BMC Urology最新文献

{"title":"A case report of pathological complete response in an elderly patient with advanced urothelial carcinoma treated with disitamab vedotin plus toripalimab.","authors":"Liang Songlin, Liu Yunxun, He Peiyu, Hu Wen, Li Mingyong","doi":"10.1186/s12894-026-02194-2","DOIUrl":"10.1186/s12894-026-02194-2","url":null,"abstract":"<p><p>Urothelial carcinoma is a common malignancy of the urinary tract and occurs predominantly in elderly men. Although surgery, chemotherapy, and radiotherapy remain the main treatment options, their efficacy in advanced disease is often limited, particularly in elderly patients with comorbidities or poor surgical tolerance. Antibody-drug conjugates (ADCs) combined with immune checkpoint inhibitors have recently emerged as a promising therapeutic strategy. We report the case of a 79-year-old man with advanced urothelial carcinoma who declined radical cystectomy and received disitamab vedotin plus toripalimab. Histopathological examination confirmed high-grade muscle-invasive urothelial carcinoma, and supplementary immunohistochemistry showed HER2 expression of 1+. FISH/ISH and PD-L1 testing were not performed. The patient received treatment every 3 weeks over 2 consecutive days, with disitamab vedotin on day 1 and toripalimab on day 2. After 6 cycles, imaging showed marked tumor regression, and repeat transurethral resection of the tumor bed revealed no residual tumor cells, consistent with pathological complete response. The treatment was generally well tolerated, with only mild fatigue and nausea. This case suggests that disitamab vedotin combined with toripalimab may have activity in selected patients with advanced urothelial carcinoma, including those with low HER2 expression. However, the findings should be interpreted cautiously, and further studies are needed to clarify the role of this regimen and the value of predictive biomarkers.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of transcutaneous tibial nerve stimulation (TTNS) versus solifenacin in female patients with overactive bladder.","authors":"MohammadJavad Safaie Yazdi, Salman Nazary-Moghadam, Bagher Soleimani, Seyyed Parham Ahmadi, Fatemeh Sadabadi, Zhila Sheikhi","doi":"10.1186/s12894-026-02222-1","DOIUrl":"10.1186/s12894-026-02222-1","url":null,"abstract":"<p><strong>Background: </strong>Overactive bladder (OAB) is commonly managed with antimuscarinic agents, although tolerability limits long-term adherence. Tibial nerve stimulation (TNS) has emerged as a non-pharmacologic alternative. This study compared the efficacy and safety of TNS versus solifenacin in women with OAB.</p><p><strong>Methods: </strong>In this randomized controlled clinical trial, 118 patients met OAB diagnostic criteria, who presented to Qaem Hospital (Mashhad, Iran, 2023). Participants were randomly assigned to receive 12 weeks of either TNS (two 30-minute sessions weekly) or oral solifenacin (5 mg daily). Primary outcomes included changes in OAB symptom severity, urinary incontinence, and quality of life scores, using validated questionnaires at baseline and week 12. Statistical analysis was conducted using SPSS version 22, with significance set at p < 0.05.</p><p><strong>Results: </strong>Both treatments led to significant improvement in OAB symptoms, urinary incontinence severity, and quality of life (all p < 0.001). TNS produced slightly greater improvement in OAB symptom severity (p = 0.016) and significantly greater reduction in urinary incontinence severity (p = 0.015). Quality of life improved substantially in both groups (p < 0.001), with comparable post-treatment scores. Adverse effects occurred in 88.1% of solifenacin users, whereas no side effects were reported with TNS.</p><p><strong>Conclusion: </strong>TNS is an effective and well-tolerated treatment for OAB, offering superior improvement in urinary incontinence and a markedly better safety profile compared with solifenacin. TNS may represent a preferable non-pharmacologic alternative for patients who cannot tolerate or do not respond adequately to anticholinergic medications. Future studies with larger cohorts and extended follow-up durations would be beneficial to validate and expand upon our findings.</p><p><strong>Trial registration: </strong>The study protocol was officially registered in the Iranian Registry of Clinical Trials under the identifier IRCT20190618043934N25 on 2024-05-13.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality, content structure, and reliability of prostatitis-related information on short-video platforms: a cross-platform analysis of TikTok and Bilibili.","authors":"Pan Ding, Qinghua Luo, Leihua Cao","doi":"10.1186/s12894-026-02225-y","DOIUrl":"10.1186/s12894-026-02225-y","url":null,"abstract":"<p><strong>Background: </strong>Prostatitis, particularly chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), remains a common yet challenging condition in urological practice, largely due to its heterogeneous etiology, diagnostic complexity, and high levels of patient anxiety. Increasingly, patients seek information about prostatitis from short-video platforms; however, the quality and clinical relevance of such content remain unclear.