Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Age-Related Macular Degeneration and Circadian Preference.","authors":"Estefany Garces, Katarzyna Slota, Michael W Stewart, Maria P Guzman, Natalia M Werninck, Pablo R Castillo","doi":"10.2147/OPTH.S487389","DOIUrl":"10.2147/OPTH.S487389","url":null,"abstract":"<p><strong>Purpose: </strong>Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations. Within the retina, a subset of cells, called <i>melanopsin-containing intrinsically photosensitive retinal ganglion cells</i>, are implicated in circadian rhythms, prompting a search for a potential connection between circadian behavior and AMD. Our objective was to compare the chronotype (ie, preference for morning or evening activity) of individuals with AMD to that of those without ocular conditions.</p><p><strong>Patients and methods: </strong>The Horne-Östberg Morningness-Eveningness questionnaire was administered to previously screened patients with wet AMD who received bilateral anti-vascular endothelial growth factor eye injections (study participants) as well as those without eye pathology (controls). Thirty-one study participants and 19 controls completed the survey and were included in the analysis. We used Wilcoxon rank sum test and Fisher exact test for continuous and categorical variables respectively.</p><p><strong>Results: </strong>Study participants had a higher median age compared to controls (83 vs 75, <i>P</i><0.001). No significant difference in body mass index was observed between respondents. While the disparity in survey responses between study participants and controls was generally not statistically significant, more study participants struggled with attending exercises between 7:00 and 8:00 in the morning compared to controls (45% vs 21%, <i>P</i>=0.02). Additionally, fewer study participants expressed the need to sleep before 10:15 pm compared to controls (55% vs 63%, <i>P</i>=0.04). Study participants tended to have a delayed sleep-wake cycle.</p><p><strong>Conclusion: </strong>In this pilot study, study participants encountered greater challenges with morning exercise compared to controls. Nonetheless, there was no significant difference in chronotype between study participants and controls. The study could serve as a foundation for more extensive research exploring the interplay between vision loss and circadian rhythms.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"899-905"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year Outcome of Aflibercept Administration with \"Treat and Extend\" for Neovascular Age-Related Macular Degeneration.","authors":"Iori Wada, Yuji Oshima, Yosuke Fukuda, Satomi Shiose, Kumiko Kano, Keijiro Ishikawa, Shintaro Nakao, Yoshihiro Kaizu, Eiichi Hasegawa, Ram Kannan, Tatsuro Ishibashi, Koh-Hei Sonoda","doi":"10.2147/OPTH.S501953","DOIUrl":"https://doi.org/10.2147/OPTH.S501953","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the outcomes of aflibercept treatment using a treat-and-extend (TAE) regimen over up to 5 years in Japanese patients with neovascular age-related macular degeneration (nAMD).</p><p><strong>Patients and methods: </strong>This retrospective study included 126 consecutive treatment-naïve nAMD patients (126 eyes) who received at least three monthly intravitreal aflibercept (IVA) injections as a loading phase, followed by a treat-and-extend (TAE) regimen with follow-up for 5 years. Injection intervals were adjusted every 2 weeks and could be extended up to 16 weeks based on macular condition. Treatment was suspended if patients received 3 injections at 16-week intervals and the macula remained dry (defined as \"monitoring\"). Ophthalmic exams were conducted at each visit to assess disease activity.</p><p><strong>Results: </strong>The mean logarithm of the minimum angle of resolution (logMAR) best corrected visual acuity (BCVA) at baseline was 0.42 ± 0.036. Following loading injections, the mean BCVA exhibited a significant improvement. Although it subsequently declined, it sustained the initial visual acuity. The average macular thickness (CMT) was significantly reduced and maintained throughout the follow-up period. The number of aflibercept injections decreased significantly from the second year and gradually decreased during the follow-up period. Intravitreal aflibercept (IVA) treatment could be discontinued in 36 (44%) cases during the follow-up period. However, 12 of these eyes (33%) experienced recurrence. Notably, significant recurrence was observed in patients who received a higher total number of aflibercept injections. Macular atrophy was significantly more likely to occur in cases with occult macular neovascularization (MNV) with subretinal hemorrhage than in cases with other forms of nAMD.