Expert opinion on drug delivery最新文献_第6页

On the cellular selectivity of targeting peptide-nanoparticle conjugates - a nanoparticle perspective. 靶向肽-纳米粒子偶联物的细胞选择性——纳米粒子视角。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-01 Epub Date: 2025-06-21 DOI: 10.1080/17425247.2025.2522245

Bastian Beitzinger, Bastian Draphoen, Janina Hald, Markus Krämer, Tamara Rudolf, Felicitas Schmitt, Philipp Schwarz, Mika Lindén

引用次数: 0

Engineering trafficking pathways to overcome immunosuppressive barriers in solid tumor immunotherapy. 在实体瘤免疫治疗中克服免疫抑制障碍的工程运输途径。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-26 DOI: 10.1080/17425247.2025.2551717

Sthiti Porna Dutta, Shaily Chauhan, Piyush Kumar Gupta

引用次数: 0

Infusion-based drug delivery to the brain: what's next? 以输注为基础的药物输送到大脑：下一步是什么？

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-14 DOI: 10.1080/17425247.2025.2545878

Tian Yuan, Yi Yang, Wenbo Zhan, Ferdinando Rodriguez Y Baena, Daniele Dini

引用次数: 0

Recent advances in dissolving microneedle delivery systems for breast cancer therapy. 用于乳腺癌治疗的溶解微针输送系统的最新进展。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-12 DOI: 10.1080/17425247.2025.2547016

Jingqi Sun, Yutong Zhao, Zicong Xu, Xiao-Ling Xu, Jin Su

{"title":"Recent advances in dissolving microneedle delivery systems for breast cancer therapy.","authors":"Jingqi Sun, Yutong Zhao, Zicong Xu, Xiao-Ling Xu, Jin Su","doi":"10.1080/17425247.2025.2547016","DOIUrl":"10.1080/17425247.2025.2547016","url":null,"abstract":"Introduction: Breast cancer, a malignancy characterized by high recurrence and mortality rates, faces critical bottlenecks in conventional therapies including systemic toxicity and insufficient drug concentration at lesion sites. Dissolving microneedles (DMNs) are micron-scale arrays fabricated from biodegradable materials. By leveraging their unique capability to penetrate the epidermal barrier and deliver drugs with precision, DMNs pioneer a novel therapeutic approach for breast cancer treatment.Areas covered: This review provides new insights and directions for breast cancer research by systematically examining the latest advances in DMNs for breast cancer treatment. We comprehensively analyze DMNs mechanisms for localized delivery of chemotherapeutics, targeted degraders, immunomodulators, and gene editors, while assessing synergistic combinations with nanotechnology, physical therapies, and immunotherapy to overcome drug resistance and immunosuppression.Expert opinion: Based on the literature review, DMNs demonstrate potential for breast cancer therapy through localized multi-agent delivery and combination strategies, significantly improving treatment efficacy for superficial tumors while minimizing systemic exposure.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-17"},"PeriodicalIF":5.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain targeting for the treatment of obesity: update of current knowledge and potential applications of nanomedicine and peptide conjugation. 脑靶向治疗肥胖：纳米药物和肽解结的最新知识和潜在应用。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-06 DOI: 10.1080/17425247.2025.2542290

Sonya Salamone, Sara Manin, Teresa Musumeci, Claudia Carbone, Angela Bonaccorso, Rosalia Rodriguez-Rodriguez, Rosario Pignatello

{"title":"Brain targeting for the treatment of obesity: update of current knowledge and potential applications of nanomedicine and peptide conjugation.","authors":"Sonya Salamone, Sara Manin, Teresa Musumeci, Claudia Carbone, Angela Bonaccorso, Rosalia Rodriguez-Rodriguez, Rosario Pignatello","doi":"10.1080/17425247.2025.2542290","DOIUrl":"10.1080/17425247.2025.2542290","url":null,"abstract":"Introduction: There is growing evidence about the efficacy of natural compounds and peptides as central-acting anti-obesity drugs; on the other hand, their pharmacokinetic profile often hampers the clinical application. In this narrative review, the critical role of nanomedicine and peptide conjugation is reported as a promising strategy to overcome these limits.Areas covered: The focus areas were centrally acting drugs for obesity, providing context about pathways involved and past and currently approved medications, pointing out their limits. The last 10 years research was analyzed to collect the progress in central-acting anti-obesity drugs and the new potential strategies (nanomedicine and conjugation), with attention on natural compounds and peptides.Expert opinion: Based on literature review, nanocarriers and conjugation strategies can offer targeted delivery of both natural molecules and peptides, enhancing their therapeutics, improving cellular uptake, and regulating metabolism and inflammatory pathways. The choice of the proper administration route, along with a delivery strategy significantly impacts the pharmacokinetics and therapeutic outcomes of compounds delivered through nanomedicines and encourages their translation 'from bench to bedside.'","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-16"},"PeriodicalIF":5.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in antibacterial nanoformulations for endodontic applications. 牙髓应用抗菌纳米制剂的最新进展。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1080/17425247.2025.2511963

Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte

{"title":"Recent advances in antibacterial nanoformulations for endodontic applications.","authors":"Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte","doi":"10.1080/17425247.2025.2511963","DOIUrl":"10.1080/17425247.2025.2511963","url":null,"abstract":"Introduction: Nanotechnology offers a promising avenue for developing new biomedical materials and improving existing dental techniques, particularly in endodontics. Advances in antibacterial nanoformulations could revolutionize root canal treatment by overcoming challenges such as anatomical complexity, bacterial biofilms, and disinfectant resistance. Nanoparticles in disinfectants and sealers enhance infection control, while in regenerative therapies, they aid in bioactive compound release and scaffold enhancement.Areas covered: This review explores recent research developments in antibacterial nanoformulations tailored for endodontic applications. It covers the principles of endodontic therapy, current protocols, efficacy rates, limitations, and the potential benefits and drawbacks of nanoparticle integration. Additionally, it discusses different nanoparticle types, their efficacy, biocompatibility, and mechanisms of action against endodontic pathogens. The references examined in this review are primarily drawn from studies conducted over the last decade, ensuring an up-to-date perspective on the topic.Expert opinion: We provide an overview of the transformative potential of antibacterial nanoformulations in endodontics, highlighting their advantages over conventional methods, which often show low effectiveness against endodontic flora, application challenges, and high reactivity with biological tissues. Chitosan, silver, and poly(lactic-co-glycolic acid) nanoparticles have shown strong antimicrobial activity and superior dentinal penetration. Integration into irrigants, sealers, and regenerative scaffolds, enhance efficacy while maintaining or improving material properties. Ongoing research is essential to optimize their design, ensure safety, and support regulatory approval. These innovations may redefine clinical standards and improve treatment outcomes in endodontics.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1117-1136"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications. 抗坏血酸衍生物的自组装结构：包封特性和受控药物递送应用。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1080/17425247.2025.2510301

Sofía G Brignone, Silvia Tampucci, Belkys A Maletto, Daniel A Allemandi, Patrizia Chetoni, Santiago D Palma

{"title":"Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications.","authors":"Sofía G Brignone, Silvia Tampucci, Belkys A Maletto, Daniel A Allemandi, Patrizia Chetoni, Santiago D Palma","doi":"10.1080/17425247.2025.2510301","DOIUrl":"10.1080/17425247.2025.2510301","url":null,"abstract":"Introduction: The chemical instability and low liposolubility of ascorbic acid have driven the development of hydrophobic derivatives that not only enhance its stability but also enable the formation of self-assembled systems for controlled drug delivery. These systems have garnered increasing interest due to their potential to improve drug administration by enhancing solubility, protecting against degradation, and enabling controlled or targeted release.Areas covered: This review critically explores the development and application of self-assembled systems derived from ascorbic acid compounds, including micelles, microemulsions, aspasomes, and other nanostructures. A comprehensive literature search was conducted across PubMed, Scopus, and ScienceDirect databases, covering publications from January 2000 to February 2025. The discussion focuses on the physicochemical characteristics, biological behavior, and relevance of these systems in the delivery of both hydrophilic and hydrophobic drugs.Expert opinion: Self-assembled drug delivery systems based on hydrophobic ascorbic acid derivatives represent a promising strategy in the field of pharmaceutical development. These platforms combine biocompatibility with functional versatility, offering enhanced membrane permeability, reduced systemic toxicity, and the potential for sustained or targeted drug release. Their suitability for oral, ophthalmic, and parenteral administration further highlights their applicability across a range of therapeutic areas, including immunological, anti-inflammatory, anti-infective, and oncological treatments.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1099-1116"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery. 纳米医学磁性脂质体：合成、表征及其在药物、基因和肽传递中的应用。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1080/17425247.2025.2506829

Cristian F Rodríguez, Paula Guzmán-Sastoque, Alan Santacruz-Belalcazar, Coryna Rodriguez, Paula Villamarin, Luis H Reyes, Juan C Cruz

