Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Real-World Outcomes of Combined Phacoemulsification and STREAMLINE^® Canaloplasty: Interim Analysis of a Longitudinal Single-Center Retrospective Study.","authors":"Joseph Stanke, Don Nguyen","doi":"10.2147/OPTH.S508611","DOIUrl":"https://doi.org/10.2147/OPTH.S508611","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical outcomes of a novel ab interno minimally invasive procedure with the STREAMLINE^® Surgical System for creation of incisional goniotomies and canaloplasty in eyes with primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>In a retrospective analysis of all consecutive cases performed and followed for up to 12 months, 51 eyes of 51 subjects with mild, moderate, and severe primary open-angle glaucoma (POAG) underwent canaloplasty and incisional goniotomy following phacoemulsification cataract extraction. The procedure was performed according to the manufacturer's instructions for use. However, in contrast to other studies where the technique involved solely incisional goniotomy during viscoelastic delivery, in this study, a 1-2 clock hour goniotomy was created with the cannula after 3-6 injections of viscoelastic into Schlemm's canal. Outcomes in this interim analysis included mean reduction in IOP and medications through month 12, as well as the proportion of eyes achieving IOP reduction ≥20% from baseline.</p><p><strong>Results: </strong>Mean preoperative IOP was 16.9 mmHg using a mean of 1.2 medications (n = 51). At 30 days post-op, mean IOP was 15.3 mmHg using a mean of 0.2 medications; 21.6% (11/51) had IOP reduction ≥20% from baseline; 90.2% (46/51) were medication-free. At 6 months post-op, mean IOP was 15.6 mmHg using a mean of 0.2 medications; 21.6% (11/51) had IOP reduction ≥20% from baseline; 90.2% (46/51) were medication-free. At 12 months post-op, mean IOP was 17.0 mmHg using a mean of 0.2 medications, 37.3% (19/51) had IOP reduction ≥20% from baseline; 88.2% (45/51) were medication-free. No adverse events were reported. No secondary surgical interventions were required in any patient.</p><p><strong>Conclusion: </strong>Canaloplasty and incisional goniotomy combined with phacoemulsification safely and effectively reduced dependence on IOP-lowering medications while adequately managing IOP in eyes with primary open-angle glaucoma through 12 months of follow-up.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1331-1337"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proactive Post-Injection Monitoring in Brolucizumab Therapy: A Study on Intraocular Inflammation and Treatment Outcomes.","authors":"Manoj Soman, Apoorva Jadhav, Abhaya Balakrishnan, Jay U Sheth, Unnikrishnan Nair","doi":"10.2147/OPTH.S520118","DOIUrl":"https://doi.org/10.2147/OPTH.S520118","url":null,"abstract":"<p><strong>Purpose: </strong>Intravitreal anti-VEGF agents, such as Brolucizumab, play a crucial role in treating neovascular age-related macular degeneration (nAMD) and Polypoidal choroidal vasculopathy (PCV). While Brolucizumab offers advantages like extended duration and fewer injections, concerns about intraocular inflammation (IOI) have emerged. This study evaluates the outcomes of a proactive monitoring protocol for Brolucizumab-treated eyes with resistant nAMD and PCV.</p><p><strong>Patients and methods: </strong>A single-center retrospective study analyzed patients treated with Brolucizumab for resistant nAMD and PCV. Data on demographics, visual outcomes and IOI incidence, with the latter being confirmed by clinicians. Additional data on management strategies and follow-up adherence were also analyzed. Proactive monitoring included telephonic follow-up on day one and mandatory clinic visits on days 15 and 30. Retreatment followed a pro-re-nata (PRN) approach based on fluid persistence or visual acuity loss.</p><p><strong>Results: </strong>Between February 2022 and September 2024, 311 Brolucizumab injections were administered to 144 eyes of 121 patients, with a mean follow-up of 8.6 months. IOI occurred in 7 eyes (4.9%), with a mean onset of 32.1 days. According to the HAWK and HARRIER discomfort grading scale, IOI was categorized as mild in 2 eyes (28.6%), moderate in 3 eyes (42.9%), and severe in 2 eyes (28.6%). Symptoms varied, including blurred vision, floaters, redness, and ocular pain. Inflammation was managed with topical and oral steroids, with resolution in 6 weeks for vasculitis and 9 weeks for vitritis, and no cases required intravitreal agents or vitrectomy. Visual acuity improved or remained stable for most, except in one case of persistent vitritis.