</p><p><strong>Conclusion: </strong>The long-term outcomes of IVA treatment utilizing TAE regimens for nAMD in real-world practice have demonstrated favorable results, including the maintenance of visual acuity and improvement in CMT over a 5-year period.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"835-845"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hemodialysis on Glaucoma Patients.","authors":"Tina M Hendricks, Tyler S Quist, Kai Wang, Lisa M Antes, Erin A Boese","doi":"10.2147/OPTH.S513421","DOIUrl":"https://doi.org/10.2147/OPTH.S513421","url":null,"abstract":"<p><strong>Purpose: </strong>Prospective study to determine if patients with glaucoma are at increased risk of intraocular pressure (IOP) fluctuation and changes in ocular perfusion pressure (OPP) during hemodialysis (HD) sessions when compared to patients without glaucoma.</p><p><strong>Patients and methods: </strong>Patients undergoing HD at the University of Iowa for end-stage renal disease were recruited. Enrollment was restricted to patients undergoing standard HD sessions for a minimum of three months. Hand-held slit lamp examination, IOP, blood pressure (BP), and central corneal thickness (CCT) measures were taken at the following three time points: the beginning of the session <i>(before</i>), at the half-way point <i>(middle)</i>, and at the conclusion of the session <i>(end)</i>. Ocular perfusion pressure was calculated using the formula: 2/3[diastolic BP + 1/3 (systolic BP - diastolic BP)] - IOP.</p><p><strong>Results: </strong>Every eligible patient having dialysis was approached, and 105 eyes of 54 patients were recruited for the study. The glaucoma cohort included 19 eyes from 11 patients. The variability in IOP from the beginning to the end of HD (<i>end-before</i>) was 1.54 mmHg greater in the glaucoma group (p=0.005), with some glaucoma patients having IOP increases up to 25 mmHg. Ocular perfusion pressure decreased significantly more in glaucoma patients compared to controls at both <i>middle-before</i> (p=0.008), and <i>end-before</i> (p=0.01) time points.</p><p><strong>Conclusion: </strong>Glaucoma patients may be more vulnerable to IOP swings and drops in OPP during HD sessions compared to controls. In all cases, these changes were asymptomatic, potentially placing glaucoma patients at increased risk for glaucomatous progression during each HD session. Our results suggest that HD may be an independent risk factor for glaucomatous progression, and may be especially worth investigating in patients with progression despite low to normal IOPs measured in clinic.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"827-834"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Stage Reconstructive Surgery of the Eyeball with No Light Perception After Severe Open Globe Injury.","authors":"Lyubomyr M Lytvynchuk, Makar Ponomarov, Erick Carlos Reyna, Knut Stieger, Monika Andrassi-Darida","doi":"10.2147/OPTH.S474942","DOIUrl":"https://doi.org/10.2147/OPTH.S474942","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the visual and anatomical outcomes of multi-stage reconstructive surgery of the eyeball with no light perception (NLP) in patients after severe open globe injury (OGI).</p><p><strong>Patients and methods: </strong>In this retrospective consecutive case series study, medical records of patients with severe OGI with visual loss up to NLP, who were referred to our clinic between February 1, 2016, and March 30, 2021, were included. The analysis of epidemiologic data, type and severity of OGI, timing and type of surgical treatment, and anatomical and functional results was performed.</p><p><strong>Results: </strong>Nine patients met our inclusion criteria. The mean age was 52 years (range 34-78 years). Mean follow-up was 24 months (range 1-56 months). Estimated mean best corrected visual acuity (BCVA) was 2.92 LogMAR immediate after trauma, 2.27 LogMAR before reconstructive anterior segment surgery and 2.42 LogMAR at last follow-up. The functional gain after the primary repair was highly significant (p 0.005), but a non-significant gain was seen at the last follow-up. Retina reattachment was achieved in most of the cases (6/7, 85.7%), but these remained silicone oil dependent (5/6, 83.33%). In all cases, it was possible to prevent primary enucleation.