BMC Urology最新文献

{"title":"Exploring dysfunctional voiding in girls: a comprehensive literature review of assessment and management strategies.","authors":"Maryam Sadeghi, Iman Menbari Oskouie, Alvand Naserghandi, Alireza Arvin, Masoumeh Majidi Zolbin","doi":"10.1186/s12894-025-01772-0","DOIUrl":"https://doi.org/10.1186/s12894-025-01772-0","url":null,"abstract":"<p><p>Dysfunctional voiding (DV) is a multifactorial functional problem that refers to dysfunction during voiding. DV is clinically important because it increases the risk of urinary tract infections, mostly due to incomplete bladder emptying, and unfavorably affects renal function. Additionally, a child with DV may experience storage symptoms such as frequency and wetting, which can significantly impact the child's quality of life. There is also a correlation between DV with bowel dysfunction and behavioral disorders. Girls with external urethral meatus anomalies, like hypospadias and/or meatal web, are more prone to complications related to DV. Therefore, girls exhibiting DV symptoms should also be evaluated for meatus anomalies. These patients often contract their external urethral sphincter and pelvic floor musculature, leading to voiding problems. Successful treatment involves applying appropriate diagnostic approaches. In girls with DV, urotherapy and biofeedback are considered gold standard modalities for retraining pelvic floor muscle function synchronously and properly. Although new emerging techniques such as stem cell therapy could improve urinary incontinence in adults and animal models with damaged external urethral sphincters, there is currently a lack of evidence regarding its therapeutic potential for children with DV.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"87"},"PeriodicalIF":1.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced stone-free rates with suctioning ureteral access sheath vs. traditional sheath in retrograde intrarenal surgery: a systematic review and meta-analysis.","authors":"Felipe Giraldo Alvarez Gonçalves, Breno Cordeiro Porto, Bruno Damico Terada, João Victor Gruner Turco Spilborghs, Carlo Camargo Passerotti, Rodrigo A S Sardenberg, Jose Pinhata Otoch, Jose Arnaldo Shiomi Da Cruz","doi":"10.1186/s12894-025-01775-x","DOIUrl":"https://doi.org/10.1186/s12894-025-01775-x","url":null,"abstract":"<p><strong>Background: </strong>As a safe approach to the upper urinary tract, flexible ureteroscopic lithotripsy (fURL) is a widely accepted treatment for nephrolithiasis. Sometimes, this technique can rely on the natural expulsion of stones, increasing the risk of infections and stone recurrence. To mitigate these issues, some studies tried to use a suctioning ureteral access sheath (S-UAS).</p><p><strong>Methods: </strong>A systematic review was conducted across multiple databases for trials comparing S-UAS with traditional (T-UAS) in retrograde intrarenal surgery (RIRS). The primary endpoint was the stone-free rate (SFR), while adverse effects, operative time, fever rate, and hospital stay were analyzed as secondary outcomes.</p><p><strong>Results: </strong>We retrieved 8 articles, encompassing a total of 2,255 patients, with 978 in the S-UAS group and 1,247 in the T-UAS group. Our analysis revealed a higher SFR in the S-UAS group after 1 day, and also at later time points (one or three months) (OR 3.79; 95% CI 1.70-8.46; p = 0.001; I² = 89.2%) and (OR 1.98; 95% CI 1.52-2.59; p < 0.001; I² = 0%), respectively. Regarding surgical complications, we observed a lower incidence in the S-UAS group (OR 0.37; 95% CI 0.26-0.51; p < 0.001; I² = 0%), as well as a reduced fever rate (OR 0.34; 95% CI 0.24-0.48; p < 0.001; I² = 0%) and a shorter length of hospital stay (MD -0.11; 95% CI -0.16 to -0.05; p < 0.001; I² = 39.6%). No differences were found in the operative time between both approaches (MD -2.49; 95% CI -7.62-2.65; p < 0.343; I² = 88.3%).</p><p><strong>Conclusion: </strong>Our study suggests that using S-UAS in RIRS may enhance the SFR, and also reduce both complications and hospital stay.</p><p><strong>Trial registration: </strong>This systematic-review and meta-analysis was prospectively registered on PROSPERO under protocol CRD42024543084.