BMC Urology最新文献

{"title":"A hypervascular perivascular epithelioid cell tumor of the urinary bladder showing TFE3 immunoreactivity clinically misdiagnosed as paraganglioma in an adolescent patient.","authors":"Minjie Ou, Chongjun Ji, Jin Wen","doi":"10.1186/s12894-026-02205-2","DOIUrl":"10.1186/s12894-026-02205-2","url":null,"abstract":"<p><p>Perivascular epithelioid cell tumor (PEComa) of the urinary bladder is an exceptionally rare mesenchymal neoplasm and may be difficult to diagnose preoperatively. We report a rare case of a hypervascular bladder PEComa with TFE3 expression in an adolescent female that was clinically misdiagnosed as paraganglioma. A 16-year-old girl presented with intermittent gross hematuria. Imaging revealed a hypervascular submucosal bladder mass with marked homogeneous enhancement on computed tomography urography (CTU) and mild-to-moderate uptake on somatostatin receptor imaging, leading to suspicion of paraganglioma and preoperative α-adrenergic blockade. Histopathologic examination after transurethral resection showed epithelioid tumor cells with a low proliferative index. Immunohistochemistry demonstrated nuclear TFE3 positivity and strong cathepsin K expression, while melanocytic and neuroendocrine markers were negative, supporting a diagnosis of PEComa showing TFE3 immunoreactivity. The patient remains disease-free at six months of follow-up. This case highlights an important diagnostic pitfall of hypervascular bladder tumors mimicking paraganglioma, particularly in adolescent patients.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative foreign body retention following anal injury leading to a giant bladder stone: a case report.","authors":"Shuhong Wang, Yin Tian, Xiangui Zhou, Peng Wang, Peng Ye, Yuanlan Lu, Anyong Yu","doi":"10.1186/s12894-026-02210-5","DOIUrl":"10.1186/s12894-026-02210-5","url":null,"abstract":"<p><strong>Purpose: </strong>Penetrating anal injuries resulting from falls from height are a rare form of high-energy trauma, often accompanied by multiple organ injuries and delayed complications; giant bladder stones caused by retained wooden foreign bodies are particularly rare and highly prone to misdiagnosis. This study reports a case of this rare condition and highlights the key factors for achieving the best possible outcome.</p><p><strong>Methods: </strong>This study presents the case of a 14-year-old male patient who sustained multiple penetrating anal injuries caused by a wooden foreign body following a fall from a height. Abdominal CT was used to assess the location of the foreign body and the extent of organ injury; the patient underwent emergency open abdominal surgery and transcatheter arterial embolisation for haemostasis, followed by long-term follow-up involving further imaging and interventional procedures as new symptoms arose.</p><p><strong>Results: </strong>Initial abdominal CT revealed a foreign body in the abdomen and pelvis, accompanied by ileal and bladder injuries. Gross hematuria was present at admission, and urinary catheterization was maintained for 14 days postoperatively. The patient was discharged on postoperative day 20. Following emergency surgery and embolisation, the patient was discharged on the 20th postoperative day. Eight and a half years later, the patient developed lower urinary tract symptoms; a urinary tract CT scan revealed a giant bladder stone surrounding the residual foreign body, and the patient made a full recovery following surgical removal.</p><p><strong>Conclusion: </strong>For such patients, early and accurate diagnosis, prompt emergency surgery, thorough intraoperative exploration, objective assessment of bladder healing, and continuous long-term follow-up are crucial for preventing late complications and achieving the best possible outcomes.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13417852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between renal replacement therapy and in-hospital mortality in patients with severe acute kidney injury: a retrospective cohort study based on MIMIC-IV database.","authors":"Guanyuan Tian, Zhibin Lin, Zhanmao Chen, Zhanyi Qiu, Zheyan Zheng, Yuan Lin, Tietao Chen, Zhonghan Xu, Yubin Cai, Kefei Wu, Xiaoli Li","doi":"10.1186/s12894-026-02206-1","DOIUrl":"10.1186/s12894-026-02206-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Severe acute kidney injury (AKI) occurs frequently in intensive care unit (ICU) settings and correlates strongly with adverse patient outcomes. Whether renal replacement therapy (RRT) can effectively improve mortality outcomes in these patients remains controversial, primarily due to interference from confounding by indication. Within nephrology and critical-care practice, identifying which severe-AKI subgroups derive a survival benefit