Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Evaluating the Impact of Angle Kappa on Effective Optical Zone in Kerato-Lenticule Extraction (KLEx) Surgery with Intraoperative Angle Kappa Adjustment.","authors":"Tsung-Hsien Tsai, Erh-Tsan Lin, Jui-Hung Hsu, Chi-Chin Sun","doi":"10.2147/OPTH.S517130","DOIUrl":"https://doi.org/10.2147/OPTH.S517130","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the influence of preoperative angle kappa on postoperative effective optical zone (EOZ) in KLEx patients with intraoperative angle kappa adjustment.</p><p><strong>Methods: </strong>This retrospective study included 174 eyes from 89 myopic patients who underwent the KLEx procedure with intraoperative angle kappa adjustments. Preoperative angle kappa (µ) was approximated as the chord distance between the pupil center and corneal vertex. The cohort was divided into two groups: large angle kappa (µ > 0.2 mm, n = 84) and small angle kappa (µ ≤ 0.2 mm, n = 90). EOZ parameters, including EOZ reduction ratio (RR=EOZ/planned optical zone, %), major and minor axis, decentration, and eccentricity, were measured at one month postoperatively. Linear regression analyses were performed to assess the relationships between preoperative angle kappa and postoperative EOZ parameters.</p><p><strong>Results: </strong>Postoperatively, RR, major and minor axis, decentration and eccentricity did not differ significantly between groups. Univariate linear regression revealed significant but modest negative correlation of angle kappa with RR and minor axis (adjusted R<i>²</i> = 0.05 and 0.03; P = 0.003 and 0.02, respectively). Further, multivariate regression incorporating preoperative spherical equivalent demonstrated that angle kappa was not a significant predictor of EOZ parameters.</p><p><strong>Conclusion: </strong>In conclusion, our study showed that preoperative angle kappa had minimal effect on EOZ parameters in KLEx surgery when appropriate intraoperative adjustments for angle kappa were implemented.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1417-1426"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionality and Priming Stream Patterns of the Ahmed Glaucoma Valve in a Laboratory Setting.","authors":"Iden M Amiri, Heran W Gebreyesus, Jennifer L Patnaik, Malik Y Kahook, Leonard K Seibold","doi":"10.2147/OPTH.S512260","DOIUrl":"https://doi.org/10.2147/OPTH.S512260","url":null,"abstract":"<p><strong>Purpose: </strong>To determine if there is a significant association between the steady state pressure of Ahmed Glaucoma Valves (AGVs) and the fluid pattern exhibited during the priming step of implantation.</p><p><strong>Methods: </strong>In this experimental laboratory study, fifty AGVs were primed according to manufacturer guidelines by injecting balanced salt solution through a 27-gauge cannula. Group 1 consisted of 8 AGVs with a distinct stream priming pattern. Group 2 consisted of 7 AGVs without a distinct stream priming pattern (pooling). These valves were further tested using a perfusion system to measure steady-state pressure across the valve. A Student's <i>t</i>-test was used to assess the differences in mean steady-state pressures.</p><p><strong>Results: </strong>43/50 AGVs (86%) demonstrated a distinct stream of fluid during priming (group 1), while 7 (14%) showed a pooling of fluid only, without a focal stream (group 2). Steady-state pressure was achieved by 45 seconds for the 15 samples. The mean steady-state pressure (± standard deviation) at 60 seconds was 11.00 ± 1.90 mmHg for group 1 and 10.31 ± 2.53 mmHg for group 2 (p = 0.56), demonstrating no significant difference between groups.</p><p><strong>Conclusion: </strong>The most common fluid pattern observed is a focal stream of fluid exiting the valve, with a minority exhibiting a slow pooling of fluid. The fluid pattern observed during AGV priming does not predict the valve's functionality, as both priming patterns resulted in similar steady-state pressures, which were consistently in line with manufacturer specifications.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1411-1416"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Comparative Performance Analysis of Multifocal Eyecryl Actv IOL and the World's First Progressive Polyfocal Autofocus Pro IOL.","authors":"Arvind Kumar Morya, Prateek Nishant, Arshi Singh, Sony Sinha, Ramesh Chandra Shah","doi":"10.2147/OPTH.S521607","DOIUrl":"https://doi.org/10.2147/OPTH.S521607","url":null,"abstract":"<p><strong>Purpose: </strong>This is the first study evaluating the visual outcomes of the novel Progressive Polyfocal Autofocus Pro intraocular lens (IOL) (Lifeline Medical Devices Pvt. Ltd. Aurangabad, India) and comparing them with Eyecryl Actv multifocal IOL (model DIYHS600ROH, Biotech Vision Care Pvt. Ltd. Ahmedabad, India) at the first and sixth weeks after implantation in Indian eyes.