Expert opinion on drug delivery最新文献_第9页

Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements. 用设计元件组装的控释渗透给药系统的微细加工。

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI: 10.1080/17425247.2024.2412826

Bence Borbás, Nikolett Kállai-Szabó, Miléna Lengyel, Emese Balogh, Bálint Basa, Károly Süvegh, Romána Zelkó, István Antal

{"title":"Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements.","authors":"Bence Borbás, Nikolett Kállai-Szabó, Miléna Lengyel, Emese Balogh, Bálint Basa, Károly Süvegh, Romána Zelkó, István Antal","doi":"10.1080/17425247.2024.2412826","DOIUrl":"10.1080/17425247.2024.2412826","url":null,"abstract":"Background: This study investigates combining 3D printing with traditional compression methods to develop a multicomponent, controlled-release drug delivery system (DDS). The system uses osmotic tablet layers and a semipermeable membrane to control drug release, similar to modular Lego® structures.Methods: The DDS comprises two directly compressed tablet layers (push and pull) and a semipermeable membrane, all contained within a 3D-printed frame. The membrane is made from cellulose acetate and plasticizers like glycerol and propylene glycol. Various characterization techniques, including Positron Annihilation Lifetime Spectroscopy (PALS), were employed to evaluate microstructural properties, wettability, morphology, and drug dissolution.Results: Glycerol improved the membrane's wettability, as confirmed by PALS. The system achieved zero-order drug release, unaffected by stirring rates, due to the push and pull tablets within the 3D-printed frame. The release profile was stable, demonstrating effective drug delivery control.Conclusion: The study successfully developed a prototype for a controlled-release osmotic DDS, achieving zero-order release kinetics for quinine hydrochloride after 2 h. This modular approach holds potential for personalized therapies in human and veterinary medicine, allowing customization at the point of care.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1637-1649"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of the application of 3D-bioprinting in chronic wound management. 全面回顾三维生物打印技术在慢性伤口管理中的应用。

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-06-25 DOI: 10.1080/17425247.2024.2355184

Prathap Madeswara Guptha, Jovita Kanoujia, Ankita Kishore, Neha Raina, Abhishek Wahi, Piyush Kumar Gupta, Madhu Gupta

{"title":"A comprehensive review of the application of 3D-bioprinting in chronic wound management.","authors":"Prathap Madeswara Guptha, Jovita Kanoujia, Ankita Kishore, Neha Raina, Abhishek Wahi, Piyush Kumar Gupta, Madhu Gupta","doi":"10.1080/17425247.2024.2355184","DOIUrl":"10.1080/17425247.2024.2355184","url":null,"abstract":"Introduction: Chronic wounds require more sophisticated care than standard wound care because they are becoming more severe as a result of diseases like diabetes. By resolving shortcomings in existing methods, 3D-bioprinting offers a viable path toward personalized, mechanically strong, and cell-stimulating wound dressings.Areas covered: This review highlights the drawbacks of traditional approaches while navigating the difficulties of managing chronic wounds. The conversation revolves around employing natural biomaterials for customized dressings, with a particular emphasis on 3D-bioprinting. A thorough understanding of the uses of 3D-printed dressings in a range of chronic wound scenarios is provided by insights into recent research and patents.Expert opinion: The expert view recognizes wounds as a historical human ailment and emphasizes the growing difficulties and expenses related to wound treatment. The expert acknowledges that 3D printing is revolutionary, but also points out that it is still in its infancy and has the potential to enhance mass production rather than replace it. The review highlights the benefits of 3D printing for wound dressings by providing instances of smart materials that improve treatment results by stimulating angiogenesis, reducing pain, and targeting particular enzymes. The expert advises taking action to convert the technology's prospective advantages into real benefits for patients, even in the face of resistance to change in the healthcare industry. It is believed that the increasing evidence from in-vivo studies is promising and represents a positive change in the treatment of chronic wounds toward sophisticated 3D-printed dressings.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1573-1594"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed dosage forms, where are we headed? 3D 打印剂型，我们将何去何从？

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-07-24 DOI: 10.1080/17425247.2024.2379943

