Biomarkers in medicine最新文献_第5页

Septin9 gene methylation in plasma for gastric cancer detection: a systematic review and meta-analysis. 血浆Septin9基因甲基化检测胃癌：系统综述和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-12 DOI: 10.1080/17520363.2026.2685066

Yiming Wang, Yuan Wang, Jiaqi Kang, Shan He, Ping Zhang

{"title":"Septin9 gene methylation in plasma for gastric cancer detection: a systematic review and meta-analysis.","authors":"Yiming Wang, Yuan Wang, Jiaqi Kang, Shan He, Ping Zhang","doi":"10.1080/17520363.2026.2685066","DOIUrl":"10.1080/17520363.2026.2685066","url":null,"abstract":"Objective: To evaluate the plasma-based methylated Septin9 (mSEPT9) diagnostic accuracy for gastric cancer (GC) and analyze its performance across different subgroups.Methods: Through comprehensive computer searching, we systematically collected clinical trials on the diagnostic efficacy of plasma mSEPT9 in GC. The search scope covered PubMed, Web of Science, the Cochrane Library, Embase, CNKI, WanFang Data and VIP databases from their establishments to 31 August 2025. Study quality was rigorously assessed with the assistance of Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Meta-analysis via Stata 17.0 and Meta-Disc 1.4 was performed.Results: This study included 9 articles containing 10 studies, encompassing 3,120 participants. Meta-analysis revealed a pooled sensitivity of 0.40 (95%CI: 0.34-0.47), specificity of 0.94 (95%CI: 0.91-0.96), diagnostic odds ratio of 11.10 (95%CI: 6.42-19.18), area under the curve of 0.78 (95%CI: 0.74-0.82). Meta-regression identified sample size and positive criteria algorithm as potential contributors to heterogeneity in sensitivity, although the associations were only of borderline statistical significance. Other covariables were not significantly associated with heterogeneity.Conclusion: Plasma mSEPT9 demonstrated high specificity and relatively low sensitivity in GC. The assay may be unsuitable for general population screening but showed promise as an adjunctive marker in high-risk patients. Heterogeneity and geographical concentration may influence the assessment of mSEPT9.Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD420251140125.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"531-542"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between serum neopterin levels and disease activity in patients with spondyloarthropathy. 脊柱关节病患者血清新蝶呤水平与疾病活动度的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-21 DOI: 10.1080/17520363.2026.2686306

Ayza Kılıç, Rezan Koçak Ulucaköy, Zakir Osmanov, İdil Melis Çobanoğlu, Cemalettin Aybay, Feride Nur Göğüş

{"title":"The relationship between serum neopterin levels and disease activity in patients with spondyloarthropathy.","authors":"Ayza Kılıç, Rezan Koçak Ulucaköy, Zakir Osmanov, İdil Melis Çobanoğlu, Cemalettin Aybay, Feride Nur Göğüş","doi":"10.1080/17520363.2026.2686306","DOIUrl":"10.1080/17520363.2026.2686306","url":null,"abstract":"Objective: Biomarkers that accurately reflect disease activity and inflammatory burden are needed, particularly in the early stages of spondyloarthropathy (SpA). This study aimed to evaluate the association between serum neopterin levels and disease activity indices in patients with SpA.Methods: This cross-sectional study included 84 participants based on a priori sample size estimation: 21 patients with axial SpA (axSpA), 21 with peripheral SpA (pSpA), 21 with active rheumatoid arthritis (RA) and 21 healthy controls (HC). Disease activity in SpA was assessed using the Axial Spondyloarthritis Disease Activity Score (ASDAS) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). A disease activity was assessed using the Disease Activity Score in 28 Joints (DAS28). Serum neopterin levels were measured by Enzyme-Linked Immunosorbent Assay.Results: Serum neopterin levels differed significantly among the groups (post-hoc, p = 0.007), with higher levels observed in patients with active RA than in those with axSpA, and no significant associations were found between neopterin levels and disease activity indices in either axial or peripheral SpA.Conclusion: In the present study cohort, no significant association was observed between serum neopterin levels and disease activity in patients with axial or peripheral SpA.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"511-518"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent prognostic performance of inflammatory biomarkers after AMI: results from the INFINITY study. AMI后炎症生物标志物的时间依赖性预后表现：INFINITY研究的结果。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-07-05 DOI: 10.1080/17520363.2026.2692043

