Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine最新文献

{"title":"Axillary Lymphadenopathy after COVID-19 Vaccination: Follow-up for Enlarged Lymph Nodes on MR Imaging.","authors":"Noriko Kanemaru, Takeharu Yoshikawa, Soichiro Miki, Takahiro Nakao, Yuta Nakamura, Kotaro Fujimoto, Osamu Abe","doi":"10.2463/mrms.mp.2023-0147","DOIUrl":"10.2463/mrms.mp.2023-0147","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate the longitudinal MRI characteristic of COVID-19-vaccination-related axillary lymphadenopathy by evaluating the size, T2-weighted signal intensity, and apparent diffusion coefficient (ADC) values.</p><p><strong>Methods: </strong>COVID-19-vaccination-related axillary lymphadenopathy was observed in 90 of 433 health screening program participants on the chest region of whole-body axial MRIs in 2021, as reported in our previous study. Follow-up MRI was performed at an interval of approximately 1 year after the second vaccination dose from 2022 to 2023. The diameter, signal intensity on T2-weighted images, and ADC of the largest enlarged lymph nodes were measured on chest MRI. The values were compared between the post-vaccination MRI and the follow-up MRI, and statistically analyzed.</p><p><strong>Results: </strong>Out of the 90 participants who had enlarged lymph nodes of 5 mm or larger in short axis after the second vaccination dose, 76 participants (45 men and 31 women, mean age: 61 years) were enrolled in the present study. The median short- and long-axis diameter of the enlarged lymph nodes was 7 mm and 9 mm for post-vaccination MRI and 4 mm and 6 mm for follow-up MRI, respectively. The median signal intensity relative to the muscle on T2-weighted images decreased (5.1 for the initial post-vaccination MRI and 3.6 for the follow-up MRI, P < .0001). The ADC values did not show a notable change and remained in a normal range.</p><p><strong>Conclusion: </strong>The enlarged axillary lymph nodes decreased both in size and in signal intensity on T2-weighted images of follow-up MRI. The ADC remained unchanged. Our findings may provide important information to establish evidence-based guidelines for conducting proper assessment and management of post-vaccination lymphadenopathy.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"176-183"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Diffusion-weighted MR Imaging for Evaluating the Depth of Invasion in Oral Tongue Squamous Cell Carcinoma.","authors":"Hiroki Tanaka, Sho Koyasu, Masahiro Kikuchi, Mami Iima, Koichi Omori, Yuji Nakamoto","doi":"10.2463/mrms.mp.2023-0137","DOIUrl":"10.2463/mrms.mp.2023-0137","url":null,"abstract":"<p><strong>Purpose: </strong>The 8th edition of the American Joint Committee on Cancer staging system included the depth of invasion (DOI) for the T classification of oral cancer. However, no standardized method has been established to clinically measure the DOI. This study aimed to investigate the accuracy of MRI-based DOI for oral tongue squamous cell carcinoma (OTSCC) in each MRI sequence.</p><p><strong>Methods: </strong>We enrolled 49 patients with histologically proven OTSCC, treated surgically between April 2017 and February 2021. We divided the DOI into three groups using 5 and 10 mm, the thresholds for determining the T stage, and retrospectively evaluated the agreement between MRI-based DOI and pathological DOI (pDOI) for each MRI sequence, axial T1-weighted imaging (T1WI), T2-weighted imaging with fat suppression (FS-T2WI), contrast-enhanced T1WI with fat suppression (CE-T1WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps. We also divided the DOI into two groups using 3 mm, the threshold for considering elective neck dissection, and evaluated the overestimation rate of MRI-based DOI in lesions with pDOI ≤ 3 mm.</p><p><strong>Results: </strong>With 5-mm and 10-mm divisions, the accuracy of the DOI assessment was highest on DWI (0.82, weighted kappa = 0.85). With a 3-mm division, the accuracy was also highest on DWI (0.87, kappa = 0.73). The overestimation rate of the MRI-based DOI in lesions with pDOI ≤ 3 mm was lowest on DWI (27.8%).</p><p><strong>Conclusion: </strong>DOI on DWI exhibits a comparatively higher rate of concordance with pDOI. DWI may be more useful than other MRI sequences in evaluating the DOI of OTSCC.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"210-219"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Suspicious Breast Lesions Visible Only on MR Imaging: Is It Possible to Classify into Immediate Biopsy and Careful Observation Groups?","authors":"Ryozo Kai, Mitsuhiro Tozaki, Yuya Koike, Aya Nagata, Kanae Taruno, Yoshimitsu Ohgiya","doi":"10.2463/mrms.mp.2023-0065","DOIUrl":"10.2463/mrms.mp.2023-0065","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the characteristics of suspicious MRI-only visible lesions and to explore the validity of subcategorizing these lesions into the following two groups: lesions that would require immediate biopsy (4Bi) and lesions for which careful clinical follow-up could be recommended (4Fo).