Ishwor Poudel, Nur Mita, R Jayachandra Babu

{"title":"3D printed dosage forms, where are we headed?","authors":"Ishwor Poudel, Nur Mita, R Jayachandra Babu","doi":"10.1080/17425247.2024.2379943","DOIUrl":"10.1080/17425247.2024.2379943","url":null,"abstract":"Introduction: 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact of 3DP in drug product development. Almost 8 years after the first USFDA approval of the 3D printed tablet Levetiracetam (Spritam), the interest in 3DP for drug products is high. However, regulatory agencies have often questioned its large-scale industrial practicability, and 3DP drug approval/guidelines are yet to be streamlined.Areas covered: In this review, major technologies involved with the fabrication of drug products are introduced along with the prospects of upcoming technologies, including AI (Artificial Intelligence). We have touched upon regulatory updates and discussed the burning limitations, which require immediate focus, illuminating status, and future perspectives on the near future of 3DP in the pharmaceutical field.Expert opinion: 3DP offers significant advantages in rapid prototyping for drug products, which could be beneficial for personalizing patient-based pharmaceutical dispensing. It seems inevitable that the coming decades will be marked by exponential growth in personalization, and 3DP could be a paradigm-shifting asset for pharmaceutical professionals.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1595-1614"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management. 生物聚合物三维打印植入式支架作为急性术后疼痛治疗的潜在辅助疗法。

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-03-30 DOI: 10.1080/17425247.2024.2336492

Aikaterini Dedeloudi, Laura Martinez-Marcos, Thomas Quinten, Sune Andersen, Dimitrios A Lamprou

{"title":"Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management.","authors":"Aikaterini Dedeloudi, Laura Martinez-Marcos, Thomas Quinten, Sune Andersen, Dimitrios A Lamprou","doi":"10.1080/17425247.2024.2336492","DOIUrl":"10.1080/17425247.2024.2336492","url":null,"abstract":"Background: Pain is characterized as a major symptom induced by tissue damage occurring from surgical procedures, whose potency is being experienced subjectively, while current pain relief strategies are not always efficient in providing individualized treatment. 3D printed implantable devices hold the potential to offer a precise and customized medicinal approach, targeting both tissue engineering and drug delivery.Research design and methods: Polycaprolactone (PCL) and PCL - chitosan (CS) composite scaffolds loaded with procaine (PRC) were fabricated by bioprinting. Geometrical features including dimensions, pattern, and infill of the scaffolds were mathematically optimized and digitally determined, aiming at developing structurally uniform 3D printed models. Printability studies based on thermal imaging of the bioprinting system were performed, and physicochemical, surface, and mechanical attributes of the extruded scaffolds were evaluated. The release rate of PRC was examined at different time intervals up to 1 week.Results: Physicochemical stability and mechanical integrity of the scaffolds were studied, while in vitro drug release studies revealed that CS contributes to the sustained release dynamic of PRC.Conclusions: The printing extrusion process was capable of developing implantable devices for a local and sustained delivery of PRC as a 7-day adjuvant regimen in post-operative pain management.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1651-1663"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering. 组织工程中药物输送支架的三维打印和计算机辅助设计技术。

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1080/17425247.2024.2409913

Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib, Navid Rabiee

{"title":"3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering.","authors":"Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib, Navid Rabiee","doi":"10.1080/17425247.2024.2409913","DOIUrl":"10.1080/17425247.2024.2409913","url":null,"abstract":"Introduction: The challenge in tissue engineering lies in replicating the intricate structure of the native extracellular matrix. Recent advancements in AM, notably 3D printing, offer unprecedented capabilities to tailor scaffolds precisely, controlling properties like structure and bioactivity. CAD tools complement this by facilitating design using patient-specific data.Area’s covered: This review introduces additive manufacturing (AM) and computer-aided design (CAD) as pivotal tools in advancing tissue engineering, particularly cartilage regeneration. This article explores various materials utilized in AM, focusing on polymers and hydrogels for their advantageous properties in tissue engineering applications. Integrating bioactive molecules, including growth factors, into scaffolds to promote tissue regeneration is discussed alongside strategies involving different cell sources, such as stem cells, to enhance tissue development within scaffold matrices.Expert opinion: Applications of AM and CAD in addressing specific challenges like osteochondral defects and osteoarthritis in cartilage tissue engineering are highlighted. This review consolidates current research findings, offering expert insights into the evolving landscape of AM and CAD technologies in advancing tissue engineering, particularly in cartilage regeneration.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1615-1636"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D bioprinted microneedles: merging drug delivery and scaffold science for tissue-specific applications. 三维生物打印微针：融合给药和支架科学，实现组织特异性应用。