</p><p><strong>Patients and methods: </strong>A retrospective nonrandomized, comparative study was conducted based on hospital records of patients operated for cataract between January 2019 and January 2021 with bilateral implantation of one of the two presbyopia-correcting IOLs. Patients aged between 11 and 78 years, with preoperative astigmatism of 1 diopter or less and no other ocular disorders, were included. Visual acuity for distance, intermediate and near, refractive outcomes, contrast sensitivity, reading speed, depth of focus, patient satisfaction, and presence of optical phenomenon classically faced with conventional presbyopia-correcting IOLs were evaluated at 6 weeks postoperatively.</p><p><strong>Results: </strong>Of 104 eligible patients, intermediate visual acuity scores, reading speed, contrast sensitivity, depth of focus, and patient satisfaction were better with the Autofocus Pro IOL (all P<0.001). Negative dysphotopsias were absent in the Autofocus Pro group, whereas they were seen in about one-third of patients in the Multifocal group (P<0.001). Halos and glare were also significantly lower in the Autofocus Pro group. There was no difference in the distance and near visual acuity.</p><p><strong>Conclusion: </strong>This study highlights superior clinical outcomes and patient satisfaction associated with Autofocus Pro IOLs compared to Multifocal IOLs, indicating their potential as a preferred choice for cataract surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1387-1399"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling of the Soft Shell Technique Using Computational Fluid Dynamics.","authors":"Ippei Watanabe, Hirokazu Mukuno","doi":"10.2147/OPTH.S520105","DOIUrl":"https://doi.org/10.2147/OPTH.S520105","url":null,"abstract":"<p><strong>Purpose: </strong>To clarify how ophthalmic viscosurgical devices (OVDs) behave during the soft shell technique.</p><p><strong>Methods: </strong>We simulated the fluids dynamics of a Dispersive-OVD [Combination of 3% hyaluronic acid (HA) and 4% chondroitin sulfate] and Cohesive-OVD (1% HA with a high molecular weight) during the soft shell technique using the software program Fluent2023R2 and ICEM CFD. During the simulation, 0.1 mL of Dispersive-OVD was injected into the eye model for 9 sec, followed by 0.1 mL of Cohesive-OVD for 5 sec. The mass fraction, static pressure, velocity, shear rate and apparent viscosity of each OVD were evaluated during intraocular injection.</p><p><strong>Results: </strong>Initially, the Dispersive-OVD was injected upward into the anterior chamber. Although the pressure applied to the cannula tip during injection was high, almost no pressure rise occurred inside the eye. Subsequently, injection of Cohesive-OVD pushed the Dispersive-OVD up, forming a thin layer of Dispersive-OVD covering the entire corneal endothelium. Injection of Cohesive-OVD increased the velocity magnitude towards the eye incision; once the OVD filled the eye, it overflowed from the incision. The shear rate of Cohesive-OVD was higher than that of Dispersive-OVD when injected through the cannula lumen and out of the tip. Therefore, the apparent viscosity of Cohesive-OVD near the cannula tip was about one-third lower than that of Dispersive-OVD. The shear rate of the Dispersive-OVD at the corneal endothelial surface during Cohesive-OVD injection was less than 10^-1-10 s^-1, and the apparent viscosity was less than 30-100 Pa∙s.</p><p><strong>Conclusion: </strong>Fluid dynamics simulation demonstrated how the soft shell technique works using two agents with different physical properties. The parameters obtained in this study provide useful metrics for understanding and predicting OVD behavior during eye surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1427-1433"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Mining on the Ocular Surface Health Among Residents of Mining Communities.","authors":"Smruti Rekha Priyadarshini, Sujata Das, Mamatha M Reddy, Srikant Kumar Sahu, Komal Sukhadev Avhad","doi":"10.2147/OPTH.S512119","DOIUrl":"https://doi.org/10.2147/OPTH.S512119","url":null,"abstract":"<p><strong>Purpose: </strong>Despite known associations between air pollution and ocular health, the specific impact of mining dust on ocular surface health remains largely unexplored. This study aims to address this gap by determining the ocular surface characteristics, the prevalence of dry eye disease (DED), tear film inflammatory markers, and their clinical correlation among people residing in mining communities.