Neurorehabilitation and neural repair最新文献

{"title":"Higher Doses of Intensive Upper Limb Rehabilitation for Moderate to Severe Impairment in Acute, Subacute Stroke: Phase I Dose Escalation Study.","authors":"Lisa Tedesco Triccas, Peter Hallet, Sofie Cardeynaels, Nick Ward, Nele Bertels, Liselot Thijs, Thierry Lejeune, Ilse Lamers, Annemie Spooren, Peter Feys","doi":"10.1177/15459683251338797","DOIUrl":"https://doi.org/10.1177/15459683251338797","url":null,"abstract":"<p><strong>Background: </strong>Optimizing moderate to severe upper limb recovery is likely to require a higher dose of rehabilitation training than is currently delivered, but the feasibility and acceptability of higher dose regimes is unclear in the early-stage post stroke. <b><i>Objective</i>:</b> To determine the maximum time spent on upper limb rehabilitation in people with moderate to severe impairment in acute and early sub-acute stage of stroke, in a phase I dose-escalation study.</p><p><strong>Methods: </strong>Participants were recruited using a 3+3 study design from 2 stroke units and rehabilitation centers in Belgium. Patients received standard care plus escalating doses of upper limb motor training at 4 dose time-on-task levels: 1 (40 minutes), 2 (67 minutes), 3 (100 minutes) and 4 (133 minutes). Treatment was provided for 3 daily sessions, starting with 3 participants at level 1 and if dose was completed based on dose-limiting toxicity criteria, it was escalated to the next level with 3 new participants.</p><p><strong>Results: </strong>Eighteen participants were recruited (median days post-stroke: 7.5 [Q1:5; Q3: 23.3]) with a mean Fugl Meyer Assessment Upper Extremity score of 29.4 (SD: 11.2). The maximum tolerated time-on-task of upper limb rehabilitation was, 100 minutes per day, with an additional 35 minutes of routine upper limb therapy provided as part of standard care. Level of fatigue and rate of perceived exertion were highest at dose level 4, resulting in participants not completing the dose of 133 minutes.</p><p><strong>Conclusions: </strong>Confirmative with existing literature using a different intervention, individuals with moderate to severe impairment in the early-stage of stroke, can tolerate higher doses of upper limb rehabilitation than those typically administered in standard care. These findings support future investigation into phase I/IIa dose-finding clinical trials exploring long-duration, high-intensity upper limb rehabilitation programs in the early post-stroke period.</p><p><strong>Registration: </strong>NCT04973553 (July 22, 2021). https://classic.</p><p><strong>Clinicaltrials: </strong>gov/ct2/show/NCT04973553.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251338797"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Motor Recovery after Subacute Cerebral Infarction: Role of Corticocerebellar Pathway Integrity.","authors":"Jing Liu, Yi Shan, Bi-Xiao Cui, Shao-Zhen Yan, Lin-Lin Ye, Lei Cao, Miao Zhang, Jie Lu","doi":"10.1177/15459683251351879","DOIUrl":"https://doi.org/10.1177/15459683251351879","url":null,"abstract":"<p><p>BackgroundThe cerebellar cortex has gradually become a promising therapeutic target for improving motor recovery post-cerebral infarction, potentially dependent on the structural integrity of motor-related corticocerebellar pathways (CCP). However, the relationship between the imaging markers of motor-related CCP and motor prognosis remains inadequately explored. Utilizing diffusion tensor imaging (DTI), this study aims to longitudinally assess the role of motor-related CCP in predicting motor recovery for both upper and lower extremities following cerebral infarction.MethodsTwenty-nine patients with right middle cerebral artery (MCA) infarction underwent 2 DTI scans 7 to 14 and 30 days after onset, and 29 age-sex matched controls received 1 scan. Fractional anisotropy (FA) values were measured for corticospinal tract (CST) and CCP (cortico-pontocerebellar tract, CPCT; dentate-thalamocortical tract, DTCT; dorsal-spinocerebellar tract, DSCT). Multivariate regression analyses were performed to examine the relationships between DTI parameters and Fugl-Meyer Assessment (FMA).ResultsCompared to the control group, FA and FA asymmetry index (FA-AI) of CST, DTCT, and DSCT on the affected side were significantly reduced. In the linear regression model, the decreased FA-AI of DTCT was a strong predictor for upper FMA (<i>R</i>²_<i>adj</i> = 0.271, <i>P</i> = .022), while the FA-AI of DSCT independently predicted lower limb FMA (<i>R</i>²_<i>adj</i> = 0.400, <i>P</i> = .019).ConclusionsIn patients of MCA infarction, FA-AI of motor-related CCP may be a valuable imaging indicator for predicting motor outcomes. The DTI-assessed structural integrity of the cerebellar ascending fiber tracts (DTCT and DSCT) may correlate with the motor recovery of the upper and lower extremities, respectively.