Clinical ophthalmology (Auckland, N.Z.)最新文献

{"title":"Impact of Dry Age-Related Macular Degeneration on Daily Activities and Quality of Life: Interview Findings From Patients and Caregivers Relative to a General Population.","authors":"Christina X Chamberlain, Antonia Morga, Yan Song, Marie Louise Edwards, Annika Anderson, Kirthana Sarathy, Dana Christensen, Alessandro Iannaccone, Jun Su","doi":"10.2147/OPTH.S496201","DOIUrl":"10.2147/OPTH.S496201","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate impacts of dry age-related macular degeneration (AMD) on patients and caregivers.</p><p><strong>Patients and methods: </strong>Semi-structured interviews were conducted with patients with dry AMD, caregivers, and controls (individuals without dry AMD, of similar age, sex, and comorbidity profile to patients) between March 2021 and June 2023. Patients aged ≥50 years, with a best corrected visual acuity (BCVA) score from the most recent eye exam after dry AMD diagnosis, were enrolled from the US and UK. Controls with mild visual impairment and unpaid adult caregivers of patients were also enrolled. Main outcomes were functional impairment impact on daily activities, quality of life (QoL), and mental health among patients relative to controls; dry AMD impact on patient daily activities from caregiver perspective; caregiver work productivity, QoL, and burden.</p><p><strong>Results: </strong>Thirty patients, 20 controls, and 20 caregivers were interviewed. Patients had a mean age of 65.1 years; 63.3% were female, 83.3% were White, and 96.7% were from the US. Visual impairment based on BCVA score was mild in 70.0% and moderate to severe in 30.0% of patients. Most patients reported problems performing usual activities, whereas most controls experienced no or mild problems. More daily activities in the past month were affected by dry AMD in patients than by visual impairment in controls (mean 4.5 and 2.1), with reading, shopping, and hobbies being most commonly affected in patients. More patients than controls experienced emotional problems. Patients with moderate-to-severe visual impairment reported more impact on activities relative to those with mild visual impairment. Most caregivers were employed, with 46.2% reporting their work productivity was affected at least sometimes, and many experienced mental and emotional burdens and impacts on their daily lives.</p><p><strong>Conclusion: </strong>Dry AMD impaired the functional ability of patients regardless of visual impairment level and posed significant burdens to caregivers.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"599-615"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Trial Comparing Prediction Accuracy of Three Biometers in Short, Medium, and Long Eyes.","authors":"Sam Multack, Nellie Plummer, Athanasios Marneris, Brad Hall","doi":"10.2147/OPTH.S487889","DOIUrl":"10.2147/OPTH.S487889","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the non-inferiority of mean absolute prediction error (APE) of the Argos (Movu, a Santec company) compared with the IOL Master 700 (Carl Zeiss Meditec AG) and Lenstar LS900 (Haag-Streit AG) biometers utilizing the Barrett Universal II (BUII) formula for power calculations in short, medium, and long axial length eyes.</p><p><strong>Methods: </strong>This was a retrospective chart review of prediction error from 3 biometers (Argos, IOLMaster 700, and Lenstar LS900). Biometer measurement order was determined using blocked randomization. Eligible charts were from eyes 50-85 years old, axial length between 20.00 mm and 30.00 mm, and had IOL implantation with the AcrySof IQ monofocal IOL (SN60WF) and AcrySof toric IOL (SN6AT3, SN6AT4). Preoperative planning was done with the BUII formula on all biometers, with a target of plano. The primary outcome measure was the mean absolute prediction error for each biometer using BUII. Specifically, the non-inferiority of Argos compared to the IOLMaster 700 and Lenstar LS900 using a non-inferiority margin of 0.25 D.</p><p><strong>Results: </strong>The chart review identified 203 eyes from 123 patients. Mean APE for Argos overall and for each axial length group was non-inferior to that of IOLMaster 700 and Lenstar LS900. The overall mean APE was 0.25 ± 0.20 D for Argos compared to 0.25 ± 0.20 D for IOLMaster 700, and 0.25 ± 0.19 D for Lenstar LS900. The differences were not significant (p > 0.05). The percentages of eyes with APE 0.5 D or less were 90% for Argos, 89% for IOLMaster 700, and 89% for Lenstar LS900. The differences were not significant (p > 0.05).