</p><p><strong>Methods: </strong>This was a prospective one-year study at a primary eye care centre that included 376 participants. The participants were categorized into three sub-groups based on the duration of exposure to mining activities, namely high exposure (A: >8 h), moderate exposure (B: 2-8 h;), and minimal exposure (C: <2 h). The participants underwent thorough clinical examinations, ocular surface disease index (OSDI) scoring, Schirmer's test (without anaesthesia), ocular surface analyser and surface staining. The tear samples were analysed for selected inflammatory markers, such as interleukin-1Ra, interleukin-6, interleukin-8, tumour necrosis factor-alpha (TNF-α), and matrix metalloproteinase 9 using multiplex enzyme-linked immunosorbent assay. Bivariate and multivariate regression models with odds ratios were used for the statistical analyses.</p><p><strong>Results: </strong>The prevalence of dry eyes was 15.4%. The OSDI and Schirmer's test scores were poor in group C and A as compared to group B. The risk of DED (p<0.05) increased with advancing age and elevated blood pressure and correlates with surface staining. No significant association could be established between the inflammatory markers and dry eyes using cytokine titres.</p><p><strong>Conclusion: </strong>DED is prevalent in mining communities. Safety gear, periodic eye examinations, and appropriate treatment are recommended.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1401-1410"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRESERFLO Microshunt™ versus Non-Penetrating Deep Sclerectomy for Glaucoma Management, One-Year Results.","authors":"Bruna Cunha, Pedro Gil, Edgar Lopes, Maria Elisa-Luís, Maria Reina, Teresa Gomes, Joana Cardigos","doi":"10.2147/OPTH.S514126","DOIUrl":"https://doi.org/10.2147/OPTH.S514126","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the short-term efficacy and safety of the PRESERFLO™ MicroShunt (PF) versus Non-Penetrating Deep Sclerectomy (NPDS) with Esnoper^®.</p><p><strong>Methods: </strong>Retrospective comparative cohort study at a tertiary hospital including 79 eyes from 79 patients submitted to surgery (32 PF implantation, Group 1 and 47 NPDS, Group 2) between January 2022 and August 2023, with one year follow-up. Outcome measures included intraocular pressure (IOP), complications, surgical duration, postoperative major and minor interventions. Surgical failure was defined as IOP>21 mmHg or <20% reduction from baseline, IOP<5 mmHg, major postoperative intervention, or loss of light perception. Conversely, success was defined as the absence of these failure criteria: complete success without glaucoma medications, and qualified success with.</p><p><strong>Results: </strong>Baseline characteristics, including age, sex, IOP, number of IOP-lowering medications, and visual field defects, were comparable between groups (p>0.05). After one year, IOP decreased significantly in both groups (PF: 20.13±6.20 to 15.00±3.15 mmHg; NPDS: 19.57±5.73 to 13.30±3.59 mmHg, both p<0.001). Complete success rates were 28.1% for PF and 40.4% for NPDS (p=0.189), while surgical failure was significantly higher in the PF group (65.6% vs 38.3%, p=0.015). Major reinterventions were more frequent with PF (10 vs 3, p=0.005), partly due to encapsulated blebs, while NPDS required more minor interventions (2 vs 17, p=0.002). Complication rates were similar (31.3% vs 14.9%, p=0.073), but surgical duration was shorter in the PF group (60.03±17.95 min vs 69.91±15.23 min, p=0.008).</p><p><strong>Conclusion: </strong>PF and NPDS share comparable safety profiles. Although PF surgery is faster, it is associated with a higher rate of major postoperative interventions and failure. NPDS, while requiring more minor interventions, such as goniopuncture and needling, rarely demands major re-interventions. NPDS is known for its meticulous and technically challenging technique, but once mastered, it can result in fewer invasive re-interventions and improved efficacy.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1377-1386"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic and Functional Outcomes of Lamellar Macular Hole and Epiretinal Membrane Foveoschisis Surgery: Predictive Factors and Associated Complications - A Retrospective Interventional Study.","authors":"Yosra Er-Reguyeg, Sihame Doukkali, Mélanie Hébert, Eunice Linh You, Serge Bourgault, Mathieu Caissie, Éric Tourville, Ali Dirani","doi":"10.2147/OPTH.S499493","DOIUrl":"https://doi.org/10.2147/OPTH.S499493","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the anatomic and functional outcomes of lamellar macular hole (LMH) and epiretinal membrane foveoschisis (ERMF) surgery.