Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine最新文献

{"title":"Institutional Variability in Ultrafast Breast MR Imaging: Comparing Compressed Sensing and View Sharing Techniques with Different Patient Populations and Contrast Injection Protocols.","authors":"Maya Honda, Masako Kataoka, Mami Iima, Rie Ota, Aika Okazawa, Yasuhiro Fukushima, Marcel Dominik Nickel, Fumiaki Sato, Norikazu Masuda, Tsutomu Okada, Yuji Nakamoto","doi":"10.2463/mrms.mp.2024-0152","DOIUrl":"https://doi.org/10.2463/mrms.mp.2024-0152","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the institutional variability in ultrafast dynamic contrast-enhanced (UF-DCE) breast MRI using time-resolved angiography with stochastic trajectories (TWIST)-volumetric interpolated breath-hold examination (VIBE) and compressed sensing (CS)-VIBE sequences acquired at 2 different institutions with different patient populations and contrast injection protocols.</p><p><strong>Methods: </strong>UF-DCE MR images of 18 patients from site A acquired using a TWIST-VIBE sequence, and UF-DCE MR images of 18 patients from site B acquired with a CS-VIBE sequence, were retrospectively evaluated and compared. The 2-site patient cohort was matched for patient age, background parenchymal enhancement, malignancy or benignity, and lesion size. Qualitative assessments included noise, blurring, poor fat suppression, aliasing artifact, motion artifact, lesion conspicuity, lesion morphology, time-intensity-curve smoothness, and vessel delineation. For quantitative assessment, the bolus arrival time was evaluated for each lesion, and its diagnostic performance in discriminating between benign and malignant lesions was examined using receiver operating characteristics analysis.</p><p><strong>Results: </strong>Thirteen malignant and five benign lesions were included from each site. Qualitative evaluation revealed that poor fat suppression and aliasing artifacts were visible in images from site A with TWIST-VIBE (P = 0.004 and P < 0.001), whereas motion artifacts were present in images from site B with CS-VIBE (P = 0.04). Lesion morphology assessments (P < 0.001) and vessel delineation (P < 0.001) were superior for images from site B with CS-VIBE. Bolus arrival time was significantly longer with TWIST-VIBE than with CS-VIBE, for both benign and malignant lesions (P < 0.001). The area under the receiver operating characteristics curve was 0.55 for site A and 0.69 for site B (P = 0.39).</p><p><strong>Conclusion: </strong>Both acquisitions allowed evaluation of breast lesions with good lesion conspicuity and time-intensity-curve smoothness, whereas CS-VIBE was superior to TWIST-VIBE for morphological evaluation of breast lesions and depiction of blood vessels in the breast. Injection rate appears to have a significant impact on semi-quantitative parameters derived from UF-DCE MRI.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Clinical Implementation of Magnetic Resonance Imaging for Placental Function.","authors":"Yuki Himoto, Koji Fujimoto, Yoshitsugu Chigusa, Atsushi Yoshida, Sachiko Minamiguchi, Aki Kido, Yuji Nakamoto","doi":"10.2463/mrms.rev.2024-0154","DOIUrl":"https://doi.org/10.2463/mrms.rev.2024-0154","url":null,"abstract":"<p><p>Placental insufficiency is a critical condition in perinatal medicine, clinically manifesting as fetal growth restriction or preeclampsia. In addition to ultrasound and Doppler velocimetry, MRI has been assessed intensively for its potential to evaluate placental function directly. Several methods investigated to date include anthropometry, visual assessments using T2-weighted images, and quantitative evaluations based on T2 values, hypoxia indicators (T2* values and blood oxygenation level-dependent imaging), and perfusion metrics (intravoxel incoherent motion and arterial spin labeling). Anthropometry and visual assessments are easily implemented clinically because they require no specific technique or post-processing. By contrast, quantitative approaches provide objective numerical indicators, making them promising imaging biomarkers. Despite their potential, translating these methods into clinical practice presents challenges, especially for quantitative techniques, because of limited availability, lack of standardization, and inadequate clinician awareness. This review was conducted to overview the clinical aspects of placental insufficiency, summarize the anthropometry, visual assessments, and quantitative methods reported, and highlight the latest advancements. It also presents discussion of related challenges and future prospects for clinical implementation.