Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"A Prospective Single-Center Clinical Trial Comparing Short-Term Outcomes of a Novel Non-Cavitating Handheld Lensectomy Device versus Phacoemulsification.","authors":"Nathan T Cannon, Kathleen Scruggs, Seth M Pantanelli","doi":"10.2147/OPTH.S522334","DOIUrl":"10.2147/OPTH.S522334","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the short-term outcomes of a non-cavitating lensectomy device (MICOR) to phacoemulsification.</p><p><strong>Patients and methods: </strong>This was a two-arm prospective open-label clinical trial. Patients with visually significant cataracts at a single academic center between March and December 2023 were consecutively enrolled to undergo cataract surgery using either MICOR or phacoemulsification for nuclear fragmentation and lens removal. Adverse events (AE), lensectomy time, fluid use, and ultrasound energy use were assessed intraoperatively. Visual acuity, refraction, and AE were assessed on postoperative day one.</p><p><strong>Results: </strong>A total of 34 eyes of 23 patients were included in the MICOR arm and 50 eyes of 32 patients in the phacoemulsification arm. No difference (p = 0.727) in logMAR best corrected distance visual acuity was observed postoperatively between MICOR (0.14 ± 0.25) and phacoemulsification (0.16 ± 0.33), nor was any difference observed in AE rates [3% versus 8%, respectively (p = 0.644)]. Lens removal time was faster with MICOR [209 vs 255 s (p = 0.003)], including for grade 2 cataracts [203 vs 237 s (p = 0.008)]. Irrigation volume was less for MICOR [33 vs 62 mL (p < 0.001)], including for grade 2 [34 vs 60 mL (p < 0.001)] and 3 cataracts [36 vs 60 mL (p = 0.004)]. Mean cumulative dissipated energy for phacoemulsification was 8.7.</p><p><strong>Conclusion: </strong>Compared to phacoemulsification, MICOR has similar visual outcomes and adverse event rates while requiring less time, irrigation fluid, and ultrasound energy, suggesting MICOR is a viable alternative to phacoemulsification.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2281-2288"},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Four Hours of Continuous Personal Computer (PC) Gaming on the Development of Dry Eye Symptoms in College Students.","authors":"Derrick Liu, Bernard L Cook Iii, Edmund P Farris","doi":"10.2147/OPTH.S530620","DOIUrl":"10.2147/OPTH.S530620","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate if a short period of playing video games on a personal computer (PC) causes changes in measurements of dry eye disease (DED).</p><p><strong>Patients and methods: </strong>We recruited 41 Quinnipiac University students (ages 18-23 years, mean age 19.66±1.09 years; 9 females, 32 males), with eligibility criteria being 18+ years old, identifying as \"gamers\" without previous history of eye surgery, steroid use, autoimmune disorders, or history of or previous treatment for dry eye. Each student was administered DED-related assessments before/after four hours of continuous PC gaming: 1) Standardized Patient Evaluation of Eye Dryness (SPEED) and Ocular Surface Disease Index (OSDI) questionnaires, 2) Snellen visual acuity test, 3) tear osmolarity point-of-care assay, 4) matrix metalloproteinase-9 (MMP-9) inflammation point-of-care assay, and 5) an unanesthetized Schirmer test of tear production. Students were limited to 500 cc of water during the four hour period.</p><p><strong>Results: </strong>Following gaming, the mean SPEED scores increased significantly (p<0.001, Wilcoxon signed-rank test), as did the frequency and severity of soreness/irritation and eye fatigue. Tear osmolarity decreased and tear production increased in the right eye. Other metrics (OSDI, Snellen, and MMP-9) did not change significantly.</p><p><strong>Conclusion: </strong>As little as four hours of continuous PC gaming with limited hydration results in an increase in self-reported measures of DED symptoms. These prospective findings corroborate the epidemiological link between gaming and DED symptoms and highlight the need for long-term studies.