Neurorehabilitation and neural repair最新文献

{"title":"The Weak Relationship Between Ankle Proprioception and Gait Speed After Stroke: A Robotic Assessment Study.","authors":"Christopher A Johnson, Piyashi Biswas, Rubi Tapia, Jill See, Lucy Dodakian, Vicky Chan, Po T Wang, Zoran Nenadic, An H Do, David J Reinkensmeyer","doi":"10.1177/15459683251369497","DOIUrl":"10.1177/15459683251369497","url":null,"abstract":"<p><strong>Background: </strong>After stroke, ankle proprioceptive deficits are common and do not typically correlate with ankle weakness. Some studies report that these deficits correlate with gait function, supporting the importance of somatosensory input for gait control. Others have not found a relationship, possibly due to use of coarse proprioception measures. Robotic assessments of proprioception offer improved consistency and sensitivity.</p><p><strong>Objective: </strong>To establish relationships between ankle proprioception, gait function, and ankle motor in stroke survivors.</p><p><strong>Methods: </strong>We studied 39 individuals in the chronic phase of stroke using 2 robotic tests, Crisscross and Joint Position Reproduction (JPR), to quantify ankle proprioception. We examined associations of these measures with gait speed (10-meter walk test) and gait endurance (6-minute walk test). We also analyzed correlations with lower extremity motor impairment, including robotic measures of ankle strength (MVC) and active range of motion (AROM), and the lower extremity Fugl-Meyer exam (LEFM).</p><p><strong>Results: </strong>Impaired ankle proprioception was present in 87% of participants. Crisscross error weakly correlated with the 10mWT gait speed (ρ = -0.20, <i>P</i> = 0.23) and 6MWT distance (ρ = -0.28, <i>P</i> = .089). JPR error weakly correlated with 10mWT gait speed (ρ = -0.29, <i>P</i> = .092) and significantly correlated with 6MWT distance (ρ = -0.34, <i>P</i> = .04). No significant correlations were observed between ankle proprioceptive error and MVC, AROM, or LEFM (<i>P</i> > 0.2).</p><p><strong>Conclusion: </strong>These results confirm the presence of a weak relationship between ankle proprioception and gait after stroke that is independent of several common measures of motor impairment.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251369497"},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficient Muscle Coordination Patterns of Reactive Stepping Responses in People With Chronic Stroke.","authors":"Wouter Staring, Lotte van de Venis, Sarah Zandvliet, Digna de Kam, Teodoro Solis-Escalante, Alexander Geurts, Vivian Weerdesteyn","doi":"10.1177/15459683251369502","DOIUrl":"https://doi.org/10.1177/15459683251369502","url":null,"abstract":"<p><strong>Background: </strong>People with stroke often have persistent balance impairments that have a profound impact on mobility and daily life independence. Several studies have been conducted to identify stroke-related deficits in neuromuscular responses to balance perturbations. Yet, the majority of these studies involved low-intensity, non-stepping perturbations, whereas falling typically occurs at high-intensity perturbations where stepping is a key saving strategy.</p><p><strong>Objective: </strong>We aimed to identify deficits in muscle coordination patterns of reactive stepping in people with supratentorial stroke (PwS).</p><p><strong>Methods: </strong>We included 32 PwS, who performed multidirectional stepping responses with their paretic and non-paretic leg. We determined step quality, and performed muscle synergy analysis to characterize stance- and swing-leg muscle coordination patterns.</p><p><strong>Results: </strong>We observed smaller leg angles in PwS in lateral, posterolateral and posterior directions, particularly with the paretic leg. Muscle synergy analysis yielded a set of 5 synergies in both groups for the swing VAF_Paretic = 0.84 ± 0.02, VAF_Non-Paretic = 0.84 ± 0.02) and stance leg VAF_Paretic = 0.85 ± 0.02, VAF_Non-Paretic = 0.84 ± 0.02). Three synergies were less frequently represented during paretic step execution. In addition, for the synergy with prominent gluteus medius involvement, underrepresentation was associated with lower Fugl-Meyer lower-extremity scores.</p><p><strong>Conclusions: </strong>The finding of deficient synergy structure and activation during reactive stepping complements and extends insights into balance related impairments after stroke. As the key next step, the methodology presented here allows identifying whether training-induced gains in reactive step quality are related to optimization of pre-existing coordination patterns, or whether some degree of behavioral restitution (i.e., return to \"normal\" coordination patterns) may still be possible.