Neurological research and practice最新文献

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Intrathecal IgG4 synthesis in IgG4 related spinal hypertrophic pachymeningitis: a case report. 与 IgG4 相关的脊髓肥厚性小脑膜炎的鞘内 IgG4 合成:一份病例报告。
Neurological research and practice Pub Date : 2024-08-29 DOI: 10.1186/s42466-024-00343-2
Lucia K Feldmann, Regina von Manitius, Birgit Julia Grassmann, Judith Rösler, Julia Onken, Christian Meisel, Arend Koch, Eberhard Siebert, Klemens Ruprecht, Andreas Meisel
{"title":"Intrathecal IgG4 synthesis in IgG4 related spinal hypertrophic pachymeningitis: a case report.","authors":"Lucia K Feldmann, Regina von Manitius, Birgit Julia Grassmann, Judith Rösler, Julia Onken, Christian Meisel, Arend Koch, Eberhard Siebert, Klemens Ruprecht, Andreas Meisel","doi":"10.1186/s42466-024-00343-2","DOIUrl":"10.1186/s42466-024-00343-2","url":null,"abstract":"<p><p>Immunoglobulin G4 (IgG4) related hypertrophic pachymeningitis of the spinal cord is a rare condition, characterized by infiltration of the spinal meninges with IgG4-producing plasma cells and subsequent hypertrophic fibrosis. Here, we report on a 65-year-old woman with IgG4 associated hypertrophic spinal pachymeningitis, in whom cerebrospinal fluid (CSF) analysis was a decisive diagnostic tool. Not only could we demonstrate an intrathecal IgG4 production, but also IgG4 positive plasma cells in CSF. Following decompressive surgery, diagnosis of IgG4 associated hypertrophic pachymeningitis was confirmed histologically. Surgery and immunosuppressive therapy with rituximab were associated with clinical improvement. This case highlights CSF analyses as diagnostic tool for detection of IgG4 related hypertrophic pachymeningitis.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
User expectations and experiences of an assistive robotic arm in amyotrophic lateral sclerosis: a multicenter observational study. 肌萎缩性脊髓侧索硬化症患者对辅助机械臂的期望和体验:一项多中心观察研究。
Neurological research and practice Pub Date : 2024-08-23 DOI: 10.1186/s42466-024-00342-3
Susanne Spittel, Thomas Meyer, Ute Weyen, Torsten Grehl, Patrick Weydt, Robert Steinbach, Susanne Petri, Petra Baum, Moritz Metelmann, Anne-Dorte Sperfeld, Dagmar Kettemann, Jenny Norden, Annekathrin Rödiger, Benjamin Ilse, Julian Grosskreutz, Barbara Hildebrandt, Bertram Walter, Christoph Münch, André Maier
{"title":"User expectations and experiences of an assistive robotic arm in amyotrophic lateral sclerosis: a multicenter observational study.","authors":"Susanne Spittel, Thomas Meyer, Ute Weyen, Torsten Grehl, Patrick Weydt, Robert Steinbach, Susanne Petri, Petra Baum, Moritz Metelmann, Anne-Dorte Sperfeld, Dagmar Kettemann, Jenny Norden, Annekathrin Rödiger, Benjamin Ilse, Julian Grosskreutz, Barbara Hildebrandt, Bertram Walter, Christoph Münch, André Maier","doi":"10.1186/s42466-024-00342-3","DOIUrl":"10.1186/s42466-024-00342-3","url":null,"abstract":"<p><strong>Objective: </strong>Robotic arms are innovative assistive devices for ALS patients with progressive motor deficits of arms and hands. The objective was to explore the patients´ expectations towards a robotic arm system and to assess the actual experiences after the provision of the device.</p><p><strong>Methods: </strong>A prospective observational study was conducted at 9 ALS centers in Germany. ALS-related functional deficits were assessed using the ALS-Functional Rating Scale-revised (ALSFRS-R). Motor deficit of the upper limbs was determined using a subscore of three arm-related items of the ALSFRS-R (items 4-6; range 0-12 points). User expectations before provision (expectation group, n = 85) and user experiences after provision (experience group, n = 14) with the device (JACO Assistive Robotic Device, Kinova, Boisbriand, QC, Canada) were assessed.