Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Rotational Stability After Implantation of an Aspheric Toric Monofocal IOL with a Double C-Loop Haptic Design in Normal and High Axial Lengths.","authors":"Robert Edward T Ang, Pedro Tañá-Rivero, Francisco Pastor-Pascual, Pavel Stodulka, Martin Slovak, Manfred Tetz, Isaak Fischinger, Jorge Cazal, María Gessa, Marta Ibarz-Barberá, Detlef Holland, Thomas Groneberg","doi":"10.2147/OPTH.S530593","DOIUrl":"https://doi.org/10.2147/OPTH.S530593","url":null,"abstract":"<p><strong>Purpose: </strong>This study focuses on the analysis of the rotational stability after implantation of a biconvex aspheric toric monofocal intraocular lens (IOL) with a double C-loop haptic-design in eyes with normal versus high axial lengths.</p><p><strong>Methods: </strong>This was a prospective comparative study including 150 eyes with corneal astigmatism (≥0.75D) implanted with the biconvex aspheric monofocal PODEYE toric IOL and assessed up to 1 year after surgery. From these 150 eyes, 81 and 69 eyes belonged to normal (≤23.9mm) and high (≥24mm) axial lengths, respectively. About 4-6 and 11-13 months postoperatively, refraction and rotational stability of the PODEYE toric IOL were evaluated to find possible differences among both groups.</p><p><strong>Results: </strong>At the last postoperative-visit, 74.07% of eyes were within ±0.50D and 95.06% of eyes were within ±1.00D of the target-refraction for the normal group and 92.75% and 100% for the high axial length group, respectively. For the normal group, 77.78% and 96.30% of eyes had a postoperative refractive cylinder of ≤0.50D and ≤1.00D, respectively; and for the high axial length group these percentages were 84.05% and 100%, respectively. About 81.84% of eyes in the normal and 94.20% of eyes in the high axial length group were <5 degrees of the intended axis. The mean IOL rotation was 2.93 ± 2.48 degrees in the normal axial length group, and 2.17 ± 1.73 degrees in the high axial length group. Based on the mixed ANOVA results, there is no evidence of a significant difference in IOL rotation over time, nor is there evidence that axial length plays a statistically significant role in rotational stability between 4-6 and 11-13 months postsurgery. Both groups exhibited similar and stable rotation outcomes.</p><p><strong>Conclusion: </strong>Our results reveal that the biconvex aspheric monofocal PODEYE toric IOL with double C-loop haptic-design shows excellent rotational stability without significant differences between eyes with normal and high axial lengths.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2393-2403"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Active Fluidics System on RNFL and GCL in Phacoemulsification.","authors":"Alessandra Di Maria, Vanessa Ferraro, Gianmaria Barone, Massimo Vitali, Costanza Tredici, Alessandro Gaeta, Paolo Vinciguerra, Filippo Confalonieri","doi":"10.2147/OPTH.S526195","DOIUrl":"https://doi.org/10.2147/OPTH.S526195","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate whether cataract surgery performed using the Active Fluidics^® system under low-pressure settings has any measurable impact on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), with particular attention to early postoperative structural changes and safety outcomes.</p><p><strong>Materials and methods: </strong>Inclusion criteria comprised age-related cataract N4 NC4, BCVA ≤ 0.6, and subjects aged >18 years. Exclusion criteria encompassed glaucoma therapy, anatomical pathologies, or retinal history. Preoperatively, participants underwent comprehensive ophthalmological assessment. Macular GCL and peripapillary RNFL evaluations were conducted using the Heidelberg Spectralis^® OCT. Visual field (VF) tests were performed with Zeiss Humphrey Field Analyzer 3. Phacoemulsification surgery was performed using the Alcon Centurion Vision System. A month later, participants underwent ophthalmological re-evaluation, repeating OCT and VF testing.</p><p><strong>Results: </strong>No significant differences were found before and after surgery in GCL. Regarding RNFL thickness, a significant increase was observed in several sectors. Changes in the computerized VF test showed variations, but these were not statistically significant.