Clinical ophthalmology (Auckland, N.Z.)最新文献

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Clinical Characteristics and Prognosis of Juvenile Idiopathic Arthritis-Associated Uveitis: A Single-Center Retrospective Study. 青少年特发性关节炎相关性葡萄膜炎的临床特征和预后:一项单中心回顾性研究。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S529421
Li Li, Jun-Mei Zhang, Jiang-Hong Deng, Wei-Ying Kuang, Xiao-Hua Tan, Chao Li, Shi-Peng Li, Cai-Feng Li
{"title":"Clinical Characteristics and Prognosis of Juvenile Idiopathic Arthritis-Associated Uveitis: A Single-Center Retrospective Study.","authors":"Li Li, Jun-Mei Zhang, Jiang-Hong Deng, Wei-Ying Kuang, Xiao-Hua Tan, Chao Li, Shi-Peng Li, Cai-Feng Li","doi":"10.2147/OPTH.S529421","DOIUrl":"10.2147/OPTH.S529421","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the clinical features, risk factors, and outcomes of juvenile idiopathic arthritis-associated uveitis (JIA-U), aiming to improve early detection and management strategies.</p><p><strong>Methods: </strong>This study conducted a retrospective cohort analysis of JIA patients diagnosed and treated at the Department of Rheumatology at Beijing Children's Hospital (2016-2023), with subgroup evaluation of JIA-U cases.</p><p><strong>Results: </strong>Among 1494 JIA patients, 72 (4.82%) developed uveitis. The oligoarticular subtype (OJIA, 47.2%) and enthesitis-related arthritis (ERA, 27.8%) predominated. Uveitis onset occurred at a median of 10 months post-arthritis diagnosis (range: 0-86 months), with 93% manifesting within 4 years. Chronic anterior uveitis was the most frequent phenotype. ANA positivity and HLA-B27 were significantly associated uveitis. First-line acute management involved topical corticosteroids, with methotrexate escalation for severe cases and TNF-α inhibitors (adalimumab preferred) for refractory disease. Ocular complications arose in 25.9% during follow-up.</p><p><strong>Conclusion: </strong>Uveitis, often bilateral and insidious, is a common extra-articular manifestation of JIA. Absent arthritis signs may delay diagnosis, highlighting the need for regular screening and close rheumatology-ophthalmology collaboration to optimize outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2813-2820"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence of Ophthalmic Diagnoses and Exam Findings in Emergency Department Consults at Two Academic Hospitals. 两所专科医院急诊科会诊眼科诊断率及检查结果。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S530780
Mary Kim, Jennifer T Yu, Karine D Bojikian, Andrew Chen, Anthony T Chung, Thellea K Leveque, Shu Feng
{"title":"The Prevalence of Ophthalmic Diagnoses and Exam Findings in Emergency Department Consults at Two Academic Hospitals.","authors":"Mary Kim, Jennifer T Yu, Karine D Bojikian, Andrew Chen, Anthony T Chung, Thellea K Leveque, Shu Feng","doi":"10.2147/OPTH.S530780","DOIUrl":"10.2147/OPTH.S530780","url":null,"abstract":"<p><strong>Purpose: </strong>To report the prevalence of abnormal ophthalmic exam findings in Emergency Department (ED) ophthalmology consultations and provide foundational data for assessing ancillary diagnostic tools' effectiveness in an acute care setting.</p><p><strong>Patients and methods: </strong>We reviewed ophthalmic exam findings from consultations at Harborview Medical Center and University of Washington Medical Center EDs (Seattle, WA) between January 1, 2022, and December 31, 2022. Data included visual acuity (VA), intraocular pressure (IOP), visual field by confrontation (CVF), extraocular motility (EOM), pupil exam, slit lamp, and dilated exam findings. Descriptive statistics were calculated for continuous and categorical variables.</p><p><strong>Results: </strong>A total of 2087 consults for 1946 patients were included. VA was 20/40 or better in 61.9% of right eyes and 62.4% of left eyes. Afferent pupillary defect (APD) was present in 12.6% eyes. The average IOP was 16.1 mmHg for the right eye and 16.1 mmHg for the left eye. Abnormal EOM in either eye or both eyes were reported in 17.5% and 2.5%, respectively, while abnormal CVF were reported in 16.9%; with homonymous defects in 0.8%. The most common slit lamp exam findings included cataract (31.94%), conjunctival injection (31.2%), and superficial punctate epithelial erosions (29.6%). The most common funduscopic findings were retinal hemorrhage (14.0% peripheral and 6.3% macular), posterior vitreous detachment (9.7%), and retinal vascular attenuation (6.7%).