Ruilong Li, Ming Yan, Zhen Huang, Ya Ye, Yanping Song
{"title":"Tubercular Uveitis: Multimodal Imaging, Immunologic Stratification, and a Practical Framework for Diagnosis and Management.","authors":"Ruilong Li, Ming Yan, Zhen Huang, Ya Ye, Yanping Song","doi":"10.2147/OPTH.S636135","DOIUrl":"10.2147/OPTH.S636135","url":null,"abstract":"<p><p>Tubercular uveitis (TBU) remains difficult to diagnose and monitor because microbiologic confirmation is uncommon and clinical phenotypes overlap with other inflammatory chorioretinal disorders. This narrative review integrates evidence from multimodal imaging, immune testing, systemic tuberculosis evaluation, molecular diagnostics, biomarkers, treatment response, and monitoring to support a practical probability-based approach to suspected TBU. A targeted search of PubMed, Embase, Web of Science, the Cochrane Library, and Google Scholar was conducted for English-language literature through May 10, 2026, prioritizing consensus statements, systematic reviews, multicenter studies, and clinically relevant imaging, biomarker, and treatment reports. Enhanced-depth and swept-source optical coherence tomography, optical coherence tomography angiography, fundus autofluorescence, indocyanine green angiography, and ultra-widefield fluorescein angiography provide complementary information on choroidal granulomas, serpiginous-like choroiditis, retinal vasculitis, ischemia, and paradoxical worsening. Tuberculin skin testing and interferon-gamma release assays support tuberculosis attribution but do not prove ocular causality, while polymerase chain reaction and emerging molecular assays increase specificity when positive. Cytokine profiles, type I interferon signatures, complement C1q, and cell-free DNA remain investigational. TBU should be managed as a clinicoradiologic and immunologic probability diagnosis that links phenotype, imaging, tuberculosis exposure evidence, mimic exclusion, antitubercular therapy decisions, anti-inflammatory timing, and longitudinal monitoring to reduce both missed TBU and unnecessary treatment.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"636135"},"PeriodicalIF":0.0,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Llovet-Osuna, Jaime Beltran-Sanz, Andrea Llovet-Rausell, Vasyl Druchkiv, Julio Baviera-Sabater
{"title":"Nd:YAG Capsulotomy Rates of Three FineVision Trifocal Intraocular Lens Platform Across Different Platforms: Results from a Multicenter Clinical Registry Study.","authors":"Fernando Llovet-Osuna, Jaime Beltran-Sanz, Andrea Llovet-Rausell, Vasyl Druchkiv, Julio Baviera-Sabater","doi":"10.2147/OPTH.S648297","DOIUrl":"10.2147/OPTH.S648297","url":null,"abstract":"<p><strong>Purpose: </strong>To report the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy rates following implantation of three models of the FineVision (BVI Inc. Waltham, USA) diffractive trifocal intraocular lens (IOL).</p><p><strong>Methods: </strong>This was a multicentre, retrospective study including eyes implanted with the FineVision Micro F, FineVision POD/POD FT and the FineVision HP (POD F GF) IOL models after uncomplicated cataract or refractive lens exchange surgeries. The rate of Nd:YAG laser capsulotomy (cumulative incidence) during 1, 3, 5 and 10 years of follow-up were recorded.</p><p><strong>Results: </strong>190,567 eyes implanted with the three FineVision IOL models were analysed: 170,047 eyes with the FineVision Micro F IOL model, 20,174 eyes with the FineVision POD IOL model, and 346 eyes with the FineVision HP IOL model. Cumulative incidence of Nd:YAG capsulotomy was 3% at 1 year, 6.2% at 3 years, 8.4% at 5 years and 10.9% of eyes at 10 years for the FineVision Micro F IOL model. For the FineVision POD/POD FT IOL model percentages were 6.9% at 1 year, 24.3% at 3 years, and 36.8% of eyes at 5 years. Finally, for the FineVision HP IOL model the percentage at 1 year of follow-up was 6.9% of eyes.</p><p><strong>Conclusion: </strong>Nd:YAG capsulotomies rates varied accordingly to the FineVision IOL model. Differences in IOL material (hydrophilic or hydrophobic) and haptic design (4-closed loops or a double C-loop) could account for these differences.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"648297"},"PeriodicalIF":0.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ema V Karakoleva, Olivia Waldron, Allen R Kunselman, Amanda L Ely
