Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine最新文献

{"title":"Preparation and MR Imaging Study of a Recombinant Surface Antibody Superparamagnetic Iron Oxide Nanoparticle-EPC1 Molecular Probe for Hepatic Alveolar Echinococcosis.","authors":"Weili Tian, Wenchao Ji, Wenya Liu, Peng Chen, Jun Li, Xueqi Sheng, Yaomiao Dong","doi":"10.2463/mrms.mp.2025-0096","DOIUrl":"10.2463/mrms.mp.2025-0096","url":null,"abstract":"<p><strong>Purpose: </strong>To establish a new hepatic alveolar echinococcosis (HAE) model, construct an EPC1 antibody-conjugated superparamagnetic iron oxide nanoparticle (SPION) molecular probe and evaluate the probe's efficacy in the targeted MRI of HAE.</p><p><strong>Methods: </strong>Thirty C57 female mice (9-10 weeks; 17-22g) were used to establish an HAE model via hepatic portal vein infection. Twenty successfully HAE-modeled mice were randomly divided into a control group, which was given a simple SPION tracer, and an experimental group, which was given a complex SPION-EPC1 tracer. In addition, a blocking group (n = 5), in which mice received an excess dose of free EPC1 antibody prior to injection of the SPION-EPC1 tracer, was included to assess EPC1-dependent targeting, and a gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) group (n = 5), which received 0.1 mmol/kg of Gd-DTPA, was included to provide a reference clinical contrast agent. MRI was performed using an animal MRI scanner, and T1- and T2-weighted imaging sequences were utilized to assess lesion characteristics before and after tracer injection at 1 and 4h time points. Subsequently, T2 signal intensity, the lesion SNR, and the lesion-to-liver contrast-to-noise ratio were measured by 2 blinded physicians (>5 years experience) using ImageJ software. Comparisons were made between plain and post-injection scans at 1 and 4h. Independent sample t-tests and non-parametric tests were applied to compare signal intensities and SNR values.</p><p><strong>Results: </strong>The SPION-EPC1 probe significantly decreased T2 signal intensity and lesion SNR in the experimental group at both 1 (T2 intensity: -24.3%; SNR: -35.2%) and 4h (T2 intensity: -23.5%; SNR: -43.1%) compared with plain scans. By contrast, the control group showed only transient decreases, with no significant differences at 4h. In the EPC1-blocking group, the T2-signal decrease at 4h was markedly attenuated compared with that of the SPION-EPC1 group and comparable to that of the SPION group, supporting EPC1-dependent targeting.</p><p><strong>Conclusion: </strong>The SPION-EPC1 molecular probe demonstrated improved sensitivity and long-lasting effects in the MRI detection of HAE lesions, offering a promising tool for early diagnosis and the potential advancement of clinical practice in HAE imaging.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substantially Higher Vestibular Hydrops Agreement in Older Patients Assessed by Non-contrast vs. Contrast-enhanced MRI: A Preliminary Study.","authors":"Shinji Naganawa, Rintaro Ito, Yutaka Kato, Masumi Kobayashi, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone","doi":"10.2463/mrms.mp.2025-0199","DOIUrl":"10.2463/mrms.mp.2025-0199","url":null,"abstract":"<p><strong>Purpose: </strong>This preliminary study aimed to investigate the agreement in endolymphatic hydrops (EH) grading between high-resolution non-contrast and contrast-enhanced HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) techniques in the same subjects and to clarify the effect of patient age on the concordance between the 2 methods.</p><p><strong>Methods: </strong>A retrospective study was performed on 12 patients (24 ears; age range: 24-76 years) suspected of EH, all of whom underwent both non-contrast and 4-hour post-contrast 3T MRI. EH in the cochlea and vestibule was graded by the Nakashima scale. Agreement analyses were assessed using the weighted Cohen's kappa (κ). Statistical significance, including the difference between Younger (24-54 years) and Older (57-76 years) patient subgroups, was determined via bootstrap analysis.