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"86"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stapled vs. manually sutured bowel anastomosis in robot-assisted radical cystectomy: a single-center retrospective analysis.","authors":"Thomas Hermans, Giel Schevenels, Steve Motmans, Thomas De Sutter, Yannic Raskin","doi":"10.1186/s12894-025-01763-1","DOIUrl":"https://doi.org/10.1186/s12894-025-01763-1","url":null,"abstract":"<p><strong>Background: </strong>Radical cystectomy is the primary treatment for muscle-invasive bladder cancer and certain cases of high-risk non-muscle-invasive disease. Robot-assisted cystectomy techniques (RARC) have emerged as a minimally invasive alternative to traditional open surgery, offering enhanced precision and potentially improved recovery. Bowel anastomosis remains a critical step in these procedures, with manually sutured anastomosis offering a cost-effective alternative to the standard stapled technique. However, concerns remain regarding its impact on surgical outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective study of 92 patients who underwent RARC in our hospital between March 2021 and November 2023. Bowel anastomosis was performed using either stapled (n = 33) or manually sutured techniques (n = 59). Key outcome parameters included gastro-intestinal (GI) complications, overall complications, operation duration, length of hospital stay, readmissions, and postoperative recovery metrics.</p><p><strong>Results: </strong>GI complications occurred in 23 patients (25%), with paralytic ileus being the most common (17%). The rates of GI complications were comparable between the manually sutured (27%) and stapled (21%) groups (p = 0.530, odds ratio 1.38). The mean operation duration was 300 min for the sutured group and 313 min for the stapled group (p = 0.124). The median hospital stay was similar at 8 days (p = 0.384) for both groups. Readmission rates were higher in the sutured group (25% vs. 6%, p = 0.022, odds ratio 5.28), but this was predominantly due to non-GI complications.</p><p><strong>Conclusion: </strong>This study indicates that outcomes are comparable between stapled and manually sutured bowel anastomosis in RARC, with no significant increase in overall complications, GI complications, operation duration or hospital stay if using a manually sutured anastomosis. Considering the low cost of manual suturing, this technique seems highly cost-effective and could be considered a viable alternative to existing stapling techniques.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"85"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous nephrolithotomy versus retrograde intrarenal surgery on mid-sized lower calyx stones- a systematic review of last decade.","authors":"Tunahan Ates, Nebil Akdogan, Ismail Onder Yılmaz, Mehmet Gurkan Arıkan, Mutlu Deger","doi":"10.1186/s12894-025-01771-1","DOIUrl":"https://doi.org/10.1186/s12894-025-01771-1","url":null,"abstract":"<p><strong>Background: </strong>To systematically assess the effectiveness and safety of retrograde intrarenal surgery (RIRS) versus percutaneous nephrolithotomy (PCNL) in treating lower pole stones.</p><p><strong>Methods: </strong>PubMed, Ovid MEDLINE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were researched to identify relevant studies up to May 2018. Based on keyword searches, we explored 1972 studies; following screening and eligibility evaluation, 414 studies were removed for various reasons, including 11 possibly relevant studies for this systematic review. A total of 1342 patient data were interpreted (PCNLn = 688; RIRS n = 654).</p><p><strong>Results: </strong>The stone-free rate (SFR) in ten studies following the PCNL operation varies from 68 to 98.3%, while after the RIRS procedure, it ranges from around 46-93.7%. Out of 10 investigations, 7 demonstrated a superior SFR for the PCNL technique compared to the RIRS. Of the ten investigations, eight demonstrated reduced surgical durations using the PCNL method compared to the RIRS procedure. The duration of hospital stays for the PCNL treatment varies from around 0.3 ± 0.04 to 5.3 ± 1.20 days, while the duration for RIRS procedures ranges from 0 to 3.2 ± 0.52 days. All nine trials indicated a reduced period of hospital stay with the RIRS technique compared to the PCNL procedure. The complication rates in 10 studies following the PCNL surgery varied from approximately 2-72%, while those after the RIRS procedure ranged from about 4-21.6%. Out of 10 trials, 6 demonstrated a reduced complication rate with the RIRS technique compared to the PCNL.