BMC Urology最新文献

{"title":"Establishment and validation of a predictive model for renal injury caused by unilateral upper urinary tract stone obstruction based on dynamic renal scintigraphy.","authors":"Ming-Yi Zang, Yu-Qiang Zhang, Xiao-Bin Xu, Jun-Jie Zhang, Yan Zhao, Cong-Hui Han","doi":"10.1186/s12894-026-02067-8","DOIUrl":"10.1186/s12894-026-02067-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and validate a predictive model for assessing the risk of renal impairment due to unilateral upper urinary tract stone obstruction, leveraging easily accessible clinical indicators to overcome the limitations of traditional renal function markers and the impracticality of Dynamic Renal Scintigraphy (DRS) in routine clinical practice.</p><p><strong>Methods: </strong>A multicenter, retrospective cohort study was conducted with 370 patients who had unilateral upper urinary tract stones and underwent DRS. Patients were split into training (n = 259) and validation (n = 111) groups. Initial screening of 16 candidate variables led to the identification of five key predictors via LASSO regression: age, asymptomatic status, maximum stone cross-sectional area, urine white blood cell count, and hydronephrosis Society for Fetal Urology (SFU) grade. A nomogram was developed to visualize the model, and its performance was assessed using ROC curves, calibration plots, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The model demonstrated robust discrimination, with AUC values of 0.742 (95% CI: 0.61-0.82) in the training set and 0.793 (95% CI: 0.675-0.911) in the validation set. Calibration curves confirmed high accuracy, and DCA highlighted significant clinical value. Older age, asymptomatic presentation, larger stone size, elevated urine white blood cells, and higher SFU grade were independently linked to a higher risk of renal impairment.</p><p><strong>Conclusion: </strong>The proposed nomogram offers a practical, non-invasive method for early identification of patients at high risk of renal impairment from unilateral upper urinary tract stone obstruction, enabling timely intervention and optimized resource utilization. This model is particularly beneficial in primary care settings where DRS is unavailable, providing a cost-effective alternative to mitigate irreversible renal damage.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of machine learning prediction models for postoperative outcomes in adult male circumcision.","authors":"Leonid Shpaner, Giuseppe Saitta","doi":"10.1186/s12894-026-02072-x","DOIUrl":"10.1186/s12894-026-02072-x","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of safety reporting in interventional trials of benign prostatic hyperplasia: a registry-publication comparison study.","authors":"Malek Itani, Tanner Livsey, Kellen Keefer, Ahmed Elghzali, Ryan Sherry, Tag Harris, Daniel Archer, Alicia Ito Ford, Matt Vassar","doi":"10.1186/s12894-026-02077-6","DOIUrl":"10.1186/s12894-026-02077-6","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effectiveness of methenamine hippurate in preventing urinary tract infections: an updated systematic review, meta-analysis and trial sequential analysis of randomized controlled trials.","authors":"Giovanna Cardoso De Oliveira, Nathalie Cordeiro Hobaica, Breno Cordeiro Porto, Carlo Camargo Passerotti, Rodrigo Afonso Da Silva Sardenberg, Jose Pinhata Otoch, Jose Arnaldo Shiomi Da Cruz","doi":"10.1186/s12894-025-02036-7","DOIUrl":"10.1186/s12894-025-02036-7","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"26 1","pages":"37"},"PeriodicalIF":1.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical varicocelectomy versus laparoscopic surgery versus embolization for varicocele: a retrospective cost-effectiveness analysis.","authors":"Jianjia Wang, He Jiang, Jianhua Lan","doi":"10.1186/s12894-026-02076-7","DOIUrl":"10.1186/s12894-026-02076-7","url":null,"abstract":"<p><strong>Background: </strong>Varicocele is one of the most common causes of male infertility. Although multiple surgical and interventional methods are available, their cost-effectiveness remains insufficiently studied. This study aimed to compare short-term clinical outcomes and cost-effectiveness of microsurgical and laparoscopic varicocelectomy, reporting embolization outcomes as exploratory data owing to the limited number of cases.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 113 patients with varicocele who were admitted to our hospital between June 2022 and May 2025. Based on the surgical approach, patients were categorized into three groups: microsurgical (n = 42), embolization (n = 8), and laparoscopic (n = 63). Owing to the small size of the embolization cohort, primary comparative and cost-effectiveness analyses were performed for the microsurgical and laparoscopic groups, while embolization outcomes were reported descriptively. Preoperative and postoperative measures, including sperm concentration, percentage of forward-moving spermatozoa (PR%), maximum diameter of the spermatic vein, surgical cost, and postoperative complications, were compared and analyzed. All procedures were performed by senior urologists experienced in varicocele repair, and postoperative complications were recorded. A cost-effectiveness analysis was performed by calculating the cost-effectiveness ratio (CER) and incremental CER based on hospitalization costs and improvements in semen parameters.