Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine最新文献

{"title":"Comparison of MR Imaging of High-grade Serous Carcinomas with and without Homologous Recombination-deficiency.","authors":"Tsukasa Saida, Ayumi Shikama, Miki Yoshida, Taishi Amano, Toshitaka Ishiguro, Masafumi Sakai, Sodai Hoshiai, Toyomi Satoh, Takahito Nakajima","doi":"10.2463/mrms.mp.2025-0071","DOIUrl":"https://doi.org/10.2463/mrms.mp.2025-0071","url":null,"abstract":"<p><strong>Purpose: </strong>MRI findings of high-grade serous carcinoma (HGSC) with and without homologous recombination deficiency (HRD) were compared to explore the feasibility of using MRI as a genetic predictor.</p><p><strong>Methods: </strong>We retrospectively reviewed MRI data from HRD-positive and HRD-negative HGSC and evaluated tumor size, appearance, apparent diffusion coefficient (ADC), time-intensity curve, and several dynamic contrast-enhanced curve descriptors. Age, primary site, tumor stage, bilaterality, presence of lymph node metastasis, presence of peritoneal metastasis, and tumor marker levels were also compared.</p><p><strong>Results: </strong>Forty-eight patients with HRD-positive HGSC (17 patients with BRCA1 variant, 9 patients with BRCA2 variant, and 22 without BRCA variants) and 18 patients with HRD-negative HGSC were included. The HRD-negative patients' mean age was 67 years, which was significantly higher than that of the HRDpositive patients (60 years, P = 0.011). High-risk time-intensity curve (TIC) patterns were more common in HRD-negative tumors (94%) than in HRD-positive tumors (63%; P = 0.047). Tumors without HRD exhibited significantly higher wash-in rates (P = 0.023). Additionally, unresectable lymph node metastases were significantly more frequent in HRD-negative patients (P = 0.013). No significant differences were observed in the other evaluated factors.</p><p><strong>Conclusion: </strong>The comparison between HGSC with and without HRD revealed that HGSC without HRD was significantly associated with older age, a higher likelihood of exhibiting a high-risk TIC pattern, a higher wash-in rate, and a higher frequency of unresectable lymph node metastasis.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple Frame-based Approach for MR Imaging-guided Abdominal Biopsy: Preliminary Evaluation in a Phantom Model.","authors":"Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou, Antreas Chrysanthou, Antonis Christofi, Cleanthis Ioannides, Liyang Yu, Christakis Damianou","doi":"10.2463/mrms.mp.2024-0187","DOIUrl":"https://doi.org/10.2463/mrms.mp.2024-0187","url":null,"abstract":"<p><strong>Purpose: </strong>Although automation offers several benefits in MRI-guided abdominal biopsies, the conventional surgeon-centric approach continues to be the preferred technique. This study presents an ergonomic biopsy device aimed at streamlining the MRI-guided abdominal biopsy process while preserving operator control.</p><p><strong>Methods: </strong>A dedicated belt was designed with adjustable straps to accommodate patients of varying sizes. A biopsy frame with 2 manual degrees of freedom was movably affixed to the belt, allowing for adjustable positioning across the patient's circumference to align with the region of interest. Preliminary testing was performed on an abdominal biopsy phantom with 2 embedded 7-mm tumor mimics in a 3T MRI scanner. Needle guide registration in MRI coordinates was achieved by attaching a water-filled syringe to the guide, which was then navigated to align with each target using a straightforward method involving the acquisition and fusion of parallel images. A clinically relevant half-Fourier acquisition single-shot turbo spin echo sequence was used for both the initial alignment and for intermittent imaging during the stepwise advancement of a metallic clinical needle toward the target.</p><p><strong>Results: </strong>The device was easy to use, even for a non-experienced operator. The employed methodology enabled straightforward calculation of the 2D path for aligning the syringe with the target. Alignment accuracy was within the submillimeter range. The employed sequence was robust against susceptibility artifacts, enabling precise guidance, with the accuracy of tumor puncture ultimately dependent on the operator.