Expert opinion on drug delivery最新文献_第10页

The crossroad of nanovesicles and oral delivery of insulin. 纳米囊泡与胰岛素口服给药的十字路口。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-10-30 DOI: 10.1080/17425247.2023.2266992

Mohammad Reza Fadaei, Marzieh Mohammadi, Mohammad Saleh Fadaei, Mahmoud Reza Jaafari

{"title":"The crossroad of nanovesicles and oral delivery of insulin.","authors":"Mohammad Reza Fadaei, Marzieh Mohammadi, Mohammad Saleh Fadaei, Mahmoud Reza Jaafari","doi":"10.1080/17425247.2023.2266992","DOIUrl":"10.1080/17425247.2023.2266992","url":null,"abstract":"Introduction: Diabetes mellitus is one of the challenging health problems worldwide. Multiple daily subcutaneous injection of insulin causes poor compliance in patients. Development of efficient oral formulations to improve the quality of life of such patients has been an important goal in pharmaceutical industry. However, due to serious issues such as low bioavailability and instability, it has not been achieved yet.Areas covered: Due to functional properties of the vesicles and the fact that hepatic-directed vesicles of insulin could reach the clinical phases, we focused on three main vesicular delivery systems for oral delivery of insulin: liposomes, niosomes, and polymersomes. Recent papers were thoroughly discussed to provide a broad overview of such oral delivery systems.Expert opinion: Although conventional liposomes are unstable in the presence of bile salts, their further modifications such as surface coating could increase their stability in the GI tract. Bilosomes showed good flexibility and stability in GI fluids. Also, niosomes were stable, but they could not induce significant hypoglycemia in animal studies. Although polymersomes were effective, they are expensive and there are some issues about their safety and industrial scale-up. Also, we believe that other modifications such as addition of a targeting agent or surface coating of the vesicles could significantly increase the bioavailability of insulin-loaded vesicles.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives. 基于纳米微粒作为药物递送策略的多功能系统：进展、挑战和未来展望。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-10-17 DOI: 10.1080/17425247.2023.2263360

Suzana Gonçalves Carvalho, Aline Martins Dos Santos, Amanda Letícia Polli Silvestre, Alberto Gomes Tavares, Marlus Chorilli, Maria Palmira Daflon Gremião

{"title":"Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives.","authors":"Suzana Gonçalves Carvalho, Aline Martins Dos Santos, Amanda Letícia Polli Silvestre, Alberto Gomes Tavares, Marlus Chorilli, Maria Palmira Daflon Gremião","doi":"10.1080/17425247.2023.2263360","DOIUrl":"10.1080/17425247.2023.2263360","url":null,"abstract":"Introduction: Innovative delivery systems are a promising and attractive approach for drug targeting in pharmaceutical technology. Among the various drug delivery systems studied, the association of strategies based on nanoparticles and microparticles, called nano-in-microparticles, has been gaining prominence as it allows targeting in a specific and personalized way, considering the physiological barriers faced in each disease.Areas covered: This review proposes to discuss nano-in-micro systems, updated progress on the main biomaterials used in the preparation of these systems, preparation techniques, physiological considerations, applications and challenges, and possible strategies for drug administration. Finally, we bring future perspectives for advances in clinical and field translation of multifunctional systems based on nano-in-microparticles.Expert opinion: This article brings a new approach to exploring the use of multifunctional systems based on nano-in-microparticles for different applications, in addition, it also emphasizes the use of biomaterials in these systems and their limitations. There is currently no study in the literature that explores this approach, making a review article necessary to address this association of strategies for application in pharmaceutical technology.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery. 实验设计（DoE）作为一种设计质量（QbD）工具，用于优化鼻脑给药的脂质纳米颗粒配方。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-29 DOI: 10.1080/17425247.2023.2274902

A C Correia, J N Moreira, J M Sousa Lobo, A C Silva

{"title":"Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery.","authors":"A C Correia, J N Moreira, J M Sousa Lobo, A C Silva","doi":"10.1080/17425247.2023.2274902","DOIUrl":"10.1080/17425247.2023.2274902","url":null,"abstract":"Introduction: The nose-to-brain route has been widely investigated to improve drug targeting to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles - SLN and nanostructured lipid carriers - NLC) seem promising, although they should meet specific criteria of particle size (PS) <200 nm, polydispersity index (PDI) <0.3, zeta potential (ZP) ~|20| mV and encapsulation efficiency (EE) >80%. To optimize SLN and NLC formulations, design of experiment (DoE) has been recommended as a quality by design (QbD) tool.Areas covered: This review presents recently published work on the optimization of SLN and NLC formulations for nose-to-brain drug delivery. The impact of different factors (or independent variables) on responses (or dependent variables) is critically analyzed.Expert opinion: Different DoEs have been used to optimize SLN and NLC formulations for nose-brain drug delivery, and the independent variables lipid and surfactant concentration and sonication time had the greatest impact on the dependent variables PS, EE, and PDI. Exploring different DoE approaches is important to gain a deeper understanding of the factors that affect successful optimization of SLN and NLC and to facilitate future work improving machine learning techniques.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71416345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery. 识别、设计和验证抗体靶向血脑屏障受体介导的跨细胞吞噬系统用于中枢神经系统药物递送的策略。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-29 DOI: 10.1080/17425247.2023.2286371