Expert opinion on drug delivery Pub Date : 2024-11-01 Epub Date: 2024-05-09 DOI: 10.1080/17425247.2024.2351928

Mershen Govender, Sunaina Indermun, Yahya E Choonara

{"title":"3D bioprinted microneedles: merging drug delivery and scaffold science for tissue-specific applications.","authors":"Mershen Govender, Sunaina Indermun, Yahya E Choonara","doi":"10.1080/17425247.2024.2351928","DOIUrl":"10.1080/17425247.2024.2351928","url":null,"abstract":"Introduction: Three-Dimensional (3D) microneedles have recently gained significant attention due to their versatility, biocompatibility, enhanced permeation, and predictable behavior. The incorporation of biological agents into these 3D constructs has advanced the traditional microneedle into an effective platform for wide-ranging applications.Areas covered: This review discusses the current state of microneedle fabrication as well as the developed 3D printed microneedles incorporating labile pharmaceutical agents and biological materials for potential biomedical applications. The mechanical and processing considerations for the preparation of microneedles and the barriers to effective 3D printing of microneedle constructs have additionally been reviewed along with their therapeutic applications and potential for tissue engineering and regenerative applications. Additionally, the regulatory considerations for microneedle approval have been discussed as well as the current clinical trial and patent landscapes.Expert opinion: The fields of tissue engineering and regenerative medicine are evolving at a significant pace with researchers constantly focused on incorporating advanced manufacturing techniques for the development of versatile, complex, and biologically specific platforms. 3D bioprinted microneedles, fabricated using conventional 3D printing techniques, have resultantly provided an alternative to 2D bioscaffolds through the incorporation of biological materials within 3D constructs while providing further mechanical stability, increased bioactive permeation and improved innervation into surrounding tissues. This advancement therefore potentially allows for a more effective biomimetic construct with improved tissue-specific cellular growth for the enhanced treatment of physiological conditions requiring tissue regeneration and replacement.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1559-1572"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving antifungal lipid-based drug delivery against Candida: a review. 改进以脂质为基础的抗真菌药物输送以对抗念珠菌：综述。

Expert opinion on drug delivery Pub Date : 2024-10-29 DOI: 10.1080/17425247.2024.2421402

Gabriel Davi Marena, Alba Ruiz-Gaitán, Taís Maria Bauab, Marlus Chorilli

{"title":"Improving antifungal lipid-based drug delivery against Candida: a review.","authors":"Gabriel Davi Marena, Alba Ruiz-Gaitán, Taís Maria Bauab, Marlus Chorilli","doi":"10.1080/17425247.2024.2421402","DOIUrl":"10.1080/17425247.2024.2421402","url":null,"abstract":"Introduction: Fungal infections, particularly those caused by Candida spp. have increased in recent years. A primary contributor to this surge was the COVID-19 pandemic, where many hospitalized patients had secondary fungal infections. Additionally, the emergence of resistant and multi-resistant fungal strains has become increasingly problematic due to the limited therapeutic options available in antifungal treatments.Areas covered: This review presents a comprehensive analysis of recent studies focused on the development and characterization of lipid-based nanosystems as an emerging and promising therapeutic alternative. These systems have been evaluated for their potential to deliver antifungal agents specifically targeting resistant Candida spp. strains, offering a controlled and sustained release of drugs.Expert opinion: Lipid-based nanomaterials are promising tools for the controlled and sustained release of drugs, particularly in treating Candida spp. infections. Although substantial research has been dedicated to development of these nanomaterials, only a few have reached clinical application, such as liposomal amphotericin B, for example. Therefore, it is critical to push forward with advancements to bring these nanomedicines into clinical practice, where they can contribute meaningfully to mitigating the challenge of resistant and lethal fungal strains.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study. 了解屏蔽触发式自动注射器与皮肤之间的相互作用力：一项深入的无创研究。

Expert opinion on drug delivery Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1080/17425247.2024.2411435