A Mitsis, K Tsiaktani, S K Tasoulis, J Lakoumentas, G Karmioti, M Kyriakou, S Sokratous, M Drakomathioulakis, C Eftychiou, S Tzikas, N P E Kadoglou, G Kassimis

{"title":"Time-dependent prognostic performance of inflammatory biomarkers after AMI: results from the INFINITY study.","authors":"A Mitsis, K Tsiaktani, S K Tasoulis, J Lakoumentas, G Karmioti, M Kyriakou, S Sokratous, M Drakomathioulakis, C Eftychiou, S Tzikas, N P E Kadoglou, G Kassimis","doi":"10.1080/17520363.2026.2692043","DOIUrl":"10.1080/17520363.2026.2692043","url":null,"abstract":"Background: Inflammatory biomarkers derived from routine blood counts reflect immune activation in acute myocardial infarction (AMI). However, their temporal prognostic relevance after AMI remains uncertain.Methods: This prospective sub-study of the INFINITY trial (NCT06065514) included 100 consecutive patients with AMI. Five admission-derived inflammatory biomarkers were evaluated: systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR). Major adverse cardiovascular events (MACEs) were assessed cumulatively during hospitalization and at 1, 6, and 12 months. Associations were evaluated using non-parametric tests, receiver operating characteristic analysis, Kaplan-Meier survival curves, and parsimonious logistic regression adjusted for GRACE score.Results: No inflammatory biomarker predicted in-hospital events. At 1-month, elevated SIRI was associated with MACEs (p = 0.017; AUC 0.77), identifying early post-discharge vulnerability. At 6 months, SII (p = 0.036), NLR (p = 0.031), and SIRI (p = 0.032) were associated with adverse outcomes with moderate discrimination (AUC ≈0.69). Associations were attenuated after adjustment for the GRACE score. Nobiomarker demonstrated consistent prognostic value at 12 months.Conclusions: Admission-derived inflammatory biomarkers show a dynamic prognostic profile after AMI.SIRI identifies early risk, while broader inflammatory activation relates to mid-term outcomes, suggesting complementary value for biomarker-based risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"471-482"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic and clinicopathological role of fibrinogen-to-albumin ratio in biliary tract cancers: a meta-analysis. 胆道肿瘤中纤维蛋白原与白蛋白比值的预后和临床病理作用：一项荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-19 DOI: 10.1080/17520363.2026.2691461

Yanchen Nie, Zongxin Zhang, Zhenghai Wu

{"title":"Prognostic and clinicopathological role of fibrinogen-to-albumin ratio in biliary tract cancers: a meta-analysis.","authors":"Yanchen Nie, Zongxin Zhang, Zhenghai Wu","doi":"10.1080/17520363.2026.2691461","DOIUrl":"10.1080/17520363.2026.2691461","url":null,"abstract":"Aims: Fibrinogen-to-albumin ratio (FAR) is investigated for the prognostic value of biliary tract cancers (BTCs), but outcomes were heterogenous. Consequently, the current meta-analysis was carried out for analyzing its precise prognostic impact on BTCs.Materials and methods: We systemically searched Web of Science, PubMed, Cochrane Library, and Embase till 20 November 2025. The significance of FAR in forecasting BTC overall survival (OS) along with recurrence-free survival (RFS) was examined through determining aggregate hazard ratios (HRs) alongside 95% confidence intervals (CIs).Results: There were nine articles enrolling 2071 cases collected for the present meta-analysis. As shown by our combined findings, higher FAR showed obvious correlation with decreased OS (HR = 2.34, 95% CI = 1.80-3.05, p < 0.001) and inferior RFS (HR = 2.07, 95% CI = 1.37-3.12, p < 0.001) of BTCs. Furthermore, from our combined data, higher FAR exhibited obvious correlation with low differentiation (OR = 1.71, 95% CI = 1.38-2.12, p < 0.001), lymph node (LN) metastasis (OR = 1.36, 95% CI = 1.05-1.76, p = 0.018), and advanced T stage (OR = 2.64, 95% CI = 1.78-3.93, p < 0.001) of BTCs.Conclusion: This meta-analysis demonstrated that elevated FAR was significantly associated with poor OS and inferior RFS in patients with BTCs. Moreover, high FAR was also tightly linked to low differentiation, LN metastasis, and higher T stage of BTCs.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"543-552"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum soluble CD163 as a predictor of intensive care need and mortality in community-acquired pneumonia. 血清可溶性CD163作为社区获得性肺炎重症监护需求和死亡率的预测因子