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2229-2238"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Outcomes and Complication Rates of Cataract Surgery in Asian High Myopic Patients: A Meta-Analysis and Systematic Review.","authors":"Ke-Bing Zhao, Jing-Shang Zhang, Xiu-Hua Wan","doi":"10.2147/OPTH.S532853","DOIUrl":"10.2147/OPTH.S532853","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the visual outcomes and complication rates of cataract surgery in high myopic patients through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>Following the PRISMA 2020 guidelines, a comprehensive literature search was conducted across multiple databases to identify studies reporting on cataract surgery outcomes in highly myopic patients. Eight studies, involving 1,996 patients (2,826 eyes), were included in the meta-analysis. Data on pre- and postoperative best-corrected visual acuity (BCVA), intraoperative and postoperative complications, and study characteristics were extracted. Random-effects models were used to calculate pooled estimates due to significant heterogeneity among studies.</p><p><strong>Results: </strong>Cataract surgery significantly improved BCVA in high myopic patients, with an average improvement of -1.72 logMAR units (95% CI: -2.37 to -1.06). Substantial heterogeneity was observed across studies (I² = 84.4%, 95% CI: 65.2%-93.1%). Intraoperative and postoperative complications occurred at the following pooled incidences: transient intraocular pressure (IOP) elevation 13.03% (95% CI, 9.59%-17.47%), posterior capsule opacification (PCO) at 12.11% (95% CI, 4.00%-31.30%), cystoid macular edema (CME) at 2.41% (95% CI, 0.84%-6.76%), intraoperative posterior capsule rupture (PCR) at 2.01% (95% CI, 0.89%-4.44%), retinal detachment (RD) at 1.97% (95% CI, 1.21%-3.21%), retinal breaks at 1.89% (95% CI, 0.85%-4.14%) and intraocular lens (IOL) dislocation at 0.67% (95% CI, 0.21%-2.04%).</p><p><strong>Conclusion: </strong>Cataract surgery is effective in improving vision in highly myopic patients but is associated with a moderate risk of complications. The high heterogeneity among studies underscores the need for standardized methodologies and more comprehensive assessments of ocular health in future research. These findings provide valuable insights for optimizing clinical management and enhancing patient counseling.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2239-2248"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double C-Loop Haptic Lenses Are Rotationally Stable - A Systematic Review.","authors":"Sheraz Daya, Christophe Chassain, Christophe Pagnoulle","doi":"10.2147/OPTH.S536114","DOIUrl":"10.2147/OPTH.S536114","url":null,"abstract":"<p><p>The purpose of this review is to summarize the clinical rotational stability outcomes reported in patients following implantation of the POD platform with double C-loop haptics. A literature search in PubMed (US National Library of Medicine) was carried out to find publications, both prospective and retrospective, which report rotational stability outcomes in patients who were implanted with this platform after cataract or refractive lens exchange surgeries. This platform is used in different commercially available intraocular lenses (IOLs), both monofocal and trifocal, made of hydrophilic or hydrophobic material. 19 clinical peer-reviewed studies published between 2013 and 2024 were included in this review. The data reported in the clinical publications was analyzed in detail, focusing on rotational stability (mean rotation values and ranges, and percentage of eyes with some degrees of rotation), measurement methods and rotation follow-up period. Our review encompassed a total of 1428 eyes implanted with the POD platform analyzed at different follow-up periods, up to a maximum of 26 months. The mean rotation across all the studies was 2.61 °.The analysis carried out in this review leads us to conclude that the POD platform provides good rotational stability when used with different IOL models based on monofocal or trifocal designs and made using hydrophilic or hydrophobic material.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2259-2269"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Open Globe Injury in Children at a Tertiary Hospital in Jordan.","authors":"Mohammad Saleh Abu-Ain, Motasem Mohammad Al-Latayfeh, Raed Shatnawi, Mohammad Irfan Khan","doi":"10.2147/OPTH.S399325","DOIUrl":"10.2147/OPTH.S399325","url":null,"abstract":"<p><strong>Purpose: </strong>To study the epidemiology of open globe injury (OGI) in children and highlight the risk factors associated with these injuries and suggest targeted protocols and strategies to minimise its occurrence.