</p><p><strong>Methods: </strong>A retrospective review of 108 MRI-only visible lesions in 106 patients who were diagnosed as Breast Imaging Reporting and Data System (BI-RADS) category 4 between June 2018 and June 2022 at our institution was performed by two radiologists. The breast MR images were evaluated according to BI-RADS and additional MRI descriptors (linear ductal, branching, and apparent diffusion coefficient values). The lesions were categorized by previously reported classification systems, and the positive predictive values (PPVs) for the different categories were determined and compared. Subsequently, a new classification system was developed in this study.</p><p><strong>Results: </strong>The total malignancy rate was 31% (34/108). No significant differences between benign and malignant lesions were identified for focus and mass lesions. For non-mass lesions, linear ductal and heterogeneous internal enhancement suggested a benign lesion (P = 0.0013 and P = 0.023, respectively), and branching internal enhancement suggested malignancy (P = 0.0066). Segmental distribution suggested malignancy (P = 0.0097). However, the PPV of segmental distribution with heterogeneous enhancement was significantly lower than that of category 4 segmental lesions with other enhancement patterns (11% vs. 59%; P = 0.0198).As a new classification, the distribution of focal, linear, and segmental was given a score of 0, 1, or 2, and the internal enhancement of heterogeneous, linear-ductal, clumped, branching, and clustered-ring enhancement was given a score of 0, 1, 2, 3, and 4, respectively. When categorized using a scoring system, a statistically significant difference in PPV was observed between 4Fo (n = 27) and 4Bi (n = 33) (7% vs. 61%, P = 0.000029).</p><p><strong>Conclusion: </strong>The new classification system was found to be highly capable of subcategorizing BI-RADS category 4 MRI-only visible non-mass lesions into 4Fo and 4Bi.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"229-240"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Diffusion-weighted Imaging (DWI) for Assessing Cerebrospinal Fluid Dynamics: DWI-fluidography in the Brains of Healthy Subjects.","authors":"Shunrou Fujiwara, Kuniaki Ogasawara, Kohei Chida, Yasushi Ogasawara, Jun-Ichi Nomura, Sotaro Oshida, Kentaro Fujimoto, Shota Tsutsui, Kengo Setta, Yoshichika Yoshioka","doi":"10.2463/mrms.mp.2022-0152","DOIUrl":"10.2463/mrms.mp.2022-0152","url":null,"abstract":"<p><strong>Purpose: </strong>The present study aimed to investigate whether diffusion-weighted imaging (DWI) can qualify and quantify cerebrospinal fluid (CSF) dynamics in the brains of healthy subjects. For this purpose, we developed new DWI-based fluidography and compared the CSF dynamics seen on the fluidography with two apparent diffusion coefficients obtained with different DWI signal models at anatomical spaces filled by CSF.</p><p><strong>Methods: </strong>DWI with multiple b values was performed for 10 subjects using a 7T MRI scanner. DWI-fluidography based on the DWI signal variations in different motion probing gradient directions was developed for visualizing the CSF dynamics voxel-by-voxel. DWI signals were measured using an ROI in the representative CSF-filled anatomical spaces in the brain. For the multiple DWI signals, the mono-exponential and kurtosis models were fitted and two kinds of apparent diffusion coefficients (ADC_C and ADC_K) were estimated in each space using the Gaussian and non-Gaussian diffusion models, respectively.</p><p><strong>Results: </strong>DWI-fluidography could qualitatively represent the features of CSF dynamics in each anatomical space. ADCs indicated that the motions at the foramen of Monro, the cistern of the velum interpositum, the quadrigeminal cistern, the Sylvian cisterns, and the fourth ventricle were more drastic than those at the subarachnoid space and anterior horns of the lateral ventricle. Those results seen in ADCs were identical to the findings on DWI-fluidography.</p><p><strong>Conclusion: </strong>DWI-fluidography based on the features of DWI signals could show differences of CSF dynamics among anatomical spaces.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"166-175"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney R2* Mapping for Noninvasive Evaluation of Iron Overload in Paroxysmal Nocturnal Hemoglobinuria.","authors":"Koichi Ito, Kazuyuki Ohgi, Koichiro Kimura, Koichi Ishitaki, Akiyoshi Yamashita, Hiroyuki Yokote, Shunji Tsukuda, Ko Matsushita, Yuko Naraoka, Amon Fujioka, Tatsuki Ono","doi":"10.2463/mrms.mp.2023-0114","DOIUrl":"10.2463/mrms.mp.2023-0114","url":null,"abstract":"<p><strong>Purpose: </strong>The kidney iron deposition can cause kidney damage and renal insufficiency in paroxysmal nocturnal hemoglobinuria (PNH) patients. Assessment of iron deposition in the kidney is essential for the early diagnosis of renal damage in PNH patients. The purpose of this study was to evaluate kidney R2* (T2* reciprocals) values in PNH patients using the iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ).