Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Impact of Mining on the Ocular Surface Health Among Residents of Mining Communities.","authors":"Smruti Rekha Priyadarshini, Sujata Das, Mamatha M Reddy, Srikant Kumar Sahu, Komal Sukhadev Avhad","doi":"10.2147/OPTH.S512119","DOIUrl":"https://doi.org/10.2147/OPTH.S512119","url":null,"abstract":"<p><strong>Purpose: </strong>Despite known associations between air pollution and ocular health, the specific impact of mining dust on ocular surface health remains largely unexplored. This study aims to address this gap by determining the ocular surface characteristics, the prevalence of dry eye disease (DED), tear film inflammatory markers, and their clinical correlation among people residing in mining communities.</p><p><strong>Methods: </strong>This was a prospective one-year study at a primary eye care centre that included 376 participants. The participants were categorized into three sub-groups based on the duration of exposure to mining activities, namely high exposure (A: >8 h), moderate exposure (B: 2-8 h;), and minimal exposure (C: <2 h). The participants underwent thorough clinical examinations, ocular surface disease index (OSDI) scoring, Schirmer's test (without anaesthesia), ocular surface analyser and surface staining. The tear samples were analysed for selected inflammatory markers, such as interleukin-1Ra, interleukin-6, interleukin-8, tumour necrosis factor-alpha (TNF-α), and matrix metalloproteinase 9 using multiplex enzyme-linked immunosorbent assay. Bivariate and multivariate regression models with odds ratios were used for the statistical analyses.</p><p><strong>Results: </strong>The prevalence of dry eyes was 15.4%. The OSDI and Schirmer's test scores were poor in group C and A as compared to group B. The risk of DED (p<0.05) increased with advancing age and elevated blood pressure and correlates with surface staining. No significant association could be established between the inflammatory markers and dry eyes using cytokine titres.</p><p><strong>Conclusion: </strong>DED is prevalent in mining communities. Safety gear, periodic eye examinations, and appropriate treatment are recommended.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1401-1410"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRESERFLO Microshunt™ versus Non-Penetrating Deep Sclerectomy for Glaucoma Management, One-Year Results.","authors":"Bruna Cunha, Pedro Gil, Edgar Lopes, Maria Elisa-Luís, Maria Reina, Teresa Gomes, Joana Cardigos","doi":"10.2147/OPTH.S514126","DOIUrl":"https://doi.org/10.2147/OPTH.S514126","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the short-term efficacy and safety of the PRESERFLO™ MicroShunt (PF) versus Non-Penetrating Deep Sclerectomy (NPDS) with Esnoper^®.</p><p><strong>Methods: </strong>Retrospective comparative cohort study at a tertiary hospital including 79 eyes from 79 patients submitted to surgery (32 PF implantation, Group 1 and 47 NPDS, Group 2) between January 2022 and August 2023, with one year follow-up. Outcome measures included intraocular pressure (IOP), complications, surgical duration, postoperative major and minor interventions. Surgical failure was defined as IOP>21 mmHg or <20% reduction from baseline, IOP<5 mmHg, major postoperative intervention, or loss of light perception. Conversely, success was defined as the absence of these failure criteria: complete success without glaucoma medications, and qualified success with.</p><p><strong>Results: </strong>Baseline characteristics, including age, sex, IOP, number of IOP-lowering medications, and visual field defects, were comparable between groups (p>0.05). After one year, IOP decreased significantly in both groups (PF: 20.13±6.20 to 15.00±3.15 mmHg; NPDS: 19.57±5.73 to 13.30±3.59 mmHg, both p<0.001). Complete success rates were 28.1% for PF and 40.4% for NPDS (p=0.189), while surgical failure was significantly higher in the PF group (65.6% vs 38.3%, p=0.015). Major reinterventions were more frequent with PF (10 vs 3, p=0.005), partly due to encapsulated blebs, while NPDS required more minor interventions (2 vs 17, p=0.002). Complication rates were similar (31.3% vs 14.9%, p=0.073), but surgical duration was shorter in the PF group (60.03±17.95 min vs 69.91±15.23 min, p=0.008).