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251369502"},"PeriodicalIF":3.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure Changes in the Cervical Spinal Cord and Brain in Children With Complete Thoracolumbar Spinal Cord Injury.","authors":"Qunya Qi, Ling Wang, Beining Yang, Yulong Jia, Yu Wang, Haotian Xin, Weimin Zheng, Xin Chen, Qian Chen, Fang Li, Jubao Du, Jie Lu, Nan Chen","doi":"10.1177/15459683251369490","DOIUrl":"https://doi.org/10.1177/15459683251369490","url":null,"abstract":"<p><strong>Objective: </strong>Investigating structural changes in the cervical spinal cord and brain in children with complete thoracolumbar spinal cord injury (TLSCI) and their correlation with clinical function may provide objective imaging indicators for functional evaluation.</p><p><strong>Methods: </strong>Twenty-one children with complete TLSCI and twenty-one typically developing (TD) children were enrolled in this study. All participants underwent whole-brain and upper cervical spinal cord sagittal 3D T1-weighted and whole-brain axial diffusion tensor imaging scans using a 3.0T MRI scanner. Utilizing the Spinal Cord Toolbox, cervical spinal cord morphological parameters were obtained. Brain structure changes were analyzed with voxel-based morphometry (VBM) and voxel-based analysis (VBA).</p><p><strong>Results: </strong>Compared to TD children, children with TLSCI showed significant reductions in the CSA (<i>P</i> = .011) and APW (<i>P</i> = .002) at the C2/3 level, as well as significant atrophy in the gray matter volume (GMV) of the left thalamus (<i>P</i> = .026), and bilateral paracentral lobule (PCL, <i>P</i> = .002). There was a significant positive correlation (r = 0.540, <i>P</i> = .017) between GMV of bilateral PCL and sensory scores. The VBA results showed a significant increase in fractional anisotropy values in the right posterior limb of the internal capsule, posterior thalamic radiation, and superior longitudinal fasciculus (SLF, <i>P</i> = .045), the mean diffusivity value of the right SLF was significantly decreased (<i>P</i> = .049) in children with TLSCI.</p><p><strong>Conclusions: </strong>In children with complete TLSCI, specific structural changes in the cervical spinal cord and brain were observed. A significant correlation between GMV of bilateral PCL and sensory scores may provide imaging biomarkers for assessing neurologic function and therapeutic efficacy (Ethics No: [2020] 003).</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251369490"},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Cueing With Laser Shoes Does Not Improve Walking in Parkinson's Disease: Evidence Across Disease Severity and Freezing Status.","authors":"Samuel Stuart, Rodrigo Vitorio, Lisa Graham, Julia Das, Richard Walker, Claire McDonald, Martina Mancini, Rosie Morris","doi":"10.1177/15459683251369477","DOIUrl":"https://doi.org/10.1177/15459683251369477","url":null,"abstract":"<p><strong>Background: </strong>Gait impairment in Parkinson's disease (PD) occurs early and pharmaceutical interventions do not fully restore this function. Visual cueing has been shown to improve gait and alleviate freezing of gait (FOG) in PD. Technological development of digital laser shoe visual cues now allows for visual cues to be used continuously when walking. This study aimed to investigate the effects of laser shoe visual cueing on gait in people with PD across different disease severity (i.e., Hoehn & Yahr [H&Y] stages I-III) and FOG status.</p><p><strong>Methods: </strong>Eighty people with PD (H&YI = 20, H&YII = 30 [15 FOG, 15 noFOG], H&YIII = 30 [15 FOG, 15 noFOG]) walked a 10 m straight path (back and forth) self-paced for 80 seconds without and then with laser shoe cues (participants were allowed 1-2 walks to familiarize with the cues). Inertial sensors were used to measure gait metrics. Laser cue line was set to usual step length for individuals based on their usual walk data from the inertial sensors.</p><p><strong>Results: </strong>Laser shoe cueing did not improve gait in PD regardless of disease severity or FOG status. Across all groups, participants decreased gait speed (<i>P</i> < .001), cadence (<i>P</i> < .001), arm range of motion (<i>P</i> < .005), and increased stride time, double support time (<i>P</i> < .001), elevation at midswing (<i>P</i> < .001), and gait variability (<i>P</i> < .001) with the laser shoes compared to usual walking.</p><p><strong>Conclusion: </strong>Digital laser shoe visual cues do not improve gait in people with PD across disease severity or FOG status. Further investigation is required to examine different cue settings or exposure periods.