</p><p><strong>Methods: </strong>A cross-sectional content analysis was conducted to evaluate prostatitis-related videos on TikTok and Bilibili. Video characteristics, engagement metrics, uploader type, and content themes were extracted. Information quality and reliability were assessed using the Global Quality Scale (GQS) and the modified DISCERN (mDISCERN) instrument, while content completeness was evaluated using a six-domain clinical information framework. Comparisons were performed across platforms and uploader categories, and correlations between engagement metrics and quality indicators were analyzed.</p><p><strong>Results: </strong>A total of 223 videos were included. Overall information quality and reliability were moderate. Content distribution was heavily skewed toward treatment-related information, whereas disease awareness, diagnostic principles, and preventive or long-term management content were markedly underrepresented. Videos uploaded by healthcare professionals demonstrated significantly higher quality, reliability, and content completeness than those from non-professional sources. TikTok videos achieved higher overall quality and reliability scores compared with Bilibili. Engagement metrics showed only weak correlations with information quality and reliability indicators.</p><p><strong>Conclusion: </strong>Prostatitis-related information on short-video platforms is characterized by moderate quality and substantial structural imbalance, with an overemphasis on treatment and insufficient coverage of diagnostic reasoning and long-term management. From a urological clinical perspective, incomplete or misleading online information may shape patient expectations and has the potential to complicate clinical communication and shared decision-making, particularly regarding diagnostic evaluation, antibiotic expectations, and long-term management. Greater involvement of urologists in structured digital patient education and the promotion of clinically accurate content are needed to mitigate misinformation and improve patient understanding.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted urinary sodium excretion and urolithiasis risk: a two-sample mendelian randomization study.","authors":"Dakun Huang, Haixin Li, Shudong Yang","doi":"10.1186/s12894-026-02219-w","DOIUrl":"10.1186/s12894-026-02219-w","url":null,"abstract":"<p><strong>Background: </strong>High sodium intake has been linked to kidney stone formation in many observational studies, but these findings may be influenced by dietary habits and fluid intake. Whether urinary sodium itself plays a causal role in urolithiasis remains unclear.</p><p><strong>Methods: </strong>We performed a two-sample Mendelian randomization analysis to examine the association between urinary sodium excretion and urolithiasis risk. Genetic instruments for urinary sodium were obtained from large genome-wide association studies based on the UK Biobank and EBI databases (N > 300,000). Summary statistics for urolithiasis were derived from the FinnGen R12 dataset. The primary analysis was conducted using the inverse variance weighted method, with additional sensitivity analyses including MR-Egger, weighted median, and MR-PRESSO.</p><p><strong>Results: </strong>Higher genetically predicted urinary sodium excretion was associated with an increased risk of urolithiasis (IVW OR = 2.49, 95% CI: 1.45-4.29, P= 0.00099). Similar results were observed in an independent replication dataset (OR = 2.66, 95% CI: 1.39-5.07, P= 0.0029). There was no evidence of horizontal pleiotropy (MR-Egger intercept P= 0.523), and heterogeneity was low. MR-PRESSO did not detect any significant outliers.</p><p><strong>Conclusions: </strong>Our findings provide supportive genetic evidence suggesting that higher urinary sodium excretion may contribute to an increased risk of urolithiasis. These results align with current recommendations for dietary sodium restriction in stone prevention.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between fibrinogen-albumin ratio and erectile dysfunction: a retrospective cross-sectional study.","authors":"Ahmet Yuce, Erdal Benli, Ayhan Arslan, Ahmet Anil Acet, Akin Ayaz, Abdullah Cirakoglu","doi":"10.1186/s12894-026-02221-2","DOIUrl":"10.1186/s12894-026-02221-2","url":null,"abstract":"<p><strong>Objective: </strong>The fibrinogen-to-albumin ratio (FAR) is a new marker used in inflammatory processes and is effective in demonstrating associated microvascular damage. The aim of this study was to evaluate the relationship between FAR and erectile dysfunction (ED), a sexual intercourse disorder associated with inflammatory processes and endothelial dysfunction.</p><p><strong>Methods: </strong>Data from 1876 patients presenting with ED between January 2020 and 2025 were evaluated. A total of 424 patients, 214 in the ED group and 210 in the control group, were included in the study. Anthropometric measurements and biochemical examinations of the patients were recorded. FAR values were compared between the ED group, ED subgroups, and the control group. The cut-off value for the FAR value and the potential correlation between ED severity were examined.