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-05-20 DOI: 10.1080/17520363.2026.2677197

Buğra Kerget, Ferhan Kerget, Burcu Nur Gülbahar, Mustafa Buğra Coşkuner, Ayşenur Sağ, Ahmet Kara, Alperen Aksakal, Esra Laloğlu

{"title":"Serum soluble CD163 as a predictor of intensive care need and mortality in community-acquired pneumonia.","authors":"Buğra Kerget, Ferhan Kerget, Burcu Nur Gülbahar, Mustafa Buğra Coşkuner, Ayşenur Sağ, Ahmet Kara, Alperen Aksakal, Esra Laloğlu","doi":"10.1080/17520363.2026.2677197","DOIUrl":"10.1080/17520363.2026.2677197","url":null,"abstract":"Aims: To evaluate the role of serum soluble CD163 (sCD163) in predicting intensive care unit (ICU) admission and mortality in patients with community-acquired pneumonia (CAP).Materials and methods: This prospective study included 135 participants (60 non-ICU CAP, 45 ICU CAP, and 30 healthy controls). Clinical and laboratory data were collected at admission. Serum sCD163 levels were measured using ELISA. Receiver operating characteristic (ROC) analysis and multivariate logistic regression were performed.Results: Patients requiring ICU care had significantly higher PSI, CURB-65, NLR, and sCD163 levels (all p < 0.05). sCD163 demonstrated strong predictive performance for ICU admission (AUC = 0.951, 95% CI 0.904-0.998), with a cutoff value of 4.94 ng/mL (sensitivity 96%, specificity 66%). In multivariate analysis, age and sCD163 levels were independently associated with in-hospital mortality (p < 0.05).Conclusion: Serum sCD163 is associated with disease severity, ICU requirement, and mortality in CAP. It may provide complementary value to established clinical scores for early risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"425-432"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis. ABO血型与胃癌结局之间的关系：kaplan - meier衍生的患者数据荟萃分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-06-11 DOI: 10.1080/17520363.2026.2678430

Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Rommel Mario Rodriguez Burbano, Mario Hiroyuki Hirata

{"title":"Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis.","authors":"Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Rommel Mario Rodriguez Burbano, Mario Hiroyuki Hirata","doi":"10.1080/17520363.2026.2678430","DOIUrl":"10.1080/17520363.2026.2678430","url":null,"abstract":"Background: Gastric cancer (GC) remains the fifth most common and lethal cancer worldwide, often diagnosed at advanced stages, with limited treatment options and poor survival. Beyond established risk factors, the ABO blood group system has been suggested as a potential prognostic factor, but evidence remains inconclusive.Methods: Medline, Scopus, and Web of Science were searched to 27 July 2025, for studies including GC patients with reported overall survival (OS) stratified by blood types O, A, B, and AB. Kaplan-Meier curves from eligible studies were digitized to reconstruct individual patient data, which were pooled to estimate median OS and hazard ratios (HR) using Cox regression.Results: Seven studies comprising 8,726 GC patients were included (O: 3,693; A: 946; B: 605; AB: 315). Median OS was highest for type O (85.1 months, 95% CI 77.5-86.4) and AB (78.2 months, 95% CI 73.9-NA), and lowest for type A (20.0 months, 95% CI 17.9-21.9) and B (35.5 months, 95% CI 27.9-78.5). Compared with non-O, type O had a significantly better prognosis (HR 0.63; p < 0.0001). Type A (HR 1.85; p < 0.0001) and type B (HR 1.20; p = 0.0018) were associated with worse survival, while type AB showed a favorable prognosis compared to non-AB (HR 0.83; p = 0.039).Conclusion: ABO blood group is a significant prognostic factor in GC, with types A and B linked to poorer survival.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"461-470"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the diagnostic value of tumor markers in patients with suspected malignant pleural effusions. 评价肿瘤标志物对疑似恶性胸腔积液的诊断价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-05-13 DOI: 10.1080/17520363.2026.2672068

