BMC Urology最新文献

{"title":"Examining pessary use and satisfaction in managing pelvic organ prolapse: results from a cross-sectional multicentre patient survey.","authors":"Minhal Mussawar, Sahar Khademioore, Astha Chandra, Mehrshad Hanafimosalman, Garson Chan","doi":"10.1186/s12894-024-01614-5","DOIUrl":"https://doi.org/10.1186/s12894-024-01614-5","url":null,"abstract":"<p><strong>Background: </strong>Vaginal pessaries are a common method of managing pelvic organ prolapse (POP), as well as different types of urinary incontinence, allowing patients to successfully improve overall quality of life. Yet despite their positive attributes, there are several reasons why patients may choose to discontinue using pessaries and proceed with surgery to treat their condition instead. This study aimed to explore patients' experiences of pessary use in treating POP.</p><p><strong>Methods: </strong>Participants completed an online survey regarding pessary use and ideal characteristics of a pessary. Participants were recruited from social media advertisements, online support groups for women's health-related conditions, and pelvic floor clinics.</p><p><strong>Results: </strong>A total of 100 participants were recruited, of which 77 fully completed the survey. The biggest age group of participants was above 65 years, with 48.1% of participants falling into this category, followed by 35-44 years accounting for 20.8% of respondents. Respondents cited pelvic pain (35.2%), excess vaginal discharge and odor (32.4%), as well as difficulty with pessary placement as the most common issues related to pessary use (41.9%). Easy insertion, removal (81.8%), and relief from side effects (81.8%) were the most commonly reported ideal characteristics for pessary use.</p><p><strong>Conclusion: </strong>Patients had important concerns with pessary use and a high number either stopped or were considering stopping even when it improved their POP. Whilst pessaries can help in the management of POP, further improvement is warranted to increase pessary use, such as through the development of user-friendly designs, or applicators to aid with fitting.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"278"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-contrast CT attenuation value of renal papilla is a novel predictor of recurrence in kidney stone disease.","authors":"Yasuo Kohjimoto, Shimpei Yamashita, Yuya Iwahashi, Ryusuke Deguchi, Takahito Wakamiya, Isao Hara","doi":"10.1186/s12894-024-01657-8","DOIUrl":"https://doi.org/10.1186/s12894-024-01657-8","url":null,"abstract":"<p><p>In calcium stone formers, most stones grow attached to Randall's plaque, which can be identified by measuring the computed tomography (CT) attenuation value of renal papilla. We hypothesized that the CT attenuation value of renal papilla can predict the severity (recurrent or multiple stone former) and recurrence of the stone disease. We retrospectively reviewed the charts of 180 calcium oxalate stone formers who underwent non-contrast CT and 24-hour urine chemistry in our hospital between September 2012 and November 2021. Two observers independently measured the Hounsfield unit (HU) of the renal papilla and classified the patients into the low-HU and the high-HU value groups according to the median value (38.9 HU). The proportion of recurrent and multiple stone formers were similar between the low-HU group and the high-HU group (70.0% vs. 65.6%, 71.1% vs. 74.2%, respectively). There were also no significant differences in urinary volume, urinary excretions of each constituent, or AP(CaOx) index between the two groups. On the other hand, the recurrence rate in the high-HU value group (0.10 events/person/year) was significantly higher than that in the low-HU value group (0 events/person/year, p = 0.03). Multivariate analysis revealed that high-HU value was an independent predictor of stone recurrence (OR 1.90, 95% CI 1.00-3.64, p = 0.04) as well as medical prophylaxis. The results of this study suggest that HU value of renal papilla is a useful predictor of recurrence of stone disease.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"279"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrauterine device (IUD) migration completely into the abdominal cavity and half into the bladder to form a stone: a case report and mini-review.","authors":"Fangqiu Yu, Mo Chen, Hongliang Cao, Gang Yang, Weigang Wang, Yuantao Wang","doi":"10.1186/s12894-024-01676-5","DOIUrl":"https://doi.org/10.1186/s12894-024-01676-5","url":null,"abstract":"<p><p>The intrauterine device (IUD) is an important and highly effective means of contraception. Migration of the IUD, post implantation, out of the uterus is an infrequent complication, and its subsequent migration into the urinary bladder with formation of secondary bladder calculi, is even more infrequently