</p><p><strong>Conclusion: </strong>The majority of studies in this systematic review indicate that the PCNL method exhibits a superior SFR, reduced operational duration, prolonged hospital stay, and increased complication rates compared to the RIRS procedure.</p><p><strong>Clinical trial number: </strong>Not applicable, as this is a systematic review.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"84"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the chemical composition of urinary calculi in vivo using gray scale ultrasound.","authors":"Ningning Liu, Jing Li","doi":"10.1186/s12894-025-01758-y","DOIUrl":"https://doi.org/10.1186/s12894-025-01758-y","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to preliminarily predict the chemical composition of urinary calculi using ultrasound in vivo.</p><p><strong>Methods: </strong>The data of 267 urinary calculi patients were analyzed retrospectively, including non-contrast computed tomography (NCCT) and ultrasound imaging data before the intervention and post-interventional chemical composition. The Hounsfield unit (HU) value of calculi, the grayscale value of calculi and the grayscale value of posterior acoustic shadow of calculi on ultrasound were measured and analyzed statistically.</p><p><strong>Results: </strong>The chemical composition analysis indicated that there were four types of mixed calculi; the main components were whewellite calculi, weddellite calculi, carbonate apatite calculi and anhydrous uric acid calculi. The HU value could distinguish between calcium-containing calculi and anhydrous uric acid calculi, with a cut-off value of 644.00, a sensitivity of 88.00% and a specificity of 95.04%, and P < 0.001. The grayscale value of calculi on ultrasound could distinguish between calcium-containing calculi and anhydrous uric acid calculi with a cut-off value of 200.29, a sensitivity of 38.84% and a specificity of 96.00%, P < 0.001. The grayscale value of the posterior acoustic shadow of calculi on ultrasound could distinguish between carbonate apatite calculi and anhydrous uric acid calculi with a cut-off value of 31.48, a sensitivity of 58.33% and a specificity of 84.00%, and P = 0.011.</p><p><strong>Conclusion: </strong>Ultrasound can preliminarily distinguish the chemical composition of urinary calculi and provide certain information for clinicians to choose treatment plans.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"83"},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot metabolomics study on clear cell renal cell carcinoma.","authors":"Ying Gan, Zheng Li, Mingjian Ruan, Yang Yang","doi":"10.1186/s12894-025-01767-x","DOIUrl":"https://doi.org/10.1186/s12894-025-01767-x","url":null,"abstract":"<p><p>Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. To investigate the underlying metabolite changes in the occurrence of ccRCC, we analyzed untargeted metabolomics of 15 ccRCC samples and paired adjacent non-malignant renal tissues by UHPLC-MS/MS analyses. In this study, 511 differential metabolites were screened, of which the top ten up-regulated metabolites in ccRCC were histamine, 1-methylnicotinamide, L-kynurenine, cortisol, tetrahydrocorticosterone, calcitriol, D-erythrose 4-phosphate, citric acid, sedoheptulose 1,7-bisphosphate, and UDP-alpha-D-galactose, and the top down-regulated metabolites were D-cysteine, acetylcholine, pantothenic acid, cytosine, UMP, biocytin, dUMP, 5-phosphoribosyl 1-pyrophosphate, cytidine-5'-monophosphate, and 16α-hydroxyestrone. KEGG pathways enrichment analysis further demonstrated several highlighted pathways: steroid hormone biosynthesis, pyrimidine metabolism, and vitamin digestion and absorption. Our study reveals metabolic patterns of ccRCC and provides insight into the potential biomarker panel to diagnose ccRCC.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"82"},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of hyperthermic intravesical chemotherapy using pirarubicin and Bacillus Calmette-Guérin in the treatment of patients with high-risk non-muscle-invasive bladder carcinoma: a retrospective study.","authors":"Zhilong Huang, Shibo Huang, Eran Wu, Qinghua He, Xuedong Wei, Weiming Liang","doi":"10.1186/s12894-025-01773-z","DOIUrl":"https://doi.org/10.1186/s12894-025-01773-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate and compare the effectiveness and safety of hyperthermic intravesical chemotherapy (HIVEC) utilizing pirarubicin (THP) and Bacillus Calmette-Guérin (BCG) in the treatment of individuals diagnosed with high-risk non-muscle-invasive bladder cancer (NMIBC).