Clinical ophthalmology (Auckland, N.Z.)最新文献

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Short-Term Outcomes Using a Novel Femtosecond Laser-Assisted Keratotomy Nomogram to Manage Corneal Astigmatism During Phacoemulsification. 使用新型飞秒激光辅助角膜切开术治疗超声乳化手术期间角膜散光的短期效果。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S500884
Nguyen Truong, Brett Ernst, Gautam Mishra, Catherine Seeger, Ashley Sun, Amy Longenecker, Erik Lehman, Seth M Pantanelli
{"title":"Short-Term Outcomes Using a Novel Femtosecond Laser-Assisted Keratotomy Nomogram to Manage Corneal Astigmatism During Phacoemulsification.","authors":"Nguyen Truong, Brett Ernst, Gautam Mishra, Catherine Seeger, Ashley Sun, Amy Longenecker, Erik Lehman, Seth M Pantanelli","doi":"10.2147/OPTH.S500884","DOIUrl":"10.2147/OPTH.S500884","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of a femtosecond laser assisted astigmatic keratotomy (AK) nomogram (FemtoAK.com) for correction of astigmatism during cataract surgery.</p><p><strong>Patients and methods: </strong>Consecutive patients underwent cataract extraction with AKs and insertion of a non-toric intraocular lens. Eyes with greater than 0.5 D of against-the-rule (ATR) or 1.0 D of with-the-rule (WTR) or oblique (OBL) astigmatism were treated in accordance with the nomogram. Optical biometry and manifest refraction were checked pre- and one-month post-operatively. Outcome measures included correction index (CI), index of success (IOS), and proportion of eyes with less than 0.5 and 1.0 D of astigmatism.</p><p><strong>Results: </strong>Ninety-five eyes from 69 patients were included, of which 41 had ATR, 35 had WTR, and 19 had OBL astigmatism. Corneal CI (ATR = 0.86, WTR = 0.27) indicated a small and large under-correction of ATR and WTR astigmatism, respectively, while refractive CI revealed a near-ideal correction of WTR (ATR = 0.87, WTR = 1.02). The proportion of eyes with less than 0.5 and 1.0 D of refractive astigmatism increased from 28% and 54% pre-operatively to 56% and 92% post-operatively, respectively.</p><p><strong>Conclusion: </strong>The FemtoAK nomogram is effective at reducing corneal astigmatism at the time of cataract surgery. Astigmatic correction was more precise when evaluated by refractive rather than corneal measures.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"721-731"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Swept-Source Anterior Segment Ocular Coherence Tomography and Gonioscopy in Detecting Anterior Chamber Angle Closure. 扫源前段眼相干断层扫描与角镜检查前房闭角的比较。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S498949
Panhathai Yaisiri, Natthanose Panarojwongse, Isaraporn Treesit, Raveewan Choontanom, Ornwasee Jatuthong, Wallop Iemsomboon, Panrapee Funarunart
{"title":"Comparison of Swept-Source Anterior Segment Ocular Coherence Tomography and Gonioscopy in Detecting Anterior Chamber Angle Closure.","authors":"Panhathai Yaisiri, Natthanose Panarojwongse, Isaraporn Treesit, Raveewan Choontanom, Ornwasee Jatuthong, Wallop Iemsomboon, Panrapee Funarunart","doi":"10.2147/OPTH.S498949","DOIUrl":"10.2147/OPTH.S498949","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the diagnostic accuracy of swept-source anterior segment optical coherence tomography (AS-OCT) with gonioscopy in detecting angle closure among narrow-angle suspected eyes.</p><p><strong>Patients and methods: </strong>A total of 125 eyes determined narrow anterior chamber angles suspected by Van Herick's technique grade 0, 1, or 2 were recruited. AS-OCT was undergone before any contact procedure. Intraocular pressure (IOP) measurements using applanation tonometry and gonioscopy were performed, respectively. AS-OCT images were blindly interpreted by 3 glaucoma specialists, involving both qualitative assessments at 0, 90, 180, and 270 degrees and quantitative analysis using iris-trabecular contact (ITC) index. The sensitivity and specificity of AS-OCT, compared with gonioscopy-the gold standard for identifying anterior chamber angle closure-were calculated.