reported. The authors report a 51 year old woman who had had her last child delivered via cesarean section 16 years ago. She underwent an IUD insertion in the next few months but was subsequently lost to follow up. Before detection of the ectopic state of the IUD she complained of dysuria and dyspareunia for two weeks. Clinically detected suprapubic discomfort on palpation. After a series of imaging studies and cystoscopy, the presence of an IUD stump with stones attached to it in the patient's bladder were confirmed. Cystoscopy followed by laser lithotripsy of the calculus was performed, as the first step in the treatment. After failure to remove the IUD cystoscopically, further cystotomy was made, however one side end of the cap structure of the IUD could not be located, necessitating abdominal exploration and irrigation till retrieval in totality. The patient made an uneventful recovery.The case report emphasizes the importance of excluding uncommon etiolgies like ectopic IUDs as a cause of immobile adherent bladder calculi in women. Complete removal necessitates good preoperative knowledge of the type of IUD, as structural degradation might lead to separation of its components. An adequate consent for a possible exploration of the abdomen in case of a missing component should also be taken.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"280"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corpus cavernosum and tunica albuginea reconstruction by tissue engineering: towards functional erectile structures regeneration.","authors":"Yilong Guo, Ning Ma, Yangqun Li, Zhe Yang, Sen Chen, Pingping Liu, Qianqian Gao, Sisi Luo, Quan Sun","doi":"10.1186/s12894-024-01605-6","DOIUrl":"https://doi.org/10.1186/s12894-024-01605-6","url":null,"abstract":"<p><strong>Background: </strong>Current treatments for penile erectile structures reconstruction are limited and remain a great challenge in clinical practice. Tissue engineering techniques using different seed cells and scaffolds to construct a neo-tissue open promising avenues for penile erectile structures repair and replacement and show great promise in the restoration of: structure, mechanical property, and function which matches the original tissue.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted by accessing the NCBI PubMed, Cochrane, and Google Scholar databases from January 1, 1990, to January, 1, 2022 using the search terms \"Tissue engineering, Corpus cavernosum (CC), Tunica albuginea (TA), Acellular Matrix, Penile Reconstruction\". Articles were screened and assessed by two independent reviewers to determine whether those met the inclusion criteria, and a total of 19 articles were being selected and included in the data analysis.</p><p><strong>Results: </strong>Tissue engineered cell-seeded scaffold can reconstruct a similar structure to native TA and CC and showed good histocompatibility with no immunological rejection. The results of the evaluation of morphological feature, intracavernosal pressure, and erectile-related nitric oxide (NO) expression were strongly proofs that the tissue engineered graft can significantly improve the penile erectile and ejaculatory function. In addition, increasing the purity of seed cells, improving the mechanical properties of the scaffold, providing appropriate induction for stem cells, and optimizing cell delivery systems are potential approaches to improve reconstructive outcomes. Currently, a larger animal model, comparable in size to the human penis, is needed to test the feasibility of the engineered grafts.</p><p><strong>Conclusion: </strong>Our review summarized the research in tissue engineering of CC and TA. It showed great promise in reconstructing the functional structures and restoring the erection and ejaculatory function. With continuous advancement in the field, tissue-engineered penile erectile structures hold substantial potential to enhance clinical outcomes for patients.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"282"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum and the management of glanular-preputial adhesions after ritual male circumcision.","authors":"Mohamed A Baky Fahmy, Amr Hussein Elsayed Mohamed, Mohamed Fawzy ElSayed Ali AbdAlla, Nour A Nour","doi":"10.1186/s12894-024-01672-9","DOIUrl":"https://doi.org/10.1186/s12894-024-01672-9","url":null,"abstract":"<p><strong>Background: </strong>Complications after male circumcision are numerous and may be presented as an adhesion between the glans penis and the preputial remnants, these adhesions may acquire different forms and troublesome the affected children.