Expert opinion on drug delivery最新文献_第9页

Healing with herbs: an alliance with 'nano' for wound management. 用草药治疗：与 "纳米 "结盟进行伤口管理。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1080/17425247.2024.2388214

Preksha Vinchhi, Wong Tin Wui, Mayur M Patel

{"title":"Healing with herbs: an alliance with 'nano' for wound management.","authors":"Preksha Vinchhi, Wong Tin Wui, Mayur M Patel","doi":"10.1080/17425247.2024.2388214","DOIUrl":"10.1080/17425247.2024.2388214","url":null,"abstract":"Introduction: Wound healing is an intricate and continual process influenced by numerous factors that necessitate suitable environments to attain healing. The natural ability of wound healing often gets altered by several external and intrinsic factors, leading to chronic wound occurrence. Numerous wound dressings have been developed; however, the currently available alternatives fail to coalesce in all conditions obligatory for rapid skin regeneration.Area covered: An extensive review of articles on herbal nano-composite wound dressings was conducted using PubMed, Scopus, and Google Scholar databases, from 2006 to 2024. This review entails the pathophysiology and factors leading to non-healing wounds, wound dressing types, the role of herbal bio-actives for wound healing, and the advantages of employing nanotechnology to deliver herbal actives. Numerous nano-composite wound dressings incorporated with phytoconstituents, herbal extracts, and essential oils are discussed.Expert opinion: There is a strong substantiation that several herbal bio-actives possess anti-inflammatory, antimicrobial, antioxidant, analgesic, and angiogenesis promoter activities that accelerate the wound healing process. Nanotechnology is a promising strategy to deliver herbal bio-actives as it ascertains their controlled release, enhances bioavailability, improves permeability to underlying skin layers, and promotes wound healing. A combination of herbal actives and nano-based dressings offers a novel arena for wound management.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1115-1141"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141880020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing. 关于辅料特性在从药粉到片剂的连续生产中的作用的重要评论。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1080/17425247.2024.2384698

Pauline H M Janssen, Sara Fathollahi, Bastiaan H J Dickhoff, Henderik W Frijlink

{"title":"Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing.","authors":"Pauline H M Janssen, Sara Fathollahi, Bastiaan H J Dickhoff, Henderik W Frijlink","doi":"10.1080/17425247.2024.2384698","DOIUrl":"10.1080/17425247.2024.2384698","url":null,"abstract":"Introduction: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted by the properties of the raw materials. Existing knowledge on the role of raw material properties in batch processing is however not directly transferable to continuous processes, due to the inherent differences between batch and continuous processes.Areas covered: A review is performed to evaluate the role of excipient properties for different unit operations used in continuous manufacturing processes. Unit operations that will be discussed include feeding, blending, granulation, final blending, and compression.Expert opinion: Although the potency of continuous manufacturing is widely recognized, full utilization still requires a number of challenges to be addressed effectively. An expert opinion will be provided that discusses those challenges and potential solutions to overcome those challenges. The provided overview can serve as a framework for the pharmaceutical industry to push ahead process optimization and formulation development for continuous manufacturing processes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1069-1079"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dos and don'ts to optimize transnasal aerosol drug delivery in clinical practice. 在临床实践中优化经鼻气溶胶给药的注意事项。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1080/17425247.2024.2388838

Arzu Ari, Jordan A Hoops, Ayfer Koyuncu, James B Fink

{"title":"Dos and don'ts to optimize transnasal aerosol drug delivery in clinical practice.","authors":"Arzu Ari, Jordan A Hoops, Ayfer Koyuncu, James B Fink","doi":"10.1080/17425247.2024.2388838","DOIUrl":"10.1080/17425247.2024.2388838","url":null,"abstract":"Introduction: Transnasal aerosol drug delivery has become widely accepted for treating acutely ill infants, children, and adults. More recently aerosol administration to wider populations receiving high and low-flow nasal oxygen has become common practice.Areas covered: Skepticism of insufficient aerosol delivery to the lungs has been tempered by multiple in vitro explorations of variables to optimize delivery efficiency. Additionally, clinical studies demonstrated comparable clinical responses to orally inhaled aerosols. This paper provides essential clinical guidance on how to improve transnasal aerosol delivery based on device-, settings-, and drug-related optimization to serve as a resource for educational initiatives and quality enhancement endeavors at healthcare institutions.Expert opinion: Transnasal aerosol delivery is proliferating worldwide, but indiscriminate use of excessive-high flows, poor selection and placement of aerosol devices and circuits can greatly reduce aerosol delivery and efficacy, potentially compromising treatment to acute and critically ill patients. Attention to these details can improve inhaled dose by an order of magnitude, making the difference between effective treatment and the progression to more invasive ventilatory support, with greater inherent risk and cost. These revelations have prompted specific recommendations for optimal delivery, driving advancements in aerosol generators, formulations, and future device designs to administer aerosols and maximize treatment effectiveness.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1103-1114"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract. 气道微生物群对局部和全身疾病的作用：向呼吸道输送益生菌的理由。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-07-23 DOI: 10.1080/17425247.2024.2380334