</p><p><strong>Results: </strong>The FAR value was calculated as 89.4 ± 27.3 in the ED group and 67.8 ± 18.8 in the control group (p < 0.001). The optimal cut-off value for FAR was found to be 101.49 with 33% sensitivity and 99% specificity. FAR values were significantly higher in the ED subgroups compared to the control group. A moderate linear correlation was found between IIEF-5 scores and FAR values (r = -0.554, p < 0.001). The FAR value (AUC = 0.724) was found to be more successful in distinguishing between diseased and healthy individuals than CAR (AUC = 0.647), a similar inflammatory marker.</p><p><strong>Conclusion: </strong>It has been shown that FAR is significantly associated with the presence and severity of ED and can be a reliable and easily accessible marker to support the diagnosis of ED.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, anxiety, and health related quality of life following radical prostatectomy and radiation treatment: 12 month outcomes in a South African cohort.","authors":"Hayley Irusen, Pedro Fernandez, Tonya Esterhuizen, Andre van der Merwe, Pieter Spies, Soraya Seedat","doi":"10.1186/s12894-026-02174-6","DOIUrl":"10.1186/s12894-026-02174-6","url":null,"abstract":"<p><strong>Purpose: </strong>Longitudinal patient-reported outcomes comparing radical prostatectomy (RP) and radiation (RT) for localized prostate cancer (CaP) in low- to middle- income countries are limited. We examined the comparative course of depression and anxiety and their association with health related quality of life (HRQOL) in men treated with RP or RT over a year post-treatment.</p><p><strong>Methods: </strong>Data from 161 South African (SA) men with CaP were analysed. Depression, Anxiety, HRQOL, and relevant covariates were measured at baseline, 3, 6, 9, and 12 months. We used the following validated scales: Centre for Epidemiologic Studies Depression (CES-D), State Trait Anxiety Inventory (STAI-S), European Organisation for Research and Treatment in Cancer Quality of Life (EORTC QLQ-PR25), Multidimensional Scale of Perceived Social Support (MSPSS), Memorial Anxiety Scale for Prostate Cancer (MAX-PC), Connor-Davidson Resilience Scale (CD-RISC), and Decisional Conflict Scale (DCS).</p><p><strong>Results: </strong>Depressive symptoms (CES-D ≥ 16) remained elevated 12 months post-RP (baseline: 43%; 3-month: 37%; 6-month: 47%; 12-month: 42%), while RT prevalence declined (39% to 29%). Similarly, anxiety (STAI-S ≥ 39) was more prevalent and persistent in the RP group (29% to 23%; 6-month peak: 28%) compared to the RT group (26% to 15%), where scores consistently declined throughout the first year. Overall urinary morbidity was marked in the first six months (β = 11.828; 95% CI: 7.931to 15.73; p < 0.001). More men in the RP group exhibited higher incontinence aids use (β = -21.477; 95% CI: to 33.261 to 9.694; p < 0.001). Sexual function in RP was lower (β = 18.006; 95% CI: 6.881 to 29.131; p = 0.002) with increased sexual activity from month nine onwards (β = -13.203; 95% CI: -23.489 to -2.916; p = 0.012). RT was associated with bowel symptoms in the latter half of follow-up. (4.681; 95% CI: 0.702 to 8.659; p = 0.021). Depression and anxiety adversely affected all HRQOL functional and symptom domains except sexual activity.</p><p><strong>Conclusion: </strong>The high prevalence of depression and anxiety reflects marked psychological morbidity in men treated for CaP in the first year post-treatment. Given the substantial association between psychological impairment and HRQOL, integrating mental health screening, management and referral into uro-oncology protocols is critical.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of music intervention on anxiety and pain after anatomical endoscopic enucleation of the prostate: a prospective randomized controlled trial.","authors":"Irfan Safak Barlas, Mehmet Yilmaz, Halil Cagri Aybal, Mehmet Duvarci, Selcuk Guven, Lutfi Tunc","doi":"10.1186/s12894-026-02223-0","DOIUrl":"10.1186/s12894-026-02223-0","url":null,"abstract":"<p><strong>Background: </strong>This prospective randomized study aimed to assess the effect of self-selected music, delivered via loudspeaker, on early postoperative anxiety and pain in patients who underwent anatomical endoscopic enucleation of the prostate (AEEP) under spinal anesthesia without sedation.</p><p><strong>Methods: </strong>Adult male patients scheduled for AEEP were randomly allocated to either a music intervention group (self-preferred music) or a control group (no music). Baseline characteristics, preoperative urethral catheter status, International Prostate Symptom Scores (IPSS), operative duration, and pre- and postoperative anxiety scores (State Anxiety Inventory, SAI) were recorded. Visual Analog Scale (VAS) was used to evaluate postoperative pain two hours after surgery.