younger 46 [38-52], <i>P</i> < .01). Participants with stroke showed higher motor costs than healthy participants. Dual-task costs correlated between DO-IT to walking-cognitive (motor; <i>r</i> = .37-.41, cognitive; <i>r</i> = .41-.47, <i>P</i> < .05). DO-IT motor cost negatively correlated with MoCA (<i>r</i> = -.27, <i>P</i> < .05), and DO-IT motor performance correlated with MoCA/CTT-AB (<i>r</i> = .29-.60, <i>P</i> < .05).</p><p><strong>Conclusions: </strong>UE-Cognitive dual-task capacity is affected post-stroke. DO-IT shows potential for use in stroke rehabilitation and its validity should be further researched.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251317192"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talking While Walking After Concussion: Acute Effects of Concussion on Speech Pauses and Gait Speed.","authors":"Shu Yang, Paula K Johnson, Colby R Hansen, Elisabeth A Wilde, Melissa M Cortez, Leland E Dibble, Peter C Fino, Tiphanie E Raffegeau","doi":"10.1177/15459683251317184","DOIUrl":"10.1177/15459683251317184","url":null,"abstract":"<p><strong>Background: </strong>Deficits in dual-tasks (DT) are frequently observed post-concussion (ie, mild Traumatic Brain Injury). However, traditional DT may not be relevant to daily life. Walking while talking elicits DT costs in healthy adults and is part of daily life.</p><p><strong>Objective: </strong>We investigated the effect of concussion on walking with extemporaneous speech and explored relationships between DT and acute symptoms.</p><p><strong>Methods: </strong>Participants with recent concussion (<14 days post-injury) and controls completed 3 tasks: single-task gait without speaking (ST_G), single-task speaking without walking (ST_S), and walking while speaking (DT). Silent pauses in speech audio reflected cognitive performance, and gait was quantified using inertial sensors. We used linear mixed models to compare groups and conditions and explored associations with self-reported symptoms.</p><p><strong>Results: </strong>Both concussion (n = 19) and control (n = 18) groups exhibited longer speech pauses (<i>P</i> < .001), slower walking speeds (<i>P</i> < .001), and slower cadence (<i>P</i> < .001) during the DT compared to ST conditions. There were no group differences or interactions for speech pauses (<i>P</i> > .424). The concussion group slowed down more during DT than the control group (group × task <i>P</i> = .032). Vestibular symptoms strongly associated with ST speech pause duration (ρ = .72), ST gait speed (ρ = -.75), and DT gait speed (ρ = -.78).</p><p><strong>Conclusions: </strong>Extemporaneous speech is well-practiced but challenging to complete while walking post-concussion. Strong associations between DT outcomes and vestibular-related symptoms suggest DT deficits vary with post-concussion symptomology. DT deficits may be deleterious to daily tasks post-concussion.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251317184"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Intensity Interval Training POst-STroke (HIIT-POST): Perspectives of People Living With Stroke and Health Professionals.","authors":"Sarah K Ashcroft, Liam Johnson, Suzanne S Kuys, Angelica G Thompson-Butel","doi":"10.1177/15459683251317185","DOIUrl":"10.1177/15459683251317185","url":null,"abstract":"<p><strong>Background: </strong>High intensity interval training (HIIT) is a mode of aerobic exercise that can increase neurotrophin concentration, improve cardiovascular health, and enhance recovery post-stroke. However, HIIT is not commonly prescribed in stroke rehabilitation. Exploring the clinical utility of, and barriers and facilitators to, HIIT is necessary to optimize clinical use.</p><p><strong>Objective: </strong>To identify perceptions of HIIT from people with stroke and health professionals working in stroke rehabilitation.</p><p><strong>Methods: </strong>People with stroke and health professionals in Australia were invited to participate in an online questionnaire. Participants were further invited to complete a one-on-one semi-structured interview. A Framework Analysis approach was applied to identify key themes.</p><p><strong>Results: </strong>Twenty-six people with stroke (mean ± standard deviation = 49.2 ± 60.6 months post-stroke, 57.7% female) and 37 health professionals (2 medical and 35 allied health) completed questionnaires. Ten people with stroke (5 female) and 8 allied health professionals completed an interview. Aerobic exercise was not considered a priority after stroke, though participants were interested in HIIT. People with stroke reported a lack of understanding of the benefits of HIIT and use of the term \"high intensity\" as barriers to participation. Facilitators included education about safety of HIIT and referral to health professionals. Health professionals reported a lack of knowledge of HIIT prescription parameters and participant motivation as barriers to prescription. Facilitators included education of HIIT prescription and benefits and appropriate screening prior to commencement.</p><p><strong>Conclusions: </strong>People with stroke and health professionals are interested in HIIT after stroke. Increasing knowledge and confidence to participate in, and prescribe HIIT, may increase clinical use.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251317185"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In PD, Non-Invasive Trans-Spinal Magnetic Stimulation Enhances the Effect of Transcranial Magnetic Stimulation on Axial Motor Symptoms: A Double-Blind Randomized Clinical Trial.","authors":"Eman M Khedr, Nourelhoda A Haridy, Mohammad A Korayem, Ahmed Mamdouh Tawfik, Ahmed A Hamed","doi":"10.1177/15459683241300547","DOIUrl":"10.1177/15459683241300547","url":null,"abstract":"<p><strong>Background: </strong>Axial symptoms in Parkinson's disease (PD) often respond poorly to pharmacological treatment. We evaluated whether combining repetitive transcranial magnetic stimulation (rTMS) and repetitive spinal magnetic stimulation (rSMS) is more effective than rTMS alone in improving axial and other motor disabilities in PD.</p><p><strong>Methods: </strong>A total of 42 PD patients with axial symptoms were randomly allocated to 2 experimental intervention groups: Group I received active rTMS + active rSMS (2000 pulses; 20 Hz; 80% resting motor threshold for each motor area \"M1\" + 1500 pulses rSMS 10 Hz, at 50% of maximal stimulator output). Group II received active rTMS + sham rSMS with the same number of pulses. Both groups received 10 sessions (5 consecutive days/week for 2 weeks). Assessments using Freezing of Gait Questionnaire, walking speed, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts II and III, and Parkinson's Disease Questionaire-39 (PDQ-39) were performed at baseline (T0), end of sessions (T1), and 1 month later (T2).</p><p><strong>Results: </strong>At T0, Group II showed higher walking speed. At T1 and T2, Group I demonstrated significantly greater improvements in MDS-UPDRS parts II, III, and sub-items of part III. Group I showed stronger improvement in TUG-T and average fast velocity immediately post-intervention, but this effect diminished after 1 month. PDQ-39 scores for leisure activity and walking problems were significantly higher in group I.</p><p><strong>Conclusions: </strong>These findings indicate that combining rTMS and rSMS for 10 sessions is more effective than rTMS alone in managing PD's motor and axial symptoms. The effect size of the outcome is large enough to be of significance in clinical practice.</p><p><strong>Trial registration: </strong>The study was registered prospectively on 26/12/2021 at the clinicaltrial.gov website with the registration ID: NCT05271513, https://clinicaltrials.gov/study/NCT05271513.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"126-137"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}