Clinical ophthalmology (Auckland, N.Z.)最新文献

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An Analysis of Ocular Trauma Resulting From Pediatric Sports Injuries.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S493655
Aysha Chaudhary, Evan W Carr, Frank Bogan, Jeffrey Xiao Liu, Amir R Hajrasouliha
{"title":"An Analysis of Ocular Trauma Resulting From Pediatric Sports Injuries.","authors":"Aysha Chaudhary, Evan W Carr, Frank Bogan, Jeffrey Xiao Liu, Amir R Hajrasouliha","doi":"10.2147/OPTH.S493655","DOIUrl":"https://doi.org/10.2147/OPTH.S493655","url":null,"abstract":"<p><strong>Purpose: </strong>Although sports participation among pediatric patients benefits overall development, the risks of ocular trauma are often overlooked. This retrospective cohort study investigated sports groups to determine which caused the greatest ocular trauma and initial presenting visual acuity (VA) impairment.</p><p><strong>Patients and methods: </strong>1,290 pediatric ocular traumas in two Indianapolis tertiary care centers over a 10-year period were collected and stratified based on sport category, injury type, age, and need for surgical intervention. Chi-square analysis and Fisher exact testing were used to determine each variable's significance.</p><p><strong>Results: </strong>Ocular injuries were most commonly attributed to baseball (38.5%), basketball (16.9%), and soccer (14.9%). The most common ocular diagnoses were contusions (82.4%) and hyphemia (8.1%). Orbital fractures were the most common diagnosis requiring surgery (54.5%) with baseball as the most common cause (67.0%) of these fractures. Analysis of significant visually impairing traumas indicated that golf and archery were the most detrimental in initial presenting VA followed by football and baseball. Lastly, children aged 0-11 years old (p = <0.01) most commonly had injuries attributable to baseball (p = <0.01) whereas older children aged 12-18 more commonly had injuries attributable to soccer (p= 0.04) and football (p=0.04).</p><p><strong>Conclusion: </strong>With our study illustrating that archery and golf were the most detrimental on initial presenting VA while baseball was the most common cause of impactful injuries, particularly among children aged 3-11 years, safety guidelines should include mandatory eye protection to decrease the risk of sport-related ocular injury.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"507-517"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S505086
Suping Wu, Wenting Wang, Lei Liu, Wei Wang, Keke Jiang, Chuanzhi Peng, Huixin Sun, Jie Zhang
{"title":"Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome.","authors":"Suping Wu, Wenting Wang, Lei Liu, Wei Wang, Keke Jiang, Chuanzhi Peng, Huixin Sun, Jie Zhang","doi":"10.2147/OPTH.S505086","DOIUrl":"https://doi.org/10.2147/OPTH.S505086","url":null,"abstract":"<p><p>Morning glory syndrome (MGS) is a rare congenital optic disc malformation characterized by a distinctive funnel-shaped optic disc resembling a blooming morning glory flower, typically diagnosed in childhood or adolescence and primarily presenting unilaterally, although bilateral cases have been reported. The anomaly features an enlarged optic disc, radiating blood vessels, and surrounding excavation, leading to visual impairment that can range from mild to profound. The etiology of MGS is not fully understood but has been associated with genetic factors, particularly mutations in the PAX6 and PAX2 genes, which play critical roles in eye development. MGS is often linked with other ocular and systemic anomalies, including retinal detachment, a significant complication that may be exudative, tractional, or rhegmatogenous. Surgical interventions are generally employed to manage complications, especially retinal detachments, with procedures such as vitrectomy, paraoptic disc laser photocoagulation, and the use of silicone oil or gas tamponade, though success rates can vary widely. Long-term outcomes for patients with MGS largely depend on the severity of associated complications and the timing of interventions; while some individuals may attain reasonable visual function post-treatment, others may continue to experience challenges due to the underlying malformation and its consequences. Thus, MGS remains a complex condition requiring a multidisciplinary approach for effective management and enhanced patient outcomes, emphasizing the need for continued research into its genetic underpinnings and optimal treatment strategies to improve understanding and care for those affected.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"459-468"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S497111