</p><p><strong>Results: </strong>The mean age was 61±12.9 years, and females constituted 67.6%. Eyes classified by Van Herick's technique as grade 0, 1 and 2 were 16%, 58.40%, and 25.60%, respectively. Closed-angle identified by gonioscopy and AS-OCT were 100 eyes (80%) and 102 eyes (81.60%), respectively. The sensitivity and specificity of AS-OCT in detecting angle-closure were 92.16% (95% CI, 87.44-96.87) and 73.91% (66.22-81.61), respectively. For angle-closure identified by ITC index ≥ 55%, sensitivity was 86.36% (77.53-95.20) and specificity was 92.86 (86.23-99.49). The inter-observer agreement of gonioscopy was moderate (Kappa = 0.55), while the intra-observer and inter-observer agreement of AS-OCT was substantial (Kappa = 0.71-0.80 and Kappa = 0.69, respectively).</p><p><strong>Conclusion: </strong>AS-OCT enables a contactless qualitative and quantitative assessment of angle-closure in narrow-angle suspected eyes, demonstrating high sensitivity, acceptable specificity, and good inter-observer and intra-observer reliability.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"699-711"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Evaluation of Central and Peripheral Lens Densities Post Implantation of Implantable Collamer Lens V4c. V4c人工晶体植入后中央和周围晶状体密度的长期评价。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S500512
I-Chun Lin, Yinjie Jiang, Mingrui Cheng, Boliang Li, Yadi Lei, Guanghan Xu, Mingwei Li, Zhiwei Mao, Ning Rui, Xun Chen, Xiaoying Wang
{"title":"Long-Term Evaluation of Central and Peripheral Lens Densities Post Implantation of Implantable Collamer Lens V4c.","authors":"I-Chun Lin, Yinjie Jiang, Mingrui Cheng, Boliang Li, Yadi Lei, Guanghan Xu, Mingwei Li, Zhiwei Mao, Ning Rui, Xun Chen, Xiaoying Wang","doi":"10.2147/OPTH.S500512","DOIUrl":"10.2147/OPTH.S500512","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the impact of long-term ICL implantation on lens density, focusing on the relationship between the anterior subcapsule, anterior lens density, and implantable collamer lenses (ICL) position after ICL V4c implantation.</p><p><strong>Methods: </strong>This retrospective study included 145 eyes with ICL V4c implantation and average follow-up of 4.2 years (range: 3-8 years). The control group comprised 65 myopic eyes without surgery. All participants underwent comprehensive ophthalmologic examinations, and lens density were measured using quantitative Scheimpflug images.</p><p><strong>Results: </strong>The central anterior subcapsular densities were 8.62 ± 1.39% preoperatively, 8.99 ± 1.31% at 3 months, and 9.29 ± 0.95% at the last follow-up post ICL implantation (p < 0.001). At last follow-up, the anterior subcapsular densities were 9.29 ± 0.95% in the central region, 8.92 ± 0.79% in the long axis of peripheral region, and 8.62 ± 0.76% in the short axis of peripheral region (p < 0.001). The densities were lower in the non-surgical group than in the ICL implantation group. One eye (0.69%) was discovered to have anterior subcapsular and nuclear opacification.</p><p><strong>Conclusion: </strong>The density of the anterior subcapsule increased over time after ICL implantation. Preoperative refraction and pupil size were correlated with changes in anterior subcapsule density. The central anterior subcapsule density was higher than that at the periphery, and the peripheral density of the long axis was higher than that of the short axis.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"733-745"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Rhegmatogenous Retinal Detachment Repair by Pars Plana Vitrectomy With and Without Scleral Buckling: A Propensity Score Analysis [Response to Letter]. 有或没有巩膜屈曲的玻璃体切割修复原发性孔源性视网膜脱离:倾向评分分析。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S521481
Pongthep Rajsirisongsri, Direk Patikulsila, Phichayut Phinyo, Paradee Kunavisarut, Voraporn Chaikitmongkol, Onnisa Nanegrungsunk, Atitaya Apivatthakakul, Sutheerada Seetasut, Yaowaret Tantivit, Napatsorn Krisanuruks, Apisara Sangkaew, Nawat Watanachai, Janejit Choovuthayakorn
