Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"A Systematic Review of the PAUL Glaucoma Implant.","authors":"Nicholas Tan, Steven Summers, Saif Aldeen Alryalat, Jennifer L Patnaik, Gabriel S Lazcano-Gomez, Leonard K Seibold, Malik Y Kahook","doi":"10.2147/OPTH.S544440","DOIUrl":"10.2147/OPTH.S544440","url":null,"abstract":"<p><p>The PAUL Glaucoma Implant (PGI) is a novel, valveless glaucoma drainage device that is distinguished from prevailing tube shunts by its compact plate and small lumen. However, clinical consensus is lacking on its real-world advantages. Thus, we conducted a systematic review to assess PGI surgical approaches, safety, and efficacy. A comprehensive literature search was performed using PubMed, Embase, Web of Science, and ClinicalTrials.gov. Single case reports were excluded. Twenty-six studies comprising 1143 eyes were included. The most common duration of follow-up was one year, and five studies were prospective. Median IOP reduction by last follow-up was 53.4% (range 27.7-66.2%), and glaucoma medication use decreased by 71.8% (42.3-94.6%). At an intraocular pressure (IOP) upper threshold of 21 mmHg, the median qualified success rate was 92.0% (80.0-100.0%), and complete success was 48.0% (24.0-73.3%); though criteria varied between studies. The most frequently reported complications were hyphema (10.0%), numerical hypotony (9.7%), and shallow anterior chamber (5.9%). Tube erosion occurred in 5.0% of cases overall, and in 9.8% of eyes in prospective studies. A single randomized controlled trial comparing the PGI to the Ahmed Glaucoma Valve in pediatric patients found noninferiority at 12 months, but was limited by sample size and generalizability. Four additional retrospective comparative studies (three versus Baerveldt, one versus Ahmed) showed no consistent advantages of the PGI. Substantial variation was also reported in PGI surgical techniques, including ripcord use, graft material, and adjunctive antifibrotics. While the PGI appears effective in lowering IOP and medication burden, current evidence is limited by retrospective designs, small cohorts, heterogeneous protocols, and short follow-up. Tube erosions were reported more often than historically seen with Baerveldt and Ahmed devices. Higher-quality, prospective comparative studies are needed to determine the long-term safety, efficacy, and optimal surgical approach for the PGI.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3255-3271"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Spectacle Correction Using Defocus Incorporated Multiple Segments in the Myopic Population.","authors":"Marketa Zakova, Martin Fus, Leos Tejkl","doi":"10.2147/OPTH.S541232","DOIUrl":"10.2147/OPTH.S541232","url":null,"abstract":"<p><strong>Aim: </strong>The objective of this study was to evaluate the efficacy of DIMS (Defocus Incorporated Multiple Segments) in comparison to control group (CTRL) in a wide age group of European progressive myopes (6-26 years).</p><p><strong>Methods: </strong>In this prospective, non-randomised observational study, 78 myopes with progression myopia to -0.25 to -8.5 D and astigmatism to -0.25 to -2.25 D chose DIMS (n=54) or single vision lenses (SV) (n=24). Baseline measurements included spherical equivalent refraction (SER) and axial length (AL), evaluated at regular intervals.</p><p><strong>Results: </strong>In participants younger than 15 years of age, slower progression of myopia (SER) (SER -0.25±0.35 D) and reduced axial elongation (0.09 ± 0.16 mm) was observed in Group 1 (DIMS) compared to Group 2 (CTRL) (SER -0.73 ± 0.57 D, AL 0.30 ± 0.20 mm), both significantly at p-value <0.05. In participants over 15 years of age, Group 3 (DIMS) exhibited minimal myopia progression (SER -0.24 ± 0.29D) and negligible axial elongation (0.00 ± 0.07 mm), Group 4 (CTRL) demonstrated more pronounced axial elongation (SER -0.20 ± 0.53D, AL 0.01 ± 0.06 mm).</p><p><strong>Conclusion: </strong>It can be stated that the DIMS variant is 68.7% more effective in the category of subjects younger than 15 years of age in the effect on AL and 65.6% more effective in the effect on SER compared to the SV lenses. This deceleration in myopia progression is statistically significant in the under 15 age group. A statistically significant difference in the effect on SER in this age group was observed for DIMS.