from RRT is a question of direct bedside relevance, and observational analyses with rigorous bias control are particularly informative when balanced randomised data remain limited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective cohort analysis utilized the MIMIC-IV database (version 2.2). The study population comprised adult patients (age ≥ 18 years) diagnosed with KDIGO Stage 3 AKI during their first ICU admission. Vascular causes of AKI (renal-artery stenosis, renal infarction, abdominal-aortic-aneurysm associated ischaemia) and clearly post-obstructive AKI were excluded a priori, as these phenotypes carry distinct trajectories that may not respond to RRT in a comparable manner. Patients were stratified into treatment and control groups based on RRT receipt. The clinical indication for RRT was operationalised through a composite set of pre-specified criteria (refractory hyperkalaemia, severe metabolic acidosis, refractory volume overload, uraemic complications, and oligo-anuria) that were entered into the propensity-score model in addition to severity scores and laboratory derangement, in order to reduce residual operator-dependent variation in the initiation decision. To address baseline characteristic differences, propensity score matching (PSM) was conducted using 1:1 nearest neighbor matching with a caliper of 0.02. The primary endpoint was in-hospital all-cause mortality; secondary endpoints encompassed ICU mortality, 28-day mortality, ICU length of stay, total hospital length of stay, RRT-related complications (catheter-associated bloodstream infection, mechanical line complications, bleeding events, and intradialytic hypotension), and renal recovery. Cox proportional hazards regression models were employed to calculate hazard ratios (HRs) with corresponding 95% confidence intervals (CIs). Pre-specified subgroup analyses also stratified by chronic-kidney-disease status, RRT modality, and the qualifying KDIGO Stage-3 criterion (creatinine, urine output, or both).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 5,847 patients with KDIGO Stage 3 AKI were enrolled, of whom 2,156 (37%) underwent RRT. Pre-matching analysis revealed substantially greater disease severity in the RRT group (SOFA score: 12.4 ± 4.2 vs. 8.6 ± 3.8, P &lt; 0.001). Following 1:1 PSM, 1,842 matched pairs were established, with all covariate standardized mean differences (SMDs) below 0.1, indicating satisfactory matching. Within the matched cohort, in-hospital mortality was lower in the RRT group than in the con","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of treatment and oncological outcomes in patients undergoing radical cystectomy: a comparative analysis across two decades at a tertiary center.","authors":"Caio Vinícius Suartz, Maria Fernanda Dias Azevedo, Pedro Henrique Souza Brito, Débora Narumi Demitrol Setoue, Caio Mazzoneto Teófilo de Moraes, Pedro Vasconcelos Henry Sant'Anna, Luiz Guilherme Pereira da Silva, Leonam Bringhenti Schumacher, Victor Vion Sant Galvez, Maurício Cordeiro Dener, William Carlos Nahas, Leopoldo Alves Ribeiro-Filho","doi":"10.1186/s12894-026-02166-6","DOIUrl":"10.1186/s12894-026-02166-6","url":null,"abstract":"<p><strong>Background: </strong>Over the last two decades, significant advances in the perioperative management of muscle-invasive bladder cancer, such as enhanced recovery protocols, increased use of neoadjuvant chemotherapy, improved care pathways, and stronger multidisciplinary collaboration, have reshaped surgical outcomes. This study aimed to evaluate the evolution of care and oncological outcomes in patients undergoing radical cystectomy at a Brazilian tertiary cancer center over 20 years.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical, surgical, and pathological data from patients with bladder cancer who underwent radical cystectomy between January 2005 and April 2025. Patients were stratified into two cohorts according to the year of surgery (2005-2014 vs. 2015-2025). Survival analyses were performed using Kaplan-Meier curves to compare overall survival, cancer-specific survival, and recurrence-free survival between periods.</p><p><strong>Results: </strong>A total of 733 patients were included (mean age, 66.2 years; 69.2% male). An age-adjusted Charlson Comorbidity Index ≥ 3 was present in 90.4%, and preoperative hydronephrosis in 41.5%. Locally advanced disease (pT3-pT4) occurred in 50.9%, lymph node positivity (pN+) in 26.6%, and 34.5% received neoadjuvant chemotherapy. Early complications (< 30 days) occurred in 51.2%, early reoperation in 19.3%, and late complications (30-90 days) in 24.0%, with 33.3% classified as Clavien-Dindo grade ≥ III. On multivariable Cox regression, treatment period remained independently associated with improved overall survival (HR 0.75, 95% CI 0.58-0.97; p = 0.029). Clinical stage was also independently associated with overall survival (overall p = 0.046), with advanced stage increasing the hazard of death (HR 1.48, 95% CI 1.08-2.02; p = 0.015). Kaplan-Meier analysis showed significantly improved overall, cancer-specific, and recurrence-free survival in 2015-2025 versus 2005-2014 (all log-rank p < 0.001).