BMC UrologyPub Date : 2025-07-04DOI: 10.1186/s12894-025-01834-3
Anh T Nguyen, Jill C Buckley
{"title":"A novel robotic ureteral reconstruction technique for complex proximal strictures renal pelvis flap augmentation and buccal mucosal graft.","authors":"Anh T Nguyen, Jill C Buckley","doi":"10.1186/s12894-025-01834-3","DOIUrl":"10.1186/s12894-025-01834-3","url":null,"abstract":"<p><strong>Introduction: </strong>Complex proximal ureteral strictures can pose significant surgical challenges, including long or obliterated strictures, inability to perform primary anastomotic repairs, fixed renal pelvis, impaired vascular supply from prior surgeries, and poor healing of the proximal ureter. We describe a novel surgical technique for addressing these issues.</p><p><strong>Methods: </strong>Our technique involves a combination of ureterolysis, renal pelvis flap creation, and buccal mucosal grafting. The procedure commences with exposure of the renal pelvis, creation of a U-shaped renal pelvis flap as the posterior plate and a buccal mucosa graft as the anterior plate. The omentum is then secured to provide a vascular bed for the graft.</p><p><strong>Results: </strong>A total of 4 patients were included, with a mean age of 49 years. The median operating time was 4.08 h. The median post-operative length of stay was 1.5 days. At initial mean radiographic follow-up period of 3.2 months the success rate of the reconstruction was 100% with all patients demonstrating complete resolution of symptoms and radiographic improvement. Long-term follow-up was on average 22.3 months with sustained stability/improvement in radiographic hydronephrosis and symptoms, with no evidence of stricture recurrence. There were no donor site complications.</p><p><strong>Conclusion: </strong>This novel surgical technique, involving ureteroplasty with a renal pelvis flap augmentation and buccal mucosal graft (RPFA-BMG), proves effective for complex proximal ureteral reconstruction. It is particularly suitable for long proximal obliterated strictures that require a combination of tissue transfer techniques for successful ureteral reconstruction and achievement of physiologic drainage.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"156"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC UrologyPub Date : 2025-07-04DOI: 10.1186/s12894-025-01837-0
Katrine Ørum, Dag R Stormoen, Jakob Lauritsen, Mikkel Rohde, Marja Jäättelä, Helle Pappot
{"title":"An example of drug repurposing: ebastine in combination with docetaxel as a treatment for metastatic castration-resistant prostate cancer-the EXUROC prostate study, a clinical trial protocol.","authors":"Katrine Ørum, Dag R Stormoen, Jakob Lauritsen, Mikkel Rohde, Marja Jäättelä, Helle Pappot","doi":"10.1186/s12894-025-01837-0","DOIUrl":"10.1186/s12894-025-01837-0","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"154"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors influencing Gleason score up/downgrade in radical prostatectomy.","authors":"Zafer Gokhan Gurbuz, Umut Unal, Ediz Vuruskan, Mubariz Aydamirov, Kadir Karkin","doi":"10.1186/s12894-025-01848-x","DOIUrl":"10.1186/s12894-025-01848-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the preoperative and pathological gleason score (GS) concordance rates and biopsy, pathological and clinical parameters that may cause discordance in patients who underwent radical prostatectomy (RP) for prostate cancer (PCa) in a single tertiary referral center.</p><p><strong>Patients and methods: </strong>The data for patients who underwent RP due to PCa were retrospectively scanned after obtaining approval from the local ethics committee. Preoperative age, total PSA value, prostate volume, PSA density, PI-RADS score, digital rectal examination findings, biopsy type and pathological parameters after RP were evaluated in terms of GS concordance. Upgrading or downgrading was defined as an increase or decrease from one GS group to another.