</p><p><strong>Conclusion: </strong>The multi-stage reconstructive surgical approach allowed for saving the eyes and improved the functional and anatomical condition. Despite the severity of OGI and NLP, an early surgical intervention should be considered by experienced surgeons.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"847-856"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Comfort Eluting Agents and Replacement Frequency on Enhancing Contact Lens Performance.","authors":"Chau-Minh Phan, Alex Hui, Xinfeng Charlie Shi, Ying Zheng, Lakshman N Subbaraman, James Wu, Lyndon Jones","doi":"10.2147/OPTH.S512246","DOIUrl":"https://doi.org/10.2147/OPTH.S512246","url":null,"abstract":"<p><p>This review explores the development and clinical implications of soft contact lenses designed to elute comfort agents, emphasizing their role in enhancing user experience and ocular health. As discomfort remains one of the primary reasons for discontinuation of lens wear, this concept aims to address this challenge by gradually releasing these agents over their period of use. This review also explores the effectiveness, safety, and user satisfaction associated with frequent replacement schedules of these lenses. Clinical trials demonstrate that lenses with eluting comfort agents significantly reduce dryness and irritation, leading to improved wear-time and overall comfort. The findings suggest that frequent replacement not only enhances lens hygiene but also maximizes the therapeutic benefits of the eluted agents, promoting a healthier ocular environment. The implications for practice highlight a shift towards more patient-centered approaches in contact lens design and management, aiming to improve adherence and satisfaction among users. This research paves the way for future innovations in contact lens technology, focusing on personalized solutions that cater to individual comfort needs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"857-873"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Monotherapy to Combination Strategies: Redefining Treatment Approaches for Multiple-Cause Macular Edema.","authors":"Qianwei Zhu, Xuchong Pan, Zhenni Du, Jianing Ying, Yiran Hu, Quanyong Yi, Xiangxiang Fu","doi":"10.2147/OPTH.S513141","DOIUrl":"10.2147/OPTH.S513141","url":null,"abstract":"<p><p>Macular edema (ME) is a leading cause of visual impairment in various retinal disorders. Current treatment modalities, including anti-vascular endothelial growth factor (anti-VEGF) agents and corticosteroids, often require repeated applications, increasing both medical and economic burdens. ME is driven by chronic inflammation and VEGF overexpression, causing fluid accumulation in the macula. Recent studies have highlighted the role of various cytokines in ME pathogenesis, necessitating a comprehensive approach to treatment. While monotherapies have shown efficacy, they are associated with limitations such as the need for frequent injections and potential side effects. Combination therapies, including anti-VEGF drugs with macular laser photocoagulation, triamcinolone acetonide, or dexamethasone intravitreal implant (Ozurdex), have emerged as promising strategies. This review analyzes the outcomes of various combination approaches in different types of ME, including diabetic macular edema (DME), retinal vein occlusion-associated ME (RVO-ME), and uveitic macular edema (UME). The potential benefits of combining anti-VEGF and anti-inflammatory treatments are discussed, along with the need for personalized treatment regimens. Future research directions are outlined, emphasizing the importance of large-scale, long-term studies to evaluate the sustained efficacy and safety of combination therapies. The integration of advanced imaging techniques, biomarker analysis, and innovative therapeutic approaches is expected to shape the future landscape of ME management, moving towards more targeted and effective combination therapies.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"887-897"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Patient Experiences Before and After Monovision LASIK for Hyperopia and Presbyopia: A Qualitative Approach.","authors":"Ermano de Melo Alves, Paulo Schor, Bianca Arruda Manchester Queiroga, Marina Alves Lucena, Márcio Martins de Melo Alves","doi":"10.2147/OPTH.S512371","DOIUrl":"https://doi.org/10.2147/OPTH.S512371","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the social and emotional perceptions of individuals with presbyopia, focusing on the impact of age-related near-vision loss before and after monovision LASIK surgery.