</p><p><strong>Conclusion: </strong>We found no significant changes in GCL nor retinal function. However, there was an increase in peripapillary RNFL, likely due to underestimation caused by lens opacification before surgery. Overall, the Alcon^® system allows for safe surgery with reliable long-term results and minimal retinal damage.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2383-2391"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micropulse Cyclophotocoagulation versus Ultrasound Cycloplasty in a Tertiary Eye Care Center in Riyadh, Saudi Arabia.","authors":"Abdulrahman Abdullah Alasqah, Raghad Harran Alonazi, Shefa Abdullah Alamoudi, Nayef Diyab Alotaiby","doi":"10.2147/OPTH.S519777","DOIUrl":"10.2147/OPTH.S519777","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy, safety and outcomes of micropulse cyclophotocoagulation (MP-CPC) to ultrasound cycloplasty (UCP) in patients referred to a tertiary eye care center in Riyadh, Saudi Arabia.</p><p><strong>Patients and methods: </strong>A retrospective study evaluated data from patients who had undergone MP-CPC or UCP from January 2017 to October 2023. Patients who lost to follow up and patients with incomplete medical reports were excluded from the study. Data was collected for day 1, 2nd week, 1 month and 3, 6, and 12 months postoperatively. At each visit, data was collected on intraocular pressure (IOP), corrected distance visual acuity (CDVA), medications and possible complications. Data was compared between groups. P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Out of 139 eyes, 65 underwent UCP, and 74 underwent MP-CPC. IOP in the UCP group decreased from 29.67±9.82 mmHg preoperatively to 21.00±6.78 mmHg at one year postoperatively and in the MP-CPC group, IOP decreased from 28.44±9.46 mmHg to 20.41±8.77 mmHg respectively. In the UCP group, at the 1-year follow-up, vision remained unchanged from the preoperative levels in 6 eyes (27.3%), while 2 eyes (9.1%) lost 1 line of vision, and 8 eyes (36.4%) experienced a loss of ≥2 lines. In the MP-CPC group, at the 1-year follow-up, vision remained unchanged in 24 eyes (43.6%), 2 eyes (3.6%) lost 1 line, and 20 eyes (36.4%) had a loss of ≥2 lines. The number of antiglaucoma medications at 1 year postoperatively did not differ between groups. The qualified success rate at 1 year was similar between groups.</p><p><strong>Conclusion: </strong>Both UCP and MP-CPC are safe and effective for reducing IOP in refractory glaucoma, with similar reductions observed between the two techniques. Visual outcomes and qualified success rates were comparable between UCP and MP-CPC.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2373-2381"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Future Projections of Vitreoretinal Surgery in a Tertiary Hospital in China (2005-2022).","authors":"Chin-Ling Tsai, Baoyi Liu, Yaping Liu, Zhuojun Xu, Zhuangling Lin, Ziye Chen, Yuan Ma, Yuan Liu, Zitong Chen, Lan Jiang, Zijian Qin, Kunbei Lai, Tao Li","doi":"10.2147/OPTH.S522293","DOIUrl":"10.2147/OPTH.S522293","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze past trends and project future trajectories of vitreoretinal surgery in China.</p><p><strong>Methods: </strong>A single-institution, retrospective analysis of vitreoretinal surgeries conducted at Zhongshan ophthalmic center (ZOC), Sun Yat-sen University, from 2005 to 2022, utilizing ZOC's inpatient database. Patients hospitalized in the retinal surgery department were included. The number of surgeries was stratified by final diagnosis, and a time series forecasting model was employed to predict the number of patients undergoing vitreoretinal surgery up to and including the year 2032.</p><p><strong>Results: </strong>The number of patients undergoing vitreoretinal surgery increased nearly fourfold from 2005 to 2022, reaching a total of 5600 vitreoretinal surgeries in 2022. The majority of indication was given for the treatment was rhegmatogenous retinal detachment (RRD). Among the diagnosis categories, macular diseases (MD) increased by 15.61%, and diabetic retinopathy (DR) by 11.99% during the study period. Vitreoretinal surgeries are projected to increased annually, with an estimated 9231 vitreoretinal surgeries by 2032.