</p><p><strong>Conclusion: </strong>This comprehensive report of findings of ED ophthalmic consultations can be used as a foundational pretest measure for guiding the implementation of appropriate ancillary diagnostic tools for emergency ophthalmic care.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2793-2802"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ophthalmologists' Perspectives on Immediate Sequential Bilateral Cataract Surgery (ISBCS): Attitudes, Practices, and Barriers in a Rapidly Growing Arab Economy. 眼科医生对即时序贯双侧白内障手术(ISBCS)的看法:快速增长的阿拉伯经济中的态度、实践和障碍。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S525286
Samar A Al-Swailem, Ahmed Mousa, Abdulrahman AlMatrafi, Sara AlHilali
{"title":"Ophthalmologists' Perspectives on Immediate Sequential Bilateral Cataract Surgery (ISBCS): Attitudes, Practices, and Barriers in a Rapidly Growing Arab Economy.","authors":"Samar A Al-Swailem, Ahmed Mousa, Abdulrahman AlMatrafi, Sara AlHilali","doi":"10.2147/OPTH.S525286","DOIUrl":"10.2147/OPTH.S525286","url":null,"abstract":"<p><strong>Purpose: </strong>To our knowledge, there is very little research on \"Immediate Sequential Bilateral Cataract Surgery\" (ISBCS) among ophthalmologists in the Arab countries. This study aimed to assess the attitudes, practices, and barriers related to ISBCS among board-certified ophthalmologists in a fast-growing Arab economy.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using a validated electronic questionnaire distributed to ophthalmologists practicing cataract and intraocular lens (IOL) surgery in Saudi Arabia. The survey was open from September 22 to October 21, 2024. The questionnaire included 25 specific questions divided into four domains: benefits and importance, controlling factors, surgeons' perspectives and selectivity, and reasons for adopting or rejecting ISBCS. Responses were collected via email, WhatsApp, and LinkedIn and analyzed based on the questionnaire planned structure. Descriptive statistics were used for analysis.</p><p><strong>Results: </strong>A total of 95 ophthalmologists participated, 73 (76.8%) male and 22 (23.2%) female. The majority (60%) had been practicing for more than 10 years, and 69.5% worked in government hospitals. The ISBCS was actively practiced by 17.9%, while 76.8% had never performed ISBCS, and 5.3% had previously practiced but discontinued. The main benefits of ISBCS reported included fewer hospital visits, faster visual rehabilitation, and reduced costs. The primary barriers were concerns about bilateral endophthalmitis, medico-legal risks, and refractive surprises. Some non-practicing ophthalmologists expressed willingness to adopt ISBCS under specific conditions, such as cases requiring general anesthesia or congenital cataracts.</p><p><strong>Conclusion: </strong>ISBCS remains underutilized among ophthalmologists in Saudi Arabia due to safety concerns and institutional policies. However, many practitioners recognize its potential benefits and may consider its adoption under specific conditions. Further research is needed to evaluate clinical outcomes, patient perspectives, patient satisfaction, opportunity cost, and cost-effectiveness to facilitate broader acceptance of ISBCS in this region.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2785-2792"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Age and Gender on Corneal Epithelial Thickness in Refractive Surgery Candidates. 年龄和性别对屈光手术患者角膜上皮厚度的影响。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-16 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S528185
Hagay Hayat, Shawn Sapir, Yaron Golzman, Michael Friger, Tzahi Sela, Gur Munzer, Igor Kaiserman
{"title":"Effect of Age and Gender on Corneal Epithelial Thickness in Refractive Surgery Candidates.","authors":"Hagay Hayat, Shawn Sapir, Yaron Golzman, Michael Friger, Tzahi Sela, Gur Munzer, Igor Kaiserman","doi":"10.2147/OPTH.S528185","DOIUrl":"10.2147/OPTH.S528185","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of age and gender on corneal epithelial thickness in healthy refractive surgery candidates.</p><p><strong>Methods: </strong>A retrospective, single-centered cross-sectional study in which we used the Anterior Segment (AS-OCT), MS39 -a device well-suited for corneal epithelial assessment, to measure the corneal epithelial thickness (CET) at five anatomical regions: the central zone and four peripheral quadrants (superior, inferior, nasal, and temporal) in consecutive healthy individuals evaluated for refractive surgery evaluation.