BMC Urology最新文献

{"title":"A decreased waist area is a risk factor of recurrent nephrolithiasis after ureteroscopy for Nonobese female patients: a retrospective study from a regional referral hospital in Japan.","authors":"Hiroaki Kakinoki, Yuka Kakinoki, Kazuma Udo, Shohei Tobu, Mitsuru Noguchi","doi":"10.1186/s12894-025-01920-6","DOIUrl":"10.1186/s12894-025-01920-6","url":null,"abstract":"<p><strong>Background: </strong>Obesity and metabolic syndrome have been identified as risk factors for nephrolithiasis. Although dietary improvements and exercise effectively prevent cardiovascular disease, their impact on recurrent nephrolithiasis has not been well studied. We investigated the associations between changes in body shape and recurrent nephrolithiasis.</p><p><strong>Methods: </strong>Patients who underwent computed tomography (CT) twice at intervals of more than 12 months after retrograde ureteroscopy to treat upper urinary stones of the calcium component from January 2014 to December 2021 at our hospital were retrospectively included. The changes in waist area (WA) according to CT, age, sex, previous stone episodes, number of stones at surgery, residual stones after surgery, and body mass index (BMI) at surgery were compared with those of patients who experienced recurrence and those who did not experience recurrence via univariate and multivariate analyses.</p><p><strong>Results: </strong>A total of 96 patients were included in this study, with 48 patients in the recurrence group and 48 patients in the nonrecurrence group. The median age was younger in the recurrence group than in the nonrecurrence group (61.5 versus 70.5 years). The median BMI was 23 in both the recurrence group and the nonrecurrence group. The rate of recurrence in female patients with a decreased WA was greater than that in those with an increased WA (n = 9/5 versus 4/16) (p = 0.0137). Age under 70 years and a decreased WA were significant risk factors for the recurrence of renal stones according to multivariate analysis (p < 0.05).</p><p><strong>Conclusion: </strong>A decreased WA on CT images is a risk factor for recurrent nephrolithiasis after ureteroscopy, especially in nonobese female patients.</p><p><strong>Trial registration: </strong>Trial registration was not performed, and the number of clinical trials was not suitable because this was a retrospective observational study at a single institution. All participants were retrospectively registered, and the study was approved by the Institutional Review Board and Ethics Committee of the Faculty of Medicine, Saga Japan (number 2023-11-R-4) at the date of 2/02/2024.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"234"},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of total tubeless mini-PCNL in the management of renal stones: prospective observational study.","authors":"Bikash Bikram Thapa, Suman Thapa, Narayan Thapa, Pratik Man Singh Gurung","doi":"10.1186/s12894-025-01934-0","DOIUrl":"10.1186/s12894-025-01934-0","url":null,"abstract":"<p><strong>Introduction: </strong>Percutaneous nephrolithotomy (PCNL) is the standard practice for the treatment of large renal stones. There has been a gradual shift from \"standard\" PCNL to increasingly less invasive forms of PCNL in recent years. Innovations in both the technology and techniques of PCNL continue to improve the safety and efficacy of renal stone surgery. Total tubeless mini-PCNL (TTmPCNL) is a minimally invasive form of PCNL where the risks and benefits are still under evaluation. The aim of this study was to assess the safety and efficacy of TTmPCNL.</p><p><strong>Methods: </strong>This observational study was conducted in the Urology unit, Department of Surgery, Nepalese Army Institute of Health Sciences (NAIHS), from January 2025 to May 2025. All patients fulfilling the inclusion criteria (stone size 10-30 mm, no urinary tract infection, age ≥ 18 years) underwent prone TTmPCNL utilising pneumatic lithotripsy under fluoroscope guidance were enrolled in the study. Follow-up was performed to determine the stone-free rate (SFR), incidence of postoperative complications, and length of hospital stay.</p><p><strong>Results: </strong>A total of 44 TTmPCNL procedures were performed in patients aged 45.1 ± 13 years (mean ± standard deviation (SD)). The size of the renal stone was 19.7 ± 4.9 mm (mean ± SD). Stone complexity burden was assessed using Guy's stone scoring system (GSS). The postoperative decrease in haemoglobin was 1.32 ± 0.47 gm/dl (mean ± SD), the postoperative complication rate was 15.9%, and the SFR was 95.5%. The length of hospital stay was 1.5 ± 0.6 (mean ± SD) days. Significant differences in the stone-free rate (p = 0.02) and incidence of postoperative complications (0.008) were noted among different GSS groups.</p><p><strong>Conclusion: </strong>TTmPCNL is a safe and effective surgical treatment option for the treatment of carefully selected renal stone disease, with an acceptable complication rate, short hospital stays, and high SFR.