BMC Urology最新文献

{"title":"Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma.","authors":"Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen","doi":"10.1186/s12894-025-01694-x","DOIUrl":"10.1186/s12894-025-01694-x","url":null,"abstract":"<p><strong>Background: </strong>Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. However, its significance in ccRCC has not yet been explored.</p><p><strong>Methods: </strong>We utilized external datasets and bioinformatics analyses to investigate the significance of DBF4 in ccRCC. We analysed its expression patterns, prognostic and diagnostic value, and potential mechanisms. We subsequently validated our findings through an immunohistochemistry (IHC) assay of ccRCC clinical samples. We further investigated the impact of DBF4 on the progression of ccRCC cells. Various assays, including assessments of cell proliferation, apoptosis, the cell cycle, cell migration and invasion, and colony formation, and xenograft tumor models were subsequently performed following to the knockdown of DBF4 expression via shRNA.</p><p><strong>Results: </strong>Bioinformatics analyses revealed that DBF4 is significantly overexpressed in ccRCC tissues compared with adjacent normal tissues. This overexpression was confirmed by IHC analysis of 75 pairs of clinical ccRCC tumor and adjacent tissues. Kaplan-Meier analysis revealed that high DBF4 expression was associated with a significantly lower five-year overall survival rate. Moreover, DBF4 expression was identified as an independent risk factor in multivariate Cox regression analysis. GO and KEGG pathway enrichment analyses revealed a substantial enrichment of terms associated with cell division, whereas gene set enrichment analysis (GSEA) revealed correlations between increased DBF4 expression and the activation of cell cycle-related pathways. Subsequent in vitro and in vivo experiments demonstrated that DBF4 knockdown in ccRCC cells not only suppressed proliferation and migration in vitro but also significantly inhibited tumor growth in xenograft mice by arresting the cell cycle at the G1/G0 phase, which was mediated by the inhibition of MCM2 phosphorylation and cyclin D1 and CDK4 expression.</p><p><strong>Conclusion: </strong>The current study revealed that DBF4 overexpression is a significant factor associated with malignant features and poor prognosis in patients with ccRCC. Therefore, it was proposed that DBF4 could serve as a novel potential prognostic biomarker and molecular target for ccRCC.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"8"},"PeriodicalIF":1.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"prostate-pelvic syndrome\" theory used in patients with type-III prostatitis and its correlation with prostate volume.","authors":"Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang","doi":"10.1186/s12894-025-01689-8","DOIUrl":"10.1186/s12894-025-01689-8","url":null,"abstract":"<p><strong>Background: </strong>Type-III prostatitis is the most common prostate disease in adult males below 40 years old. The actual operation of its diagnosis process is cumbersome. Recently, a group of top Chinese urologists have proposed the theory of \"prostate-pelvic syndrome (PPS)\" and suggested using it to replace the traditional term for type-III prostatitis. However, the practical application effectiveness of PPS theory in clinical practice is still unclear.</p><p><strong>Objective: </strong>The aims of this study were to verify the clinical outcome of PPS theory in diagnosing the adult patients with type-III prostatitis below 40 years old and analyze the related factors for the main symptoms of PPS in adult males below 40 years old, providing references for the prevention and treatment of PPS in young adult males.</p><p><strong>Methods: </strong>The clinical medical records of 548 adult outpatients with type-III prostatitis under 40 years old between August 2018 and May 2023 were retrospectively analyzed. The patients were diagnosed retrospectively again by using PPS diagnostic criteria in this retrospective cohort study. Subsequently, the age, disease duration, prostate volume (PV), PV ≥ 20 mL detection rate and other related indicators among different symptom groups were analyzed by univariate analysis. The correlation between different symptoms of PPS patients and PV as well as disease duration was analyzed by correlation analysis. Additionally, the related factors for different main symptoms of PPS patients were analyzed by multivariate analysis.