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251351879"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state Alpha Reactivity Is Reduced in Parkinson's Disease and Associated With Gait Variability.","authors":"Ellen Lirani-Silva, Layla C S Silva, Diego Orcioli-Silva, Victor S Beretta, Lucas G S França, Daniel B Coelho, Rodrigo Vitorio","doi":"10.1177/15459683251347631","DOIUrl":"https://doi.org/10.1177/15459683251347631","url":null,"abstract":"<p><p>BackgroundThe extent to which the cholinergic system contributes to gait impairments in Parkinson's disease (PD) remains unclear. Electroencephalography (EEG) alpha reactivity, which refers to change in alpha power over occipital electrodes upon opening the eyes, has been suggested as a marker of cholinergic function. We compared alpha reactivity between people with PD and healthy individuals and explored its potential association with gait measures.MethodsEyes-closed and eyes-open resting-state EEG data were recorded from 20 people with idiopathic PD and 19 healthy individuals with a 64-channel EEG system. Alpha reactivity was calculated as the relative change in alpha power (8-13 Hz) over occipital electrodes from eyes-closed to eyes-open. Gait spatiotemporal measures were obtained with an electronic walkway.ResultsAlpha reactivity was reduced in people with PD compared to healthy individuals (<i>U</i> = 105, <i>P</i> = .017); the rank-biserial correlation of .447 indicated a moderate effect size. When controlling for global cognition (Mini Mental State Examination), the group difference in alpha reactivity was no longer significant. Alpha reactivity associated with measures of gait variability only (ρ = -.437 to -.532).ConclusionsResting-state alpha reactivity is reduced in PD, suggesting impaired cholinergic function. Reduced alpha reactivity was associated with greater gait variability, indicating a role of the cholinergic system in the mechanisms underlying gait variability. Therefore, the cholinergic system may represent a target for treatments aiming to reduce gait variability and alpha reactivity should be further explored as an endpoint for clinical trials.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251347631"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Joint Individuation and Abnormal Synergy Post Stroke in Upper Limb Movements.","authors":"Kyung Koh, Giovanni Oppizzi, Raziyeh Baghi, Glenn Joseph Kehs, Li-Qun Zhang","doi":"10.1177/15459683251340914","DOIUrl":"10.1177/15459683251340914","url":null,"abstract":"<p><p>BackgroundStroke often leads to long-term impairments in upper extremity motor function, including muscle weakness, spasticity, and abnormal joint synergies, which hinder independent joint control and daily activities.ObjectiveThis study examined multi-joint motor impairments and characterized abnormal synergy patterns post-stroke using a robotic exoskeleton.MethodsThe exoskeleton independently controlled shoulder, elbow, and wrist joints while measuring responses across all joints during horizontal plane movements. Fifty-three stroke survivors and 24 age-matched controls performed single-joint movements under constrained (fixed joints) and unconstrained (free joints) conditions. Coupled range of torques and range of motion at non-instructed joints were calculated relative to instructed joint movements and summarized in a 3 × 3 matrix.ResultsStroke survivors showed significantly higher coupling torques and motions at non-instructed joints compared to controls, with the greatest impairments in isolating distal movements, particularly in a proximal-to-distal gradient. Abnormal synergy patterns were systematically identified, revealing that stroke survivors exhibited two common patterns for shoulder and elbow tasks, marked by excessive coupling at neighboring joints. For wrist movement tasks, four distinct patterns emerged, involving excessive coupling at both shoulder and elbow joints.ConclusionThese findings demonstrate characteristic impairments in joint individuation and synergy following a stroke, providing a framework to understand motor deficits and guide rehabilitation strategies aimed at restoring joint-specific control.