</p><p><strong>Patients and methods: </strong>This qualitative study employed semi-structured interviews with individuals diagnosed with presbyopia, along with associated hyperopia and/or astigmatism, and moderate refractive errors suitable for monovision LASIK. The interviews were recorded, transcribed, and analyzed using ATLAS.ti software (version 9.1.1) to identify codes, subthemes, and overarching themes. A thematic content analysis was conducted, with data collection concluding when saturation was reached. A total of 17 participants (9 women, 8 men), aged 48-60 years, were interviewed through 8 face-to-face and 9 videoconferencing sessions.</p><p><strong>Results: </strong>Presbyopia emerged as a significant milestone with emotional and psychological implications, often linked to the perception of aging, such as concerns about diminished independence and appearance. Motivations for surgery included aesthetics, discomfort with glasses, hygiene concerns, and the desire for greater independence. Fear of the procedure was identified as a key barrier, though it was mitigated by social support. Despite initial adaptation challenges, most participants reported favorable outcomes, citing improved self-esteem and a sense of freedom.</p><p><strong>Conclusion: </strong>For carefully selected individuals, monovision LASIK can be an effective strategy for addressing the challenges of presbyopia, particularly with respect to the psychological and social dimensions of aging.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"875-886"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Evaluation of Clinical and Non-Clinical Outcome Metrics in Patient Satisfaction After Implantation of a Non-Constant Aberration-Correcting Monofocal IOL.","authors":"Steven C Schallhorn, David Teenan, Jan A Venter, Julie M Schallhorn, Stephen J Hannan","doi":"10.2147/OPTH.S505584","DOIUrl":"https://doi.org/10.2147/OPTH.S505584","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate patient-reported outcomes after implantation of a non-constant aberration-correcting monofocal IOL and explore factors affecting postoperative satisfaction with vision.</p><p><strong>Methods: </strong>This retrospective study comprised patients who underwent cataract surgery with bilateral implantation of CT LUCIA 621P IOL (Carl Zeiss Meditec AG, Jena, Germany). Factors affecting postoperative satisfaction with vision were evaluated, including patient demographics, clinical and non-clinical variables (visual acuities, adverse events, ocular comorbidities, general health, depression scores, personality types), and other patient-reported outcomes (visual phenomena, dry eye). Questionnaires were used to assess patient-reported visual outcomes, depression, and personality types. The outcomes of the last available clinical visit were evaluated.</p><p><strong>Results: </strong>A total of 97 patients were included, of whom 63.9% reported to be very satisfied and 30.9% were satisfied with postoperative vision. Only three patients were dissatisfied, and the reasons were mostly related to their postoperative clinical findings. In a multivariate logistic regression analysis, the patient's age and postoperative uncorrected visual acuity were significant predictors of postoperative satisfaction. Some non-clinical and clinical variables were signaling potential trends in satisfaction, but a larger cohort of patients would be required to explore them.</p><p><strong>Conclusion: </strong>Satisfaction of cataract patients implanted with a monofocal IOL remains high. When evaluating postoperative satisfaction, non-clinical factors and interactions with other patient-reported outcomes (visual phenomena or dry eye) should not be underestimated.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"795-806"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Corneal Fluorescein and Conjunctival Lissamine Green Staining Combined with in vivo Confocal Microscopy for Grading the Severity of Dry Eye Disease.","authors":"Mian Guo, Bo Huang, Xiaokang Jia, Bo Liu","doi":"10.2147/OPTH.S498893","DOIUrl":"https://doi.org/10.2147/OPTH.S498893","url":null,"abstract":"<p><strong>Objective: </strong>To explore the application of corneal fluorescein sodium (CFS)-conjunctival lissamine green (CLG) staining combined with in vivo confocal microscopy (IVCM) in clinical grading of the severity of dry eye disease (DED).