</p><p><strong>Results: </strong>In the total cohort, mean ALSFRS-R subscore for arm function was 1.7 (SD: 2.0, 0-9) demonstrating a severe functional deficit of the upper limbs. In the expectation group (n = 85), the following use cases of the robotic arm have been prioritized: handling objects (89%), close-body movements (88%), pressing buttons (87%), serving drinks (86%), and opening cabinets and doors (85%). In the experience group (n = 14), handling objects (79%), serving drinks (79%), near-body movements (71%), pushing buttons (71%), serving food (64%), and opening doors (64%) were the most frequent used cases. Most patients used the device daily (71.4%, n = 10), and 28.6% (n = 4) several times a week. All patients of the experience group found the device helpful, felt safe while using the device, and were satisfied with its reliability. NPS of the assistive robotic arm revealed 64% \"promoters\" (strong recommendation), 29% \"indifferents\" (uncertain recommendation) and 7% \"detractors\" (no recommendation). Total NPS was + 57 demonstrating strong patient satisfaction.</p><p><strong>Conclusions: </strong>Initiation of procurement with a robotic assistive arm was confined to patients with severe functional deficit of the upper limbs. User experience underlined the wide spectrum of use cases of assistive robotic arms in ALS. The positive user experience together with high satisfaction underscore that robotic arm systems serve as a valuable treatment option in ALS patients with severe motor deficits of the arms.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceived autonomy support in individuals with Parkinson's disease requiring emergency care: a cross-sectional pilot study. 需要紧急护理的帕金森病患者对自主支持的感知:一项横断面试点研究。
Neurological research and practice Pub Date : 2024-08-15 DOI: 10.1186/s42466-024-00340-5
Barend W Florijn, Erik W van Zwet, Ad A Kaptein, Anne A van der Plas
{"title":"Perceived autonomy support in individuals with Parkinson's disease requiring emergency care: a cross-sectional pilot study.","authors":"Barend W Florijn, Erik W van Zwet, Ad A Kaptein, Anne A van der Plas","doi":"10.1186/s42466-024-00340-5","DOIUrl":"10.1186/s42466-024-00340-5","url":null,"abstract":"<p><strong>Background: </strong>Individuals with Parkinson's disease (PD) report a diminished perceived functional autonomy as their condition progresses. For those seeking emergency care, it is unknown whether the patient-physician relationship is instrumental in respecting patient autonomy. This study evaluated patient autonomy ideals in individuals with PD requiring emergency care and the perceived support for autonomy from emergency department physicians.</p><p><strong>Method: </strong>Individuals with PD (n = 36, average age 78.1 years) were surveyed using the Ideal Patient Autonomy questionnaire (IPA) and the Health Care Climate Questionnaire (HCCQ). A multivariable regression analysis assessed whether patients' Hoehn and Yahr stage and IPA questionnaire results predicted HCCQ items.</p><p><strong>Results: </strong>The IPA questionnaire revealed that individuals with PD in need of emergency care emphasize the significance of medical expertise (IPA 'doctor should decide' theme 0.71) in decision-making and their desire to be fully informed about all potential risks (IPA 'obligatory risk information' theme 0.71). The average HCCQ values showed a decreasing trend across Hoehn and Yahr stages 1 to 5: 6.19, 6.03, 5.83, 5.80, and 5.23, respectively. HY scale values also influenced HCCQ items related to the physician's role.</p><p><strong>Conclusion: </strong>In our cohort, individuals with Parkinson's disease tend to rely on medical expertise for decision-making and prioritize complete risk information during emergency care. However, this autonomy support diminishes as functional disability levels increase.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world analysis of brain atrophy in multiple sclerosis patients with an artificial intelligence based software tool. 利用基于人工智能的软件工具对多发性硬化症患者的脑萎缩情况进行真实世界分析。
Neurological research and practice Pub Date : 2024-08-08 DOI: 10.1186/s42466-024-00339-y
Caroline Reinhardt, Klemens Angstwurm, David Freudenstein, De-Hyung Lee, Christina Wendl, Ralf A Linker
