Expert opinion on drug delivery最新文献_第5页

A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers. 一项随机交叉研究对两种多剂量粉末吸入器的关键误差、偏好和易用性进行了评估。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1080/17425247.2024.2416511

Pjotr Tinke, Wendy van Beurden, Martijn Goosens, Job van der Palen

{"title":"A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers.","authors":"Pjotr Tinke, Wendy van Beurden, Martijn Goosens, Job van der Palen","doi":"10.1080/17425247.2024.2416511","DOIUrl":"10.1080/17425247.2024.2416511","url":null,"abstract":"Background: The effectiveness of inhaled medications in asthma and COPD is significantly impacted by inhalation errors. Feedback mechanisms, built into the design of the inhaler might reduce the number of critical errors. This study compares critical errors, preferences, and ease of use of two dry powder inhalers, the Nexthaler, and the Turbuhaler.Research design and methods: In this multi-center, prospective, randomized, open-label, cross-over study, the proportions of asthma and COPD patients making critical errors were compared between the Nexthaler and Turbuhaler after 4 weeks of clinical use, after having been trained for the correct use of both inhalers.Results: Ninety and 49 patients with asthma and COPD, respectively, were assessed. No significant difference was found in the number of critical errors between the two inhalers (3 with Nexthaler and 5 with Turbuhaler). However, more patients preferred the Nexthaler (57.6%) over the Turbuhaler (34.5%) (p = 0.006), while 7.9% stated no preference.Conclusions: The study found no significant differences in critical error rate between the Nexthaler and Turbuhaler but the Nexthaler was preferred over the Turbuhaler. This study highlights the importance of dedicating sufficient time to instructing patients on the correct inhalation technique, which can lead to long-term retention of the inhalation technique.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1889-1896"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer's disease: current approaches and future perspectives. 探索纳米颗粒平台，为阿尔茨海默氏症治疗提供再利用药物：当前方法与未来展望。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-13 DOI: 10.1080/17425247.2024.2414768

Snigdha Chakraborty, Sukriti Vishwas, Vancha Harish, Gaurav Gupta, Keshav Raj Paudel, Muralikrishnan Dhanasekaran, Bey Hing Goh, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Popat Kumbhar, John Disouza, Kamal Dua, Sachin Kumar Singh

{"title":"Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer's disease: current approaches and future perspectives.","authors":"Snigdha Chakraborty, Sukriti Vishwas, Vancha Harish, Gaurav Gupta, Keshav Raj Paudel, Muralikrishnan Dhanasekaran, Bey Hing Goh, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Popat Kumbhar, John Disouza, Kamal Dua, Sachin Kumar Singh","doi":"10.1080/17425247.2024.2414768","DOIUrl":"10.1080/17425247.2024.2414768","url":null,"abstract":"Introduction: Alzheimer's disease (AD) stands as significant challenge in realm of neurodegenerative disorder. It is characterized by gradual decline in cognitive function and memory loss. It has already expanded its prevalence to 55 million people worldwide and is expected to rise significantly. Unfortunately, there exists a limited therapeutic option that would mitigate its progression. Repurposing existing drugs and employing nanoparticle as delivery agent presents a potential solution to address the intricate pathology of AD.Areas covered: In this review, we delve into utilization of nanoparticular platforms to enhance the delivery of repurposed drugs for treatment of AD. Firstly, the review begins with the elucidation of intricate pathology underpinning AD, subsequently followed by rationale behind drug repurposing in AD. Covered are explorations of nanoparticle-based repurposing of drugs in AD, highlighting their clinical implication. Further, the associated challenges and probable future perspective are delineated.Expert opinion: The article has highlighted that extensive research has been carried out on the delivery of repurposed nanomedicines against AD. However, there is a need for advanced and long-term research including clinical trials required to shed light upon their safety and toxicity profile. Furthermore, their scalability in pharmaceutical set-up should also be validated.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1771-1792"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How can pressurized gyration revolutionize drug delivery? 加压回旋如何彻底改变给药方式？

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI: 10.1080/17425247.2024.2415482

Yanqi Dai, Mohan Edirisinghe

引用次数: 0

Amorphous solid dispersion to facilitate the delivery of poorly water-soluble drugs: recent advances on novel preparation processes and technology coupling. 无定形固体分散体促进水溶性差药物的输送：新型制备工艺和技术耦合的最新进展。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1080/17425247.2024.2423813

Chengxiang Luo, Ruipeng Li, Mi Tang, Yuan Gao, Jianjun Zhang, Shuai Qian, Yuanfeng Wei, Peiya Shen