</p><p><strong>Results: </strong>Of the 548 patients, 229 patients had lower urinary tract symptoms, 159 patients had pelvic pain symptoms, and 160 patients had lower urinary tract and pelvic pain symptoms, respectively corresponding to those with voiding symptoms (VS), pain symptoms (PS), and voiding + pain symptoms (VS + PS) defined according to the concept of PPS. There were significant differences in PV and disease duration among the three main symptoms groups of PPS. PV in the VS group was larger than that in the PS group. Spearman correlation analysis showed that VS was positively correlated with PV and disease duration, while four secondary symptoms (including sexual dysfunction, psychosocial symptoms, reproductive dysfunction and other symptoms) were not related to PV. The proportion of VS patients in the PV ≥ 20 mL group was higher than that in the PV < 20 mL group. Multivariate logistic analysis showed that PV and disease duration were independent related factors for VS in adult PPS patients below 40 years old.</p><p><strong>Conclusions: </strong>Type-III prostatitis in Chinese adult males below 40 years old can be diagnosed and treated with PPS. PV and disease duration were independent related factors for VS in Chinese adult PPS patients below 40 years old. The risk of VS in PPS patients with PV ≥ 20 mL was 5.348 times as long as that in PPS patients with PV < 20 mL.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"9"},"PeriodicalIF":1.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS.","authors":"Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu","doi":"10.1186/s12894-024-01686-3","DOIUrl":"10.1186/s12894-024-01686-3","url":null,"abstract":"<p><strong>Background: </strong>In male patients, benign prostate hyperplasia (BPH) and overactive bladder (OAB) secondary to BPH are the primary causes of Lower Urinary Tract Symptoms (LUTS). Recent clinical studies have reported an increased risk of LUTS, particularly severe LUTS conditions, in male asthmatic patients. However, the potential link and mechanism remain unclear. In this study, we investigated the structural and molecular characteristics of the prostate, and the structural and functional characteristics of the bladder in an asthma rat model.</p><p><strong>Methods: </strong>An asthma model was induced in rats through the intraperitoneal injection of ovalbumin. Prostate and bladder tissue structure was examined with Hematoxylin and Eosin (H&E) and Masson's trichrome (MT) staining, respectively. Prostatic smooth muscle contraction-related and synthesis-related protein levels were assessed using western blotting. Detrusor contractions were examined in an organ bath.</p><p><strong>Results: </strong>Prostate epithelial thickness was significantly increased in asthmatic rats, accompanied by changes in molecular markers, including increased expression of desmin and tropomyosin and decreased expression of vimentin in the prostate tissue. The bladder wall structure and bladder weight were similar in both the asthma and control groups. Acetylcholine induced concentration-dependent bladder smooth muscle contractions, which were significantly enhanced in strips from asthmatic rats, however, acetyl-β-methylcholine and carbachol induced concentration-dependent bladder smooth muscle contractions were similar in both groups.</p><p><strong>Conclusions: </strong>Our findings suggest a potential association between asthma and LUTS, with asthma possibly contributing to organ-specific changes, including prostate enlargement and increased smooth muscle contraction in the prostate and bladder. These results provide evidence for a biological connection between asthma and LUTS, laying a promising foundation for exploring new therapeutic strategies to manage LUTS in patients with asthma.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"7"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital urethral diverticulum with a large stone in a 16-year-old male: a case report.","authors":"Hazem Arab, Yousef Alsaffaf, Ahmed Aldolly, Mohammad Shehadeh","doi":"10.1186/s12894-025-01692-z","DOIUrl":"10.1186/s12894-025-01692-z","url":null,"abstract":"<p><strong>Background: </strong>Urethral diverticulum is a sac-like dilation that extends from the urethral lumen and is connected to it. It can either be congenital or acquired, with the latter being more common. The development of calculi is rare in such patients. Management is tailored based on the patient's symptoms and findings from investigations.