</p><p><strong>Conclusion: </strong>The proposed biopsy method has the potential to enhance stability and accuracy over traditional techniques, while being more ergonomic and cost-effective than advanced robotic systems, also maintaining human control. Extensive preclinical and clinical evaluation is needed to fully assess effectiveness and safety.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Echo-planar Imaging with Compressed Sensitivity Encoding (EPICS) in the Evaluation of Small Breast Cancers Using Diffusion-weighted Imaging with Background Suppression (DWIBS).","authors":"Toshiki Kazama, Yui Nagafuji, Naoki Niikura, Takuho Okamura, Marc Van Cauteren, Makoto Obara, Susumu Takano, Natsuo Konta, Tomohiko Horie, Taro Takahara, Nobue Kumaki, Tetsu Niwa, Jun Hashimoto","doi":"10.2463/mrms.mp.2023-0151","DOIUrl":"10.2463/mrms.mp.2023-0151","url":null,"abstract":"<p><strong>Purpose: </strong>High b-value acquisition and diffusion-weighted imaging with background suppression (DWIBS) are desirable in high-specificity breast cancer diagnosis on non-contrast-enhanced magnetic resonance imaging; however, this inherently results in a lower signal-to-noise ratio (SNR). Compressed sensitivity encoding (C-SENSE), which combines SENSE with compressed sensing, improves the SNR by reducing noise. Recent technological improvements allow us to incorporate this acceleration technique into echo-planar imaging, called echo-planar imaging with C-SENSE (EPICS). This study aimed to compare image quality and reliability of the apparent diffusion coefficient (ADC) between DWIBS obtained using SENSE and EPICS in patients with small breast cancers.</p><p><strong>Methods: </strong>Thirty-seven patients with pathologically confirmed breast cancer underwent DWIBS, and images were reconstructed using both conventional SENSE (SENSE-DWIBS) and EPICS (EPICS-DWIBS). Two board-certified radiologists independently evaluated lesion conspicuity (LC) and noise using a 5-point grading scale. The same 2 radiologists independently measured SNR, contrast-to-noise ratio (CNR), and the mean cancer ADC. The Pearson coefficient and Bland-Altman plot were applied to assess the accuracy of ADCs.</p><p><strong>Results: </strong>LC scores were higher with EPICS than with SENSE, reaching significance for one reviewer but not the other reviewer. Noise ratings on visual evaluation were significantly lower with EPICS than with SENSE (P < 0.001 for both reviewers). SNR was significantly higher with EPICS than with SENSE (P < 0.005 for both reviewers). CNR was significantly higher with EPICS than with SENSE (P < 0.001 for both reviewers). Bland-Altman plots of cancer ADCs using EPICS-DWIBS and SENSE-DWIBS showed excellent concordance, with a bias of 0.026 × 10^-3 mm²/s and limits of agreement ranging 0.054 × 10^-3 mm²/s; the Pearson's correlation coefficient was 0.997 (P < 0.0001).</p><p><strong>Conclusion: </strong>EPICS enhances breast DWIBS image quality, with improved SNR and CNR and reduced noise levels. The ADCs of breast cancers obtained using EPICS were almost perfectly correlated with those obtained using conventional SENSE.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution and Clinical Impact of Deep Learning Technologies in Breast MRI.","authors":"Tomoyuki Fujioka, Shohei Fujita, Daiju Ueda, Rintaro Ito, Mariko Kawamura, Yasutaka Fushimi, Takahiro Tsuboyama, Masahiro Yanagawa, Akira Yamada, Fuminari Tatsugami, Koji Kamagata, Taiki Nozaki, Yusuke Matsui, Noriyuki Fujima, Kenji Hirata, Takeshi Nakaura, Ukihide Tateishi, Shinji Naganawa","doi":"10.2463/mrms.rev.2024-0056","DOIUrl":"10.2463/mrms.rev.2024-0056","url":null,"abstract":"<p><p>The integration of deep learning (DL) in breast MRI has revolutionized the field of medical imaging, notably enhancing diagnostic accuracy and efficiency. This review discusses the substantial influence of DL technologies across various facets of breast MRI, including image reconstruction, classification, object detection, segmentation, and prediction of clinical outcomes such as response