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251369477"},"PeriodicalIF":3.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Rehabilitation in Multiple Sclerosis: Randomized Controlled Trial and Cost-Effectiveness Analysis Comparing Customized With Booklet Based Vestibular Rehabilitation for Vestibulopathy.","authors":"Jonathan Marsden, Rachel Dennett, Angela Gibbon, Rachel Knight Lozano, Jennifer A Freeman, Doris-Eva Bamiou, Chris Harris, Annie Hawton, Elizabeth Goodwin, Siobhan Creanor, Lexy Sorrell, Joanne Hoskings, Marousa Pavlou","doi":"10.1177/15459683251345444","DOIUrl":"10.1177/15459683251345444","url":null,"abstract":"<p><strong>Background: </strong>Vestibular dysfunction occurs in 30% to 70% of cases with multiple sclerosis (MS).</p><p><strong>Objective: </strong>To compare the clinical and cost-effectiveness of a customized vestibular rehabilitation (VR) program with a generic booklet-based VR intervention in people with MS with clinical signs of vestibulopathy.</p><p><strong>Methods: </strong>People with MS and symptoms of vertigo and/or imbalance were screened for vestibulopathy (n = 73). Seventy recruited participants were randomly allocated to a 12-week generic booklet-based home program with telephone support (n = 35) or a 12-week customized VR program (n = 35, 12 face-to-face sessions and a home exercise program). The primary clinical outcome was the Dizziness Handicap Inventory (DHI) at 26 weeks post-randomization. The primary economic endpoint was quality-adjusted life-years (QALYs). Secondary outcomes included vertigo severity, balance, gait, and perceived impact of physical symptoms in MS.</p><p><strong>Results: </strong>There was no significant between-group difference in the DHI: mean reduction -1.76 (95% confidence interval -10.02, 6.50) at week 26 in favor of the customized group (<i>P</i> = .670). There were significant differences in favor of the customized group for vertigo symptom score, balance confidence, walking, and perceived impact of MS. Primary cost-effectiveness analysis showed customized VR to be less costly and more effective. However, removal of 2 cost outliers in sensitivity analysis resulted in a mean cost-per-QALY of £30 147. Customized VR was also cost-effective from a societal perspective.</p><p><strong>Discussion: </strong>Impairment level improvements did not translate into functional improvements as measured by the DHI perhaps reflecting that vestibular dysfunction is one of several impairments in MS. The findings indicate the potential cost-effectiveness of the customized program.</p><p><strong>Clinical trial registration: </strong>ISRCTN27374299.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"687-700"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Joint Individuation and Abnormal Synergy Post Stroke in Upper Limb Movements.","authors":"Kyung Koh, Giovanni Oppizzi, Raziyeh Baghi, Glenn Joseph Kehs, Li-Qun Zhang","doi":"10.1177/15459683251340914","DOIUrl":"10.1177/15459683251340914","url":null,"abstract":"<p><p>BackgroundStroke often leads to long-term impairments in upper extremity motor function, including muscle weakness, spasticity, and abnormal joint synergies, which hinder independent joint control and daily activities.ObjectiveThis study examined multi-joint motor impairments and characterized abnormal synergy patterns post-stroke using a robotic exoskeleton.MethodsThe exoskeleton independently controlled shoulder, elbow, and wrist joints while measuring responses across all joints during horizontal plane movements. Fifty-three stroke survivors and 24 age-matched controls performed single-joint movements under constrained (fixed joints) and unconstrained (free joints) conditions. Coupled range of torques and range of motion at non-instructed joints were calculated relative to instructed joint movements and summarized in a 3 × 3 matrix.ResultsStroke survivors showed significantly higher coupling torques and motions at non-instructed joints compared to controls, with the greatest impairments in isolating distal movements, particularly in a proximal-to-distal gradient. Abnormal synergy patterns were systematically identified, revealing that stroke survivors exhibited two common patterns for shoulder and elbow tasks, marked by excessive coupling at neighboring joints. For wrist movement tasks, four distinct patterns emerged, involving excessive coupling at both shoulder and elbow joints.ConclusionThese findings demonstrate characteristic impairments in joint individuation and synergy following a stroke, providing a framework to understand motor deficits and guide rehabilitation strategies aimed at restoring joint-specific control.