</p><p><strong>Results: </strong>A total of 135 patients were analyzed (music group, n= 67; control group, n= 68). Baseline characteristics and operative times were comparable between groups (p>0.05). The music group had significantly lower postoperative SAI (32.0 ± 7.32 vs. 38.38 ± 11.28; p = 0.001) and VAS scores (1 [1-2] vs. 2 [1-3]; p = 0.001). The reduction in postoperative SAI compared to preoperative value was also greater in the music group (14 [10.00-21.00] vs. 7 [1.00-11.75]; p = 0.001). Music type had no significant impact on outcomes (p>0.05). In multivariate analysis, music intervention and preoperative catheterization were independent predictors of postoperative anxiety.</p><p><strong>Conclusions: </strong>Self-selected music intervention significantly reduced early postoperative anxiety and pain following AEEP under spinal anesthesia. Given its simplicity and non-invasive nature, music may serve as an effective adjunct for enhancing patient comfort, regardless of music genre.</p><p><strong>Clinical trial number: </strong>NCT07255118.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13483732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding-related outcomes after transurethral resection of prostate in patients with chronic antiplatelet or anticoagulant therapy following perioperative interruption: a retrospective cohort study.","authors":"Abdullah Ilktac, Bayram Dogan, Cevper Ersoz, Senad Kalkan, Serkan Akıncı, Muzaffer Akcay, Yusuf Ozlem Ilbey","doi":"10.1186/s12894-026-02220-3","DOIUrl":"10.1186/s12894-026-02220-3","url":null,"abstract":"<p><strong>Background: </strong>Transurethral resection of the prostate (TURP) is s the gold standard surgical treatment method for benign prostatic hyperplasia. With the aging population and the increasing prevalence of cardiovascular diseases, the number of patients requiring anticoagulant (AC) or antiplatelet (AP) therapy continues to rise. The perioperative management of these medications remains challenging because continuation may increase bleeding complications, whereas discontinuation may increase thromboembolic risk. In this study, we evaluated bleeding-related outcomes after TURP in patients receiving chronic AP or AC therapy undergoing perioperative medication interruption.</p><p><strong>Methods: </strong>This retrospective study included patients who underwent TURP between January 2020 and December 2024 at our tertiary referral center. Patients were divided into three groups according to their perioperative use of AP and AC medications.</p><p><strong>Control group: </strong>Patients who did not receive any AC or AP therapy. AP group: Patients receiving antiplatelet therapy. AC group: Patients treated with anticoagulants. None of the patients underwent TURP under continued AP or AC therapy. Perioperative and postoperative outcomes, including duration of irrigation, duration of catheterization, length of hospital stay, development of clot retention during hospitalization, need for postoperative blood transfusion, readmission due to hematuria within 30 days, and need for recatheterization or reoperation due to bleeding, were evaluated. A composite bleeding outcome was created to increase statistical power including postoperative blood transfusion, clot retention, and hematuria-related readmission.</p><p><strong>Results: </strong>A total of 325 patients were included: 198 in the control group, 97 in the AP group, and 30 in the AC group. Overall comparisons showed significant differences in postoperative transfusion (p = 0.001) and hematuria-related readmission rates (p = 0.032) between three groups but post-hoc pairwise Fisher's exact tests with Bonferroni correction did not confirm statistical significance between specific pairs. There were no significant differences between the groups in other parameters. Multivariable logistic regression identified antiplatelet therapy as an independent predictor of hematuria-related readmission (OR:4.17, p = 0.010).</p><p><strong>Conclusion: </strong>AP therapy is independently associated with an increased risk of hematuria-related readmission even after perioperative interruption of therapy. Patients receiving antithrombotic therapy should be carefully monitored during the perioperative period, and clinicians should remain vigilant for potential bleeding-related complications.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and preliminary safety of urologic telesurgery using Chinese surgical systems: a single-center exploratory case series.","authors":"Tao Xu, Zixing Wang, Ao Qi, Meiling Guo, Jianwei Wang, Pengyu Guo, Ziqi Wang","doi":"10.1186/s12894-026-02202-5","DOIUrl":"10.1186/s12894-026-02202-5","url":null,"abstract":"<p><strong>Purpose: </strong>Telesurgery offers a solution to the uneven distribution of surgical resources by enabling telesurgery through surgical robotic systems. This study aimed to describe the technical feasibility and preliminary short-term safety of urologic telesurgery using Chinese surgical systems (CSS).