</p><p><strong>Case presentation: </strong>A 16-year-old African male presented with recurrent urinary tract infections and a burning sensation during urination. He was diagnosed with a congenital Urethral diverticulum in the bulbar urethral containing a large stone based on the findings of echography and retrograde urethrogram. He underwent urethral diverticulectomy and stone removal, and was discharged without any complications.</p><p><strong>Conclusion: </strong>This case illustrated the uncommon presentation of congenital Urethral diverticulum with a large calculus. The cause of congenital urethral diverticula is unknown, with multiple theories proposed. The reason behind the development of such a large stone is most likely due to insufficient medical services and delayed diagnosis in the patient's environment.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"6"},"PeriodicalIF":1.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the characteristics of detrusor after contraction in females with pure urodynamic stress incontinence.","authors":"Xiao Zeng, Hong Shen, Deyi Luo, Tao Jin","doi":"10.1186/s12894-025-01691-0","DOIUrl":"10.1186/s12894-025-01691-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate detrusor after contraction (DAC) characteristics in females with pure urodynamic stress incontinence (USI).</p><p><strong>Methods: </strong>We examined the urodynamics database from our urodynamic study center. Urodynamic data from pure USI cases with and without DAC were compared. DAC was categorized based on morphological features, and urodynamic parameters in different subgroups were analyzed.</p><p><strong>Results: </strong>A total of 61 female pure USI patients met all the study requirements. Among them, there were 27 cases of pure USI with DAC and 34 cases of pure USI without DAC. The incidence of pure USI with DAC in the overall female sample was 2.5%.Significant differences were observed in Q_max between pure USI with DAC and pure USI without DAC (20.1 ± 7.2 vs. 13.0 ± 6.8, p = 0.00), as well as in Pdet_qmax (24.3 ± 15.1 vs. 16.3 ± 9.8, p = 0.02). Comparing parameters among the three subtypes of DAC revealed statistical differences in uroflow time: Type 1 DAC vs. Type 2 DAC vs. Type 3 DAC [21(20,22.5) vs. 22(16,27) vs. 30(26.8,30.8), p = 0.02], and in the maximum DAC contraction amplitude [64(46.5,107) vs. 39(25.5,48) vs. 45.5(24,74.8), p = 0.03]. Additionally, DAC was categorized into three subgroups: Type 1, Type 2, and Type 3.</p><p><strong>Conclusions: </strong>This study offers an initial exploration of morphological and mathematical aspects of DAC in urodynamics involving females with pure USI. The findings also suggest DAC may serve as a potential new indictor of bladder function in females with pure USI.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"5"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder mucosal smoothness predicts early recovery of urinary continence after laparoscopic radical prostatectomy.","authors":"Le Yu, Ye Yan, Hongling Chu, Shaohui Deng, Jianfei Ye, Guoliang Wang, Yi Huang, Fan Zhang, Shudong Zhang","doi":"10.1186/s12894-024-01682-7","DOIUrl":"10.1186/s12894-024-01682-7","url":null,"abstract":"<p><strong>Background: </strong>To propose the bladder mucosal smoothness (BMS) grade and validate a predictive model including MRI parameters preoperatively that can evaluate the early recovery of urinary continence (UC) after laparoscopic radical prostatectomy (LRP).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 203 patients (83 patients experienced UI at the three-month follow-up) who underwent LRP in our medical center and were diagnosed with prostate cancer (PCa) from June 2016 to March 2020. Patients' clinicopathological data were collected. Prostate volume (PV), membranous urethra length (MUL), intravesical prostatic protrusion length (IPPL), and BMS grade were measured by MRI. The total sample was randomly divided into a training set (n = 142) and a validation set (n = 61). A model was developed to predict the risk of urinary incontinence (UI) at three months after LRP.