BMC Urology最新文献

{"title":"Sigmoidovesical fistula expansion with sepsis following transurethral resection of prostate: a case report.","authors":"Jinlin Xie, Yuguang Zhu, Weiming Liu, Jiarong Zeng, Siping Liu","doi":"10.1186/s12894-025-01894-5","DOIUrl":"10.1186/s12894-025-01894-5","url":null,"abstract":"<p><strong>Background: </strong>Sigmoidovesical fistula (SVF), a rare form of colovesical fistula, predominantly arises from colorectal neoplasms, diverticulitis, or radiation injury. However, no previous literature documents Sigmoidovesical fistula (SVF) expansion with sepsis following transurethral resection of prostate (TURP).</p><p><strong>Case presentation: </strong>We report a 73-year-old male with benign prostatic hyperplasia who developed SVF expansion and postoperative sepsis following TURP. Emergency transverse colostomy achieved infection control, followed by successful laparoscopic sigmoidectomy during secondary surgery.</p><p><strong>Conclusion: </strong>This case highlights the need to remain vigilant for occult SVF risks during TURP procedures. Transverse colostomy should be prioritized as damage control surgery for fistula-related sepsis.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"200"},"PeriodicalIF":1.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between urinary nitrate and prostate specific antigen without prostatic disease: a cohort study.","authors":"Zhiyi Chen, Enpu Zhang, Lu Gan, Wenjuan Zhang, Guixiao Huang","doi":"10.1186/s12894-025-01878-5","DOIUrl":"10.1186/s12894-025-01878-5","url":null,"abstract":"<p><strong>Purpose: </strong>The carcinogenic effects of nitrate reduction to nitrite are well established, and nitrate has been closely linked to various diseases. However, research on its effects on the urinary system remains limited, and its association with PSA remains unclear. This study aims to investigate the relationship between urinary nitrate and PSA.</p><p><strong>Methods: </strong>We employed weighted generalized linear models, weighted univariate analysis, forest plots, weighted multivariable analysis, and generalized additive models (GAM) to investigate the relationship between urinary nitrate and PSA. Subgroup analyses were conducted to further validate the stability of this association across different groups. GAM was utilized to provide a more intuitive representation of the specific relationships between PSA and urinary nitrate.</p><p><strong>Results: </strong>TPSA, FPSA, and the prostate specific antigen ratio (%, 4 ng/mL ≤ TPSA ≤ 10 ng/mL) showed negative correlations with urinary nitrate. After adjusting for confounders, only the prostate-specific antigen ratio maintained a significant negative association (β = -632.7; 95% CI: -1094.9, -170.6; P = 0.011), while correlations with TPSA and FPSA were not statistically significant. A nonlinear relationship was observed, where urinary nitrate initially remained stable or changed minimally before gradually declining.</p><p><strong>Conclusion: </strong>This study identifies a negative correlation between urinary nitrate and the prostate-specific antigen ratio in individuals with gray-zone TPSA. These findings enhance our understanding of urinary nitrate's impact and may help reduce overtreatment in this population.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"193"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the impact of lifestyle and demographic factors on DNA fragmentation index (DFI) among infertile men.","authors":"Abayomi Bolaji Ajayi, Victor Ajayi, Kazeem Adewale Osuolale, Ngozi Obi, Roselyn Obasa-Gbadebo, Toluwanimi Balogun, Anuoluwa Alaka, Olaoluwa Musa, Edith Omokhegbele","doi":"10.1186/s12894-025-01883-8","DOIUrl":"10.1186/s12894-025-01883-8","url":null,"abstract":"<p><strong>Background: </strong>Sperm DNA fragmentation detection methods include SCSA, SCD, COMET assay, and TUNEL. In 2021, the DFI test became the first evidence-based sperm DNA integrity test included in international guidelines. However, limited data exists from Nigeria. This study explores the relationship between demographic, lifestyle, and medical factors and DFI among infertility patients at Nordica Fertility Centre, aiming to guide interventions to improve fertility outcomes.