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Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis B 组链球菌感染时血清炎症因子的变化及其对并发绒毛膜羊膜炎的胎膜早破的预测价值
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-16 DOI: 10.2217/bmm-2023-0588
Xiaorui Dong, Xixi Chen, Mengling Xue, Yina Zhang
{"title":"Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis","authors":"Xiaorui Dong, Xixi Chen, Mengling Xue, Yina Zhang","doi":"10.2217/bmm-2023-0588","DOIUrl":"https://doi.org/10.2217/bmm-2023-0588","url":null,"abstract":"<p><b>Objective:</b> The aim of this study as to unveil changes in serum inflammatory factors in pregnant women with genital tract group B <i>Streptococcus</i> (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes. <b>Methods:</b> The value of serum inflammatory factor levels in predicting PROM complicating CS and adverse pregnancy outcomes in GBS-infected pregnant women was evaluated by ELISA. <b>Results:</b> Serum IL-6, TNF-α, PCT and hs-CRP levels were higher in pregnant women with GBS infection. The combined diagnosis of these factors had excellent diagnostic value in PROM complicating CS and adverse pregnancy outcomes. <b>Conclusion:</b> Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"82 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients. PLK4 反映了甲状腺乳头状癌患者的甲状腺外侵袭、高肿瘤分期和不良预后。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0565
Xiaonan Hu, Jiawei Yu, Mengshi Chen, Rui Pang
{"title":"PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients.","authors":"Xiaonan Hu, Jiawei Yu, Mengshi Chen, Rui Pang","doi":"10.2217/bmm-2023-0565","DOIUrl":"10.2217/bmm-2023-0565","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to assess the value of PLK4 as a biomarker in papillary thyroid carcinoma (PTC). <b>Methods:</b> This study reviewed 230 PTC patients receiving surgical resections. PLK4 was detected in tumor tissues and samples of normal thyroid gland tissues by immunohistochemistry. <b>Results:</b> PLK4 was elevated in tumor tissues versus normal thyroid gland tissues (p < 0.001). Tumor PLK4 was linked with extrathyroidal invasion (p = 0.036), higher pathological tumor stage (p = 0.030), node stage (p = 0.045) and tumor/node/metastasis stage (p = 0.022) in PTC patients. Tumor PLK4 immunohistochemistry score >3 was linked with shortened disease-free survival (p = 0.026) and overall survival (p = 0.028) and independently predicted poorer disease-free survival (hazard ratio: 2.797; p = 0.040). <b>Conclusion:</b> Tumor PLK4 reflects extrathyroidal invasion, higher tumor stage and shortened survival in PTC.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"169-179"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients. 在多个时间点测量急性缺血性脑卒中患者血浆 LRG1 的预后效力。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0545
Juxian Gu, Chao Liu, Yan Yao
{"title":"Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients.","authors":"Juxian Gu, Chao Liu, Yan Yao","doi":"10.2217/bmm-2023-0545","DOIUrl":"10.2217/bmm-2023-0545","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to investigate the prognostic potency of LRG1 in acute ischemic stroke (AIS) patients. <b>Methods:</b> Plasma LRG1 levels were detected at admission and on days 3, 7 and 30 in 150 AIS patients. <b>Results:</b> LRG1 positively correlated with total cholesterol (p = 0.016), triglycerides (p = 0.046), C-reactive protein (p < 0.001), TNF-α (p = 0.001) and IL-6 (p = 0.004). After admission, LRG1 showed a decreasing trend (p < 0.001). Interestingly, LRG1 levels at admission (p = 0.014), day 3 (p = 0.027), day 7 (p = 0.008) and day 30 (p = 0.002) were higher in patients with modified Rankin scale score ≥2 versus those with scores <2. The LRG1 levels at day 7 (p = 0.032) and day 30 (p = 0.023) were higher in patients with recurrence versus no recurrence. <b>Conclusion:</b> LRG1 correlates with blood lipids, inflammation and short-term prognosis of AIS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"181-190"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction. CDC42和T-辅助细胞比率与ST段抬高型心肌梗死患者的焦虑、抑郁和生活质量的关系。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0712
Xuechao Wang, Junjie Feng, Shaohua Luan, Yong Zhou, Shipan Zhang, Hongling Su, Zhongyu Wang