to neoadjuvant chemotherapy and recurrence of breast cancer. Utilizing sophisticated models such as convolutional neural networks, recurrent neural networks, and generative adversarial networks, DL has improved image quality and precision, enabling more accurate differentiation between benign and malignant lesions and providing deeper insights into disease behavior and treatment responses. DL's predictive capabilities for patient-specific outcomes also suggest potential for more personalized treatment strategies. The advancements in DL are pioneering a new era in breast cancer diagnostics, promising more personalized and effective healthcare solutions. Nonetheless, the integration of this technology into clinical practice faces challenges, necessitating further research, validation, and development of legal and ethical frameworks to fully leverage its potential.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro Detection of Intramammary-like Macrocalcifications Using Susceptibility-weighted MR Imaging Techniques at 1.5T.","authors":"Annett Lebenatus, Josephine Kuster, Sina Straub, Hendrik Naujokat, Karolin Tesch, Olav Jansen, Mona Salehi Ravesh","doi":"10.2463/mrms.mp.2024-0075","DOIUrl":"10.2463/mrms.mp.2024-0075","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The aim of our study was to investigate the technical accuracy of susceptibility-weighted imaging (SWI) and quantitative susceptibility mapping (QSM) created to detect intramammary-like calcifications depending on different TEs, volume, and type of calcification samples at 1.5T.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Jello-embedded particles of blackboard chalk and ostrich eggshell ranging in size from 4 to 25 mm&lt;sup&gt;2&lt;/sup&gt; were used to simulate intramammary calcifications after testing different base substances and calcifications for their suitability to be used in breast phantoms. Breast phantoms were systematically examined using CT and an optimized 3D multi-echo gradient echo pulse sequence with following parameters: TR/TE, 22/1.88-15.52 ms in 1.24 ms increments; reconstructed voxel, 0.5 × 0.5 × 1.1 mm&lt;sup&gt;3&lt;/sup&gt;; receiver bandwidth, 1120 Hz/Px; flip angle, 15°; integrated parallel imaging technique with a GeneRalized Autocalibrating Partial Parallel Acquisition (GRAPPA) factor of 2/24; and a total acquisition time of 3:00 min. A qualitative evaluation of the dependence of the visualization of calcification samples on volume and TE value was followed by a calculation of the SNR, the contrast-to-noise ratio (CNR) and the creation of SWI and QSM in the sense of a (semi)-quantitative analysis of the images.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Jello proved to be a suitable base substance for preparing breast phantoms for SW MRI. Blackboard chalk and ostrich eggshell proved to be suitable for mimicking intramammary-like calcifications. The decrease in the median SNR of the blackboard chalk samples was significantly higher than the corresponding value of the ostrich eggshell samples over the entire TE range (47.5 to 17.0 vs. 16.0 to 6.56, P &lt; 0.0001). The increase in the median CNR of the blackboard chalk samples was significantly higher than the corresponding value of the ostrich eggshell samples over the entire TE range (2.46 to 35.0 vs. 20.2 to 36.8, P = 0.007). With increasing TE value, the signal void volume of the calcification particle increases in the magnitude images as well as in SWI and QSM. Due to the blooming effect, the median gradients of the TE-based changes in signal void volumes were higher in SWI than in magnitude images and in QSM, regardless of the type of calcification particle examined. The maximum magnetic susceptibility of ostrich eggshell samples varied in a TE range of 1.88 to 15.52 ms from -7.2 to -2.51 ppm and that of blackboard chalk from -2.0 to -1.7 ppm. Compared to the manually measured volumes of the calcification particles, both MR-based measurements and CT examinations overestimated the actual sample size. The (non)-significant overestimation in the MRI-data is dependent on the set TE. The CT-based hyperdense volumes were overestimated