</p><p><strong>Patients and methods: </strong>This is a retrospective interventional cohort study of ninety patients with unilateral idiopathic LMH or ERMF who underwent pars plana vitrectomy (PPV) with membrane peeling between 2014 and 2021. We evaluated the anatomic and functional success of PPV with membrane peeling for treating LMH and ERMF, compared surgical outcomes between the two entities, and identified predictive factors for anatomical and functional success. Primary outcomes included final postoperative best-corrected visual acuity (BCVA) and LMH or ERMF closure. Variables associated with final BCVA were assessed using a multiple linear regression model.</p><p><strong>Results: </strong>51 subjects presented with ERMF, while 39 presented with LMH. LMH or ERMF closure occurred in 80 cases. LMH cases had a lower rate of closure (LMH closure rate: 76.9%, vs ERMF closure rate: 98.0%, p=0.002) and were more at risk of developing a postoperative macular hole (p=0.008). A significant difference was observed between median [Q1, Q3] preoperative BCVA (0.42 [0.26, 0.61] logMAR) and final BCVA (0.31 [0.14, 0.48] logMAR, p=0.024). BCVA varied from 0.52 [0.40, 0.74] logMAR preoperatively to 0.36 [0.30, 0.66] logMAR postoperatively in the LMH subgroup (p=0.060), and from 0.32 [0.20, 0.54] logMAR preoperatively to 0.22 [0.10, 0.40] logMAR postoperatively in the ERMF subgroup (p=0.146). LMH without epiretinal proliferation (β=0.194, p=0.040) was associated with worse final BCVA in multivariate analysis.</p><p><strong>Conclusion: </strong>Results support the effectiveness of PPV as a treatment for LMH. LMHs had worse anatomic outcomes than ERMFs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1365-1376"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Rotational Stability Over Time Between Four Monofocal Toric Intraocular Lenses.","authors":"Peter Hoffmann, Richard Potvin, Robert D Anello, Fritz Hengerer, Gerd Auffarth, Yves Guldenfels, Eckart Bertelmann, Ramon Ruiz Mesa, Isaak Fischinger, Sandra Krawczyk, Berthold Seitz, David Antolin-Garcia, Stefanie Schmickler, Louis Hoffart, Thomas Kohnen, Alvin S Relucio","doi":"10.2147/OPTH.S522728","DOIUrl":"https://doi.org/10.2147/OPTH.S522728","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the rotational stability of four different monofocal toric intraocular lenses (IOLs) from surgery to 4-6 months postoperative.</p><p><strong>Methods: </strong>This was a subset of data from a prospective multi-center randomized clinical study. High resolution retro-illuminated images of eyes implanted with four different toric IOLs were obtained immediately after surgery, and at 1 day, 1 week, 1 month and 4-6 months after surgery. Fixed scleral features were identified in the surgical image. An independent reading center evaluated the orientation of the IOL from all images, based on the angle between the toric axis marks and these fixed scleral landmarks. Rotational stability was determined by calculating differences in orientation between visits.</p><p><strong>Results: </strong>Digital images from 299 eyes implanted with one of the four IOLs were available for analysis. Orientation data were successfully determined in about 90% of images. Biometry and IOL orientation were not significantly associated with IOL rotation. The Vivinex lens showed the lowest absolute rotation, with a mean value less than 1.5 degrees at all time intervals measured, with a maximum standard deviation of 1.4 degrees. The AcrySof lens was next lowest, with an absolute rotation below two degrees for all intervals. Mean absolute rotation for the Tecnis lens was significantly higher than for the other IOLs (>2 degrees for all intervals). For the AcrySof and Vivinex lenses, there were no reported rotations >10 degrees for any interval; 97% or more of results were <5 degrees, compared to 93% for the AT Torbi lens and 90% for the Tecnis lens. Only 6 lenses (4 Tecnis: 8.3%, 2 AT Torbi: 4.3%) had a rotation > 10 degrees at any time point.</p><p><strong>Conclusion: </strong>Rotational stability appeared excellent for the Vivinex and AcrySof toric IOLs, with slightly more variable performance evident with the AT Torbi and Tecnis IOLs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1345-1355"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Occlusion Break Surge Volume in Five Different Phacoemulsification Systems.","authors":"Satish Yalamanchili, Ali Aboughaida, Omid S Rohani, David William Dyk","doi":"10.2147/OPTH.S516801","DOIUrl":"https://doi.org/10.2147/OPTH.S516801","url":null,"abstract":"<p><strong>Purpose: </strong>To compare surge volume after occlusion breaks in five phacoemulsification systems.