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251340914"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musical Hallucinosis: Auditory Illusions After Hearing Loss and Cochlear Implantation.","authors":"Bruce H Dobkin","doi":"10.1177/15459683251348171","DOIUrl":"10.1177/15459683251348171","url":null,"abstract":"<p><p>BackgroundPhantom auditory percepts are especially prevalent in healthy persons with hearing loss. No first-person description of the not uncommon illusion called musical hallucinosis (MH) has been published in relation to possible neural mechanisms for its occurrence.ObjectivesThe author presents his personal experience following implantation of a unilateral cochlear neuroprosthesis to try to compensate for progressive sensorineural hearing loss.ResultsThe MH included abrupt onset of persistent, robust singing of the Star-Spangled Banner, then other familiar songs and nursery rhymes by a men's choir without accompanying instrumentals, followed months later by continuous nonsense lyrics sung to a simpler stereotyped tune. The onset was associated with deafness as a complication of electrode placement within the cochlea, the early sizzling, synthetic, monotonal auditory sounds heard using the cochlear implant, and a burst of cacophonous tinnitus following a higher volume adjustment to the device.ConclusionsSeveral physiological alterations, including deafferentation-induced spontaneous auditory pathway activity that triggers higher auditory cortical areas to place the ambiguous inputs within the individual's prior experience of sound patterns, may help explain the evolution of MH and its persistence as a type of maladaptive neuroplasticity.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251348171"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Wearable Anti-Gravity Supplement to Therapy Does Not Improve Arm Function in Chronic Stroke: A Randomized Pilot Trial.","authors":"Courtney Celian, Partha Ryali, Valentino Wilson, Adith Srivatsa, James L Patton","doi":"10.1177/15459683251338792","DOIUrl":"10.1177/15459683251338792","url":null,"abstract":"<p><p>BackgroundGravity confounds arm movement ability in post-stroke hemiparesis. Reducing its influence allows effective practice leading to recovery. Yet, there is a scarcity of wearable devices suitable for personalized use across diverse therapeutic activities in the clinic.ObjectiveIn this pilot study, we investigated the safety, feasibility, and efficacy of anti-gravity therapy using the ExoNET device in post-stroke participants.MethodsTwenty chronic stroke survivors underwent six, 45-minute occupational therapy sessions while wearing the ExoNET, randomized into either the treatment (ExoNET tuned to gravity-support) or control group (ExoNET tuned to slack condition). Clinical outcomes were evaluated by a blinded-rater at baseline, post, and 6-week follow-up sessions. Kinetic, kinematic, and patient experience outcomes were also assessed.ResultsNo significant effects were found between the treatment and control groups for Action Research Arm Test, Fugl-Meyer Upper Extremity, and Wolf Motor Function Test scores though the treatment group showed an improvement in Box and Blocks scores in the post-intervention session (effect size = 2.1, <i>P</i> = .04). Direct kinetic effects revealed a significant reduction in muscle activity during free exploration with an effect size of (-7.12%, <i>P</i> < .005) but no longitudinal kinetic or kinematic trends. Subject feedback suggested a generally positive perception of the anti-gravity therapy.ConclusionsAnti-gravity therapy with the ExoNET is a safe and feasible treatment for post-stroke rehabilitation. The device provided anti-gravity forces, did not encumber range of motion, and clinical metrics of anti-gravity therapy demonstrated improvements in gross manual dexterity. Further research is required to explore potential benefits in broader clinical metrics.Trial Registration:This study was registered at ClinicalTrials.gov (ID# NCT05180812).