BMC Urology最新文献

{"title":"The comparison of post-treatment quality of life after at least two years of follow-up (≥ 24 months) between robotic radical prostatectomy and radiotherapy for intermediate-risk localized prostate cancer.","authors":"Selahattin Bedir, Burak Ünal, Turgay Ebiloglu, Selçuk Demiral, Selçuk Sarıkaya, Mehmet Murat Beyzadeoğlu","doi":"10.1186/s12894-025-02018-9","DOIUrl":"10.1186/s12894-025-02018-9","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted laparoscopic radical prostatectomy (RALRP) and intensity-modulated radiotherapy (IMRT) are the main curative options for localized prostate cancer (PCA). However, both may significantly affect patients' quality of life (QoL).</p><p><strong>Objective: </strong>To retrospectively compare post-treatment QoL after at least 24 months of follow-up between bladder-neck- and nerve-sparing RALRP and IMRT in patients with intermediate-risk localized PCA.</p><p><strong>Methods: </strong>A total of 164 patients treated between October 2016 and May 2023 were analyzed (104 RALRP; 60 IMRT). QoL was evaluated using the Expanded Prostate Cancer Index Composite (EPIC-2002). Urinary, bowel, sexual, and hormonal domains were compared using appropriate statistical tests .</p><p><strong>Results: </strong>Baseline demographics were similar between groups. The mean age was 68.82 ± 6.72 years in the RALRP group and 68.89 ± 7.81 years in the IMRT group. IMRT patients reported better sexual function (p < 0.05), but this advantage was counteracted by hormonal side effects due to androgen deprivation therapy (ADT). Urinary continence was comparable (p > 0.05), whereas irritative urinary symptoms were more common in IMRT (p < 0.001). Bowel function and overall satisfaction were significantly better in RALRP (both p < 0.001).</p><p><strong>Conclusions: </strong>After ≥ 24 months of follow-up, RALRP provided superior bowel and hormonal outcomes, while IMRT yielded slightly better sexual function scores. Overall satisfaction favored RALRP.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of positive surgical margin location on biochemical recurrence in pT3 prostate cancer after robot-assisted radical prostatectomy: a retrospective cohort study.","authors":"Mehmet Sefa Altay, Hüseyin Kocatürk, Banu Bedir, Fevzi Bedir, Ahmet Emre Cinislioğlu, Ahmet Furkan Yeğen, Özkan Aydin, Abdullah Erdem Canda, Mevlana Derya Balbay","doi":"10.1186/s12894-026-02069-6","DOIUrl":"10.1186/s12894-026-02069-6","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of acute cold ischemia duration on testicular tissue.","authors":"Mustafa Kestel, H Deliktaş, I Akarken, B Şahin, Y Dere, E Saruhan, H Tarhan, H Şahin","doi":"10.1186/s12894-026-02071-y","DOIUrl":"10.1186/s12894-026-02071-y","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ileal ureter replacement for patients with long ureteral strictures after Allium stent failure: the initial experience.","authors":"Yiming Zhang, Xiang Wang, Zhihua Li, Guanpeng Han, Zihao Tao, Xinfei Li, Kunlin Yang, Bing Wang, Peng Zhang, Hongjian Zhu, Liqun Zhou, Kai Zhang, Xuesong Li","doi":"10.1186/s12894-026-02060-1","DOIUrl":"10.1186/s12894-026-02060-1","url":null,"abstract":"<p><strong>Purpose: </strong>To present the initial experience and clinical outcomes of ileal ureteric replacement (IUR) for complex ureteral stricture after treatment failure of Allium stents.</p><p><strong>Methods: </strong>From June 2020 to July 2022, a total of eight patients underwent IUR for complex ureteral strictures after treatment failure of Allium stents across three tertiary centers. Surgical approaches included open (n = 3), laparoscopic (n = 2), and robot-assisted (n = 3). The clinical data and follow-up results were prospectively collected.</p><p><strong>Results: </strong>A total of eight patients were enrolled, including seven women and one man, with a mean age of 47.8 years. The median dwelling time of Allium stents was 12.5 months. Reasons for Allium stent failure included recurrent urinary tract infection (UTI), stent migration, unrelieved hydronephrosis and stent calculus. The median stricture length was 15 cm. Four patients underwent unilateral IUR and four underwent bilateral IUR, with a median harvested ileal segment length of 25 cm. The median operation time was 261 min and the median estimated blood loss was 75mL. During a median follow-up of 24 months, ureteral patency was achieved in all patients. The mean eGFR was 71.2 ± 34.5 preoperatively and 65.9 ± 23.9 mL/min/1.73m² at the last follow-up (p = 0.394). Two patients in the open surgery group experienced major complications, specifically ileus and incisional hernia. Long-term minor complications included UTI (n = 5) and metabolic acidosis (n = 2).