</p><p><strong>Conclusion: </strong>PF and NPDS share comparable safety profiles. Although PF surgery is faster, it is associated with a higher rate of major postoperative interventions and failure. NPDS, while requiring more minor interventions, such as goniopuncture and needling, rarely demands major re-interventions. NPDS is known for its meticulous and technically challenging technique, but once mastered, it can result in fewer invasive re-interventions and improved efficacy.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1377-1386"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic and Functional Outcomes of Lamellar Macular Hole and Epiretinal Membrane Foveoschisis Surgery: Predictive Factors and Associated Complications - A Retrospective Interventional Study.","authors":"Yosra Er-Reguyeg, Sihame Doukkali, Mélanie Hébert, Eunice Linh You, Serge Bourgault, Mathieu Caissie, Éric Tourville, Ali Dirani","doi":"10.2147/OPTH.S499493","DOIUrl":"https://doi.org/10.2147/OPTH.S499493","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the anatomic and functional outcomes of lamellar macular hole (LMH) and epiretinal membrane foveoschisis (ERMF) surgery.</p><p><strong>Patients and methods: </strong>This is a retrospective interventional cohort study of ninety patients with unilateral idiopathic LMH or ERMF who underwent pars plana vitrectomy (PPV) with membrane peeling between 2014 and 2021. We evaluated the anatomic and functional success of PPV with membrane peeling for treating LMH and ERMF, compared surgical outcomes between the two entities, and identified predictive factors for anatomical and functional success. Primary outcomes included final postoperative best-corrected visual acuity (BCVA) and LMH or ERMF closure. Variables associated with final BCVA were assessed using a multiple linear regression model.</p><p><strong>Results: </strong>51 subjects presented with ERMF, while 39 presented with LMH. LMH or ERMF closure occurred in 80 cases. LMH cases had a lower rate of closure (LMH closure rate: 76.9%, vs ERMF closure rate: 98.0%, p=0.002) and were more at risk of developing a postoperative macular hole (p=0.008). A significant difference was observed between median [Q1, Q3] preoperative BCVA (0.42 [0.26, 0.61] logMAR) and final BCVA (0.31 [0.14, 0.48] logMAR, p=0.024). BCVA varied from 0.52 [0.40, 0.74] logMAR preoperatively to 0.36 [0.30, 0.66] logMAR postoperatively in the LMH subgroup (p=0.060), and from 0.32 [0.20, 0.54] logMAR preoperatively to 0.22 [0.10, 0.40] logMAR postoperatively in the ERMF subgroup (p=0.146). LMH without epiretinal proliferation (β=0.194, p=0.040) was associated with worse final BCVA in multivariate analysis.</p><p><strong>Conclusion: </strong>Results support the effectiveness of PPV as a treatment for LMH. LMHs had worse anatomic outcomes than ERMFs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1365-1376"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Rotational Stability Over Time Between Four Monofocal Toric Intraocular Lenses.","authors":"Peter Hoffmann, Richard Potvin, Robert D Anello, Fritz Hengerer, Gerd Auffarth, Yves Guldenfels, Eckart Bertelmann, Ramon Ruiz Mesa, Isaak Fischinger, Sandra Krawczyk, Berthold Seitz, David Antolin-Garcia, Stefanie Schmickler, Louis Hoffart, Thomas Kohnen, Alvin S Relucio","doi":"10.2147/OPTH.S522728","DOIUrl":"https://doi.org/10.2147/OPTH.S522728","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the rotational stability of four different monofocal toric intraocular lenses (IOLs) from surgery to 4-6 months postoperative.</p><p><strong>Methods: </strong>This was a subset of data from a prospective multi-center randomized clinical study. High resolution retro-illuminated images of eyes implanted with four different toric IOLs were obtained immediately after surgery, and at 1 day, 1 week, 1 month and 4-6 months after surgery. Fixed scleral features were identified in the surgical image. An independent reading center evaluated the orientation of the IOL from all images, based on the angle between the toric axis marks and these fixed scleral landmarks. Rotational stability was determined by calculating differences in orientation between visits.