</p><p><strong>Results: </strong>A total of 181 right eyes of individuals were divided into two groups based on their gender, and further into their age groups. The CET was significantly thicker in males compared to females in all four quadrants (p<0.005). Age also influenced the epithelial thickness, as with increasing age there was a thicker CET, in the inferior (p<0.05), nasal (p<0.05), temporal (p<0.001) and superior quadrants (p<0.05). No significant correlation was found with the central CET (p=0.06).</p><p><strong>Conclusion: </strong>Corneal epithelial thickness varies between males and females in all quadrants with males having significantly thicker epithelium. In addition, age is a factor that significantly influences the CET, showing an increase with advancing age. Refractive surgeons should take this into consideration especially when planning transepithelial refractive procedures.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2765-2771"},"PeriodicalIF":0.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Efficacy Between a Phospholipid-Hydroxypropyl Guar Nanoemulsion and Castor Oil-Based Lubricating Eyedrops. 磷脂-羟丙基瓜尔胶纳米乳与蓖麻油基润滑滴眼液的疗效比较。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S540474
Jay Mashouf, Keith Wan, Brad Hall
{"title":"Comparison of Efficacy Between a Phospholipid-Hydroxypropyl Guar Nanoemulsion and Castor Oil-Based Lubricating Eyedrops.","authors":"Jay Mashouf, Keith Wan, Brad Hall","doi":"10.2147/OPTH.S540474","DOIUrl":"10.2147/OPTH.S540474","url":null,"abstract":"<p><strong>Purpose: </strong>To compare dry eye symptoms using the SANDE questionnaire as well as corneal and conjunctival staining with two propylene glycol lubricating eyedrops that contain very different excipients.</p><p><strong>Methods: </strong>This was a single site, prospective, double-masked, randomized-controlled study with two arms comparing Systane Complete Multi-Dose Preservative Free (MDPF) eyedrops (Systane group) and Walgreen's Lubricant Balance eyedrops (WLB group). Participants were 18-65 years of age, had a total score of 20-55 inclusive on the Symptom Assessment iN Dry Eye (SANDE) questionnaire at the screening visit, and were not current contact lens wearers. Subjects were randomized to either Group. Data were collected for corneal and conjunctival staining, non-invasive tear break-up time (NITBUT), and global SANDE score.</p><p><strong>Results: </strong>A total of 70 participants completed the study (35 in each group). After 2 weeks of eyedrop use, the Systane group had a significantly greater reduction in global SANDE score (-9.9 ± 14.7) compared to the WLB group (-4.13 ± 8.6; p = 0.05). Also, the Systane group had a significantly greater reduction in total staining score (-2.8 ± 1.8) compared to the WLB group (-0.9 ± 1.5; p < 0.001). In addition, the Systane group had a greater increase in NITBUT (3.1 ± 2.9) compared to the WLB group (2.2 ± 4.5), but this was not significant (p = 0.32).</p><p><strong>Conclusion: </strong>The results of this study suggest that eyedrops with the same active ingredient, but different excipients, can have differences in performance. Participants reported less dry eye symptoms and presented with reduced clinical signs of dry eye with Systane Complete MDPF compared to those who used WLB. Systane Complete MDPF eyedrops may be a good option for practitioners to recommend for patients with mild to moderate symptoms of dry eye.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2759-2764"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraocular Lens Position Stability During Phacovitrectomy with Air or Gas Tamponade. 空气或气体填塞白内障玻璃体切除术中人工晶状体位置的稳定性。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S539958
Yuji Yoshikawa, Takashi Matsushima, Shunichiro Takano, Jun Makita, Kei Shinoda
