Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Visual Outcomes and Prognostic Factors in Epiretinal Membrane Foveoschisis and Lamellar Macular Hole Surgery: A Retrospective Study.","authors":"Jan-Olof Carlsson, Anders Wirén, Maria Dukay, Koteiba Mageed, Sven Crafoord","doi":"10.2147/OPTH.S532123","DOIUrl":"10.2147/OPTH.S532123","url":null,"abstract":"<p><strong>Purpose: </strong>To assess vision outcomes, risk of complications and whether age, gender, specific OCT changes and preoperative vision affect the prognosis for postoperative vision development. We seek to clarify the prognosis of LMH after surgery and assess whether complications can be reduced with appropriate management.</p><p><strong>Methods: </strong>This retrospective study includes consecutive Lamellar Macular Hole (LMH) surgeries at Örebro University Hospital (2013-2019), re-evaluated using the OCT-based consensus definition. Cases were classified as Epiretinal Membrane Foveoschisis (ERM-F) or LMH. Pre- and postoperative data were collected from medical records. Statistical analyses were performed with support from medical statisticians.</p><p><strong>Results: </strong>Both the ERM-F and LMH groups showed Highly significant visual development (p-adj = 0.0010 and 0.0012 respectively), with a median visual improvement of 90% and 38%, respectively.Even the older LMH group, in which the majority (81%) exhibited pathological OCT findings, showed a median improvement of 61% and a significant visual improvement (adjusted p = 0.026).</p><p><strong>Conclusion: </strong>The results indicate good potential for visual improvement in both groups. Even if the LMH group experiences positive vision improvement, these patients would experience further improvement without the aforementioned OCT changes. Early surgery is highly recommended, ideally before photoreceptor damage occurs; if already present, it should be performed as soon as possible to prevent further OCT pathology.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3133-3144"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Validation of MOPTIM MRT-200 Refraction Device with 2WIN and Retinomax.","authors":"Heidi Schumacher, Giancarlo Garaygay, Aana Ayagalria, Bryant Ikaika Lauano, Denise M Marshall, J Richard Townley, Robert W Arnold","doi":"10.2147/OPTH.S545397","DOIUrl":"10.2147/OPTH.S545397","url":null,"abstract":"<p><strong>Background: </strong>Portable sphero-cylinder refraction is useful for remote medical missions and self-checking. A novel, inexpensive, handheld optical scope with an internal vision chart and adjustable diopter lens, called the Moptim MRT-200, was therefore validated.</p><p><strong>Methods: </strong>Young, capable patients from a pediatric eye practice had dry refraction estimates with the Moptim MRT-200, Adaptica 2WIN photoscreener, and Monocular Retinomax compared with actual refined retinoscopy. Vector-converted sphero-cylinder refractions and the univariate ABCD Ellipsoid were used for comparison as well as monocular visual acuity.</p><p><strong>Results: </strong>206 racially diverse, high-risk refractive patients with median \"Ellipsoid-Gap\" of 3.5 had high correlation spherical equivalent and similar ABCD Ellipsoid comparing Moptim MRT-200, 2WIN and Retinomax (Kruskal Wallis X²(5) = 4.2, p = 0.52) however the 61 patients with blur associated with Ellipsoid gap over 5.0 had better refractive accuracy with 2WIN and Retinomax than Moptim MRT-200 (p < 0.001). Visual acuity with Moptim MRT-200 had a weak correlation (ICC.41 AND.47) and a Bland-Altman mean difference of approximately 1 logMAR line less fine than the actual phoropter refraction.</p><p><strong>Conclusion: </strong>Precise sphero-cylinder estimation with the Moptim MRT-200 was too complex for lay screeners and many young patients, especially compared to 2WIN and Retinomax; however, rapid estimation of spherical refraction was feasible and valid.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3153-3166"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes Using a Trifocal Intraocular Lens in Eyes After Previous Laser Corneal Refractive Surgery or Radial Keratotomy: 1-Year of Follow-Up.","authors":"Jérôme C Vryghem, Achraf Laouani, Madjid Mansouri","doi":"10.2147/OPTH.S538552","DOIUrl":"10.2147/OPTH.S538552","url":null,"abstract":"<p><strong>Purpose: </strong>To show the clinical outcomes after implantation of a diffractive trifocal intraocular lens (IOL) in eyes with previous laser-corneal-refractive-surgery (LCRS) or radial keratotomy (RK).