</p><p><strong>Conclusion: </strong>This study highlights the incidence of IOI with Brolucizumab in a real-world setting, emphasizing the importance of proactive monitoring and early intervention. Despite the occurrence of inflammation, visual outcomes were generally favorable, supporting the safety of Brolucizumab when managed carefully.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1313-1321"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Corneal Sensitivity Loss in Patients with and without Dry Eye Disease.","authors":"Matthew Stolz","doi":"10.2147/OPTH.S513005","DOIUrl":"https://doi.org/10.2147/OPTH.S513005","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the prevalence of corneal sensitivity loss in consecutive patients presenting to the clinic as well as in those patients with and without dry eye disease (DED).</p><p><strong>Methods: </strong>Retrospective, single-center study of consecutive patients who presented to the eye clinic and underwent corneal sensitivity testing using a non-contact esthesiometer. Data included demographics, medical history, prior or current treatments, comorbidities, corneal sensitivity measurements, dry eye symptoms (Standard Patient Evaluation of Eye Dryness Questionnaire [SPEED] questionnaire), and corneal staining scores (Oxford scale). The primary outcome was the prevalence of corneal sensitivity loss, defined as ≥8 mbar. Secondary outcome measures included the prevalence of corneal sensitivity loss in eyes with DED (Oxford ≥2 and SPEED ≥5) and without DED (Oxford ≤1 and SPEED <5).</p><p><strong>Results: </strong>A total of 395 eyes of 198 patients were included for analysis. Average age was 67.7 ± 16.0 years, and the majority of patients (60.6%) were female. Corneal sensitivity loss was observed in 9.4% of all eyes, and 12.6% of patients had reduced corneal sensitivity in at least one eye. When assessing eyes with signs of DED (Oxford ≥2), 19.7% (13/66) had corneal sensitivity loss. This prevalence increased to 31.4% (11/35) in eyes with both signs and symptoms of DED. Conversely, the prevalence was 5.5% (12/219) in eyes without DED. Binary logistic regression demonstrated that Oxford staining score was the strongest predictor of reduced corneal sensitivity (OR: 2.0, 95% CI: 1.3-3.0, p=0.001), with other significant factors including history of DED, stroke, and herpes zoster virus.</p><p><strong>Conclusion: </strong>Reduced corneal sensation, a sign of corneal nerve damage and precursor to neurotrophic keratitis, affects nearly 10% of all eyes and 30% of eyes with signs and symptoms of DED. Routine clinical testing of corneal sensation should be implemented, particularly in patients with DED, to ensure early diagnosis and prompt treatment to prevent disease progression.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1323-1330"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Surgical Outcome of Trabeculectomy with Mitomycin C: A Comparison Between Primary and Secondary Glaucoma in Thailand.","authors":"Ployroung Arampinyokul, Kulawan Rojananuangnit","doi":"10.2147/OPTH.S518659","DOIUrl":"https://doi.org/10.2147/OPTH.S518659","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the long-term surgical outcomes of trabeculectomy with mitomycin C (MMC) and identify factors associated with surgical failure in Thai patients with primary and secondary glaucoma.</p><p><strong>Methods: </strong>This retrospective study included 421 eyes from 397 patients with glaucoma who underwent trabeculectomy with MMC from January 1, 2012, to December 31, 2015. The patients' demographics, baseline characteristics, ocular parameters, and postoperative outcomes were analyzed. Surgical success was classified into complete success (IOP = 4-21 mmHg without anti-glaucoma medication), qualified success (IOP = 4-21 mmHg with medication), and failure (IOP >21 mmHg or <4 mmHg). Factors associated with surgical failure were assessed using Cox regression analysis.