</p><p><strong>Results: </strong>Digital images from 299 eyes implanted with one of the four IOLs were available for analysis. Orientation data were successfully determined in about 90% of images. Biometry and IOL orientation were not significantly associated with IOL rotation. The Vivinex lens showed the lowest absolute rotation, with a mean value less than 1.5 degrees at all time intervals measured, with a maximum standard deviation of 1.4 degrees. The AcrySof lens was next lowest, with an absolute rotation below two degrees for all intervals. Mean absolute rotation for the Tecnis lens was significantly higher than for the other IOLs (>2 degrees for all intervals). For the AcrySof and Vivinex lenses, there were no reported rotations >10 degrees for any interval; 97% or more of results were <5 degrees, compared to 93% for the AT Torbi lens and 90% for the Tecnis lens. Only 6 lenses (4 Tecnis: 8.3%, 2 AT Torbi: 4.3%) had a rotation > 10 degrees at any time point.</p><p><strong>Conclusion: </strong>Rotational stability appeared excellent for the Vivinex and AcrySof toric IOLs, with slightly more variable performance evident with the AT Torbi and Tecnis IOLs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1345-1355"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Occlusion Break Surge Volume in Five Different Phacoemulsification Systems.","authors":"Satish Yalamanchili, Ali Aboughaida, Omid S Rohani, David William Dyk","doi":"10.2147/OPTH.S516801","DOIUrl":"https://doi.org/10.2147/OPTH.S516801","url":null,"abstract":"<p><strong>Purpose: </strong>To compare surge volume after occlusion breaks in five phacoemulsification systems.</p><p><strong>Methods: </strong>A mechanical spring-eye model was used to evaluate the Legion™ Vision System with the Single Use Fluidics Management System (FMS) (LEG), Infiniti™ Vision System with Intrepid™ Plus FMS (INF), Whitestar Signature Pro^® with the OPO73 pack (WSP), Compact Intuitiv^® with the OPO80 pack (CIS), and Stellaris PC^® with the StableChamber cassette (SPC). Transient occlusion break surge volume responses were assessed across a full range of system settings (IOP: 30 to 80 mmHg; vacuum limit: 300 to 650 mmHg; aspiration rate: 20 or 40 cc/min. Oscilloscope waveforms covered stable flow before occlusion, full occlusion, occlusion break, and full recovery to stable flow. Raw oscilloscope data were converted to volumetric and pressure measurements. Fitted average surge traces were generated for each test condition and used to develop an interpolation algorithm to predict transient occlusion break surge events.</p><p><strong>Results: </strong>The minimum surge volume for all systems occurred at the highest IOP (80 mmHg) and the lowest tested vacuum limit (300 mmHg). Overall, the surge volume increased with increasing vacuum limit and decreasing IOP on the LEG, INF CIS, WSP, and SPC systems. The occlusion break surge volumes (µL [standard deviation]) at 60 mmHg IOP and vacuum limit of 500 mmHg were 70.4 [8.1] for LEG; 87.4 [9.7] for INF; 85.8 [7.2] for CIS; 69.5 [5.0] for WSP; and 151.7 [20.2]) for SPC. A Games-Howell post-hoc test showed significant differences between three groups: A) LEG/WSP, B) CIS/INF, and C) SPC.</p><p><strong>Conclusion: </strong>The Legion system demonstrated comparable or lower predicted surge volume after occlusion breaks compared to the other phacoemulsification systems evaluated. Reductions in occlusion break surge volumes are expected to decrease the rate of complications and lead to improved outcomes in the clinical cataract surgery setting.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1357-1364"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Hypertension Following Open Globe Injury in Patients Undergoing Pars Plana Vitrectomy.","authors":"Sam Karimaghaei, Hytham Al-Hindi, Muhammad Z Chauhan, Abdelrahman M Elhusseiny, Carina T Sanvicente, Sami H Uwaydat","doi":"10.2147/OPTH.S499595","DOIUrl":"https://doi.org/10.2147/OPTH.S499595","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors and rates of post-traumatic ocular hypertension (OHT) in patients undergoing pars plana vitrectomy (PPV) for open-globe injuries.