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Design of a Thermal Applicator for Brain Hyperthermia Controlled by Capacitor Positioning in Loop Coils.","authors":"Daniel Hernandez, Taewoo Nam, Eunwoo Lee, Yeunchul Ryu, Jun-Young Chung, Kyoung-Nam Kim","doi":"10.2463/mrms.mp.2024-0086","DOIUrl":"https://doi.org/10.2463/mrms.mp.2024-0086","url":null,"abstract":"<p><strong>Purpose: </strong>Hyperthermia is a treatment that applies heat to damage or kill cancer cells and can be also used for drug deliveries. It is important to apply the heat into the specific area in order to target the cancer tissue and avoid damaging healthy tissue. For this reason, the development of heat applicators that have the capability to deliver the heat to the target area is vital. In this study, we present an optimization of an array coil for brain hyperthermia that can be used in combination with MRI, such that the heat can be delivered to the cancer area.</p><p><strong>Methods: </strong>The array coils were based on optimizing loop coils by varying the capacitor's position along the perimeter. The optimization was performed using electromagnetic simulations, by computing the electric field (E) and temperature inside of the brain and targeting tumor tissues for focus temperature application. The coils were compared with a general-use symmetric coil array for head heating.</p><p><strong>Results: </strong>The optimization of the coil array was able to focus electric field and make temperature rise at the cancer areas. The temperature in Tumor 1 before and after standard and the proposed method optimization was 43.6°C, 48.3°C, and 42.5°C and for Tumor 2 the temperatures were 44.2°C, 43.1°C, and 42.9°C, respectively. Although the standard optimization method exhibits higher temperatures, it also had higher temperatures outside the tumors area.</p><p><strong>Conclusion: </strong>We demonstrated the optimization of array coils with different capacitor positions to obtain focused heating temperatures.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Two-pulse Phase-modulated (TPPM) ¹H Decoupling in a Clinical MR Scanner for the Detection of the C1-glycogen Peak in ¹³C MRS.","authors":"Hideto Kuribayashi, Toshiro Inubushi","doi":"10.2463/mrms.tn.2024-0117","DOIUrl":"https://doi.org/10.2463/mrms.tn.2024-0117","url":null,"abstract":"<p><p>Two-pulse phase-modulated (TPPM) ¹H-decoupling pulse sequence repeats a pair of 180^o RF pulses while changing the signs of the RF phase modulation angle and has been widely used for the ¹³C NMR of organic solids. TPPM was introduced into the ¹³C MRS pulse sequence on a clinical 3T MR scanner, and the ¹H-decoupling performance was compared with conventional ¹H-decoupling schemes using aqueous solutions containing glucose and oyster glycogen. The ¹³C C1-glucose peaks were ¹H-decoupled using TPPM with B₂ = 500 Hz, and the optimal RF phase modulation angle was up to 30^o. Cycling sidebands were not observed when TPPM was used but were observed when WALTZ-16 was used. The ¹³C C1-glycogen peak was ¹H-decoupled even with reducing TPPM duration to 8 ms, which reduced simulated specific absorption rate (SAR) to 39%. In conclusion, the TPPM ¹H decoupling is applicable to clinical MR scanners, and the low-SAR sequence may be more valuable at 7T.