</p><p><strong>Conclusion: </strong>Overall mean APE was not significantly different with the Argos compared to IOLMaster 700 and Lenstar LS900 using the BUII formula, suggesting that the use of any of these devices can achieve good outcomes.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"577-583"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Corneal Thickness and Glaucoma Risk: The Importance of Corneal Pachymetry in Screening Adults Over 50 and Glaucoma Suspects.","authors":"David Agbato, Kara Rickford, Daniel Laroche","doi":"10.2147/OPTH.S498422","DOIUrl":"10.2147/OPTH.S498422","url":null,"abstract":"<p><p>Glaucoma is a leading cause of preventable blindness, yet nearly half of those affected are unaware of their diagnosis. Individuals with glaucoma may present with \"normal\" or \"lower\" intraocular pressure (IOP) compared to typical glaucoma thresholds, due in large part to many of these individuals having thin corneas. Conversely, many with elevated IOP and thicker corneas may not necessarily have glaucoma. In this article, we review the importance of central corneal thickness (CCT) and corneal pachymetry devices in eye care. Additionally, we review the role of corneal thickness as a risk factor for glaucoma and glaucoma progression. PubMed and Web of Science databases were searched for articles and reviews on corneal pachymetry and its use in glaucoma, corneal biomechanics and refractive surgery, and glaucoma screening. The results of this review revealed that CCT is a risk factor for development of glaucoma, and in eyes suspected of glaucoma, corneal pachymetry can be performed by trained technicians to provide important information related to the risk of acquiring glaucoma and/or having other ocular diseases. Additionally, a lower CCT is associated with an increased risk of progression and faster rates of visual field loss in eyes with glaucoma. This review will provide evidence regarding the importance of performing corneal pachymetry on all persons over the age of 50 as part of a comprehensive eye examination to better identify those patients who have glaucoma or are glaucoma suspects.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"563-570"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Diabetic Retinopathy in an Outpatient Podiatry Clinic and Associated Barriers to Ophthalmic Care.","authors":"Alessandra M Larimer-Picciani, Richard B Brown, Heqiao Ruan, Crandall E Jones, Richelle N DeBlasio, Patrick R Burns, Andrew M Williams, Evan L Waxman","doi":"10.2147/OPTH.S499098","DOIUrl":"10.2147/OPTH.S499098","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is a leading cause of vision loss among working-age adults. However, the prevalence of DR among patients with diabetic foot disease-a signal of advanced systemic diabetes complications-is underexplored. Additionally, the substantial comorbidity burden associated with diabetic foot disease may result in a higher incidence of or distinct barriers to ophthalmic care, including structural (access to healthcare), behavioral (prioritization of care), and economic (cost of care) factors, compounding risk of vision loss. This study assesses the prevalence of DR in a podiatric clinic while also investigating participant-reported barriers to routine ophthalmic follow-up.</p><p><strong>Methods: </strong>We conducted a cross-sectional study that included patients age ≥18 (n=62) receiving diabetic foot care at an outpatient podiatric clinic in 2021 and 2022. DR status was determined through point-of-care digital retinal images or prior DR diagnosis documented in the electronic medical record. Retinal images were interpreted remotely by a board-certified ophthalmologist. Self-reported barriers to regular ophthalmic care were recorded among participants who were lost to follow-up ophthalmic care. Participants were also surveyed for favorable incentives to promote ophthalmic follow-up.</p><p><strong>Results: </strong>Our findings revealed a high prevalence of DR, with 32 (54%) participants diagnosed with DR and 10 (17%) participants having sight-threatening DR. Notably, 17 (29%) participants were newly diagnosed with DR as a direct result of this study. Of the 62 participants enrolled, 29 (47%) were lost to ophthalmic care. All of these participations reported one or more barriers to receiving ophthalmic care, predominantly related to competing social, economic, and medical challenges, with ophthalmic care being chronically underprioritized. Financial incentives were most favored by participants as an effective means to promote ophthalmic follow-up.