Stefania Glieca, Eride Quarta, Benedetta Bottari, Vivek C Lal, Fabio Sonvico, Francesca Buttini

{"title":"The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract.","authors":"Stefania Glieca, Eride Quarta, Benedetta Bottari, Vivek C Lal, Fabio Sonvico, Francesca Buttini","doi":"10.1080/17425247.2024.2380334","DOIUrl":"10.1080/17425247.2024.2380334","url":null,"abstract":"Introduction: Recent discoveries in the field of lung microbiota have enabled the investigation of new therapeutic interventions involving the use of inhaled probiotics.Areas covered: This review provides an overview of what is known about the correlation between airway dysbiosis and the development of local and systemic diseases, and how this knowledge can be exploited for therapeutic interventions. In particular, the review focused on attempts to formulate probiotics that can be deposited directly on the airways.Expert opinion: Despite considerable progress since the emergence of respiratory microbiota restoration as a new research field, numerous clinical implications and benefits remain to be determined. In the case of local diseases, once the pathophysiology is understood, manipulating the lung microbiota through probiotic administration is an approach that can be exploited. In contrast, the effect of pulmonary dysbiosis on systemic diseases remains to be clarified; however, this approach could represent a turning point in their treatment.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"991-1005"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gemini surfactants as next-generation drug carriers in cancer management. 双子表面活性剂是治疗癌症的新一代药物载体。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-07-26 DOI: 10.1080/17425247.2024.2384037

Oly Katari, Keshav Kumar, Shrushti Bhamble, Sanyog Jain

{"title":"Gemini surfactants as next-generation drug carriers in cancer management.","authors":"Oly Katari, Keshav Kumar, Shrushti Bhamble, Sanyog Jain","doi":"10.1080/17425247.2024.2384037","DOIUrl":"10.1080/17425247.2024.2384037","url":null,"abstract":"Introduction: Gemini surfactants (GS) are an elite class of amphiphilic molecules that have shown up as a potential candidate in the field of drug delivery because of their exceptional physicochemical properties. They comprise two hydrophilic headgroups connected by an adaptable spacer and hydrophobic tails that has shown promising results in delivering different therapeutic agents to cancer cells at preclinical level. However further studies are in demand to unlock the full potential of GS in this field.Areas covered: This review summarizes the new advancements in GS as drug carriers in cancer therapy, their capacity to overcome conventional shortcomings and the demand for innovative approaches in disease treatment. A detailed list of GS-based formulations along with a brief description on oligomeric surfactants have also been provided in this review. This article summarizes data from studies identified through literature database searches including PubMed and Google Scholar (2010-2023).Expert opinion: There are major challenges that need to be addressed in this field which restrict their progression toward clinical phase. Further research can focus on developing a theranostic system that can provide simultaneous real-time monitoring along with treatment care. Nevertheless, ensuring the safety parameters of these nanocarriers followed by their regulatory approval is a time-consuming and expensive process. A collaborative approach between regulatory bodies, research institutions, and pharmaceutical companies can speed up the process in the upcoming years.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1029-1051"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additive manufacturing of microneedles for sensing and drug delivery. 用于传感和给药的微针的快速成型制造。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-07-26 DOI: 10.1080/17425247.2024.2384696

Tuba Bedir, Sachin Kadian, Shubhangi Shukla, Oguzhan Gunduz, Roger Narayan

{"title":"Additive manufacturing of microneedles for sensing and drug delivery.","authors":"Tuba Bedir, Sachin Kadian, Shubhangi Shukla, Oguzhan Gunduz, Roger Narayan","doi":"10.1080/17425247.2024.2384696","DOIUrl":"10.1080/17425247.2024.2384696","url":null,"abstract":"Introduction: Microneedles (MNs) are miniaturized, painless, and minimally invasive platforms that have attracted significant attention over recent decades across multiple fields, such as drug delivery, disease monitoring, disease diagnosis, and cosmetics. Several manufacturing methods have been employed to create MNs; however, these approaches come with drawbacks related to complicated, costly, and time-consuming fabrication processes. In this context, employing additive manufacturing (AM) technology for MN fabrication allows for the quick production of intricate MN prototypes with exceptional precision, providing the flexibility to customize MNs according to the desired shape and dimensions. Furthermore, AM demonstrates significant promise in the fabrication of sophisticated transdermal drug delivery systems and medical devices through the integration of MNs with various technologies.Areas covered: This review offers an extensive overview of various AM technologies with great potential for the fabrication of MNs. Different types of MNs and the materials utilized in their fabrication are also discussed. Recent applications of 3D-printed MNs in the fields of transdermal drug delivery and biosensing are highlighted.Expert opinion: This review also mentions the critical obstacles, including drug loading, biocompatibility, and regulatory requirements, which must be resolved to enable the mass-scale adoption of AM methods for MN production, and future trends.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1053-1068"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities. 生物材料辅助癌症疫苗递送：临床前情况、挑战和机遇。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-17 DOI: 10.1080/17425247.2024.2388832

