Expert opinion on drug delivery最新文献_第5页

Particle surface coating for dry powder inhaler formulations. 干粉吸入器配方的颗粒表面涂层。

Expert opinion on drug delivery Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1080/17425247.2025.2482052

Yijing Huang, Chanakya D Patil, Kinnari Santosh Arte, Qi Tony Zhou, Li Lily Qu

{"title":"Particle surface coating for dry powder inhaler formulations.","authors":"Yijing Huang, Chanakya D Patil, Kinnari Santosh Arte, Qi Tony Zhou, Li Lily Qu","doi":"10.1080/17425247.2025.2482052","DOIUrl":"10.1080/17425247.2025.2482052","url":null,"abstract":"Introduction: The development of dry powder inhalers (DPIs) is challenging due to the need for micronized particles to achieve lung delivery. The high specific surface area of micronized particles renders them cohesive and adhesive. Addition of certain excipients like magnesium stearate has been reported to coat the particles and improve the aerosolization in the carrier-based DPI. Therefore, application of particle coating in DPI developments has been investigated and expanded over the years, along with the growing need of high-dose carrier-free DPIs.Area covered: In addition to modifying inter-particulate forces, particle coating has also been demonstrated to effectively provide moisture resistance, modify particle morphology, improve the stability of biologics, alter dissolution behaviors for DPI developments. These different coating functions have been discussed in the current work. Moreover, various coating techniques including solvent-based coating, dry coating, and vapor coating, as well as coating characterization have been summarized in the present review.Expert opinion: The extent of particle coating is critical to DPI performance; however, there is a demand for advanced characterization techniques to quantify and understand the coating quality. Further advancements in coating materials, methods, characterization techniques are needed to better relate coating properties to performance, especially for complex drug modalities.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"711-727"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin-loaded nanoparticles protecting human sperm from oxidative stress during cryopreservation. 携带褪黑激素的纳米颗粒在冷冻保存过程中保护人类精子免受氧化应激。

Expert opinion on drug delivery Pub Date : 2025-04-29 DOI: 10.1080/17425247.2025.2499117

Haitao Xi, Xue Gao, Lin Qiu, Yunzhi Wang, Yifan Qiu, Zihao Tao, Miyun Hu, Xinyu Jiang, Qing Yao, Longfa Kou, Junzhao Zhao, Ruijie Chen

{"title":"Melatonin-loaded nanoparticles protecting human sperm from oxidative stress during cryopreservation.","authors":"Haitao Xi, Xue Gao, Lin Qiu, Yunzhi Wang, Yifan Qiu, Zihao Tao, Miyun Hu, Xinyu Jiang, Qing Yao, Longfa Kou, Junzhao Zhao, Ruijie Chen","doi":"10.1080/17425247.2025.2499117","DOIUrl":"https://doi.org/10.1080/17425247.2025.2499117","url":null,"abstract":"Background: During the process of sperm cryopreservation, the overproduction of reactive oxygen species (ROS) triggers oxidative stress thereby leading to a reduction in sperm motility and quality. Therefore, it is a feasible strategy to mitigate oxidative damage during cryopreservation by adding antioxidants to freezing media.Research design and methods: In this study, we explored the potential of melatonin to protect sperm from oxidative stress-induced damage by evaluating sperm-related parameters after thawing through self-assembly with a hyaluronic acid-bilirubin conjugate into nanoparticles (M@HBn).Results: The optimized M@HBn exhibited uniform spherical morphology with average particle size of 112.57 ± 9.8 nm, PDI of 0.22 ± 0.02, a surface potential of - 0.43 ± 1.02 mV and entrapment efficiency of 85.1 ± 4.6%. The addition of 5 μM M@HBn demonstrated a notable enhancement in frozen-thawed human spermatozoa viability, motility, and DNA integrity by scavenging ROS. Additionally, the use of M@HBn supplementation in freezing medium resulted in the most mitochondrial stability and total viability as compared to the other groups.Conclusions: These findings suggest that M@HBn have the potential to serve as a novel drug delivery platform for protecting spermatozoa against from cryodamage while enhancing the quality of cryopreserved sperm and the bioavailability of melatonin.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we create customized polypills for personalized drug formulation? 我们可以为个性化的药物配方创造定制的复方药片吗？

Expert opinion on drug delivery Pub Date : 2025-04-29 DOI: 10.1080/17425247.2025.2498650