</p><p><strong>Conclusion: </strong>The high prevalence of DR, especially undiagnosed DR, in conjunction with significant barriers to ophthalmic care highlights a critical need for improved screening in outpatient podiatric settings. Integrating digital fundus cameras into outpatient podiatric clinic workflow may enhance DR detection and prevent vision loss in this high-risk population. Addressing identified barriers to routine ophthalmic care may further improve the rate of follow-up care and reduce the burden of DR-related vision loss among patients with diabetic foot disease.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"553-561"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors for Ocular Complications in New-Onset Uveitis: A Study From a Tertiary Referral Center in Northern Thailand.","authors":"Atitaya Apivatthakakul, Apichat Tantraworasin, Aniki Rothova, Paradee Kunavisarut, Kessara Pathanapitoon","doi":"10.2147/OPTH.S500339","DOIUrl":"10.2147/OPTH.S500339","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence and identify risk factors of ocular complications in patients with uveitis.</p><p><strong>Methods: </strong>This retrospective study reviewed of 340 consecutive patients with a first episode of active uveitis from January 2015 to December 2019. Demographic and clinical data, including ocular complications were analyzed.</p><p><strong>Results: </strong>The mean age of the cohort was 47 years. Among them, 75 patients were HIV-positive (74% male), and 265 were HIV-negative (53% male). An Infectious etiology was identified in 52% of cases. Ocular complications, developed in 151 patients (44%), with their type strongly correlate to the anatomical location of uveitis. Multivariate analysis revealed chronic inflammation (risk ratio [RR]=18.9; 95% confidence interval [CI] 6.1-58.8), recurrent inflammation (RR=20.4; 95%; CI 6.5-64.3), and poor visual acuity (VA) at presentation (RR=3.6; 95% CI 1.4-9.2) as significant risk factors for complications.</p><p><strong>Conclusion: </strong>Nearly half of the patients with uveitis developed ocular complications, highlighting the importance of identifying risk factors. Understanding the relationship between the location of inflammation and specific complication patterns is essential for early detection and targeted prevention strategies.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"543-551"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocidal Efficacies of Contact Lens Disinfecting Solutions Against Gram-Negative Organisms Associated with Lens Case-Associated Corneal Infiltrative Events.","authors":"Jennifer Corwin-Buell, Denise Callahan, Deborah McGrath, Kimberly Millard, Gary Mosehauer, Marjorie J Rah, Nitasha Phatak","doi":"10.2147/OPTH.S477777","DOIUrl":"10.2147/OPTH.S477777","url":null,"abstract":"<p><strong>Background: </strong>Multi-purpose solutions (MPSs) are designed to clean, disinfect, and condition contact lenses (CLs) to reduce the risk of contact lens-related adverse events, such as corneal infiltrative events (CIEs) that are often associated with opportunistic bacteria from contaminated CLs or CL cases. This study evaluated the disinfection efficacies of six MPSs and one hydrogen peroxide solution (HPS) comparator against three lens case CIE-associated organisms.</p><p><strong>Methods: </strong>The solutions in this study were evaluated against commonly isolated Gram-negative lens case CIE-associated organisms in the presence of organic soil, according to the International Organization for Standardization 14729 (ISO) stand-alone test protocol. Challenge organisms (<i>Achromobacter xylosoxidans, Delftia acidovorans</i> and <i>Stenotrophomonas maltophilia</i>) were inoculated into the solutions in conical tubes (for MPS) or CL cases (for HPS), and plated for organism quantification after the manufacturer-recommended minimum soak times. Disinfection efficacy for each solution is presented as mean log reduction per organism and overall disinfection across three challenge organisms (post hoc analysis).