{"title":"Real-world analysis of brain atrophy in multiple sclerosis patients with an artificial intelligence based software tool.","authors":"Caroline Reinhardt, Klemens Angstwurm, David Freudenstein, De-Hyung Lee, Christina Wendl, Ralf A Linker","doi":"10.1186/s42466-024-00339-y","DOIUrl":"10.1186/s42466-024-00339-y","url":null,"abstract":"<p><strong>Background: </strong>Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can be quantified by magnetic resonance imaging (MRI) with automated software tools.</p><p><strong>Methods: </strong>In this study, we analyze volumes of various brain regions with the software \"md brain\" based on routine MRI scans of 53 pwMS in a real-world setting. We compare brain volumes of pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years to the brain volumes of pwMS with an EDSS < 3.5 and a disease duration < 10 years as well as with or without immunotherapy.</p><p><strong>Results: </strong>pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years had significantly lower volumes of the total brain, the grey matter and of the frontal, temporal, parietal and occipital lobe regions as compared to pwMS with an EDSS < 3.5 and a disease duration < 10 years. Regional brain volumes were significantly lower in pwMS without immunotherapy.</p><p><strong>Conclusions: </strong>The study showed that higher EDSS, longer disease duration and absence of immunotherapy was associated with lower volumes in a number of brain regions. Further real-world studies may include larger patient cohorts in longitudinal analyses.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11308334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidisciplinary lifestyle interventions for neurological disorders during the Silent phase (MINDS) study: a multi-omics randomized controlled trial protocol. 沉默期神经系统疾病多学科生活方式干预(MINDS)研究:多组学随机对照试验方案。
Neurological research and practice Pub Date : 2024-08-01 DOI: 10.1186/s42466-024-00334-3
Sara Taylor, Seerat Sachdeva, Sandra Darling, Kayela Arrotta, Lisa Gallagher, Alexis Supan, Gabrielle Shipta, Jim Perko, Judi Bar, Joe James, Iris Petschek, Anthony Lioi, Suman Kundu, Lisa Ellison, Lynn M Bekris, Belinda Willard, Naseer Sangwan, Ignacio Mata, Hubert Fernandez, Irene Katzan, Devon Conway, Jagan Pillai, James Leverenz, Robyn M Busch, Darlene Floden, Robert Saper, John Barnard, Andre Machado, Imad Najm, Vineet Punia
{"title":"Multidisciplinary lifestyle interventions for neurological disorders during the Silent phase (MINDS) study: a multi-omics randomized controlled trial protocol.","authors":"Sara Taylor, Seerat Sachdeva, Sandra Darling, Kayela Arrotta, Lisa Gallagher, Alexis Supan, Gabrielle Shipta, Jim Perko, Judi Bar, Joe James, Iris Petschek, Anthony Lioi, Suman Kundu, Lisa Ellison, Lynn M Bekris, Belinda Willard, Naseer Sangwan, Ignacio Mata, Hubert Fernandez, Irene Katzan, Devon Conway, Jagan Pillai, James Leverenz, Robyn M Busch, Darlene Floden, Robert Saper, John Barnard, Andre Machado, Imad Najm, Vineet Punia","doi":"10.1186/s42466-024-00334-3","DOIUrl":"10.1186/s42466-024-00334-3","url":null,"abstract":"<p><strong>Introduction: </strong>Given the prevalence and staggering cost of neurological disorders, there is dire need for effective early detection and intervention tools. Emerging evidence suggests that multidisciplinary lifestyle interventions (MLI) may mitigate the risk and progression of neurological disorders. The objectives of this protocol are (1) to test the impact of MLI on the progression of neurological disorders and (2) to identify multi-omic biomarkers for early stages of neurological disease and the impact of MLIs on these biomarkers.