</p><p><strong>Methods: </strong>Eleven normal persons (4 males and 7 females) and thirty-two mild, moderate, and severe DED patients (aged 22 to 56 years, and mean age 45.4 ± 12.9 years;14 males and 18 females) were included for CFS-CLG staining. The stained positive areas were observed and recorded for the number and morphology of staining points. Subsequently, the morphology and cell density of corneal and conjunctival cells were observed and analyzed by IVCM.</p><p><strong>Results: </strong>CFS-CLG staining revealed that the number of CFS-stained points were not significantly increased in mild DED, and there was a small amount of CLG staining in the temporal bulbar conjunctiva; the CFS-stained points of moderate DED were increased compared with mild DED, and the nasal conjunctiva diffuse small flake CLG staining was observed; the cornea of severe DED had the most fluorescein-stained points, and the conjunctiva diffuse large CLG staining. IVCM examination showed that corneal epithelial basal cell density was significantly decreased, while activated corneal Langerhans cells were significantly increased in moderate and severe DED. Meanwhile, the morphology of superficial stromal cells of cornea became irregular and the cell density decreased significantly in moderate and severe DED. The density of conjunctival goblet cells was also significantly reduced in moderate and severe DED. Moreover, the density of activated conjunctival Langerhans cells increased significantly in mild, moderate, and severe DED.</p><p><strong>Conclusion: </strong>Observing and detecting the morphology and density of corneal epithelial basal cells, superficial stromal cells, corneal Langerhans cells, conjunctival goblet cells, and conjunctival Langerhans cells in positive CFS-CLG stained areas by IVCM, which may be a reliable basis for clinical grading of DED severity.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"807-817"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Corneal Thickness Measurement in Patients with Glaucoma and Glaucoma Suspects by Spectral-Domain and Swept-Source Optical Coherence Tomography Compared with the Standard Ultrasonic Method.","authors":"Pedro Machado Luz, Valentina Mostardeiro Lubisco, Rodrigo Leivas Lindenmeyer, Ariadne Peres Swarovsky, Anais Back da Silva, Victoria D Azevedo Silveira, Monica Oliveira Silva, Carolina Schopf, Jaco Lavinsky, Daniel Lavinsky, Helena Messinger Pakter, Fabio Lavinsky","doi":"10.2147/OPTH.S512052","DOIUrl":"https://doi.org/10.2147/OPTH.S512052","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the agreement of central corneal thickness (CCT) measurements between spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) compared with the gold standard ultrasonic corneal pachymetry (US CP).</p><p><strong>Methods: </strong>Adults with glaucoma and glaucoma suspects presenting with typical optic nerve head findings and high intraocular pressure with or without visual field damage were included. Patients underwent anterior segment (AS) SD-OCT (Spectralis, Heidelberg Engineering), AS SS-OCT (DRI-Triton, Topcon), and US CP. For both AS SD-OCT and AS SS-OCT, an 8.3 and a 3.0 mm single horizontal B-scan at the central cornea were performed and manually measured respectively. CCT was measured by three blinded different trained examiners. Intraclass correlation coefficient (ICC) and Bland-Altman plots were used for statistical analysis.</p><p><strong>Results: </strong>Twenty-six eyes from 16 patients with glaucoma and glacuoma suspects were included. The mean (SD) age was 59.1 (10.5) years, and 87% were women. The mean (SD) CCT measurements were 548.04 (33.11) µm for AS SD-OCT, 538.88 (34.84) µm for AS SS-OCT, and 537.12 (29.20) µm for US CP. The overall agreement ICC was 0.915 (95% CI, 0.785-0.964; p<0.001). The best agreement was found between AS SS-OCT and US CP (ICC = 0.929; 95% CI, 0.849-0.967; p<0.001). When comparing AS-OCT methods with US CP, a difference of less than 10 µm was found in 53.8% of the eyes examined by SS-OCT, and in 50% of the eyes examined by SD-OCT.</p><p><strong>Conclusion: </strong>OCT emerges as an effective modality for CCT measurements. This technology provides advantages such as patient comfort, B-scan trackability, and the possibility to conduct multiple glaucoma diagnostic modalities in a single device.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"819-825"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}