</p><p><strong>Results: </strong>The cumulative probability of complete or qualified success at 8 years was 65.9% (95% CI: 59.9%, 71.9%); however, a significantly higher success rate was observed in the primary glaucoma group (75.1%) than in the secondary glaucoma group (47.4%) (p < 0.001). The secondary glaucoma group, particularly those with secondary closed-angle glaucoma, had the lowest success rates. Preoperative IOP, number of anti-glaucoma medications, and visual acuity were significantly different between the two groups. Etiologic factors associated with surgical failure included pseudo-exfoliation glaucoma (adjusted HR 3.23), neovascular glaucoma (adjusted HR 2.87), and secondary angle closure glaucoma (adjusted HR 2.62). Late complications were more prevalent in patients with secondary glaucoma than in those with primary glaucoma and included decreased visual acuity (5.43% vs 10.29%), hypotony (0.26% vs 1.14%), corneal decompensation (1.82% vs 3.40%), and bleb-related infection (0.19%).</p><p><strong>Conclusion: </strong>Trabeculectomy with MMC remains an effective surgical option for primary glaucoma, demonstrating better long-term outcomes compared to its outcomes in patients with secondary glaucoma. Risk factors for surgical failure include specific glaucoma etiologies. These findings would personalize management strategies to optimize surgical approaches based on predictive factors for surgical success.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1299-1311"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Iridotomy-Less Approach in Descemet's Membrane Endothelial Keratoplasty Using Pupil-Dilating Eye Drops, a Retrospective Case-Control Study.","authors":"Tarek Bayyoud, Karl Ulrich Bartz-Schmidt, Martin Rohrbach, Faik Gelisken, David Goldblum, Peter Martus, Sebastian Thaler","doi":"10.2147/OPTH.S509682","DOIUrl":"https://doi.org/10.2147/OPTH.S509682","url":null,"abstract":"<p><strong>Purpose: </strong>To assess clinical outcomes after Descemet's Membrane Endothelial Keratoplasty (DMEK) with mydriatic eye drops without peripheral iridotomy (PI-less). We performed a retrospective, observational clinical study to determine the postoperative intraocular pressure (IOP) changes and graft viability in a cohort of patients with Fuchs' endothelial corneal dystrophy (FECD) and bullous keratopathy (BK).</p><p><strong>Patients and methods: </strong>Included in this study were 41 PI-less DMEK patients with 44 eyes (median age: 77 years; range: 53-88 years). Patients received either PI-less DMEK (group-1) or PI-less triple DMEK (group-2). The mean follow-up duration was 16 months. Eyes after standard DMEK or triple DMEK served as controls (n = 20). Included in the study were patients admitted to the hospital (securing IOP control), patients in which the tamponading agent was air or gas (SF6) and only patients with physiological air resorption, ie without routine, postoperative air/gas release (90% air/gas fill of the anterior chamber at end of surgery). Phakic eyes were not included. Postoperatively, mydriatic eye drops were administered for three days 4x/d (phenylephrine 25 mg/mL, tropicamide 5 mg/mL). The best-corrected visual acuity (BCVA), endothelial cell density (ECD), and IOP were assessed. Intra- and postoperative complications and management were recorded.</p><p><strong>Results: </strong>BCVA improved significantly in both groups (group-1:0.90 ± 0.57 to 0.20 ± 0.23logMAR (p = 0.000); group-2:0.47 ± 0.23 to 0.17 ± 0.42logMAR (p = 0.0067). ECD decreased significantly: Group-1 2428±225 cells/mm² to 1810±236 cells/mm² (p = 0.005); group-2 2447 ± 178 cells/mm² to 1866 ± 229 cells/mm² (p = 0.012). After postoperative day-1 IOP decreased significantly: Group-1 p = 0.004 (10.0 ± 2.8 mmHg) and p = 0.002 (11.3 ± 3.1 mmHg); group-2 p = 0.002 (10.7 ± 3.6 mmHg) and p = 0.002 (11.4 ± 2.2 mmHg); for postoperative days 2 and 3, respectively. Postoperative adverse events included pupillary block necessitating emergency air release. Intergroup analysis did not show a significant difference in ECD, IOP (after postoperative day-1) and logMAR (after 6 months).</p><p><strong>Conclusion: </strong>Patients may benefit from the promising results of the study regarding postoperative IOP developments and graft viability after DMEK using mydriatic eye drops (phenylephrine 25 mg/mL, tropicamide 5 mg/mL). PI-less triple DMEK in particular might improve accessibility, reduce surgical complexity, or lower costs, making it attractive in resource-limited settings. Close postoperative IOP monitoring is advised in PI-less DMEKs.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1277-1288"},"PeriodicalIF":0.