</p><p><strong>Methods: </strong>A retrospective analysis of all paediatric OGI cases presenting to our unit between Jan 2014 and Jan 2018. Clinical records were reviewed, and demographic data was collected and analysed for age, gender, place of occurrence, mechanism of injury, type of trauma, and direct cause of injury. Clinical data including presenting visual acuity, type of injury, number of operations, complications, and final visual acuity were also recorded.</p><p><strong>Results: </strong>A total of 67 cases were identified, but 8 cases were excluded due to lack of complete data. Fifty-nine eyes of 59 patients were included, of whom 31 (53%) involved the left eye and 46 patients were males (78%). The mean presenting vision was 1.7 ± 1.05 Log MAR (Median 1.8; IQR 2.2), and the mean vision at 12 months was 0.8 ± 1.13 Log MAR (Median 0.3; IQR 0.7) with the difference being statistically significant (P < 0.001). Mean age was 9.34 ± 4.35 (range 3-16) years and, in most cases (78%), the mechanism of injury was due to a sharp object. The most common places where injuries occurred were home settings (42%) and neighbourhood areas (36%), whereas schools were not found to be common places for injury.</p><p><strong>Conclusion: </strong>We identified epidemiological features of OGI in children in our community that may help local authorities and health education teams reduce its incidence. Discouraging the use of sharp objects by young children, especially in home settings, requires more public awareness strategies. Community and healthcare services may consider these findings useful for implementing local strategies and protocols to prevent and reduce the occurrence of such devastating injuries.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2271-2279"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracorneal Ring Segments in Keratoconus: A Narrative Literature Review.","authors":"Usman K Hayat, Haaris A Shiwani, Danyal Memon, Andrew Walkden","doi":"10.2147/OPTH.S520174","DOIUrl":"10.2147/OPTH.S520174","url":null,"abstract":"<p><strong>Background: </strong>Keratoconus is a bilateral, non-inflammatory corneal ectasia characterized by progressive thinning and conical protrusion, leading to irregular astigmatism, usually in association with high myopia. Visual rehabilitation options include corneal collagen cross-linking (CXL), rigid gas permeable contact lenses, intracorneal ring segments (ICRS), phakic intraocular lenses, and corneal transplantation. ICRS are synthetic, biocompatible implants or allogenic corneal tissue, designed to reduce corneal curvature and optimize the refractive profiles. Initially used in 1978 to treat myopia, their role in keratoconus was established in 2000. This review explores ICRS types, surgical techniques, and emerging developments.</p><p><strong>Methods: </strong>A literature review was conducted using PubMed. A total of 117 peer-reviewed manuscripts, including review articles, randomized controlled trials, case series, and reports, were analysed. Reference lists of publications were also reviewed.</p><p><strong>Results: </strong>ICRS types include MyoRings, KeraRings, Ferrara Rings, and Intacs, each with unique design characteristics and implantation methods. Corneal allogenic intrastromal ring segments represent the latest innovation in ICRS. Femtosecond laser-assisted tunnel creation offers improved control over stromal depth and uniformity, reducing complications compared to mechanical dissection. Studies indicate slight corneal stiffening post-ICRS implantation, with no significant changes in intraocular pressure. Topographic changes post-ICRS show significant corneal flattening and reduction in astigmatism. Complications include epithelial defects, segment migration, and keratitis, but long-term follow-up reveals low rates of serious adverse events.</p><p><strong>Conclusion: </strong>ICRS provide an effective option for enhancing vision in select keratoconus patients, ultimately lowering the chances of requiring a corneal transplant. They are of particular use in those intolerant to contact lenses and without central corneal scarring. Future research should focus on long-term outcomes. Combining ICRS with other procedures like CXL may enhance outcomes, though careful patient selection is crucial.