</p><p><strong>Methods: </strong>A total of 643 male infertility patients undergoing DFI analysis were evaluated. Participants were categorized based on age, occupation, BMI, alcohol use, smoking habits, and ejaculation frequency. The DFI was assessed both continuously and categorically using a 25% threshold (≤ 25% good, > 25% poor integrity). Chi-square tests examined associations between categorical variables while t-test was also used to examine significant association in terms of mean comparisons between DFI and other variables. Logistic regression analysis, with forward stepwise selection, identified independent predictors of high DFI, adjusting for potential confounders.</p><p><strong>Results: </strong>Participants had a mean age of 44.1 years; 55.7% were under 45. Most were professionals (57.1%) with a mean BMI of 27.5 kg/m². Alcohol use was reported by 45.2% and smoking by 9.6%. Mean DFI was 37.8% (range: 6-93%). Higher DFI was significantly associated with older age (χ²=12.21, p = 0.001), non-professional occupation (χ²=162.75, p < 0.001), and poor sperm motility (χ²=5.724, p = 0.017). Logistic regression showed that age above 45 years (OR = 2.45, 95% CI: 1.39-4.32, p = 0.002), occupation category (Professional/Technical/Managerial/ Clerical) (OR = 0.001, 95% CI: 0.0001-0.011, p < 0.001), and alcohol use (OR = 18.01, 95% CI: 7.03-46.12, p < 0.001) were independently associated with the outcome.</p><p><strong>Conclusion: </strong>Older age, alcohol consumption, Professional/Technical/Managerial/ Clerical occupations, and alcohol use are associated with increased sperm DNA fragmentation. These findings highlight the need for personalized fertility assessments and targeted interventions to enhance male reproductive health.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"198"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant anterior urethral diverticulum with posterior urethral false passage masquerading as incontinence after pelvic fracture urethral injury: a case report.","authors":"Yubo Gu, Zhenghao Dai, Lujie Song","doi":"10.1186/s12894-025-01902-8","DOIUrl":"10.1186/s12894-025-01902-8","url":null,"abstract":"","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"194"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optilume, a minimally invasive solution for BPH and urethral stricture: what we know, what we need? an EAU endourology scoping review.","authors":"Vineet Gauhar, Steffi Kar Kei Yuen, Nariman Gadzhiev, Marcelo Wroclawski, Giacomo Maria Pirola, Ee Jean Lim, Angelo Cormio, Carlo Giulioni, Angelo Cafarelli, Dmitry Enikeev, Yunfu Liu, Jeremy Yuen Chun Teoh, Dean Elterman, Thomas Hermann, Daniele Castellani","doi":"10.1186/s12894-025-01896-3","DOIUrl":"10.1186/s12894-025-01896-3","url":null,"abstract":"<p><strong>Introduction: </strong>Optilume and Optilume BPH, a minimally invasive drug-coated balloon (DCB) combining mechanical dilation with paclitaxel delivery, offers a novel approach for treating urethral strictures and benign prostatic hyperplasia (BPH) respectively. This scoping review summarizes current evidence on their efficacy, safety, and long-term outcomes to evaluate their role in reducing recurrence and improving patient-reported and functional outcomes.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a systematic search (Embase, PubMed, Cochrane, Scopus) until March 2025 identified 287 studies. Eligibility followed PICOS criteria, excluding non-English articles, reviews, and case reports. Risk of bias was assessed using Cochrane RoB 2 and MINORS tools. Data extraction focused on anatomical success, symptom improvement, complications, and retreatment rates. This review was registered at https://osf.io/vf4dw .</p><p><strong>Results: </strong>After screening, 20 studies met inclusion criteria: 2 preclinical animal studies, 12 clinical studies on urethral strictures, and 6 on BPH. For urethral strictures, the ROBUST trials demonstrated 71.7% freedom from reintervention at 5 years, with sustained improvements in peak flow rate (Qmax: 5.0 to 19.9 mL/s) and IPSS (25.2 to 7.2). In BPH, the PINNACLE trial reported a 67.5% responder rate (≥ 30% IPSS improvement) at 2 years, with IPSS reduced from 23.4 to 11.0. Qmax improved from 8.9 to 19.0 mL/s, and sexual function (IIEF scores) remained stable. Safety profiles were favorable, with transient hematuria (15-39.8%) and no severe complications. Cost analyses indicated potential savings due to reduced retreatment.