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Online Visual Acuity Testing with Dynamic Dyop and Static LogMAR Optotypes in Healthy Non-Presbyopic and Presbyopic Individuals.","authors":"Reut Ifrah, Dinah Paritzky","doi":"10.2147/OPTH.S519947","DOIUrl":"https://doi.org/10.2147/OPTH.S519947","url":null,"abstract":"<p><strong>Introduction: </strong>Visual acuity (VA) is typically measured using stationary optotypes, though real-world visual experiences involve dynamic targets. The Dyop (dynamic optotype) VA test is a computerized motion perception assessment designed to simulate daily visual experiences. With the rise of telemedicine, this study examined the feasibility and agreement between virtual online VA testing using Dyop compared to standard LogMAR optotypes in non-presbyopic and presbyopic participants.</p><p><strong>Methods: </strong>After an initial online Zoom^® meeting verifying inclusion criteria and technical feasibility, participants accessed the examiner's computer using the \"Anydesk\" application enabling them to view the \"Chart 2020\" program. Monocular right eye VA was measured three consecutive times using Dyop and LogMAR optotypes in a counter-balanced design. Participants aged 18-39 yrs were considered non-presbyopic, and those 40-60 yrs were considered presbyopic. VA measurements were analyzed using the Mann-Whitney <i>U</i>-test, Spearman correlation coefficients, intraclass correlation coefficients (ICC), and non-parametric Bland-Altman analysis, which examined median differences and limits of agreement (LoA).</p><p><strong>Results: </strong>Of the 110 participants, (70% females, mean age: 32.5 ± 13.0, range: 18-60), 73 (66%) were considered non-presbyopic (mean age: 24.1 ± 4.9, range: 18-39), and 37 (34%) were presbyopic (mean age: 49.0 ± 6.4, range: 40-60). The mean VA measured with the Dyop and LogMAR charts for the entire cohort (0.09 and 0.08), for the non-presbyopic (0.09 and 0.07) and the presbyopic (0.10 and 0.09) sub-groups was significantly positively correlated (r = 0.80, p < 0.001, r = 0.82, p < 0.001 and r = 0.72, p < 0.001, respectively), with a small mean difference (-0.01 ± 0.08, -0.02 ± 0.08, -0.01 ± 0.09 log units), for the entire cohort, the non-presbyopic, and the presbyopic, respectively. There were no significant differences between the two tests for the whole cohort (p = 0.80), for group 1 (p = 0.98) and for group 2 (p = 0.62).</p><p><strong>Conclusion: </strong>This study demonstrated the feasibility of online VA measurements and that online VA measurements using Dyop and LogMAR optotypes are interchangeable in healthy non-presbyopic and presbyopic participants.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1289-1297"},"PeriodicalIF":0.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma Home Monitoring Using Online Circular Contrast Perimetry Over 6 Months: Performance and Patient Attitudes in the Developing World Setting.","authors":"Tung Thanh Hoang, Tung Quoc Mai, Dung Thi Pham, Xuan Thi Nguyen, Duc-Anh Nguyen, Diu Thi Vu, Hien Thi Hoang, Simon Edward Skalicky","doi":"10.2147/OPTH.S519093","DOIUrl":"https://doi.org/10.2147/OPTH.S519093","url":null,"abstract":"<p><strong>Purpose: </strong>Online circular contrast perimetry (OCCP) provides perimetry on any computer or tablet without additional hardware. This study assessed the longitudinal performance and user feedback of home OCCP in an Asian population.</p><p><strong>Methods: </strong>Twenty glaucoma and fifteen healthy participants underwent a comprehensive ocular examination and visual field tests in clinic, using OCCP and standard automated perimetry. Within a week, participants were asked to repeat OCCP at home. OCCP was then repeated after 3 months and 6 months at home, followed by a user-experience survey.</p><p><strong>Results: </strong>No significant difference between clinic and home OCCP for test duration, false negative (FN) and fixation loss (FL) rates was found. False positive (FP) rate of home OCCP was slightly higher than that of clinic OCCP (p = 0.04). Bland-Altman plots indicated a small difference between Mean Deviation (MD) (1.26 dB, p = 0.0087) and good agreements between Pattern Standard Deviation (PSD) and Visual Index (VI) of clinic OCCP and home OCCP with insignificant difference of PSD and VI (p > 0.05). Intraclass correlation coefficient (ICC) analysis demonstrated good correlation of MD & VI and poor correlation of PSD between clinic OCCP and home OCCP. Over 6 months, home OCCP indicated moderate to excellent correlation of indices. Participants reported a positive attitude toward home OCCP; however, a high dropout rate was noted for the 3- and 6-month at-home testing.