</p><p><strong>Materials and methods: </strong>This study was a retrospective study that combined a review of medical records with an outcomes management database. A total of 48 patients who received HIVEC with THP and 43 patients who received BCG treatment following transurethral resection of bladder tumors (TURBT) were found between January 2017 and December 2020. Recurrence-free survival (RFS), progression-free survival (PFS), overall survival (OS) and adverse events (AEs) were evaluated.</p><p><strong>Results: </strong>The baseline features of the HIVEC group (n = 48) and the BCG group (n = 43) were evenly matched. The median duration of follow-up was 61.0 ± 14.5 months. RFS at 1, 2, 3, 4, and 5 years of the BCG group and the HIVEC group were (90.76%, 76.54%, 58.07%, 51.14%, 45.05% vs. 98.04%, 79.53%, 62.46%, 55.93%, 50.03%, p = 0.58). PFS at 1, 2, 3, 4, and 5 years were (97.77%, 85.85%, 81.01%, 74.26%, 67.36% vs. 100.00%, 89.57%, 83.05%, 76.68%, 73.68%, p = 0.53). OS at 1, 2, 3, 4, and 5 years were (100.00%, 100.00%, 90.64%, 88.47%, 83.43% vs. 100.00%,100.00%,97.81%, 96.08%, 90.40%, p = 0.45). The overall incidence and severity of AEs related to the therapy were comparable in both groups.</p><p><strong>Conclusion: </strong>HIVEC with THP offered a satisfactory safety profile and similar effectiveness to BCG. Our findings suggest that it may be regarded as a viable supplementary treatment for high-risk NMIBC patients when there is a shortage of BCG.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"81"},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcome of radiation therapy for locoregional recurrence of upper tract urothelial carcinoma after nephroureterectomy.","authors":"Ho-Hsiang Chang, Hao-Lun Luo, Yu-Li Su, Fu-Min Fang, Chong-Jong Wang, Chun-Chieh Huang","doi":"10.1186/s12894-025-01766-y","DOIUrl":"https://doi.org/10.1186/s12894-025-01766-y","url":null,"abstract":"<p><strong>Background: </strong>The objective was to evaluate the survival outcomes associated with radiation therapy (RT) in cases of postoperative locoregional recurrence of upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).</p><p><strong>Methods: </strong>A total of 30 patients undergoing RT for local or regional recurrence of UTUC after RNU from 2002 to 2017 were enrolled. The median follow-up time for patients who survived was 5.9 years. The application of RT comprised two intents: (1) salvage RT for patients who did not respond to chemotherapy or who did not receive chemotherapy, and (2) consolidation RT for patients who showed complete or partial response to chemotherapy. Overall survival (OS) since recurrence, locoregional progression-free survival (LRPFS) after RT, and distant metastasis-free survival (DMFS) after RT were evaluated. Univariate Cox regression analysis was applied.</p><p><strong>Results: </strong>The median OS since recurrence was 40.0 months, and the 5-year OS, LRPFS, and DMFS rates were 46.6%, 45.0%, and 36.7%, respectively. For 14 patients who underwent salvage RT, the 5-year OS, LRPFS, and DMFS rates were 28.6%, 21.4%, and 21.4%, respectively; for 16 patients undergoing consolidation RT, those rates were 63.5%, 65.8%, and 50.0%, respectively. In univariate analysis, consolidation RT and primary site in the ureter were significant prognostic factors for better OS and LRPFS; an age ≤ 60.0 years was also a significant factor for OS. There was no significant factor for DMFS.</p><p><strong>Conclusions: </strong>The patients undergoing RT for postoperative locoregional recurrence of UTUC had promising survival outcomes. Future prospective randomized trials to verify the findings are needed.