Eun Seo Choi, Eric V Shusta

{"title":"Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery.","authors":"Eun Seo Choi, Eric V Shusta","doi":"10.1080/17425247.2023.2286371","DOIUrl":"10.1080/17425247.2023.2286371","url":null,"abstract":"Introduction: Numerous therapeutics for neurological diseases have been developed, but many have failed in clinical trials in part due to limited brain bioavailability, mainly stemming from inefficient transport through the blood-brain barrier (BBB). One potential approach to noninvasive, BBB-targeted drug delivery to the brain is the use of engineered antibodies as delivery vehicles that can transport conjugated drug cargo across the BBB and into the brain via receptor-mediated transcytosis (RMT). Effective development of these RMT targeting systems includes novel target discovery, along with antibody engineering and subsequent validation.Areas covered: This review focuses on both known and emerging RMT systems, targeting antibody properties in relation to BBB trafficking, and antibody validation strategies.Expert opinion: Clinical development of known RMT targeting systems and identification of novel BBB RMT targets will be complementary strategies for overcoming the BBB in central nervous system (CNS) disease treatment. The search for new RMT targets with higher brain specificity and enriched expression in the brain has given rise to some new targets which may offer unique benefits. It is our opinion that the expansion of BBB RMT system identification, along with targeting molecule engineering and validation strategies, will substantially contribute to the treatment of a wide range of neurological diseases.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review. 小患者，大挑战：指导儿科药物操作以防止药物错误-全面综述。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-20 DOI: 10.1080/17425247.2023.2273838

Konstantina Chachlioutaki, Christos Gioumouxouzis, Christina Karavasili, Dimitrios G Fatouros

{"title":"Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review.","authors":"Konstantina Chachlioutaki, Christos Gioumouxouzis, Christina Karavasili, Dimitrios G Fatouros","doi":"10.1080/17425247.2023.2273838","DOIUrl":"10.1080/17425247.2023.2273838","url":null,"abstract":"Introduction: Medication errors during drug manipulations in pediatric care pose significant challenges to patient safety and optimal medication management. Epidemiological studies have revealed a high prevalenceof medication errors throughout the medication process. Due to the lack of age-appropriate dosage forms, medication manipulation is common in pediatric drug administration. The consequences of these manipulations on drug efficacy and safety could be devastating, highlighting the need for evidence-based guidelines and standardized compounding practices.Areas covered: This review focuses on examining medication errors in pediatric care and delving into the manipulation of medicinal products.Expert opinion: The observed prevalence of medication errors and manipulations underscores the importance of addressing these issues to enhance patient safety and improve medication outcomes in pediatric care. Overall, the development of age-appropriate formulations and the dissemination of comprehensive clinical guidelines are essential steps toward improving medication safety and minimizing manipulations in pediatric healthcare settings.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery. 用于主动胃肠道药物递送的生物相容性智能微/纳米机器人。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-10-30 DOI: 10.1080/17425247.2023.2270915

Baozhen Zhang, Lizhen Zhu, Hong Pan, Lintao Cai

{"title":"Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery.","authors":"Baozhen Zhang, Lizhen Zhu, Hong Pan, Lintao Cai","doi":"10.1080/17425247.2023.2270915","DOIUrl":"10.1080/17425247.2023.2270915","url":null,"abstract":"Introduction: Oral delivery is the most commonly used route of drug administration owing to good patient compliance. However, the gastrointestinal (GI) tract contains multiple physiological barriers that limit the absorption efficiency of conventional passive delivery systems resulting in a low drug concentration reaching the diseased sites. Micro/nanorobots can convert energy to self-propulsive force, providing a novel platform to actively overcome GI tract barriers for noninvasive drug delivery and treatment.Areas covered: In this review, we first describe the microenvironments and barriers in the different compartments of the GI tract. Afterward, the applications of micro/nanorobots to overcome GI tract barriers for active drug delivery are highlighted and discussed. Finally, we summarize and discuss the challenges and future prospects of micro/nanorobots for further clinical applications.Expert opinion: Micro/nanorobots with the ability to autonomously propel themselves and to load, transport, and release payloads on demand are ideal carriers for active oral drug delivery. Although there are many challenges to be addressed, micro/nanorobots have great potential to introduce a new era of drug delivery for precision therapy.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product. 在临床肉毒杆菌毒素产品的配方和性能中非典型使用含CPP的肽的技术评估。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-10-17 DOI: 10.1080/17425247.2023.2251399