</p><p><strong>Conclusion: </strong>Comparable results were observed between clinic and home OCCP at baseline. Acceptable consistency of home OCCP findings over 6 months was recognized. Patients may require additional support to achieve desired adherence to at-home monitoring protocols.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1263-1276"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Air Temperature and Pollution on Admissions for Acute Ophthalmic Inflammation at the Emergency Eye Department in Katowice, Poland, from 2011 to 2023.","authors":"Monika Sarnat-Kucharczyk, Dorota Wyględowska-Promieńska, Sudi Patel","doi":"10.2147/OPTH.S515938","DOIUrl":"https://doi.org/10.2147/OPTH.S515938","url":null,"abstract":"<p><strong>Purpose: </strong>To determine if significant correlations occur between recorded values for a) annual temperature, b) air pollution levels, and the prevalence of acute ophthalmic inflammation among patients attending an eye emergency department in an urban setting between 2011 and 2023.</p><p><strong>Patients and methods: </strong>A data bank of cases that attended an eye emergency unit (Medical University of Silesia, Katowice, Poland) between 1/1/2011 and 31/12/2023 was accessed. Cases were classified into inflammatory or noninflammatory ophthalmic groups. The former were then subdivided into subgroups for blepharitis, orbital inflammation, lacrimal system inflammation, conjunctivitis, scleritis, keratitis, uveitis with retinitis, endophthalmitis, and optic neuritis. Data on local temperatures and air pollution levels were obtained from available official publications.</p><p><strong>Results: </strong>Reporting key results (p < 0.05).Total attending the emergency unit increased from 8,172 to 14,261 (8854 during pandemic lockdown in 2020), prevalence of all acute ophthalmic inflammation (y) decreased from 64.70% to 55.40% and prevalence of conjunctivitis within this group decreased from 53.96% to 36.23%.Annual average (±SD) temperature (x, °C) in Silesia increased from 8.33°C (±9.18°) in 2010 to 10.64°C (±6.83°C) in 2020 (paired <i>t</i>-test, p = 0.04). Curvi-linear regression revealed, y = 1.915x³-55.624x²+534.09x-1631.2, (n = 10, r²= 0.489).Prevalence of conjunctivitis was directly correlated with atmospheric concentrations of sulphur dioxide, carbon monoxide and particulate matter in suspended dust with a diameter≤10 microns.After factoring all cases of conjunctivitis, a) prevalence of endophthalmitis, uveitis with retinitis, and scleritis were negatively correlated with temperature, b) atmospheric concentrations of certain pollutants were positively correlated with the prevalence of endophthalmitis, uveitis with retinitis, scleritis and keratitis; and negatively correlated with the prevalence of orbital and lacrimal inflammation, blepharitis, and optic neuritis.</p><p><strong>Conclusion: </strong>Air pollutants and temperature are linked to the prevalence of certain acute ophthalmic inflammations. Some correlations are negative suggesting some protection against the development of certain conditions. However, negative correlational effects do not necessarily imply negative causal effects.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1247-1261"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Corneal Parameters in Eyes With Chronic Ocular Hypotony and in Non-Hypotonic Eyes. Self-Controlled Case Series Study.","authors":"Rachid Bouchikh-El Jarroudi, Kolbe Roche Fernández, Pau Romera Romero, Tatiana Croitoru-Croitoru, Anna Goñi-Guarro, Jessica Botella-Garcia, Antoni Sabala Llopart, Jordi Loscos-Arenas, Sebastian Videla","doi":"10.2147/OPTH.S508165","DOIUrl":"https://doi.org/10.2147/OPTH.S508165","url":null,"abstract":"<p><strong>Introduction: </strong>There are no available data concerning corneal parameters in patients with chronic ocular hypotony. Our purpose is to provide evidence and clinical correlation on the biomechanical corneal changes in chronic hypotonic eyes.