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"80"},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective feasibility study to differentiate sacral neuromodulation lead electrode configurations using motor and sensory thresholds and locations of sensation.","authors":"Tianyu He, Christopher Hornung, Michael D Evans, Stephanie J Zoghbi, Leya A Chahine, Fatima A Nazar, Dwight E Nelson, Nissrine Nakib","doi":"10.1186/s12894-025-01724-8","DOIUrl":"10.1186/s12894-025-01724-8","url":null,"abstract":"<p><strong>Background: </strong>Accurate positioning and programming of sacral neuromodulation (SNM) relies upon the use of several intraoperative and postoperative stimulation measurements. While the clinical utility of these acute measurements including pelvic floor motor thresholds (PFMT), toe/leg motor thresholds (TMT), and sensory thresholds (ST), are widely accepted, their usefulness in quantitative research remains unclear. The purpose of this prospective study was to test these measurements and gauge their utility in future research.</p><p><strong>Methods: </strong>Eight participants received Axonics SNM, 6 Medtronic Interstim II, and 2 Medtronic Micro SNM. PFMT was measured after implantation. ST and the location of sensation (LOS) were measured immediately postoperatively (PO), at pre-release from the surgery center (PR), and during a follow-up clinic visit (FU). Thresholds were compared across contact and time using linear mixed-effects models.</p><p><strong>Results: </strong>Significant differences in PFMT were found across electrode configurations, with stimulation through proximal contacts exhibiting lower PFMT than distal configurations. ST displayed no significant differences across electrodes and showed minimal changes over time. LOS exhibited substantial variability across patients and periods.</p><p><strong>Conclusions: </strong>Results suggest that PFMT were able to differentiate differences across electrode configurations that may be useful for future quantitative research. The lack of differences in ST and LOS across electrode configurations was interesting given the focus on these measurements clinically. Future testing is to confirm these limitations.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"79"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between novel inflammatory markers and overactive bladder: a cross-sectional study of NHANES 2009 to 2018.","authors":"Liangwei Wan, Zhipeng Wang, Lei Zhang, Chen Wang, Lianmin Luo, Xiaoqiang Liu, Jun Deng","doi":"10.1186/s12894-025-01743-5","DOIUrl":"10.1186/s12894-025-01743-5","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate the relationship between Overactive Bladder (OAB) and inflammatory markers, including the Systemic Immune-Inflammation Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Systemic Inflammation Response Index (SIRI).</p><p><strong>Methods: </strong>This cross-sectional study drew upon data from the National Health and Nutrition Examination Survey (NHANES) spanning the 2009-2018 cycles, including 19,194 participants, with OAB identified using the Overactive Bladder Symptom Score (OABSS) based on survey responses. Multivariate logistic regression and restricted cubic spline (RCS) analyses were employed to evaluate the association between these markers and OAB. Subgroup analysis is used to identify potential influencing factors and ensure the robustness of the study results.</p><p><strong>Results: </strong>Multivariate logistic regression analysis indicated notable positive correlations between OAB and SII (Q4 OR = 1.25, 95% CI: 1.06-1.46), NLR (Q4 OR = 1.29, 95% CI: 1.12-1.49), and SIRI (Q4 OR = 1.23, 95% CI: 1.05-1.43), with no significance for PLR. Trend tests showed statistical significance for SII, NLR, and SIRI, but not for PLR. RCS analysis also showed a nonlinear relationship among SII, NLR, SIRI, and OAB. It is noteworthy that age is a key influencing factor in the subgroup analysis. These findings suggest that systemic inflammation may play a crucial role in OAB pathophysiology, and inflammatory markers like SII, NLR, and SIRI could serve as potential indicators for identifying individuals at higher risk of OAB, thereby informing early intervention strategies.</p><p><strong>Conclusion: </strong>SII, NLR, and SIRI are positively associated with OAB, suggesting a potential role of inflammation in its pathogenesis. However, further validation through prospective cohort studies is needed to establish their clinical utility and causal relationship with OAB.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":"25 1","pages":"78"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}