{"title":"Amorphous solid dispersion to facilitate the delivery of poorly water-soluble drugs: recent advances on novel preparation processes and technology coupling.","authors":"Chengxiang Luo, Ruipeng Li, Mi Tang, Yuan Gao, Jianjun Zhang, Shuai Qian, Yuanfeng Wei, Peiya Shen","doi":"10.1080/17425247.2024.2423813","DOIUrl":"10.1080/17425247.2024.2423813","url":null,"abstract":"Introduction: Amorphous solid dispersion (ASD) technique has recently been used as an effective formulation strategy to significantly improve the bioavailability of insoluble drugs. The main industrialized preparation methods for ASDs are mainly hot melt extrusion and spray drying techniques; however, they face the limitations of being unsuitable for heat-sensitive materials and organic reagent residues, respectively, and therefore novel preparation processes and technology coupling for developing ASDs have received increasing attention.Areas covered: This paper reviews recent advances in ASD and provides an overview of novel preparation methods, mechanisms for improving drug bioavailability, and especially technology coupling.Expert covered: As a mature pharmaceutical technology, ASD has broad application prospects and values. During the period from 2012 to 2024, the FDA has approved 49 formulation products containing ASDs. However, with the diversification of drug types and clinical needs, the traditional formulation technology of ASDs is gradually no longer sufficient to meet the needs of clinical medication. Therefore, this review summarizes the studies on both novel preparation processes and technology combinations; and provides a comprehensive overview of the mechanisms of ASD to improve drug bioavailability, in order to better select appropriate preparation methods for the development of ASD formulations.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1807-1822"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative drug delivery strategies for targeting glioblastoma: overcoming the challenges of the tumor microenvironment. 针对胶质母细胞瘤的创新给药策略：克服肿瘤微环境的挑战。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1080/17425247.2024.2429702

Sidra Khot, Anandha Krishnaveni, Sankalp Gharat, Munira Momin, Chintan Bhavsar, Abdelwahab Omri

{"title":"Innovative drug delivery strategies for targeting glioblastoma: overcoming the challenges of the tumor microenvironment.","authors":"Sidra Khot, Anandha Krishnaveni, Sankalp Gharat, Munira Momin, Chintan Bhavsar, Abdelwahab Omri","doi":"10.1080/17425247.2024.2429702","DOIUrl":"10.1080/17425247.2024.2429702","url":null,"abstract":"Introduction: Glioblastoma multiforme(GBM) presents a challenging endeavor in therapeutic management because of its highly aggressive tumor microenvironment(TME). This complex TME, characterized by hypoxia, nutrient deprivation, immunosuppression, stromal barriers, increased interstitial fluid pressure and the presence of the blood-brain barrier(BBB), frequently compromises the efficacy of promising therapeutic strategies. Consequently, a deeper understanding of the TME and the development of innovative methods to overcome its associated challenges are essential for improving treatment outcomes in GBM.Areas covered: This review critically evaluates the major obstacles within the GBM TME, focusing on the biological and structural barriers that limit therapeutic delivery and efficacy. Novel approaches designed to address these barriers, including advanced formulation strategies and precise targeting mechanisms, are explored in detail. Additionally, the review highlights the potential of emerging technologies such as 3D-printed models, scaffolds, Robotics and artificial intelligence(AI) techniques and machine learning, in tackling TME- associated hurdles.Expert opinion: The integration of these innovative methods presents a promising path for enhancing the specificity and efficacy of GBM therapies. By combining these advanced strategies, the potential for improving patient outcomes in GBM treatment can be significantly enhanced, offering hope for overcoming the limitations posed by the TME.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1837-1857"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France. 患者对辅助生殖技术笔式注射器的偏好：法国的离散选择实验。

Expert opinion on drug delivery Pub Date : 2024-12-01 DOI: 10.1080/17425247.2024.2434030

Noémie Ranisavljevic, Chadi Yazbeck, Sabrina Vaugon, Céline Nuyttens, Caroline Bernard, Thelma Arcelin, Justin Kirion, Sandrine Baffert, Claire Castello-Bridoux, Laura Luciani, Patricia Marino, Michaël Grynberg

{"title":"Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France.","authors":"Noémie Ranisavljevic, Chadi Yazbeck, Sabrina Vaugon, Céline Nuyttens, Caroline Bernard, Thelma Arcelin, Justin Kirion, Sandrine Baffert, Claire Castello-Bridoux, Laura Luciani, Patricia Marino, Michaël Grynberg","doi":"10.1080/17425247.2024.2434030","DOIUrl":"10.1080/17425247.2024.2434030","url":null,"abstract":"Background: The preference of patients in the choice of pen injectors for Assisted Reproduction Technology (ART) is an important issue for treatment adherence. This study, based on discrete choice experiment (DCE), aimed to elicit patients' preferences of the characteristics of all pen injectors available in France.Research design and methods: A DCE with 12 choice sets was developed to measure the preferences of 6 attributes: pre-injection steps, injection device, dose release, post-injection display, dose reduction method, and dose counter. A mixed logistic model was used to determine the preference ranks and calculate utility score.Results: The study involved 155 women who had previous experience with the use of injector pens with an average age of 34.1 years. Statistically significant results showed that the most essential characteristics were dose confirmation (p < 0.0001), dose counter with digits (p < 0.0001), multi-use pen (p < 0.0001) and ready-to-use pens (p < 0.0001). Estimation of the utilities showed statistically significant difference in favor of Gonal-f®/Pergoveris® (reference modalities) versus other pens, and the largest difference was with Rekovelle® [95% CI:-1,37;-0.85], and Bemfola® [95% CI:-2.25;-1,52].Conclusions: This study show that respondent preferred pen that are ready to use, can be used multiple times, have dose injection confirmation, and display the dose with digits.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1897-1908"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting. 乳腺癌；流行病学、诊断障碍以及乳腺纳米otheranostics 和靶向机制的当代趋势。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1080/17425247.2024.2412823