</p><p><strong>Results: </strong>Stand-alone testing against the challenge organisms demonstrated that PAPB/Alexidine/PQ-1, Alexidine/PQ-1, and PHMB-containing MPSs, as well as HPS were significantly superior versus MAPD/PQ-1-based MPSs (all p < 0.05). While there is no ISO criteria for reduction of CIE-associated organisms, all solutions containing PAPB/Alexidine/PQ-1, Alexidine/PQ-1, and PHMB, as well as HPS, achieved greater than 3-log reductions (the primary criteria for ISO 14729 compendial bacterial organisms) for all challenge organisms. The three MAPD/PQ-1-containing MPSs achieved between 0.6 and 1.7 log reduction across the MPS/test organism combinations.</p><p><strong>Conclusion: </strong>The PAPB, PHMB, and Alexidine-based MPSs demonstrated significantly greater disinfection efficacy than MAPD-based MPSs, and comparable disinfection efficacy to HPS, against commonly isolated Gram-negative CL case CIE-associated organisms.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"519-526"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Plungerless Injector Device (IPLID): An Innovative Intravitreal Injector Device.","authors":"Juan B Yepez, Felipe A Murati, Michele Petitto, Igor Kozak, J Fernando Arevalo","doi":"10.2147/OPTH.S494755","DOIUrl":"10.2147/OPTH.S494755","url":null,"abstract":"<p><strong>Purpose: </strong>To share our early experience with the novel intravitreal plungerless injector device (IPLID) for application in patients with various retinal diseases.</p><p><strong>Patients and methods: </strong>This study enrolled 300 eyes (300 patients) who had undergone at least 1 previous conventional intravitreal injection, for various indications, such as diabetic macular edema, venous occlusions, active choroidal neovascular membrane, wet AMD and neovascular glaucoma. Patients with systemic conditions that could affect pain tolerance were excluded. All patients underwent intravitreal injection with the IPLID. After the procedure the patients were asked to grade pain compared to conventional injections. Immediately after the procedure, surgeons completed a simple survey on various aspects of the device, including safety of the procedure. Data were also collected on the duration of the procedure.</p><p><strong>Results: </strong>The study sample was comprised of 210 males and 90 females. The mean duration of the injection was 17.51 minutes (range, 15 minutes to 20 minutes). Post-IPLID injection, 155 (51.7%) patients reported less pain compared to previous injections, 128 (42.7) patients reported pain similar to previous injections and 5.7% (17) of patients reported more pain than previous procedures. The physician survey indicated that there was no difference between IPLID and conventional technique in 13.33% (40) of injections, and 86.67% (260) of the injections were comfortable to perform with the IPLID and size was not an issue in 91.67% (275) of injections. In all cases, the surgeons were comfortable with the delivery of medication with IPLID and there were no adverse events during or after IPLID injection.</p><p><strong>Conclusion: </strong>The IPLID is a simple device for delivering intravitreal injection and may offer greater ergonomic advantages and that address the issue of musculoskeletal disorders in healthcare personnel due to repetitive procedures over time.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"535-541"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic Therapeutic Keratopigmentation.","authors":"Bruno Lovaglio Cançado Trindade, Isadora Brito Coelho, Larissa Lima Magalhães, Letícia Arriel Crepaldi, Frederico Moreira Man Fu, Luiza Machado Ribeiro Da Glória","doi":"10.2147/OPTH.S507490","DOIUrl":"10.2147/OPTH.S507490","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze indications safety and potential complications of cosmetic therapeutic corneal keratopigmentation to treat disfiguring aspect of opaque corneas.</p><p><strong>Methods: </strong>Eight eyes of 8 consecutive patients were enrolled in therapeutic corneal keratopigmentation. Surgery was performed using manual technique, and a two-plane corneal dissection was performed. In the deeper pocket, brown pigment was injected to mimic iris color. In the more superficial and smaller pocket, black pigment was used to simulate pupillary opening.</p><p><strong>Results: </strong>Seven out of 8 eyes had significant improvements in cosmesis after surgery. One patient did not have a major improvement due to significant superficial corneal neovascularization. In two eyes, there was pigment fading in the postoperative period, but no additional surgeries were performed. No complications were noted in any of the patients.