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3191-3199"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Depth-of-Focus Estimation from Wavefront Measurements After Implantation of an Isofocal Intraocular Lens.","authors":"Mohamed Hosny, Sarah Azzam, Ahmed Ibrahim Howaidy, Rawan Hosny, Mohamed Anis","doi":"10.2147/OPTH.S536795","DOIUrl":"10.2147/OPTH.S536795","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the objective depth-of-focus after implantation of isofocal intraocular lens (IOL) during cataract surgery based on VSOTF using ray tracing aberrometry.</p><p><strong>Methods: </strong>In this prospective study, 40 eyes were implanted with the isofocal Isopure IOL (Beaver-Visitec International, Inc. [BVI], Waltham, USA). The patient assessments considered: refraction (sphere, cylinder and axis), uncorrected-distance visual acuity (UDVA), corrected-distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA, at 60 and 80 cm), distance-corrected and uncorrected near visual acuity (DCNVA and UNVA), wavefront aberrations and objective depth-of-focus using ray-tracing optical technology from several percentages of degradation on the visual Strehl ratio based on the optical transfer function (VSOTF, 90%, 80% and 60%). Patients were assessed at 3 months post-surgery.</p><p><strong>Results: </strong>Eyes implanted with the isofocal IOL showed good outcomes in terms of refraction and visual acuity at the last follow-up visit. Specifically, half a dioptre was obtained for the spherical equivalent and about 20/20 for CDVA, about 20/25 for UIVA at 80 cm, about 20/30 for UIVA at 60 cm, and about 20/25 for DCNVA. In relation to the objective depth-of-focus computed from the wavefront analysis in our cohort, we obtained mean values of 2.12 D, 3.16 D and 4.94 D at 90%, 80% and 60% of degradation, respectively.</p><p><strong>Conclusion: </strong>Our study shows that the isofocal IOL provides high values of objective depth-of-focus based on the VSOTF using ray tracing optical technology when implanted after cataract surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3207-3213"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Preserflo Microshunt in Different Subtypes of Glaucoma.","authors":"Ahmed Al Habash, Askar K Alshaibani","doi":"10.2147/OPTH.S551700","DOIUrl":"10.2147/OPTH.S551700","url":null,"abstract":"<p><strong>Background: </strong>Glaucoma is the leading cause of blindness worldwide. Intraocular pressure is considered the only modifiable risk factor; different modalities have been developed to target this risk factor. Trabeculectomy, a gold standard glaucoma surgery, carries high complication rate, as a result alternative different modalities were developed to mitigate this risk. A newly developed device, Preserflo Microshunt, aims to decrease the complication rate of trabeculectomy with similar efficacy. In this study, we assessed the safety and efficacy of the device in Saudi Arabia, where the patient population has a darker skin color with more intense scarring and a hot climate that can exacerbate ocular surface dryness and compromise conjunctival health.</p><p><strong>Purpose: </strong>This retrospective study aims to assess the safety and efficacy of Preserflo Microshunt with Mitomycin C 0.5 mg/mL in managing different subtypes of glaucoma.</p><p><strong>Methods: </strong>Retrospective, interventional single-arm study.</p><p><strong>Results: </strong>This study included 45 eyes from 45 patients. It included 33 (73.3%) males and 12 (26.7%) females. A median age of 56 years (Interquartile Range 39-63, range 20-77). The Preserflo Microshunt with Mitomycin C 0.5 mg/mL achieved a complete success rate 83.3% at 6 months follow-up and of 80% at 1 year. A significant reduction in both the number of anti-glaucoma medications and intraocular pressure at 1 month, 3 months, 6 months, and 1 year post-operatively was observed (P<0.001 for all). The most common early-onset complication was transient hypotony, observed in 12 eyes (26.7%), and the most common late-onset complication was cataract progression, which was observed in 5 (16.67%) patients at 1 year.</p><p><strong>Conclusion: </strong>Preserflo Microshunt is a viable option for glaucoma patients showing excellent success and low complication rates with good safety profile.