</p><p><strong>Conclusion: </strong>Allium stents should be applied with caution and strict indications. For patients experiencing stent failure, IUR serves as a viable salvage option for managing long and complex ureteral strictures.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOP2A drives T-cell infiltration and immune remodeling in cyclophosphamide-induced cystitis: a single-cell sequencing study with potential implications for interstitial cystitis.","authors":"Minli Shi, Wantong Xue, Xiaodong Wen, Lei Pang","doi":"10.1186/s12894-026-02061-0","DOIUrl":"10.1186/s12894-026-02061-0","url":null,"abstract":"<p><strong>Objective: </strong>To explore the potential mechanisms of interstitial cystitis (IC), we employed a cyclophosphamide (CYP)-induced cystitis rat model, a well-established tool for studying IC-like bladder inflammation and dysfunction. This study aimed to investigate the role of rhythmic genes and immune microenvironment remodeling in this model, focusing on TOP2A and its impact on T-cell infiltration.</p><p><strong>Methods: </strong>CYP-induced cystitis rat models were established using cyclophosphamide. Single-cell RNA sequencing was performed on bladder tissues to analyze cellular heterogeneity. Differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) identified rhythmic and immune-related gene clusters. TOP2A was validated via RT-PCR, Western blot, and immunohistochemistry (IHC). Statistical analyses assessed correlations between TOP2A, CD4 + T cells, and CD8 + T cells.</p><p><strong>Results: </strong>Single-cell sequencing revealed elevated T-cell infiltration in a CYP-induced cystitis rat model. TOP2A was the sole overlapping gene between rhythmic and immune clusters and showed significant upregulation in IC tissues (P < 0.05). IHC confirmed increased TOP2A, CD4 + T, and CD8 + T cell levels, with strong positive correlations (r = 0.89 and 0.64, respectively). Functional enrichment linked TOP2A to oxidative phosphorylation and ribosomal pathways.</p><p><strong>Conclusions: </strong>Our findings demonstrate that TOP2A drives immune dysregulation in CYP-induced cystitis by modulating T-cell infiltration. As T-cell infiltration is a hallmark of human IC, our findings in this CYP-induced model suggest that TOP2A may represent a novel therapeutic target worthy of further investigation in human IC tissues.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut-prostate axis in benign prostatic hyperplasia: systematic review of microbial dysbiosis and pathogenic mechanisms.","authors":"Yuanzhao Xu, Lingyue An, Jiling Xie, Chenggong Luo, Xiaoxue Huang, Guangheng Luo","doi":"10.1186/s12894-025-02003-2","DOIUrl":"10.1186/s12894-025-02003-2","url":null,"abstract":"<p><strong>Background: </strong>New evidence shows that gut microbiota dysbiosis may play a crucial role in the development process of benign prostatic hyperplasia (BPH). However, at present, the specific characteristics of the gut microbiota in patients with BPH have not been fully clarified.</p><p><strong>Methods: </strong>The PubMed, MEDLINE and Web of Science databases were systematically searched to find the clinical and preclinical studies related to the relationship between BPH and gut microbiota from the establishment of the databases to October 7, 2025. And the studies reporting on gut microbiota and BPH were analyzed.</p><p><strong>Results: </strong>A total of 10 preclinical studies and 6 clinical studies were included. These studies covered 413 patients with BPH, 338 controls, and 5 different types of BPH mouse models in total. Compared with the control group, there were significant differences in β-diversity in the BPH group. A significant increase in the Firmicutes/Bacteroidetes (F/B) ratio was regarded as a marker of the pathological condition. Specifically, changes in the abundances of Prevotella, Ruminococcus, and Lactobacillus may play a key role in the pathogenesis of the occurrence and development of BPH. The imbalance of interleukin-6 (IL-6) and interleukin-18 (IL-18), as well as changes in the levels of intestinal tight junction protein-1 and claudin-1, may also be related to the pathogenesis of BPH.