</p><p><strong>Methods and analysis: </strong>We present the Multidisciplinary lifestyle Interventions for Neurological Disorders during the Silent phase (MINDS) protocol, a randomized controlled trial of MLI in neurologically healthy older adults (≥ 50 years old) exhibiting elevated risk for common neurological disorders: stroke, epilepsy, Parkinson's Disease, or Alzheimer's disease and related dementias. Participants will be randomly assigned to intervention (n = 100) or control (n = 100) groups. The intervention group will receive 3 months of weekly 2-hour sessions on diet education, yoga, music therapy, and cognitive skills training. The participants' neurological health and engagement in relevant lifestyle practices will be assessed at regular intervals for 12 months. Neuroimaging and samples for multi-omic analyses will be collected at baseline, and at 3 months and 12 months after enrollment. Primary outcomes will be signs of progression of the neurological disorder risk that qualified them for study enrollment or a clinical diagnosis of the disorder. Secondary and exploratory outcomes will be based on self-reported health and multi-omic data. Data analysis will include between-group and longitudinal within-group analyses.</p><p><strong>Perspectives: </strong>The MINDS protocol and trial aims to clarify the impact of MLI on the progression of neurological disorder risk or diagnosis in older adults and to identify biomarkers that can be used to confirm MLI efficacy. The ability to validate the impact of MLI on neurological disorder progression based on biomarker data allows the identification of individuals most likely to benefit from such therapies in the early stages of neurological disease.</p><p><strong>Trial registration: </strong>The trial is registered on the National Institutes of Health (NIH) ClinicalTrials.gov (NCT05984056) site. It was registered on August 2nd, 2023. The trial has full approval of the Cleveland Clinic Internal Review Board.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular thrombectomy in patients with anterior circulation stroke: an emulated real-world comparison. 前循环中风患者的血管内血栓切除术:模拟真实世界的比较。
Neurological research and practice Pub Date : 2024-07-25 DOI: 10.1186/s42466-024-00331-6
Jochen A Sembill, Maximilian I Sprügel, David Haupenthal, Svenja Kremer, Michael Knott, Iris Mühlen, Bernd Kallmünzer, Joji B Kuramatsu
{"title":"Endovascular thrombectomy in patients with anterior circulation stroke: an emulated real-world comparison.","authors":"Jochen A Sembill, Maximilian I Sprügel, David Haupenthal, Svenja Kremer, Michael Knott, Iris Mühlen, Bernd Kallmünzer, Joji B Kuramatsu","doi":"10.1186/s42466-024-00331-6","DOIUrl":"10.1186/s42466-024-00331-6","url":null,"abstract":"<p><strong>Background: </strong>Endovascular thrombectomy (EVT) has been proven effective in anterior circulation stroke due to large vessel occlusion (LVO). However, translation from randomized clinical trials (RCTs) with highly selected patients to real-world requires confirmation, particularly to identify associations outside of strict selection criteria.</p><p><strong>Aims: </strong>This study aims to compare functional outcomes after EVT in real-world with those reported in RCTs, and to identify associations with functional outcome after EVT outside RCT-criteria.</p><p><strong>Methods: </strong>This study analyzed longitudinal German real-world data from the Stroke Research Consortium in Northern Bavaria (STAMINA) cohort from January, 2015 to June, 2019. We conducted a trial emulation, comparing patients with anterior circulation stroke and LVO meeting selection criteria for RCTs investigating EVT (1) predominantly within 6 hours with those from HERMES meta-analysis, and (2) within 6-24 hours with those from AURORA meta-analysis. We (3) analyzed treatment effects of EVT and association with functional outcome in patients treated outside RCT criteria.