</p><p><strong>Results: </strong>The overall agreement between non-contrast and contrast-enhanced methods was fair for both the cochlea (κ = 0.343) and vestibule (κ = 0.398). Subgroup analysis revealed a significant age-related difference in vestibular agreement (P = 0.005), showing substantial agreement in the Older group (κ = 0.795) but only slight agreement in the Younger group (κ = 0.113). No significant age-related difference was found for cochlear agreement. Quantitatively, the non-contrast method demonstrated a significantly lower contrast-to-noise ratio compared to the contrast-enhanced method.</p><p><strong>Conclusion: </strong>The concordance between non-contrast and contrast-enhanced MRI for EH assessment is site- and age-dependent. The substantially higher agreement found in older patients suggests that age-related physiological changes facilitate non-contrast visualization. However, caution is advised when interpreting non-contrast findings in younger patients due to potential risks of vestibular overestimation and cochlear underestimation. Given the preliminary nature and small sample size of this study, further investigations with larger cohorts are necessary to validate these findings and the appropriateness of age-based categorization.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications.","authors":"Lixian Wang, Naoya Oishi, Shin-Ichi Urayama, Takashi Hanakawa","doi":"10.2463/mrms.mp.2025-0159","DOIUrl":"10.2463/mrms.mp.2025-0159","url":null,"abstract":"<p><strong>Purpose: </strong>The postmortem interval (PMI) alters tissue properties that shape quantitative MRI (qMRI) signals. We systematically investigated the effects of PMI on relaxation times, depending on tissue characteristics, in both unfixed and fixed pig brains.</p><p><strong>Methods: </strong>Twelve pig brains (n = 12) were scanned in both unfixed and fixed states at 3 PMI windows (≈12, 24, 48h). Quantitative T1, T2, and T2* maps were acquired with identical protocols at controlled room temperature (~24°C). We assessed the PMI effects on relaxation times in the gray matter (GM) and the white matter (WM) at both group and sample levels, while fixation-induced effects and inter-sample variability were evaluated using pairwise rank correlation and coefficient of variation (CV) visualization.</p><p><strong>Results: </strong>In unfixed tissues, T1 significantly differed among PMI groups in GM (P = 0.0141) and WM (P = 0.0315) in the early window (≤24h). In the same window, PMI-T1 correlations were observed in both GM (r = 0.921, P = 0.007) and WM (r = 0.876, P = 0.013). T2 showed no group differences but exhibited an inverse correlation with PMI in WM (r = -0.849, P = 0.015). No significant PMI-T2* relationships were detected (all P > 0.05). At later PMI (20-50h), PMI-qMRI correlations diminished. Fixation processes altered all qMRI parameters. Notably, the PMI effects on T1 in the unfixed brains were preserved even after fixation at an ordinal level, although fixation introduced substantial inter-sample variability.</p><p><strong>Conclusion: </strong>PMI exerts the most robust effects on T1. Fixation has a significant impact on qMRI values, mitigating the apparent PMI effect and increasing the inter-sample variability. However, it is still possible to retrieve the PMI effects from fixed brain at the level of rank order, providing practical guidance for further ex vivo qMRI studies on PMI.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of T1 and T2 Mapping in Diagnosing Chronic Liver Disease-related Kidney Injury and Monitoring the Outcome of Stem Cell Therapy: An Animal Experimental Study.","authors":"Jiaming Qin, Hongtao Yuan, Chao Wang, Yue Wang, Dan Tong, Zhandong Hu, Chen Zhang, Wen Shen, Shuangshuang Xie","doi":"10.2463/mrms.mp.2025-0098","DOIUrl":"10.2463/mrms.mp.2025-0098","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the monitoring value of T1 and T2 mapping in assessing kidney injury associated with chronic liver disease and the therapeutic efficacy of bone marrow mesenchymal stem cells (BMSCs) treatment.</p><p><strong>Methods: </strong>Thirty-six rats were divided into 6 subgroups (n = 6/group) and underwent MRI scanning at 0, 2, 4, 6, 8, and 12 weeks, respectively, followed by biochemical and histological analyses. Seven rats underwent continuous MRI scanning to monitor changes in imaging parameters. Twenty-four rats divided into BMSC and control group. Six rats per group were subjected to serial MRI scans at weeks 13, 14, 15, and 16, another six rats per group were scanned at week 14 and then sacrificed for biochemical and renal histological analysis.