</p><p><strong>Conclusions: </strong>Changes in the abundances of specific gut microbiota and their metabolites, such as an increased F/B ratio and a decreased abundance of Lactobacillus, as well as the levels of inflammatory indicators and markers of intestinal barrier dysfunction, may play a crucial role in the pathogenesis of BPH. These factors may become effective diagnostic means and potential therapeutic targets for BPH.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"26 1","pages":"26"},"PeriodicalIF":1.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel assistive device for enhancing extracorporeal shockwave lithotripsy in obese patients with distal ureteral stones.","authors":"Minghao Zhang, Peng Liu, Qi Wang, Fan Chang, Taipeng Li, Yuanjie Niu, Hailong Hu","doi":"10.1186/s12894-026-02065-w","DOIUrl":"10.1186/s12894-026-02065-w","url":null,"abstract":"<p><strong>Background: </strong>Obesity significantly increases the risk of developing urinary tract stones, particularly distal ureteral stones, which can complicate treatment with extracorporeal shockwave lithotripsy (SWL). In obese patients, the distance between the skin and the stone often exceeds the effective shockwave range, reducing SWL efficacy. This study presents an innovative SWL assistive device designed to address this challenge by using natural body passages such as the rectum or vagina to shorten the distance between the skin and the stone.</p><p><strong>Methods: </strong>Three obese patients with distal ureteral stones who were initially unsuitable for conventional SWL due to excessive skin-to-stone distance were included. An assistive device was used via natural body passages to reduce the skin-to-stone distance during SWL. Clinical outcomes were assessed by postoperative imaging. Descriptive analysis was performed.</p><p><strong>Result: </strong>In three obese patients with distal ureteral stones, the use of the device allowed SWL to be performed effectively, with no residual stones detected on follow-up imaging. The device has been patented in China (Patent No.: ZL 2020 2 2018950.0) and is undergoing larger-scale clinical trials to further evaluate its safety and efficacy.</p><p><strong>Conclusions: </strong>This development offers a promising solution for obese patients who were previously unable to undergo effective SWL treatment.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes between metallic and polymeric ureteral stents in malignant ureteral obstruction: a retrospective comparative study.","authors":"Tomohiro Nishi, Ryuto Nakazawa, Yuki Morimoto, Ryuji Yamada, Hikaru Tsukada, Daisuke Shirai, Naoto Yoza, Koichiro Aida, Eiji Kikuchi","doi":"10.1186/s12894-026-02062-z","DOIUrl":"10.1186/s12894-026-02062-z","url":null,"abstract":"<p><strong>Background: </strong>The present study compared the clinical outcomes and indications of metallic ureteral stents (MS) and polymeric ureteral stents (PS) in patients with malignant ureteral obstruction (MUO).</p><p><strong>Methods: </strong>We analyzed 148 patients (240 ureters) with MUO who underwent ureteral stent placement at our Department of Urology between December 2014 and April 2022. The cohort included 67 patients (112 ureters) who received metallic stents (MS group) and 81 patients (128 ureters) who received polymeric stents (PS group). We evaluated overall survival and the primary underlying malignancies, and compared operative times, ureteral stent patency rates, and factors associated with stent obstruction between the two groups.