{"title":"Caregiver-Reported Stressors Involved in Caring for a Child with Optic Nerve Hypoplasia.","authors":"Ema V Karakoleva, Olivia Waldron, Allen R Kunselman, Amanda L Ely","doi":"10.2147/OPTH.S590334","DOIUrl":"10.2147/OPTH.S590334","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize quality of life (QoL) and depressive symptoms among caregivers of children with optic nerve hypoplasia (ONH), identify associated demographic and clinical factors, and explore the measurement properties of a modified caregiver QoL instrument.</p><p><strong>Patients and methods: </strong>This cross-sectional survey included 20 primary caregivers of children with ONH who completed a modified 20-item Caregiver's Congenital Glaucoma Quality of Life (CarCGQoL) questionnaire (0-40; higher scores indicate better self-reported QoL), the Patient Health Questionnaire-9 (PHQ-9; 0-27), and a demographic and clinical survey. CarCGQoL analyses required completion of ≥16 of 20 items; clinical and demographic associations and measurement properties were explored.</p><p><strong>Results: </strong>Caregivers had a mean age of 42.7±11.7 years, and 75% were mothers. In primary CarCGQoL analyses (n=19), scores were strongly inversely associated with PHQ-9 scores (<i>r</i> <sub>s</sub>=-0.73, p<0.001); 50% of the full cohort reported at least mild depressive symptoms and 25% moderate-or-greater symptoms. CarCGQoL scores were lower among caregivers of children with bilateral vs unilateral ONH (19.8±7.6 vs 29.9±10.3, p=0.03) and were associated with nystagmus (<i>r</i> <sub>p</sub> <sub>β</sub>=-0.55, p=0.01); nystagmus was also associated with higher PHQ-9 scores (<i>r</i> <sub>p</sub> <sub>β</sub>=0.63, p=0.003). Internal consistency was high among complete responders (Cronbach's α=0.93), although exploratory Rasch analysis identified greatest misfit for the modified item addressing the child's ability to see.</p><p><strong>Conclusion: </strong>Depressive symptoms were common and closely associated with lower modified CarCGQoL scores, while bilateral ONH and nystagmus were associated with poorer caregiver-reported outcomes. These findings support greater attention to caregiver well-being in ONH care and further evaluation of the modified CarCGQoL in larger cohorts.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"590334"},"PeriodicalIF":0.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Punctal Occlusion Techniques in Tear Drainage Disorders: A Systematic Review and Meta-Analysis [Letter].","authors":"Nicholas A Householder, Anahit Simonyan","doi":"10.2147/OPTH.S657541","DOIUrl":"10.2147/OPTH.S657541","url":null,"abstract":"","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"657541"},"PeriodicalIF":0.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateja Jagić, Maja Bohač, Alma Bišćević, Sudi Patel
{"title":"Preoperative Higher-Order Aberrations as Predictors of Visual Acuity Changes Following Presbyopia-Correcting (PCIOL) and Aspheric Monofocal Intraocular Lens Implantation.","authors":"Mateja Jagić, Maja Bohač, Alma Bišćević, Sudi Patel","doi":"10.2147/OPTH.S614799","DOIUrl":"https://doi.org/10.2147/OPTH.S614799","url":null,"abstract":"<p><strong>Purpose: </strong>To determine if preoperative ocular higher order aberrations (HOAs) were associated with changes in uncorrected distance (UCDVA), intermediate (UCIVA), near (UCNVA), corrected distance at reduced contrast (CDVA 10% and 25%) logMAR acuities after PCIOL or aspheric IOL implantation.