Tailored Anti-VEGF Therapy with New Generation Optimizations (TANGO) Treatment Regimen for Neovascular Age-Related Macular Degeneration: Rationale, Design, and Simulation Study.

Purpose: To present the rationale and design of the Tailored Anti-VEGF therapy with New Generation Optimizations (TANGO) treatment regimen for neovascular age-related macular degeneration and to simulate potential number of visits and injections with TANGO and compare to other treatment regimens.

Methods: This is a descriptive short report of the rationale and design of TANGO. The purpose of TANGO is to lessen the burden of therapy with new generation anti-VEGF medications that have better durability. We also simulate the potential number of visits and injections during the first year with TANGO and compare these numbers to other treatment regimens.

Results: Our report describes TANGO and provides a flow chart for its use. Our simulations suggest that TANGO may lead to a reduced number of visits and injections.

Conclusion: Our simulations suggest that employing TANGO may lead to a reduced number of visits and anti-VEGF injections while still providing intensive therapy for those who require it. However, it should be emphasized that this is a descriptive report and a simulation study, and clinical real-world studies of efficacy and safety using TANGO are warranted to better understand implications of employing TANGO in routine clinical practice.