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"238"},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' experiences and needs of undergoing holmium laser enucleation of the prostate in the surgical process: a qualitative study.","authors":"Wen-Lin Cheng, Shuo Wang, Rui Li, Guangming Zhang","doi":"10.1186/s12894-025-01927-z","DOIUrl":"10.1186/s12894-025-01927-z","url":null,"abstract":"<p><p>This study aimed to investigate the real experience and specific needs of patients undergoing holmium laser enucleation of the prostate, to provide appropriate nursing strategies for reference in the perioperative management of patients undergoing this type of surgery. The descriptive phenomenological research method in qualitative research was selected for this study. Purposive sampling method was used to select 10 patients who underwent holmium laser enucleation of the prostate in a tertiary hospital in Shanghai from May to June 2023 for semi-structured interviews, and the results of the interviews were compiled and analyzed using the Colaizzi seven-step analysis method. The surgical process experience and needs of patients undergoing holmium laser enucleation of the prostate were summarized and organized into three major themes and eight minor themes: (i) overall perception of the preoperative surgical process (unexpected admission experience, uncertain preoperative waiting time, and inadequate preoperative informational support), (ii) complex intraoperative sensory experience (unfamiliar surgical staff, cold surgical environment, and noisy surgical sounds), and (iii) postoperative continuity of care needs (diverse forms of health education, personalized health education content). These findings recommend to strengthen preoperative education to enhance patients' cognitive preparedness, to improve intraoperative care by addressing complex environmental stimuli through humanistic nursing, and to provide diverse health education that supports continuity of care throughout the perioperative process. This will further improve the hospitalization experience of patients undergoing holmium laser enucleation of the prostate, meet practical needs, and provide a valuable reference for perioperative comfort management and nursing strategy development for this group of patients undergoing HoLEP.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"236"},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of non-clear cell histology on recurrence and cancer-free survival in renal cell carcinoma: a time-to-event analysis.","authors":"Waseem Tayeb, Abdulaziz Bakhsh, Mahmoud Faisal, Mohnna Subahi, Hashim Naji, Hattan Badr, Turky Almohaisen, Sameer Munshi, Mohamed A Elkoushy","doi":"10.1186/s12894-025-01906-4","DOIUrl":"10.1186/s12894-025-01906-4","url":null,"abstract":"<p><strong>Objectives: </strong>To determine risk factors associated with the recurrence of renal cell carcinoma (RCC), either local recurrence or distant metastasis, and to characterize a contemporary cohort of patients with non-clear RCC (ncRCC) in terms of cancer-free survival (CFS) and time to such recurrence.</p><p><strong>Methods: </strong>A retrospective review of prospectively collected data was performed for consecutive patients undergoing partial and radical nephrectomy at a tertiary care center in Saudi Arabia. Data collection included patients and tumor characteristics, perioperative parameters, and histopathological patterns. Multivariate logistic regression determined the predictors of tumor recurrence while Kaplan-Meier analyses assessed CFS and the time to recurrence.</p><p><strong>Results: </strong>A total of 214 patients were analyzed, including 150 (70.1%) ccRCC and 64 (29.9%) ncRCC, with a mean age of 54.8 ± 1.7 years and tumor size of 6.9 ± 0.7 (1.2-24.0) cm. After a median follow-up of 47.6 ± 12.4 months, 32(14.9%) patients developed recurrence. In multivariate regression, tumor recurrence was significantly associated with tumors ≥ 6.9 cm [aOR (95% CI): 2.85 (1.67-5.43)], renal vein or inferior vena cava vascular invasion [aOR: 1.92 (1.32-4.21)], pathological staging ≥ 2b [aOR: 2.66 (1.95-5.34)] (8th edition of the AJCC Cancer Staging Manual, 2017), and positive lymph nodes in the specimen [aOR: 3.28 (2.97-5.15)]. The recurrence-free status was 85% at 5 years, while the mean time to recurrence was 9 (6-42) months. Patients with ncRCC had comparable recurrence rates to those with ccRCC (12.5% vs. 16.0% p = 0.64), respectively. The 5-year CFS was 62.8% (95% CI: 54.2-68.7) for ncRCC and 76.8% (95% CI: 67.4-87.2) for ccRCC (p = 0.77).</p><p><strong>Conclusion: </strong>Compared to clear cell RCC, patients with non-clear cell RCC showed no significant differences in demographic, tumor, or perioperative characteristics. In our cohort, both histopathological subtypes demonstrated comparable recurrence rates and 5-year cancer-free survival.