Expert opinion on drug delivery最新文献_第7页

Feasibility of switching between different autoinjector designs: positive insights from formative Comparative Use Human Factors studies. 在不同的自动注射器设计之间切换的可行性：来自形成性比较使用人为因素研究的积极见解。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.1080/17425247.2025.2514222

Chloé Stoll, Anne Combedazou, Laurie Brunet-Manquat, Camélia Tabet, Cécile Frolet

{"title":"Feasibility of switching between different autoinjector designs: positive insights from formative Comparative Use Human Factors studies.","authors":"Chloé Stoll, Anne Combedazou, Laurie Brunet-Manquat, Camélia Tabet, Cécile Frolet","doi":"10.1080/17425247.2025.2514222","DOIUrl":"10.1080/17425247.2025.2514222","url":null,"abstract":"Background: Users may switch drug-device products when transitioning to generic versions. For autoinjectors, such switches can involve user interface differences, particularly in the activation mechanism, requiring either a push-on-skin step or button activation. It is essential to demonstrate that the use of a generic product remains safe and effective. This article provides preliminary usability data on various autoinjector designs, focusing on generic drug-device combination products.Research design and methods: Two formative Comparative Use Human Factors studies assessed the usability of a 3-step candidate generic button-activated autoinjector compared to RLD autoinjectors: study 1 compared it to a 4-step button-activated while study 2 compared it to a 2-step push-on-skin.Results: In study 1, 80% of participants (12/15) performed similarly with both devices. The error rate for the 3-step candidate generic autoinjector was 20% (3/15), compared to 13.3% (2/15) for the 4-step. In study 2, 90% of participants (10/11) performed similarly with both devices, with a 9% (1/11) error rate for the 3-step candidate generic autoinjector and 0% for the 2-step.Conclusion: These studies offer preliminary evidence supporting the feasibility of switching between different autoinjector activation mechanisms without introducing new risks. The main driver of usability results appears to be user familiarity rather than design differences.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1223-1236"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current insights into polymeric micelles for nasal drug delivery. 聚合物胶束鼻腔给药的最新研究进展。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1080/17425247.2025.2511962

Bence Sipos, Fatima Rajab, Gábor Katona, Ildikó Csóka

{"title":"Current insights into polymeric micelles for nasal drug delivery.","authors":"Bence Sipos, Fatima Rajab, Gábor Katona, Ildikó Csóka","doi":"10.1080/17425247.2025.2511962","DOIUrl":"10.1080/17425247.2025.2511962","url":null,"abstract":"Introduction: The nasal administration route has gained peak interest in recent literature and as a noninvasive alternative for efficient drug delivery and increasing bioavailability of active substances. Technological challenges arise from the drug's physicochemical properties and the nasal mucosal barrier for which innovative particle engineering techniques must be implemented, such as using polymeric nanocarriers.Areas covered: This review deals with the importance of the nasal administration route and its connection to polymeric micelles as innovative nanocarriers. The period between 2015-2025 up to date was chosen to search for original research articles where polymeric micelles were applied nasally. The first part demonstrates the utilization of polymeric micelles, followed by a summary of how drug release and permeability can be achieved in the nasal cavity and through the nasal epithelium. The second part reviews the studies conducted on this matter.Expert opinion: The nasal route could be superior to perform as a suitable alternative to conventional routes. Multiple studies have already demonstrated that the main advantages lie in the nose-to-brain drug delivery pathway, which can be conquered via adequately formulated polymeric micelles. As an innovative solution, vaccine delivery is also of great potential by combining the advantages of the delivery route and the polymeric nanocarriers.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1137-1154"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene quantum dots for breast cancer treatment. 石墨烯量子点用于乳腺癌治疗。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1080/17425247.2025.2514715

Gabriela Lopes Gama E Silva, Aryanne Adametz Escarrone Puejo, Breno de Almeida Bertassoni, Bruna Coelho de Almeida, Tatielle Do Nascimento, Eduardo Ricci-Júnior

引用次数: 0

Targeting Alzheimer's disease pathology: influence of nano-based drug delivery systems loaded with a combination of herbal and synthetic drugs. 靶向阿尔茨海默病病理学：草药和合成药物组合负载的纳米药物传递系统的影响。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2025-06-18 DOI: 10.1080/17425247.2025.2513440

Mumtaz, Devika Unnithan, Aysha Bano, Ajay Pratap Singh Chauhan, Javed Ali, Mohammad Ahmed Khan