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"715-727"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Wearable Anti-Gravity Supplement to Therapy Does Not Improve Arm Function in Chronic Stroke: A Randomized Pilot Trial.","authors":"Courtney Celian, Partha Ryali, Valentino Wilson, Adith Srivatsa, James L Patton","doi":"10.1177/15459683251338792","DOIUrl":"10.1177/15459683251338792","url":null,"abstract":"<p><p>BackgroundGravity confounds arm movement ability in post-stroke hemiparesis. Reducing its influence allows effective practice leading to recovery. Yet, there is a scarcity of wearable devices suitable for personalized use across diverse therapeutic activities in the clinic.ObjectiveIn this pilot study, we investigated the safety, feasibility, and efficacy of anti-gravity therapy using the ExoNET device in post-stroke participants.MethodsTwenty chronic stroke survivors underwent six, 45-minute occupational therapy sessions while wearing the ExoNET, randomized into either the treatment (ExoNET tuned to gravity-support) or control group (ExoNET tuned to slack condition). Clinical outcomes were evaluated by a blinded-rater at baseline, post, and 6-week follow-up sessions. Kinetic, kinematic, and patient experience outcomes were also assessed.ResultsNo significant effects were found between the treatment and control groups for Action Research Arm Test, Fugl-Meyer Upper Extremity, and Wolf Motor Function Test scores though the treatment group showed an improvement in Box and Blocks scores in the post-intervention session (effect size = 2.1, <i>P</i> = .04). Direct kinetic effects revealed a significant reduction in muscle activity during free exploration with an effect size of (-7.12%, <i>P</i> < .005) but no longitudinal kinetic or kinematic trends. Subject feedback suggested a generally positive perception of the anti-gravity therapy.ConclusionsAnti-gravity therapy with the ExoNET is a safe and feasible treatment for post-stroke rehabilitation. The device provided anti-gravity forces, did not encumber range of motion, and clinical metrics of anti-gravity therapy demonstrated improvements in gross manual dexterity. Further research is required to explore potential benefits in broader clinical metrics.Trial Registration:This study was registered at ClinicalTrials.gov (ID# NCT05180812).</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"728-741"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Doses of Intensive Upper Limb Rehabilitation for Moderate to Severe Impairment in Acute, Subacute Stroke: Phase I Dose Escalation Study.","authors":"Lisa Tedesco Triccas, Peter Hallet, Sofie Cardeynaels, Nick Ward, Nele Bertels, Liselot Thijs, Thierry Lejeune, Ilse Lamers, Annemie Spooren, Peter Feys","doi":"10.1177/15459683251338797","DOIUrl":"10.1177/15459683251338797","url":null,"abstract":"<p><strong>Background: </strong>Optimizing moderate to severe upper limb recovery is likely to require a higher dose of rehabilitation training than is currently delivered, but the feasibility and acceptability of higher dose regimes is unclear in the early-stage post stroke. <b><i>Objective</i>:</b> To determine the maximum time spent on upper limb rehabilitation in people with moderate to severe impairment in acute and early sub-acute stage of stroke, in a phase I dose-escalation study.</p><p><strong>Methods: </strong>Participants were recruited using a 3+3 study design from 2 stroke units and rehabilitation centers in Belgium. Patients received standard care plus escalating doses of upper limb motor training at 4 dose time-on-task levels: 1 (40 minutes), 2 (67 minutes), 3 (100 minutes) and 4 (133 minutes). Treatment was provided for 3 daily sessions, starting with 3 participants at level 1 and if dose was completed based on dose-limiting toxicity criteria, it was escalated to the next level with 3 new participants.</p><p><strong>Results: </strong>Eighteen participants were recruited (median days post-stroke: 7.5 [Q1:5; Q3: 23.3]) with a mean Fugl Meyer Assessment Upper Extremity score of 29.4 (SD: 11.2). The maximum tolerated time-on-task of upper limb rehabilitation was, 100 minutes per day, with an additional 35 minutes of routine upper limb therapy provided as part of standard care. Level of fatigue and rate of perceived exertion were highest at dose level 4, resulting in participants not completing the dose of 133 minutes.</p><p><strong>Conclusions: </strong>Confirmative with existing literature using a different intervention, individuals with moderate to severe impairment in the early-stage of stroke, can tolerate higher doses of upper limb rehabilitation than those typically administered in standard care. These findings support future investigation into phase I/IIa dose-finding clinical trials exploring long-duration, high-intensity upper limb rehabilitation programs in the early post-stroke period.