</p><p><strong>Patients and methods: </strong>A single-center, transversal, self-controlled case series study was conducted involving patients with at least one chronic hypotonic eye (defined as an intraocular pressure ≤6.5 mmHg measured on three separate occasions for at least three months). The chronic hypotonic eye was the case and the contralateral eye the control (non-hypotonic eye). We collected data from baseline characteristic and intraocular pressure (mmHg). Biomechanical corneal parameters measured by Corvis ST: deformation amplitude ratio (mm), Ambrósio's relational thickness (μm), stiffness parameter at first applanation (mmHg/mm), Integrated radius (mm^-1), stress-strain index, pachymetry (μm), and in addition macular folds were recorded as well. A descriptive and exploratory analysis was performed.</p><p><strong>Results: </strong>Between November 2021 and July 2023, a total of 16 consecutive patients (7 men, 9 women; age [median (range)]: 72 (62-84)), diagnosed with chronic ocular hypotony in one eye were included: 16 chronic hypotonic eyes and 16 non-hypotonic eyes. Hypotonic versus non-hypotonic eyes [median (range)]: intraocular pressure: 4 (2-6) mmHg, 16 (8-38) mmHg; deformation amplitude ratio: 5.6 (4.3-6.6) mm, 4.7 (3.9-5.5) mm, p-value= 0.002; Ambrósio's relational thickness: 482 (263-932) μm, 530 (210-818) μm, p-value: 0.845; stiffness parameter at first applanation: 61.5 (39-100) mmHg/mm, 113 (68-130) mmHg/mm, p-value: <0.001; Integrated radius: 10.9 mm^-1 (6.3-16.8), 7.9 mm^-1 (6.4-10.5), p-value: <0.001; stress-strain index: 0.7 (-0.2-4.9), 1.1 (-2.7-5.6), p-value: 0.034; pachymetry 509 (456-617) μm, 512 (436-775) μm, p-value: 0.637; and macular folds: 7/16, 0/16, p-value: <0.001.</p><p><strong>Conclusions: </strong>Chronic hypotonic eyes (eyes with a low intraocular pressure) present biomechanical corneal changes with respect to non-hypotonic eyes, mainly in deformation amplitude ratio, stiffness parameter at first applanation, stress-strain index and Ambrósio's relational thickness parameters. These biomechanical corneal changes could reflect softer, more elastic and deformable scleras, which at its turn can bear higher risk of hypotony maculopathy.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1237-1246"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Satisfaction with a Novel Daily Toric Contact Lens in Individuals with Previous Lens Failures.","authors":"Mylan T Nguyen, Melissa H Wright, Brad Hall, Phillip B Brunson","doi":"10.2147/OPTH.S510740","DOIUrl":"https://doi.org/10.2147/OPTH.S510740","url":null,"abstract":"<p><strong>Purpose: </strong>The primary purpose of this study is to assess the comfort and vision of Dailies Total1^® for Astigmatism contact lenses in subjects dissatisfied with their previously worn toric contact lenses.</p><p><strong>Patients and methods: </strong>In this prospective, non-comparative study, subjects aged 18 to 39 years with a history of unsuccessful previous astigmatism contact lens wear were recruited. Subjects were allocated and fitted with varying astigmatism powers of the Dailies Total1^® for Astigmatism contact lenses. After 30 days of wear, participants responded to a questionnaire consisting of a visual analog scale assessing overall comfort and vision and a Likert scale assessing comfort and vision throughout the day, at the end of the day (EOD), and as it pertains to real-world tasks.</p><p><strong>Results: </strong>Sixty-five subjects (130 eyes) completed the study, of which 50 were female, and 15 were male, with a mean (± standard deviation) age of 29.5 ± 5 years. Overall, 87.69% of the subjects reported a positive rating for comfort and 92.31% for satisfaction with vision. 78% of respondents reported positive ratings for comfort throughout the day and 55% at the end of the day. Comfort while working on the computer and utilizing a cellphone was rated at 80% and 86%, respectively. 85% either agreed or strongly agreed that the lenses provided clear vision throughout the day, and 71% at the end of the day. Positive ratings for vision while on the computer and while using a cellphone were 87% and 91%, respectively. Of all participants, based on comfort and vision, 58% favored continuing to wear the lenses after the study.</p><p><strong>Conclusion: </strong>The results suggest that Dailies Total1^® for Astigmatism contact lenses offer favorable comfort and vision for individuals who had previously been dissatisfied with their toric lenses.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"1229-1236"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11988191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}