{"title":"Intraocular Lens Position Stability During Phacovitrectomy with Air or Gas Tamponade.","authors":"Yuji Yoshikawa, Takashi Matsushima, Shunichiro Takano, Jun Makita, Kei Shinoda","doi":"10.2147/OPTH.S539958","DOIUrl":"10.2147/OPTH.S539958","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the stability of different intraocular lenses (IOLs) after phacovitrectomy with air or gas tamponade.</p><p><strong>Patients and methods: </strong>This retrospective cross-sectional study included 28 patients who underwent phacovitrectomy with air or sulfur hexafluoride gas tamponade and postoperative anterior segment optical coherence tomography assessments. Patients who received any DIB00V (Johnson & Johnson Surgical Vision, Inc. Irvine, CA, USA), XY-1 (HOYA Surgical Optics Co. Chromos, Singapore), or NX70s (Santen Pharmaceutical Co. LTD, Osaka, Japan) IOL implantation were analyzed. The anterior chamber depth (ACD) and IOL position values at each measurement (100%, 50%, 0%) and between IOLs were compared. The IOL displacement force (mN) was measured with a verification experiment and recorded at each 0.1 mm anterior movement until anterior displacement reached 0.5 mm.</p><p><strong>Results: </strong>The average patient age was 66 (59-73) years. ACD values increased progressively as the postoperative gas decreased for all IOLs. Compared to the preoperative ACD, postoperative ACD was significantly greater at 50% and 0% gas for all IOLs. The DIB00V had significantly larger ACD values than the XY-1 at 100% gas or air (P = 0.023) and the NX70s at 0% gas or air (P = 0.008). The IOL position gradually shifted significantly posteriorly for all IOLs as the gas or air disappeared. No significant change was observed in the DIB00V and NX70s between the gas 50% and gas 0% conditions (DIB00VP = 0.019 with Bonferroni correction, NX70s; P = 0.148 with Bonferroni correction). The DIB00V were significantly more posterior than the XY-1at 100% (P = 0.046).</p><p><strong>Conclusion: </strong>The DIB00V had greater IOL displacement force against push from the retinal surface compared to the XY-1 and NX70s and exhibited excellent z-axis stability in phacovitrectomy with air or gas tamponade.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2773-2783"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeatability of a Dual-Scheimpflug Placido Disc Corneal Tomographer/Topographer in Eyes with Keratoconus. 圆锥角膜双图式盘角膜层析仪/地形仪的重复性。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S530011
Anne Poulsen, Diane Haeji Jang, Mahmood Khan, Zaina Nabil Al-Mohtaseb, Michael Chen, Kalins Banerjee, Ingrid U Scott, Seth M Pantanelli
{"title":"Repeatability of a Dual-Scheimpflug Placido Disc Corneal Tomographer/Topographer in Eyes with Keratoconus.","authors":"Anne Poulsen, Diane Haeji Jang, Mahmood Khan, Zaina Nabil Al-Mohtaseb, Michael Chen, Kalins Banerjee, Ingrid U Scott, Seth M Pantanelli","doi":"10.2147/OPTH.S530011","DOIUrl":"10.2147/OPTH.S530011","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the repeatability of a combined Dual-Scheimpflug placido disc corneal tomographer/topographer (Ziemer Galilei G4) with respect to keratometric indices used to monitor progression of keratoconus (KCN).</p><p><strong>Methods: </strong>Patients with KCN were prospectively enrolled. For each eye lacking history of corneal surgery, 5 measurements were taken in succession. Eyes in which 3 or more measurements could be obtained (defined by the device's 4 image quality metrics) were included in the analysis. The repeatability limits (RL) and interclass correlation coefficients (ICC) were calculated for various parameters.</p><p><strong>Results: </strong>Thirty-two eyes from 25 patients met all image quality metrics, and 54 eyes from 38 patients met at least 3/4 criteria (all except the placido image quality metric). RLs for key parameters when 4/4 or ≥3/4 image quality metrics were met included: 0.37 and 0.77 diopters (D) for steep simulated keratometry, 0.79 and 1.65 D for maximum keratometry, 13.80 and 13.88 degrees for astigmatism axis, 0.64 and 0.56 µm for vertical coma magnitude, and 3.76 and 3.84 µm for thinnest pachymetry, respectively. The ICCs for all parameters were excellent (above 0.87) except for spherical aberration (0.77), which was still considered good.</p><p><strong>Conclusion: </strong>The dual-Scheimpflug placido disc corneal tomographer/topographer is highly repeatable in quantifying parameters used in monitoring KCN. Excellent placido images are difficult to capture in eyes with KCN, but when available, increase the reliability of the measurements. When clinicians find that a topographic index changes by more than the RLs defined herein, they can have confidence that this represents real change and may appropriately recommend interventions such as corneal cross-linking or intrastromal corneal ring segments.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2751-2758"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue Damage on Ocular Surface After Combined Phacoemulsification with Limbal Relaxing Incision Compared with Standard Phacoemulsification. 角膜缘放松切口联合超声乳化术与标准超声乳化术术后眼表组织损伤的比较。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S534006
