On the cellular selectivity of targeting peptide-nanoparticle conjugates - a nanoparticle perspective.

Bastian Beitzinger, Bastian Draphoen, Janina Hald, Markus Krämer, Tamara Rudolf, Felicitas Schmitt, Philipp Schwarz, Mika Lindén
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引用次数: 0

Abstract

Introduction: Peptide-targeted nanoparticles are promising drug carriers that can enhance drug efficacy at low systemic doses. However, clinical applications are compromised by off-target effects. Nanoparticle surface chemistry fine-tuning is key for solving these problems.

Areas covered: The literature related to peptide-based, active targeting is reviewed, and critically discussed, with focus on the influence of surface chemistry influences on targetability. Furthermore, issues related to limited in vitro-in vivo predictivity are discussed.

Expert opinion: The potential of more advanced in vitro methods for an increased in vivo prediction is discussed in combination with advanced computational approaches. Efforts toward enhancing endosomal escape are identified as key future developments, in combination with decreasing off-target effects.

靶向肽-纳米粒子偶联物的细胞选择性——纳米粒子视角。
肽靶向纳米颗粒是一种很有前途的药物载体,可以在低全身剂量下增强药物疗效。然而,临床应用受到脱靶效应的影响。纳米粒子表面化学微调是解决这些问题的关键。涵盖领域:综述了与肽基活性靶向相关的文献,并进行了批判性讨论,重点关注表面化学对靶向性的影响。此外,有关有限的体外-体内预测的问题进行了讨论。专家意见:结合先进的计算方法,讨论了更先进的体外方法增加体内预测的潜力。加强内体逃逸的努力被确定为关键的未来发展,并结合减少脱靶效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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