</p><p><strong>Methods: </strong>Two radiologists measured the R2* values of the renal cortex in 14 PNH patients and 13 healthy volunteers using IDEAL-IQ. Lactate dehydrogenase (LDH), a reliable marker of intravascular hemolysis, was also measured in all participants.</p><p><strong>Results: </strong>The kidney R2* values were significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). High inter-operator reproducibility of the measurements was also acquired using IDEAL-IQ. LDH levels were also significantly higher in PNH patients compared with those in healthy volunteers (P < 0.001). Kidney R2* values strongly correlated with LDH levels in PNH patients.</p><p><strong>Conclusion: </strong>IDEAL-IQ has a possibility of becoming a useful method for the noninvasive evaluation of renal iron overload in PNH patients.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"204-209"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Structures in a Human Embryo Imaged with MR Microscopy.","authors":"Kazuki Kunieda, Kazuyuki Makihara, Shigehito Yamada, Masayuki Yamaguchi, Takashi Nakamura, Yasuhiko Terada","doi":"10.2463/mrms.mp.2023-0110","DOIUrl":"10.2463/mrms.mp.2023-0110","url":null,"abstract":"<p><strong>Purpose: </strong>To delineate brain microstructures in human embryos during the formation of the various major primordia by MR microscopy, with different contrasts appropriate for each target.</p><p><strong>Methods: </strong>We focused mainly on the internal structures in the cerebral cortex and the accessory nerves of the brain. To find appropriate sequence parameters, we measured nuclear magnetic resonance (NMR) parameters and created kernel density plots of T1 and T2 values. We performed T1-weighted gradient echo imaging with parameters similar to those used in the previous studies. We performed T2*-weighted gradient echo imaging to delineate the target structures with the appropriate sequence parameters according to the NMR parameter and flip angle measurements. We also performed high-resolution imaging with both T1- and T2*-weighted sequences.</p><p><strong>Results: </strong>T1, T2, and T2* values of the target tissues were positively correlated and shorter than those of the surrounding tissues. In T1-weighted images with a voxel size of (30 µm)³ and (20 µm)³, various organs and tissues and the agarose gel were differentiated as in previous studies, and the structure of approximately 40 µm in size was depicted, but the detailed structures within the cerebral cortex and the accessory nerves were not delineated. In T2*-weighted images with a voxel size of (30 µm)³, the layered structure within the cerebral cortex and the accessory nerves were clearly visualized. Overall, T1-weighted images provided more information than T2*-weighted images, but important internal brain structures of interest were visible only in T2*-weighted images. Therefore, it is essential to perform MR microscopy with different contrasts.</p><p><strong>Conclusion: </strong>We have visualized brain structures in a human embryo that had not previously been delineated by MR microscopy. We discussed pulse sequences appropriate for the structures of interest. This methodology would provide a way to visualize crucial embryological information about the anatomical structure of human embryos.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"191-203"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for Contrast-enhanced MR Imaging Protocols and Quantitative Assessment of Wall Enhancement for Vessel Wall Imaging in Various Intracranial Arterial Diseases.","authors":"Naoko Mori","doi":"10.2463/mrms.lte.2023-0173","DOIUrl":"10.2463/mrms.lte.2023-0173","url":null,"abstract":"","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"276-277"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 3D Magnetization-transfer- and Spectral-presaturation-with-inversion-recovery-based Neuromelanin Imaging.","authors":"Midori Kusama, Yukio Kimura, Masami Yoneyama, Takashi Namiki, Takeshi Tamaru, Kenji Miyagi, Noriko Sato","doi":"10.2463/mrms.mp.2023-0095","DOIUrl":"10.2463/mrms.mp.2023-0095","url":null,"abstract":"<p><strong>Purpose: </strong>Neuromelanin is visualized by optimizing the conditions of longitudinal relaxation (T1)-weighted imaging (T1WI). Although it was originally developed in 2D imaging, 3D imaging has been also reported, and T1WI sequences with magnetization transfer (MT) pulses are now widely used in 3D gradient echo (GRE) sequences. In this study, we assert that the use of spectral presaturation with inversion recovery (SPIR) may also be useful as an alternative to MT pulses, and we optimize SPIR and compare it with MT.