Haiyan Wang, Xinlu Yu, Yanan Li, Lingjuan Sun, Mingqi Liu, Xiongwei Zhang, Ruibo Yang
{"title":"Tissue Damage on Ocular Surface After Combined Phacoemulsification with Limbal Relaxing Incision Compared with Standard Phacoemulsification.","authors":"Haiyan Wang, Xinlu Yu, Yanan Li, Lingjuan Sun, Mingqi Liu, Xiongwei Zhang, Ruibo Yang","doi":"10.2147/OPTH.S534006","DOIUrl":"10.2147/OPTH.S534006","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of phacoemulsification combined with LRIs on the ocular surface at different postoperative time.</p><p><strong>Design: </strong>This study was designed as a retrospective analysis. Medical records of patients who had undergone relevant surgeries in the past were reviewed. Patients were divided into two groups based on the surgical procedures they had received: one group was those who had undergone phacoemulsification combined with LRIs (experimental group), and the other was those who had only received phacoemulsification (control group).</p><p><strong>Methods: </strong>We retrospectively selected 80 patients (80 eyes) who had received cataract treatment. Among them, 41 eyes belonged to the experimental group and 39 eyes to the control group, which were grouped according to the degree of astigmatism as recorded in the medical files. The Tear Film Objective Scatter Index (TF-OSI), tear film break-up time (BUT), Schirmer I test, and Ocular Surface Disease Index (OSDI) scores were utilized to retrospectively evaluate the ocular surface conditions of these patients.</p><p><strong>Results: </strong>A total of 80 patients (80 eyes) were selected for phacoemulsification treatment with cataract, TF-OSI value of the experimental group was higher than that of the control group at 1 day, 1 week, 6 weeks after surgery (P < 0.05). BUT value was lower than that of the control group at 1 day, 1 week, 6 weeks after surgery (P < 0.05). Schirmer I test value was lower than that of the control group at 1 week and 6 weeks after surgery (P < 0.05). OSDI scores were higher than that of the control group 1 week, 6 weeks and 3 months after surgery (P < 0.05).</p><p><strong>Conclusion: </strong>Phacoemulsification with LRIs may cause more tissue damage on the ocular surface compared to standard phacoemulsification alone.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2743-2750"},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-Decade Retrospective Analysis of Postoperative Endophthalmitis at a Tertiary Care Academic Center: Microbial Spectrum, Treatment Modalities, and Visual Outcomes. 三级医疗学术中心术后眼内炎的二十年回顾性分析:微生物谱、治疗方式和视力结果。
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S535966
Thanaporn Kritfuangfoo, Ratima Chokchaitanasin, Tharikarn Sujirakul, Thitiporn Thongborisuth, Boontip Tipsuriyaporn
{"title":"Two-Decade Retrospective Analysis of Postoperative Endophthalmitis at a Tertiary Care Academic Center: Microbial Spectrum, Treatment Modalities, and Visual Outcomes.","authors":"Thanaporn Kritfuangfoo, Ratima Chokchaitanasin, Tharikarn Sujirakul, Thitiporn Thongborisuth, Boontip Tipsuriyaporn","doi":"10.2147/OPTH.S535966","DOIUrl":"10.2147/OPTH.S535966","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the causative microorganisms, treatment modalities, visual outcomes, and factors influencing the results of postoperative endophthalmitis at a major tertiary referral eye care facility in Thailand.</p><p><strong>Patients and methods: </strong>A retrospective review was conducted on patients diagnosed with postoperative endophthalmitis over a 20-year period. The collected data included demographic characteristics, endophthalmitis classification, causative organisms, treatment modalities, and final visual acuity. Factors associated with improved visual outcomes were explored.