</p><p><strong>Results: </strong>Of 598 patients, 281 (47.0%) met RCT-criteria for treatment within 6 hours (hereinafter STAMINA-HERMES), 74 (12.4%) met RCT-criteria for treatment within 6-24 hours (STAMINA-AURORA), and 277 (46.3%) patients received EVT outside RCT-criteria. We observed no difference in rates of functional independence or mortality, comparing STAMINA-HERMES with HERMES meta-analysis (mRS 0-1: n=120/281 [43%] vs. 291/633 [46%], p=0.36; mortality: n=34/281 [12%] vs. 97/633 [15%], p=0.20), and STAMINA-AURORA with AURORA meta-analysis (mRS 0-1: n=26/74 [35%] vs. 122/266 [46%], p=0.10, mortality: n=10/74 [14%] vs. 45/266 [17%], p=0.48). Patients treated outside RCT-criteria had worse outcome (mRS 0-1: n=38/277 [14%], mortality: n=90/277 [32%], both p<0.001); possibly driven by pre-existing functional dependence (n=172/277 [62%]). Compared to matched controls, EVT outside of RCT-criteria was associated with lower mortality (absolute treatment effect: -14%, 95% Confidence Interval [CI] -23 to -5, p<0.01), but not with recovery to functional independence or premorbid functional status (treatment effect: 4%, CI -4 to 11, p=0.34), which was associated with lower NIHSS (Odds ratio [OR] 0.86, CI 0.80-0.92, p<0.001) and age (OR 0.95, CI 0.93-0.98, p=0.002).</p><p><strong>Conclusions: </strong>Translation of EVT outcomes reported in RCTs into real-world is possible, however, almost half of patients did not meet trial criteria. Identification of patients who functionally benefit from frequently performed EVT outside RCT-criteria requires further investigation.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov, NCT04357899.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry. 原发性 M3 闭塞中风的血管内治疗临床实践:德国中风登记分析。
Neurological research and practice Pub Date : 2024-07-18 DOI: 10.1186/s42466-024-00330-7
Niklas M Beckonert, Johannes M Weller, Anna C Alegiani, Tobias Boeckh-Behrens, Milani Deb-Chatterji, Gerhard F Hamann, Lars U Krause, Nils C Lehnen, Louisa Nitsch, Sven Poli, Christian Riedel, Steffen Tiedt, Sarah Zweynert, Gabor C Petzold, Franziska Dorn, Felix J Bode
{"title":"Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry.","authors":"Niklas M Beckonert, Johannes M Weller, Anna C Alegiani, Tobias Boeckh-Behrens, Milani Deb-Chatterji, Gerhard F Hamann, Lars U Krause, Nils C Lehnen, Louisa Nitsch, Sven Poli, Christian Riedel, Steffen Tiedt, Sarah Zweynert, Gabor C Petzold, Franziska Dorn, Felix J Bode","doi":"10.1186/s42466-024-00330-7","DOIUrl":"10.1186/s42466-024-00330-7","url":null,"abstract":"<p><strong>Background: </strong>Endovascular treatment (ET) options for acute stroke due to distal middle cerebral artery occlusions are rapidly evolving, but data on outcome and safety are sparse. We therefore performed an analysis of patients undergoing ET for primary M3 occlusions in routine clinical practice in a nationwide registry.</p><p><strong>Methods: </strong>Patients enrolled between 01/20 and 12/21 in the prospective, multicenter German Stroke Registry-Endovascular Treatment (GSR-ET) were screened for mechanical thrombectomy performed for primary M3 occlusion. We analyzed neurological deficit as measured by the National Institute of Health Stroke Scale (NIHSS), symptomatic intracranial hemorrhage (sICH), thrombectomy technique, successful reperfusion (modified Thrombolysis in Cerebral Infarction [mTICI] score of 2b-3) and functional outcome as measured by the modified Rankin Scale (mRS) at discharge and 90 days.</p><p><strong>Results: </strong>Out of 5574 patients, 11 patients (0.2%, median age 80 years, 54.5% female) underwent ET for primary M3 occlusion. All patients had pre-admission mRS ≤ 1, median NIHSS on admission was 8, and successful reperfusion was achieved in 6/11 patients (54.5%). While no vasospasm, dissection or perforation was reported, symptomatic intracranial hemorrhage occurred in 2 patients (18.2%). Favorable outcome (mRS ≤ 2) was achieved in 6/11 patients (54.5%) at 90-day follow-up.</p><p><strong>Conclusions: </strong>ET for primary M3 occlusions is rarely performed. While technically feasible, the procedure's potential benefits must be carefully weighed against its associated risks, including clinically relevant complications. Caution and further research is needed to optimize patient selection for this intervention.</p><p><strong>Trial registration: </strong>GSR-ET; ClinicalTrials.gov Identifier: NCT03356392; Trial Registration Date: 11/29/2017.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11256396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased body mass index (BMI) associated with late epilepsy onset in patients with temporal encephaloceles: a systematic review and analysis of individual patient data. 颞叶脑疝患者体重指数(BMI)升高与癫痫晚期发病相关:对患者个体数据的系统回顾和分析。