Minglong Chen, Yue Zhou, Yanping Fu, Qingqing Wang, Chuanbin Wu, Xin Pan, Guilan Quan

引用次数: 0

Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate. 纳米载体嵌入溶解微针的时空命运：针头溶解速度的影响。

Expert opinion on drug delivery Pub Date : 2024-06-01 Epub Date: 2024-07-08 DOI: 10.1080/17425247.2024.2375385

Jinghang Cong, Ziyang Zheng, Yanping Fu, Ziyao Chang, Chuangxin Chen, Chuanbin Wu, Xin Pan, Zhengwei Huang, Guilan Quan

{"title":"Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate.","authors":"Jinghang Cong, Ziyang Zheng, Yanping Fu, Ziyao Chang, Chuangxin Chen, Chuanbin Wu, Xin Pan, Zhengwei Huang, Guilan Quan","doi":"10.1080/17425247.2024.2375385","DOIUrl":"10.1080/17425247.2024.2375385","url":null,"abstract":"Objective: Dissolving microneedles (DMNs) have shown great potential for transdermal drug delivery due to their excellent skin-penetrating ability and combination with nanocarriers (NCs) can realize targeted drug delivery. The objective of this study was to investigate the impact of microneedle dissolving rate on the in vivo fate of NC-loaded DMNs, which would facilitate the clinical translation of such systems.Methods: Solid lipid nanoparticles (SLNs) were selected as the model NC for loading in DMNs, which were labeled by P4 probes with aggregation-quenching properties. Sodium hyaluronate acid (HA) and chitosan (CS), with different aqueous dissolving rates, were chosen as model tip materials. The effects of needle dissolving rate on the in vivo fate of NC-loaded DMNs was investigated by tracking the distribution of fluorescence signals after transdermal exposure.Results: P4 SLNs achieved a deeper diffusion depth of 180 μm in DMN-HA with a faster dissolution rate, while the diffusion depth in DMN-CS with a slower dissolution rate was lower (140 μm). The in vivo experiments demonstrated that P4 SLNs had a T1/2 value of 12.14 h in DMN-HA, whilst a longer retention time was found in DMN-CS, with a T1/2 of 13.12 h.Conclusions: This study confirmed that the in vivo diffusion rate of NC-loaded DMNs was determined by the dissolving rate of DMNs materials and provided valuable guidance for the design and development of NC-loaded DMNs in the future.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"965-974"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment. 从结膜囊插入物中持续释放溴莫尼定，以降低治疗青光眼的眼内压。

Expert opinion on drug delivery Pub Date : 2024-06-01 Epub Date: 2024-07-16 DOI: 10.1080/17425247.2024.2378082

Zhutian Zhang, Qian Ma, Zhaoxing Dai, Jiaxu Hong, Jifeng Gu, Rong Shi, Jianjiang Xu, Yaling Ma, Xinghuai Sun, Jianguo Sun

{"title":"Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment.","authors":"Zhutian Zhang, Qian Ma, Zhaoxing Dai, Jiaxu Hong, Jifeng Gu, Rong Shi, Jianjiang Xu, Yaling Ma, Xinghuai Sun, Jianguo Sun","doi":"10.1080/17425247.2024.2378082","DOIUrl":"10.1080/17425247.2024.2378082","url":null,"abstract":"Background: Glaucoma is one of the major irreversible blinding eye diseases in the world. Reducing intraocular pressure (IOP) is the primary treatment option, and taking eye drops daily is the common method. However, short drug duration and poor bioavailability of eye drops may lead to unsatisfied therapeutic effects and inadequate patient compliance.Methods: A brimonidine-loaded silicone rubber insert (BRI@SR@PT) was prepared by loading brimonidine into a surface-modified silicone rubber ring, followed by polydopamine/thermoplastic polyurethane coatings. The physical properties, in vitro cytocompatibility and drug release of BRI@SR@PT were investigated. The BRI@SR@PT was administrated in the conjunctival sac of rabbit eyes, and its in vivo drug release, IOP-lowering efficacy and biosafety were assessed.Results: The BRI@SR@PT presented great thermal stability and excellent elasticity. The BRI@SR@PT was able to release BRI sustainably for 28 days with little toxicity in vitro. Compared to BRI eye drops, the BRI@SR@PT effectively lowered IOP for 21 days based on the sustained BRI release with great biosafety when administrated in conjunctival sac of rabbit eyes in a noninvasive fashion.Conclusions: The conjunctival sac insert (BRI@SR@PT), as a promising drug-delivery platform, may provide a sustained IOP-lowering treatment for patients with ocular hypertension or glaucoma, without the need for invasive procedures.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"975-986"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding nanoparticle-liver interactions in nanomedicine. 了解纳米医学中纳米粒子与肝脏的相互作用。

Expert opinion on drug delivery Pub Date : 2024-06-01 Epub Date: 2024-07-04 DOI: 10.1080/17425247.2024.2375400

Yuxin He, Yifan Wang, Lin Wang, Wen Jiang, Stefan Wilhelm

引用次数: 0