Sheng Qi

引用次数: 0

Recent developments in nanofiber-based fast-disintegrating drug delivery systems. 基于纳米纤维的快速崩解给药系统的最新进展。

Expert opinion on drug delivery Pub Date : 2025-04-29 DOI: 10.1080/17425247.2025.2497831

Fuat Topuz, Tamer Uyar

{"title":"Recent developments in nanofiber-based fast-disintegrating drug delivery systems.","authors":"Fuat Topuz, Tamer Uyar","doi":"10.1080/17425247.2025.2497831","DOIUrl":"https://doi.org/10.1080/17425247.2025.2497831","url":null,"abstract":"Introduction: Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug release by disintegrating rapidly in biological fluids or upon contact with water.Areas covered: Hydrophilic polymers and cyclodextrins (CDs), either separately or in combination, are frequently utilized to accelerate the disintegration of electrospun fibers, enhance the solubility of hydrophobic drugs, and improve drug bioavailability, leading to better therapeutic outcomes. Toward this goal, a systematic literature search was conducted to identify experimental studies (2019-2025) in Web of Science, Google Scholar, and Scopus using the keywords ('fast-disintegrating' OR 'fast-dissolving') AND ('electrospinning' OR 'electrospun') AND ('delivery' OR 'release').Expert opinion: This review examines recent advancements over the past five years in the development of fast-disintegrating drug delivery fibers. It analyzes fiber composition, structural modifications, drug encapsulation routes, and their impact on drug release for oral mucosal delivery. Additionally, it addresses the challenges faced and outlines future directions in the field.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-eluting resorbable coronary scaffolds: a review of recent advances. 药物洗脱可吸收冠状动脉支架：最新进展综述。

Expert opinion on drug delivery Pub Date : 2025-04-20 DOI: 10.1080/17425247.2025.2495043

Lowie Vanoverbeke, Johan Bennett

{"title":"Drug-eluting resorbable coronary scaffolds: a review of recent advances.","authors":"Lowie Vanoverbeke, Johan Bennett","doi":"10.1080/17425247.2025.2495043","DOIUrl":"https://doi.org/10.1080/17425247.2025.2495043","url":null,"abstract":"Introduction: Device-related persistent adverse events with current DES-use have refocused the attention on a 'leave-nothing-behind' philosophy, in which it is hypothesized that treating coronary stenosis without permanently caging the vessel with a metallic implant would lead to superior clinical outcomes. One of these uncaging technologies is bioresorbable scaffolds (BRS).Areas covered: In this article, we describe the technical specifications and clinical data of currently available BRS devices.Expert opinion: Newer BRS devices have thinner struts and more biocompatible scaffold backbones (either polymer-based or metal-based), resulting in improved radial strength, faster resorption times, and more antithrombogenic properties (e.g. magnesium-based scaffolds). Results of BRS in the treatment of simple coronary artery disease demonstrate favorable clinical efficacy and safety outcome data. It is probable that over the next 5 years more fourth-generation devices with ever-increasing biocompatibility and safety profiles will be investigated and released commercially, resulting in a much more prominent role for BRS, especially in the treatment of simple coronary artery disease in younger patients.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future applications of self-immolative polymers in drug delivery. 自焚聚合物在药物传递中的应用前景。

Expert opinion on drug delivery Pub Date : 2025-04-15 DOI: 10.1080/17425247.2025.2493228

Elizabeth R Gillies

引用次数: 0

GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases. GalNac-siRNA缀合递送技术促进了典型慢性肝病的治疗。

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1080/17425247.2025.2466767

Zhen-Xin Qin, Ling Zuo, Ziran Zeng, Rongguan Ma, Wenyan Xie, Xiao Zhu, Xiaorong Zhou