{"title":"Targeting Alzheimer's disease pathology: influence of nano-based drug delivery systems loaded with a combination of herbal and synthetic drugs.","authors":"Mumtaz, Devika Unnithan, Aysha Bano, Ajay Pratap Singh Chauhan, Javed Ali, Mohammad Ahmed Khan","doi":"10.1080/17425247.2025.2513440","DOIUrl":"10.1080/17425247.2025.2513440","url":null,"abstract":"Introduction: Alzheimer's Disease (AD) is a progressive neurological disorder marked by cognitive decline and memory loss. Current treatments, including acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, provide only symptomatic relief due to poor Blood Brain Barrier (BBB) permeability and side effects. The integration of synthetic and natural drug combinations with nanotechnology offers a promising strategy to enhance drug delivery, efficacy, and overall therapeutic outcomes.Areas covered: This review explores the integration of herbal and synthetic drugs in nano-based delivery systems for AD treatment. It examines co-loading efficiency, release kinetics, and synergistic therapeutic benefits of dual-drug formulations. Additionally, it discusses target-specific ligand functionalization for improved BBB penetration and neuronal targeting, alongside a comparative analysis of dual- vs. single-drug formulations and their impact on disease progression and efficacy.Expert opinion: Current treatments mainly offer early symptomatic relief but fail to target multiple neurobiological mechanisms of AD. Combining established therapies with herbal drugs can enhance efficacy and reduce side effects. Co-loading synthetic drugs and phytoconstituents in one nanoformulation can improve targeted delivery, sustained release, and minimize systemic effects for better outcomes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1155-1170"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving antifungal lipid-based drug delivery against Candida: a review. 改进以脂质为基础的抗真菌药物输送以对抗念珠菌：综述。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-08-01 Epub Date: 2024-10-29 DOI: 10.1080/17425247.2024.2421402

Gabriel Davi Marena, Alba Ruiz-Gaitán, Taís Maria Bauab, Marlus Chorilli

{"title":"Improving antifungal lipid-based drug delivery against Candida: a review.","authors":"Gabriel Davi Marena, Alba Ruiz-Gaitán, Taís Maria Bauab, Marlus Chorilli","doi":"10.1080/17425247.2024.2421402","DOIUrl":"10.1080/17425247.2024.2421402","url":null,"abstract":"Introduction: Fungal infections, particularly those caused by Candida spp. have increased in recent years. A primary contributor to this surge was the COVID-19 pandemic, where many hospitalized patients had secondary fungal infections. Additionally, the emergence of resistant and multi-resistant fungal strains has become increasingly problematic due to the limited therapeutic options available in antifungal treatments.Areas covered: This review presents a comprehensive analysis of recent studies focused on the development and characterization of lipid-based nanosystems as an emerging and promising therapeutic alternative. These systems have been evaluated for their potential to deliver antifungal agents specifically targeting resistant Candida spp. strains, offering a controlled and sustained release of drugs.Expert opinion: Lipid-based nanomaterials are promising tools for the controlled and sustained release of drugs, particularly in treating Candida spp. infections. Although substantial research has been dedicated to development of these nanomaterials, only a few have reached clinical application, such as liposomal amphotericin B, for example. Therefore, it is critical to push forward with advancements to bring these nanomedicines into clinical practice, where they can contribute meaningfully to mitigating the challenge of resistant and lethal fungal strains.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1193-1207"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin-loaded nanoparticles protecting human sperm from oxidative stress during cryopreservation. 携带褪黑激素的纳米颗粒在冷冻保存过程中保护人类精子免受氧化应激。

Expert opinion on drug delivery Pub Date : 2025-07-01 Epub Date: 2025-04-29 DOI: 10.1080/17425247.2025.2499117

Haitao Xi, Xue Gao, Lin Qiu, Yunzhi Wang, Yifan Qiu, Zihao Tao, Miyun Hu, Xinyu Jiang, Qing Yao, Longfa Kou, Junzhao Zhao, Ruijie Chen

{"title":"Melatonin-loaded nanoparticles protecting human sperm from oxidative stress during cryopreservation.","authors":"Haitao Xi, Xue Gao, Lin Qiu, Yunzhi Wang, Yifan Qiu, Zihao Tao, Miyun Hu, Xinyu Jiang, Qing Yao, Longfa Kou, Junzhao Zhao, Ruijie Chen","doi":"10.1080/17425247.2025.2499117","DOIUrl":"10.1080/17425247.2025.2499117","url":null,"abstract":"Background: During the process of sperm cryopreservation, the overproduction of reactive oxygen species (ROS) triggers oxidative stress thereby leading to a reduction in sperm motility and quality. Therefore, it is a feasible strategy to mitigate oxidative damage during cryopreservation by adding antioxidants to freezing media.Research design and methods: In this study, we explored the potential of melatonin to protect sperm from oxidative stress-induced damage by evaluating sperm-related parameters after thawing through self-assembly with a hyaluronic acid-bilirubin conjugate into nanoparticles (M@HBn).Results: The optimized M@HBn exhibited uniform spherical morphology with average particle size of 112.57 ± 9.8 nm, PDI of 0.22 ± 0.02, a surface potential of - 0.43 ± 1.02 mV and entrapment efficiency of 85.1 ± 4.6%. The addition of 5 μM M@HBn demonstrated a notable enhancement in frozen-thawed human spermatozoa viability, motility, and DNA integrity by scavenging ROS. Additionally, the use of M@HBn supplementation in freezing medium resulted in the most mitochondrial stability and total viability as compared to the other groups.Conclusions: These findings suggest that M@HBn have the potential to serve as a novel drug delivery platform for protecting spermatozoa against from cryodamage while enhancing the quality of cryopreserved sperm and the bioavailability of melatonin.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1043-1055"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments in nanofiber-based fast-disintegrating drug delivery systems. 基于纳米纤维的快速崩解给药系统的最新进展。