</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251338792"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion Tensor Imaging Findings in Cerebral Sensorimotor Areas in Patients After Spinal Cord Injury Correlate With Neurophysiological Deficits.","authors":"Anna Zimny, Przemysław Podgórski, Weronika Machaj, Wojciech Fortuna, Juliusz Huber, Barbara Bobek-Billewicz, Paweł Tabakow","doi":"10.1177/15459683251345434","DOIUrl":"10.1177/15459683251345434","url":null,"abstract":"<p><p>ObjectivesAssessment of sensorimotor cortex and tracts degeneration using novel diffusion tensor imaging (DTI) templates in patients with chronic spinal cord injury (SCI) and its correlation with clinical and neurophysiological findings.MethodsSex and age-matched 29 patients with chronic SCI (paraplegic: p-SCI; tetraplegic: t-SCI) and 29 healthy controls underwent neurophysiological assessment including motor evoked potentials (MEP). DTI was performed on 3 T magnetic resonance imaging scanner and postprocessed using Human Motor Area and Sensorimotor Area Tract Templates. DTI parameters were compared using analysis of covariance with post hoc Scheffé and Bonferroni corrections. Spearman's rank test was used for correlations with <i>P</i> < .05 considered significant.ResultsCompared to controls, all SCI patients showed significantly lower fractional anisotropy (FA) in several tracts (primary motor [M1], somatosensory [S1], pre-supplementary motor area [preSMA], and dorsal premotor [PMd]) and cortices (M1, pre-SMA, and S1). There were no differences in DTI parameters between p-SCI and t-SCI or p-SCI and controls. Compared to controls, t-SCI showed significantly decreased FA within M1 and S1 tracts. In t-SCI higher motor scores were associated with higher FA from ventral premotor area (PMv) tracts and cortex; higher sensory scores were associated with higher FA from S1 tracts. Positive correlations were found between MEP amplitudes from rectus femoris muscles and FA for M1, PMd, PMv, pre-SMA, SMA tracts, and PMv cortex.ConclusionsDTI shows remote degeneration of sensorimotor cortex and supraspinal tracts in SCI correlating with several clinical motor and sensory scores, and MEP parameters. DTI metrics have the potential to become biomarkers of remote degeneration.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251345434"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Rehabilitation in Multiple Sclerosis: Randomized Controlled Trial and Cost-Effectiveness Analysis Comparing Customized With Booklet Based Vestibular Rehabilitation for Vestibulopathy.","authors":"Jonathan Marsden, Rachel Dennett, Angela Gibbon, Rachel Knight Lozano, Jennifer A Freeman, Doris-Eva Bamiou, Chris Harris, Annie Hawton, Elizabeth Goodwin, Siobhan Creanor, Lexy Sorrell, Joanne Hoskings, Marousa Pavlou","doi":"10.1177/15459683251345444","DOIUrl":"https://doi.org/10.1177/15459683251345444","url":null,"abstract":"<p><strong>Background: </strong>Vestibular dysfunction occurs in 30% to 70% of cases with multiple sclerosis (MS).</p><p><strong>Objective: </strong>To compare the clinical and cost-effectiveness of a customized vestibular rehabilitation (VR) program with a generic booklet-based VR intervention in people with MS with clinical signs of vestibulopathy.</p><p><strong>Methods: </strong>People with MS and symptoms of vertigo and/or imbalance were screened for vestibulopathy (n = 73). Seventy recruited participants were randomly allocated to a 12-week generic booklet-based home program with telephone support (n = 35) or a 12-week customized VR program (n = 35, 12 face-to-face sessions and a home exercise program). The primary clinical outcome was the Dizziness Handicap Inventory (DHI) at 26 weeks post-randomization. The primary economic endpoint was quality-adjusted life-years (QALYs). Secondary outcomes included vertigo severity, balance, gait, and perceived impact of physical symptoms in MS.</p><p><strong>Results: </strong>There was no significant between-group difference in the DHI: mean reduction -1.76 (95% confidence interval -10.02, 6.50) at week 26 in favor of the customized group (<i>P</i> = .670). There were significant differences in favor of the customized group for vertigo symptom score, balance confidence, walking, and perceived impact of MS. Primary cost-effectiveness analysis showed customized VR to be less costly and more effective. However, removal of 2 cost outliers in sensitivity analysis resulted in a mean cost-per-QALY of £30 147. Customized VR was also cost-effective from a societal perspective.</p><p><strong>Discussion: </strong>Impairment level improvements did not translate into functional improvements as measured by the DHI perhaps reflecting that vestibular dysfunction is one of several impairments in MS. The findings indicate the potential cost-effectiveness of the customized program.</p><p><strong>Clinical trial registration: </strong>ISRCTN27374299.