</p><p><strong>Conclusion: </strong>Improved survival after radical cystectomy over the last decade reflects advances in perioperative care in the management of bladder cancer patients undergoing radical cystectomy.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal venous hypertension secondary to nutcracker syndrome-a previously unreported cause of congestive myelopathy.","authors":"Fan Chang, Song Li, Yongjia Zhou, Kai Li, Shuai Tang, Zhen Ma, Jing Zhang, Fangmin Chen","doi":"10.1186/s12894-026-02185-3","DOIUrl":"10.1186/s12894-026-02185-3","url":null,"abstract":"<p><strong>Objective: </strong>We report a case of myelopathy associated with nutcracker syndrome. Clinical and imaging findings indicate that nutcracker syndrome caused left renal vein stenosis, resulting in spinal venous hypertension.</p><p><strong>Case presentation: </strong>A 15-year-old girl presented with abnormal sensations in both lower limbs, followed by progressive motor impairment and bowel and bladder dysfunction. Magnetic resonance imaging (MRI) revealed an abnormal signal in the spinal cord at the T12-L1 level. Although she was initially diagnosed with acute transverse myelitis (ATM) and treated with intravenous steroids, cerebrospinal fluid (CSF) analysis showed no signs of inflammation. Further evaluation with Doppler ultrasound and left renal arteriovenous angiography suggested that nutcracker syndrome led to compression of the left renal vein, with aberrant venous branches draining into the spinal venous system. This resulted in spinal venous hypertension and subsequent spinal cord injury. Initial treatment with corticosteroids and immunoglobulins was discontinued due to disease progression. After identifying a left renal vein vascular malformation at an external hospital, balloon dilation of the left renal vein was performed, yielding mild symptomatic relief. Subsequent interventional embolization of the malformed vessels temporarily improved symptoms, though her condition later deteriorated. Ultimately, she underwent laparoscopic robot-assisted external stent placement in the left renal vein at our institution. During the three-month postoperative follow-up, sensory function gradually improved and the clinical condition stabilized.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first reported case of spinal venous hypertension syndrome secondary to nutcracker syndrome, presenting as myelopathy. We emphasize that in cases of acute myelitis or spinal cord disease of unknown etiology, screening for extramedullary vascular abnormalities-such as left renal artery or vein compression or malformations-should be considered, particularly when inflammatory markers are absent or treatment response is atypical.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of preoperative CT-based 3D visualization model on ureteric access sheath placement failure without pre-stenting.","authors":"Yetong Zhang, Chengda Hu, Han Li","doi":"10.1186/s12894-026-02197-z","DOIUrl":"10.1186/s12894-026-02197-z","url":null,"abstract":"<p><strong>Background: </strong>Placement failure of the flexible and navigable suction ureteral access sheath (FANS) with negative pressure suction may occur during retrograde intrarenal surgery (RIRS) due to ureteral stricture, hemorrhage, injury and other factors. This study aimed to investigate the predictive value of parameters from a 3D visualization model based on preoperative computed tomography (CT) for the failure of FANS placement without pre-stenting.</p><p><strong>Methods: </strong>We retrospectively analyzed the clinical data of 113 patients who underwent RIRS at Chengdu Hospital of Integrated Traditional Chinese and Western Medicine. A 3D visualization model was constructed based on preoperative CT data to measure the lateral ureteral angle, intramural ureteral diameter, intramural ureteral length and pelvic ureteral diameter. A predictive model for failure of FANS placement without pre-stenting was established after univariate and multivariate analyses, and the model performance was evaluated by bootstrap internal validation, calibration curves, decision curve analysis (DCA) etc. RESULTS: Among the 113 patients, significant intergroup differences were observed between the successful placement group (n = 96) and the failed placement group (n = 17) in age (P = 0.010), lateral ureteral angle (P = 0.018), intramural ureteral