Concepción Santacruz Valdés, Efrén Raúl Ponce-Rosas, Maria C Jimenez-Martinez
{"title":"Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity.","authors":"Concepción Santacruz Valdés, Efrén Raúl Ponce-Rosas, Maria C Jimenez-Martinez","doi":"10.2147/OPTH.S497111","DOIUrl":"https://doi.org/10.2147/OPTH.S497111","url":null,"abstract":"<p><strong>Introduction: </strong>Acute adenoviral conjunctivitis is a disease with mild to severe clinical manifestations. Animal models have provided insight into the role of the innate immune system in clinical damage, but the human immune response at the ocular surface remains poorly understood. Therefore, this study aimed to establish the relationship between tear cytokine levels and disease severity in patients with epidemic keratoconjunctivitis (EKC).</p><p><strong>Methods: </strong>Fourteen consecutive patients with EKC, confirmed with HAdV8 infection, were included. Ocular characteristics were documented, and each patient's eye was classified as having more or less severe disease. After tear sampling, levels of cytokines IL-8, IL-6, IL-1b, IL-10, IL-12, and TNF-a were measured using a cytometric bead array.</p><p><strong>Results: </strong>Our results showed the expression of proinflammatory cytokines in EKC-affected eyes. IL-6, IL-8, and IL-12 significantly correlated with the total clinical ophthalmological score. In the more severely affected eyes, IL-8 and IL-6 significantly correlated with conjunctival hyperemia, and IL-6 correlated with conjunctival swelling. In the less severely affected eyes, inflammatory response, conjunctival hyperemia, and conjunctival hemorrhages were significantly correlated with IL-12 and TNF-a, and ocular discharge was significantly correlated with all tear cytokines. IL-10 was detected in both eyes, suggesting a possible regulatory counterbalance.</p><p><strong>Discussion: </strong>This study offers novel insights into the pathophysiology of human adenoviral keratoconjunctivitis and its association with clinical data.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"439-448"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S504956
Varis Ruamviboonsuk, Wijak Kongwattananon, Natthaya Chuaypen
{"title":"Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection.","authors":"Varis Ruamviboonsuk, Wijak Kongwattananon, Natthaya Chuaypen","doi":"10.2147/OPTH.S504956","DOIUrl":"https://doi.org/10.2147/OPTH.S504956","url":null,"abstract":"<p><strong>Purpose: </strong>Intravitreal brolucizumab, approved for neovascular age-related macular degeneration (nAMD), may trigger immune responses leading to intraocular inflammation (IOI) by increasing pro-inflammatory cytokines. This study evaluates cytokine levels in the aqueous humor of patients before and after intravitreal brolucizumab injection.</p><p><strong>Patients and methods: </strong>Fourteen eyes of fourteen participants with nAMD or polypoidal choroidal vasculopathy (PCV) and who received intravitreal brolucizumab injection were included. Aqueous humor was collected before and 1 month following the injection. The aqueous cytokine profile was analyzed using a bead-based multiplex immunoassay. Paired <i>t</i>-test and Wilcoxon-signed rank test were used to analyze the results.</p><p><strong>Results: </strong>Ten eyes were diagnosed with PCV, and four were nAMD. The aqueous IL-8 and IL-22 levels were significantly increased after intravitreal brolucizumab injection with a mean change of 18.2 ± 32.57 pg/mL (95% CI -0.61 to 37.01, p = 0.04) and 15.46 ± 24.14 pg/mL (95% CI 1.53-29.40, p = 0.03), respectively. VEGF-A was significantly decreased with a mean change of -915.4 ± 831.72 pg/mL (95% CI -1395.62 to -435.18, p < 0.01). One patient was diagnosed with IOI, and the cytokine profile showed increased in aqueous pro-inflammatory cytokines (Exotaxin, G-CSF, IL-8, IL-10, IL-22, IL-10, MCP-1 and TNF- α) and decreased in VEGF-A level compared with baseline.</p><p><strong>Conclusion: </strong>Our study demonstrated a significant increase in aqueous pro-inflammatory cytokines in eyes treated with intravitreal brolucizumab. Nearly all eyes studied showed no clinical signs of intraocular inflammation. The results suggested that type IV cell-mediated hypersensitivity could play a role in IOI following intravitreal brolucizumab injection.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"427-437"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S504247