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3215-3226"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond-Laser-Assisted Liquid-Interface vs Vacuum-Trephine Keratoplasty: A Comparison of 2 Different Techniques - Retrospective Data Analysis.","authors":"Michal Klimek, Irene Steiner, Ruth Donner, Christian Skorpik, Julia Aschauer, Gerald Schmidinger, Jan Lammer","doi":"10.2147/OPTH.S542124","DOIUrl":"10.2147/OPTH.S542124","url":null,"abstract":"<p><strong>Purpose: </strong>To compare postoperative astigmatism and visual acuity (VA) outcomes in patients undergoing penetrating keratoplasty (PK) using a liquid-interface femtosecond laser (LI-fs) trephination and a conventional vacuum-trephine (VT) technique.</p><p><strong>Methods: </strong>Our single-center, retrospective data analysis included 121 eyes (121 patients) treated between April 2014 and November 2022. Patients received PK either with a LI-fs or a VT system. Pre- and postoperative topography (K-values), refraction (cylinder) and visual acuity (VA) were measured up to 18 months after surgery. Data were analyzed by descriptive statistics, ANCOVA, and paired t-tests within each group.</p><p><strong>Results: </strong>Preoperative and postoperative astigmatism were similar between the two techniques (LI-fs: 5.4 ± 3.4 D pre-OP vs 6.7 ± 4.2 D post-OP; VT group: 5.8 ± 4.8 D vs 6.7 ± 3.8D). An ANCOVA adjusting for baseline astigmatism (=∆K in topography imaging) revealed no statistically significant difference between groups (estimate [95% CI]: -0.79 [-2.73; 1.15], p = 0.42). Within-group changes in astigmatism were also not significant. For VA, a paired <i>t</i>-test showed a significant increase of post-OP VA in the VT group (mean change 0.25 [0.15; 0.34], p < 0.0001), while the smaller LI-fs group showed no significant change (mean 0.16 [-0.11; 0.44], p = 0.22).</p><p><strong>Conclusion: </strong>Despite the characteristics of LI-fs in maintaining corneal curvature, LI-fs and conventional VT generated comparable outcomes in terms of post-OP astigmatism. The results underscore the need for further research with larger cohorts to clarify any potential advantages of the LI-fs in reducing surgically-induced astigmatism.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3201-3206"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Primary Congenital Glaucoma: Results of a Nationwide Descriptive Study in France (CONGLAU).","authors":"Jean-François Rouland, Adèle Mekerke, Florent Aptel","doi":"10.2147/OPTH.S534442","DOIUrl":"10.2147/OPTH.S534442","url":null,"abstract":"<p><strong>Purpose: </strong>Childhood glaucoma is rare but severe, with no recognized standard surgical procedure. We conducted a retrospective, observational, multicenter study describing surgical practices for primary congenital glaucoma (PCG) in France.</p><p><strong>Patients and methods: </strong>This study was conducted between 2013 and 2018 using data from PCG patients aged <4 years at 16 reference centers in France. Intraocular pressure (IOP) (baseline [pre-surgery], 1 month, 1 year), initial surgical procedure, antimitotic (mitomycin C [MMC]) use, secondary intervention(s), and surgical success (complete, relative, or failure) were recorded.</p><p><strong>Results: </strong>Overall, 116 eyes (83 patients) were included. The most common surgeries were trabeculotomy (31.0%) and trabeculotomy combined with trabeculectomy (20.7%). A further 11 other types of surgery were performed for <10% of eyes. Median IOP was reduced in each surgical group at 1 month (the largest median reduction being for combined trabeculotomy/non-perforating deep sclerectomy [-60%]) and at 1-year (the largest median reduction being for trabeculectomy [-55%]). Anti-glaucomatous treatment was administered in 30.4% of cases, most commonly for trabeculectomy (66.7%). Complete and relative surgical success were observed for 21.5% and 33.6% of surgical procedures overall, with complete success most common for trabeculotomy (47.1%). When MMC was used (51.8% of surgical procedures overall, excluding trabeculotomy), surgery was less successful (complete success 3.6% <i>versus</i> 40.8%) and further interventions were more common.</p><p><strong>Conclusion: </strong>There was a trend towards better effectiveness of angle-based surgery (eg, trabeculotomy). The findings suggest that MMC may not be essential in first-line PCG surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3177-3189"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Effects of Faricimab in Aflibercept Low-Responders: Retinal Morphology and Function in Eyes with Neovascular Age Related Macular Degeneration Following a Switch Between Two Anti-VEGF Agents.","authors":"Jan Rothbächer, Haidar Khalil, Markus Eidherr, Matthias Bolz","doi":"10.2147/OPTH.S530355","DOIUrl":"10.2147/OPTH.S530355","url":null,"abstract":"<p><strong>Purpose: </strong>To assess how transitioning from an Aflibercept to a Faricimab intravitreal treatment impacts retinal structures and functional aspects in patients with neovascular age related macular degeneration (nAMD) in a real-life setting.