Yanxia Yu, Zhen Wang, Lili Xu, Yanbing Wu, Feng Wang, Zhaohui Tong

{"title":"Evaluating the diagnostic value of tumor markers in patients with suspected malignant pleural effusions.","authors":"Yanxia Yu, Zhen Wang, Lili Xu, Yanbing Wu, Feng Wang, Zhaohui Tong","doi":"10.1080/17520363.2026.2672068","DOIUrl":"10.1080/17520363.2026.2672068","url":null,"abstract":"Aim: The diagnostic significance of pleural effusion (PE) tumor markers in malignant pleural effusions (MPEs) was determined.Methods: A retrospective analysis of 65 cases were pathologically diagnosed with MPEs and 49 cases with tuberculous pleural effusions (TPEs) based on the results of medical thoracoscopic pleural biopsies. The concentrations of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), cancer antigen 125 (CA-125), specific enolase (NSE), and squamous cell carcinoma (SCC) antigen were compared between the two groups.Results: The concentrations of PE CEA and CA 19-9 in the MPE group were significantly higher than the TPE group (p < 0.001). The optimal thresholds for diagnosis of an MPE with a PE CEA and CA 19-9 were 5.80 ng/ml and 12.52 U/ml, respectively, and specificities of 100% and 93.88%, respectively.Conclusions: The PE CEA and CA 19-9 combination is not superior to CEA alone in diagnosing an MPE. CA-125, NSE, and SCC antigen have no diagnostic value for diagnosing an MPE.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"419-424"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipoprotein-associated phospholipase A2, fasting blood glucose, and granulocyte count for diagnosing coronary heart disease. 脂蛋白相关磷脂酶A2，空腹血糖和粒细胞计数诊断冠心病。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-05-24 DOI: 10.1080/17520363.2026.2677198

Zhanxiang Lin, Cheng Tan, Xing He, Xiaoyang Fei, Pengju Jiang, Zicai Liu

{"title":"Lipoprotein-associated phospholipase A2, fasting blood glucose, and granulocyte count for diagnosing coronary heart disease.","authors":"Zhanxiang Lin, Cheng Tan, Xing He, Xiaoyang Fei, Pengju Jiang, Zicai Liu","doi":"10.1080/17520363.2026.2677198","DOIUrl":"10.1080/17520363.2026.2677198","url":null,"abstract":"Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a promising inflammatory biomarker for coronary heart disease (CHD). This study aimed to evaluate the diagnostic value of Lp-PLA2, both alone and in combination with fasting blood glucose (FBG) and granulocyte count (GC), while exploring age- and sex-specific diagnostic thresholds.Methods: This retrospective case-control study enrolled 206 CHD patients and 89 non-CHD controls. Serum biomarkers were measured, multivariable logistic regression identified independent risk factors, and diagnostic performance was assessed using receiver operating characteristic (ROC) curves.Results: Sex, hypertension, diabetes, Lp-PLA2, FBG, and GC were identified as independent risk factors for CHD. ROC analysis revealed optimal cutoff values of 137 μg/L for Lp-PLA2 (AUC = 0.913), 6.8 mmol/L for FBG (AUC = 0.611), and 4.5 × 109 /L for GC (AUC = 0.687). The combined model achieved an AUC of 0.917, with sensitivity of 0.956 and specificity of 0.708 at a predicted probability threshold of 0.4.Conclusion: Elevated serum Lp-PLA2 and GC were independently associated with CHD, whereas FBG showed an inverse adjusted association that should be interpreted cautiously. Lp-PLA2 showed the highest diagnostic efficacy, while combined assessment improved sensitivity. The proposed age- and sex-specific cutoffs may provide preliminary subgroup-specific reference values that require external validation.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"433-444"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating biomarker profile and its diagnostic predictive utility in age-related macular degeneration. 循环生物标志物谱及其在年龄相关性黄斑变性中的诊断预测效用。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-06-03 DOI: 10.1080/17520363.2026.2677199