</p><p><strong>Patients and methods: </strong>Records of patients implanted with AcrySof IQ PanOptix (group I, n = 30), TECNIS Symfony (group II, n = 35), TECNIS bifocal (group III, n = 34), or TECNIS monofocal (group IV, n = 32) were reviewed where UCDVA, reduced contrast CDVA (logMAR chart at 6 m), UCIVA and UCNVA (at 80 cm and 40 cm) assessed under photopic conditions (∼85 cd/m<sup>2</sup>), ocular aberrations (under mesopic conditions, pupil sizes 3mm and 5mm), and refraction had been monitored.</p><p><strong>Results: </strong>Data from one eye/case were included for analysis. The chief findings were: (i) Median UCDVA, UCIVA and UCNVA values improved but CDVA (10% and 25%) remained unchanged in groups I-III. Median UCDVA, CDVA (10% and 25%) improved but UCIVA and UCNVA values remained unchanged in group IV. (ii) Mean spherical aberration (5mm pupil) and total root mean square HOA values (for 3 and 5mm pupil sizes) reduced in all 4 groups (ANOVA, p < 0.001). Mean trefoil and coma values did not change significantly. (iii) There were significant correlations between changes (Δ) in uncorrected acuities, CDVA (10% and 25%) and specific preop HOA values. The limits of agreement in the various models describing these associations were ≤0.2 units of logMAR acuity in groups II for ΔUCIVA and ΔCDVA (10% and 25%), III for ΔUCNVA and ΔCDVA (10% and 25%), IV for ΔUCIVA and ΔCDVA (10% and 25%).</p><p><strong>Conclusion: </strong>Preoperative HOA measurements showed statistically significant though modest associations with changes in uncorrected visual acuities. In some instances, the estimated change improved by including information regarding preoperative refractive error. Validation in larger cohorts is required before clinical implementation.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"614799"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Intraocular Lens and Capsular Bag Complex Suspension Technique for Repositioning Late In-the-Bag Intraocular Lens Dislocation.","authors":"Yingyan Ma, Baojiang Li","doi":"10.2147/OPTH.S618477","DOIUrl":"https://doi.org/10.2147/OPTH.S618477","url":null,"abstract":"<p><strong>Purpose: </strong>To present a novel in situ scleral suspension surgical technique for the management of dislocated intraocular lens (IOL)-capsular bag complex and to evaluate its clinical efficacy.</p><p><strong>Patients and methods: </strong>Patients who underwent the novel in situ scleral suspension technique for in-the-bag IOL dislocation at the Department of Ophthalmology, Shanghai General Hospital, between February 2024 and February 2025, were included. The technique involves performing a scleral puncture 3 mm posterior to the limbus, passing a single suspensory suture twice through the fibrotic capsular tissue of the dislocated IOL-capsular bag complex, and securing the suture to the sclera with a single knot. Preoperative and postoperative uncorrected distance visual acuity (UDVA) and best-corrected visual acuity (BCVA), as well as adverse events, were recorded.</p><p><strong>Results: </strong>A total of 8 eyes from 8 patients were included. The median preoperative uncorrected distance visual acuity (UDVA), expressed as the logarithm of the minimum angle of resolution (logMAR), was 1.3 (range, 1.0-2.0), improving to 0.56 (range, 0-2.3) at the final follow-up. During the postoperative follow-up period (1 month to 1 year), transient ocular hypertension and uveitis occurred in one patient each, with no other significant adverse events observed, including IOL tilt, decentration, pupillary capture, suture exposure, or vision-threatening macular edema.</p><p><strong>Conclusion: </strong>This novel in situ suspension technique for in-the-bag IOL dislocation demonstrates enhanced postoperative uncorrected distance visual acuity, a favourable short-term safety profile, simplified procedural steps with minimally tissue trauma, independence from the type of dislocated IOL, and no requirement for specialized instruments or bio-materials. Future studies with extended follow-up are warranted to validate its long-term efficacy and safety.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"618477"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan Alsetri, Mitchell P Weikert, Nicole Fram, Jared Pagal, Karolinne Maia Rocha, Marcela Feltrin De Barros, Daniel H Chang, Brandon D Ayres, Damien F Goldberg, Jonathan D Solomon, Elizabeth Yeu, John Sheppard