</p><p><strong>Results: </strong>While preoperative and pathological GS were concordant in 151 patients (56.1%), values in 118 patients (43.9%) were found to be discordant. Of the 118 patients with preoperative and pathological discordance, 41 patients (34.7%) were downgraded, and 77 patients (65.3%) were upgraded. When preoperative and pathological GS concordance is compared, International Society of Urological Pathology grade group, D'Amico risk classification and clinical stage affected downgrading or upgrading of patients. In the presence of perineural, lymphovascular, seminal vesicle invasion and positive surgical margins in pathological examinations, GS discordance increased (p = 0.020, p = 0.003, p = 0.006 and p = 0.003, respectively).</p><p><strong>Conclusions: </strong>According to the results of our study, one out of every two patients who underwent RP due to PCa had preoperative and pathological GS discordance.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"155"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC UrologyPub Date : 2025-07-04DOI: 10.1186/s12894-025-01835-2
Mehran Saberian, Alireza Amirabadizadeh, Mohammad Saatchi, Ahmad Delbari
{"title":"Lower urinary tract symptoms (LUTS) and sleep quality: the mediating role of anxiety and depression in middle-aged and older adults from the ardakan cohort study on aging (ACSA).","authors":"Mehran Saberian, Alireza Amirabadizadeh, Mohammad Saatchi, Ahmad Delbari","doi":"10.1186/s12894-025-01835-2","DOIUrl":"10.1186/s12894-025-01835-2","url":null,"abstract":"<p><strong>Background: </strong>The present study investigated the prevalence of LUTS and its relationship with sleep quality in Iranian older adult.</p><p><strong>Methods: </strong>The data used in this cross-sectional study were extracted from the first phase of the Ardakan Cohort Study on Aging (ACSA). The study included 2716 men aged ≥ 50 years living in Ardakan City. The Pittsburg Sleep Quality Index (PSQI) and International Prostatism Symptom Score (IPSS) questionnaires were used to measure sleep quality and LUTS, respectively. Confirmatory Factor Analysis (CFA) was used to examine the relationship between LUTS and sleep quality, considering the mediating role of anxiety and depression.</p><p><strong>Results: </strong>The average age of the men was 63.3 ± 8.2 years. The prevalence of moderate LUTS was 20.9% (CI: 19.4 - 22.4%), and severe LUTS was 4.4% (CI: 3.7 - 5.3%). A statistically significant positive correlation was observed between sleep quality with LUTS (r = 0.21, P-value < 0.001), depression (r = 0.45, P-value < 0.001), and anxiety (r = 0.40, P-value < 0.001). LUTS leads to poor sleep quality directly (β = 0.08, P-value = 0.03) and indirectly, considering the mediating role of depression and anxiety factors (β = 0.25, P-value = 0.007).</p><p><strong>Conclusion: </strong>The prevalence of LUTS among middle-aged and older adults in Ardakan city was lower compared to similar populations elsewhere. Additionally, LUTS affects sleep quality in individuals over 50 both directly and indirectly through anxiety and depression.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"157"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC UrologyPub Date : 2025-07-04DOI: 10.1186/s12894-025-01849-w
Junwei Li, Jiwang Deng, Zijian Tang, Chen Wang, Junjin Zhang, Bin Lai, Yongmao Zeng, Lian Peng, Qingjiang Chen, Shuangquan Gao, Liqun Zhong, Yuefu Han
{"title":"Case report and literature review of complex renal angiomyolipoma.","authors":"Junwei Li, Jiwang Deng, Zijian Tang, Chen Wang, Junjin Zhang, Bin Lai, Yongmao Zeng, Lian Peng, Qingjiang Chen, Shuangquan Gao, Liqun Zhong, Yuefu Han","doi":"10.1186/s12894-025-01849-w","DOIUrl":"10.1186/s12894-025-01849-w","url":null,"abstract":"<p><p>Renal angiomyolipoma (AML) is a rare benign renal tumor with notable clinical implications, including potential compression of adjacent organs and a heightened risk of spontaneous hemorrhage, particularly when the tumor grows large. We present a complex case involving renal AML in a 52-year-old male patient who exhibited persistent left flank pain. Radiological imaging revealed a bilateral AML, with the most significant lesion on the left measuring approximately 13.5 × 19.3 × 15.6 cm. This lesion was associated with multiple renal stones, fluid accumulation, and atrophy of the left kidney. Surgical intervention was necessary, leading to open nephrectomy and removal of the left renal mass. Histopathological examination confirmed the diagnosis of renal angiomyolipoma and left renal atrophy. This case report provides critical insights into the multifaceted nature of renal AML, covering its pathogenesis, clinical presentation, diagnosis, and treatment, and thus enhances the understanding and management of this condition in clinical practice.