diameter (P < 0.001) and pelvic ureteral diameter (P = 0.008). No significant intergroup differences were found in body mass index (BMI), stone CT value, stone size, stone number, gender, hydronephrosis, history of ipsilateral lithotripsy, preoperative fever history or intramural ureteral length (P > 0.05). Multivariate analysis identified intramural ureteral diameter (OR = 0.06, 95% CI: 0.01~ 0.29, P < 0.001) and pelvic ureteral diameter (OR = 0.26, 95% CI: 0.08 ~ 0.78, P = 0.017) as protective factors against placement failure, while the lateral ureteral angle (OR = 1.17, 95% CI: 1.04 ~ 1.31, P = 0.006) was a risk factor for placement failure. Due to sample size limitations, the lateral ureteral angle and intramural ureteral diameter were included in the predictive model based on the Bayesian information criterion (BIC). The area under the curve (AUC) of the model was 0.852 (95% CI: 0.763 ~ 0.941), and the AUC of internal validation via Bootstrap resampling (n = 1000) was 0.846 (95% CI: 0.808 ~ 0.860).</p><p><strong>Conclusions: </strong>The intramural ureteral diameter and lateral ureteral angle measured by the 3D visualization model based on preoperative CT are powerful predictors for the failure of FANS placement without pre-stenting. The constructed predictive model exhibits good performance. However, further validation with multi-center and large-sample studies is still required.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Efficacy and safety of mirabegron versus solifenacin in the treatment of overactive bladder in children: a systematic review and meta-analysis.","authors":"Mostafa Shaheen, Omar Mohamed Ali, Abdullah A Draz, Amro K Barakat, Ahmed Elghattas, Toqa Elbaz, Iyad Walid, Tasnim Tarboush, Asmaa Elsayed, Tasneem Mahmoud, Esraa Mohamed Elkhateeb, Abdallah Adel Nofal, Emad Samaan","doi":"10.1186/s12894-026-02179-1","DOIUrl":"10.1186/s12894-026-02179-1","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"26 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive bleeding from a Bricker ileal conduit during FOLFIRINOX therapy in noncirrhotic portal hypertension: suspected oxaliplatin-associated sinusoidal injury and presumed irinotecan-associated conduit mucositis: a case report.","authors":"Rafał Bogdan Drobot, Tymoteusz Ślósarz, Artur Andrzej Antoniewicz","doi":"10.1186/s12894-026-02204-3","DOIUrl":"10.1186/s12894-026-02204-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bleeding from an ileal conduit after radical cystectomy is uncommon and is usually attributed to tumor recurrence, infection, stones, or local stomal trauma. Portal hypertensive stomal varices are rare. FOLFIRINOX adds further diagnostic complexity because oxaliplatin may cause sinusoidal endothelial injury and noncirrhotic portal hypertension, whereas irinotecan may damage gastrointestinal mucosa. We report a case of massive hemorrhage from a long-functioning Bricker ileal conduit during FOLFIRINOX therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case presentation: &lt;/strong&gt;A 72-year-old man with prior radical cystoprostatectomy with Bricker diversion in 2022, robot-assisted left adrenalectomy in 2023, and pancreatic head adenocarcinoma treated with FOLFIRINOX was admitted in February 2026 because of sudden gross hematuria that rapidly filled the urostomy bag with blood and clot. He had received two FOLFIRINOX cycles. With a height of 170 cm and weight of 70 kg, body-surface area was 1.82 m² by the Mosteller formula. Using the standard FOLFIRINOX oxaliplatin dose of 85 mg/m², the reconstructed cumulative oxaliplatin exposure was approximately 170 mg/m², corresponding to about 310 mg in total. Bleeding began 8 days after the most recent irinotecan-containing cycle. Contrast-enhanced computed tomography showed periportal tumor-related changes with a biliary stent, variceal collaterals adjacent to the conduit, and circumferential thickening of the conduit wall, whereas the upper urinary tracts were nondilated and there was no radiologic evidence of recurrent urothelial carcinoma. Looposcopy demonstrated diffusely inflamed and friable conduit mucosa, but biopsy was not performed. Doppler ultrasonography demonstrated portal vein dilatation with preserved hepatopetal flow and no imaging features of cirrhosis. Platelet counts remained within the reference range, and retrospective review of restaging computed tomography showed no interval splenomegaly; the craniocaudal splenic length was approximately 11 cm and unchanged. Urine culture grew extended-spectrum beta-lactamase-producing Escherichia coli and Enterococcus faecalis, but inflammatory markers remained low and there were no clinical features of sepsis. The most cautious interpretation was a mixed mechanism: portal hypertensive stomal varices, possibly