</p><p><strong>Methods: </strong>Eyes with previous LCRS (LASIK/PRK group) or RK (RK group) implanted with a diffractive trifocal IOL were enrolled in this retrospective study. Refraction and monocular Snellen decimal uncorrected-distance visual acuity (UDVA), corrected-distance visual acuity (CDVA), and uncorrected-near visual acuity (UNVA) were analyzed at 1-year.</p><p><strong>Results: </strong>The current study comprises 124 eyes: 102 eyes for the LASIK/PRK group and 22 eyes for the RK group. In the LASIK/PRK group 92.16% of eyes were within ±0.50D and 99.02% within ±1.00D (mean spherical equivalent of -0.03±0.30D). 91.18% of eyes showed 0.50D or less astigmatism, and all of them 1.00D or less (mean refractive cylinder of -0.21±0.27D). In the RK group, 81.82% eyes were within ±0.50D and 100% within ±1.00D, with a mean SE of -0.17±0.38D. 68.18% eyes showed 0.50D or less residual astigmatism, and 95.45% eyes 1.00D or less, with a mean cylinder of -0.45±0.39D. The mean UDVA, CDVA and UNVA were 1.04±0.19, 1.14±0.20 and 0.99±0.04, respectively, for the LASIK/PRK group, and 0.90±0.10, 1.01±0.08 and 1.00±0.00, respectively, for the RK group. For the LASIK/PRK group 72.55%, 88.24% and 98.04% of eyes had 20/20 or better UDVA, CDVA and UNVA, respectively, with 96.08%, 100% and 98.04% of eyes achieving 20/25 or better for UDVA, CDVA and UNVA, respectively. For the RK group, the percentages changed to 45.55%, 83.36%, 100%, 90.91%, 100% and 100%, respectively.</p><p><strong>Conclusion: </strong>The use of a diffractive trifocal IOL can provide good clinical outcomes in eyes with previous LCRS or RK.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3089-3102"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Diagnostic Capabilities of ChatGPT-4 Omni in Grading Diabetic Retinopathy Fundoscopy Using Color Fundus Photographs.","authors":"Nitin Chetla, Sai S Samayamanthula, Joseph He Chang, Arnold Y Leigh, Sinan Akosman, Mihir Tandon, Tamer R Hage, Michael Cusick","doi":"10.2147/OPTH.S517238","DOIUrl":"10.2147/OPTH.S517238","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults. Despite the importance of early DR detection, only 60% of patients with diabetes receive recommended annual screenings due to limited eye care provider capacity. FDA-approved AI systems were developed to meet the growing demand for DR screening; however, high costs and specialized equipment limit accessibility. More accessible and equally as accurate AI systems need to be evaluated to combat this disparity. This study evaluated the diagnostic accuracy of ChatGPT-4 Omni (GPT-4o) in classifying DR from color fundus photographs (CFPs) to assess its potential as a low-cost alternative screening tool.</p><p><strong>Methods: </strong>We utilized the publicly available EyePACS DR detection competition dataset from Kaggle, which includes 2,500 CFPs representing no DR, mild DR, moderate DR, severe DR, and proliferative DR. Each image was presented to GPT-4o with 1 of 8 prompts designed to enhance the model's accuracy. The results were analyzed through confusion matrices, and metrics such as accuracy, precision, sensitivity, specificity, and F1 scores were calculated to evaluate performance.</p><p><strong>Results: </strong>In prompts 1-3, GPT-4o showed a strong bias towards classifying images as no DR, with an average accuracy of 51.0%, while accuracy for other stages ranged from 70% to 80%. GPT-4o struggled with misclassifications, particularly between adjacent DR levels. It performed best in detecting proliferative DR (Level 4), achieving an F1 score above 0.3 and accuracy exceeding 80%. In binary classification tasks (Prompts 4.1-4.4), GPT-4o's performance improved, though it still had difficulty distinguishing mild DR (49.8% accuracy). When compared to FDA-approved AI systems, GPT-4o's sensitivity (47.7%) and specificity (73.8%) were significantly lower.</p><p><strong>Conclusion: </strong>While GPT-4o shows promise identifying severe DR, limitations in distinguishing early stages exist and highlight the need for further refinement before clinical usage in DR screening. Unlike traditional CNN-based tools like IDx-DR, GPT-4o is a multimodal foundation model with a fundamentally different architecture and training process, which may contribute to its diagnostic limitations. GPT-4o and other LLMs are not designed to learn about important DR features like microaneurysms or hemorrhages using pixel data which is why they may struggle to detect DR compared to CNN models.