</p><p><strong>Results: </strong>From baseline to 12 weeks, renal hematoxylin and eosin (HE) scores and α-smooth muscle actin (α-SMA) levels increased significantly, and similar trends were found in renal T1 and T2 values. Following BMSCs injection, both BMSC and control groups exhibited reductions in HE scores and α-SMA levels, with BMSC group demonstrating more substantial decreases. Renal T1 and T2 values declined in both groups, with the BMSC group showing significantly lower T2 values than the control group. Strong correlations were found between renal T1/T2 values and HE scores, α-SMA levels (|r|=0.419-0.724). The area under the curve values for T1 and T2 in differentiating renal injury severity across different renal strips were from 0.793 to 0.930.</p><p><strong>Conclusion: </strong>T1 and T2 mapping can effectively monitor renal injury progression in chronic liver disease, with T2 values demonstrating greater potential for assessing the therapeutic efficacy of BMSCs.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Letter to the Editor about \"Endometrial Cancer: A Daily Clinical Practice Guide for Radiologists\" Published Online: August 20, 2025.","authors":"Yumiko Oishi Tanaka","doi":"10.2463/mrms.lte.2025-0172","DOIUrl":"10.2463/mrms.lte.2025-0172","url":null,"abstract":"","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of the Trochlear Nerve Using Deep Learning-enhanced 3D T2-weighted MR Imaging at 3T.","authors":"Taiki Koshiishi, Satoru Ide, Yuka Ishimoto, Tomohiro Shintaku, Sera Kasai, Jusei Kudo, Keita Watanabe, Tetsuya Wakayama, Atsushi Nozaki, Xucheng Zhu, Kana Saito, Mizuki Imura, Amo Ozawa, Shuichi Matsuhashi, Tatsuro Sasaki, Saaya Mori, Masashi Matsuzaka, Shingo Kakeda","doi":"10.2463/mrms.mp.2025-0177","DOIUrl":"10.2463/mrms.mp.2025-0177","url":null,"abstract":"<p><strong>Purpose: </strong>Cranial nerve imaging with 3T MRI commonly uses 3D fast imaging employing steady-state acquisition (3D-FIESTA); however, this sequence has limitations in achieving higher spatial resolution and provides poor tissue contrast between cranial nerves and adjacent vascular structures. We evaluated 3D T2-weighted imaging (T2-CUBE) with deep learning-based reconstruction (DLR) for cranial nerve visualization, focusing on the trochlear nerve, the smallest cranial nerve with the longest intracranial course, and compared it with T2-CUBE without DLR and 3D-FIESTA.</p><p><strong>Methods: </strong>Ten healthy male volunteers (age, 23-40 years; mean age, 32 years) underwent T2-CUBE with and without DLR, and 3D-FIESTA at 3T. Two neuroradiologists independently evaluated trochlear nerve visualization in 4 anatomical segments (origin from the midbrain, cisternal, tentorial, and anterior portion of its cavernous segments) using a 3-point scale, and SNR of the pons (SNR_PONS) and cerebrospinal fluid (SNR_CSF) were calculated.</p><p><strong>Results: </strong>T2-CUBE with DLR achieved a 100% visualization across all trochlear nerve segments and demonstrated significantly better visualization than both T2-CUBE without DLR and 3D-FIESTA (P < 0.025). T2-CUBE without DLR showed 67.5%-100% visualization across the 4 segments. 3D-FIESTA showed 32.5%-80% visualization of the origin from the midbrain, cisternal, and tentorial segments, with no visualization of the cavernous segments. DLR increased SNR_PONS and SNR_CSF by factors of 1.8-2.5 (SNR_PONS: 14.1 vs 5.7; SNR_CSF: 31.8 vs 17.5, respectively; P < 0.001). T2-CUBE with DLR demonstrated significantly higher SNR_PONS than 3D-FIESTA (14.1 vs 6.4, P < 0.001), while SNR_CSF was comparable (31.8 vs 36.3, P = 0.20).</p><p><strong>Conclusion: </strong>T2-CUBE with DLR at 3T provided a significantly better trochlear nerve visualization than T2-CUBE without DLR and 3D-FIESTA. This technique may extend beyond the trochlear nerve to other cranial nerves and to the evaluation of neurovascular compression in the cistern, with the potential to become the new standard for cisternal imaging.