Priya Battu, Suresh Sharma, Ramandeep Singh, Akshay Anand

{"title":"Circulating biomarker profile and its diagnostic predictive utility in age-related macular degeneration.","authors":"Priya Battu, Suresh Sharma, Ramandeep Singh, Akshay Anand","doi":"10.1080/17520363.2026.2677199","DOIUrl":"10.1080/17520363.2026.2677199","url":null,"abstract":"Purpose: We evaluated the serum expression profiles of proteins encoded by AMD-related genes in age-related macular degeneration patients and controls.Methods: In our case-control study, we employed Enzyme-linked immunosorbent assay (ELISA) to analyze the expression of Collagen type X alpha 1 chain (COL10A1), Transforming growth factor-beta receptor type 1(TGFβR1) and Tumor Necrosis Factor Receptor Superfamily (TNFRSF10A) in serum. We have also statistically analyzed the correlations among the biomarkers and further assessed their diagnostic potential using the least absolute shrinkage and selection operator (LASSO) regression.Results: Out of three evaluated serum protein levels, two were found to be significantly associated with AMD. The expression of COL10A1 was significantly upregulated (p < 0.0001), and TNFRSF10A was significantly downregulated (p < 0.0001) in AMD patients compared to controls. The LASSO logistic regression revealed that serum expression of COL10A1 and TNFRSF10A proteins can reliably differentiate AMD cases from controls with predictive accuracy of 87.3%.Conclusion: Our findings indicate that serum levels of COL10A1 and TNFRSF10A are significantly altered in AMD patients compared to controls. LASSO regression analyses further revealed that these proteins together have a strong ability to differentiate between AMD cases and controls, suggesting their potential as reliable biomarkers for risk prediction of AMD.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"409-418"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early prognostic value of combined procalcitonin and interleukin-6 in sepsis: a retrospective cohort study. 联合降钙素原和白介素-6在脓毒症中的早期预后价值：一项回顾性队列研究。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-06-02 DOI: 10.1080/17520363.2026.2682836

Xuefang Xia, Qinglan Zhu, Fenglian Chen, Ailing Shen

{"title":"Early prognostic value of combined procalcitonin and interleukin-6 in sepsis: a retrospective cohort study.","authors":"Xuefang Xia, Qinglan Zhu, Fenglian Chen, Ailing Shen","doi":"10.1080/17520363.2026.2682836","DOIUrl":"10.1080/17520363.2026.2682836","url":null,"abstract":"Aims: To investigate the value of combined procalcitonin (PCT) and interleukin-6 (IL-6) assessment for early risk stratification in sepsis.Patients and methods: This retrospective cohort study enrolled 375 patients with sepsis stratified by the first Sequential Organ Failure Assessment (SOFA) score within 24 h of admission. Serum PCT and IL-6 levels were collected. Multivariable logistic regression, receiver operating characteristic analysis, internal validation, decision curve analysis, and dynamic biomarker analyses were performed.Results: PCT and IL-6 levels increased progressively across risk strata and correlated positively with SOFA score (both p < 0.001). PCT remained independently associated with septic shock, whereas C-reactive protein remained independently associated with 28-d mortality. Combined PCT and IL-6 assessment showed improved predictive performance compared with either biomarker alone. Dynamic analyses further demonstrated significant differences in ΔPCT and ΔIL-6 among risk groups during d 1-7 of anti-infective therapy.Conclusion: Early PCT and IL-6 levels were associated with sepsis severity and adverse outcomes. Combined biomarker assessment may provide adjunctive value for early sepsis risk stratification when interpreted together with established clinical indicators.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"397-408"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0