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2249-2257"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Park Table - Augmented and Standard Surgical Doses in Acute Acquired Comitant Esotropia: A Retrospective Analysis.","authors":"Worapot Srimanan","doi":"10.2147/OPTH.S530750","DOIUrl":"10.2147/OPTH.S530750","url":null,"abstract":"<p><strong>Purpose: </strong>Acquired comitant esotropia (ACE) is a rare condition characterized by the sudden onset of inward eye deviation. In non-recovered cases, surgery was performed. The standard surgical dose typically leads to undercorrection, and multimodal approaches were used to enhance outcomes. The current study aimed to explore the clinical course and identify factors influencing surgical success in patients with ACE at a tertiary hospital.</p><p><strong>Patients and methods: </strong>This retrospective study reviewed the electronic medical records of 99 patients diagnosed with ACE at Phramongkutklao Hospital between 2014 and 2024. Data collected included patient demographics, underlying etiologies, clinical presentations, treatment approaches, and surgical outcomes. Surgical cases were categorized based on the use of either the standard Park surgical dosage or an augmented dose, defined as an additional 0.5 mm beyond the standard amount. Factors associated with successful surgical outcomes were also evaluated through statistical analysis.</p><p><strong>Results: </strong>The mean age at diagnosis was 28.97 ± 19.67 years, with a slight predominance of men. ACE was classified as types I (Swan type), II (Burian-Franceschetti), and III (Bielschowsky) in 8.08% (8/99), 46.46% (46/99), and 45.45% (45/99), respectively. All cases were idiopathic, with neuroimaging abnormalities detected in 4.04% (4/99) of patients. Surgical intervention was required in 79.8% (79/99) of cases. One year postoperatively, 75% (54/72) of patients demonstrated substantial improvement in ocular alignment. Based on subgroup analysis, the success rate was 91.18% in the augmented group and 60.53% in the non-augmented group. Logistic regression analysis indicated that an augmented surgical dose was significantly associated with favorable surgical outcomes (adjusted odds ratio: 5.50; 95% confidence interval [95% CI], 1.32-22.89).</p><p><strong>Conclusion: </strong>This study demonstrates a high surgical success rate in patients with ACE, supporting the potential use of augmented surgical doses. Further research is warranted to identify additional prognostic factors and refine treatment strategies for optimal ACE management.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2211-2220"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Tear Film Stability and Myopia in Children.","authors":"Pei-Wei Huang, Yu-Kai Kuo, Nan-Ni Chen, Ju-Hsien Li, Cheng-Hsiu Wu, Ho-Min Chen, Kuan-Wen Su, Chi-Chin Sun","doi":"10.2147/OPTH.S527012","DOIUrl":"10.2147/OPTH.S527012","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between dry eye and myopia in Taiwanese school children.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled children aged 5-14-years-old between January 2021 and April 2022. The Ocular Surface Disease Index (OSDI) and an activity questionnaire were used to assess the severity of dry eye and the children's lifestyle. Dry eye was assessed using Schirmer's I test, tear break-up time (TBUT), corneal fluorescein staining, and the lid abnormality score. The correlation between dry eye and myopia was determined by linear regression analysis.</p><p><strong>Results: </strong>In total, 31 non-myopic (mean age, 9.03 years) and 34 myopic (mean age, 8.44 years) children were included in the final analysis. Children with myopia had a significantly higher mean OSDI than children without myopia (4.79 ± 6.90 versus 1.68 ± 3.46, <i>P</i> = 0.024). The prevalence of dry eye disease was higher in myopic children (11.7%) than non-myopic children (3.2%) without significant difference. There were no significant differences in the Schirmer test, TBUT, corneal fluorescein staining score, or lid abnormality score between groups. Multiple regression analyses showed the OSDI was significantly associated with more negative spherical power (regression coefficient [B] = -0.74, 95% confidence interval = -1.48 to -0.01, <i>P</i> = 0.048) and presence of myopia (B = 3.44, 95% CI = 0.72 to 6.16, <i>P</i> = 0.014) after adjusting for age.