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"158"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enterovesical fistula in chronic lymphocytic leukemia transforming to Richter syndrome: a case report and literature review.","authors":"Mobina Saleh, Babak Alavi Farzaneh, Fatemeh Zarimeidani, Rahem Rahmati, Yaser Salehi Najafabadi, Fatemeh Taheri","doi":"10.1186/s12894-025-01830-7","DOIUrl":"10.1186/s12894-025-01830-7","url":null,"abstract":"<p><p>Richter transformation (RT) is an uncommon complication of chronic lymphocytic leukemia (CLL) that can lead to aggressive large B-cell lymphoma or Hodgkin lymphoma. Here, we present a rare case of enterovesical fistula (EVF) resulting from RT of CLL. A 59-year-old Caucasian male with CLL visited the hematology department with severe abdominal pain in the hypogastrium. Ultrasonography showed an increase in wall thickness in a segment of the ileum with adjacent lymphadenopathy, indicating lymphomatous involvement. A day after receiving chemotherapy, the patient complained of hematuria. He underwent a cystoscopy, which revealed no abnormal findings. After the cystoscopy, the patient's hematuria stopped, but he complained about the excretion of food from the previous day in his urine. The patient's CT cystography results were normal. However, the abdominopelvic CT scan revealed an increase in the thickness of the small intestine loops in the distal part of the jejunum without any evidence of obstruction, suggesting lymphomatous involvement. Based on the patient's fecaluria, he uneventfully underwent surgery, and EVF was confirmed. Resection of the involved small intestine and partial cystectomy were done. The pathology results suggested RT of CLL to diffuse large B-cell lymphoma (DLBCL). Not only EVF might be an uncommon complication of CLL, but it could also manifest in patients undergoing RT due to the disease's characteristics or as a result of treatment. It is essential for clinicians managing CLL patients to be aware of the RT and its complications.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"150"},"PeriodicalIF":1.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Off-clamp robot-assisted nephron-sparing surgery is associated with less operative time and potential for vascular complication in the treatment of renal angiomyolipoma > 4 cm: a comparative study.","authors":"Yue Xue, Guoling Zhang, Haoxun Zhang, Jiuliang Wang, Zhixing Jiao, Guang Jia, Ao Qi, Yipeng Yu, Yiwen Liu, Bowen Wang, Feng Xiong, Chunyang Wang","doi":"10.1186/s12894-025-01836-1","DOIUrl":"10.1186/s12894-025-01836-1","url":null,"abstract":"<p><strong>Background: </strong>Off-clamp robot-assisted nephron-sparing surgery (NSS) has emerged as a viable option for most localized renal carcinomas. However, its application in > 4 cm renal angiomyolipoma (RAML) is still challenging, and its safety and efficacy merit further investigations. This paper aims to compare perioperative parameters of RAML > 4 cm between off-clamp and on-clamp robot-assisted NSS using single-center data.</p><p><strong>Methods: </strong>From September 2022 and February 2025, 55 patients who underwent robot-assisted NSS for RAML > 4 cm from the First Affiliated Hospital of Harbin Medical University were included in the retrospective study. Among these patients, 28 underwent off-clamp robot-assisted NSS (Offc-RAPN group), while 27 underwent on-clamp robot-assisted NSS (Onc-RAPN group). Baseline characteristics and perioperative outcomes were collected and assessed.