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature of the Intracellular-contrast-enhancing Fat-saturated T1-weighted Gradient-echo (ICE-TIGRE) Sequence: A Fat-suppressed T1-weighted Technique with Motion-sensitised Driven-equilibrium for Improved Contrast Enhancement in Liver Imaging.","authors":"Takashi Nishihara, Yuko Nakamura, Nobuyuki Yoshizawa, Masahiro Takizawa, Toru Shirai, Toru Higaki, Yukiko Honda, Kazuo Awai, Yoshitaka Bito","doi":"10.2463/mrms.tn.2023-0104","DOIUrl":"10.2463/mrms.tn.2023-0104","url":null,"abstract":"<p><p>Gadoxetic acid is both an extracellular- and hepatocyte-specific contrast agent. Signals from the extracellular space may lower the contrast between lesions and the surrounding hepatic parenchyma. To improve hepatocyte-specific enhancement, we developed an intracellular contrast-enhancing fat-saturated T1-weighted gradient-echo nature of the sequence (ICE-TIGRE). It incorporates the motion-sensitized driven-equilibrium (MSDE) pulse to suppress signals from the blood flow. We investigated the optimal ICE-TIGRE scanning parameters, i.e., the order of the MSDE and the fat saturation pulses, the duration time, and the b value of the MSDE pulse, using a phantom and three volunteers without applying gadoxetic acid. ICE-TIGRE successfully increased the contrast between the liver parenchyma and the portal vein. To maintain fat saturation, the preparation pulse order should be MSDE-fat saturation. A duration time of 21 ms should be applied to minimize the effect of the T2 factor on the T1 contrast, and a b value of 60 s/mm² should be applied to maximize the diffusion contrast for ICE-TIGRE with the imaging system used in this study.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"133-143"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voxel-based Morphometry of Alzheimer's Disease Using a Localizer Image: A Comparative Study with Magnetization Prepared Rapid Acquisition with Gradient Echo.","authors":"Shohei Inui, Daita Kaneda, Keita Sakurai, Yuto Uchida, Osamu Abe, Yoshio Hashizume","doi":"10.2463/mrms.mp.2023-0093","DOIUrl":"10.2463/mrms.mp.2023-0093","url":null,"abstract":"<p><strong>Purpose: </strong>Magnetization prepared rapid acquisition with gradient echo (MPRAGE) sequence is a gold-standard technique for voxel-based morphometry (VBM) because of high spatial resolution and excellent tissue contrast, especially between gray matter (GM) and white matter (WM). Despite its benefits, MPRAGE exhibits distinct challenge for VBM in some patients with neurological disease because of long scan time and motion artifacts. Speedily acquired localizer images may alleviate this problem. This study aimed to evaluate the feasibility of VBM using 3D Fast Low Angle Shot image captured for localizer (L3DFLASH).</p><p><strong>Methods: </strong>Consecutive 13 patients with pathologically confirmed Alzheimer's disease (AD) (82 ± 9 years) and 21 healthy controls (HC) (79 ± 4 years) were included in this study. Whole-brain L3DFLASH and MPRAGE were captured and preprocessed using the Computational Anatomy Toolbox 12 (CAT12). Agreement with MPRAGE was evaluated for L3DFLASH using regional normalized volume for segmented brain areas. In addition to brain volume difference on VBM and Bland-Altman analysis, atrophic pattern of AD on VBM was evaluated using L3DFLASH and MPRAGE.</p><p><strong>Results: </strong>Acquisition time was 18 s for L3DFLASH and 288 s for MPRAGE. There was a slight systematic difference in all regional normalized volumes from L3DFLASH and MPRAGE. For the whole cohort, GM volume measured from MPRAGE was greater than that from L3DFLASH in most of the region on VBM. When AD and HC were compared, AD-related atrophic pattern was demonstrated in both L3DFLASH and MPRAGE on VBM, although the difference was noted in significant clusters between them.</p><p><strong>Conclusion: </strong>Although systematic difference was noted in regional brain volume measured from L3DFLASH and MPRAGE, AD-related atrophic pattern was preserved in L3DFLASH on VBM. VBM, using speedily acquired localizer image, may provide limited but useful information for evaluating brain atrophy.