</p><p><strong>Conclusion: </strong>The demand for vitreoretinal surgery in China has grown substantially over the last decade and is anticipated to rise further. Healthcare systems must adapt to accommodate the high demand.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2363-2371"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function.","authors":"Yuchen Li, Weida Xu, Guiyang Zhao, Yuchen Guo, Liyuan Wang, Qianming Du, Yuxiang Fei, Xueteng Hu, Haoshen Hu, Lixun Chen, Yidan Xu","doi":"10.2147/OPTH.S521660","DOIUrl":"10.2147/OPTH.S521660","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have demonstrated that mitochondrial dysfunction is pivotal in early diabetic retinopathy (DR). Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis.</p><p><strong>Methods: </strong>We established in vivo and in vitro models of DR. Hematoxylin and eosin (H&E) staining was utilized to evaluate retinal lesions in rats. Western blotting, reverse transcription quantitative polymerase chain reaction (RT-qPCR), and immunofluorescence staining were employed to assess TRAP1 expression in the retina. Cell viability, reactive oxygen species (ROS), mitochondrial damage, and TRAP1 expression levels were measured in ARPE-19 cells. RNA sequencing (RNA-seq) identified gene expression and pathway changes in shTRAP1 cells. The role of TRAP1 in ferroptosis in ARPE-19 cells was evaluated with or without ferrostatin-1 (Fer-1) and erastin. Potential ferroptosis-related proteins interacting with TRAP1 were validated using co-immunoprecipitation (CO-IP) techniques. This study confirmed TRAP1's critical role in the pathogenesis of DR.</p><p><strong>Results: </strong>Our findings elucidate a significant reduction in TRAP1 expression in diabetic rat retinas, particularly in the pigment epithelium. High glucose levels correspondingly diminished TRAP1 expression in ARPE-19 cells, causing decreased cellular viability, increased ROS generation, and mitochondrial dysfunction. Notably, the overexpression of TRAP1 effectively preserved mitochondrial homeostasis under stress, mitigated mitochondrial impairment, and enhanced cellular viability. Importantly, TRAP1 may alleviate hyperglycemia-induced mitochondrial damage by reducing ferroptosis through its interactions with ferroptosis-related proteins, including acyl-CoA synthetase long-chain family member 1 (ACSL1), acyl-CoA synthetase long-chain family member 4 (ACSL4), and cytochrome b5 reductase 1 (CYB5R1).</p><p><strong>Conclusion: </strong>TRAP1 exerts a protective influence on mitochondrial function in ARPE-19 cells. Reduced levels of TRAP1 may play a crucial role as an early contributor to mitochondrial dysfunction in diabetic retinopathy. Furthermore, the association of TRAP1 with ferroptosis improves cellular viability by enhancing mitochondrial resilience against high glucose-induced stressors and preventing cellular ferroptosis.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2343-2362"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposing a New Classification for Managing Prostaglandin-Induced Enophthalmos in Glaucoma Patients.","authors":"Vanessa Ferraro, Alessandro Gaeta, Gianmaria Barone, Filippo Confalonieri, Costanza Tredici, Paolo Vinciguerra, Alessandra Di Maria","doi":"10.2147/OPTH.S531288","DOIUrl":"10.2147/OPTH.S531288","url":null,"abstract":"<p><strong>Purpose: </strong>Glaucoma is commonly treated with prostaglandin analogs (PGAs), which effectively reduce intraocular pressure. However, PGAs can cause ocular side effects, including prostaglandin-associated periorbitopathy syndrome (PAPS), characterized by fat loss, enophthalmos and increased orbital structure prominence. The underlying mechanism is believed to involve adipocyte apoptosis, altered lipid metabolism, and changes in soft tissue dynamics. Currently, there is no standardized grading for enophthalmos, complicating its management. This study aimed to classify prostaglandin-induced enophthalmos and explore surgical or minimally invasive treatments, focusing on Italian Caucasian patients.</p><p><strong>Materials and methods: </strong>The study, conducted at IRCCS Humanitas Research Hospital between 2005 and 2023, assessed PAPS in primary open-angle glaucoma patients. It included a two-phase approach: (1) classification of enophthalmos using clinical and radiological measures to create a composite PAPS score; and (2) evaluation of treatment options, including Calcium Hydroxylapatite (CAHY) injections and autologous fat grafting.