Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Visual and Refractive Outcomes of a New Monofocal, Non-Constant Aberration-Correcting Aspheric Intraocular Lens.","authors":"Smita Agarwal, Erin Thornell","doi":"10.2147/OPTH.S538686","DOIUrl":"10.2147/OPTH.S538686","url":null,"abstract":"<p><strong>Purpose: </strong>To assess early visual and refractive outcomes of the CT Lucia 621PY intraocular lens (IOL).</p><p><strong>Methods: </strong>Retrospective analysis was performed for 47 consecutive eyes from 33 patients following routine phacoemulsification and implantation of CT Lucia 621PY monofocal IOLs for the treatment of cataract. Postoperative analysis was performed 6-weeks following surgery. Uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BCVA) and manifest refraction were measured for all patients. Uncorrected mesopic contrast sensitivity (CS) was measured for a subset of 22 of the 47 eyes, and modulated transfer function (MTF) and angle alpha and angle kappa were measured for a separate subset of 19 eyes.</p><p><strong>Results: </strong>Mean spherical equivalent (SE) was -0.04±0.38 D, with 83% of eyes achieving within ±0.5 D of the refractive target. Mean UDVA was 0.05±0.1 LogMAR at 6 weeks postoperative, with 98% of eyes achieving 0.2 LogMAR or better. Mean BCVA was -0.02±0.06 LogMAR, with 87% of eyes achieving 0.00 LogMAR or better. Mean mesopic monocular CS was 1.4±0.26 sec arc, and 50% contrast was maintained at a spatial frequency of approximately 13 cycles per degree. There was no significant correlation between MTF and angle alpha or angle kappa.</p><p><strong>Conclusion: </strong>The CT Lucia 621PY offers good visual and refractive outcomes. While there was no significant correlation between angle alpha or angle kappa and visual quality, further investigation is warranted.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3439-3447"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Duke Baerveldt 350 Versus Ahmed ClearPath 350 Study (DBACS): A Randomized Control Trial In Adults With Medically Refractory Glaucoma.","authors":"Michael S Quist, Andrew W Gross, Nicholas A Johnson, Sandra S Stinnett, Joanne C Wen, Pratap Challa, Kelly W Muir, Frank Moya, Leon W Herndon","doi":"10.2147/OPTH.S523294","DOIUrl":"10.2147/OPTH.S523294","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety profile of two non-valved glaucoma drainage devices (GDDs).</p><p><strong>Patients & methods: </strong>In this randomized control trial, patients with medically refractory glaucoma needing surgical intervention were randomized for placement of a Baerveldt 350 (BVT) or an Ahmed ClearPath 350 (ACP). Baseline testing included measures of visual acuity, intraocular pressure (IOP), medication, visual fields, and optical coherence tomography. IOP, medication use, and complications were assessed at post-operative day one, week one, week four, week six, month three, month six, and year one.</p><p><strong>Results: </strong>A total of 76 subjects were enrolled, 37 randomized to BVT and 39 to ACP. A total of 70 subjects underwent surgery and 61 subjects were seen to one year of follow-up. No significant differences were observed in age, sex, race, eye laterality, glaucoma type, glaucoma severity, prior surgeries, and baseline IOP (p = 0.66, 0.10, 0.70, 0.48, 0.06, 0.65, 0.50, 0.56 respectively), between the groups. At one year, both groups showed significant reductions in IOP, though the ACP group showed lower mean IOP at 12 months (11.4 vs 14.1 mmHg, p = 0.010) as well as a larger IOP decrease compared to baseline (-44.1 vs -30.7%, p = 0.038). Medication usage remained similar in both groups. Complications were infrequent and comparable between the devices. This study did not reach the number of subjects thought to be needed to power the study appropriately; despite the enrollment numbers, statistically significant differences were noted, and no type II occurred for the primary endpoint of mean IOP.