</p><p><strong>Conclusion: </strong>Optilume provides significant symptom relief for BPH and urethral strictures, with low recurrence rates and preserved sexual function. Its minimally invasive nature, combined with targeted drug delivery, positions it as a promising alternative to traditional surgeries. Further research is needed to expand indications and validate long-term outcomes and cost-effectiveness across diverse populations.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"196"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive utility of the E-PASS score for postoperative complications in robot-assisted partial nephrectomy: a retrospective cohort study.","authors":"Cagatay Ozsoy, Erhan Ates, Resat Inal, Mucahit Gelmis, Sahin Kilic, Mutlu Ates","doi":"10.1186/s12894-025-01899-0","DOIUrl":"10.1186/s12894-025-01899-0","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted partial nephrectomy (RAPN) is widely used for small renal tumors and provides favorable oncological and functional outcomes. However, a significant risk of postoperative complications remains a concern. Existing nephrometry scores focus on tumor anatomy but neglect patient-specific and intraoperative factors. The Estimation of Physiologic Ability and Surgical Stress (E-PASS) score, originally developed for gastrointestinal surgery, combines physiological and surgical parameters for the prediction of postoperative risk. This study evaluates the predictive performance of the E-PASS score in RAPN.</p><p><strong>Methods: </strong>This observational study retrospectively analyzed 166 patients who underwent RAPN between March 2015 and September 2024. The preoperative risk score (PRS), surgical stress score (SSS), and comprehensive risk score (CRS) were calculated. Complications developing within 30 days were classified using the Clavien-Dindo system, with Grade 2 or higher events being considered significant. The performance of the CRS in predicting postoperative complications was evaluated via receiver operating characteristic (ROC) curve analysis, while model calibration was assessed by means of a calibration plot. Logistic regression was used to identify independent predictors of postoperative complication risk. Bootstrap resampling was used to estimate 95% confidence intervals.</p><p><strong>Results: </strong>Grade 2 or higher complications occurred in 26 patients (15.7%). CRS was significantly greater in the complication group (p < 0.001). ROC analysis demonstrated good discrimination (AUC: 0.721; 95% CI: 0.629-0.812). A CRS cut-off of 0.083 yielded 76.8% sensitivity and 59.5% specificity. The calibration plot indicated good agreement between predicted and observed probabilities. Multivariate analysis identified CRS (OR: 1.537, p = 0.044), tumor size (OR: 1.048, p = 0.020), and off-clamp surgery (OR: 4.569, p = 0.003) as independent predictors.</p><p><strong>Conclusions: </strong>E-PASS CRS reliably predicts postoperative complications in RAPN and enhances risk stratification by incorporating patient-specific surgical factors. Its integration may assist more personalized perioperative management in urological surgery.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"197"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot single center study in children with enuresis; exploring frequency and charecteristics of monosymptomatic and non-monosymptomatic nocturnal enuresis.","authors":"Serap Ata, Sevim Yener, Duygu Övünç Hacıhamdioğlu","doi":"10.1186/s12894-025-01900-w","DOIUrl":"10.1186/s12894-025-01900-w","url":null,"abstract":"<p><strong>Background: </strong>Identifying clinical features that differentiate monosymptomatic nocturnal enuresis (MNE) from non-monosymptomatic nocturnal enuresis (NMNE) would aid in quick diagnosis, which would foster the introduction of early and appropriate therapeutic care options. The aim of this study is to determine whether patients with nocturnal enuresis have more daytime symptoms than reported in the literature.