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"103-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Air Absorption through Arachnoid Granulation: New Considerations from Transsphenoidal Surgery and Implications for Neurofluid Dynamics.","authors":"Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka","doi":"10.2463/mrms.bc.2023-0122","DOIUrl":"10.2463/mrms.bc.2023-0122","url":null,"abstract":"<p><p>Postsurgery intracranial air usually diminishes, presumably merging with cerebrospinal fluid (CSF) and venous circulation. Our study presents two transsphenoidal surgery cases, highlighting potential air absorption by arachnoid granulation (AG)-an underexplored phenomenon. AG has long been deemed pivotal for CSF absorption, but recent perspectives suggest a significant role in waste clearance, neuroinflammation, and neuroimmunity. These cases may stimulate renewed research on the multifaceted role of AG in neurofluid dynamics and potentially elucidate further AG functions.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"144-147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89721422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution Diffusion-weighted Imaging of the Prostate Using Multiplexed Sensitivity-encoding: Comparison with the Conventional and Reduced Field-of-view Techniques.","authors":"Atsushi Nakamoto, Hiromitsu Onishi, Takahiro Tsuboyama, Hideyuki Fukui, Takashi Ota, Keigo Yano, Kengo Kiso, Toru Honda, Hiroyuki Tarewaki, Yoshihiro Koyama, Mitsuaki Tatsumi, Noriyuki Tomiyama","doi":"10.2463/mrms.mp.2023-0039","DOIUrl":"10.2463/mrms.mp.2023-0039","url":null,"abstract":"<p><strong>Purpose: </strong>To compare objective and subjective image quality, lesion conspicuity, and apparent diffusion coefficient (ADC) of high-resolution multiplexed sensitivity-encoding diffusion-weighted imaging (MUSE-DWI) with conventional DWI (c-DWI) and reduced FOV DWI (rFOV-DWI) in prostate MRI.</p><p><strong>Methods: </strong>Forty-seven patients who underwent prostate MRI, including c-DWI, rFOV-DWI, and MUSE-DWI, were retrospectively evaluated. SNR and ADC of normal prostate tissue and contrast-to-noise ratio (CNR) and ADC of prostate cancer (PCa) were measured and compared between the three sequences. Image quality and lesion conspicuity were independently graded by two radiologists using a 5-point scale and compared between the three sequences.</p><p><strong>Results: </strong>The SNR of normal prostate tissue was significantly higher with rFOV-DWI than with the other two DWI techniques (P ≤ 0.01). The CNR of the PCa was significantly higher with rFOV-DWI than with MUSE-DWI (P < 0.05). The ADC of normal prostate tissue measured by rFOV-DWI was lower than that measured by MUSE-DWI and c-DWI (P < 0.01), while there was no difference in the ADC of cancers. In the qualitative analysis, MUSE-DWI showed significantly higher scores than rFOV-DWI and c-DWI for visibility of anatomy and overall image quality in both readers, and significantly higher scores for distortion in one of the two readers (P < 0.001). There was no difference in lesion conspicuity between the three sequences.</p><p><strong>Conclusion: </strong>High-resolution MUSE-DWI showed higher image quality and reduced distortion compared to c-DWI, while maintaining a wide FOV and similar ADC quantification, although no difference in lesion conspicuity was observed.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"58-65"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71416390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular Dysfunction in Patients with Idiopathic Dilated Cardiomyopathy: Quantitative Assessment with Phase Contrast Cine MR Imaging of the Coronary Sinus.","authors":"Masafumi Takafuji, Masaki Ishida, Satoshi Nakamura, Kei Nakata, Haruno Ito, Takanori Kokawa, Kensuke Domae, Suguru Araki, Shiro Nakamori, Junko Ishiura, Kaoru Dohi, Hajime Sakuma","doi":"10.2463/mrms.mp.2023-0018","DOIUrl":"10.2463/mrms.mp.2023-0018","url":null,"abstract":"<p><strong>Purpose: </strong>The purposes of this study were to compare global coronary flow reserve (CFR) between patients with idiopathic dilated cardiomyopathy (DCM) and risk-matched controls using cardiac MRI (CMR), and to evaluate the relationship between global CFR and CMR left ventricular (LV) parameters.