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3103-3112"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Burden Among Patients Receiving Anti-VEGF Intravitreal Injections for AMD and DR: A Cross-Sectional Study in Guangzhou.","authors":"Tingting Lin, Shuang Luo, Chufen Zhuang, Huiming Xiao, Xiaoyan Ding, Shuiling Li","doi":"10.2147/OPTH.S533237","DOIUrl":"10.2147/OPTH.S533237","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the caregiver burden and its associated factors among patients receiving anti-VEGF intravitreal injections for age-related macular degeneration (AMD) and diabetic retinopathy (DR) in a tertiary hospital in Guangzhou, China.</p><p><strong>Methods: </strong>This cross-sectional study recruited 88 patients who received intravitreal anti-VEGF injections and their primary caregivers. Patients completed the Activities of Daily Living (ADL) scale, while caregivers completed the Zarit Burden Interview (ZBI) and the Connor-Davidson Resilience Scale (CD-RISC). One-way ANOVA and Pearson correlation analysis were conducted to assess the associations between patient function, caregiver burden, and related sociodemographic factors.</p><p><strong>Results: </strong>The mean ADL score of patients was 18.99 ± 8.34, while the mean caregiver burden score was 18.22 ± 18.04. A significant positive correlation was found between the patient's ADL score and caregiver burden (r = 0.405, p < 0.01). Caregivers who were employed part-time or not cohabiting with patients reported significantly higher burden scores (p = 0.034 and p = 0.03, respectively). Additionally, the caregiver burden among DR patients was higher than among AMD patients (p = 0.026).</p><p><strong>Conclusion: </strong>Significant caregiver burden exists among those assisting patients receiving intravitreal injections, especially for DR patients and those with reduced ADL function. Caregiver availability and living arrangements should be considered in the design of follow-up schedules to improve treatment adherence and outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3071-3078"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Nerve Head Structural Changes After Intravitreal Injection.","authors":"Dania A Rahal, Darrin A McFall, Muhammad Z Chauhan, Ahmad M Mansour, Abdelrahman M Elhusseiny, Sami H Uwaydat","doi":"10.2147/OPTH.S544105","DOIUrl":"10.2147/OPTH.S544105","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the acute anatomical changes of Bruch's membrane opening (BMO) and optic nerve head (ONH) pit depth in patients receiving 0.05cc of anti-VEGF intravitreal injections (IVIs).</p><p><strong>Methods: </strong>We prospectively enrolled patients receiving IVIs and collected data including age, sex, race, phakic status, presence or absence of glaucoma, injection agent utilized, axial length, and cup-to-disc ratio (C/D). High-resolution spectral domain OCT imaging and measurements were made pre- and within five minutes post-IVI.</p><p><strong>Results: </strong>Fifty-one eyes of 51 patients were included in the study. 35.29% of patients were male. The mean age at the time of IVI was 78.27 ± 11.17 years. The average change in the pit depth after IVI was 31.57 ± 24.36 μm (p < 0.001). The number of IVIs previously received significantly correlated with a decreased change in pit depth post-injection (r = -0.369, p = 0.004). No significant relationship was identified between categorical or continuous variables and the change in pit depth or BMO after IVI. No significant associations were identified between the magnitude of IOP elevation and the change in pit depth post-IVI (r = 0.03, p = 0.834) or the number of previous IVIs (r = 0.005, p = 0.973).</p><p><strong>Conclusion: </strong>IVI was associated with a modest increase in ONH pit depth. The number of prior injections inversely correlated with this change, suggesting a potential cumulative effect on structural response. Given the link between ONH biomechanics and retinal nerve fiber layer (RNFL) thinning, our findings raise the possibility that repeated IVIs may contribute to structural changes relevant to glaucomatous progression.