{"title":"Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery.","authors":"Cristian F Rodríguez, Paula Guzmán-Sastoque, Alan Santacruz-Belalcazar, Coryna Rodriguez, Paula Villamarin, Luis H Reyes, Juan C Cruz","doi":"10.1080/17425247.2025.2506829","DOIUrl":"10.1080/17425247.2025.2506829","url":null,"abstract":"Introduction: Magnetoliposomes represent a transformative advancement in nanomedicine by integrating magnetic nanoparticles with liposomal structures, creating multifunctional delivery platforms that overcome key limitations of conventional drug carriers. These hybrid systems enable precision targeting through external magnetic fields, controlled release via magnetic hyperthermia, and real-time theranostic capabilities, offering unprecedented spatiotemporal control over therapeutic administration.Areas covered: This manuscript focused primarily on studies from 2023-2025 however, a few select older references were included to provide background and context.This review examines the fundamental design principles of Magnetoliposomes, including bilayer composition, nanoparticle integration strategies, and physicochemical properties governing their biological performance. We comprehensively assess synthesis methodologies - from traditional thin-film hydration to advanced microfluidic approaches - highlighting their impact on colloidal stability, drug encapsulation, and scaling potential. Characterization techniques essential for quality control and regulatory approval are systematically reviewed, followed by applications across oncology, gene delivery, neurology, and infectious disease treatment, supported by recent experimental evidence.Expert opinion: While magnetoliposomes show remarkable therapeutic versatility, their clinical translation requires addressing biocompatibility concerns, manufacturing scalability, and regulatory hurdles. Integration with artificial intelligence, organ-on-chip technologies, and personalized medicine approaches will likely accelerate their development toward clinical reality, potentially revolutionizing treatment paradigms for complex diseases through tailored therapeutic interventions.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1069-1098"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-drug delivery system of natural products for disease prevention and treatment. 用于疾病预防和治疗的天然产物纳米给药系统。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI: 10.1080/17425247.2025.2506830

Shanghui Gao, Jian-Rong Zhou, Kazumi Yokomizo, Jun Fang

{"title":"Nano-drug delivery system of natural products for disease prevention and treatment.","authors":"Shanghui Gao, Jian-Rong Zhou, Kazumi Yokomizo, Jun Fang","doi":"10.1080/17425247.2025.2506830","DOIUrl":"10.1080/17425247.2025.2506830","url":null,"abstract":"Introduction: Natural products, derived from plants, animals, and microorganisms, offer a wide range of pharmacological activities, including anti-infective, antifungal, anti-tumor, cholesterol-lowering, and anti-inflammatory effects. However, their clinical use is often limited by challenges such as low stability, poor bioavailability, and short half-lives. Thus, developing effective drug delivery systems for these compounds is crucial.Areas covered: This review highlights the integration of natural products with nano-drug delivery systems, focusing on recent advancements that utilize the enhanced permeability and retention (EPR) effect to improve their stability, bioavailability, and targeting. By embedding natural compounds into polymeric nanoparticles or similar nanoplatforms, these formulations significantly enhance pharmacokinetic and pharmacodynamic properties, overcoming traditional limitations.Expert opinion: Combining natural products with nanoparticle technology shows great potential to expand their therapeutic applications. Although these innovations improve the pharmacological profiles of natural compounds, continued research is essential to optimize clinical use. Advances in nanoparticle design and delivery strategies will be key to maximizing the therapeutic potential of natural products, addressing existing challenges, and enhancing their efficacy in disease treatment.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1057-1067"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations. 碳点作为纳米载体在药物传递中的作用：目前的进展、前景和实现。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-07-01 DOI: 10.1080/17425247.2025.2513439

Zeshan Ali Sandhu, Muhammad Asam Raza, Umme Farwa, Muhammad Saad Fareed, Abdulmajeed Alqurashi, Muhammad Latif

{"title":"Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations.","authors":"Zeshan Ali Sandhu, Muhammad Asam Raza, Umme Farwa, Muhammad Saad Fareed, Abdulmajeed Alqurashi, Muhammad Latif","doi":"10.1080/17425247.2025.2513439","DOIUrl":"10.1080/17425247.2025.2513439","url":null,"abstract":"Introduction: Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties.Area covered: This review presents a comprehensive overview of recent developments in CDs within the context of drug delivery systems (DDSs) and their utilization as carriers for drug loading, stabilization, and delivery. It also describes functionalized CDs for therapeutic applications, including cancer, antimicrobial, and gene therapies. Key strategic issues such as toxicity, biodistribution, and manufacturability are thoroughly elaborated and critically evaluated to identify novel approaches to address crucial challenges.Expert opinion: The promising potential of CDs to transform current drug delivery methods is driving researchers to undertake further biological investigations regarding the application of the CDs in clinical settings, as well as to explore future prospects of CDs within the biomedical field.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1171-1192"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0