</p><p><strong>Results: </strong>All patients successfully underwent robot-assisted NSS, and none of them experienced conversion to open surgery or nephrectomy. Additionally, none in Offc-RAPN group converted to renal hilar clamping. The two groups manifested no significant differences in baseline characteristics. Compared to Onc-RAPN group, Offc-RAPN group exhibited shorter operative time, while showing comparable serum creatinine (Scr) change, estimated glomerular filtration rate (eGFR) change, hemoglobin (Hb) change, postoperative length of stay (PLOS), estimated blood loss (EBL) and rate of minor complications.</p><p><strong>Conclusions: </strong>Off-clamp robot-assisted NSS offers shorter operative time and less potential for vascular complication than on-clamp robot-assisted NSS without increasing PLOS, EBL, and other complications. Hence, off-clamp robot-assisted NSS may be a safe and feasible approach for > 4 cm RAML.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"149"},"PeriodicalIF":1.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incarcerated prolapsed ureterocele complicated by postoperative acute pyelonephritis: a case report.","authors":"Changchang Hu, LuYang Han, Tian Ding, Zhu Cao, Hangmei Jin, Yinfeng Wang","doi":"10.1186/s12894-025-01842-3","DOIUrl":"10.1186/s12894-025-01842-3","url":null,"abstract":"<p><strong>Background: </strong>A ureterocele is a cystic dilatation of the terminal ureter that can be located entirely within the bladder or extend into the urethra. In rare cases, female patients may present with a vaginal mass due to prolapse of an ectopic ureterocele and experience urinary incontinence due to laxity of the external urinary sphincter.</p><p><strong>Case presentation: </strong>A 37-year-old female presented with a one-year history of recurrent urinary symptoms, including frequent urination, urgency, and dysuria. Over the past two months, she noticed a prolapsed vulvar mass accompanied by urinary incontinence. Three weeks prior to admission, she underwent tension-free vaginal tape-obturator (TVT-O) surgery at another hospital for presumed stress urinary incontinence (SUI). Three days ago, the vulvar mass increased to the size of an egg and could not be manually reduced, accompanied by straining during voiding. Ultrasound and MRI revealed bilateral ureteroceles, with the left ureterocele prolapsed from the bladder to the urethral opening. A diagnosis of ureterocele prolapse with incarceration was made, and the patient underwent manual reduction followed by cystoscopic resection of the left ureterocele. Two days postoperatively, she developed acute pyelonephritis, which was successfully treated with antibiotics.</p><p><strong>Discussion and conclusions: </strong>Prolapsed ureteroceles are a rare condition, and their symptoms can mimic those of SUI, which is typically treated with midurethral sling procedures. However, this treatment approach may inadvertently result in an incarcerated prolapsed ureterocele, requiring urgent medical intervention. This case emphasizes the critical importance of accurate diagnosis of ureteroceles to avoid inappropriate application of midurethral slings and highlights the need for vigilance regarding the potential development of acute pyelonephritis following ureterocele resection.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"152"},"PeriodicalIF":1.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC UrologyPub Date : 2025-07-03DOI: 10.1186/s12894-025-01833-4
Chang Liu, Yang Sun, Yongyue Zhang, Rongjin Zhang, Liwei Li, Shumin Wang, Huiying He