</p><p><strong>Patients and methods: </strong>A retrospective clinical study including 49 patients (57 eyes) with nAMD at the Department of Ophthalmology and Optometry, Kepler University Hospital, Linz, Austria was performed. The patients, who had previously been receiving monthly Aflibercept injections with an unsatisfactory treatment response, were switched to intravitreal Faricimab and followed-up between 12/2022 and 12/2023.</p><p><strong>Results: </strong>The mean treatment-interval before the fifth injection with Faricimab was 5.35 ± 1.49 weeks and was therefore significantly longer compared to the monthly interval with Aflibercept (<i>p < 0.001)</i>. Mean baseline central retinal thickness (CRT) was 267.82 ± 76.00 µm and decreased significantly already at month 1 to 249.61 ± 65.35 µm (<i>p < 0.001</i>). After the fourth intravitreal injection, there was no significant change with a CRT of 252.95 ± 56.96 µm (<i>p = 0</i>.134). There was a significant reduction in the number of patients showing subretinal fluid (SRF) and intraretinal fluid (IRF). In eyes with fibrovascular pigment epithelium detachment (PED), an interval extension was not possible in more than half of the cases. Eyes with serous and drusenoid PED and a rather high amount of hyper-reflective foci (HRF), the majority showed a significant response after the switch.</p><p><strong>Conclusion: </strong>An initial loading dose could be beneficial to elongate Faricimab's additional effect of reducing retinal swelling in eyes with nAMD and previous low-response to Aflibercept. Serous and drusenoid PEDs seem to benefit more than fibrovascular PEDs. A high amount of intraretinal HRF in patients with PED was a sign for good respondence to Faricimab.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3145-3152"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of a Multicenter Study Following Implantation of an Isofocal Optic IOL with Double C-Loop Haptics.","authors":"Sheraz Daya, Takayuki Akahoshi, Camille Bosc, Romain Mouchel, Christophe Chassain, Emmanuel Van Acker, Alessandra Di Maria, Paolo Fogagnolo","doi":"10.2147/OPTH.S542276","DOIUrl":"10.2147/OPTH.S542276","url":null,"abstract":"<p><strong>Purpose: </strong>To report clinical outcomes in patients implanted with an isofocal optic-design intraocular lens (IOL) with double C-loop haptics following cataract surgery.</p><p><strong>Methods: </strong>This was a multicentre-prospective-study involving 108 eyes (54 subjects) implanted with the Isopure Serenity (BVI, Inc). IOL. At least 3 months after the surgery, the following parameters were analysed: refraction, monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA) and distance corrected-intermediate visual acuity (DCIVA) both at 80 and 66 cm, uncorrected near visual acuity (UNVA), and distance corrected near visual acuity (DCNVA) at 40 cm. In addition, the binocular defocus curve was measured.</p><p><strong>Results: </strong>79.63% and 98.15% of eyes were within ±0.50D and ±1.00D of the target spherical equivalent, respectively. 68.41% and 98.15% of eyes had a UDVA and CDVA of 20/20 or better, respectively, with 88.89% and 99.07% achieving 20/25 or better, respectively (the mean values for UDVA and CDVA were 0.02±0.11 and -0.04±0.05 logMAR, respectively). 77.14% and 39.39% of eyes achieved a DCIVA of 20/32 or better at 80 cm and 66 cm, respectively, and 90% and 72.73% achieved a DCIVA of 20/40 or better at 80 and 66 cm, respectively (the mean values for DCIVA were 0.19±0.10 and 0.28±0.11 logMAR, 80 cm and at 66 cm, respectively). 25% and 15.15% of eyes had a UNVA and DCNVA of 20/32 or better, respectively, with 39.81% and 31.82% achieving a UNVA and DCNVA of 20/40 or better, respectively (mean values for UNVA and DCNVA were 0.37±0.15 logMAR and 0.40±0.13 logMAR, respectively). The defocus curve showed a peak of visual acuity at far distance with a depth-of-focus value of about 1.75D.