{"title":"Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction.","authors":"Xuechao Wang, Junjie Feng, Shaohua Luan, Yong Zhou, Shipan Zhang, Hongling Su, Zhongyu Wang","doi":"10.2217/bmm-2023-0712","DOIUrl":"10.2217/bmm-2023-0712","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlations between CDC42 and T-cell subsets concerning anxiety, depression and quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention. <b>Methods:</b> Sera from 156 participants were analyzed for CDC42 levels and Th1, Th2, Th17 and Treg cells. <b>Results:</b> CDC42 correlated with reduced Th1/Th2 and Th17/Treg ratios, lower anxiety and depression, and higher EuroQol visual analog scale (EQ-VAS) score. The Th17/Treg ratio correlated with elevated anxiety, depression, EuroQol-5 dimensions score and decreased EQ-VAS score. The Th1/Th2 ratio was positively related to the EQ-VAS score. <b>Conclusion:</b> CDC42 correlates with reduced Th1/Th2 and Th17/Treg ratios, reduced anxiety and depression, and improved quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"157-168"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenomic biomarkers in coronary artery disease: a narrative review. 冠心病的药物基因组生物标志物：综述。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-08 DOI: 10.2217/bmm-2023-0476
Pamila Dua, Sandeep Seth, Bhavana Prasher, Mitali Mukerji, Subir Kumar Maulik, K H Reeta
{"title":"Pharmacogenomic biomarkers in coronary artery disease: a narrative review.","authors":"Pamila Dua, Sandeep Seth, Bhavana Prasher, Mitali Mukerji, Subir Kumar Maulik, K H Reeta","doi":"10.2217/bmm-2023-0476","DOIUrl":"10.2217/bmm-2023-0476","url":null,"abstract":"<p><p>Coronary artery disease (CAD) has a high mortality rate. Despite various therapeutic targets, non-responsiveness to drugs remains a prevalent issue. Pharmacogenomics assesses the way an individual's genetic attributes affect their likely response to drug therapy. Single-nucleotide polymorphisms play a crucial role in determining these outcomes. This review offers an overview of single-nucleotide polymorphisms investigated in clinical studies and their associations with drug response/nonresponse in the treatment of CAD. A total of 104 studies of whole sets of chromosomes and several genes were explored. A total of 161 polymorphisms exhibited associations with drug response/nonresponse in CAD across diverse ethnic populations. This pool can serve as a pharmacogenomic biomarker for predicting response to drug therapy in patients with CAD.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"191-202"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of HOTAIR lncRNA in the pathogenesis and prognosis of cardiovascular diseases. HOTAIR lncRNA 在心血管疾病的发病机制和预后中的新作用。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.2217/bmm-2023-0368
Habib Haybar, Hakimeh Hadi, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
{"title":"Emerging roles of HOTAIR lncRNA in the pathogenesis and prognosis of cardiovascular diseases.","authors":"Habib Haybar, Hakimeh Hadi, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki","doi":"10.2217/bmm-2023-0368","DOIUrl":"10.2217/bmm-2023-0368","url":null,"abstract":"<p><p>Highlights HOTAIR, a long noncoding RNA, plays a role in the regulation of proteins involved in the pathogenesis of cardiovascular disease. Furthermore, it has been identified as a biomarker of this type of disease. Several factors and cells contribute to atherosclerosis, a progressive disease. However, the prognosis of HOTAIR in this disease varies depending on the path in which it plays a role. For this condition, there is no single prognosis to consider.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"203-219"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of biomarker stability and assay performance parameters for medical diagnosis: a case study of diagnosis of major depressive disorder 用于医学诊断的生物标记物稳定性和检测性能参数评估：重度抑郁障碍诊断案例研究
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-02-02 DOI: 10.2217/bmm-2023-0416
Mike Jentsch, Barry van der Strate, Marjolein Meddens, Marcus Meddens, Robert Schoevers
{"title":"Assessment of biomarker stability and assay performance parameters for medical diagnosis: a case study of diagnosis of major depressive disorder","authors":"Mike Jentsch, Barry van der Strate, Marjolein Meddens, Marcus Meddens, Robert Schoevers","doi":"10.2217/bmm-2023-0416","DOIUrl":"https://doi.org/10.2217/bmm-2023-0416","url":null,"abstract":"<p><b>Aim:</b> Assessing the stability profiles and assay performance of 24 biomarker assays in 32 biomarker/body fluid combinations identified as relevant for prediction of major depressive disorder. <b>Materials &amp; methods:</b> Combinations were tested for stability and assay performance with ELISA at different storage and freeze–thaw conditions in pooled samples of 40 patients. <b>Results:</b> Stability and assay performance issues were found in almost all cases except three biomarkers in urine and three in serum. <b>Conclusion:</b> This study shows that, to produce reliable measurement data, assessments of stability and assay performance are essential. In development, other quality assurance parameters might be implemented to increase the level of measurement reliability by increasing assay performance control.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"8 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139662769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive role of neutrophil-to-platelet ratio in futile recanalization of patients after endovascular therapy. 中性粒细胞与血小板比值对血管内治疗后无效再通畅患者的预测作用。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.2217/bmm-2023-0585