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251345444"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Acute and Chronic Effects of Cardiovascular Exercise on Brain-Derived Neurotrophic Factor in Early Subacute Stroke.","authors":"Bernat De Las Heras, Lynden Rodrigues, Jacopo Cristini, Eric Yu, Ziv Gan-Or, Nathalie Arbour, Alexander Thiel, Ada Tang, Joyce Fung, Janice J Eng, Marc Roig","doi":"10.1177/15459683251342150","DOIUrl":"https://doi.org/10.1177/15459683251342150","url":null,"abstract":"<p><p>BackgroundFollowing stroke, a growth-promoting response resulting in heightened neuroplasticity occurs during the early subacute stages of recovery, a period during which the brain may be more responsive to therapeutical interventions. Given its central role in regulating neuroplastic processes and brain repair in animal models, brain-derived neurotrophic factor (BDNF) has been targeted as a potential biomarker for stroke recovery in humans, with interventions upregulating BDNF holding therapeutical potential. Cardiovascular exercise (CE) has been recommended for stroke rehabilitation, partly due to its potential to induce neural adaptations, including upregulation of BDNF.ObjectivesTo examine the effects of CE on BDNF in individuals at early subacute stages of recovery.MethodsSeventy-six participants within 3 months of first-ever ischemic stroke were randomly assigned to 8 weeks of either CE plus standard care or standard care alone. To measure the chronic and acute responses to exercise in serum BDNF levels, blood samples were collected before and immediately after a graded exercise test conducted at baseline, 4, and 8 weeks. The potential role of the BDNF Val66Met polymorphism in modulating the BDNF response was also explored. Data were analyzed following an intention-to-treat approach.ResultsDespite clinically important increases in cardiorespiratory fitness, CE did not induce significant chronic or acute changes in serum BDNF. Furthermore, the response to CE was not associated with changes in cardiorespiratory fitness and clinical outcomes or was modulated by Val66Met.ConclusionsThese findings indicate that CE has a limited capacity to upregulate circulating BDNF in subacute stages of stroke recovery.Trial Registration:Exercise and Genotype in Sub-acute Stroke: https://clinicaltrials.gov/study/NCT05076747.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"15459683251342150"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Prosthetic Hand Capabilities Through Biomimicry and Neural Interfaces.","authors":"Mohammad Haghani Dogahe, Mark A Mahan, Miqin Zhang, Somaye Bashiri Aliabadi, Alireza Rouhafza, Sahand Karimzadhagh, Alireza Feizkhah, Abbas Monsef, Mehryar Habibi Roudkenar","doi":"10.1177/15459683251331593","DOIUrl":"10.1177/15459683251331593","url":null,"abstract":"<p><p>Background and ObjectivesProsthetic hand development is undergoing a transformative phase, blending biomimicry and neural interface technologies to redefine functionality and sensory feedback. This article explores the symbiotic relationship between biomimetic design principles and neural interface technology (NIT) in advancing prosthetic hand capabilities.MethodsDrawing inspiration from biological systems, researchers aim to replicate the intricate movements and capabilities of the human hand through innovative prosthetic designs. Central to this endeavor is NIT, facilitating seamless communication between artificial devices and the human nervous system. Recent advances in fabrication methods have propelled brain-computer interfaces, enabling precise control of prosthetic hands by decoding neural activity.ResultsAnatomical complexities of the human hand underscore the importance of understanding biomechanics, neuroanatomy, and control mechanisms for crafting effective prosthetic solutions. Furthermore, achieving the goal of a fully functional cyborg hand necessitates a multidisciplinary approach and biomimetic design to replicate the body's inherent capabilities. By incorporating the expertise of clinicians, tissue engineers, bioengineers, electronic and data scientists, the next generation of the implantable devices is not only anatomically and biomechanically accurate but also offer intuitive control, sensory feedback, and proprioception, thereby pushing the boundaries of current prosthetic technology.ConclusionBy integrating machine learning algorithms, biomechatronic principles, and advanced surgical techniques, prosthetic hands can achieve real-time control while restoring tactile sensation and proprioception. This manuscript contributes novel approaches to prosthetic hand development, with potential implications for enhancing the functionality, durability, and safety of the prosthetic limb.</p>","PeriodicalId":94158,"journal":{"name":"Neurorehabilitation and neural repair","volume":" ","pages":"481-494"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}