Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent delivery.

Natinael Koyra, Haitao Yu, Calum J Drummond, Jiali Zhai, Brendan Dyett
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Abstract

Introduction: Lyotropic liquid crystalline lipid nanoparticles (LNPs) are a platform technology with broad-ranging potential in bioactive agent delivery applications. Their biomimetic properties impart the capacity to encapsulate large biomolecules and to overcome traditional biological barriers.

Areas covered: The properties of lyotropic liquid crystalline LNPs can vary significantly between phases. We briefly introduce key concepts related to their formation and self-assembly and how ionization at the lipid-water interface, i.e. pH-responsiveness, can be leveraged to alter the properties of the nanoparticles. In this review, we summarize recent advances mainly from the past five years that highlight the role and impact of incorporating ionizable lipids, copolymers, and drug molecules in pH-responsive nanocarriers for the delivery of bioactive agents.

Expert opinion: The development of pH-responsive lipid nanoparticles (pR_LNPs) is at the forefront of the new wave of mRNA therapeutics. The complexity of the biological journey faced by the nanoparticle and the broad spectrum of disease targets is sparking a surge in research activity. The accelerating development of new ionizable lipid materials to enhance mRNA delivery potential may benefit from closer consideration - or in tandem development - of self-assembly, interface ionization, and artificial intelligence integration.

用于靶向生物活性药物递送的ph响应性溶性液晶脂质纳米颗粒的最新进展。
简介:溶性液晶脂质纳米颗粒(LNPs)是一种平台技术,在生物活性药物输送应用中具有广泛的潜力。它们的仿生特性赋予了它们包裹大分子和克服传统生物屏障的能力。涉及领域:溶致液晶LNPs的性质在不同相之间会有很大的差异。我们简要介绍了与它们的形成和自组装相关的关键概念,以及如何利用脂水界面的电离,即ph响应性来改变纳米颗粒的性质。在这篇综述中,我们主要总结了近五年来的最新进展,这些进展突出了在ph响应纳米载体中加入可电离脂质、共聚物和药物分子的作用和影响。专家意见:ph响应脂质纳米颗粒(pR_LNPs)的开发处于mRNA治疗新浪潮的前沿。纳米粒子所面临的生物旅程的复杂性和广泛的疾病靶标引发了研究活动的激增。加速开发新的可电离脂质材料,以增强mRNA的传递潜力,可能受益于更密切的考虑-或同步开发-自组装,界面电离和人工智能集成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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