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3079-3087"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Behavioral Factors with Activation in Patients with Age-Related Macular Degeneration or Diabetic Retinopathy.","authors":"Alan R Morse, Lisa A Hark, William H Seiple, Prakash Gorroochurn, Haotian Tang, Rebecca Rojas, Royce Chen, Jason D Horowitz, Srilaxmi Bearelly, Vlad Diaconita, Aakriti Garg Shukla, Yujia Wang, Stefania C Maruri, Desiree R Torres, George A Cioffi, Stanley Chang, Tongalp Tezel","doi":"10.2147/OPTH.S542352","DOIUrl":"10.2147/OPTH.S542352","url":null,"abstract":"<p><strong>Introduction: </strong>Activation is the degree that individuals have the knowledge, skills, beliefs, and behaviors necessary for effective health-care self-management. Those with higher activation are more likely to engage in behaviors associated with improved care outcomes, including increased medication and appointment adherence. Identifying and addressing patients' activation levels and associated behaviors at the outset of care can help to develop interventions to improve patients' participation in their healthcare. Our objective was to study the association of psychosocial factors with activation to identify behavioral factors that could increase activation.</p><p><strong>Methods: </strong>Individuals with bilateral AMD or DR (n = 1146) were identified from electronic medical records at a single academic medical center. Randomly selected potential participants (n = 682) were sent a letter inviting their participation. Consenting participants (AMD n = 161; DR n = 94) were administered the Patient Activation Measure (PAM), the National Eye Institute Visual Function Questionnaire-8 (NEI-VFQ), Multidimensional Health Locus of Control - form C (MHLC), Perceived Medical Condition Self-Management Scale (PMCSMS), Patient Health Questionnaire-9 (PHQ-9), a measure of health literacy and a sociodemographic health questionnaire by phone.</p><p><strong>Results: </strong>In multivariable analysis of participants with AMD, for each unit increase in MHLC Internal score, mean PAM score increased by 0.50 (P = 0.001). In multivariable analysis of participants with DR, for each unit increase in MHLC Chance, mean PAM score decreased by 0.48 (P = 0.0391). Differences on MHLC Internal and Chance scores among and between those with dry or wet AMD and non-proliferative or proliferative DR were all significant (P < 0.001).</p><p><strong>Discussion: </strong>In this cross-sectional cohort study of 255 participants with bilateral diabetic retinopathy or age-related macular degeneration, higher internal LOC and lower external LOC were associated with higher activation scores. Interventions that increase patient activation may increase internal LOC and reduce external LOC, improving patients' participation in their care, and improve health-care outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3059-3069"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Evaluation of Lifitegrast Ophthalmic Solution 5% in Symptomatic Contact Lens Wearers.","authors":"Marc-Matthias Schulze, Sarah E Guthrie, Brandon Ho, Jill Woods, Lyndon Jones","doi":"10.2147/OPTH.S538184","DOIUrl":"10.2147/OPTH.S538184","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of lifitegrast ophthalmic solution 5% in alleviating end-of-day dryness and discomfort in symptomatic contact lens (CL) wearers.</p><p><strong>Patients and methods: </strong>This was an open-label study in symptomatic CL wearers with ratings of ≥40 for end-of-day dryness on a visual analog scale (VAS; 0-100 scale; 100 worst). Participants wore their habitual CLs and instilled lifitegrast twice daily for 12 weeks with lenses removed. The performance of lifitegrast was assessed by comparing VAS 0-100 ratings (100=worst) at 2, 6 and 12 weeks for end-of-day dryness and discomfort and Contact Lens Dry Eye Questionnaire-8 (CEQ-8) scores to baseline levels. Tear samples were collected at all visits to measure 10 different tear cytokines.</p><p><strong>Results: </strong>Forty participants (33F, mean age 30.8±12.1 years, 65% daily disposable CL users) completed the study. There were no serious adverse events. Median (range) visual analog scale ratings for end-of-day dryness (Baseline: 76 (19-99); 2-weeks: 43 (0-95); 6-weeks: 26 (0-94); 12-weeks: 15 (0-98)) and discomfort (Baseline: 70 (10-97); 2-weeks: 45 (0-95); 6-weeks: 25 (0-84); 12-weeks 11 (0-96)) both significantly improved over time (all p<0.01). At baseline, 100% of participants rated dryness ≥40, which dropped to 17% at 12 weeks. Baseline CLDEQ-8 scores of 22 (12-31) had significantly decreased to 11 (1-26) at 12 weeks. Comfortable CL wear time increased significantly from 6±2 hours at baseline to 9±3 hours at 6 and 12 weeks (all p<0.01). Cytokine levels did not change over time.