{"title":"Evaluation of Intraocular Lens (IOL) Formulae Utilizing Posterior Corneal Power in Post-Laser Vision Correction (LVC) Eyes.","authors":"Hasan Alsetri, Mitchell P Weikert, Nicole Fram, Jared Pagal, Karolinne Maia Rocha, Marcela Feltrin De Barros, Daniel H Chang, Brandon D Ayres, Damien F Goldberg, Jonathan D Solomon, Elizabeth Yeu, John Sheppard","doi":"10.2147/OPTH.S634188","DOIUrl":"https://doi.org/10.2147/OPTH.S634188","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the accuracy of intraocular lens (IOL) power calculation formulae incorporating posterior corneal power vs traditional keratometry in post-laser vision correction (LVC) eyes undergoing cataract surgery.</p><p><strong>Patients and methods: </strong>This multicenter study (7 sites) combined retrospective chart review and prospective enrollment of adult cataract surgery patients with prior myopic or hyperopic LVC (one study eye per patient). Preoperative biometry was obtained by swept-source optical coherence tomography, and refractive prediction accuracy was compared across six IOL formulae (Barrett True K-AK, Barrett True K-TK, EVO 2.0-AK, EVO 2.0-TK, Haigis-TK, and Shammas-Cooke) in terms of trueness (mean refractive prediction error [RPE]), precision (RPE dispersion), and accuracy (absolute error metrics and proportion of eyes within ±0.5 D and ±1.0 D).</p><p><strong>Results: </strong>A total of 154 eyes were included. The proportion of eyes within ±0.5 D of predicted refraction was highest with EVO 2.0-TK in both post-myopic (77%) and post-hyperopic (88%) LVC eyes, with Barrett True K-TK next highest (75% and 78%, respectively); in post-myopic eyes, EVO 2.0-TK was also the only formula whose mean RPE did not differ significantly from zero.</p><p><strong>Conclusions: </strong>EVO 2.0-TK demonstrated the highest overall accuracy among the formulae evaluated in both post-myopic and post-hyperopic LVC eyes, while Barrett True K-TK also performed well, with both formulae achieving ≥75% of eyes within ±0.50 D in both LVC subgroups.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"634188"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreia Filipa Gomes, Ana Paula Oliveira, Ana Roque, Clara Martinez-Perez
{"title":"Methodological Limitations in \"Self-Reported Vision-Related Quality of Life and Functional Impact in Portuguese Patients with Uveitis: A Cross-Sectional Study\" [Response to Letter].","authors":"Andreia Filipa Gomes, Ana Paula Oliveira, Ana Roque, Clara Martinez-Perez","doi":"10.2147/OPTH.S649864","DOIUrl":"https://doi.org/10.2147/OPTH.S649864","url":null,"abstract":"","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"649864"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ICU-Associated Exposure Keratopathy and Preventable Corneal Blindness: A Clinical Review.","authors":"Abdullahi Abdirahman Omar","doi":"10.2147/OPTH.S632538","DOIUrl":"https://doi.org/10.2147/OPTH.S632538","url":null,"abstract":"<p><p>Exposure keratopathy is an ocular surface injury caused by prolonged corneal exposure, most often from incomplete eyelid closure. Critical illness can intensify exposure through reduced blinking, chemosis, impaired corneal reflexes, sedation, mechanical ventilation, and tear film instability. This narrative clinical review synthesizes contemporary evidence on epidemiology, mechanisms, risk factors, bedside assessment, prevention, protocol implementation, and care in resource-constrained intensive care units (ICUs). PubMed/MEDLINE was searched for English language literature from January 2000 through 15 September 2026, supplemented by reference list and guideline searches. Systematic