</p><p><strong>Patients and methods: </strong>This is a retrospective study of 95 consecutive children of presumed glanular-preputial adhesions referred for correction of circumcision. They were assessed and classified as having either an early preputial adhesion or a well-formed skin bridge into 2 groups; group (A) who have a simple adhesion that was resolved through a conservative preputial adhesiolysis while those in the group (B) had a well-formed skin bridge, which deserves surgical correction. Histopathology done for 30 cases from group B. All cases were followed up till resolution of the adhesion.</p><p><strong>Results: </strong>A wide diversity of the Glanular-Preputial Adhesions (GPA) was recognized with a different form ranged from a simple fibrinous adhesion which was diagnosed in 55 cases (group A), these adhesions were resolved with medical treatment, and a well-formed single or multiple skin bridges formed 3-4 months after circumcision; which were detected in 40 patients (group B) with a smegma pearls in 15, all required a surgical adhesiolysis. Mean age of patients was 3 years (6 months to 12 years). Three cases were diagnosed with penile scleroatrophic lichen balanitis.</p><p><strong>Conclusion: </strong>Glanular-Preputial Adhesions is not a rare complication after MC. It could be a simple fibrinous; which resolves with topical corticosteroid or a well-formed skin bridge which needs surgical adhesiolysis.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"283"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urology outpatient procedures by physician associates and nurse practitioners.","authors":"Roderick S Hooker, Robert E McKenna","doi":"10.1186/s12894-024-01658-7","DOIUrl":"https://doi.org/10.1186/s12894-024-01658-7","url":null,"abstract":"<p><strong>Object: </strong>Physician associates (PAs) and nurse practitioners (NPs) are distributed across 70 medical and surgical specialties. A central role is to provide outpatient care. Urology is a significant employer of PAs and NPs, but their scope of practice in the ambulatory setting needs to be better delineated.</p><p><strong>Data sources and study setting: </strong>We conducted a retrospective cohort analysis of frequently performed ambulatory urological procedures identified by the American Urological Association, drawing on Medicare Procedure Summary master files.</p><p><strong>Study design: </strong>We analyzed Part B Medicare outpatient urology procedure claims from 2014 through 2021. The analysis compared the procedural reimbursable claims filed by urologists, PAs, and NPs.</p><p><strong>Principal findings: </strong>From 2014 to 2022, urologists, PAs, and NPs filed over 35 million outpatient urology procedural claims. In 2021, ultrasound measurement of bladder capacity after voiding, endoscopic examination of the bladder and urethra, and electronic assessment of bladder emptying were the most performed procedures. The number of urologists filing claims for the 15 most common outpatient procedures decreased slightly by 0.66% between 2014 and 2021, while the number of PAs and NPs who did so increased by 109% and 156%, respectively. Although urologists performed nearly 13 times as many commonly performed outpatient procedures, the number performed by urologists declined by 15%. In contrast, the number of urologic procedures performed by PAs and NPs increased by 130% and 162%, respectively.</p><p><strong>Conclusions: </strong>This analysis of mostly older Americans receiving urological care illustrates a broadening scope of practice for PAs and NPs in this specialty. The results exemplify team-based care and the economic principle of task transfer in urology. This shift in ambulatory proceduralist roles occurred as the demand for urological care increased while the supply of urologists lagged.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"281"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between circulating miRNA-222-3p and miRNA-136-5p and the efficacy of docetaxel chemotherapy in metastatic castration-resistant prostate cancer patients.","authors":"Shuai Yuan, Xing Bi, Furhati Shayiti, Yue Niu, Peng Chen","doi":"10.1186/s12894-024-01666-7","DOIUrl":"https://doi.org/10.1186/s12894-024-01666-7","url":null,"abstract":"<p><strong>Background: </strong>Metastatic castration-resistant prostate cancer is the most dangerous stage of prostate cancer, with a high mortality rate. Docetaxel chemotherapy is one of the most effective treatment methods currently, but some patients do not respond to chemotherapy. To avoid unnecessary toxicity in non-responders, this study explores the potential of circulating microRNAs as early biomarkers of docetaxel response in patients with metastatic castration-resistant prostate cancer.</p><p><strong>Methods: </strong>PC3 cells and DU145 cells were divided into the control, NC mimics, and miRNA-136-5p-mimics groups. Cell viability was measured using the CCK-8 assay. Cell apoptosis was determined by flow cytometry. Cell migration and invasion abilities were evaluated using the Transwell assay. Real-time quantitative PCR was used to measure the miRNA levels in cells and peripheral blood of patients. The miRNA-136-5p target genes were predicted by using the PITA, TargetScan, and miRanda databases. The target genes were analyzed with KEGG pathway analysis.