Mohamed Ibrahim, Zeinab Fathalla, Adel Al Fatease, Ali H Alamri, Hamdy Abdelkader

{"title":"Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting.","authors":"Mohamed Ibrahim, Zeinab Fathalla, Adel Al Fatease, Ali H Alamri, Hamdy Abdelkader","doi":"10.1080/17425247.2024.2412823","DOIUrl":"10.1080/17425247.2024.2412823","url":null,"abstract":"Introduction: Breast cancer is one of the main causes of mortality in women globally. Early and accurate diagnosis represents a milestone in cancer management. Several breast cancer diagnostic agents are available. Many chemotherapeutic agents in conventional dosage forms are approved; nevertheless, they lack cancer cell specificity, resulting in improper treatment and undesirable side effects. Recently, nanotheranostics has emerged as a new paradigm to achieve safe and effective cancer diagnosis and management.Area covered: This review provides insight into breast cancer epidemiology, barriers hindering the early diagnosis, and effective delivery of chemotherapeutics. Also, conventional diagnostic agents and recent nanotheranostic platforms have been used in breast cancer. In addition, mechanisms of cancer cell targeting and nano-carrier surface functionalization as an effective approach for chemotherapeutic targeting were reviewed along with future perspectives.Expert opinion: We proposed that modified nano-carriers may provide an efficacious approach for breast cancer drug targeting. These nanotheranostics need more clinical evaluations to confirm their efficacy in cancer management. In addition, we recommend the use of artificial intelligence (AI) as a promising approach for early and efficient assessment of breast lesions. AI allows better interpretation and analysis of nanotheranostic data, which minimizes misdiagnosis and avoids the belated intervention of health care providers.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1735-1754"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities. 糖尿病视网膜病变的先进给药策略：关于当前药物、给药方法、设备创新、克服障碍和实验模型的全面综述。

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1080/17425247.2024.2431577

Mengistie Diress, Susbin Raj Wagle, Patrick Lim, Thomas Foster, Bozica Kovacevic, Corina Mihaela Ionescu, Armin Mooranian, Hani Al-Salami

{"title":"Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities.","authors":"Mengistie Diress, Susbin Raj Wagle, Patrick Lim, Thomas Foster, Bozica Kovacevic, Corina Mihaela Ionescu, Armin Mooranian, Hani Al-Salami","doi":"10.1080/17425247.2024.2431577","DOIUrl":"10.1080/17425247.2024.2431577","url":null,"abstract":"Introduction: Diabetic retinopathy, a significant trigger for blindness among working age individuals with diabetes, poses a substantial global health challenge. Understanding its underlying mechanisms is pivotal for developing effective treatments. Current treatment options, such as anti-VEGF agents, corticosteroids, laser photocoagulation, and vitreous surgery, have their limitations, prompting the exploration of innovative approaches like nanocapsules based drug-delivery systems. Nanoparticles provide promising solutions to improve drug delivery in ocular medicine, overcoming the complexities of ocular anatomy and existing treatment constraints.Areas covered: This review explored advanced therapeutic strategies for diabetic retinopathy, focusing on current medications with their limitations, drug delivery methods, device innovations, and overcoming associated barriers. Through comprehensive review, it aimed to contribute to the discovery of more efficient management strategies for diabetic retinopathy in the future.Expert opinion: In the next five to ten years, we expect a revolutionary shift in how diabetic retinopathy is treated. As we deepen our understanding of oxidative stress and metabolic dysfunction, antioxidants with specialised delivery matrices are poised to take center stage in prevention and treatment strategies. Our vision is to create a more integrated approach to diabetic retinopathy management that not only improves patient outcomes but also reduces the risks associated to traditional therapies.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1859-1877"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can radiopharmaceuticals be delivered by quantum dots? 量子点能否输送放射性药物？

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1080/17425247.2024.2419446

Derya İlem-Özdemir, Ralph Santos-Oliveira

引用次数: 0

How can nanoemulsions be used for photosensitizer drug delivery? 纳米乳剂如何用于光敏剂给药？

Expert opinion on drug delivery Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1080/17425247.2024.2430395

Italo Rodrigo Calori, Antonio Claudio Tedesco

引用次数: 0