</p><p><strong>Methods: </strong>Neuromelanin images with MT pulse and SPIR (flip angles [FAs] = 19º, 22º, and 25º) were acquired from 30 healthy volunteers. To achieve the same acquisition time of 5 min, the slab thickness of the MT images was less than 1/3 of those of the SPIR images; the acquisition areas for MT and SPIR were the brainstem and the whole brain, respectively. Visual and quantitative evaluation was performed and compared on the four sequences acquired for the substantia nigra pars compacta (SNc) and the locus coeruleus (LC). For visual assessment, we used the mean score from a 3-point scale by two evaluators. For quantitative evaluation, the contrast ratios of SNc and LC were calculated in comparison with the background tissue signal.</p><p><strong>Results: </strong>In visual assessments, the mean scores of the SPIR FA19º and FA22º images were better than others in the SNc. Regarding LC, the SPIR FA22º image yielded the best mean score. In quantitative evaluations, the MT image was significantly lower than the other three images in SNc. Regarding LC, there were no significant differences among the four acquired images (MT and SPIR FA19º, FA22º, and FA25º).</p><p><strong>Conclusions: </strong>Detection of neuromelanin in SNc and LC was improved by the use of SPIR compared to MT pulse in 3D neuromelanin imaging.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"184-190"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Properties of a Chemically Fixed Human Embryo Visualized with Quantitative Susceptibility Mapping.","authors":"Toru Shirai, Yasuhiko Terada, Katsumi Kose, Shigehito Yamada","doi":"10.2463/mrms.tn.2023-0149","DOIUrl":"10.2463/mrms.tn.2023-0149","url":null,"abstract":"<p><p>A chemically fixed Carnegie stage 23 (approximately 56 days of gestation) human embryo specimen was imaged using 3D spin-echo and gradient-echo sequences in a static magnetic field strength of 4.74T, and a quantitative susceptibility map was calculated using the 3D gradient-echo image. The acquired 3D microscopic images (90 μm cube voxel size) clarified the relationship between R₂ (transverse relaxation rate), R₂* (apparent transverse relaxation rate), and magnetic susceptibility in the heart, liver, kidney, and spinal cord. The results suggested that the R₂* and magnetic susceptibility in each tissue were probably due to paramagnetic iron ions originating from erythrocytes. The large R₂* (~130 s^-1) and magnetic susceptibility (~0.122 ppm) in the liver were attributed to its hemopoietic function. A large magnetic susceptibility (~0.116 ppm) was also observed in the spinal cord, but we conclude that more detailed future studies are needed.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":"262-268"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR Imaging Features Predictive of Pathologic Complete Response and Survival Outcomes for Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.","authors":"Ahmet Bozer, Cengiz Yilmaz, Hülya Çetin Tunçez, Demet Kocatepe Çavdar, Zehra Hilal Adıbelli","doi":"10.2463/mrms.mp.2024-0137","DOIUrl":"https://doi.org/10.2463/mrms.mp.2024-0137","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the predictive value of MRI features for pathologic complete response (pCR) and survival outcomes in patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NAC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 168 BC patients treated with NAC between 2018 and 2022. Pre-NAC breast MRI scans were evaluated for enhancement patterns, time-intensity curve (TIC), peritumoral edema, and background enhancement. Both pre- and post-NAC MRIs were assessed for Epeak %, mean apparent diffusion coefficient (ADC) value, and ADC ratio (mean ADC of lesion/contralateral normal breast parenchyma). Survival outcomes were analyzed using Kaplan-Meier and Cox regression models.</p><p><strong>Results: </strong>pCR was achieved in 34% of patients. MRI demonstrated a sensitivity of 74% and a specificity of 86% in predicting pCR, with an overall accuracy of 82%. The post-NAC percentage of initial peak enhancement (Epeak) was significantly lower in the pCR group (P < 0.001). Multivariate analysis identified a pre-NAC Epeak ≤ 96 (hazard ratio [HR]: 6.26, P < 0.001) and a post-NAC Epeak > 188 (HR: 18.40, P < 0.001) as independent risk factors for disease-free survival. Additionally, a lower pre-NAC ADC ratio (≤0.65) was associated with poorer overall survival (HR: 2.8, P: 0.041). Pre-NAC peritumoral edema, background enhancement, and TIC were not significant predictors of survival outcomes.</p><p><strong>Conclusion: </strong>MRI features, including Epeak % and ADC ratio, are important predictors of pCR and survival outcomes in BC patients undergoing NAC. Incorporating these biomarkers into clinical practice may improve treatment planning and optimize patient outcomes.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}