</p><p><strong>Results: </strong>The one-year overall survival rate of patients with MUO was 27.2%, with a median survival time of 209 days. The main primary malignancies were gynecologic and gastrointestinal cancers, most commonly cervical, gastric, colorectal, breast, and ovarian cancers, in that order. The operative time for stent insertion was significantly longer in the MS group than in the PS group for both bilateral (p = 0.0004) and unilateral (p = 0.0094) placements. The one-year stent patency rate was significantly higher in the MS group (62.0%) than in the PS group (48.5%) (p = 0.0144). Factors associated with stent obstruction included lower ureteral obstruction (p = 0.0401), direct tumor compression (p = 0.0172), pyuria (p = 0.0028), and elevated preoperative serum creatinine (p = 0.0088) in the MS group, and peritoneal dissemination (p = 0.0005) in the PS group. A comparison of stent patency between the groups according to obstruction factors showed no significant differences for lower ureteral obstruction (p = 0.5140), direct tumor compression (p = 0.8215), or pyuria (p = 0.8401). However, among patients with peritoneal dissemination, the stent patency period was significantly longer in the MS group (p = 0.0001).</p><p><strong>Conclusions: </strong>Metallic ureteral stenting, which has higher patency rates than PS, is a safe and effective treatment option for MUO, particularly in the patients with peritoneal dissemination.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12934001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZJU index and the prevalence of kidney stones in US adults: evidence from NHANES 2007-2018.","authors":"Suquan Zhong, Guoliang Li, Chao Tian, Tao Ding, Maolin Jiang, Pengfei Diao, Le Gan, Lin Ning","doi":"10.1186/s12894-026-02051-2","DOIUrl":"10.1186/s12894-026-02051-2","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones represent a prevalent urinary tract condition frequently observed in individuals with metabolic disturbances. The Zhejiang University (ZJU) Index, a composite metabolic indicator, has been proposed for metabolic evaluation; however, its connection with the occurrence of kidney stones has yet to be thoroughly investigated.</p><p><strong>Methods: </strong>This cross-sectional analysis utilized data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) to explore the association between the ZJU Index and kidney stone status. Multivariate logistic regression models were employed to estimate independent associations. Restricted cubic spline (RCS) and segmented regression methods were applied to characterize potential nonlinear trends. Robustness of findings was further examined through subgroup stratification and sensitivity procedures.</p><p><strong>Results: </strong>Among 14,593 participants, 1,401 reported a history of kidney stones. After adjustment for potential confounders, higher ZJU Index values were positively associated with kidney stone prevalence (odds ratio [OR] per 1-unit increase, 1.03; 95% confidence interval [CI], 1.03-1.04). Compared with the lowest quartile, the adjusted ORs for kidney stone prevalence were 1.45 (95% CI, 1.12-1.89), 1.75 (95% CI, 1.33-2.29), and 2.14 (95% CI, 1.62-2.82) across increasing ZJU Index quartiles (P for trend < 0.001). Restricted cubic spline analyses suggested a non-linear association, with a steeper increase at lower to moderate ZJU Index levels and attenuation of the association at higher levels. These associations were consistent across demographic subgroups and sensitivity analyses.</p><p><strong>Conclusion: </strong>In U.S. adults, elevated ZJU index levels are nonlinearly and positively associated with the prevalence of kidney stones, suggesting that the ZJU index may serve as a potential metabolic indicator for assessing urolithiasis risk. Given the routine availability and accessibility of its component variables, the ZJU index holds promise as a valuable tool for epidemiological screening and metabolic risk management in populations at high risk for kidney stones.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"26 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dutasteride with Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and survival in non-muscle invasive bladder cancer: a retrospective single-center study.","authors":"Ali Nebioğlu, Mert Başaranoğlu, Murat Bozlu, Mesut Tek, Erdem Akbay","doi":"10.1186/s12894-026-02059-8","DOIUrl":"10.1186/s12894-026-02059-8","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"26 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}