</p><p><strong>Patients and methods: </strong>Retrospective chart study including 98 eyes from 98 patients between 2008 and 2022 with open globe injuries who were hospitalized at a single academic institution and received first repair or exploration followed by PPV. Variables recorded included timing to the first PPV, best-corrected final visual acuity (VA) at the last follow-up, incidence of enucleation, type of injury, use of intravitreal antibiotics, number of eye surgeries, use of oral steroids, acetazolamide use, topical steroid use, lens status, silicone oil placement, and zone of injury (1-3). The ocular trauma score (OTS) was calculated using the variables globe rupture, development of endophthalmitis, initial VA, globe perforation, retinal detachment, and the presence of a relative afferent pupillary defect (RAPD). The primary endpoint was elevated intraocular pressure (IOP) sustained for more than six weeks following PPV. We performed a logistic regression to determine the factors that predicted the development of OHT post-PPV.</p><p><strong>Results: </strong>Of 98 eyes included in the primary analysis, a total of 34 (34.69%) were diagnosed with sustained ocular hypertension (OHT) and 64 (65.31%) remained normotensive. The mean final IOP in the OHT group was 16.96 mmHg and 12.11 mmHg in the normotensive group (P < 0.01). Sex, age, OTS, injury type, zone of injury, preoperative IOP, and final VA were comparable between the OHT and normotensive groups. When adjusting for OTS, the use of silicone oil significantly predicted the development of ocular hypertension (odds ratio [95% CI], 5.63 [1.57-20.11]).</p><p><strong>Conclusion: </strong>The incidence of ocular hypertension in our cohort was slightly higher than previously reported at 34.69%. PPV has been independently associated with elevated IOP post-operatively, but the need for PPV surgery can indicate more severe trauma leading to higher rates of increased IOP. Patients who had silicone oil utilized in their PPV had an approximately 5.63-fold increased odds of developing OHT, suggesting that silicone oil use may be a potent predictor of post-PPV OHT.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1339-1344"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Outcomes of Combined Phacoemulsification and STREAMLINE^® Canaloplasty: Interim Analysis of a Longitudinal Single-Center Retrospective Study.","authors":"Joseph Stanke, Don Nguyen","doi":"10.2147/OPTH.S508611","DOIUrl":"https://doi.org/10.2147/OPTH.S508611","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical outcomes of a novel ab interno minimally invasive procedure with the STREAMLINE^® Surgical System for creation of incisional goniotomies and canaloplasty in eyes with primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>In a retrospective analysis of all consecutive cases performed and followed for up to 12 months, 51 eyes of 51 subjects with mild, moderate, and severe primary open-angle glaucoma (POAG) underwent canaloplasty and incisional goniotomy following phacoemulsification cataract extraction. The procedure was performed according to the manufacturer's instructions for use. However, in contrast to other studies where the technique involved solely incisional goniotomy during viscoelastic delivery, in this study, a 1-2 clock hour goniotomy was created with the cannula after 3-6 injections of viscoelastic into Schlemm's canal. Outcomes in this interim analysis included mean reduction in IOP and medications through month 12, as well as the proportion of eyes achieving IOP reduction ≥20% from baseline.</p><p><strong>Results: </strong>Mean preoperative IOP was 16.9 mmHg using a mean of 1.2 medications (n = 51). At 30 days post-op, mean IOP was 15.3 mmHg using a mean of 0.2 medications; 21.6% (11/51) had IOP reduction ≥20% from baseline; 90.2% (46/51) were medication-free. At 6 months post-op, mean IOP was 15.6 mmHg using a mean of 0.2 medications; 21.6% (11/51) had IOP reduction ≥20% from baseline; 90.2% (46/51) were medication-free. At 12 months post-op, mean IOP was 17.0 mmHg using a mean of 0.2 medications, 37.3% (19/51) had IOP reduction ≥20% from baseline; 88.2% (45/51) were medication-free. No adverse events were reported. No secondary surgical interventions were required in any patient.