</p><p><strong>Results: </strong>A retrospective analysis of 120 glaucoma patients with prostaglandin-induced enophthalmos identified severity levels using the PAPS classification. The proposed therapeutic algorithm stratifies treatment: mild cases benefit from conservative management or fillers, moderate cases from calcium hydroxyapatite (CAHY) injections, and severe cases from combined CAHY and autologous fat grafting.</p><p><strong>Conclusion: </strong>A lack of a standardized grading system hinders consensus on management of PAPS. We propose a novel composite scoring system integrating six clinical parameters to stratify patients and tailor a minimally invasive therapeutic approach using calcium hydroxyapatite fillers and autologous fat grafting to restore orbital volume, improve eyelid aesthetics, and reduce complications. This classification system may serve as a clinical tool in patients with persistent or advanced PAPS who seek cosmetic correction or relief from functional symptoms.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2295-2303"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Stereoacuity Across Distances in Bilateral Intraocular Lens Implantation: Monofocal versus Diffractive Multifocal Lenses.","authors":"Tsutomu Ohashi, Akio Fujiya, Maiko Yoshida, Takashi Kojima","doi":"10.2147/OPTH.S527617","DOIUrl":"10.2147/OPTH.S527617","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate stereopsis at various distances after bilateral implantation of multifocal and monofocal intraocular lenses (IOLs).</p><p><strong>Patients and methods: </strong>This study included 173 patients who underwent cataract surgery, with 70 receiving bilateral multifocal and 103 receiving bilateral monofocal IOLs. Stereoacuity was assessed without correction in the multifocal group and with correction in the monofocal group at far, intermediate, and near distances. Age-matched comparisons were conducted as the mean age was low in the multifocal group. Stereoacuity was assessed at 0.3, 0.5, 0.7, 3, and 5 m using a Binoptometer 4P.</p><p><strong>Results: </strong>Stereoacuity was significantly better in the multifocal group than in the monofocal group at all distances (p < 0.05), except at 0.3 and 5 m after age matching. The proportion of patients achieving 100 arcsec or better was significantly higher in the multifocal group than in the multifocal group at all distances except 0.3 m (p < 0.05). Additionally, significant differences were noted only at 0.7 m after age matching (p < 0.05). The proportions of patients unable to identify 600 arcsec in the multifocal, monofocal, and age-matched monofocal groups were 3%, 11%, and 11% at 0.3 m; 0%, 9%, and 14% at 0.5 m; 0%, 9%, and 8% at 0.7 m; 0%, 5%, and 3% at 3 m; and 0%, 6%, and 6% at 5 m, respectively. After age matching, poor stereopsis was significantly reduced in the multifocal group at 0.5 m (p < 0.05) but not at 0.7 m.</p><p><strong>Conclusion: </strong>Patients with bilateral implanted multifocal IOLs exhibited superior stereopsis across various distances than those with bilateral monofocal IOLs. Additionally, fewer patients with multifocal IOLs experienced poor stereopsis. These results suggest that multifocal IOLs may help patients in maintaining stereopsis by facilitating focus on multiple points from far to near distances daily.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2325-2332"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-Analysis of Association Between Strabismus in Children/Adolescents and Risk of Mental Health Disorders.","authors":"Luksanaporn Krungkraipetch, Naruporn Krungkraipetch, Thanatporn Threetong","doi":"10.2147/OPTH.S530788","DOIUrl":"10.2147/OPTH.S530788","url":null,"abstract":"<p><strong>Background: </strong>Strabismus, or eye misalignment, is a common condition in children and adolescents. This meta-analysis examined the association between strabismus and mental health disorders including attention deficit hyperactivity disorder (ADHD), anxiety, depression. The strength and consistency of the relationships between strabismus and the risk of mental health disorders and how the associations vary according to characteristics including study size, temporal trends, and type of strabismus type were assessed.