</p><p><strong>Methods: </strong>This single-center exploratory descriptive case series evaluated urologic telesurgery using CSS between January 2023 and October 2025. A total of 6 consecutive eligible telesurgeries were included: 3 robot-assisted radical prostatectomies (RARP) and 1 robot-assisted partial nephrectomy (RAPN) were performed with the Edge MP1000 (MP1000) system, and 1 RAPN and 1 robot-assisted radical cystectomy (RARC) were performed with the KangDuo SR-2000 (KD-SR-2000) system. Six locally performed RARP cases using the da Vinci Xi (DV-Xi) system during the same study period were retrospectively collected as a limited contextual reference for the RARP subgroup. The primary outcome was technical success, defined as completion without conversion. Secondary descriptive outcomes included perioperative safety events, 30-day Clavien-Dindo complications (CDC), network performance, and, in the RARP subgroup, positive surgical margin (PSM) rate, estimated blood loss (EBL), operative time, suture-per-stitch time, and 4-week urinary continence recovery after catheter removal.</p><p><strong>Results: </strong>All six telesurgeries were completed without intraoperative conversion or major complications. In the RARP subgroup, remote MP1000 procedures were summarized alongside locally performed DV-Xi procedures as a limited contextual reference. PSM rate and early urinary continence recovery showed no obvious unfavorable signal in this small contextual cohort, whereas operative time and suture-per-stitch time were longer, and EBL was numerically higher, in remote procedures. Mean Network round-trip latency for telesurgery ranged from 6.13 ± 0.71 ms (Harbin-Harbin, 2 km) to 54.12 ± 0.58 ms (Harbin-Hangzhou, 2200 km), with no frame loss.</p><p><strong>Conclusion: </strong>In this small selected case series, urologic telesurgery using CSS was technically feasible and preliminary safety under stable telecommunication conditions.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AirSeal^® versus conventional insufflation in robot-assisted radical prostatectomy: effects on operative efficiency, pain, and perioperative outcomes.","authors":"Ibrahim Can Aykanat, Mustafa Muduroglu, Sevval Kanli Mese, Arif Ozkan, Ahmet Gurbuz, Ersin Koseoglu, Yakup Kordan, Mevlana Derya Balbay, Tarik Esen, Abdullah Erdem Canda","doi":"10.1186/s12894-026-02218-x","DOIUrl":"10.1186/s12894-026-02218-x","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted radical prostatectomy (RARP) requires a stable pneumoperitoneum to maintain optimal surgical conditions. The AirSeal^® Intelligent Flow System has been developed to provide continuous pressure regulation and smoke evacuation; however, its clinical impact during RARP remains incompletely defined.</p><p><strong>Objective: </strong>To compare perioperative, oncological, and postoperative recovery outcomes between the AirSeal system and conventional insufflation systems during RARP.</p><p><strong>Methods: </strong>We retrospectively analyzed patients who underwent RARP at a high-volume tertiary center in a retrospective before-and-after cohort design. Patients were stratified according to the insufflation system used during surgery: conventional insufflation system (CIS) or the AirSeal system. Demographic characteristics, perioperative parameters, pathological outcomes, postoperative complications (Clavien-Dindo), postoperative pain scores and opioid consumption were evaluated.</p><p><strong>Results: </strong>A total of 749 patients were included (CIS: 398; AirSeal: 351). Baseline demographic and clinical characteristics were comparable between the groups. Operative time was significantly shorter in the AirSeal group (183 ± 77.7 vs. 217.4 ± 73.0 min; p < 0.001). Estimated blood loss, transfusion rates, and length of hospital stay were similar between the groups. Pathological stage distribution differed between the groups, with a higher proportion of locally advanced disease (≥pT3) in the AirSeal cohort (49.3% vs 39.2%; p = 0.005). However, other oncological outcomes, including pathological ISUP grade distribution, lymph node involvement, and positive surgical margin rates, were comparable. Overall postoperative complication rates were similar between the groups; however, high-grade complications (Clavien-Dindo ≥III) occurred less frequently in the AirSeal group. Postoperative pain scores at 1, 6, and 24 hours were significantly lower in the AirSeal group (all p < 0.001), postoperative morphine consumption at 24 hours was also significantly reduced (p < 0.001).</p><p><strong>Conclusions: </strong>Use of the AirSeal insufflation system during RARP was associated with shorter operative times, lower postoperative pain scores, and less frequent high-grade complications. Positive surgical margin rates and lymph node involvement were comparable between the groups. However, given the retrospective before-and-after design, differences in surgical periods and pneumoperitoneum pressure between the groups, these findings should be considered observational and hypothesis-generating.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}