{"title":"VISULYZE-Generated nomogram辅助KLEx矫正近视和散光：3个月的随访结果。","authors":"Qi Wan, Ran Wei, Jing Tang, Ying-Ping Deng, Ke Ma","doi":"10.2147/OPTH.S551923","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy, safety, and predictability of Keratorefractive Lenticule Extraction (KLEx) surgery guided by a VISULYZE-generated nomogram for myopia and astigmatism correction.</p><p><strong>Methods: </strong>This prospective cohort study included 130 consecutive patients (260 eyes) undergoing KLEx surgery using a VISULYZE-generated nomogram. Patients were followed for 3 months postoperatively. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and spherical equivalent (SE). \"Nine Standard Graphs\" were generated using VISULYZE software and analyzed according to international standards for evaluating the quality of corneal refractive surgery. Subgroup analyses based on age (≤30 years vs >30 years) and preoperative SE (≤-6.00 D vs >-6.00 D) were performed.</p><p><strong>Results: </strong>At 3 months postoperatively, 96% of eyes achieved UDVA of 20/20 or better, and 96.2% maintained or improved CDVA compared to preoperatively. No eyes lost 1 or more lines of CDVA. The correlation coefficient (R²) between attempted and achieved SE was 0.9732. 98.1% of eyes were within ±0.50 D of the attempted SE. 99.2% of eyes achieved a postoperative cylinder ≤0.50 D. Subgroup analysis revealed that older patients (>30 years) had slightly lower UDVA compared to younger patients, while high myopes (≤-6.00 D) showed a trend towards slight under-correction and lower efficacy compared to moderate and low myopes. However, astigmatism correction was comparable between subgroups.</p><p><strong>Conclusion: </strong>KLEx surgery guided by a VISULYZE-generated nomogram demonstrates excellent efficacy, safety, and predictability for myopia and astigmatism correction. While age and preoperative myopia degree may subtly influence efficacy, the nomogram provides a valuable tool for personalized surgical planning. Further research is warranted to refine nomogram development, particularly for older and highly myopic patients.</p>","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"2985-2995"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399896/pdf/","citationCount":"0","resultStr":"{\"title\":\"VISULYZE-Generated Nomogram-Assisted KLEx for Myopia and Astigmatism Correction: 3-Month Follow-Up Results.\",\"authors\":\"Qi Wan, Ran Wei, Jing Tang, Ying-Ping Deng, Ke Ma\",\"doi\":\"10.2147/OPTH.S551923\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the efficacy, safety, and predictability of Keratorefractive Lenticule Extraction (KLEx) surgery guided by a VISULYZE-generated nomogram for myopia and astigmatism correction.</p><p><strong>Methods: </strong>This prospective cohort study included 130 consecutive patients (260 eyes) undergoing KLEx surgery using a VISULYZE-generated nomogram. Patients were followed for 3 months postoperatively. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and spherical equivalent (SE). \\\"Nine Standard Graphs\\\" were generated using VISULYZE software and analyzed according to international standards for evaluating the quality of corneal refractive surgery. Subgroup analyses based on age (≤30 years vs >30 years) and preoperative SE (≤-6.00 D vs >-6.00 D) were performed.</p><p><strong>Results: </strong>At 3 months postoperatively, 96% of eyes achieved UDVA of 20/20 or better, and 96.2% maintained or improved CDVA compared to preoperatively. No eyes lost 1 or more lines of CDVA. The correlation coefficient (R²) between attempted and achieved SE was 0.9732. 98.1% of eyes were within ±0.50 D of the attempted SE. 99.2% of eyes achieved a postoperative cylinder ≤0.50 D. Subgroup analysis revealed that older patients (>30 years) had slightly lower UDVA compared to younger patients, while high myopes (≤-6.00 D) showed a trend towards slight under-correction and lower efficacy compared to moderate and low myopes. However, astigmatism correction was comparable between subgroups.