</p><p><strong>Conclusion: </strong>Children with myopia have a higher OSDI and higher prevalence of dry eye than children without myopia. After adjusting for age, the OSDI was associated with more negative spherical power and the presence of myopia.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2221-2228"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Repeat Deep Anterior Lamellar Keratoplasty in Keratoconus: Case Series.","authors":"Omar Kirat, Rafah Fairaq, Mohammed AlMutlak, Raneem S AlQahtani, Ghadah A AlHussein, Sara AlHilali","doi":"10.2147/OPTH.S528658","DOIUrl":"10.2147/OPTH.S528658","url":null,"abstract":"<p><strong>Purpose: </strong>To report the incidence, indications, and clinical outcomes of repeat deep anterior lamellar keratoplasty (DALK) in keratoconus patients.</p><p><strong>Methods: </strong>Case series.</p><p><strong>Results: </strong>This retrospective study included all repeat DALK procedures for keratoconus performed at King Khaled Eye Specialist Hospital (KKESH) between 2016 and 2024. Patient demographics, surgical techniques, complications, and outcomes were analyzed. Among 2136 primary DALK procedures, only 0.66% (14 eyes) required repeat keratoplasty. The mean age at the time of repeat DALK was 32 and the mean follow-up duration was 30 months. Indications included lipid keratopathy (28.6%), persistent epithelial defect with severe immune reaction (14.3%), high irregular astigmatism (14.3%), and stromal scarring (7.1%). Graft exchange alone was sufficient in most cases (64%), while larger trephination and further dissection (22%) were performed for stromal scars or host rim ectasia. Postoperative complications (43%) included loose sutures (36%), elevated intraocular pressure (7%), and cataract formation (7%). The overall graft survival rate was 93%, with one failure due to poor compliance with postoperative steroids and follow-ups. Visual recovery was favorable, with 57% achieving 20/40 or better.</p><p><strong>Conclusion: </strong>Repeat DALK is a safe and effective alternative to penetrating keratoplasty (PK) for failed primary DALK, offering high graft survival and favorable visual outcomes while minimizing immune-related complications. Postoperative adherence and timely steroid management are critical for optimizing success. Further studies comparing repeat DALK and repeat PK are needed to assess long-term endothelial health and visual stability.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2203-2209"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Apolipoprotein B and B/A1 Ratio as Early Negative Biomarkers for OCT- and OCTA-Detected Retinal Changes in Diabetic Macular Edema.","authors":"Soefiandi Soedarman, Madarina Julia, Tjahjono Darminto Gondhowiardjo, King Hans Kurnia, Alberthus Donni Budi Prasetya, Ichsan Fauzi Triyoga, Muhammad Bayu Sasongko","doi":"10.2147/OPTH.S527436","DOIUrl":"10.2147/OPTH.S527436","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the relationships between serum apolipoprotein A1 (ApoA1) and B (ApoB) levels and the ApoB/A1 ratio with structural and vascular changes in the retinas of patients with diabetic macular edema (DME), as assessed through optical coherence tomography (OCT) and OCT angiography (OCTA).</p><p><strong>Methods: </strong>62 eyes from 38 treatment-naive diabetic retinopathy patients were assessed. Baseline and 6-month evaluations included clinical exams, fundus photography, blood tests for cholesterol, ApoA1, and ApoB, as well as imaging with OCT and OCTA. Associations between apolipoproteins and changes in central retinal thickness (CRT), foveal avascular zone (FAZ), and vessel/perfusion density were analyzed.</p><p><strong>Results: </strong>In DME patients, elevated ApoB levels (>122.5 mg/dL) were significantly linked with increased CRT, FAZ expansion, and reduced perfusion density at the 6-month follow-up (p = 0.026, 0.046, and 0.025). Higher ApoB/A1 ratio (>0.85) was significantly associated with decreased perfusion density (p = 0.011).</p><p><strong>Conclusion: </strong>Elevated ApoB levels and ApoB/A1 ratio were linked with reduced perfusion and vessel density, increased CRT, and FAZ expansion, highlighting their potential as negative biomarkers for OCT-detected retinomacular changes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2165-2178"},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}