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcification Detection versus Lesion Characterization in Breast SWI: Clinical Experiences with Standard Protocols.","authors":"Fadime Güven, Muhammed Halid Yener, Muhammed Emre Işıktaş","doi":"10.2463/mrms.lte.2025-0191","DOIUrl":"10.2463/mrms.lte.2025-0191","url":null,"abstract":"","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Perfusion and Functional Assessment Capabilities of Electrocardiography- and Photoplethysmography-monitored Phase-resolved Functional Lung and Dynamic Contrast-enhanced Perfusion MR Imaging.","authors":"Yoshiyuki Ozawa, Alicia Palomar-García, Masanori Ozaki, Masao Yui, Maiko Shinohara, Natsuka Yazawa, Kaori Yamamoto, Yuichiro Sano, Masato Ikedo, Takahiro Ueda, Masahiko Nomura, Takeshi Yoshikawa, Daisuke Takenaka, Yoshiharu Ohno","doi":"10.2463/mrms.mp.2025-0201","DOIUrl":"10.2463/mrms.mp.2025-0201","url":null,"abstract":"<p><strong>Purpose: </strong>The present study directly compared the quantitative capabilities of regional perfusion and pulmonary functional change assessments among electrocardiography (ECG)- and photoplethysmography (PPG)-monitored phase-resolved functional lung (PREFUL) MRI and dynamic contrast-enhanced (CE) perfusion MRI in thoracic oncologic patients.</p><p><strong>Methods: </strong>Seventeen thoracic oncologic patients prospectively underwent ECG- and PPG-monitored PREFUL MRI, dynamic CE-perfusion MRI, and pulmonary function tests. ECG- and PPG-monitored perfusion-weighted PREFUL MRI (PW-MRI) and quantitative perfusion maps from dynamic CE-perfusion MRI were generated. Regional perfusions were determined using ROI measurements. For each patient, the overall perfusion from each method was determined as the average ROI measurement value. To determine the relationship between regional perfusion among all methods, Pearson's correlations were performed. Tukey's honest significant difference test was performed to compare regional perfusion among ventral, middle, and dorsal slice positions on ECG- and PPG-monitored PW-MRI and quantitative perfusion maps. To assess the pulmonary functional loss evaluation capability of each MRI method, each overall perfusion was correlated with %VC and %FEV₁ using Pearson's correlation.</p><p><strong>Results: </strong>The correlation of regional perfusion between ECG- and PPG-monitored PW-MRI was significant and good (r = 0.79, P < 0.0001). However, the correlations between ECG- or PPG-monitored PW-MRI and quantitative perfusion maps were assessed as significant and fair (ECG: r = 0.4, P < 0.0001; PPG: r = 0.36, P < 0.0001). ECG- and PPG-monitored PW-MRI demonstrated significantly higher perfusion than the quantitative perfusion map (P < 0.0001). Furthermore, ECG-and PPG-monitored PW-MRI and quantitative perfusion maps had significant and moderate correlations (%VC: 0.60 ≤ r ≤ 0.63, P < 0.05; %FEV₁: 0.52 ≤ r ≤ 0.69, P < 0.05).</p><p><strong>Conclusion: </strong>ECG- and PPG-monitored PREFUL MRI had similar potential to dynamic CE-perfusion MRI for quantitatively assessing regional perfusion and pulmonary functional changes in thoracic oncologic patients. Furthermore, PPG-monitored PREFUL MRI showed little difference in regional perfusion evaluation compared with ECG-monitored PREFUL MRI and the potential to play a complementary role in this setting.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory-gating Reduces Motion Artifacts Due to Uterine Displacement in T2-weighted MR Imaging of the Female Pelvis.","authors":"Hironobu Ishikawa, Masahiko Monma, Yoshiyuki Ishimori, Kousaku Saotome, Shiro Ishii, Hirofumi Sekino, Ryo Yamakuni, Takeyasu Kakamu, Daisuke Oura, Yuma Takahashi, Shinya Seino, Masanori Yusa, Hiroshi Ito","doi":"10.2463/mrms.mp.2025-0065","DOIUrl":"10.2463/mrms.mp.2025-0065","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the potential enhancement of image quality in fast-spin-echo T2-weighted images (FSE-T2WI) with respiratory-gating compared to conventional FSE-T2WI and to clarify how abdominal wall motion affects uterine displacement and consequently impacts image quality.