</p><p><strong>Methods: </strong>Twenty-six patients with DCM and 26 risk-matched controls who underwent comprehensive CMR examination, including stress-rest coronary sinus flow measurement by phase contrast (PC) cine CMR were retrospectively studied. LV peak global longitudinal, radial, and circumferential strains (GLS, GRS, and GCS) were determined by feature tracking.</p><p><strong>Results: </strong>Patients with DCM had significantly lower global CFR compared with the risk-matched controls (2.87 ± 0.86 vs. 4.03 ± 1.47, P = 0.001). Among the parameters, univariate linear regression analyses revealed significant correlation of global CFR with LV end-diastolic volume index (r = -0.396, P = 0.045), LV mass index (r = -0.461, P = 0.018), GLS (r = -0.558, P = 0.003), and GRS (r = 0.392, P = 0.047). Multiple linear regression analysis revealed GLS as the only independent predictor of global CFR (standardized β = -0.558, P = 0.003).</p><p><strong>Conclusion: </strong>Global CFR was significantly impaired in patients with idiopathic DCM and independently associated with LV GLS, suggesting that microvascular dysfunction may contribute to deterioration of LV function in patients with idiopathic DCM.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"10-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritumoral Fat Content Identified Using Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-squares Estimation (IDEAL) Correlates with Breast Cancer Prognosis.","authors":"Natsumi Hirano Tani, Yuki Koreeda, Aya Nawata, Akitaka Fujisaki, Yoshiko Hayashida, Shohei Shimajiri, Toshiyuki Nakayama, Masanori Hisaoka, Yuzuru Inoue, Keiji Hirata, Yuko Tashima, Fumihiro Tanaka, Takatoshi Aoki","doi":"10.2463/mrms.mp.2023-0127","DOIUrl":"10.2463/mrms.mp.2023-0127","url":null,"abstract":"<p><strong>Purpose: </strong>Adipocytes around aggressive breast cancer (BC) are less lipid different from naive adipocytes (cancer-associated adipocytes, CAAs), and peritumoral edema caused by the release of cytokines from CAAs can conduce to decrease the peritumoral fat proportion. The purpose of this study was to correlate peritumoral fat content identified by using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) with lymph node metastasis (LNM) and recurrence-free survival (RFS) in BC patients and to compare with T2-weighted (T2WI) and diffusion-weighted images (DWI) analyses.</p><p><strong>Methods: </strong>This retrospective study consisted of 85 patients who were diagnosed with invasive carcinoma of breast and underwent breast MRI, including IDEAL before surgery. The scan time of fat fraction (FF) map imaging using IDEAL was 33s. Four regions of interest (ROIs), which are 5 mm from the tumor edge, and one ROI in the mammary fat of the healthy side were set on the FF map. Then average peritumoral FF values (TFF), average FF values on the healthy side (HFF), and peritumoral fat ratio (PTFR, which is defined as TFF/HFF) were calculated. Tumor apparent diffusion coefficient (ADC) values were measured on ADC map obtained by DWI. Peritumoral edema was classified into three grades based on the degree of signal intensity around the tumor on T2WI (T2 edema).</p><p><strong>Results: </strong>The results of stepwise logistic regression analysis for four variables (TFF, PTFR, T2 edema, and ADC value) indicated that TFF and T2 edema were significant factors of LNM (P < 0.01). RFS was significantly associated with TFF (P = 0.016), and 47 of 49 (95.9%) patients with TFF more than 85.5% were alive without recurrence.</p><p><strong>Conclusion: </strong>Peritumoral fat content identified by using IDEAL is associated with LNM and RFS and may therefore be a useful prognostic biomarker for BC.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"112-121"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}