Mami Iima, Rena Nakayama, Masako Kataoka, Martins Otikovs, Noam Nissan, Lucio Frydman, Yuta Urushibata, Maya Honda, Aika Okazawa, Hiroko Satake, Shinji Naganawa, Yuji Nakamoto
{"title":"比较乳腺高分辨率弥散加权成像中病变的明显性和 ADC 可靠性","authors":"Mami Iima, Rena Nakayama, Masako Kataoka, Martins Otikovs, Noam Nissan, Lucio Frydman, Yuta Urushibata, Maya Honda, Aika Okazawa, Hiroko Satake, Shinji Naganawa, Yuji Nakamoto","doi":"10.2463/mrms.tn.2024-0089","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the breast lesion conspicuity and apparent diffusion coefficient (ADC) reliability for three different diffusion-weighted imaging (DWI) protocols: spatiotemporal encoding (SPEN), single-shot echo-planar imaging (SS-EPI), and readout segmentation of long variable echo-trains (RESOLVE).</p><p><strong>Methods: </strong>Sixty-five women suspected of having breast tumors were included in this study, with 44 lesions (36 malignant, 8 benign) analyzed further. Breast MRI was performed on a 3 Tesla (3T) system (MAGNETOM Prisma, Siemens) equipped with a dedicated 18-channel breast array coil for a phantom and patients. Three DWI protocols-SPEN, SS-EPI, and RESOLVE-were used. SS-EPI was acquired with an in-plane resolution of 2 × 2 mm<sup>2</sup>, a slice thickness of 3 mm, and b-values of 0 and 1000 s/mm<sup>2</sup>. SPEN had a higher in-plane resolution of 1 × 1 mm<sup>2</sup>, a slice thickness of 1.5 mm, and b-values of 0, 850, and 1500 s/mm<sup>2</sup>. RESOLVE was acquired with an in-plane resolution of 1 × 1 mm<sup>2</sup>, a slice thickness of 1.5 mm, and b-values of 0 and 850 s/mm<sup>2</sup>. Lesion conspicuity and ADC values were evaluated.</p><p><strong>Results: </strong>The average lesion conspicuity scores were significantly higher for RESOLVE (3.54 ± 0.65) than for SPEN (3.07 ± 0.91) or SS-EPI (2.48 ± 0.78) (P < 0.01). The SPEN score was significantly higher than the SS-EPI score (P < 0.01). Phantom measurements indicated marginally lower ADC values for SPEN compared to SS-EPI and RESOLVE across all concentrations. The results revealed that SPEN (b = 0, 850, 1500 sec/mm<sup>2</sup>) yielded significantly lower ADC values compared to SPEN (b = 0, 850 sec/mm<sup>2</sup>) in malignant lesions (P < 0.01), with no significant difference observed between SPEN (b = 0, 850 sec/mm<sup>2</sup>), SS-EPI, and RESOLVE. For benign lesions, no significant difference in ADC values was found between SPEN (b = 0, 850 sec/mm<sup>2</sup>), SPEN (b = 0, 850, 1500 sec/mm<sup>2</sup>), SS-EPI, and RESOLVE.</p><p><strong>Conclusion: </strong>RESOLVE provided the highest lesion conspicuity, and ADC values in breast lesions were not significantly different among sequences ranging b values 850-1000 sec/mm<sup>2</sup>. SPEN with higher b-values (0, 850, 1500 vs. 0, 850 sec/mm<sup>2</sup>) yielded significantly lower ADC values in malignant lesions, highlighting the importance of b-value selection in ADC quantification.</p>","PeriodicalId":94126,"journal":{"name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing Lesion Conspicuity and ADC Reliability in High-resolution Diffusion-weighted Imaging of the Breast.\",\"authors\":\"Mami Iima, Rena Nakayama, Masako Kataoka, Martins Otikovs, Noam Nissan, Lucio Frydman, Yuta Urushibata, Maya Honda, Aika Okazawa, Hiroko Satake, Shinji Naganawa, Yuji Nakamoto\",\"doi\":\"10.2463/mrms.tn.2024-0089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study investigated the breast lesion conspicuity and apparent diffusion coefficient (ADC) reliability for three different diffusion-weighted imaging (DWI) protocols: spatiotemporal encoding (SPEN), single-shot echo-planar imaging (SS-EPI), and readout segmentation of long variable echo-trains (RESOLVE).</p><p><strong>Methods: </strong>Sixty-five women suspected of having breast tumors were included in this study, with 44 lesions (36 malignant, 8 benign) analyzed further. Breast MRI was performed on a 3 Tesla (3T) system (MAGNETOM Prisma, Siemens) equipped with a dedicated 18-channel breast array coil for a phantom and patients. Three DWI protocols-SPEN, SS-EPI, and RESOLVE-were used. SS-EPI was acquired with an in-plane resolution of 2 × 2 mm<sup>2</sup>, a slice thickness of 3 mm, and b-values of 0 and 1000 s/mm<sup>2</sup>. SPEN had a higher in-plane resolution of 1 × 1 mm<sup>2</sup>, a slice thickness of 1.5 mm, and b-values of 0, 850, and 1500 s/mm<sup>2</sup>. RESOLVE was acquired with an in-plane resolution of 1 × 1 mm<sup>2</sup>, a slice thickness of 1.5 mm, and b-values of 0 and 850 s/mm<sup>2</sup>. Lesion conspicuity and ADC values were evaluated.