</p><p><strong>Conclusion: </strong>While both GDDs demonstrated efficacy over a 1-year period, ACP showed a lower mean IOP and greater IOP percentage decrease from baseline compared to BVT. Both exhibited low complication rates. Further research over a longer follow-up is warranted to explore the IOP differences.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3449-3463"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Prevalence and Severity of Isolated Small-Angle Strabismic Amblyopia.","authors":"Robert W Arnold","doi":"10.2147/OPTH.S546692","DOIUrl":"10.2147/OPTH.S546692","url":null,"abstract":"<p><strong>Background: </strong>Isolated small-angle (< 20PD) strabismic amblyopia (is-asa) is not obvious to parents and pediatricians and can be missed by current photoscreeners. To improve early screening methods, the previously unknown prevalence and severity of is-asa is estimated from a twenty-year prospective observation.</p><p><strong>Methods: </strong>Published population data from the Multi-Ethnic and Baltimore Pediatric Eye Disease Studies (MEPEDS and BPEDS) were combined to estimate the cumulative prevalence. Then prospective, consecutive digital images of Brückner Test from 2003 to 2025 by one pediatric ophthalmologist were obtained with confirmatory exams. These were then compared to Alaska population and vision screening data.</p><p><strong>Results: </strong>From MEPEDS and BPEDS community screening data, patients with all strabismus, constant strabismus and strabismic amblyopia were stratified by strabismus angle suggesting that isolated small-angle strabismus (is-as) may occur in 1/200 children while is-asa may be 1/400 children. Over 22 years, 34 Alaska Brückner patients had isolated, constant strabismus less than 20 prism diopters of which 9 presented with amblyopia of which 4 had post-treatment residual amblyopia worse than 20/40. Considering population, doctors and referral rates, the Alaska prevalence of is-as is about 1 in 700 (0.03-0.24%) children while is-asa is about 1 in 7000 (0.006-0.024%) children.</p><p><strong>Conclusion: </strong>From two imperfect sources; review of large community screening studies and from prospective Brückner Test analysis, the prevalence of isolated small-angle strabismic amblyopia is so rare that future screening methods would require very high specificity. The Rebion blinq and 2WIN CR-function can identify is-asa in older children. Current photorefraction methods with early specific instrument referral criteria followed by sensitive acuity screening are still effective since is-asa is so rare.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3409-3418"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Robotic Laser Arcuate Keratotomy and Toric Intraocular Lenses for the Management of Lower Magnitude Astigmatism at the Time of Cataract Surgery.","authors":"Gary Wortz, Preeya K Gupta, Jacob R Weinstock","doi":"10.2147/OPTH.S543462","DOIUrl":"10.2147/OPTH.S543462","url":null,"abstract":"<p><strong>Purpose: </strong>To compare refractive and visual outcomes between robotic laser-assisted arcuate keratotomy (AK) guided by the Wörtz-Gupta Formula^TM and low-power toric intraocular lens (IOL) implantation using the Barrett Toric Calculator for the management of low-magnitude regular corneal astigmatism during cataract surgery.</p><p><strong>Patients and methods: </strong>This retrospective, single-surgeon case series included 105 eyes with robotic laser-assisted AK using the ALLY platform with iris registration (LENSAR, Inc, Orlando, FL), and 53 received a toric IOL, using ALLY's IntelliAxis refractive capsulorhexis for intraoperative toric IOL alignment. The primary outcome measure was postoperative residual refractive cylinder at postoperative week 4. Secondary outcomes included uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (CDVA), and spherical equivalent (SE) refraction. Subgroup analyses evaluated outcomes by astigmatism orientation (with-the-rule [WTR] versus against-the-rule [ATR]).