{"title":"GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.","authors":"Zhen-Xin Qin, Ling Zuo, Ziran Zeng, Rongguan Ma, Wenyan Xie, Xiao Zhu, Xiaorong Zhou","doi":"10.1080/17425247.2025.2466767","DOIUrl":"10.1080/17425247.2025.2466767","url":null,"abstract":"Introduction: Nucleic acid-based therapeutics have become a key pillar of the 'third wave' of modern medicine, following the eras of small molecule inhibitors and antibody drugs. Their rapid progress is heavily dependent on delivery technologies, with the development of N-acetylgalactosamine (GalNAc) conjugates marking a breakthrough in targeting liver diseases. This technology has gained significant attention for its role in addressing chronic conditions like chronic hepatitis B (CHB) and nonalcoholic steatohepatitis (NASH), which are challenging to treat with conventional methods.Areas covered: This review explores the origins, mechanisms, and advantages of GalNAc-siRNA delivery systems, highlighting their ability to target hepatocytes via the asialoglycoprotein receptor (ASGPR). The literature reviewed covers preclinical and clinical advancements, particularly in CHB and NASH. Key developments in stabilization chemistry and conjugation technologies are examined, emphasizing their impact on enhancing therapeutic efficacy and patient compliance.Expert opinion: GalNAc-siRNA technology represents a transformative advancement in RNA interference (RNAi) therapies, addressing unmet needs in liver-targeted diseases. While significant progress has been made, challenges remain, including restricted targeting scope and scalability concerns. Continued innovation is expected to expand applications, improve delivery efficiency, and overcome limitations, establishing GalNAc-siRNA as a cornerstone for future nucleic acid-based treatments.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"455-469"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is electroporation the key to drug delivery in drug-resistant cancers? 电穿孔是耐药癌症药物传递的关键吗？

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/17425247.2025.2471463

Julita Kulbacka, Vitalij Novickij

引用次数: 0

Transmucosal drug delivery: prospects, challenges, advances, and future directions. 经黏膜给药：前景、挑战、进展和未来方向。

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/17425247.2025.2470224

Francis Brako, Joshua Boateng

{"title":"Transmucosal drug delivery: prospects, challenges, advances, and future directions.","authors":"Francis Brako, Joshua Boateng","doi":"10.1080/17425247.2025.2470224","DOIUrl":"10.1080/17425247.2025.2470224","url":null,"abstract":"Introduction: Traditional administration routes have limitations including first-pass metabolism and gastrointestinal degradation for sensitive drugs (oral) and pain associated with parenteral injections, which also require trained personnel and refrigeration, making them expensive. This has increased interest in alternative routes, with mucosal surfaces being of high priority.Areas covered: Mucosal routes include ocular, oral (buccal/sublingual), nasal and vaginal mucosae which avoid the limitations of the oral and parenteral routes. Though mucosal routes show great potential, they are still hindered by several barriers, especially for systemic absorption, resulting in the development of more advanced novel drug delivery systems to overcome these limitations and achieve therapeutic actions both locally and systemically, similar to or exceeding the oral route. This paper systematically reviews and compares the different mucosal routes, challenges, and recent advances in advanced novel drug delivery system design for emerging clinical challenges including the advent of large biological macromolecules (proteins, peptides, and RNA) for treatment and prevention of diseases. The review also focuses on current challenges and future perspectives.Expert opinion: Among the various transmucosal routes discussed, nose-to-brain drug delivery has the greatest translational potential to go beyond the current state of the art and achieve significant clinical impact for neurological diseases.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"525-553"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines. 亚单位抗原递送：用于下一代疫苗的乳剂和脂质体佐剂。

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17425247.2025.2474088

Al Zahraa Khalifa, Yvonne Perrie, Aliasgar Shahiwala

{"title":"Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines.","authors":"Al Zahraa Khalifa, Yvonne Perrie, Aliasgar Shahiwala","doi":"10.1080/17425247.2025.2474088","DOIUrl":"10.1080/17425247.2025.2474088","url":null,"abstract":"Introduction: Developing new vaccines to combat emerging infectious diseases has gained more significance after the COVID-19 pandemic. Vaccination is the most cost-effective method for preventing infectious diseases, and subunit antigens are a safer alternative to traditional live, attenuated, and inactivated vaccines.Areas covered: Challenges in delivering subunit antigens and the status of different vaccine adjuvants. Recent research developments involving emulsion and liposomal adjuvants and their compositions and properties affecting their adjuvancy.Expert opinion: Lipid-based adjuvants, e.g. emulsions and liposomes, represent a paradigm shift in vaccine technology by enabling robust humoral and cellular immune responses with lower antigen doses, a property that is particularly critical during pandemics or in resource-limited settings. These adjuvants can optimize vaccine administration strategies by potentially reducing the frequency of booster doses, thereby improving patient compliance and lowering healthcare costs. While emulsions excel in dose-sparing and broadening immune responses, liposomes offer customization and precision in antigen delivery. However, the broader clinical application of these technologies is not without challenges. Stability issues, e.g. the susceptibility of emulsion-based adjuvants to freezing and their reliance on cold-chain logistics, pose significant barriers to their use in remote/underserved regions. Future developments will likely focus on improving manufacturing scalability and cost-effectiveness.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"583-597"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0