{"title":"Primary Rhegmatogenous Retinal Detachment Repair by Pars Plana Vitrectomy With and Without Scleral Buckling: A Propensity Score Analysis [Response to Letter].","authors":"Pongthep Rajsirisongsri, Direk Patikulsila, Phichayut Phinyo, Paradee Kunavisarut, Voraporn Chaikitmongkol, Onnisa Nanegrungsunk, Atitaya Apivatthakakul, Sutheerada Seetasut, Yaowaret Tantivit, Napatsorn Krisanuruks, Apisara Sangkaew, Nawat Watanachai, Janejit Choovuthayakorn","doi":"10.2147/OPTH.S521481","DOIUrl":"10.2147/OPTH.S521481","url":null,"abstract":"","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"691-692"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Corneal Arcus on the Sealing of Clear Corneal Incisions in Cataract Surgery. 白内障手术中角膜弧度对角膜切口闭合的影响。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S511669
Mizuho Yoshida, Kouhei Hashizume, Toshiyasu Imaizumi, Tetsuya Hashiura, Daijiro Kurosaka
{"title":"Impact of Corneal Arcus on the Sealing of Clear Corneal Incisions in Cataract Surgery.","authors":"Mizuho Yoshida, Kouhei Hashizume, Toshiyasu Imaizumi, Tetsuya Hashiura, Daijiro Kurosaka","doi":"10.2147/OPTH.S511669","DOIUrl":"https://doi.org/10.2147/OPTH.S511669","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether the corneal arcus affects sealing of the clear corneal incision (CCI) in cataract surgery.</p><p><strong>Patients and methods: </strong>This study was a retrospective cohort study. The patients were divided into two groups based on whether stromal hydration was required to close the CCI. The corneal arcus was classified according to its degree as none, partial (if corneal arcus < 180 degrees), and circumferential (if corneal arcus ≥ 180 degrees). Multiple logistic regression was conducted to identify independent variables such as age at cataract surgery, sex, laterality, surgical time, and degree of corneal arcus associated with CCI sealing.</p><p><strong>Results: </strong>Among a total of 83 eyes of 83 patients, a partial corneal arcus was found in 34 eyes (41.0%) and a circumferential arcus in 33 eyes (39.8%). Multiple logistic regression analysis revealed that the need for stromal hydration in wound sealing increased with surgical time (OR = 1.7313, 95% CI = 1.1500-2.6063, p = 0.0085) and decreased with severity of corneal arcus (partial, OR = 0.2901, 95% CI = 0.0451-1.8665, p=0.1926; circumferential, OR = 0.0590, 95% CI = 0.0074-0.4722, p = 0.0085); age was not associated (OR = 0.9790, 95% CI = 0.9121-1.0507, p = 0.5555).</p><p><strong>Conclusion: </strong>Eyes with corneal arcus required less stromal hydration. This finding suggests that corneal arcus may increase CCI sealing in cataract surgery.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"693-698"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Emergency Department Intraocular Pressure and Visual Acuity Assessment as a Screening Exam. 评估急诊科眼压和视力评估作为筛查检查。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S511327
Karine D Bojikian, Thellea K Leveque, Anna McEvoy, Blake Hopkin, Nadia Popovici, Hyrum Hopkin, Grant Howell, Mary E Kim, Jennifer T Yu, Andrew Chen, Leona Ding, Parisa Taravati, Kristina Tarczy-Hornoch, Shu Feng
{"title":"Assessment of Emergency Department Intraocular Pressure and Visual Acuity Assessment as a Screening Exam.","authors":"Karine D Bojikian, Thellea K Leveque, Anna McEvoy, Blake Hopkin, Nadia Popovici, Hyrum Hopkin, Grant Howell, Mary E Kim, Jennifer T Yu, Andrew Chen, Leona Ding, Parisa Taravati, Kristina Tarczy-Hornoch, Shu Feng","doi":"10.2147/OPTH.S511327","DOIUrl":"https://doi.org/10.2147/OPTH.S511327","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the utility of Emergency Department (ED) assessment of intraocular pressure (IOP) and visual acuity (VA) measurements as a screening tool for abnormal IOP and VA on ophthalmology exams.</p><p><strong>Patients and methods: </strong>This retrospective cross-sectional study reviewed eye-related ED visits between February 1, 2022, and January 31, 2023, at Harborview and University of Washington Medical Centers (Seattle, WA) with same-day ophthalmology consultation. Electronic medical records were reviewed for right eye and left eye IOP and VA obtained by ED and ophthalmology services. The ED exam as a screening tool for abnormal IOP (>25 mmHg) and visual acuity (<20/40) on ophthalmology exam in either eye was evaluated using receiver operating curves (ROC). A calculator user interface was created to report sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with a range of user inputs for both the thresholds applied to ED measurements and the targets for detection for Ophthalmology IOP and VA.