</p><p><strong>Conclusion: </strong>Patients implanted with the new Isopure Serenity IOL with double C-loop haptics showed good visual performance at far distance with functional intermediate vision and accurate refractive outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3121-3131"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision-Related Quality of Life Outcomes Following Endoscopic Dacryocystorhinostomy in Chronic Dacryocystitis: A Prospective Cohort Study.","authors":"Xinyu Zheng, Xinyue Yu, Kerui Wang, Ziwei Meng, Can Yang, Jiayi Zhang, Jing Zhao, Chengzhen Gong, Rongxin Chen, Zuohong Li, Xuanwei Liang","doi":"10.2147/OPTH.S540589","DOIUrl":"10.2147/OPTH.S540589","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess the vision-related quality of life in patients with chronic dacryocystitis (CD) and to investigate the impact of Endoscopic Dacryocystorhinostomy (En-DCR) and the timing of the procedure on patients' quality of life.</p><p><strong>Methods: </strong>A prospective cohort of 57 patients diagnosed with chronic dacryocystitis and scheduled for surgical intervention between August 2023 and December 2023 was initially recruited, with 54 patients completing the entire follow-up period. A control group consisting of 69 healthy individuals, matched for age and sex, was also included. The National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) was employed to compare the preoperative visual function questionnaire (VFQ) scores between the patient group and the control group.</p><p><strong>Results: </strong>The study demonstrated that the VQF score in the preoperative patient cohort was significantly lower than that of the control group (p<0.0001). This disparity was primarily observed in the domains of eye pain (p=0.0053), distance activities (p=0.0251), role difficulties (p=0.0280), and mental health (p=0.0044). Postoperative VQF scores exhibited significant improvement compared to preoperative scores (p<0.05), with the change in VQF score showing a negative correlation with the duration of the disease (p<0.0001, r=-0.6634). Furthermore, no significant difference in VQF scores was observed between the catheterized and non-catheterized groups (p>0.05).</p><p><strong>Conclusion: </strong>The study found that patients with chronic dacryocystitis experience a significant reduction in vision-related quality of life. The En-DCR procedure effectively alleviates symptoms in CD patients and enhances their vision-related quality of life, with earlier surgical intervention leading to greater improvements.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3167-3176"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Between Macular Vessel Density and Its Clinical Parameters in Diabetes Mellitus Type 2.","authors":"Nadia Artha Dewi, Muhammad Arfan, Herisa Rahmasari, Mutiara Kristiani Putri, Rulli Rosandi","doi":"10.2147/OPTH.S532859","DOIUrl":"10.2147/OPTH.S532859","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate macular vessel density using clinical parameters in patients with type 2 diabetes mellitus (DM) without retinopathy.</p><p><strong>Patients and methods: </strong>This cross-sectional study enrolled 32 participants (63 eyes) aged 40-60 years who met the inclusion criteria. Group 1 included 32 eyes of type 2 DM, whereas the rest had no DM. Ophthalmic examination was performed. Macular vessel density was measured using optical coherence tomography angiography (OCTA) with a 6 × 6 mm scan. Macular vessel density is correlated with patient age, HbA1c values, disease duration, and contrast sensitivity. The data were analyzed using Spearman's rank correlation and an independent <i>t</i>-test.</p><p><strong>Results: </strong>Central (foveal area) macular vessel density in the diabetic group (5.36 ± 2.87) was significantly lower than that in healthy participants (7.82 ± 3.05) (p = 0.002). The whole macular vessel density (foveal and parafoveal areas) was also lower in the DM group than in the healthy subjects (15.76 ± 3.38 vs 17.18 ± 1.92) but the difference was not statistically significant (p = 0.070). The age of DM patients has correlated with central (r = -0.522; p = 0.002) and whole macular vessel density (r = -0.369; p = 0.038). HbA1c levels, diabetes duration, and contrast sensitivity were not correlated with macular vessel density.</p><p><strong>Conclusion: </strong>Macular vessel density was lower in DM patients without retinopathy than in healthy subjects. In patients with DM, macular vessel density decreases with increasing age. We failed to find a correlation between macular vessel density and the HbA1c value, disease duration, or contrast sensitivity.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3113-3120"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}