</p><p><strong>Conclusion: </strong>Lifitegrast significantly improved end-of-day dryness, end-of-day discomfort, CLDEQ-8 scores and comfortable CL wear time within 2 weeks of use.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3033-3049"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Year Real-World Outcomes of Faricimab for Diabetic Macular Edema in Japan.","authors":"Yuki Mizuki, Soichiro Inokuchi, Tsubasa Kuroki, Akihiro Kamata, Junji Onishi, Yoshiko Watanabe, Masato Takeda, Akira Meguro, Tatsukata Kawagoe, Takeshi Teshigawara, Norihiro Yamada, Nobuhisa Mizuki","doi":"10.2147/OPTH.S547179","DOIUrl":"10.2147/OPTH.S547179","url":null,"abstract":"<p><strong>Background: </strong>Diabetic macular edema (DME) is a leading cause of vision loss in working-age adults. Faricimab, a bispecific antibody targeting VEGF and Ang-2, has been shown to reduce treatment burden by enabling extended injection intervals. However, real-world, long-term data from Japanese populations are limited.</p><p><strong>Purpose: </strong>To evaluate the two-year efficacy and safety of intravitreal faricimab for DME in a real-world clinical setting in Japan.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at the International Goodwill Hospital, Yokohama, Japan. Patients with DME who were followed for two years after initiating intravitreal faricimab. Outcome measures included central subfield thickness (CST), best-corrected visual acuity (BCVA), macular fluid resolution, and recurrence. Changes were evaluated using nonparametric tests and survival analysis.</p><p><strong>Results: </strong>We analyzed 9 patients (16 eyes) with DME who were followed for two years after initiating intravitreal faricimab. A four-injection loading phase was omitted in all but one case, with a median of one initial injection. CST decreased from 332.3 µm to 267.0 µm (p = 0.069), and BCVA remained stable (0.49 to 0.55 logMAR, p = 0.2081). Complete macular fluid resolution occurred in 87.5% of eyes, with a median resolution time of 6 months. Recurrence occurred in 37.5% of eyes during follow-up, with a median time to recurrence of 9 months. Among eyes on fixed dosing (n = 11), 72.7% achieved a final injection interval of ≥12 weeks. Intraretinal fluid (IRF) significantly decreased (p = 0.0078), and chronic cystoid changes were associated with limited CST reduction (p = 0.016). No treatment-related adverse events were reported.</p><p><strong>Conclusion: </strong>Faricimab demonstrated favorable anatomical outcomes and extended injection intervals over two years in a real-world setting, despite the omission of a loading phase in most cases. These findings support its practical utility of faricimab for DME management in Japan.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3051-3058"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational Stability and Subjective Results of Tecnis Eyhance Toric II Intraocular Lens.","authors":"Dana Toameh, Heather O'Donnell, Stephanie Wise, Kaivon Pakzad-Vaezi, Gregory Moloney","doi":"10.2147/OPTH.S515517","DOIUrl":"10.2147/OPTH.S515517","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate rotational stability and patient-reported outcomes associated with Tecnis Eyhance toric II \"monofocal plus\" intraocular lens (IOL), particularly in light of a modified haptic design.</p><p><strong>Methods: </strong>A prospective, interventional study was conducted with patients undergoing routine cataract surgery and Tecnis Eyhance toric II IOL implantation. The inclusion criteria were topographic corneal astigmatism of 0.5-4.0D. Exclusion criteria included previous corneal or ocular surgeries, mesopic pupils >5.5mm, wear of rigid gas-permeable contact lenses, and ophthalmic pathologies that might limit vision outcomes. Toric stability was assessed on day 1, week 1, and month 3 using slit-lamp exams and toriCAM app. Quality of Vision (QoV) and Near Activity Visual Questionnaires (NAVQ) before the surgery and 3 months post-operatively.</p><p><strong>Results: </strong>The study analyzed 98 eyes from 65 patients. Mean absolute IOL rotation was 1.73±1.64° (range: 0-7°) from day 1 to week 1, with 95% rotating ≤5°. From week 1 to month 3, mean rotation was 1.13±1.53° (range: 0-8°), with 98% rotating ≤5°.</p><p><strong>Conclusion: </strong>The data from this study suggest that the Tecnis Eyhance toric II IOL exhibits good postoperative rotational stability and positive patient-reported visual outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"3011-3017"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}