reviews, randomized trials, cohort studies, quality improvement reports, and relevant guidance were prioritized. Pooled evidence indicates that exposure keratopathy is common among critically ill patients, and recent trials support scheduled lubrication, eyelid closure support, and moisture chamber approaches, particularly when the cornea remains exposed. Fluorescein assessment and clear ophthalmology referral criteria improve detection of epithelial injury and complications that threaten vision. The review distinguishes evidence from randomized and observational studies and proposes a pragmatic bedside risk framework without presenting it as a validated score. Its principal contribution is the integration of prevention, nursing workflow, clinical escalation, and resource appropriate implementation into a single ophthalmic patient safety framework. The intended audience is ophthalmologists, intensivists, ICU nurses, optometrists, and quality improvement teams. Early structured eye care may reduce avoidable corneal morbidity while supporting consistent practice across settings with different resources.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"632538"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jai G Parekh, Christopher M Spearman, J Morgan Micheletti, Inder Paul Singh, Nisha Kumar, Eric Mann, Karolinne Maia Rocha, Eric Donnenfeld
{"title":"Visual, Refractive, and Patient-Reported Outcomes Following Bilateral Implantation of an Enhanced Monofocal IOL: An Exploratory Comparison of Achieved Mini-Monovision and Bilateral Emmetropia.","authors":"Jai G Parekh, Christopher M Spearman, J Morgan Micheletti, Inder Paul Singh, Nisha Kumar, Eric Mann, Karolinne Maia Rocha, Eric Donnenfeld","doi":"10.2147/OPTH.S632198","DOIUrl":"https://doi.org/10.2147/OPTH.S632198","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical and patient-reported outcomes following bilateral implantation of partial-depth-of-field enhanced monofocal IOL in subjects achieving bilateral emmetropia vs mini-monovision.</p><p><strong>Patients and methods: </strong>This prospective, non-interventional, multicenter, cross-sectional study included subjects who had undergone cataract surgery and implantation of enVista Aspire IOL. For the post hoc analysis, patients were classified into bilateral emmetropia (BE) or mini-monovision (MM) based on achieved postoperative manifest refraction. Postoperative assessments included visual outcomes, manifest refraction, defocus curve, contrast sensitivity function, and patient-reported outcomes of questionnaires (AIOLIS and NAVQ).</p><p><strong>Results: </strong>In the BE group (N = 49), the mean MRSE in the first and the second operated eye was -0.18 ± 0.26 D and -0.11 ± 0.26 D, respectively, and the mean UDVA was 0.07 ± 0.11 logMAR and 0.05 ± 0.12 logMAR, respectively. Mean UIVA in the first- and second-operated eyes of the BE group was ~0.23 logMAR, and mean UNVA was ~0.46 logMAR. In the MM group (N = 21), with the mean MRSE of -0.33 ± 0.17 D, the mean UDVA in the distance eye was 0.11 ± 0.12 logMAR. With a mean MRSE of -0.96 ± 0.34 D, mean UIVA and UNVA of the intermediate eye were 0.13 ± 0.09 logMAR and 0.29 ± 0.16 logMAR, respectively. The defocus curve showed 0.2 logMAR or better visual acuity up to a myopic defocus of ~-1.25 D. A higher proportion (~14 to 31%) of subjects in the MM group reported \"no or little difficulty\" with various intermediate- to near-vision-related tasks. The frequency and bothersomeness of visual symptoms were similar between the two groups. A total of 85.7% of subjects in the MM group were \"completely to very satisfied\" with their overall postoperative vision compared to the BE group (77.6%).</p><p><strong>Conclusion: </strong>The MM group demonstrated improved intermediate and near visual performance and favorable patient-reported outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"20 ","pages":"632198"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}