Neurological research and practice Pub Date : 2024-07-11 DOI: 10.1186/s42466-024-00329-0
Panagiota-Eleni Tsalouchidou, Hans-Helge Müller, Ioannis Mintziras, Sascha Strehlau, Wiebke Hahn, Marcus Belke, Felix Zahnert, Gunter Kräling, Katja Menzler, Susanne Knake
{"title":"Increased body mass index (BMI) associated with late epilepsy onset in patients with temporal encephaloceles: a systematic review and analysis of individual patient data.","authors":"Panagiota-Eleni Tsalouchidou, Hans-Helge Müller, Ioannis Mintziras, Sascha Strehlau, Wiebke Hahn, Marcus Belke, Felix Zahnert, Gunter Kräling, Katja Menzler, Susanne Knake","doi":"10.1186/s42466-024-00329-0","DOIUrl":"10.1186/s42466-024-00329-0","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the association of Body Mass Index (BMI) and age of epilepsy onset, in patients with epilepsy associated with temporal encephaloceles (TEs).</p><p><strong>Methods: </strong>A comprehensive PubMed literature review was conducted using the keywords \"temporal encephaloceles\" and \"epilepsy\" for identifying articles for the analysis. Inclusion criteria encompassed all evidence levels reporting patients with TE-related epilepsy and documented BMI. Logistic regression analyses were performed to examine the effect of BMI on predicting epilepsy onset after the 25th year of age. Spearman's correlation assessed the relationship between BMI with epilepsy onset. Finally, the association between BMI and postsurgical outcomes, distinguishing between more favourable outcomes (Engel Class I and II) and less favourable outcomes (Engell Class III and IV) was explored.</p><p><strong>Results: </strong>Of the initially identified 88 articles, nine were included in the analysis, involving 127 patients with TE-related epilepsy and reported BMI. The mean age of epilepsy onset was 24.9 years (SD = 14.8 years), with a mean BMI of 28.0 kg/m<sup>2</sup> (SD = 7.4 kg/m<sup>2</sup>). A significant positive correlation was observed between BMI and age of epilepsy onset (rho = 0.448, p < 0.001). Female patients had higher BMI compared to male patients (30.1 kg/m<sup>2</sup>, SD = 8.7 kg/m<sup>2</sup> and 26.5 kg/m<sup>2</sup>, SD = 5.3 kg/m<sup>2</sup> respectively, p = 0.008). However, the epilepsy onset did not differ significantly between male and female patients (p = 0.26). The bivariate logistic regression showed that patients with increased BMI were more likely to have an epilepsy onset after the 25th year of age, adjusted for the confounder sex (OR = 1.133, 95%-CI [1.060, 1.211], p < 0.001). Finally, a potential trend indicated a higher average BMI among patients with more favourable postsurgical outcomes than less favourable postsurgical outcomes (27.3 kg/m<sup>2</sup>, SD = 7.7 kg/m<sup>2</sup> and 24.8 kg/m<sup>2</sup>, SD = 2.2 kg/m<sup>2</sup> respectively, p = 0.076).</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Use of ketamine in super refractory status epilepticus: a systematic review. 更正:氯胺酮在超级难治性癫痫状态中的应用:系统性综述。
Neurological research and practice Pub Date : 2024-07-09 DOI: 10.1186/s42466-024-00335-2
Aayush Adhikari, Sushil Kumar Yadav, Gaurav Nepal, Roshan Aryal, Pratik Baral, Peter Neupane, Aadesh Paudel, Barsha Pantha, Sulav Acharya, Gentle Sunder Shrestha, Ramesh Khadayat
{"title":"Correction: Use of ketamine in super refractory status epilepticus: a systematic review.","authors":"Aayush Adhikari, Sushil Kumar Yadav, Gaurav Nepal, Roshan Aryal, Pratik Baral, Peter Neupane, Aadesh Paudel, Barsha Pantha, Sulav Acharya, Gentle Sunder Shrestha, Ramesh Khadayat","doi":"10.1186/s42466-024-00335-2","DOIUrl":"10.1186/s42466-024-00335-2","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patients' and caregivers' perception of multidimensional and palliative care in amyotrophic lateral sclerosis - protocol of a German multicentre study. 肌萎缩性脊髓侧索硬化症患者和护理人员对多维护理和姑息护理的看法--德国一项多中心研究的方案。