</p><p><strong>Results: </strong>Postoperative residual refractive cylinder did not differ significantly between groups (-0.14 ± 0.16 D AK vs -0.21 ± 0.28 D toric, <i>p</i> = 0.103), nor did SE refraction (-0.08 ± 0.32 D AK versus -0.11 ± 0.28 D toric, <i>p</i> = 0.361), UDVA (0.05 ± 0.08 logMAR both groups, <i>p</i> = 0.507), or CDVA (-0.006 logMAR AK versus -0.004 logMAR toric, <i>p</i> = 0.623). More than 90% of eyes in both cohorts achieved ≤0.50 D of residual astigmatism, and ≥87% attained UDVA of 20/25 or better. Subgroup analyses by astigmatism orientation showed no statistically significant differences in residual cylinder, SE, or VA.</p><p><strong>Conclusion: </strong>In eyes with low-magnitude regular corneal astigmatism undergoing cataract surgery, robotic laser-assisted AK guided by the Wörtz-Gupta Formula^TM achieved non-infereior refractive and visual outcomes to those of low-power toric IOL implantation.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3401-3408"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Topical Non-Selective and COX-2 Selective NSAIDs in Accelerating Resolution of Acute Central Serous Chorioretinopathy: A Retrospective Analysis.","authors":"Preston O'Brien, Michael A Singer, Darren J Bell, Abigail Diamond, Allison Kim, Ella H Leung, David S Chin Yee, Rishi P Singh, Andrew N Antoszyk","doi":"10.2147/OPTH.S540294","DOIUrl":"10.2147/OPTH.S540294","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether topical nonsteroidal anti-inflammatory drugs (NSAIDs) accelerate the resolution of acute central serous chorioretinopathy (CSCR) compared with observation.</p><p><strong>Patients and methods: </strong>This retrospective cohort study reviewed patients diagnosed with acute CSCR (2018-2023) (n = 145). Patients received either topical ketorolac (n = 26, nonselective NSAID, four times daily) or observation alone (n = 63). Historical data (2007-2013) (n = 111) comparing COX-2 selective NSAIDs (bromfenac or nepafenac, n = 38) with observation (n = 73) were analyzed for comparison. Main outcome was time to complete subretinal fluid resolution on optical coherence tomography (OCT) and visual acuity (VA) recovery to 20/20. Outcomes were analyzed using Kaplan-Meier survival curves and Cox proportional-hazards regression.</p><p><strong>Results: </strong>Baseline demographics were similar between NSAID-treated and observed groups (mean age 45 years, ~82% male, baseline visual acuity ~20/40). In the recent cohort, NSAID treatment with ketorolac significantly accelerated fluid resolution compared with observation (median 74 vs 115 days; hazard ratio 1.70, 95% CI 1.05-2.75, p = 0.033). Historical data revealed a greater treatment effect with COX-2 selective NSAIDs (mean resolution 42 days vs 131 days with observation, p < 0.0001). When combined, NSAIDs significantly shortened CSCR duration compared to observation alone (mean 62 vs 132 days, p < 0.001), with COX-2 selective NSAIDs showing superior efficacy (p < 0.01 vs ketorolac). Visual acuity outcomes at final resolution were excellent (~20/20) and similar between groups. No significant adverse events occurred, and 12-month recurrence rates were similar between NSAID-treated and observed groups.</p><p><strong>Conclusion: </strong>Topical NSAIDs, especially COX-2 selective agents, may accelerate resolution of acute CSCR compared to observation alone. The earlier recovery of normal vision and anatomical resolution may benefit patients clinically by reducing morbidity associated with prolonged retinal detachment. Prospective studies are warranted to confirm these findings and refine treatment protocols for acute CSCR.