</p><p><strong>Registration: </strong>NCT04973553 (July 22, 2021). https://classic.</p><p><strong>Clinicaltrials: </strong>gov/ct2/show/NCT04973553.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"752-764"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Motor Recovery after Subacute Cerebral Infarction: Role of Corticocerebellar Pathway Integrity.","authors":"Jing Liu, Yi Shan, Bi-Xiao Cui, Shao-Zhen Yan, Lin-Lin Ye, Lei Cao, Miao Zhang, Jie Lu","doi":"10.1177/15459683251351879","DOIUrl":"10.1177/15459683251351879","url":null,"abstract":"<p><p>BackgroundThe cerebellar cortex has gradually become a promising therapeutic target for improving motor recovery post-cerebral infarction, potentially dependent on the structural integrity of motor-related corticocerebellar pathways (CCP). However, the relationship between the imaging markers of motor-related CCP and motor prognosis remains inadequately explored. Utilizing diffusion tensor imaging (DTI), this study aims to longitudinally assess the role of motor-related CCP in predicting motor recovery for both upper and lower extremities following cerebral infarction.MethodsTwenty-nine patients with right middle cerebral artery (MCA) infarction underwent 2 DTI scans 7 to 14 and 30 days after onset, and 29 age-sex matched controls received 1 scan. Fractional anisotropy (FA) values were measured for corticospinal tract (CST) and CCP (cortico-pontocerebellar tract, CPCT; dentate-thalamocortical tract, DTCT; dorsal-spinocerebellar tract, DSCT). Multivariate regression analyses were performed to examine the relationships between DTI parameters and Fugl-Meyer Assessment (FMA).ResultsCompared to the control group, FA and FA asymmetry index (FA-AI) of CST, DTCT, and DSCT on the affected side were significantly reduced. In the linear regression model, the decreased FA-AI of DTCT was a strong predictor for upper FMA (<i>R</i>²_<i>adj</i> = 0.271, <i>P</i> = .022), while the FA-AI of DSCT independently predicted lower limb FMA (<i>R</i>²_<i>adj</i> = 0.400, <i>P</i> = .019).ConclusionsIn patients of MCA infarction, FA-AI of motor-related CCP may be a valuable imaging indicator for predicting motor outcomes. The DTI-assessed structural integrity of the cerebellar ascending fiber tracts (DTCT and DSCT) may correlate with the motor recovery of the upper and lower extremities, respectively.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"765-775"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state Alpha Reactivity Is Reduced in Parkinson's Disease and Associated With Gait Variability.","authors":"Ellen Lirani-Silva, Layla C S Silva, Diego Orcioli-Silva, Victor S Beretta, Lucas G S França, Daniel B Coelho, Rodrigo Vitorio","doi":"10.1177/15459683251347631","DOIUrl":"10.1177/15459683251347631","url":null,"abstract":"<p><p>BackgroundThe extent to which the cholinergic system contributes to gait impairments in Parkinson's disease (PD) remains unclear. Electroencephalography (EEG) alpha reactivity, which refers to change in alpha power over occipital electrodes upon opening the eyes, has been suggested as a marker of cholinergic function. We compared alpha reactivity between people with PD and healthy individuals and explored its potential association with gait measures.MethodsEyes-closed and eyes-open resting-state EEG data were recorded from 20 people with idiopathic PD and 19 healthy individuals with a 64-channel EEG system. Alpha reactivity was calculated as the relative change in alpha power (8-13 Hz) over occipital electrodes from eyes-closed to eyes-open. Gait spatiotemporal measures were obtained with an electronic walkway.ResultsAlpha reactivity was reduced in people with PD compared to healthy individuals (<i>U</i> = 105, <i>P</i> = .017); the rank-biserial correlation of .447 indicated a moderate effect size. When controlling for global cognition (Mini Mental State Examination), the group difference in alpha reactivity was no longer significant. Alpha reactivity associated with measures of gait variability only (ρ = -.437 to -.532).ConclusionsResting-state alpha reactivity is reduced in PD, suggesting impaired cholinergic function. Reduced alpha reactivity was associated with greater gait variability, indicating a role of the cholinergic system in the mechanisms underlying gait variability. Therefore, the cholinergic system may represent a target for treatments aiming to reduce gait variability and alpha reactivity should be further explored as an endpoint for clinical trials.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"742-751"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}