</p><p><strong>Conclusion: </strong>Therapeutic corneal keratopigmentation can lead to a significant change in ocular appearance and may improve self-esteem and overall life quality. Pigment fading and corneal neovascularization can be a potential problem. Careful patient selection and counseling are important to avoid patients seeking unachievable results.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"527-534"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of Ocular Trauma Resulting From Pediatric Sports Injuries.","authors":"Aysha Chaudhary, Evan W Carr, Frank Bogan, Jeffrey Xiao Liu, Amir R Hajrasouliha","doi":"10.2147/OPTH.S493655","DOIUrl":"10.2147/OPTH.S493655","url":null,"abstract":"<p><strong>Purpose: </strong>Although sports participation among pediatric patients benefits overall development, the risks of ocular trauma are often overlooked. This retrospective cohort study investigated sports groups to determine which caused the greatest ocular trauma and initial presenting visual acuity (VA) impairment.</p><p><strong>Patients and methods: </strong>1,290 pediatric ocular traumas in two Indianapolis tertiary care centers over a 10-year period were collected and stratified based on sport category, injury type, age, and need for surgical intervention. Chi-square analysis and Fisher exact testing were used to determine each variable's significance.</p><p><strong>Results: </strong>Ocular injuries were most commonly attributed to baseball (38.5%), basketball (16.9%), and soccer (14.9%). The most common ocular diagnoses were contusions (82.4%) and hyphemia (8.1%). Orbital fractures were the most common diagnosis requiring surgery (54.5%) with baseball as the most common cause (67.0%) of these fractures. Analysis of significant visually impairing traumas indicated that golf and archery were the most detrimental in initial presenting VA followed by football and baseball. Lastly, children aged 0-11 years old (p = <0.01) most commonly had injuries attributable to baseball (p = <0.01) whereas older children aged 12-18 more commonly had injuries attributable to soccer (p= 0.04) and football (p=0.04).</p><p><strong>Conclusion: </strong>With our study illustrating that archery and golf were the most detrimental on initial presenting VA while baseball was the most common cause of impactful injuries, particularly among children aged 3-11 years, safety guidelines should include mandatory eye protection to decrease the risk of sport-related ocular injury.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"507-517"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome.","authors":"Suping Wu, Wenting Wang, Lei Liu, Wei Wang, Keke Jiang, Chuanzhi Peng, Huixin Sun, Jie Zhang","doi":"10.2147/OPTH.S505086","DOIUrl":"https://doi.org/10.2147/OPTH.S505086","url":null,"abstract":"<p><p>Morning glory syndrome (MGS) is a rare congenital optic disc malformation characterized by a distinctive funnel-shaped optic disc resembling a blooming morning glory flower, typically diagnosed in childhood or adolescence and primarily presenting unilaterally, although bilateral cases have been reported. The anomaly features an enlarged optic disc, radiating blood vessels, and surrounding excavation, leading to visual impairment that can range from mild to profound. The etiology of MGS is not fully understood but has been associated with genetic factors, particularly mutations in the PAX6 and PAX2 genes, which play critical roles in eye development. MGS is often linked with other ocular and systemic anomalies, including retinal detachment, a significant complication that may be exudative, tractional, or rhegmatogenous. Surgical interventions are generally employed to manage complications, especially retinal detachments, with procedures such as vitrectomy, paraoptic disc laser photocoagulation, and the use of silicone oil or gas tamponade, though success rates can vary widely. Long-term outcomes for patients with MGS largely depend on the severity of associated complications and the timing of interventions; while some individuals may attain reasonable visual function post-treatment, others may continue to experience challenges due to the underlying malformation and its consequences. Thus, MGS remains a complex condition requiring a multidisciplinary approach for effective management and enhanced patient outcomes, emphasizing the need for continued research into its genetic underpinnings and optimal treatment strategies to improve understanding and care for those affected.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"459-468"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}