</p><p><strong>Methods: </strong>In this retrospective study, patients aged 5-18 years who presented with complaints of nocturnal enuresis were evaluated. Patient records were reviewed for age, gender, daytime lower urinary tract symptoms, bladder capacity,family history of enuresis, Dysfunctional Voiding and Incontinence Scoring System scores, and history of urinary infections. MNE and NMNE were defined according to the International Children's Continence Society.</p><p><strong>Results: </strong>A total of 629 patients, with a mean age of 8.6 ± 2.7, were included in the study. Of these, 53.7% were male. MNE was identified in 266 (42.2%) of the patients, with 363 (57.7%) were identified as having NMNE. Among the MNE patients, 65.4% were male, while 54.8% of the NMNE patients were female (p < 0.001). Patients were divided by age groups in the following manner: 5-7 (n = 272), 8-10 (n = 204), 11-13 (n = 116), and > 14 years old (n = 37). Of all NMNEs, 48.2% were in the 5-7 age group, 28.4% in the 8-10 age group, 16.5% in the 11-13 age group, and 6.9% > 14 age group (p = 0.006). NMNE was identified in 76% of female children aged 5-7 and 55% of males (p < 0.001). The most common lower urinary tract symptoms were daytime urinary incontinence (87.1%), which was present in 61.2% of females and 40.8% of males (p = 0.001). History of urinary system infection (17.1%) was more common in the NMNE group than the MNE group (6.4%) (p < 0.001). The frequency of family history was 54.5% in the MNE group and 35.3% in the NMNE group (p < 0.001).</p><p><strong>Conclusion: </strong>This study showed that the majority of participants who presented with nocturnal enuresis had NMNE. Of particular note was the high frequency of NMNE observed in children aged 5-7 and in females.. These observations highlight the necessity of thoroughly questioning the symptoms of the lower urinary system in children with nocturnal enuresis.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"195"},"PeriodicalIF":1.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral self-insertion of foreign body; a peculiar doorway to a psychiatric diagnosis: a case report.","authors":"N Gharbia, M Chakroun, A Hermi, A Gharbia, S Hmouda, H Ayed, A Aissa, A Saadi, M R Ben Slama","doi":"10.1186/s12894-025-01877-6","DOIUrl":"10.1186/s12894-025-01877-6","url":null,"abstract":"<p><strong>Introduction: </strong>Self-insertion of foreign bodies into the genitourinary tract is a rare but critical emergency, often underreported due to patient embarrassment. Such presentations may mask underlying psychiatric disorders, including acute psychotic episodes. This case report highlights a unique instance of urethral self-insertion of a plastic and metallic cable, which ultimately led to the diagnosis of schizophrenia.</p><p><strong>Case presentation: </strong>A 32-year-old man with no prior medical or psychiatric history presented with acute penile pain of three hours' duration. On examination, the patient remained calm, and a plastic cable was visibly protruding from the urethral meatus. A plain pelvic X-ray revealed a 9-cm radio-opaque foreign body along the urethral tract. After administering tetanus prophylaxis, the foreign bodies were successfully extracted under local anesthesia. Postoperatively, the patient experienced only mild urethrorrhagia and resumed normal urination. Given the unusual nature of the self-injurious behavior, a psychiatric evaluation was performed, which revealed an acute psychotic episode leading to a diagnosis of schizophrenia.</p><p><strong>Conclusion: </strong>This case underscores the necessity for prompt urological intervention to prevent complications such as infection and urethral strictures, as well as the importance of thorough psychiatric evaluation in patients presenting with self-insertion injuries. A multidisciplinary approach integrating both acute physical management and long-term psychiatric care is essential to optimize outcomes and prevent recurrence.