Matthew S Porter, Addie Flowers, Brandon P Wood, Mark J Gallardo
{"title":"Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma.","authors":"Matthew S Porter, Addie Flowers, Brandon P Wood, Mark J Gallardo","doi":"10.2147/OPTH.S504247","DOIUrl":"https://doi.org/10.2147/OPTH.S504247","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of canaloplasty via an ab-interno technique using the iTrack (Nova Eye Medical, Fremont, USA) combined with microtrabecular bypass stent surgery with the Hydrus microstent (Ivantis, Inc, Irvine, CA) following cataract surgery (CE) in patients with primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>A retrospective, two-center, case series of 51 POAG eyes that underwent phacoemulsification followed by canaloplasty combined with microtrabecular bypass stent surgery. Eyes were categorized according to IOP and disease severity. A subgroup of patients on 3+ medications at baseline was included. Primary end points included the mean IOP and mean number of medications at 12 months, 24 months and at the last follow-up.</p><p><strong>Results: </strong>Baseline IOP (mmHg) and number of medications were 19.1±4.0 and 2.3±1.2 and reduced to 13.9±2.6 (p<0.001) and 1.2±1.4 (p<0.001) at 12 months, 13.7±2.0 and 1.5±1.5 (p<0.001, p=0.008, respectively) at 24 months (n=31) and 14.4±3.2 and 2.1±1.5 (p<0.001, p=0.5, respectively) at 36 months. In the uncontrolled group (n=27), baseline IOP and number of medications were 21.9±3.1 and 1.9±1.3 and reduced to 14.6±4.2 (p=0.006) and 1.7±1.6 (p=0.821) at 36 months postoperatively. Baseline IOP and number of medications of severe patients (n=12) were 19.0±4.8 and 1.9±1.1. IOP reduced to 12.8±2.4 (p=0.005) at 12 months while the number of medications did not show any statistically significant change: 1.9±1.6 (p=0.4). No eyes underwent additional glaucoma surgery in the study period.</p><p><strong>Conclusion: </strong>Canaloplasty combined with microtrabecular bypass stent surgery following cataract extraction demonstrated efficacy in reducing IOP and medication burden up to 24 months postoperatively. IOP reduction was also sustained up to 36 months postoperatively. The combined MIGS procedure is also effective in eyes with uncontrolled glaucoma.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"469-481"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S505856
Benjamin Paik, Chun Hau Chua, Leonard W Yip, Vivien C H Yip
{"title":"Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis.","authors":"Benjamin Paik, Chun Hau Chua, Leonard W Yip, Vivien C H Yip","doi":"10.2147/OPTH.S505856","DOIUrl":"https://doi.org/10.2147/OPTH.S505856","url":null,"abstract":"<p><strong>Topic: </strong>To analyse the safety and efficacy of minimally invasive glaucoma surgeries (MIGS) in lowering IOP and medication burden in primary angle closure (PAC) or primary angle closure glaucoma (PACG).</p><p><strong>Clinical relevance: </strong>MIGS is off-label in angle closure, as implantation of the device is difficult when there is iridotrabecular contact. However, access to the trabecular meshwork may be established with cataract removal or goniosynechiolysis. While MIGS can be performed in the same setting as phacoemulsification (MIGS-phaco), it remains controversial if the combined procedure confers a significant advantage over standalone phacoemulsification.</p><p><strong>Methods: </strong>We performed a systematic search of MEDLINE, EMBASE, and Cochrane library for studies reporting outcomes of MIGS in PAC or PACG. Our main outcome measures were IOP-lowering from baseline and medication reduction, at 1 year. We performed meta-analyses of these outcomes using weighted mean differences (WMD) under random-effects models. Our secondary outcome was complication rate.