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3389-3400"},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Operative Outcomes at One Year of STREAMLINE Microinvasive Glaucoma Surgery Combining Micro-Goniotomy and Focal Ab-Interno Canaloplasty.","authors":"Meghan Sharma, Catherine Johnson, Cameron Michael Carpenter, Blessing S Ofori-Atta, Ben J Brintz, Ashley Polski, Austin S Nakatsuka","doi":"10.2147/OPTH.S532731","DOIUrl":"10.2147/OPTH.S532731","url":null,"abstract":"<p><strong>Purpose: </strong>The STREAMLINE Surgical System performs microinvasive glaucoma surgery (MIGS) by creating micro-goniotomy incisions in the trabecular meshwork with focal ab-interno canaloplasty of Schlemm's canal. This retrospective review examines the procedure's effect on intraocular pressure (IOP) and number of glaucoma medications throughout one post-operative year.</p><p><strong>Methods: </strong>All cases at the John A. Moran Eye Center with Current Procedural Terminology codes 65820 and 66174 were searched for STREAMLINE cases from October 2021 to May 2024. Eyes were excluded if the case was combined with another procedure other than phacoemulsification, did not include both goniotomy and ab-interno canaloplasty, or was a standalone STREAMLINE procedure without phacoemulsification. Demographic data and baseline number of medications and IOP were recorded. IOP measurements were recorded on post-operative day 0, week 1, month 1, month 3, month 6, month 9, and month 12. Number of medications was recorded post-operatively at 6 months and 12 months. Linear mixed effects models were fit to estimate IOP at each follow-up time while accounting for within-eye correlation.</p><p><strong>Results: </strong>Thirty-nine eyes that underwent the procedure were included from 29 patients of ages 18-86. The average IOP decrease from baseline IOP was 0.68 mmHg on post-operative day 0 (p=0.52), 1.49 mmHg at post-operative month 1 (p=0.16), 1.67 mmHg at post-operative month 3 (p=0.17), 1.62 mmHg at post-operative month 6 (p=0.18), 1.05 mmHg at post-operative month 9 (p=0.36), and 1.87 mmHg at post-operative month 12 (p=0.13). There was a post-operative IOP increase of 0.18 mmHg at post-operative week 1 (p=0.88). The average number of glaucoma medications was reduced by 47% at 6 months post-operatively (p<0.001) and 48% at 12 months (p=0.003).</p><p><strong>Conclusion: </strong>In a retrospective review of 39 eyes at one institution, STREAMLINE goniotomy and ab-interno canaloplasty significantly decreased the number of glaucoma medications one year after surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3381-3387"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Maternal Pre-Pregnancy Body Mass Index and Astigmatism and Corneal Curvature in Offspring: A Cross-Sectional Study.","authors":"Yuanyuan Han, Hongyu Lv, Yidan Cao, Jing Wu, Xiaoyu Zeng, Emmanuel Eric Pazo, Yaxin Zhao, Jia Lv, Wenli Lu, Xuehan Qian, Nan Wei","doi":"10.2147/OPTH.S532009","DOIUrl":"10.2147/OPTH.S532009","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between maternal pre-pregnancy body mass index (BMI) and astigmatism and corneal curvature in offspring.</p><p><strong>Patients and methods: </strong>Corneal topography and an optical biometer were used to measure ocular parameters, while cycloplegic autorefraction was performed to assess cylindrical diopter and axis. Demographic, pregnancy, and offspring-related information was collected through questionnaires. Multiple linear regression analyses were conducted to evaluate the association.</p><p><strong>Results: </strong>A total of 213 mother-child pairs were included. Maternal pre-pregnancy BMI was categorized as underweight (11.3%), normal weight (66.7%), overweight (16.0%), and obese (6.1%). The mean age of the offspring was 6.80 ± 2.44 years (males 49.3%). Offspring born to mothers with overweight or obese pre-pregnancy BMI exhibited significantly higher steep corneal curvature, average corneal curvature, corneal astigmatism, and total astigmatism compared to those in the normal pre-pregnancy BMI group. In multiple linear regression analysis, after adjusting for relevant covariates, pre-pregnancy BMI was positively associated with steep corneal curvature (β=0.35, P=0.005), corneal astigmatism (β=0.21, P=0.001), and total astigmatism (β=0.22, P<0.001). Compared to normal pre-pregnancy BMI, pre-pregnancy obesity was positively associated with offspring steep corneal curvature (β=1.52, P=0.002) and those born to mothers with overweight or obese pre-pregnancy BMI had a significantly higher prevalence of corneal astigmatism (overweight: β=0.56, P=0.001; obese: β=0.55, P=0.038) and total astigmatism (overweight: β=0.47, P=0.002; obese: β=0.59, P=0.010).