</p><p><strong>Results: </strong>The average lesion conspicuity scores were significantly higher for RESOLVE (3.54 ± 0.65) than for SPEN (3.07 ± 0.91) or SS-EPI (2.48 ± 0.78) (P < 0.01). The SPEN score was significantly higher than the SS-EPI score (P < 0.01). Phantom measurements indicated marginally lower ADC values for SPEN compared to SS-EPI and RESOLVE across all concentrations. The results revealed that SPEN (b = 0, 850, 1500 sec/mm<sup>2</sup>) yielded significantly lower ADC values compared to SPEN (b = 0, 850 sec/mm<sup>2</sup>) in malignant lesions (P < 0.01), with no significant difference observed between SPEN (b = 0, 850 sec/mm<sup>2</sup>), SS-EPI, and RESOLVE. For benign lesions, no significant difference in ADC values was found between SPEN (b = 0, 850 sec/mm<sup>2</sup>), SPEN (b = 0, 850, 1500 sec/mm<sup>2</sup>), SS-EPI, and RESOLVE.</p><p><strong>Conclusion: </strong>RESOLVE provided the highest lesion conspicuity, and ADC values in breast lesions were not significantly different among sequences ranging b values 850-1000 sec/mm<sup>2</sup>. SPEN with higher b-values (0, 850, 1500 vs. 0, 850 sec/mm<sup>2</sup>) yielded significantly lower ADC values in malignant lesions, highlighting the importance of b-value selection in ADC quantification.</p>\",\"PeriodicalId\":94126,\"journal\":{\"name\":\"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2463/mrms.tn.2024-0089\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2463/mrms.tn.2024-0089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparing Lesion Conspicuity and ADC Reliability in High-resolution Diffusion-weighted Imaging of the Breast.
Purpose: This study investigated the breast lesion conspicuity and apparent diffusion coefficient (ADC) reliability for three different diffusion-weighted imaging (DWI) protocols: spatiotemporal encoding (SPEN), single-shot echo-planar imaging (SS-EPI), and readout segmentation of long variable echo-trains (RESOLVE).
Methods: Sixty-five women suspected of having breast tumors were included in this study, with 44 lesions (36 malignant, 8 benign) analyzed further. Breast MRI was performed on a 3 Tesla (3T) system (MAGNETOM Prisma, Siemens) equipped with a dedicated 18-channel breast array coil for a phantom and patients. Three DWI protocols-SPEN, SS-EPI, and RESOLVE-were used. SS-EPI was acquired with an in-plane resolution of 2 × 2 mm2, a slice thickness of 3 mm, and b-values of 0 and 1000 s/mm2. SPEN had a higher in-plane resolution of 1 × 1 mm2, a slice thickness of 1.5 mm, and b-values of 0, 850, and 1500 s/mm2. RESOLVE was acquired with an in-plane resolution of 1 × 1 mm2, a slice thickness of 1.5 mm, and b-values of 0 and 850 s/mm2. Lesion conspicuity and ADC values were evaluated.
Results: The average lesion conspicuity scores were significantly higher for RESOLVE (3.54 ± 0.65) than for SPEN (3.07 ± 0.91) or SS-EPI (2.48 ± 0.78) (P < 0.01). The SPEN score was significantly higher than the SS-EPI score (P < 0.01). Phantom measurements indicated marginally lower ADC values for SPEN compared to SS-EPI and RESOLVE across all concentrations. The results revealed that SPEN (b = 0, 850, 1500 sec/mm2) yielded significantly lower ADC values compared to SPEN (b = 0, 850 sec/mm2) in malignant lesions (P < 0.01), with no significant difference observed between SPEN (b = 0, 850 sec/mm2), SS-EPI, and RESOLVE. For benign lesions, no significant difference in ADC values was found between SPEN (b = 0, 850 sec/mm2), SPEN (b = 0, 850, 1500 sec/mm2), SS-EPI, and RESOLVE.
Conclusion: RESOLVE provided the highest lesion conspicuity, and ADC values in breast lesions were not significantly different among sequences ranging b values 850-1000 sec/mm2. SPEN with higher b-values (0, 850, 1500 vs. 0, 850 sec/mm2) yielded significantly lower ADC values in malignant lesions, highlighting the importance of b-value selection in ADC quantification.
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