compared to the corresponding manually measured sample volumes in a range of 109.8%-315.2% for ostrich eggshell samples (P = 0.016) and in a range of 39.9%-156.","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion-weighted Echo Planar Imaging with Compressed SENSE (EPICS-DWI) for Pancreas Assessment: A Multicenter Study.","authors":"Tetsuro Kaga, Yoshifumi Noda, Masashi Asano, Nobuyuki Kawai, Kimihiro Kajita, Yukiko Takai, Fumitaka Ejima, Fuminori Hyodo, Hiroki Kato, Yoshihiko Fukukura, Masayuki Matsuo","doi":"10.2463/mrms.mp.2024-0046","DOIUrl":"10.2463/mrms.mp.2024-0046","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the feasibility of single-shot echo planar diffusion-weighted imaging with compressed SENSE (EPICS-DWI) for pancreas assessment by comparing with single-shot echo planar DWI with parallel imaging (PI-DWI).</p><p><strong>Methods: </strong>This multicenter prospective study included 27 consecutive participants with untreated pancreatic ductal adenocarcinoma (PDAC) (15 men; mean age, 67 ± 10 years) who underwent pancreatic protocol MRI including both PI-DWI and EPICS-DWI. Two radiologists independently and randomly reviewed the high b-value DWI images and qualitatively assigned confidence scores for overall image quality, image noise, pancreas conspicuity, and PDAC conspicuity using a 5-point scale. One radiologist measured the PDAC-to-pancreas contrast-to-noise-ratio (CNR) on high b-value DWI images and the apparent diffusion coefficient (ADC) value of PDAC. Qualitative and quantitative parameters were compared between PI-DWI and EPICS-DWI using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>The confidence scores for overall image quality (P < 0.001 in both radiologists) and image noise (P < 0.001 in both radiologists) were higher in EPICS-DWI than in PI-DWI. The pancreas conspicuity was better in EPICS-DWI than in PI-DWI in one of the radiologists (P = 0.02 and 0.06). The PDAC conspicuity was comparable between PI-DWI and EPICS-DWI (P > 0.99 in both radiologists). The PDAC-to-pancreas CNR was higher in EPICS-DWI than in PI-DWI (P = 0.02), while the ADC value of PDAC in PI-DWI was not significantly different compared to that in EPICS-DWI (P = 0.48).</p><p><strong>Conclusion: </strong>The image quality and PDAC-to-pancreas CNR was improved in EPICS-DWI compared to PI-DWI. However, the conspicuity and ADC value of PDAC were comparable between PI-DWI and EPICS-DWI.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Protein Concentration in Cerebrospinal Fluid with T₂ Component Analysis.","authors":"Tatsuya Koizumi, Seiko Shimizu, Chihiro Akiba, Hidenori Kakizoe, Hideki Bandai, Kenichi Sato, Hidekazu Nagasawa, Ikuko Ogino, Madoka Nakajima, Shinya Yamada, Koichi Oshio, Masakazu Miyajima","doi":"10.2463/mrms.mp.2023-0157","DOIUrl":"10.2463/mrms.mp.2023-0157","url":null,"abstract":"<p><strong>Purpose: </strong>T₂ values are hypothesized to be reduced where protein accumulates in the cerebrospinal fluid (CSF). We aimed to verify the accuracy of Carr-Purcell-Meiboom-Gil (CPMG) pulses and non-negative least squares (NNLS) analysis in visualizing protein concentrations by mapping the T₂ values.</p><p><strong>Methods: </strong>We first dissolved 1.2g of bovine serum albumin powder in 4 mL of artificial CSF to purify an albumin solution with a concentration of 4.5 mM. Artificial CSF was added thereto, and eight types of albumin solutions, with concentrations of 0.002-4.5 mM, were purified. We acquired this albumin solution with CPMG pulses and NNLS, decomposed the T₂ values per pixel, and derived 25 T₂ component values of 60-2000 ms. We assessed the change of T₂ values by the difference in albumin concentration of a single voxel. Finally, we used the method to assess T₂ values from two patients, one with a subdural hematoma and one with a suprasellar cystic tumor. T₂ component values were plotted graphically, presented individually, and created in color maps.