</p><p><strong>Conclusion: </strong>KLEx surgery guided by a VISULYZE-generated nomogram demonstrates excellent efficacy, safety, and predictability for myopia and astigmatism correction. While age and preoperative myopia degree may subtly influence efficacy, the nomogram provides a valuable tool for personalized surgical planning. Further research is warranted to refine nomogram development, particularly for older and highly myopic patients.</p>\",\"PeriodicalId\":93945,\"journal\":{\"name\":\"Clinical ophthalmology (Auckland, N.Z.)\",\"volume\":\"19 \",\"pages\":\"2985-2995\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399896/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical ophthalmology (Auckland, N.Z.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/OPTH.S551923\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical ophthalmology (Auckland, N.Z.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/OPTH.S551923","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：评价在visulyze生成图引导下角膜屈光性晶状体摘除（KLEx）手术矫正近视和散光的有效性、安全性和可预测性。方法：这项前瞻性队列研究包括130例连续患者（260只眼睛），使用visulyze生成的图进行KLEx手术。术后随访3个月。主要观察指标为未矫正距离视力（UDVA）、矫正距离视力（CDVA）和球面等效视力（SE）。使用VISULYZE软件生成“九张标准图”，并按照评估角膜屈光手术质量的国际标准进行分析。根据年龄（≤30岁vs bb - 30岁）和术前SE（≤-6.00 D vs bb -6.00 D）进行亚组分析。结果：术后3个月，96%的眼UDVA达到20/20及以上，96.2%的眼保持或改善了CDVA。没有眼睛失去1行或更多的CDVA。尝试SE与实现SE的相关系数（R²）为0.9732。98.1%的眼睛在±0.50 D范围内。99.2%的眼达到了术后圆柱体≤0.50 D，亚组分析显示，老年患者（bb0 ~ 30岁）的UDVA较年轻患者略低，而高度近视（≤-6.00 D）的患者与中、低度近视患者相比，有轻微矫正不足的趋势，疗效较低。然而，亚组之间的散光校正是可比性的。结论：在visulyze生成的图图指导下，KLEx手术对近视和散光矫正具有良好的疗效、安全性和可预测性。虽然年龄和术前近视程度可能会微妙地影响疗效，但nomographic为个性化手术计划提供了有价值的工具。进一步的研究是必要的，以完善nomogram发展，特别是对老年人和高度近视患者。
VISULYZE-Generated Nomogram-Assisted KLEx for Myopia and Astigmatism Correction: 3-Month Follow-Up Results.
Purpose: To evaluate the efficacy, safety, and predictability of Keratorefractive Lenticule Extraction (KLEx) surgery guided by a VISULYZE-generated nomogram for myopia and astigmatism correction.
Methods: This prospective cohort study included 130 consecutive patients (260 eyes) undergoing KLEx surgery using a VISULYZE-generated nomogram. Patients were followed for 3 months postoperatively. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and spherical equivalent (SE). "Nine Standard Graphs" were generated using VISULYZE software and analyzed according to international standards for evaluating the quality of corneal refractive surgery. Subgroup analyses based on age (≤30 years vs >30 years) and preoperative SE (≤-6.00 D vs >-6.00 D) were performed.
Results: At 3 months postoperatively, 96% of eyes achieved UDVA of 20/20 or better, and 96.2% maintained or improved CDVA compared to preoperatively. No eyes lost 1 or more lines of CDVA. The correlation coefficient (R²) between attempted and achieved SE was 0.9732. 98.1% of eyes were within ±0.50 D of the attempted SE. 99.2% of eyes achieved a postoperative cylinder ≤0.50 D. Subgroup analysis revealed that older patients (>30 years) had slightly lower UDVA compared to younger patients, while high myopes (≤-6.00 D) showed a trend towards slight under-correction and lower efficacy compared to moderate and low myopes. However, astigmatism correction was comparable between subgroups.
Conclusion: KLEx surgery guided by a VISULYZE-generated nomogram demonstrates excellent efficacy, safety, and predictability for myopia and astigmatism correction. While age and preoperative myopia degree may subtly influence efficacy, the nomogram provides a valuable tool for personalized surgical planning. Further research is warranted to refine nomogram development, particularly for older and highly myopic patients.
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