</p><p><strong>Results: </strong>This study included 163 eyes (163 patients). Eighty-seven cases (53.4%) were acute-onset, while the rest were delayed-onset. Cataract surgery was the most common prior intraocular procedure. Microorganisms were identified by culture in 29.4% of cases. Coagulase-negative <i>Staphylococcus</i> species were predominant among acute-onset cases (57.7%), followed by <i>Enterococcus faecalis</i> (15.4%); coagulase-negative <i>Staphylococcus</i> species also were predominant among delayed-onset cases (18.9%). The most common treatment was immediate pars plana vitrectomy (PPV) with intravitreal injection. Significant improvements in visual acuity (VA) were observed in the immediate and delayed PPV groups, with mean improvements of 0.80 logMAR (p < 0.001) and 0.87 logMAR (p = 0.001), respectively. Globe salvage was achieved in 96.3% of cases, with a median final VA of 20/200. Visual improvement, stability, and deterioration were observed in 61.2%, 11.5%, and 27.4% of cases, respectively. Factors associated with poor visual outcomes were diabetes mellitus (p=0.019), visual acuity at initial presentation of 20/200 or worse (p<0.001), and delayed-onset postoperative endophthalmitis (p=0.001).</p><p><strong>Conclusion: </strong>Immediate PPV with intravitreal injection remains the most common and effective treatment for postoperative endophthalmitis, achieving significant visual acuity improvement and high rates of globe salvage. Visual outcomes were significantly influenced by diabetes mellitus, poor visual acuity at initial presentation, and delayed-onset endophthalmitis, underscoring the importance of timely and tailored management strategies.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2729-2742"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Cataract History with Dry Eye Disease Signs and Symptoms in the DREAM Study. DREAM研究中白内障病史与干眼病体征和症状的关系
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S541618
Aaron T Zhao, Jocelyn He, Penny A Asbell, Vatinee Y Bunya, Gui-Shuang Ying
{"title":"Association of Cataract History with Dry Eye Disease Signs and Symptoms in the DREAM Study.","authors":"Aaron T Zhao, Jocelyn He, Penny A Asbell, Vatinee Y Bunya, Gui-Shuang Ying","doi":"10.2147/OPTH.S541618","DOIUrl":"10.2147/OPTH.S541618","url":null,"abstract":"<p><strong>Background: </strong>Dry eye disease (DED) and cataracts are highly prevalent ocular conditions, particularly among older adults. However, the relationship between cataracts, cataract surgery, and DED severity remains poorly understood. This study aimed to assess the associations between cataract history and DED signs and symptoms in participants with moderate-to-severe DED.</p><p><strong>Methods: </strong>This is a secondary analysis of data from a double-blind randomized control trial of participants (n = 535) with moderate-to-severe DED in the DREAM Study. At baseline, cataract history and patient characteristics were collected; DED signs and symptoms were assessed at baseline, 6 and 12 months. Cataract history was classified as: no history of cataracts, ongoing cataracts (clinically diagnosed cataracts without surgical intervention), or history of cataract surgery >6 months prior to enrollment. Associations between cataract history and DED signs and symptoms were evaluated by univariate and multivariate regression analysis.</p><p><strong>Results: </strong>Among 1070 eyes from 535 participants, 646 eyes (60%) had no history of cataracts, 244 eyes (23%) had ongoing cataracts, and 180 eyes (17%) had a history of cataract surgery >6 months prior. On univariate analysis of the combined data from baseline, 6 and 12 months, corneal staining scores were significantly worse in eyes with a history of cataract surgery than eyes with ongoing cataracts and eyes without history of cataracts (4.08 vs 3.63 vs 3.14; <i>P</i>=0.005). However, the difference became non-significant after adjustment by age alone (3.62 vs 3.38 vs 3.37, <i>P</i>=0.71) or by factors associated with DED severity (<i>P</i>=0.72). In multivariate analysis, meibomian gland dysfunction was significantly worse in eyes with no history of cataracts than in eyes with ongoing cataracts or with history of cataract surgery (3.1 vs 2.7 vs 2.6; <i>P</i>=0.02).</p><p><strong>Conclusion: </strong>Cataract surgery was not independently associated with worse DED symptoms and signs. This indicates that exacerbations of DED severity following cataract surgery are either age-related or transient in patients with moderate-to-severe DED.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2709-2718"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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