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"237"},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative real-world study of apalutamide and darolutamide in Japanese patients with non-metastatic castration-resistant prostate cancer.","authors":"Maiko Ikeda, Koichi Uemura, Yusuke Ito, Hiroki Ito, Takashi Kawahara, Hisashi Hasumi, Jun-Ichi Teranishi, Kazuhide Makiyama, Hiroji Uemura","doi":"10.1186/s12894-025-01919-z","DOIUrl":"10.1186/s12894-025-01919-z","url":null,"abstract":"<p><strong>Background: </strong>Non-metastatic castration-resistant prostate cancer (nmCRPC) is often asymptomatic but carries a risk of progression to metastatic disease. Apalutamide (APA) and darolutamide (DARO) have been shown to improve metastasis-free survival (MFS). This study evaluated the real-world efficacy and safety of APA and DARO in Japanese patients with nmCRPC.</p><p><strong>Methods: </strong>We retrospectively analyzed 67 nmCRPC patients treated with APA (n = 32) or DARO (n = 35). Outcomes included time to treatment discontinuation or mCRPC progression, time to mCRPC, PSA response rate, treatment-related adverse events (TRAEs), post-mCRPC treatment patterns, and predictors of progression.</p><p><strong>Results: </strong>In patients with prostate-specific antigen doubling time (PSADT) < 10 months, no significant difference was observed between the APA and DARO groups in the time to progression to mCRPC. PSA response and MFS were comparable between groups. TRAEs were significantly more frequent with APA (75.0% vs. 25.7%), with rash being the most common. High PSA at treatment initiation (≥ 3.6 ng/mL) and PSA response < 90% were independent predictors of progression. Abiraterone was the most common first-line agent after mCRPC.</p><p><strong>Conclusions: </strong>DARO was associated with a lower incidence of TRAEs compared to APA. Rash was more prevalent with APA. Elevated baseline PSA and suboptimal PSA response were associated with progression.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"235"},"PeriodicalIF":1.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tip-flexible suctioning ureteral access sheath combined with flexible ureteroscope: a single-institution experience including in vitro experiments.","authors":"Tao Wang, Jielong Zhou, Xinyu Zhai, Xiaocheng Sun, Yan Wang, Cheng Ma, Dexin Song, Dongliang Xu, Chuanmin Chu","doi":"10.1186/s12894-025-01922-4","DOIUrl":"10.1186/s12894-025-01922-4","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the clinical application value of tip-flexible suctioning ureteral access sheath (TFS-UAS), this study compares the efficacy and safety of TFS-UAS versus traditional ureteral access sheath (T-UAS) in treating unilateral renal or proximal ureteral calculi, and further summarizes the usage strategy of TFS-UAS by synthesizing vitro experiment and surgical best practices.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 196 patients with renal or proximal ureteral calculi treated with FURS and holmium laser lithotripsy at Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Patients were divided into TFS-UAS and T-UAS groups. Primary data included operative time, immediate SFR (iSFR), and 2-week SFR. Secondary data encompassed changes in blood parameters (leukocytes, hemoglobin, urea nitrogen, creatinine), complications, and hospital stay.</p><p><strong>Results: </strong>This retrospective study found that urologists preferred to use TFS-UAS for larger (17.73 ± 7.79 mm vs. 12.56 ± 5.14 mm, P < 0.001), harder (1156.52 ± 420.15 vs. 778.39 ± 513.46 Hounsfield units, P < 0.001), and more complex (modified STONE score: 10.86 ± 2.51 vs. 7.37 ± 2.28, P < 0.001) upper urinary tract calculi. No significant differences in operative time or SFR were found between the TFS-UAS and T-UAS groups overall. However, for stones ≥ 15 mm, those that were larger(22.57 ± 6.35 mm vs. 18.70 ± 3.82 mm, P = 0.001), harder(1160.76 ± 382.84 vs. 896.56 ± 465.33, P = 0.007), and more complex(modified STONE score: 11.43 ± 2.40 vs. 8.63 ± 2.31, P < 0.001), TFS-UAS significantly reduced operative time (53.92 ± 21.77 vs. 65.76 ± 22.43 min, P < 0.001) and improved iSFR(91.89% vs. 73.17%, P = 0.063), 2-week SFR(81.08% vs. 56.10%, P = 0.018).</p><p><strong>Conclusions: </strong>TFS-UAS combined with FURS significantly improves operative efficiency and SFRs for upper urinary tract calculi ≥ 15 mm, demonstrating clinical advantages.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"232"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super multiple-tract minimally invasive percutaneous nephrolithotomy in one stage for treating complex renal stones: an initial experience.","authors":"Huacai Zhu, Guofeng Yu, Zijie Mai, Zhilin Li, Donglong Cheng, Gaoyuanzhi Yue, Zhanping Xu, Yongda Liu","doi":"10.1186/s12894-025-01933-1","DOIUrl":"10.1186/s12894-025-01933-1","url":null,"abstract":"<p><strong>Background: </strong>Complex kidney stones usually require multi-tract percutaneous nephrolithotomy (PCNL) to remove the stone completely. The aim of this study was to evaluate the clinical feasibility and safety of super multiple-tract (≥ 5 tracts) minimally invasive percutaneous nephrolithotomy (Mini-PCNL) in one stage for treating complex renal stones.