</p><p><strong>Results: </strong>Age group, clinical T stage group, BMS grade group, PV group, IPPL group, and MUL group differed significantly between patients in the UI group and the UC group (all P values < 0.05). Multivariate analysis identified 3 MRI-related predictors selected for the prediction model: BMS grade (1 odds ratio [OR] 0.17, 95% CI 0.11-0.66; P value = 0.024) (2 + 3 OR 0.17, 95% CI 0.04-0.66; P value = 0.011), IPPL (> 5 mm OR 0.17, 95% CI 0.1-0.64; P = 0.004), and MUL (≥ 14 mm OR 6.41, 95% CI 2.72-15.09; P value < 0.001). The model achieved a highest area under the curve of 0.900 in the training set and the validation set. The sensitivity and specificity of the prediction model were 0.800 and 0.816.</p><p><strong>Conclusion: </strong>Our study confirmed that patients with lower BMS grade are associated with early recovery of urinary continence after LRP. A prediction model was developed and validated to evaluate the early recovery of urinary continence after LRP.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"4"},"PeriodicalIF":1.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between albumin-globulin ratio and prostate-specific antigen: a cross-sectional study based on NHANES 2003-2010.","authors":"Simeng Gao, Shaojie Li, Baofang Wu, Jiayin Wang, Sijuan Ding, Zhaohui Tang","doi":"10.1186/s12894-024-01687-2","DOIUrl":"https://doi.org/10.1186/s12894-024-01687-2","url":null,"abstract":"<p><strong>Purpose: </strong>The albumin-globulin ratio (AGR) influences the development of prostate cancer; however, the relationship between AGR and prostate-specific antigen (PSA) has not been reported.</p><p><strong>Methods: </strong>This cross-sectional investigation used comprehensive AGR versus PSA data from men with 40 years of age and older, who participated in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2010, spanning 4 investigation cycles, as only these cycles contained complete PSA data. To evaluate the nonlinear relationship between the ARG and PSA level, a regression utilizing smoothed curve fitting (penalized spline approach) and a generalized additive model (GAM) were employed. A two-segment linear regression model was used to conduct threshold effect evaluations. Lastly, subgroup analyses were carried out along with interaction tests.</p><p><strong>Results: </strong>This study included 5,376 subjects, whose total serum PSA (mean ± standard deviation) was 1.83 ± 3.34, and its level decreased roughly with increasing quartiles of AGR. In the fully-adjusted model, AGR was negatively correlated with the likelihood of PSA, and this relationship persisted across subgroups (trend > 0.05). The PSA was characterized by an \"L\"-shaped curve with an inflection point. On the left side of the inflection point (K = 1.32), there was a negative relationship between AGR and PSA.</p><p><strong>Conclusion: </strong>In the United States, among men over 40 years of age without prostate diseases, AGR demonstrated a nonlinear relationship with PSA, negatively correlating when AGR was below 1.32.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"3"},"PeriodicalIF":1.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ratio of COL2A1:COL1A1 in dartos tissue patients with hypospadias.","authors":"Prahara Yuri, Hotman Christinus, Zico Yusuf Alfarizi, Medina Ndoye","doi":"10.1186/s12894-024-01688-1","DOIUrl":"https://doi.org/10.1186/s12894-024-01688-1","url":null,"abstract":"<p><strong>Background: </strong>The inelasticity of dartos tissue and the regulation of collagen expression are significant factors in the pathophysiology of chordee associated with hypospadias. While the COL2A1:COL1A1 ratio is recognised as a measure of cell differentiation, there is yet to be a study specifically examining this ratio in hypospadias. The aim of this study was to determine the COL2A1:COL1A1 ratio.</p><p><strong>Methods: </strong>We collected 55 samples of dartos tissue, comprising 35 from patients with hypospadias procured from urethroplasty procedures and 20 from patients with phimosis collected during circumcision without any lichen cases at our institution. The gene expression levels of COL1A1 and COL2A1 in the dartos tissue were analyzed using reverse-transcriptase polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>Based on the type of penile abnormality, the expression levels of COL1A1 and COL2A1 measured by qPCR were downregulated in hypospadias, with value of 0.83 (0.38-2.53) and 0.43 (0.10-5.66), respectively, compared to phimosis, which had levels of 1.85 (1.24-4.61) and 0.94 (0.26-2.47) (p < 0.001). The expression levels of COL1A1 and COL2A1 were also significantly downregulated among mild, moderate, severe penile curvature, and control groups (p < 0.001 and p = 0.02). However, the COL2A1:COL1A1 ratio did not show statistically significant differences based on penile abnormalities and curvature (p > 0.05).