</p><p><strong>Methods: </strong>One hundred and three women who underwent pelvic MRI using a 3T-MRI scanner were enrolled. FSE-T2WI with and without respiratory-gating was visually assessed for motion-related artifacts, and the image quality was categorized as poor, moderate, or excellent. The uterus was classified as type 1 (on the bladder), type 2 (not on the bladder and not retroflexed), or type 3 (uterus contacting the vertebrae or a retroflexed uterus). The relationships (1) between the abdominal wall and uterine displacements, (2) between the quality of FSE-T2WI with and without respiratory-gating and uterine displacement, and (3) between uterine displacement and types were investigated.</p><p><strong>Results: </strong>Respiratory-gated FSE-T2WI achieved better overall image quality, with poor, moderate, and excellent ratings observed in 27, 44, and 32 patients, respectively, compared with 53, 34, and 16 patients for conventional FSE-T2WI. Improvement with respiratory-gating was observed in 43 patients, particularly in those with type 1 and type 2 uteri, whereas only 8 patients showed decreased image quality. A strong correlation was found between abdominal wall and uterine displacements (P < 0.001), indicating that uterine motion is largely driven by respiration. The amplitude of uterine displacement was significantly smaller in type 3 uteri (P < 0.05), consistent with fewer motion-related artifacts.</p><p><strong>Conclusion: </strong>Respiratory-gated FSE-T2WI effectively reduces motion artifacts caused by respiratory-induced uterine displacement, particularly in type 1 and type 2 uteri where displacement is pronounced.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147380299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Encoding Distortion Correction of Female Pelvic Diffusion-weighted Imaging on a 1.5-T MR System: Influence on Image Quality and Apparent Diffusion Coefficient Measurements for Both In Vitro and In Vivo Studies.","authors":"Takahiro Ueda, Kaori Yamamoto, Natsuka Yazawa, Yuichiro Sano, Masato Ikedo, Masanori Ozaki, Takahiro Matsuyama, Masahiko Nomura, Yoshiyuki Ozawa, Daisuke Takenaka, Takeshi Yoshikawa, Yoshiharu Ohno","doi":"10.2463/mrms.mp.2025-0202","DOIUrl":"https://doi.org/10.2463/mrms.mp.2025-0202","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether reverse encoding distortion correction (RDC) improves image quality and maintains apparent diffusion coefficient (ADC) measurements in diffusion-weighted imaging (DWI) on female pelvic MRI using a 1.5-T in in vitro and in vivo studies.</p><p><strong>Methods: </strong>This retrospective, institutional review board-approved study included both in vitro and in vivo analyses of 31 women (mean age, 41 ± 15 years; range, 24-80 years) who underwent pelvic MRI between January and March 2022. T2-weighted image (T2WI) and DWI with and without RDC were acquired, and ADC maps were generated. Quantitative metrics included SNR, contrast-to-noise ratio (CNR), ADC values, and deformation ratio (DR), defined as the proportional area discrepancy between DWI and T2WI for the uterine corpus, cervix, ovary, and lesions. Qualitative assessments-overall image quality (OIQ), deformation severity (DS), and diagnostic confidence level (DCL)-were independently scored by 2 blinded radiologists using 5-point scales.</p><p><strong>Results: </strong>In vitro SNR and ADC values showed no significant differences between DWI with and without RDC, with strong correlations to reference measurements (ρ = 0.99, P < 0.001). In vivo, SNR, CNR, and ADC values of the myometrium, cervix, and ovary did not differ significantly between 2 methods (P > 0.05). DRs were significantly lower in DWI with RDC than in DWI without RDC (P ≤ 0.0003). ADC values showed strong correlations between DWI with and without RDC on uterine corpus, cervix, ovary and lesions (ρ = 0.82-0.90, P < 0.001). Qualitative scores improved with RDC: higher OIQ (P = 0.0004), lower DS (P = 0.0004), and higher DCL (P = 0.03). Interobserver agreement ranged from substantial to almost perfect (κ = 0.78-0.97).</p><p><strong>Conclusion: </strong>RDC improves image quality and reduces image distortion in DWI on female pelvic MRI at a 1.5-T, while maintaining ADC measurements in in vitro and in vivo settings.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}