Anne-Sofie Madsen Staples, Hanaa Abuo-Chalih, Dan Nørtoft Sørensen

{"title":"Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study.","authors":"Anne-Sofie Madsen Staples, Hanaa Abuo-Chalih, Dan Nørtoft Sørensen","doi":"10.1080/17425247.2024.2411435","DOIUrl":"10.1080/17425247.2024.2411435","url":null,"abstract":"Objective: This noninvasive study aimed to understand the interaction between shield-triggered autoinjectors (AI) and skin at the point of activation, hypothesizing that the AI's housing absorbs a significant amount of the user-applied force depending on shield design and skin characteristics.Methods: Twenty-seven volunteers used a test device measuring applied force versus shield force and indentation depth relative to shield length (2,4,6,8 mm) in standing and sitting positions.Results: Significant differences were found between applied and shield force for the different shield lengths. Shorter shields resulted in significantly lower force transfer coefficients, with means ranging from 0.72 for the 2 mm shield to 0.94 for the 8 mm shield. ANOVA revealed statistically significant factors (p < .05), including position and gender, with females generally having lower coefficient values. Indentation depth increased with higher forces and varied significantly between positions without significant shield length impact.Conclusion: The findings confirm that an increase in shield length at the point of activation reduces skin friction with the housing, resulting in less force loss and a lower device activation force perceived by the user. Force loss can be further reduced by standing up. Understanding device-tissue interactions will support development of better AIs with fewer user failures.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1501-1511"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development. 评估在脂质纳米颗粒中输送的核酸类有效载荷的广度，以确定开发过程中的根本差异。

Expert opinion on drug delivery Pub Date : 2024-10-01 Epub Date: 2024-10-16 DOI: 10.1080/17425247.2024.2409142

Jinjin Li, Camilla Foged

{"title":"Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development.","authors":"Jinjin Li, Camilla Foged","doi":"10.1080/17425247.2024.2409142","DOIUrl":"https://doi.org/10.1080/17425247.2024.2409142","url":null,"abstract":"Introduction: Nucleic acid (NA)-based therapeutics have shown great potential for downregulating or augmenting gene expression, and for promising applications, e.g., protein-replacement therapy and vaccination, a comprehensive understanding of the requirements for their targeted delivery to specific tissues or cells is needed.Areas covered: In this review, we discuss clinical applications of four representative types of NA-based therapeutics, i.e. antisense oligonucleotides, small interfering RNA, messenger RNA, and circular RNA, with a focus on the lipid nanoparticle (LNP) technology used for intracellular delivery. The in vivo fate of LNPs is discussed to improve the understanding of trafficking of nanomedicines at the systemic and cellular levels. In addition, NA-based vaccines are discussed, focusing on targeting antigen-presenting cells and immune activation.Expert opinion: Optimization of delivery systems for NA-based therapeutics is mainly focused on the standard requirements of prolonged systemic circulation and enhancing endosomal escape. Depending on the final destination in specific target tissues or cells, strategies should be adjusted to achieve the desired biodistribution of NA-based payloads. More studies relating to the pharmacokinetics of both cargo and carrier are encouraged, because their in vivo fates may differ, considering the possibility of premature cargo release before reaching the target.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":"21 10","pages":"1441-1461"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I - composition and production methods. 用于输送植物生物活性物质的固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）：第一部分--成分和生产方法。

Expert opinion on drug delivery Pub Date : 2024-10-01 Epub Date: 2024-10-07 DOI: 10.1080/17425247.2024.2410951

Faezeh Fathi, Tatiane O X Machado, Helena de A C Kodel, Isabella Portugal, Inês O Ferreira, Aleksandra Zielinska, M Beatriz P P Oliveira, Eliana B Souto

{"title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I - composition and production methods.","authors":"Faezeh Fathi, Tatiane O X Machado, Helena de A C Kodel, Isabella Portugal, Inês O Ferreira, Aleksandra Zielinska, M Beatriz P P Oliveira, Eliana B Souto","doi":"10.1080/17425247.2024.2410951","DOIUrl":"10.1080/17425247.2024.2410951","url":null,"abstract":"Introduction: Nanoparticles (NPs) are widely used in the pharmaceutical field to treat various human disorders. Among these, lipid-based NPs (LNPs), including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), are favored for drug/bioactive delivery due to their high stability, biocompatibility, encapsulation efficiency, and sustained/controlled release. These properties make them particularly suitable as carriers of compounds derived from plant sources.Areas covered: This study comprehensively explores updated literature knowledge on SLN and NLC, focusing on their composition and production methods for the specific delivery of drug/bioactive compounds derived from plant sources of interest in pharmaceutical and biomedical fields.Expert opinion: SLN and NLC facilitate the development of more effective natural product-based therapies, aiming to reduce dosage and minimize side effects. These delivery systems align with the consumer demands for safer and more sustainable products, as there are also based on biocompatible and biodegradable raw materials, thereby posing minimal toxicological risks while also meeting regulatory guidelines.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1479-1490"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0