</p><p><strong>Results: </strong>T₂ component values for albumin concentrations ranging from 0.056 to 4.55 mM showed different T₂ peaks, whereas, for concentrations 0.002 to 0.019 mM, the peaks were similar heights and overlapped. Peak width was similar for all concentrations. The color maps successfully reflected the changes in T₂ values across both RGB color patterns. T₂ components for albumin samples with 2.5 mM and 6.1 mM concentrations within a single voxel were represented separately and reflected the ratio of the two samples in nine different regions of interest within one slice. In the clinical cases, the T₂ component map imaged differences in albumin concentrations, similar to those observed in the albumin samples.</p><p><strong>Conclusion: </strong>The present method with CPMG sequences and NNLS provide adequate images to differentiate accumulating protein concentrations in the CSF, even at the level of a single pixel.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Solute Movement Direction and Intracranial Clearance via Vitreous Gadolinium-based Contrast Agent MR Imaging: Potential as a Novel Biomarker for Glymphatic Dysfunction.","authors":"Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone","doi":"10.2463/mrms.mp.2025-0127","DOIUrl":"https://doi.org/10.2463/mrms.mp.2025-0127","url":null,"abstract":"<p><strong>Purpose: </strong>The ocular and brain glymphatic systems may share common physiological pathways. We hypothesized that the anteroposterior movement of gadolinium-based contrast agent (GBCA) that has leaked into the vitreous could serve as a biomarker for brain glymphatic function. This study aimed to retrospectively investigate the association between the intravitreal GBCA distribution on MRI and recently proposed imaging markers of impaired brain waste clearance.</p><p><strong>Methods: </strong>We analyzed 156 eyes from 78 adult participants who underwent 3T MRI 4 hr after standard-dose GBCA administration. On 3D-real IR images, we calculated a \"contrast shift index\" (the signal difference between anterior and posterior vitreous volumes of interest: VOIa-VOIp) to quantify the anteroposterior GBCA distribution. The primary outcome was a composite endpoint of positivity for either putative meningeal lymphatics at the posterior sigmoid sinus (PML-PSS) or enhanced basal ganglia perivascular spaces (PVS-BG). Multivariable logistic regression with cluster-robust inference was used to assess predictors, including the contrast shift index, mean vitreous contrast distribution, age, sex, and axial length of the eye.</p><p><strong>Results: </strong>A positive contrast shift index, indicating preferential anterior GBCA distribution, was significantly and independently associated with the composite outcome of impaired brain clearance (P = 0.006). Age (P <0.001) and male sex (P = 0.009) were also independent predictors. A predictive model incorporating these factors demonstrated high discrimination, with an area under the receiver operating characteristic curve (AUC) of 0.872. Axial length of the eye and mean vitreous contrast distribution were not significant independent predictors.</p><p><strong>Conclusion: </strong>The anteroposterior distribution of GBCA in the vitreous is a novel, non-invasive imaging biomarker associated with impaired brain clearance function. This \"contrast shift index\" may reflect systemic glymphatic dysregulation common to both the eye and brain, offering a new avenue for assessing neurodegenerative risk.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Resolution TOF-MRA Using Compressed Sensing-based Deep Learning Image Reconstruction for the Visualization of Lenticulostriate Arteries: A Preliminary Study.","authors":"Yuya Hirano, Noriyuki Fujima, Hiroyuki Kameda, Kinya Ishizaka, Jihun Kwon, Masami Yoneyama, Kohsuke Kudo","doi":"10.2463/mrms.mp.2024-0025","DOIUrl":"10.2463/mrms.mp.2024-0025","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the visibility of the lenticulostriate arteries (LSAs) in time-of-flight (TOF)-MR angiography (MRA) using compressed sensing (CS)-based deep learning (DL) image reconstruction by comparing its image quality with that obtained by the conventional CS algorithm.