related to pancreatic venous distortion and/or early oxaliplatin-associated sinusoidal injury, compounded by presumed irinotecan-associated conduit mucositis. Bleeding ceased with supportive, anti-inflammatory, antimicrobial, transfusion, and nonselective beta-blocker therapy. By May 2026, conduit bleeding had not recurred, although the patient remained chronically unwell with poor ECOG performance status because of the underlying pancreatic cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Massive bleeding from a Bricker conduit during FOLFIRINOX therapy may be multifactorial. Early portal-phase imaging and portal venous assessment are essential wh","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective comparative validation of a novel endoscopy chair and endoscope manipulation apparatus (EasyFlex) for ergonomic improvement in fURS procedures.","authors":"Serdar Toksoz, Alper Asik, Yalcin Kizilkan, Samet Senel, Burak Koseoglu, Erhan Erdogan, Kemal Sarica","doi":"10.1186/s12894-026-02200-7","DOIUrl":"10.1186/s12894-026-02200-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to validate the functionality and usability of a doctor's endoscopy chair and an endoscope carrying/manipulation apparatus known as the EasyFlex.</p><p><strong>Methods: </strong>Prototype models of the EasyFlex apparatus were evaluated by five expert urologists specializing in endourology at three medical centers. The surgical and ergonomic advantages of the doctor's endoscopy chair and the endoscope carrying/manipulation apparatus were compared with those used during traditional flexible ureterorenoscopy (fURS) procedures for kidney stones, with ergonomic outcomes assessed using the Ergomini scale.</p><p><strong>Results: </strong>The ergonomic evaluation of both systems revealed that surgeons experienced significantly greater ergonomic discomfort during traditional fURS procedures compared to those using the EasyFlex system, as indicated by higher total ergonomic scores (37.6 vs. 12.6, p < 0.001). Furthermore, the EasyFlex group demonstrated a significantly lower rate of intraoperative complications than the traditional fURS group (11.8% vs. 27%, p = 0.017).</p><p><strong>Conclusion: </strong>Compared with the traditional approach, the results obtained in our study demonstrated that the EasyFlex apparatus could provide superior ergonomic conditions during fURS procedures. Additionally, the rate of intraoperative complications was lower in the EasyFlex group.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hepatitis C virus and overactive bladder: a cross-sectional study based on the 2013-2018 NHANES.","authors":"Yiming Ding, Tonglei Zhao, Jie Ji, Zejun Wang, Dakun Zhang, Zhicheng Ye, Ming Chen, Weipu Mao, Jianping Wu","doi":"10.1186/s12894-026-02170-w","DOIUrl":"10.1186/s12894-026-02170-w","url":null,"abstract":"<p><strong>Backgrounds: </strong>Overactive bladder (OAB) is a common urological disorder with an incompletely understood pathogenesis that markedly impacts patients' quality of life, and hepatitis C virus (HCV) infection is associated with systemic inflammation and extrahepatic complications, with their potential association remaining understudied. This study thus aims to investigate the association between HCV and OAB in adults. This study aims to investigate the association between hepatitis C virus (HCV) and overactive bladder (OAB) in adults.</p><p><strong>Methods: </strong>This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2018. Logistic regression analysis, subgroup analysis, and interaction tests were employed to assess the association between HCV and OAB. Additionally, propensity score matching (PSM), inverse probability weighting (IPTW), and overlap weighting (OW) were employed to control for confounding factors. E-value analysis was conducted to assess the robustness of results against unmeasured confounders, while sensitivity and specificity analyses evaluated the predictive performance of HCV for OAB.</p><p><strong>Results: </strong>This study included 14,012 patients aged ≥ 20 years. Logistic regression analysis demonstrated an association between HCV and OAB (OR = 2.06, 95% CI 1.46-2.90, p < 0.001). Subgroup analyses and interaction tests confirmed that the relationship between HCV and OAB remained consistent across all subgroups (all interaction P values > 0.05). After PSM, IPTW, and OW analyses, the association between the two remained significant; E-value analysis demonstrated strong robustness to unmeasured confounders; Sensitivity and specificity results indicate that HCV has predictive value for OAB.</p><p><strong>Conclusions: </strong>The findings of this study indicate that there is a significant correlation between HCV and OAB.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}