</p><p><strong>Conclusion: </strong>Canaloplasty and incisional goniotomy combined with phacoemulsification safely and effectively reduced dependence on IOP-lowering medications while adequately managing IOP in eyes with primary open-angle glaucoma through 12 months of follow-up.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1331-1337"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proactive Post-Injection Monitoring in Brolucizumab Therapy: A Study on Intraocular Inflammation and Treatment Outcomes.","authors":"Manoj Soman, Apoorva Jadhav, Abhaya Balakrishnan, Jay U Sheth, Unnikrishnan Nair","doi":"10.2147/OPTH.S520118","DOIUrl":"https://doi.org/10.2147/OPTH.S520118","url":null,"abstract":"<p><strong>Purpose: </strong>Intravitreal anti-VEGF agents, such as Brolucizumab, play a crucial role in treating neovascular age-related macular degeneration (nAMD) and Polypoidal choroidal vasculopathy (PCV). While Brolucizumab offers advantages like extended duration and fewer injections, concerns about intraocular inflammation (IOI) have emerged. This study evaluates the outcomes of a proactive monitoring protocol for Brolucizumab-treated eyes with resistant nAMD and PCV.</p><p><strong>Patients and methods: </strong>A single-center retrospective study analyzed patients treated with Brolucizumab for resistant nAMD and PCV. Data on demographics, visual outcomes and IOI incidence, with the latter being confirmed by clinicians. Additional data on management strategies and follow-up adherence were also analyzed. Proactive monitoring included telephonic follow-up on day one and mandatory clinic visits on days 15 and 30. Retreatment followed a pro-re-nata (PRN) approach based on fluid persistence or visual acuity loss.</p><p><strong>Results: </strong>Between February 2022 and September 2024, 311 Brolucizumab injections were administered to 144 eyes of 121 patients, with a mean follow-up of 8.6 months. IOI occurred in 7 eyes (4.9%), with a mean onset of 32.1 days. According to the HAWK and HARRIER discomfort grading scale, IOI was categorized as mild in 2 eyes (28.6%), moderate in 3 eyes (42.9%), and severe in 2 eyes (28.6%). Symptoms varied, including blurred vision, floaters, redness, and ocular pain. Inflammation was managed with topical and oral steroids, with resolution in 6 weeks for vasculitis and 9 weeks for vitritis, and no cases required intravitreal agents or vitrectomy. Visual acuity improved or remained stable for most, except in one case of persistent vitritis.</p><p><strong>Conclusion: </strong>This study highlights the incidence of IOI with Brolucizumab in a real-world setting, emphasizing the importance of proactive monitoring and early intervention. Despite the occurrence of inflammation, visual outcomes were generally favorable, supporting the safety of Brolucizumab when managed carefully.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1313-1321"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Corneal Sensitivity Loss in Patients with and without Dry Eye Disease.","authors":"Matthew Stolz","doi":"10.2147/OPTH.S513005","DOIUrl":"https://doi.org/10.2147/OPTH.S513005","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the prevalence of corneal sensitivity loss in consecutive patients presenting to the clinic as well as in those patients with and without dry eye disease (DED).</p><p><strong>Methods: </strong>Retrospective, single-center study of consecutive patients who presented to the eye clinic and underwent corneal sensitivity testing using a non-contact esthesiometer. Data included demographics, medical history, prior or current treatments, comorbidities, corneal sensitivity measurements, dry eye symptoms (Standard Patient Evaluation of Eye Dryness Questionnaire [SPEED] questionnaire), and corneal staining scores (Oxford scale). The primary outcome was the prevalence of corneal sensitivity loss, defined as ≥8 mbar. Secondary outcome measures included the prevalence of corneal sensitivity loss in eyes with DED (Oxford ≥2 and SPEED ≥5) and without DED (Oxford ≤1 and SPEED <5).