</p><p><strong>Results: </strong>In both PC3 and DU145 cells, the miRNA-136-5p-mimics group exhibited significantly increased cell survival rates, migration and invasion numbers, and significantly decreased apoptosis rates than the control group (p < 0.05). The miRNA-222-3p and miRNA-136-5p levels were significantly increased in docetaxel-resistant PC3 and DU145 cells (p < 0.05). The levels of circulating miRNA-222-3p and miRNA-136-5p were significantly associated with docetaxel treatment (p < 0.05). Higher levels of miRNA-222-3p were observed in non-responsive patients (p < 0.05). The area under the curve for miRNA-222-3p was 0.76 (95%CI: 0.55-0.97), indicating its effectiveness as a predictive factor for non-responsive patients to docetaxel. Patients with high expression of miRNA-34c-5p after docetaxel chemotherapy had shorter overall survival times (P < 0.05). Bioinformatics analysis identified 110 potential target genes of miRNA-136-5p. KEGG revealed that these genes were mainly distributed in three pathways. Among them, the PI3K-AKT pathway was closely related to the metastasis of prostate cancer cells.</p><p><strong>Conclusion: </strong>Our study demonstrates that miRNA-136-5p promotes the proliferation and invasion of PC3 and DU145 cells while inhibiting apoptosis. Circulating miRNA-222-3p may serve as a biomarker for early therapeutic response to docetaxel, and further clinical investigation is warranted. Additionally, miRNA-136-5p may have anti-cancer effects during docetaxel chemotherapy in metastatic castration-resistant prostate cancer.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"275"},"PeriodicalIF":1.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomonitoring in bladder cancer: a short report on stability of leukocytes and proteins in refrigerated urine samples.","authors":"Alexandra Sevko, Claudia Prevosto, Suvetha Ragavan, Sonia Domingos-Pereira, Valérie Cesson, Marc Biarnes Carrera, Laurent Derré, Livija Deban","doi":"10.1186/s12894-024-01673-8","DOIUrl":"https://doi.org/10.1186/s12894-024-01673-8","url":null,"abstract":"<p><strong>Background: </strong>Urine biomarkers are crucial for monitoring patient responses in treating urological pathologies, including non-muscle invasive bladder cancer (NMIBC). Yet, analysing urine biomarkers poses several challenges, including ensuring specimen stability during transportation and analytical processing. This prospective feasibility study aimed to investigate how urinary leukocytes and proteins are impacted by storing and refrigerating urine.</p><p><strong>Methods: </strong>Stability of leukocytes from four healthy donors (HD) spiked into urine supernatants was analyzed for up to 72 h at 4°C. Urine samples from five NMIBC patients undergoing BCG treatment were divided into two portions, followed by either immediate processing or overnight refrigeration. Urinary cell content and soluble factors were analyzed by multiparameter flow cytometry and Luminex®, respectively.</p><p><strong>Results: </strong>We confirmed the stability of healthy donor peripheral blood leukocytes spiked into cell-free urine supernatants from healthy donors or untreated bladder cancer patients for up to 72 h under refrigeration at + 5℃. Additionally, we conducted immune cell and proteomic analysis from urine samples obtained from five NMIBC patients receiving Bacillus Calmette-Guérin (BCG) therapy either processed immediately or after overnight refrigeration. We successfully demonstrated that leukocyte and protein composition remain stable in refrigerated urine from BCG-treated NMIBC for 24 h. This included granulocytes, monocytes, and T cells, as well as total protein, creatinine and 46 additional individual immune-related mediators.</p><p><strong>Conclusions: </strong>This work demonstrates the compatibility of refrigerated urine shipment from the collection sites to analytical laboratories with both immunophenotyping and proteomic analysis and establishes clear logistical benefits for numerous clinical settings focused on monitoring patient immune responses in the urine matrix.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"276"},"PeriodicalIF":1.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving one artery shortens the surgical time and does not affect the efficacy of microsurgical subinguinal varicocelectomy: preliminary findings from a retrospective study.","authors":"Xu Cao, Cheng Tian, Wei Feng, Shu-Xian Zhu, Kai Chen, Yu-Hang Zheng, Jian-Zhong Yao","doi":"10.1186/s12894-024-01670-x","DOIUrl":"https://doi.org/10.1186/s12894-024-01670-x","url":null,"abstract":"<p><strong>Background: </strong>To analyze the safety and efficacy of microsurgical subinguinal varicocelectomy(MSV) performed with and without preservation of all testicular arteries and lymphatic system.