{"title":"Clinical and imaging characteristics of classic angiomyolipoma with venous tumor thrombosis: a comparative analysis against renal cell carcinoma.","authors":"Chang Liu, Yang Sun, Yongyue Zhang, Rongjin Zhang, Liwei Li, Shumin Wang, Huiying He","doi":"10.1186/s12894-025-01833-4","DOIUrl":"10.1186/s12894-025-01833-4","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively analyze the clinical and imaging characteristics of classic angiomyolipoma (CAML) with venous tumor thrombus (VTT) and compare them with those of clear cell renal cell carcinoma (ccRCC).</p><p><strong>Methods: </strong>Clinical data from six patients with renal CAML complicated by VTT and 18 with ccRCC complicated by VTT, treated at Peking University Third Hospital from April 2018 and June 2022, were retrospectively analyzed. All patients underwent preoperative ultrasound and contrast-enhanced CT. Clinical manifestations, imaging characteristics, surgical findings, and pathological data were collected, and patients were followed up.</p><p><strong>Results: </strong>Enhanced CT showed renal sinus involvement in all CAML cases versus four ccRCC cases (p = 0.002). All primary CAML tumors had fatty components, compared to one ccRCC case (p < 0.001). Enhanced CT also revealed 7 VTTs with fatty components (6 in the CAML group) (p < 0.001). Thrombus lengths in the inferior vena cava (IVC) were 8.05 ± 2.22 cm for CAML and 5.29 ± 2.38 cm for ccRCC, with no significant difference (p = 0.610). The maximum/minimum anteroposterior VTT diameter ratios were 3.98 and 1.09, respectively (p < 0.001); coronal diameter ratios were 4.00 and 1.12, respectively (p < 0.001). Ultrasound revealed that, except for one Mayo Level 0 case, the involved IVC in the CAML group had continuous, intact walls with blood flow signals in the residual lumen, while in the ccRCC group, most VTTs had unclear boundaries and only one case showed blood flow signals in the residual lumen (p = 0.001). Intraoperative blood loss was significantly lower in CAML cases (p = 0.017). No CAML patient had VTT invading the venous wall, unlike 8 ccRCC patients (p = 0.016). All patients were followed for 21-74 months (median: 34.5 months, mean: 36.6 months). All were alive with normal renal function, and no tumor recurrence or metastasis was observed.</p><p><strong>Conclusion: </strong>Renal CAML with VTT is characterized by three imaging features: the presence of fatty components, a unique geometric growth pattern, and the absence of venous wall invasion, potentially serving as valuable indicators for differentiating CAML from ccRCC lesions.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"151"},"PeriodicalIF":1.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC UrologyPub Date : 2025-07-03DOI: 10.1186/s12894-025-01844-1
Bing Li, Zhiqiang Zhang, Junping Li, Xiaoqiang Liu
{"title":"The relationship between the triglyceride glucose-waist height ratio and benign prostatic hyperplasia in middle-aged and elderly adults: a nationwide cohort study.","authors":"Bing Li, Zhiqiang Zhang, Junping Li, Xiaoqiang Liu","doi":"10.1186/s12894-025-01844-1","DOIUrl":"10.1186/s12894-025-01844-1","url":null,"abstract":"<p><strong>Objective: </strong>Currently, evidence regarding the relationship between variations in the Triglyceride Glucose-Waist-to-Height Ratio (TyG-WHtR) and benign prostatic hyperplasia (BPH) remains scarce. This study aimed to examine the potential association between alterations in TyG-WHtR and the risk of developing BPH.</p><p><strong>Methods: </strong>This study enrolled 3,296 male participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS). Multivariable logistic regression analysis combined with restricted cubic spline models was employed to explore the potential relationship between TyG-WHtR variation and the risk of developing BPH.</p><p><strong>Results: </strong>Over a 4-year follow-up period, 267 individuals were diagnosed with BPH. Elevated TyG-WHtR values were significantly associated with a higher risk of BPH (OR = 1.20, 95% CI: 1.02-1.43, p = 0.031), demonstrating a clear dose-response trend (p = 0.01). Furthermore, subgroup analyses revealed that this positive correlation between TyG-WHtR and BPH risk was consistently observed across multiple stratifications.</p><p><strong>Conclusion: </strong>These findings highlight the potential metabolic links between TyG-WHtR and BPH, and underscore the need for future longitudinal studies to explore whether targeting these pathways may aid in BPH prevention.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"153"},"PeriodicalIF":1.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}