</p><p><strong>Results: </strong>A total of 395 eyes of 198 patients were included for analysis. Average age was 67.7 ± 16.0 years, and the majority of patients (60.6%) were female. Corneal sensitivity loss was observed in 9.4% of all eyes, and 12.6% of patients had reduced corneal sensitivity in at least one eye. When assessing eyes with signs of DED (Oxford ≥2), 19.7% (13/66) had corneal sensitivity loss. This prevalence increased to 31.4% (11/35) in eyes with both signs and symptoms of DED. Conversely, the prevalence was 5.5% (12/219) in eyes without DED. Binary logistic regression demonstrated that Oxford staining score was the strongest predictor of reduced corneal sensitivity (OR: 2.0, 95% CI: 1.3-3.0, p=0.001), with other significant factors including history of DED, stroke, and herpes zoster virus.</p><p><strong>Conclusion: </strong>Reduced corneal sensation, a sign of corneal nerve damage and precursor to neurotrophic keratitis, affects nearly 10% of all eyes and 30% of eyes with signs and symptoms of DED. Routine clinical testing of corneal sensation should be implemented, particularly in patients with DED, to ensure early diagnosis and prompt treatment to prevent disease progression.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1323-1330"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Surgical Outcome of Trabeculectomy with Mitomycin C: A Comparison Between Primary and Secondary Glaucoma in Thailand.","authors":"Ployroung Arampinyokul, Kulawan Rojananuangnit","doi":"10.2147/OPTH.S518659","DOIUrl":"https://doi.org/10.2147/OPTH.S518659","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the long-term surgical outcomes of trabeculectomy with mitomycin C (MMC) and identify factors associated with surgical failure in Thai patients with primary and secondary glaucoma.</p><p><strong>Methods: </strong>This retrospective study included 421 eyes from 397 patients with glaucoma who underwent trabeculectomy with MMC from January 1, 2012, to December 31, 2015. The patients' demographics, baseline characteristics, ocular parameters, and postoperative outcomes were analyzed. Surgical success was classified into complete success (IOP = 4-21 mmHg without anti-glaucoma medication), qualified success (IOP = 4-21 mmHg with medication), and failure (IOP >21 mmHg or <4 mmHg). Factors associated with surgical failure were assessed using Cox regression analysis.</p><p><strong>Results: </strong>The cumulative probability of complete or qualified success at 8 years was 65.9% (95% CI: 59.9%, 71.9%); however, a significantly higher success rate was observed in the primary glaucoma group (75.1%) than in the secondary glaucoma group (47.4%) (p < 0.001). The secondary glaucoma group, particularly those with secondary closed-angle glaucoma, had the lowest success rates. Preoperative IOP, number of anti-glaucoma medications, and visual acuity were significantly different between the two groups. Etiologic factors associated with surgical failure included pseudo-exfoliation glaucoma (adjusted HR 3.23), neovascular glaucoma (adjusted HR 2.87), and secondary angle closure glaucoma (adjusted HR 2.62). Late complications were more prevalent in patients with secondary glaucoma than in those with primary glaucoma and included decreased visual acuity (5.43% vs 10.29%), hypotony (0.26% vs 1.14%), corneal decompensation (1.82% vs 3.40%), and bleb-related infection (0.19%).</p><p><strong>Conclusion: </strong>Trabeculectomy with MMC remains an effective surgical option for primary glaucoma, demonstrating better long-term outcomes compared to its outcomes in patients with secondary glaucoma. Risk factors for surgical failure include specific glaucoma etiologies. These findings would personalize management strategies to optimize surgical approaches based on predictive factors for surgical success.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1299-1311"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}