</p><p><strong>Methods: </strong>We conducted a meta-analysis with nine observational studies published between 2008 and 2024, involving 683,942 participants. The effect sizes were calculated as odds ratios (ORs) with 95% confidence intervals (CIs), and heterogeneity was assessed using the I² statistic to determine the associations between strabismus and mental health disorders.</p><p><strong>Results: </strong>The analyses revealed a significant positive association between strabismus and mental health disorders, with a weighted average OR of 1.92 (95% CI: 1.38-2.66; I² = 99.7%). Temporal trends suggested that earlier studies reported larger effect sizes, whereas more recent studies showed modest although significant associations. The strongest associations were observed in studies of exotropia; the ORs ranged from 1.44 to 2.70. The study sizes and precisions varied; larger studies provided more reliable estimates and smaller studies showed wider CIs.</p><p><strong>Conclusion: </strong>Strabismus was significantly associated with an increased risk of ADHD, anxiety, and depression. This association was consistent across different strabismus types and study designs. These findings underscore the importance of mental health screening in children and adolescents with strabismus, particularly those with exotropia. Further research should explore the mechanisms underlying this relationship and the effects of early intervention programs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2333-2342"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress in Dry Eye Disease: A Bibliometric Analysis.","authors":"Yifan Lei, Xin Yun Huang, Haodong Guo, Rongqing Huang, Yajun Shi, Jue Hong, Yanting Yang, Xiaopeng Ma","doi":"10.2147/OPTH.S532001","DOIUrl":"10.2147/OPTH.S532001","url":null,"abstract":"<p><strong>Purpose: </strong>To study the knowledge structure and evolution of oxidative stress in dry eye disease (DED) using bibliometrics and explore prospective anti-oxidative stress strategies for future clinical interventions.</p><p><strong>Methods: </strong>The Web of Science Core Collection (WoSCC) was used as the data source to systematically retrieve and screen the research literature published between January 1, 1992, and December 31, 2024, related to oxidative stress research in DED. The data were then analyzed using VOSviewer, CiteSpace, and R package Bibliometrix to visualize the network of countries, organizations, journals, authors, and keywords related to oxidative stress in DED.</p><p><strong>Results: </strong>A total of 491 publications were identified over a 30-year period from 1995 to 2024. There is a general upward trend in annual publications. The most prolific countries, institutions, journals and authors were China, KEIO UNIV, INVEST OPHTH VIS SCI, and TSUBOTA K, respectively. The keywords in this research field mainly focused on inflammation, ocular surface, antioxidants, lacrimal glands, cornea, reactive oxygen species. \"Ferroptosis\", \"nanoparticles\", \"diabetic retinopathy\", \"autophagy\", \"meibomian glands\", and \"NLRP3 inflammasome\" are emerging research hotspots in recent years.</p><p><strong>Conclusion: </strong>This study provides the first bibliometric approach to hot topics and emerging trends in the field of oxidative stress in DED. \"Ferroptosis\", \"nanoparticles\", \"autophagy\", \"NLRP3 inflammasome\", and so on are emerging directions being investigated in the field. Antioxidants in nanocarriers show promising applications. Clinical translation and international cooperation are the keys to future breakthroughs. Interdisciplinary collaboration should be strengthened to promote precision medicine and innovative therapy development.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2305-2324"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Intraocular Pressure in Cataract Surgery: A Comparative Consecutive Case Series Study.","authors":"Alexander Sarossy, Rahul Chakrabarti","doi":"10.2147/OPTH.S532483","DOIUrl":"10.2147/OPTH.S532483","url":null,"abstract":"","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2289-2294"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}