</p><p><strong>Methods: </strong>All of the 98 patients with varicocele who underwent MSV were included in the analysis. Fifty-eight male patients surgically underwent MSV with preservation of all testicular arteries and lymphatic system(Group 1). The other 40 male patients surgically underwent MSV with preservation of a single testicular artery, while the remaining vascular bundle sparing the vas deferens with its vessels was then isolated\"en bloc,\" ligated and cut(Group 2). Operative time, semen parameters and complications were then compared.</p><p><strong>Results: </strong>Mean operative time for Group 1 was significantly longer than that of Group 2(90.26 ± 21.69 min vs. 79.30 ± 19.58 min, P = 0.01). Visual analogue pain scale (VAS) decreased significantly in both groups. Group 1 experienced a decrease from a median of 5 (interquartile range, IQR: 4 ~ 6) to 1 (IQR: 0 ~ 2), P < 0.001; similarly, Group 2 saw a reduction from a median of 4 (IQR: 3 ~ 5.75) to 1 (IQR: 1 ~ 2), P < 0.001. Additionally, notable improvements were recorded in sperm count and motility in both groups at the 12-month follow-up compared to their pre-operative measurements. For Group 1, sperm count increased from a median of 35.5 × 10⁶/mL(IQR: 29 ~ 60) to 60 × 10⁶/mL(IQR: 50 ~ 74.25), and motility from 46.5% (IQR: 32 ~ 56%) to 69%(IQR: 54.5 ~ 79%), both with P < 0.001. Group 2 showed similar enhancements, with sperm count rising from a median of 31 × 10⁶/mL (IQR: 20 ~ 56.25) to 57.5 × 10⁶/mL(IQR: 51.25 ~ 73.75) and motility from 44% (IQR: 23 ~ 54.75%) to 75% (IQR: 51.25 ~ 80%), P < 0.001. The duration of postoperative hospital stay was comparable between the two groups, with both reporting a median stay of 3 days (IQR: 2-3 days, P = 0.83). No testicular atrophy and varicocele recurrence was observed in all patients. The incidence rates of hydrocele, wound infection, and orchitis and epididymitis showed no significant disparity between the two groups. Specifically, both groups each had a single incidence of hydrocele. Group 1 had one incidence of wound infection, while Group 2 had none. Orchitis and epididymitis occurred once in Group 1, but not in Group 2.</p><p><strong>Conclusion: </strong>Our study provides preliminary evidence supporting the implementation of the\"en bloc\" procedure in MSV as a potentially safe and effective option, especially for managing cases with severe adhesion.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"277"},"PeriodicalIF":1.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteome-wide Mendelian randomization and therapeutic targets for bladder cancer.","authors":"Meng-Hua Wu, Min-Heng Zhang, Xiao-Dong Hu, Hai-Xia Fan","doi":"10.1186/s12894-024-01677-4","DOIUrl":"https://doi.org/10.1186/s12894-024-01677-4","url":null,"abstract":"<p><strong>Objective: </strong>To identify therapeutic protein targets for bladder cancer (BCa) using Mendelian randomization (MR) and assess potential adverse effects of these targets.</p><p><strong>Methods: </strong>A proteome-wide MR study was conducted to determine causal relationships between plasma proteins and BCa risk. In the discovery stage, the plasma proteins (Exposure) were sourced from the R10 of Finnish database, Olink (619 samples across 2925 proteins) and SomaScan (828 samples across 7596 proteins), and Iceland database. In the replication stage, plasma proteins (Exposure) were sourced from the UK-Biobank-PPP database (54,219 participants and 2940 proteins). Summary-level data for BCa (Outcome) were obtained from the UK Biobank (UKB-SAIGE: cancer of bladder) in the discovery phase and the FinnGen consortium (FinnGen R11: cancer of bladder) in the replication phase. Colocalization and fix-effect meta-analyses were performed to validate MR findings. Finally, phenome-wide association study (Phe-WAS) was conducted to explore the side effects of druggable proteins utilizing UKB-SAIGE encompassing 783 phenotypes.</p><p><strong>Results: </strong>The MR analysis identified PSCA, LY6D, and SLURP1 as proteins with a genetic association to BCa risk. SLURP1 was confirmed in the replication phase, with a meta-analysis showing an odds ratio of 1.50 (95% CI: 1.30-1.74, P < 0.001). Phe-WAS indicated potential side effects for these targets.</p><p><strong>Conclusion: </strong>This study provides insights into the causal relationships of plasma proteins with BCa, identifying PSCA, LY6D, and SLURP1 as potential therapeutic targets, with implications for future BCa treatment strategies.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"24 1","pages":"273"},"PeriodicalIF":1.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}