</p><p><strong>Results: </strong>Twenty-three studies comprising 875 patients were included in our review, from which 15 (590 patients) were included in meta-analysis. MIGS (with and without phacoemulsification) demonstrated a weighted mean reduction in IOP of 7.71 mmHg (95% CI: 5.16-10.26), and in medication of 1.57 (95% CI: 1.17-1.96), both at 1 year. Subgroup analyses revealed the superiority of AIT over endoCPG and iStent in both IOP-lowering (p<0.02) and medication burden (p<0.01). Comparison analysis between MIGS-phaco vs standalone phacoemulsification revealed superiority of MIGS-phaco in reducing medication burden (WMD 0.59, 95% CI: -0.04-1.22) and to a limited extent, IOP-lowering (WMD 1.22; 95% CI: -0.96-3.39) up till 1 year. Overall complication rate was 141/875 (16%) after excluding transient self-resolving hyphema.</p><p><strong>Conclusion: </strong>MIGS brings about sustained reduction in IOP and medication burden with favourable side-effect profile in angle closure eyes. MIGS-phaco may be superior to standalone phacoemulsification. MIGS should be thoroughly considered for mild-moderate PACG with coexisting cataract before pursuing more invasive surgical approaches.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"483-506"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Artery Occlusion Associated with Prepapillary Arterial Loop: An Isolated Ocular Disease? Case Report and Literature Review.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S509248
Ahmad M Mansour, Maurizio Battaglia Parodi, Antônio Marcelo Barbante Casella, Wajiha J Kheir, Ziad Fayez Bashshur
{"title":"Retinal Artery Occlusion Associated with Prepapillary Arterial Loop: An Isolated Ocular Disease? Case Report and Literature Review.","authors":"Ahmad M Mansour, Maurizio Battaglia Parodi, Antônio Marcelo Barbante Casella, Wajiha J Kheir, Ziad Fayez Bashshur","doi":"10.2147/OPTH.S509248","DOIUrl":"https://doi.org/10.2147/OPTH.S509248","url":null,"abstract":"<p><strong>Purpose: </strong>When branch retinal artery occlusion is linked to prepapillary artery loop, is a systemic work-up necessary?</p><p><strong>Methods: </strong>Case Report and literature review. The databases searched were MEDLINE OVID, Scopus, Web of Science, and Embase. The search was for all relevant articles published from inception until October 31, 2024.</p><p><strong>Results: </strong>A total of 33 cases of prepapillary artery loop with retinal artery occlusion were reviewed. Median age at diagnosis was 24 years (range 10-64). Twenty five cases had no systemic disease while 9 had unrelated systemic disorder. Systemic workup was carried in 17 cases and was negative. The location of the branch retinal artery occlusion was inferior in 21 cases, superior in 6 cases, and combined superior and inferior in 2 cases. Paracentral acute middle maculopathy was noted in 2 cases. Precipitating factors included exercise in 4 cases, head trauma in 2 cases, blunt ocular trauma, severe sneezing, ocular rubbing and sun exposure in 1 case each.</p><p><strong>Conclusion: </strong>A branch retinal artery occlusion linked to a prepapillary loop appears as a distinct ocular condition in young healthy individuals. There is no definite need for additional diagnostic testing in such patients with a negative systemic history.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"449-458"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-Month Outcomes of SMILE Pro with the VISUMAX 800 for Myopic Astigmatism in a Large Population.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S502915
Hong Son Cung, Lan Huong Thi Tran, Thanh Ngoc Tran
{"title":"Three-Month Outcomes of SMILE Pro with the VISUMAX 800 for Myopic Astigmatism in a Large Population.","authors":"Hong Son Cung, Lan Huong Thi Tran, Thanh Ngoc Tran","doi":"10.2147/OPTH.S502915","DOIUrl":"10.2147/OPTH.S502915","url":null,"abstract":"<p><strong>Purpose: </strong>To report the visual and refractive outcomes of small-incision lenticule extraction (SMILE) Pro using a 2 MHz femtosecond laser for myopic astigmatism in a large population of Vietnamese patients.