Steven F Dowdy, Conor J Gallagher, Domenico Vitarella, Jessica Brown

{"title":"A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product.","authors":"Steven F Dowdy, Conor J Gallagher, Domenico Vitarella, Jessica Brown","doi":"10.1080/17425247.2023.2251399","DOIUrl":"10.1080/17425247.2023.2251399","url":null,"abstract":"Introduction: Cell-penetrating peptides (CPPs), are small peptides that facilitate cytosolic access and, thus, transport of therapeutic macromolecules to intracellular sites when conjugated to cargo proteins. As with all new delivery platforms, clinical development of CPP-containing therapeutics has faced considerable challenges.Areas covered: RTP004 is a novel, 35-amino acid, bi-CPP-containing excipient that binds noncovalently with its cargo (botulinum toxin type A) rather than conjugated as a fusion protein. An RTP004-containing neurotoxin formulation, daxibotulinumtoxinA-lanm for injection (DAXI), has recently been approved by the FDA. The formulation and pharmacological characteristics of RTP004 and the efficacy and safety of the RTP004-neurotoxin formulation are discussed.Expert opinion: RTP004 is a highly positively charged lysine- and arginine-rich structure that provides formulation stability, preventing self-aggregation of the cargo protein and adsorption to container surfaces. The presence of RTP004 in the formulation also appears to increase presynaptic binding of the neurotoxin, reduces post-injection diffusion, and thus facilitates an increase in the cleavage of the intracellular substrate for the botulinum toxin, likely through enhanced cellular uptake. The RTP004-neurotoxin formulation is the first CPP-containing product approved for clinical use. The potential for RTP004 to facilitate other therapeutic cargo molecules requires further research.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel bio-inspired microneedles for wound healing applications. 新型仿生微针用于伤口愈合应用。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-20 DOI: 10.1080/17425247.2023.2279116

Sanshita, Suman Pahal, Vivek Ghate, Inderbir Singh

引用次数: 0

Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy. 静脉注射纳米晶体：制造、固化、体内命运和癌症治疗应用。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-20 DOI: 10.1080/17425247.2023.2268512

Qing Xia, Jiaqi Shen, Huining Ding, Siyi Liu, Fei Li, Fengqian Li, Nianping Feng

{"title":"Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy.","authors":"Qing Xia, Jiaqi Shen, Huining Ding, Siyi Liu, Fei Li, Fengqian Li, Nianping Feng","doi":"10.1080/17425247.2023.2268512","DOIUrl":"10.1080/17425247.2023.2268512","url":null,"abstract":"Introduction: Intravenous nanocrystals (INCs) have shown intrinsic advantages in antitumor applications, particularly their properties of high drug loading, low toxicity, and controllable size. Therefore, it has a very bright application prospect as a drug delivery system.Areas covered: The ideal formulation design principles, fabrication, solidification, in vivo fate of INCs, the applications in drug delivery system (DDS) and the novel applications are covered in this review.Expert opinion: It is vital to select a suitable formulation and fabrication method to produce a stable and sterile INCs. Besides, the type of stabilizers and physical characteristics can also influence the in vivo fate of INCs, which is worthy of further studying. Based on wide researches about applications of INCs in cancer, biomimetic INCs are concerned increasingly for its favorable compatibility. The output of these studies suggested that INCs-based drug delivery could be a novel strategy for addressing the delivery of the drug that faces solubility, bioavailability, and toxicity problems.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral nanoparticulate drug delivery systems for the treatment of intestinal bowel disease and colorectal cancer. 用于治疗肠道疾病和结直肠癌的口服纳米颗粒给药系统。

Expert opinion on drug delivery Pub Date : 2023-07-01 Epub Date: 2023-12-20 DOI: 10.1080/17425247.2023.2289586

Flavia Laffleur, Alexander Heinz Mayer

{"title":"Oral nanoparticulate drug delivery systems for the treatment of intestinal bowel disease and colorectal cancer.","authors":"Flavia Laffleur, Alexander Heinz Mayer","doi":"10.1080/17425247.2023.2289586","DOIUrl":"10.1080/17425247.2023.2289586","url":null,"abstract":"Introduction: The most popular method for delivering drugs locally and systemically is oral. However, the gastrointestinal tract's severe physiological (mucosal and enzymatic barrier) and physicochemical (pH) environment places restrictions on the oral drug delivery system's bioavailability and targeted design.Areas covered: Various nanoparticulate drug delivery systems (NPDDSs) based on lipids or polymers, such as liposomes, solid lipid nanoparticles, polymeric micelles, nanospheres, and nanocapsules and their application in successful treatment of serious diseases such as intestinal bowel disease and colorectal cancer (CRC). These systems can ensure advantages over conventional systems liked improved bioavailability, prolonged residence time, and enhanced solubility of poorly soluble drugs. Moreover, the nature of these NPDDSs led to numerous breakthroughs in bioavailability, active and passive targeting, controlled release, and cost-efficient production on an industrial scale in recent years.Expert opinion: An expert opinion on orally administrable lipid and polymer based NPDDS, the physiological barriers and their use in the treatment of intestinal bowel disease and CRC is provided within this review.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0