</p><p><strong>Methods: </strong>A mechanical spring-eye model was used to evaluate the Legion™ Vision System with the Single Use Fluidics Management System (FMS) (LEG), Infiniti™ Vision System with Intrepid™ Plus FMS (INF), Whitestar Signature Pro^® with the OPO73 pack (WSP), Compact Intuitiv^® with the OPO80 pack (CIS), and Stellaris PC^® with the StableChamber cassette (SPC). Transient occlusion break surge volume responses were assessed across a full range of system settings (IOP: 30 to 80 mmHg; vacuum limit: 300 to 650 mmHg; aspiration rate: 20 or 40 cc/min. Oscilloscope waveforms covered stable flow before occlusion, full occlusion, occlusion break, and full recovery to stable flow. Raw oscilloscope data were converted to volumetric and pressure measurements. Fitted average surge traces were generated for each test condition and used to develop an interpolation algorithm to predict transient occlusion break surge events.</p><p><strong>Results: </strong>The minimum surge volume for all systems occurred at the highest IOP (80 mmHg) and the lowest tested vacuum limit (300 mmHg). Overall, the surge volume increased with increasing vacuum limit and decreasing IOP on the LEG, INF CIS, WSP, and SPC systems. The occlusion break surge volumes (µL [standard deviation]) at 60 mmHg IOP and vacuum limit of 500 mmHg were 70.4 [8.1] for LEG; 87.4 [9.7] for INF; 85.8 [7.2] for CIS; 69.5 [5.0] for WSP; and 151.7 [20.2]) for SPC. A Games-Howell post-hoc test showed significant differences between three groups: A) LEG/WSP, B) CIS/INF, and C) SPC.</p><p><strong>Conclusion: </strong>The Legion system demonstrated comparable or lower predicted surge volume after occlusion breaks compared to the other phacoemulsification systems evaluated. Reductions in occlusion break surge volumes are expected to decrease the rate of complications and lead to improved outcomes in the clinical cataract surgery setting.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1357-1364"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Hypertension Following Open Globe Injury in Patients Undergoing Pars Plana Vitrectomy.","authors":"Sam Karimaghaei, Hytham Al-Hindi, Muhammad Z Chauhan, Abdelrahman M Elhusseiny, Carina T Sanvicente, Sami H Uwaydat","doi":"10.2147/OPTH.S499595","DOIUrl":"https://doi.org/10.2147/OPTH.S499595","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors and rates of post-traumatic ocular hypertension (OHT) in patients undergoing pars plana vitrectomy (PPV) for open-globe injuries.</p><p><strong>Patients and methods: </strong>Retrospective chart study including 98 eyes from 98 patients between 2008 and 2022 with open globe injuries who were hospitalized at a single academic institution and received first repair or exploration followed by PPV. Variables recorded included timing to the first PPV, best-corrected final visual acuity (VA) at the last follow-up, incidence of enucleation, type of injury, use of intravitreal antibiotics, number of eye surgeries, use of oral steroids, acetazolamide use, topical steroid use, lens status, silicone oil placement, and zone of injury (1-3). The ocular trauma score (OTS) was calculated using the variables globe rupture, development of endophthalmitis, initial VA, globe perforation, retinal detachment, and the presence of a relative afferent pupillary defect (RAPD). The primary endpoint was elevated intraocular pressure (IOP) sustained for more than six weeks following PPV. We performed a logistic regression to determine the factors that predicted the development of OHT post-PPV.</p><p><strong>Results: </strong>Of 98 eyes included in the primary analysis, a total of 34 (34.69%) were diagnosed with sustained ocular hypertension (OHT) and 64 (65.31%) remained normotensive. The mean final IOP in the OHT group was 16.96 mmHg and 12.11 mmHg in the normotensive group (P < 0.01). Sex, age, OTS, injury type, zone of injury, preoperative IOP, and final VA were comparable between the OHT and normotensive groups. When adjusting for OTS, the use of silicone oil significantly predicted the development of ocular hypertension (odds ratio [95% CI], 5.63 [1.57-20.11]).</p><p><strong>Conclusion: </strong>The incidence of ocular hypertension in our cohort was slightly higher than previously reported at 34.69%. PPV has been independently associated with elevated IOP post-operatively, but the need for PPV surgery can indicate more severe trauma leading to higher rates of increased IOP. Patients who had silicone oil utilized in their PPV had an approximately 5.63-fold increased odds of developing OHT, suggesting that silicone oil use may be a potent predictor of post-PPV OHT.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1339-1344"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}