</p><p><strong>Results: </strong>Of 1463 visits, IOP and VA were recorded in at least 1 eye by the ED in 627 (42.8%) and 821 (56.1%) patients, respectively. The area under the curve (AUC) for the receiver operating curves for ED screening was 0.846 for detecting an abnormal IOP and 0.863 for detecting an abnormal VA. The sensitivity of a value >25 mmHg on ED IOP testing was 0.78 (95% CI 0.69-0.87), and the specificity was 0.84 (95% CI 0.80-0.87). The sensitivity of a VA value logMAR >0.3 (worse than 20/40) on ED testing was 0.88 (95% CI 0.85-0.91), and the specificity was 0.59 (95% CI 0.54-0.65).</p><p><strong>Conclusion: </strong>ED acquired measurements of IOP and VA are useful to screen for abnormalities in IOP and VA on the ophthalmology exam. However, IOP and VA are infrequently obtained by the ED prior to ophthalmic consultation.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"683-690"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Direct Cyclopexy for Traumatic Cyclodialysis Cleft: A Retrospective Clinical Study. 直接睫状体固定术治疗外伤性睫状体透析裂的回顾性临床研究。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S484518
Xiaoqiang Wang, Zhixin Jiang, Xiubin Ma
{"title":"Effect of Direct Cyclopexy for Traumatic Cyclodialysis Cleft: A Retrospective Clinical Study.","authors":"Xiaoqiang Wang, Zhixin Jiang, Xiubin Ma","doi":"10.2147/OPTH.S484518","DOIUrl":"https://doi.org/10.2147/OPTH.S484518","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical effects of direct cyclopexy in the treatment of traumatic cyclodialysis cleft.</p><p><strong>Methods: </strong>This is a retrospective case study. Patients with traumatic cyclodialysis cleft, who were treated with direct cyclopexy and had complete medical records at Tianjin Eye Hospital between February 2021 and August 2022 were selected. The detailed characteristics of the 23 patients were analyzed. Preoperative and postoperative visual acuity, intraocular pressure (IOP), and the extent of ciliary detachment were recorded. All patients were followed up for six months.</p><p><strong>Results: </strong>19 of the 23 patients who underwent single direct cyclopexy, the other 4 patients with severe posterior segment damage underwent direct cyclopexy combined with vitrectomy, suprachoroidal drainage, etc. After surgery, 22 of the 23 patients successfully reset the ciliary body, including four patients who underwent combined operations, which showed a statistically significant difference (P < 0.01). The mean preoperative IOP was 6.48 ± 1.62 mmHg and it has a different degree of rebound in 21 cases reaching 13.29 ± 2.11 mmHg on 6 months after operation, including 6 cases of transient high intraocular pressure (> 21 mmHg) (P < 0.01). Best corrected visual acuity was increased from preoperatively 0.60 ± 0.21 logMAR to 0.38 ± 0.26 log MAR postoperatively, in which the vision > 0.3 logMAR reached 65.2% (P < 0.01).</p><p><strong>Conclusion: </strong>Direct cyclopexy with or without vitrectomy is an effective method for treating traumatic ciliary body detachment.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"673-681"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystoid Macular Edema Following Rhegmatogenous Retinal Detachment Repair Surgery: Incidence, Pathogenesis, Risk Factors and Treatment. 孔源性视网膜脱离修复手术后黄斑水肿的发生率、发病机制、危险因素和治疗。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S489859
Enrico Bernardi, Neil Shah, Lorenzo Ferro Desideri, Jelena Potic, Janice Roth, Rodrigo Anguita
{"title":"Cystoid Macular Edema Following Rhegmatogenous Retinal Detachment Repair Surgery: Incidence, Pathogenesis, Risk Factors and Treatment.","authors":"Enrico Bernardi, Neil Shah, Lorenzo Ferro Desideri, Jelena Potic, Janice Roth, Rodrigo Anguita","doi":"10.2147/OPTH.S489859","DOIUrl":"10.2147/OPTH.S489859","url":null,"abstract":"<p><strong>Purpose: </strong>To review the incidence, risk factors, and treatments for cystoid macular edema (CME) following rhegmatogenous retinal detachment (RRD) repair surgery.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases. Relevant studies published within the last 20 years were selected and reviewed.