</p><p><strong>Conclusion: </strong>Offspring of mothers with overweight or obese pre-pregnancy BMI show higher prevalence of developing corneal and total astigmatism compared to the normal.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3371-3380"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Collagen Crosslinking in Patients with Keratoconus and Co-Existent Limbal Stem Cell Deficiency.","authors":"Rashmi Deshmukh, Eeshita Agarwal, Swapna Shanbhag, Rasik B Vajpayee","doi":"10.2147/OPTH.S548579","DOIUrl":"10.2147/OPTH.S548579","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse the outcomes of collagen crosslinking (CXL) in eyes with progressive keratoconus (KC) and secondary limbal stem cell deficiency (LSCD) caused by vernal keratoconjunctivitis (VKC).</p><p><strong>Methods: </strong>Patients with progressive KC and VKC having co-existent LSCD who underwent CXL from May 2016 to October 2023 were included. Demographic details, clinical and corneal topography data were collected preoperatively, at 1-months, 3-months, 6-months and 1-year. Details of the CXL procedure and early postoperative complications were noted. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and topographic indices including flattest keratometry (K1), steepest keratometry (K2), mean keratometry (Km), maximum keratometry (Kmax) and thinnest corneal thickness (TCT) were noted at 1-year and compared with the preoperative data.</p><p><strong>Results: </strong>Fifteen eyes of 11 patients were included in the study. Partial LSCD was present in 14 eyes and underwent epithelium-off CXL and 1 eye with total LSCD underwent transepithelial CXL. The mean logarithm of the minimum angle of resolution (logMAR) UCVA pre-CXL was 0.67±0.38 which improved to 0.54±0.32 at 6-months (p=0.05) and 0.65±0.35 logMAR at 1-year post-CXL (p = 0.005). Pre-CXL Km was 53.5±4.77 (median-51.95D) which decreased to post-cxl value of 51.72±3.65 at 6-months (p=0.014) and 52.34±3.83 (median-51.3D) at 1-year (p=0.09). Kmax reduced from 63.41±7.11 (median-63.7D) pre-CXL to 60.65±5.31 (median-59.6) (p=0.05) at 6-months and 61.4±6.01 (median-61.9D) at 1-year post-CXL (p=0.115). Of the 14 eyes that underwent epi-off CXL, 2 eyes (14.28%) had persistent epithelial defects (PEDs), one of which needed amniotic membrane graft (AMG).</p><p><strong>Conclusion: </strong>In our series, most eyes with keratoconus having co-existent LSCD had uncomplicated ocular surface healing post-CXL and remained stable at 1-year with significant improvement in visual acuity. Our study shows that CXL can be successfully performed in cases of Keratoconus with co-existing LSCD without any serious complications.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3357-3362"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Reported Visual Outcomes, Dry Eye Symptoms, and Satisfaction Following Topography-Guided LASIK.","authors":"Phillip B Brunson, Paul M Mann Ii, Brad Hall","doi":"10.2147/OPTH.S542097","DOIUrl":"10.2147/OPTH.S542097","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the subjective satisfaction, visual disturbances, and dry eye symptoms following Phorcides planned Contoura topography-guided LASIK.</p><p><strong>Methods: </strong>This was a single site, single arm, prospective study of patient reported outcomes after bilateral Phorcides planned Contoura topography-guided LASIK. Preoperative and postoperative data were collected for responses on the Patient-Reported Outcomes with LASIK Symptoms and Satisfaction (PROWL-SS) questionnaire (a lower score represented a worse outcome), Ocular Surface Disease Index (OSDI) questionnaire (a higher score represented a worse outcome), refraction, and visual acuity. Linear mixed effect models were used to compare preoperative and postoperative scores on the PROWL-SS for satisfaction, and the frequency, bothersomeness, and visual impact of glare, halo, starbursts, and double images.