Neurological research and practice Pub Date : 2024-07-04 DOI: 10.1186/s42466-024-00328-1
Katharina Linse, Constanze Weber, Peter Reilich, Florian Schöberl, Matthias Boentert, Susanne Petri, Annekathrin Rödiger, Andreas Posa, Markus Otto, Joachim Wolf, Daniel Zeller, Robert Brunkhorst, Jan Koch, Andreas Hermann, Julian Großkreutz, Carsten Schröter, Martin Groß, Paul Lingor, Gerrit Machetanz, Luisa Semmler, Johannes Dorst, Dorothée Lulé, Albert Ludolph, Thomas Meyer, André Maier, Moritz Metelmann, Martin Regensburger, Jürgen Winkler, Berthold Schrank, Zacharias Kohl, Tim Hagenacker, Svenja Brakemeier, Ute Weyen, Markus Weiler, Stefan Lorenzl, Sarah Bublitz, Patrick Weydt, Torsten Grehl, Sylvia Kotterba, Hanna-Sophie Lapp, Maren Freigang, Maximilian Vidovic, Elisa Aust, René Günther
{"title":"Patients' and caregivers' perception of multidimensional and palliative care in amyotrophic lateral sclerosis - protocol of a German multicentre study.","authors":"Katharina Linse, Constanze Weber, Peter Reilich, Florian Schöberl, Matthias Boentert, Susanne Petri, Annekathrin Rödiger, Andreas Posa, Markus Otto, Joachim Wolf, Daniel Zeller, Robert Brunkhorst, Jan Koch, Andreas Hermann, Julian Großkreutz, Carsten Schröter, Martin Groß, Paul Lingor, Gerrit Machetanz, Luisa Semmler, Johannes Dorst, Dorothée Lulé, Albert Ludolph, Thomas Meyer, André Maier, Moritz Metelmann, Martin Regensburger, Jürgen Winkler, Berthold Schrank, Zacharias Kohl, Tim Hagenacker, Svenja Brakemeier, Ute Weyen, Markus Weiler, Stefan Lorenzl, Sarah Bublitz, Patrick Weydt, Torsten Grehl, Sylvia Kotterba, Hanna-Sophie Lapp, Maren Freigang, Maximilian Vidovic, Elisa Aust, René Günther","doi":"10.1186/s42466-024-00328-1","DOIUrl":"10.1186/s42466-024-00328-1","url":null,"abstract":"<p><strong>Introduction: </strong>Amyotrophic lateral sclerosis (ALS) is an inevitably fatal condition that leads to a progressive loss of physical functioning, which results in a high psychosocial burden and organizational challenges related to medical care. Multidimensional and multiprofessional care is advised to meet the complex needs of patients and their families. Many healthcare systems, including Germany, may not be able to meet these needs because non-medical services such as psychological support or social counselling are not regularly included in the care of patients with ALS (pwALS). Specialised neuropalliative care is not routinely implemented nor widely available. Caregivers of pwALS are also highly burdened, but there is still a lack of support services for them.</p><p><strong>Methods: </strong>This project aims to assess the perceptions and satisfaction with ALS care in Germany in pwALS and their caregivers. This will be achieved by means of a cross-sectional, multicentre survey. The examination will assess, to which extend the patients' needs in the six domains of physical, psychological, social, spiritual, practical and informational are being met by current care structures. This assessment will be linked to mental well-being, subjective quality of life, attitudes toward life-sustaining measures and physician-assisted suicide, and caregiver burden. The study aims to recruit 500 participants from nationwide ALS centres in order to draw comprehensive conclusions for Germany. A total of 29 centres, mostly acquired via the clinical and scientific German Network for Motor Neuron Diseases (MND-NET), will take part in the project, 25 of which have already started recruitment.</p><p><strong>Perspective: </strong>It is intended to provide data-based starting points on how current practice of care in Germany is perceived pwALS and their caregivers and how it can be improved according to their needs. Planning and initiation of the study has been completed.</p><p><strong>Trial registration: </strong>The study is registered at ClinicalTrails.gov; NCT06418646.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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