</p><p><strong>Methods: </strong>This was a retrospective clinical study of subjects that underwent keratorefractive lenticule extraction (KLEx) with the VISUMAX 800 at Hong Son Eye Hospital (Ha Noi, Vietnam) between June 2023 and October 2023. Primary outcome measures of monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and refraction, including vector analysis, were evaluated at 3-months postoperatively. Secondary outcome measures of intraoperative and postoperative complications were also recorded.</p><p><strong>Results: </strong>A total of 765 eyes from 389 patients (60.66% women, mean age of 23.54±5.20 years) were analyzed 3 months after surgery. The mean preoperative spherical equivalent refraction was -5.98±2.26 D. The postoperative spherical equivalent refraction was within ±0.50 D of the intended target in 81% and within ±1.00 D in 97% of eyes. The mean spherical equivalent refraction was -0.11±0.45 D. UDVA was 20/25 or better in 92% and 20/32 or better in 97% of eyes. The mean postoperative UDVA and CDVA values were 0.05±0.09 and 0.00±0.02 logMAR, respectively. There was no change in CDVA in 99% of eyes. Efficacy index was 0.92, and safety index was 1.00. One eye (0.13%) had a suction loss, which resulted in a lenticule remnant. No other complications were reported during surgery or the postoperative follow-up period.</p><p><strong>Conclusion: </strong>The current study, carried out on a large cohort of Asian patients, showed SMILE Pro with the VISUMAX 800 was safe and effective for treating myopic astigmatism.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"417-425"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S503060
Mark R Barakat, Henry M Kwong, Gelson Marcon, Olivia E O'Leary, Liliana P Paris, Petrick Schneider, Yannan Tang, Jordan M Graff
{"title":"Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe.","authors":"Mark R Barakat, Henry M Kwong, Gelson Marcon, Olivia E O'Leary, Liliana P Paris, Petrick Schneider, Yannan Tang, Jordan M Graff","doi":"10.2147/OPTH.S503060","DOIUrl":"10.2147/OPTH.S503060","url":null,"abstract":"<p><strong>Purpose: </strong>Faricimab, the first bispecific antibody designed for intraocular use, is approved for the treatment of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). Here, we report the usability of a novel faricimab 6 mg pre-filled syringe (PFS) configuration that has been designed specifically for intravitreal use.</p><p><strong>Patients and methods: </strong>A simulated-use human factors validation study enrolling 15 retina specialists and 15 ophthalmic assistants was conducted in a market research facility configured to represent an ophthalmology clinic. Participants' ability to complete tasks related to package handling, dose preparation, and injection of a faricimab 6 mg dose into a polymer eye using the PFS was assessed. In a second Phase 3b, single-arm, actual-use study, the ability of seven retina specialists and six ophthalmic assistants to prepare and administer the PFS in accordance with the instructions for use was assessed. Injections were performed into single eyes of 35 patients with nAMD or DME in three US clinics and patients were followed for 7 days for safety reporting (ClinicalTrials.gov identifier: NCT05569148).</p><p><strong>Results: </strong>In the simulated-use study, most retina specialists and ophthalmic assistants completed all tasks deemed essential for PFS preparation and administration correctly and without error. Of the 22 tasks, the pass rate was 86.7-100%; 16 tasks had a pass rate of 100%. No use errors were observed during the actual-use study. One patient experienced one mild adverse event of eye irritation that resolved the same day and was deemed unrelated to the study drug.</p><p><strong>Conclusion: </strong>Participants were able to safely and correctly prepare and administer a faricimab 6 mg dose using the PFS in accordance with the instructions for use, under realistic conditions representing the real world. The faricimab 6 mg PFS may therefore offer a more convenient, safe-handling alternative to vial administration.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"395-406"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With Dry Eye Disease.
Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.2147/OPTH.S489669
Seong-Jae Kim, Woong-Sun Yoo, Lee-Ha Kwon, Rock Bum Kim, Hyeon-Jeong Yoon, Kyung Chul Yoon
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