</p><p><strong>Results: </strong>A total of 50 subjects completed the study. Mean age was 29.3 ± 5.0 years (range 20 to 39 years). The mean 3-month postoperative satisfaction score was 53.2 higher than the mean preoperative score (p <0.0001). Mean 3-month postoperative scores were 7.4, 13.7, 18.0, and 29.2 higher postoperatively compared to preoperatively for double image, glare, halo, and starburst, respectively. All differences were significant (p <0.0001) with the exception of double image. Mean score on the OSDI questionnaire was 27.0 ± 22.4 preoperatively, compared to 7.5 ± 6.7 at 3 months postoperatively (p <0.0001). Postoperatively, 97% of eyes (90/100) had MRSE within ± 0.5 D and postoperative residual astigmatism was ≤ 0.5 D in 96% of eyes (96/100). Postoperative UDVA was 20/20 or better in 98% (98/100) of eyes, 20/16 or better in 81% (81/100) of eyes, and 20/12.5 or better in 31% (31/100) of eyes.</p><p><strong>Conclusion: </strong>The results of this study suggest improved patient reported satisfaction, reduced dry eye symptoms, and overall decrease in visual disturbances at 3 months following Phorcides planned Contoura LASIK.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3363-3369"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Phacoemulsification Safety: How Low Fluidic Settings Influence Active Surge Mitigation Actuation.","authors":"Biljana Kuzmanović Elabjer, Tea Štrbac, Iva Ćubela, Mladen Bušić, Mirjana Bjeloš","doi":"10.2147/OPTH.S539817","DOIUrl":"10.2147/OPTH.S539817","url":null,"abstract":"<p><strong>Introduction: </strong>Active Surge Mitigation (ASM) is a feature of the Centurion Vision System ACTIVE SENTRY^® Handpiece designed to minimize post-occlusion surge by dynamically adjusting fluidics. Stable anterior chamber conditions are critical during phacoemulsification, and low intraocular pressure (IOP) fluidics may enhance surgical safety by reducing stress on ocular tissues. This study evaluated demographic, biometric, and intraoperative factors influencing ASM activation during phacoemulsification at low IOP settings (30 mmHg), a vacuum of 575 mmHg, and an aspiration flow of 28 cc/min.</p><p><strong>Methods: </strong>This retrospective study was conducted at the University Eye Clinic, University Hospital \"Sveti Duh\" in Zagreb, Croatia, between January 19 and April 12, 2024. Preoperative parameters included age, gender, biometric data from the Zeiss IOL Master 700, and lens hardness, classified according to the Lens Opacities Classification System (LOCS III). The presence of Pseudoexfoliation Syndrome (PEX) and Intraoperative Floppy Iris Syndrome (IFIS) was noted. Intraoperative metrics recorded were total case time, cumulative dissipated energy (CDE), ultrasound time (U/S time), and the number of ASM actuations.</p><p><strong>Results: </strong>ASM actuations were not normally distributed (median = 1; mean = 2.4). Significant positive correlations were identified with age (P = 0.014), lens thickness (P = 0.039), and U/S time (P = 0.015), while no significant differences were observed for anterior chamber depth (ACD), gender, PEX, or IFIS. Logistic regression identified age as a predictor of ASM values ≥1.</p><p><strong>Conclusion: </strong>At low IOP settings, surge events during phacoemulsification are rare. ASM activation is influenced by patient age, lens thickness, and U/S time but not by ACD, gender, PEX, or IFIS. Low IOP fluidics combined with ASM contributes to stable and safe chamber dynamics across diverse patient profiles.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3331-3338"},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}