</p><p><strong>Results: </strong>The incidence of CME following RRD repair ranges from 6% to 36%, with higher rates associated with silicone oil tamponade. Key risk factors include recurrent RRD, pre-existing proliferative vitreoretinopathy, older age, and post-RRD cataract surgery. Treatment options primarily focus on anti-inflammatory approaches, with topical NSAIDs and corticosteroids as first-line treatments. For persistent cases, intravitreal corticosteroid injections, particularly dexamethasone implants, have shown potential.</p><p><strong>Conclusion: </strong>CME remains a significant complication following RRD repair, impacting visual recovery. While various treatment options exist, management of persistent CME remains challenging. Better understanding of the underlying mechanisms of CME is required to develop more effective treatment strategies, particularly for cases resistant to current therapies.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"629-639"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influential Factors and Outcome of High-Risk Keratoplasty in a Tertiary Referral Corneal Center: A Retrospective Study. 三级转诊角膜中心高危角膜移植的影响因素和结果:一项回顾性研究。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S502563
Julia Aschauer, Michal Klimek, Ruth Donner, Irene Steiner, Jan Lammer, Gerald Schmidinger
{"title":"Influential Factors and Outcome of High-Risk Keratoplasty in a Tertiary Referral Corneal Center: A Retrospective Study.","authors":"Julia Aschauer, Michal Klimek, Ruth Donner, Irene Steiner, Jan Lammer, Gerald Schmidinger","doi":"10.2147/OPTH.S502563","DOIUrl":"10.2147/OPTH.S502563","url":null,"abstract":"<p><strong>Purpose: </strong>Corneal allograft survival is dramatically decreased in high-risk (HR) host beds. The purpose of this study was to investigate the outcome of HR keratoplasty (KP) in a single-center tertiary referral clinic and to determine risk factors for graft failure.</p><p><strong>Methods: </strong>This retrospective study included adults referred for HR penetrating KP between 2014 and 2022. HR criteria were history of re-KP, stromal neovascularization in ≥2 quadrants, and signs of significant inflammation/manifest perforation at the time of surgery. The primary endpoint was graft failure within the first postoperative year. Donor endothelial cell count, donor age, stromal neovascularization, and manifest perforation/acute inflammation at surgery were independent variables in the univariate/multivariable logistic regression.</p><p><strong>Results: </strong>Graft survival 1 year after surgery was 56.2% (CI: 45.7, 66.4), 68.3% (CI: 59.3, 76.4), and 70.2% (CI: 56.6, 81.6) after the first, second, and third KP, respectively. The presence of perforation/acute inflammation at baseline was found to be an independent factor statistically significantly associated with graft failure. Graft failure occurred in 190 (51%) of 375 KPs in 257 patients during overall observation. The median time (95% CI) from KP until graft failure was 559 (392, 994) days for the 1<sup>st</sup> KP, 1052 (833, 1375) days for the 2<sup>nd</sup> KP and 1089 (689, inf) for the 3<sup>rd</sup> KP. The most frequent cause was immune rejection (n=55, 29%), whereas in a majority (n=66, 35%) the reason remained undefined. The median time (95% CI) until neovascularization (re-) formation after KP was 739 days (550, inf) and 1566 (1055, inf) days for the 1st and the 2nd KP.</p><p><strong>Conclusion: </strong>Acute inflammation/perforation at the time of surgery were the major risk factors for graft failure in HR KP. Reduced survival rates for HR KPs were confirmed in this study, which highlights the need for further developments in the treatment of these patients.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"653-662"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicodemographic Profile of Visual Disability Among Applicants for Disability Certification in South India. 在印度南部申请残疾认证的申请人中视力残疾的临床人口学概况。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S489309
Nivedha Venkataraghavan, Rajesh R Nayak, Teena Mariet Mendonca, Anitha Kiran, Soumya Padenkilmar Devendra, Ajay R Kamath, Gurudutt Kamath, Gladys Rodrigues
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