</p><p><strong>Methods: </strong>Five healthy volunteers were included. High-resolution TOF-MRA images with the reduction (R)-factor of 1 were acquired as full-sampling data. Images with R-factors of 2, 4, and 6 were then reconstructed using CS-DL and conventional CS (the combination of CS and sensitivity conceding; CS-SENSE) reconstruction, respectively. In the quantitative assessment, the number of visible LSAs (identified by two radiologists), length of each depicted LSA (evaluated by one radiological technologist), and normalized mean squared error (NMSE) value were assessed. In the qualitative assessment, the overall image quality and the visibility of the peripheral LSA were visually evaluated by two radiologists.</p><p><strong>Results: </strong>In the quantitative assessment of the DL-CS images, the number of visible LSAs was significantly higher than those obtained with CS-SENSE in the R-factors of 4 and 6 (Reader 1) and in the R-factor of 6 (Reader 2). The length of the depicted LSAs in the DL-CS images was significantly longer in the R-factor 6 compared to the CS-SENSE result. The NMSE value in CS-DL was significantly lower than in CS-SENSE for R-factors of 4 and 6. In the qualitative assessment of DL-CS images, the overall image quality was significantly higher than that obtained with CS-SENSE in the R-factors 4 and 6 (Reader 1) and in the R-factor 4 (Reader 2). The visibility of the peripheral LSA was significantly higher than that shown by CS-SENSE in all R-factors (Reader 1) and in the R-factors 2 and 4 (Reader 2).</p><p><strong>Conclusion: </strong>CS-DL reconstruction demonstrated preserved image quality for the depiction of LSAs compared to the conventional CS-SENSE when the R-factor is elevated.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Benign, Borderline, and Malignant Ovarian Seromucinous Neoplasms on MR Imaging.","authors":"Tsukasa Saida, Miki Yoshida, Toshitaka Ishiguro, Sodai Hoshiai, Masafumi Sakai, Taishi Amano, Saki Shibuki, Toyomi Satoh, Takahito Nakajima","doi":"10.2463/mrms.mp.2024-0064","DOIUrl":"10.2463/mrms.mp.2024-0064","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare MRI findings among benign, borderline, and malignant ovarian seromucinous neoplasms.</p><p><strong>Methods: </strong>We retrospectively analyzed MRI data from 24 patients with ovarian seromucinous neoplasms-seven benign, thirteen borderline, and six malignant. The parameters evaluated included age, tumour size, morphology, number, height, apparent diffusion coefficient (ADC) values, T2 ratios, time-intensity curve (TIC) descriptors, and TIC patterns of the mural nodules. Additionally, we examined the T2 and T1 ratios of the cyst contents, tumour markers, and the presence of endometriosis. We used statistical tests, including the Kruskal-Wallis and Fisher-Freeman-Halton exact tests, to compare these parameters among the three aforementioned groups.</p><p><strong>Results: </strong>The cases showed papillary architecture with internal branching in 57% of benign, 92% of borderline, and 17% of malignant cases. Three or fewer mural nodules were seen in 57% of benign, 8% of borderline, and 17% of malignant cases. Compared to benign and borderline tumours, mural nodules of malignant neoplasms had significantly increased height (P = 0.015 and 0.011, respectively), lower means ADC values (P = 0.003 and 0.035, respectively). The mural nodules in malignant cases also demonstrated significantly lower T2 ratios than those in the benign cases (P = 0.045). Most neoplasms displayed an intermediate-risk TIC pattern, including 80% benign, 83% borderline, and 60% malignant neoplasms, and no significant differences were observed.</p><p><strong>Conclusion: </strong>Most benign and borderline tumours exhibited a papillary architecture with an internal branching pattern, whereas this feature was less common in malignant neoplasms. Additionally, benign tumours had fewer mural nodules compared to borderline tumours. Malignant neoplasms were characterized by mural nodules with increased height and lower ADC values than those in benign and borderline tumours. Interestingly, all three groups predominantly exhibited an intermediate-risk TIC pattern, emphasizing the complexity of diagnosing seromucinous neoplasms using MRI.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}