Expert opinion on drug delivery最新文献_第10页

Acetalated dextran: a novel delivery platform for particle-based vaccines. 醋酸化右旋糖酐：一种新型颗粒基疫苗递送平台。

Expert opinion on drug delivery Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.1080/17425247.2024.2442671

Grace L Williamson, Denzel D Middleton, Kristy M Ainslie, Eric M Bachelder

引用次数: 0

Advancements in ultrasound-mediated drug delivery for central nervous system disorders. 超声介导给药治疗中枢神经系统疾病的研究进展。

Expert opinion on drug delivery Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1080/17425247.2024.2438188

Chi-Fen Chuang, Thi-Nhan Phan, Ching-Hsiang Fan, Thanh-Thuy Vo Le, Chih-Kuang Yeh

{"title":"Advancements in ultrasound-mediated drug delivery for central nervous system disorders.","authors":"Chi-Fen Chuang, Thi-Nhan Phan, Ching-Hsiang Fan, Thanh-Thuy Vo Le, Chih-Kuang Yeh","doi":"10.1080/17425247.2024.2438188","DOIUrl":"10.1080/17425247.2024.2438188","url":null,"abstract":"Introduction: Central nervous system (CNS) disorders present major therapeutic challenges due to the presence of the blood - brain barrier (BBB) and disease heterogeneity. The BBB impedes most therapeutic agents, which restricts conventional treatments. Focused ultrasound (FUS) -assisted delivery offers a novel solution by temporarily disrupting the BBB and thereby enhancing drug delivery to the CNS.Areas covered: This review outlines the fundamental principles of FUS-assisted drug delivery technology, with an emphasis on its role in enhancing the spatial precision of therapeutic interventions and its molecular effects on the cellular composition of the BBB. Recent promising clinical studies are surveyed, and a comparative analysis of current US-assisted delivery system is provided. Additionally, the latest advancements and challenges of this technology are discussed.Expert opinion: FUS-mediated drug delivery shows promise, but the clinical translation of research findings is challenging. Key issues include safety, dosage optimization, and balancing efficacy with the risk of tissue damage. Continued research is crucial to address these challenges and bridge the gap between preclinical and clinical applications, and could transform treatments of CNS disorders.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"15-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery. 牛血清白蛋白纳米颗粒：一个有前途的鼻腔给药平台。

Expert opinion on drug delivery Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1080/17425247.2024.2436117

Sandra Aulia Mardikasari, Gábor Katona, Ildikó Csóka

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Artificial intelligence for personalized nanomedicine; from material selection to patient outcomes. 个性化纳米医学的人工智能；从材料选择到患者结果。

Expert opinion on drug delivery Pub Date : 2025-01-01 Epub Date: 2024-12-15 DOI: 10.1080/17425247.2024.2440618

Hirak Mazumdar, Kamil Reza Khondakar, Suparna Das, Animesh Halder, Ajeet Kaushik

{"title":"Artificial intelligence for personalized nanomedicine; from material selection to patient outcomes.","authors":"Hirak Mazumdar, Kamil Reza Khondakar, Suparna Das, Animesh Halder, Ajeet Kaushik","doi":"10.1080/17425247.2024.2440618","DOIUrl":"10.1080/17425247.2024.2440618","url":null,"abstract":"Introduction: Artificial intelligence (AI) is changing the field of nanomedicine by exploring novel nanomaterials for developing therapies of high efficacy. AI works on larger datasets, finding sought-after nano-properties for different therapeutic aims and eventually enhancing nanomaterials' safety and effectiveness. AI leverages patient clinical and genetic data to predict outcomes, guide treatments, and optimize drug dosages and forms, enhancing benefits while minimizing side effects. AI-supported nanomedicine faces challenges like data fusion, ethics, and regulation, requiring better tools and interdisciplinary collaboration. This review highlights the importance of AI regarding patient care and urges scientists, medical professionals, and regulators to adopt AI for better outcomes.Areas covered: Personalized Nanomedicine, Material Discovery, AI-Driven Therapeutics, Data Integration, Drug Delivery, Patient Centric Care.Expert opinion: Today, AI can improve personalized health wellness through the discovery of new types of drug nanocarriers, nanomedicine of specific properties to tackle targeted medical needs, and an increment in efficacy along with safety. Nevertheless, problems such as ethical issues, data security, or unbalanced data sets need to be addressed. Potential future developments involve using AI and quantum computing together and exploring telemedicine i.e. the Internet-of-Medical-Things (IoMT) approach can enhance the quality of patient care in a personalized manner by timely decision-making.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"85-108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery? 刺激反应型杂化共聚物纳米颗粒是肿瘤药物输送的下一个创新吗？

Expert opinion on drug delivery Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1080/17425247.2024.2436081