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"191"},"PeriodicalIF":1.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of ultrasound-guided \"tract without bleeding vessel requiring embolization (TBVE)\" in reducing bleeding during percutaneous nephrolithotomy.","authors":"Zhipeng Wang, Lei Zhang, Liangwei Wan, Chen Wang, Xiaoqiang Liu, Jun Deng","doi":"10.1186/s12894-025-01891-8","DOIUrl":"10.1186/s12894-025-01891-8","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of ultrasound-guided tract without bleeding vessel requiring embolization (TBVE) versus conventional minimally invasive access in mini-percutaneous nephrolithotomy (Mini-PCNL) for reducing postoperative bleeding.</p><p><strong>Methods: </strong>This retrospective study analyzed 188 patients who underwent Mini-PCNL by a single surgeon between June 2021 and July 2023. Patients scheduled for mini-PCNL were assigned to two groups based on access technique. The first group had no TBVE (Standard mini-PCNL, n = 95) and the second group had TBVE (TBVE-assisted Standard mini-PCNL, n = 93). Baseline characteristics-including gender, age, body mass index (BMI), stone location, stone size, and preoperative hemoglobin levels-were balanced (P > 0.05). Perioperative outcomes were compared using t-tests and χ² tests.</p><p><strong>Results: </strong>The TBVE-assisted mini-PCNL showed superior hemorrhage control, with significantly higher postoperative hemoglobin levels (111.32 ± 24.36 g/L vs. 120.13 ± 15.27 g/L, P < 0.05), smaller 24-hour hemoglobin declines (16.23 ± 15.27 g/L vs. 8.30 ± 7.21 g/L, P < 0.05), and fewer embolization-requiring events (6 vs. 1 case; P < 0.05). Operative time was comparable between groups (Mini-PCNL: 65.42 ± 34.97 min vs. TBVE: 67.73 ± 32.02 min, P > 0.05).</p><p><strong>Conclusion: </strong>TBVE significantly reduces the risk of bleeding in Mini-PCNL compared to conventional access, as evidenced by reduced hemoglobin loss and fewer embolization requirements, without significantly prolonging operative time. This technique enhances procedural safety in the management of complex renal calculi.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"192"},"PeriodicalIF":1.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of inflammatory marker PLR in prostate cancer.","authors":"Junhao Sun, Yu Song, Yunfei Tan, Limin Ma, Huyang Xie","doi":"10.1186/s12894-025-01882-9","DOIUrl":"10.1186/s12894-025-01882-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the correlation between inflammatory markers and prostate cancer with a good-quality predictive model.</p><p><strong>Methods: </strong>The original dataset was randomly split into a training set (70%) and a validation set (30%). Logistic regression was used to examine the related risk factors within the training set. ROC curve analysis was conducted to evaluate the discriminative ability of risk factors for PCa. The accuracy and performance of the prediction model were evaluated using the clinical decision curve and 10-fold cross-validation. The diagnostic value of the model was compared across various PSA regions in the entire dataset. The nomogram was employed to illustrate the predictive model. Additionally, we analyzed the corresponding variables and the relationship between the International Society of Urological Pathology (ISUP) grading of PCa.</p><p><strong>Results: </strong>Age, prostate volume (PV), total PSA (tPSA), (f/t) PSA, and platelet-to-lymphocyte ratio were identified as independent risk factors for prostate cancer. The predictive model utilizing these parameters has shown significant clinical advantage, stability, and elevated diagnostic efficacy within the PSA range of 4-20 ng/mL. Additionally, significant differences in tPSA and PV were observed among PCa patients with varying ISUP grades.</p><p><strong>Conclusion: </strong>PLR can serve as a predictive indicator for prostate cancer and, when integrated with additional clinical data, can enhance the detection rate of prostate cancer. Moreover, there was no correlation between PLR and the ISUP grade of PCa.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"188"},"PeriodicalIF":1.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}