Bing-Hu Li, Li-Rong Wang, Jie Huang, Shu Yang, Bin Huang, Li-Jun Jia, Sen Zhou, Fu-Qiang Guo, Jian-Hong Wang, Neng-Wei Yu
{"title":"Predictive role of neutrophil-to-platelet ratio in futile recanalization of patients after endovascular therapy.","authors":"Bing-Hu Li, Li-Rong Wang, Jie Huang, Shu Yang, Bin Huang, Li-Jun Jia, Sen Zhou, Fu-Qiang Guo, Jian-Hong Wang, Neng-Wei Yu","doi":"10.2217/bmm-2023-0585","DOIUrl":"10.2217/bmm-2023-0585","url":null,"abstract":"<p><p><b>Aim:</b> To explore the association between the neutrophil-to-platelet ratio (NPR) and futile recanalization (FR) in patients with acute ischemic stroke due to large vascular occlusions after endovascular therapy (EVT). <b>Methods:</b> FR after EVT was defined as a poor 90-day prognosis (modified Rankin scale [mRS] score ≥3) despite successful reperfusion (modified thrombolysis in cerebral infarction grade 2b-3). Patients were divided into high NPR (>35; n = 115) and low NPR (≤35; n = 81) groups. <b>Results:</b> The FR rate was significantly higher in the high NPR group than low NPR group (81.74 vs 55.56%; p = 0.000). NPR was independently associated with FR (odds ratio: 2.107; 95% CI: 1.017-4.364; p = 0.045). <b>Conclusion:</b> High NPR was associated with the risk of FR in patients with acute ischemic stroke due to large vascular occlusions.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"137-143"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction. 脓毒症诱发心肌功能障碍时初始钠尿肽的 Meta 分析。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-02-01 Epub Date: 2024-02-21 DOI: 10.2217/bmm-2023-0605
Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao
{"title":"Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction.","authors":"Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao","doi":"10.2217/bmm-2023-0605","DOIUrl":"10.2217/bmm-2023-0605","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. <b>Methods:</b> Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. <b>Results:</b> Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0.81). <b>Conclusion:</b> Initial blood BNP and NT-proBNP levels are useful to assist in the detection of SIMD and further studies are warranted to determine the SIMD definition.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"145-155"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid accumulation product is a valid predictor of hepatic steatosis and nonalcoholic fatty liver disease. 脂质累积产物是预测肝脏脂肪变性和非酒精性脂肪肝的有效指标。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-02-01 Epub Date: 2024-03-08 DOI: 10.2217/bmm-2023-0725
Qiaoli Huang, Xuying Tan, Qiongmei Wu, Hanqing Zhao, Hangjun Chen, Xinxue Yu, Jinting Wang, Xueyi Huang, Yurong Huang, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
{"title":"Lipid accumulation product is a valid predictor of hepatic steatosis and nonalcoholic fatty liver disease.","authors":"Qiaoli Huang, Xuying Tan, Qiongmei Wu, Hanqing Zhao, Hangjun Chen, Xinxue Yu, Jinting Wang, Xueyi Huang, Yurong Huang, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang","doi":"10.2217/bmm-2023-0725","DOIUrl":"10.2217/bmm-2023-0725","url":null,"abstract":"<p><p><b>Aims:</b> To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate aminotransferase (AST), visceral adiposity index (VAI) and triglyceride-glucose index (TyG) as biomarkers for hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). <b>Methods:</b> LAP, ALT, AST, VAI and TyG were measured in 52 biopsy-proven NAFLD patients and 21 control subjects. Additionally, LAP was also measured in 448 ultrasound-proven NAFLD patients and 1009 control subjects. <b>Results:</b> LAP was positively associated with hepatic steatosis and inflammation in biopsy-proven NAFLD. The risk of NAFLD was positively related to LAP and TyG, but LAP showed a better area under the receiver operating characteristic curve for hepatic steatosis and NAFLD. LAP also performed well in recognizing ultrasound-proven NAFLD. <b>Conclusion:</b> LAP is an ideal biomarker of hepatic steatosis and NAFLD.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"123-135"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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