Expert opinion on drug delivery Pub Date : 2025-07-01 Epub Date: 2025-04-29 DOI: 10.1080/17425247.2025.2497831

Fuat Topuz, Tamer Uyar

{"title":"Recent developments in nanofiber-based fast-disintegrating drug delivery systems.","authors":"Fuat Topuz, Tamer Uyar","doi":"10.1080/17425247.2025.2497831","DOIUrl":"10.1080/17425247.2025.2497831","url":null,"abstract":"Introduction: Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug release by disintegrating rapidly in biological fluids or upon contact with water.Areas covered: Hydrophilic polymers and cyclodextrins (CDs), either separately or in combination, are frequently utilized to accelerate the disintegration of electrospun fibers, enhance the solubility of hydrophobic drugs, and improve drug bioavailability, leading to better therapeutic outcomes. Toward this goal, a systematic literature search was conducted to identify experimental studies (2019-2025) in Web of Science, Google Scholar, and Scopus using the keywords ('fast-disintegrating' OR 'fast-dissolving') AND ('electrospinning' OR 'electrospun') AND ('delivery' OR 'release').Expert opinion: This review examines recent advancements over the past five years in the development of fast-disintegrating drug delivery fibers. It analyzes fiber composition, structural modifications, drug encapsulation routes, and their impact on drug release for oral mucosal delivery. Additionally, it addresses the challenges faced and outlines future directions in the field.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"957-969"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-eluting resorbable coronary scaffolds: a review of recent advances. 药物洗脱可吸收冠状动脉支架：最新进展综述。

Expert opinion on drug delivery Pub Date : 2025-07-01 Epub Date: 2025-04-20 DOI: 10.1080/17425247.2025.2495043

Lowie Vanoverbeke, Johan Bennett

{"title":"Drug-eluting resorbable coronary scaffolds: a review of recent advances.","authors":"Lowie Vanoverbeke, Johan Bennett","doi":"10.1080/17425247.2025.2495043","DOIUrl":"10.1080/17425247.2025.2495043","url":null,"abstract":"Introduction: Device-related persistent adverse events with current DES-use have refocused the attention on a 'leave-nothing-behind' philosophy, in which it is hypothesized that treating coronary stenosis without permanently caging the vessel with a metallic implant would lead to superior clinical outcomes. One of these uncaging technologies is bioresorbable scaffolds (BRS).Areas covered: In this article, we describe the technical specifications and clinical data of currently available BRS devices.Expert opinion: Newer BRS devices have thinner struts and more biocompatible scaffold backbones (either polymer-based or metal-based), resulting in improved radial strength, faster resorption times, and more antithrombogenic properties (e.g. magnesium-based scaffolds). Results of BRS in the treatment of simple coronary artery disease demonstrate favorable clinical efficacy and safety outcome data. It is probable that over the next 5 years more fourth-generation devices with ever-increasing biocompatibility and safety profiles will be investigated and released commercially, resulting in a much more prominent role for BRS, especially in the treatment of simple coronary artery disease in younger patients.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"919-933"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we create customized polypills for personalized drug formulation? 我们可以为个性化的药物配方创造定制的复方药片吗？

Expert opinion on drug delivery Pub Date : 2025-07-01 Epub Date: 2025-04-29 DOI: 10.1080/17425247.2025.2498650

Sheng Qi

引用次数: 0

Recent advances in nanocrystals for arthritis drug delivery. 纳米晶体用于关节炎药物递送的最新进展。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-07-01 Epub Date: 2025-05-31 DOI: 10.1080/17425247.2025.2505758

Luca Morici, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales

{"title":"Recent advances in nanocrystals for arthritis drug delivery.","authors":"Luca Morici, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales","doi":"10.1080/17425247.2025.2505758","DOIUrl":"10.1080/17425247.2025.2505758","url":null,"abstract":"Introduction: More than 500 million people worldwide suffer from arthritis, experiencing daily pain and inflammation. Current treatments for osteoarthritis (OA) and rheumatoid arthritis (RA) are palliative, offering only symptom relief. No disease-modifying OA drugs (DMOADs) capable of restoring joint functionality and regenerating the cartilage matrix have yet been approved by the FDA or EMA.Areas covered: This review highlights recent advances in nanocrystals (NCs) for arthritis drug delivery, including conventional nanosuspensions and novel transdermal microneedles. Special attention is given to intra-articular DMOADs formulated as NC-in-microparticles, designed to extend drug release over months. Papers and reviews with the mentioned contents and published over the last 5 years were included in the review process.Expert opinion: New DMOADs and disease-modifying antirheumatic drugs (DMARDs) are often poorly water-soluble, limiting their clinical progress. The versatility of NCs and nanosuspensions offers a potential advantage over other types of nanoparticles, as they can be adapted to various delivery systems, administration routes, and types of arthritis. Due to the avascular nature of cartilage, exploring the intra-articular route for OA management is essential. Implementing cartilage-targeted strategies or using stimuli-responsive hydrogels can further enhance their therapeutic potential.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1031-1042"},"PeriodicalIF":5.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0