</p><p><strong>Results: </strong>All 113 patients successfully completed surgical treatment. Intra-group comparisons showed that all three surgical approaches led to significant postoperative improvements compared with the preoperative period (P < 0.05). Inter-group comparisons indicated that the improvement in PR% was significantly greater in the microsurgical group than in the laparoscopy group (P < 0.05). Cost-effectiveness analysis revealed that microsurgery yielded the lowest CERs for sperm concentration improvement (CER: 410.13) and PR% improvement (CER: 220.78), with incremental analysis demonstrating that microsurgery was superior to laparoscopic surgery.</p><p><strong>Conclusions: </strong>In this single-center retrospective cohort, microsurgical varicocelectomy was associated with superior short-term improvement in PR% and more favorable cost-effectiveness compared with laparoscopic varicocelectomy. Embolization outcomes were exploratory because of the limited sample size and should be interpreted with caution. Further multicenter studies with larger embolization cohorts and longer follow-up are warranted.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcomes after single-stage spiral preputial graft urethroplasty for panurethral strictures: a single-centre prospective study.","authors":"Saurabh Thakkar, Pankaj Joshi, Shreyas Bhadranavar, Jimena Navarro, Parth Barot, Pawan Kandhari, Sanjay Kulkarni","doi":"10.1186/s12894-026-02070-z","DOIUrl":"10.1186/s12894-026-02070-z","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified water vapor thermal therapy for large-volume benign prostatic hyperplasia.","authors":"Qun Lu, Guanchen Zhu, Jun Liu, Haifeng Huang, Fan Zhang, Xuefeng Qiu, Linfeng Xu, Hongqian Guo","doi":"10.1186/s12894-026-02050-3","DOIUrl":"10.1186/s12894-026-02050-3","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the efficacy and safety of modified water vapor thermal therapy for large-volume benign prostatic hyperplasia (BPH).</p><p><strong>Methods: </strong>This prospective study enrolled 196 consecutive patients with prostate volume ≥ 80 mL who underwent modified water vapor thermal therapy at our institution between October 2023 and September 2024. All procedures were performed using the Rezum system.</p><p><strong>Results: </strong>The procedures were successfully completed in all 196 patients with a median prostate volume of 96 mL. The IPSS decreased from a preoperative mean of 21.2 ± 3.9 to 11.7 ± 3.4 at 3 months, and further improving to 10.8 ± 3.8 at 1 year. Median prostate volume reduced from 96 mL to 60 mL. The QoL score improved from 4.3 ± 0.9 to 1.7 ± 1.1, and Qmax increased from 8.3 ± 2.3 mL/s to 15.7 ± 3.5 mL/s at 3 months. All observed improvements were statistically significant compared to baseline (P < 0.01). The IIEF-5 score increased from 11.0 ± 3.6 to 14.1 ± 5.4 at 1 year, indicating a statistically significant improvement in erectile function (P < 0.05). The incidence of retrograde ejaculation was 3.1%. Only one patient (0.5%) required surgical retreatment during the follow-up period.</p><p><strong>Conclusions: </strong>Modified water vapor thermal therapy demonstrates favorable efficacy and safety in the treatment of large-volume BPH. It is associated with significant symptom relief, functional improvement, and minimal complications.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between polyunsaturated fatty acid intake and proteinuria in the US adult population: a study from the NHANES database.","authors":"Hao Zhang, Qi Yu Zeng, Ping Zhang","doi":"10.1186/s12894-026-02074-9","DOIUrl":"10.1186/s12894-026-02074-9","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal management of primary mixed neuroendocrine prostate cancer with bone flare phenomenon: a rare case report and therapeutic insights.","authors":"Lijing Xu, Jialin Wang","doi":"10.1186/s12894-026-02064-x","DOIUrl":"10.1186/s12894-026-02064-x","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Micro-hole Zone Technology as a new era in urinary drainage: a narrative review from bench to bedside.","authors":"Michael Kennelly, Susanne Vahr Lauridsen, Nikesh Thiruchelvam, Andrei Krassioukov, Charalampos Konstantinidis, Emmanuel Chartier Kastler, Rikke Vaabengaard, Malene Hornbak Landauro, Marcio Augusto Averbeck","doi":"10.1186/s12894-026-02063-y","DOIUrl":"10.1186/s12894-026-02063-y","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}