Martin Hrubý

引用次数: 0

Nanomedicines modulate the tumor immune microenvironment for cancer therapy. 纳米药物调节肿瘤免疫微环境以治疗癌症。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI: 10.1080/17425247.2024.2412245

Po-Han Chao, Vanessa Chan, Shyh-Dar Li

{"title":"Nanomedicines modulate the tumor immune microenvironment for cancer therapy.","authors":"Po-Han Chao, Vanessa Chan, Shyh-Dar Li","doi":"10.1080/17425247.2024.2412245","DOIUrl":"10.1080/17425247.2024.2412245","url":null,"abstract":"Introduction: In recent years, the evolution of immunotherapy as a means to trigger a robust antitumor immune response has revolutionized cancer treatment. Despite its potential, the effectiveness of cancer immunotherapy is hindered by low response rates and significant systemic side effects. Nanotechnology emerges as a promising frontier in shaping the future of cancer immunotherapy.Areas covered: This review elucidates the pivotal role of nanomedicine in reshaping the immune tumor microenvironment and explores innovative strategies pursued by diverse research groups to enhance the therapeutic efficacy of cancer immunotherapy. It discusses the hurdles encountered in cancer immunotherapy and the application of nanomedicine for small molecule immune modulators and nucleic acid therapeutics. It also highlights the advancements in DNA and mRNA vaccines facilitated by nanotechnology and outlines future trajectories in this evolving field.Expert opinion: Collectively, the integration of nanomedicine into cancer immunotherapy stands as a promising avenue to tackle the intricacies of the immune tumor microenvironment. Innovations such as immune checkpoint inhibitors and cancer vaccines have shown promise. Future developments will likely optimize nanoparticle design through artificial intelligence and create biocompatible, multifunctional nanoparticles, promising more effective, personalized, and durable cancer treatments, potentially transforming the field in the foreseeable future.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1719-1733"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of nanosystems in disrupting adenosine signaling pathways for tumor immunotherapy. 纳米系统在破坏腺苷信号通路促进肿瘤免疫疗法方面的潜力。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1080/17425247.2024.2417687

Yutong Zhao, Jingqi Sun, Xiao-Ling Xu, Jin Su, Yong-Zhong Du

引用次数: 0

Future clinical potential of leukocyte-mimicking nanoparticles. 仿白细胞纳米粒子的未来临床潜力。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-11-17 DOI: 10.1080/17425247.2024.2430389

Francesca Taraballi

引用次数: 0

An opinion on advanced cancer immunotherapy through innovations in PD-1 inhibitor delivery systems. 通过 PD-1 抑制剂给药系统的创新实现先进的癌症免疫疗法。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1080/17425247.2024.2428623

Piyush Kumar Gupta, Harshita Tiwari, Richa Mishra, Kalpana Balakrishnan, Shikha Singh, Sandeep Kumar, Kavindra Kumar Kesari, Saravanan Krishnan

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Ocular delivery of Amphotericin B: current challenges and future perspectives. 两性霉素 B 的眼部给药：当前挑战与未来展望。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-27 DOI: 10.1080/17425247.2024.2420750

Velmurugan Kailasam, Samhita Sai Veda Koduganti, Oindrilla Dasgupta, Prashant Garg, Jayabalan Nirmal

{"title":"Ocular delivery of Amphotericin B: current challenges and future perspectives.","authors":"Velmurugan Kailasam, Samhita Sai Veda Koduganti, Oindrilla Dasgupta, Prashant Garg, Jayabalan Nirmal","doi":"10.1080/17425247.2024.2420750","DOIUrl":"10.1080/17425247.2024.2420750","url":null,"abstract":"Introduction: Amphotericin B is a polyene antibiotic that is used as an off-label eye drop to treat fungal keratitis. Poor solubility, permeability and high susceptibility to hydrolytic degradation make it challenging to formulate a drug delivery system. Despite its drawbacks, it is a potent antifungal drug against Candida and other fungal species. However, it has not been explored much in ocular drug delivery. Hence, this review brings into focus the potential and increasing significance of Amphotericin B in ocular drug delivery.Areas covered: In this review, we have systematically summarized the use of Amphotericin B in ocular diseases, the various formulation challenges for Amphotericin B, along with its off-label ocular usage, and stability concerns. The degradation mechanism of Amphotericin B in different conditions was discussed in this article as well.Expert opinion: In the last few decades, several nanocarriers have been explored to improve the formulation challenges associated with Amphotericin B. Also, due to insufficient clinical studies and unknown toxicity profile, there is no US Food and Drug Administration (FDA) approved Amphotericin B formulation for ocular drug delivery. This review aims to offer thorough information about Amphotericin B in ocular drug delivery.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1793-1805"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0