</p><p><strong>Methods: </strong>From March 2019 to August 2023, the perioperative clinical data of 35 patients who underwent super multiple-tract Mini-PCNL for complex kidney stones in our institution were collected and analyzed, retrospectively.</p><p><strong>Results: </strong>A total of 35 patients were included in this study. The mean stone size and volume were 78.9 ± 22.8 mm and 13792.4 ± 5509.3 mm³, respectively. The mean S.T.O.N.E. score was 10.8, including 21 patients (60.0%) with scores ≥ 11. The average Guy's stone score was 3.5. The mean number of percutaneous tracts was 6.3 (range, 5-13). The average surgery time and length of hospital stay were 149.8 min and 3.4 days, respectively. The mean serum creatinine level declined by 6.5 mol/L (P = 0.518) and the mean hemoglobin drop was 24.9 g/L (P < 0.001). The postoperative complication rate was 25.7%, including one case of severe complication (Clavien grade IV). The mean follow-up time was 3.5 months, and the average glomerular filtration rate declined by 1.1 ± 8.7 ml/min (P = 0.463). The stone free rate was 82.9% after one- stage super multiple-tract Mini-PCNL.</p><p><strong>Conclusion: </strong>When performed by experienced urologists, super multiple-tract Mini-PCNL for treating some complex renal stones in one stage is feasible and safe in enhancing the stone-free rate.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"233"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of prolonged post-operative pelvic pain after transurethral prostate surgery: a clinical real-world survey and international comparison of therapy regimens.","authors":"Max Traeger, Tabea Walther, Jeremy Yuen-Chun Teoh, Marcelo Langer Wroclawski, Thomas Herrmann, Arkadiusz Miernik, Konrad Wilhelm, Maximilian Glienke, Philippe-Fabian Pohlmann, Christian Gratzke, Dominik Schoeb","doi":"10.1186/s12894-025-01943-z","DOIUrl":"10.1186/s12894-025-01943-z","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"231"},"PeriodicalIF":1.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning model in multi-omics perspective demystifies the prognostic significance of crotonylation heterogeneity in clear cell renal cell carcinoma.","authors":"Haojie Dai, Kai Zhao, You Zhao, Ke Jiang, Zhenyu Hang, Xin Huang, Weiping Luo, Jun Nie, Chao Qin, Weiwen Zhou","doi":"10.1186/s12894-025-01914-4","DOIUrl":"10.1186/s12894-025-01914-4","url":null,"abstract":"<p><strong>Background: </strong>Crotonylation, a post-translational modification, is implicated in cancer progression, but its prognostic significance in clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to demystify crotonylation heterogeneity and establish a robust prognostic model for ccRCC.</p><p><strong>Methods: </strong>Using multi-omics approaches, we analyzed transcriptomic data from TCGA-KIRC and GEO cohorts (GSE40435, GSE167573, GSE29609). Crotonylation scores were calculated via ssGSEA, with related gene modules identified through WGCNA. We integrated 10 machine learning algorithms to develop a prognostic model. Immune microenvironment was profiled using Cibersort, mutation landscapes via maftools, and drug sensitivity through oncoPredict. Spatial transcriptomics and single-cell data were analyzed for expression patterns, validated by qRT-PCR in 786-O and HK-2 cell lines.</p><p><strong>Results: </strong>Dysregulation of 16/18 crotonylation-related genes was observed in ccRCC. WGCNA revealed crotonylation related modules significantly enriched in angiogenesis, calcium/Ras signaling, and cancer stemness pathways. A 5-gene prognostic model (PLCL1, DNASE1L3, CD248, CDH13, PDGFD) demonstrated robust stratification: High-risk patients showed poorer overall survival, higher Treg infiltration, elevated tumor mutation burden and increased sensitivity to several chemotherapy approaches like Cisplatin. Molecular docking identified diacetylmorphine as a potential therapeutic agent (binding energy: -7.278 kcal/mol with DNASE1L3). Spatial/single-cell analyses confirmed cell-type-specific gene expression and the diffferential expression between tumor and normal cell lines was validated by qRT-PCR.</p><p><strong>Conclusion: </strong>This study establishes a crotonylation-based prognostic model that effectively stratifies ccRCC risk and elucidates key mechanisms linking crotonylation heterogeneity to immune evasion, mutational burden, and metabolic reprogramming. The model offers clinical utility for personalized therapy selection.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"229"},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial.","authors":"Ahmed Shoukry, Yasser ElKassar, Michaella K Hezagirwa, Rehab El-Said","doi":"10.1186/s12894-025-01929-x","DOIUrl":"10.1186/s12894-025-01929-x","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"230"},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}