</p><p><strong>Conclusion: </strong>The expression levels of COL1A1 and COL2A1 are significantly downregulated in patients with hypospadias and ventral curvature when compared to those in the phimosis group. However, the COL2A1:COL1A1 ratio was not significant.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"2"},"PeriodicalIF":1.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous nephroscopy versus flexible ureteroscopy in the treatment of calyceal diverticulum calculi: a meta-analysis.","authors":"Conglei Hu, Rui Ma, Yongxiang Shao, Zilong Liang, Meng Cheng, Haofeng Pang, Liping Yao, Fei Liu","doi":"10.1186/s12894-024-01655-w","DOIUrl":"10.1186/s12894-024-01655-w","url":null,"abstract":"<p><strong>Background: </strong>There is still controversy about the best minimally invasive surgical method for the treatment of calyceal diverticulum calculi. We conducted meta-analysis to evaluate the effectiveness and safety of PCNL and FURL in the treatment of calyceal diverticulum calculi.</p><p><strong>Methods: </strong>We searched Pubmed, Cochrane Library, Web of Science, Embase, Clinical trial platform, CNKI, VIP until April 2024. We utilized the Newcastle-Ottawa Scale (NOS, 0 to 9 stars) to assess the quality of the included literature.</p><p><strong>Results: </strong>Totally 15 high-quality studies with 755 patients were included in the meta-analysis. Meta-analysis showed that FURL group was better than PCNL group in blood loss [SMD = 1.713, 95%CI:(0.858, 2.568), Z = 3.928, P = 0.000] and hospital stay [SMD = 2.611, 95%CI: (1.726, 3.496), Z = 5.784, P = 0.000], there was no significant difference in operating time [SMD = 0.079, 95%CI:(-0.43, 0.589), Z = 0.306, P = 0.760], complication rate [OR = 1.793,95%CI: (0.952,2.602), Z = 1.586, P = 0.113], stone-free rate [OR = 1.339, 95%CI: (0.576, 3.112), Z = 0.678, P = 0.497] and symptom-free rate [OR = 3.826,95%CI: (0.561,10.238), Z = 0.966, P = 0.334] as well.</p><p><strong>Conclusion: </strong>Whether FURL is indeed superior to PCNL in safety, whether FURL's efficacy is really close to PCNL, and whether FURL can surpass PCNL as the first choice for the treatment of renal diverticulum stones in the future need to be further verified by multi-center, large-sample and high-quality studies.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience.","authors":"Xing Huang, Chupeng Sun, Peng Zhang, Lei Wang","doi":"10.1186/s12894-024-01674-7","DOIUrl":"10.1186/s12894-024-01674-7","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs) alone or in combination with standard chemotherapy for advanced urothelial carcinoma (UC) have been tested as first-line treatment in clinical trials. This study aimed to evaluate the clinical outcomes of programmed cell death 1 (PD-1) inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic UC in a real world clinical care setting, and sought to identify prognostic factors for overall survival (OS).</p><p><strong>Methods: </strong>A retrospective, real-world study involving 35 locally advanced or metastatic UC patients treated with PD-1 inhibitor alone or in combination with chemotherapy was conducted. Kaplan-Meier curves were used to assess progression-free survival (PFS) and OS. A Cox regression analysis was conducted to explore the association of baseline variables with OS.</p><p><strong>Results: </strong>In our cohort of 35 patients, 7 patients were treated with PD-1 inhibitor alone and 28 with PD-1 inhibitor plus platinum-based chemotherapy. The median OS was 16.0 months (95% CI: 11.9-20.1), and median PFS was 12.0 months (95% CI: 8.6-15.4) for all patients. PD-1 inhibitor combined with chemotherapy was associated with better PFS than PD-1 inhibitor monotherapy (HR: 0.19, p = 0.018). Treatment-related adverse events (AEs) of any grade occurred in 5 (71.4%) patients who received PD-1 inhibitor and 24 (85.7%) patients who received PD-1 inhibitor plus chemotherapy. Eastern Cooperative Oncology Group (ECOG) performance status (PS) and neutrophil-lymphocyte ratio (NLR) were identified as prognostic factors.</p><p><strong>Conclusion: </strong>This study suggested that patients with locally advanced or metastatic UC could benefit from PD-1 inhibitor alone or combined with chemotherapy in daily clinical practice. ECOG PS and NLR can be used for prognostication of survival.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"289"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}