Biomarkers in medicine最新文献_第5页

A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index. 急性冠脉综合征全因死亡率的新指标：CALLY指数。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483159

Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay

{"title":"A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index.","authors":"Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay","doi":"10.1080/17520363.2025.2483159","DOIUrl":"10.1080/17520363.2025.2483159","url":null,"abstract":"Aims: This study aimed to identify the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting all-cause mortality in acute coronary syndrome (ACS) patients who have undergone primary percutaneous coronary intervention (pPCI) for revascularization.Materials and methods: 505 patients who presented with ACS and underwent pPCI were retrospectively included in this single center study. CALLY index and other five prognostic scores were calculated. The median follow-up was 40 months. All-cause mortality was defined as the primary endpoint.Results: The median age of the patients was 59 years, 23.4% were female. The CALLY index was categorized into low (<0.7) and high (≥0.7). Age (p = 0.038), concomitant atrial fibrillation (p = 0.023), previous CABG (p = 0.001), ACE-I/ARB/ARNI use (p = 0.015), diuretic use (p = 0.021), and a low-CALLY index (p < 0.001) were identified as independent predictors of all-cause mortality in multivariate cox regression analysis. When compared to other prognostic scores according to AUC in ROC analysis, the CALLY index demonstrated the best ability to predict all-cause mortality. Additionally, patients with a high-CALLY index exhibited significantly better survival outcomes compared to those with a low-CALLY index (log-rank:p < 0.001).Conclusions: CALLY index can be utilized as a novel prognostic score for predicting all-cause mortality in ACS patients who have undergone pPCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"287-294"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study. 作为急性肾损伤预后标志物的可溶性 Klotho 平均水平：90 天随访研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-22 DOI: 10.1080/17520363.2025.2481018

ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu

{"title":"Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study.","authors":"ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu","doi":"10.1080/17520363.2025.2481018","DOIUrl":"10.1080/17520363.2025.2481018","url":null,"abstract":"Background: Klotho is highly expressed in the kidney and confers pleiotropic kidney protective effects. This study aimed to assess the soluble average Klotho level and its relationship to renal function and outcomes in participants with acute kidney injury (AKI).Methods: We recruited 102 participants with AKI and 30 healthy controls (HCs). For patients with AKI, serum soluble (sKlotho) levels upon admission to and discharge from hospital were measured to assess the relationship between sKlotho level and kidney function. Individuals with AKI were followed up for 90 days to determine the association between their average sKlotho level and short-term AKI outcomes.Results: The baseline sKlotho level in individuals with AKI at admission was significantly lower than that in HCs. For individuals with AKI, the sKlotho level was significantly lower in stage 3 than in stage 1 or 2. The sKlotho level was restored along with renal function improvement at discharge. During follow-up, a lower average, but not baseline, sKlotho level, or average sKlotho/creatinine ration predicted more AKI clinical outcomes.Conclusion: The sKlotho level decreased significantly with kidney injury and represented severity. The average sKlotho level inversely correlated with detrimental kidney outcomes and may have potential diagnostic and predictive roles in AKI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"243-250"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients. HE4水平与非小细胞肺癌患者PET代谢参数的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17520363.2025.2471744

Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan

{"title":"Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients.","authors":"Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan","doi":"10.1080/17520363.2025.2471744","DOIUrl":"10.1080/17520363.2025.2471744","url":null,"abstract":"Aim: To investigate the relationship between serum human epididymis protein 4 (HE4) levels and metabolic parameters of positron emission tomography (PET) imaging in patients with lung cancer.Methods: Sixty non-small cell lung cancer (NSCLC) patients were included in this prospective study. Demographic information, smoking status, comorbid pathologies, preoperative HE4 levels, PET imaging metabolic parameters, disease stage and histopathology were recorded.Results: Significant positive correlations between serum HE4 levels and all the metabolic parameters were observed (p < 0.05). In univariate regression analyses, it was observed that high serum HE4 levels could indicate tumor be squamous cell carcinoma (SCC) (p = 0.029), advanced T stage (p = 0.041), and have high maximum standart uptake value (SUVmax) (p = 0.017).Conclusion: Serum HE4 levels can be used as a biomarker to predict tumor burden and metabolic activity for NSCLC patients. Although sufficient per power analysis, this study may have benefited from further expansion, and by patient heterogeneity in TNM stage and tumor histology, potentially affecting the assessment of parameter relationships.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"259-265"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk. 冠状动脉扩张预测：Intermountain风险评分在识别危险患者中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483158

Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan

{"title":"Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk.","authors":"Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan","doi":"10.1080/17520363.2025.2483158","DOIUrl":"10.1080/17520363.2025.2483158","url":null,"abstract":"Aims: This study evaluates the association between the Intermountain Risk Score (IMRS) and coronary artery ectasia (CAE) to determine its predictive value.Materials & methods: A retrospective study was conducted at a tertiary hospital from January 2019 to January 2024. A total of 446 patients (226 with CAE, 220 controls) were included. Clinical, laboratory, and angiographic data were analyzed. IMRS was calculated based on routine demographic and laboratory parameters. Statistical analyses included logistic regression and receiver operating characteristic (ROC) curve analysis.Results: Patients with CAE had significantly higher IMRS scores (p = 0.011) and were more likely to fall into high-risk IMRS categories (p = 0.002). Smoking (HR: 3.744, p = 0.045), mean corpuscular volume (HR: 1.105, p = 0.019), and IMRS color category (HR: 5.255, p = 0.016) were independent predictors. ROC analysis showed an AUC of 0.617 for IMRS score and 0.627 for IMRS color category.Conclusions: IMRS is a significant predictor of CAE and may serve as a practical risk stratification tool. Higher-risk patients could benefit from closer monitoring and targeted interventions. Further validation in prospective studies is needed.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"295-304"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome. TyG指数在预测急性冠状动脉综合征后左室低射血分数中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1080/17520363.2025.2485017

Ozlem Ozbek, Erdal Belen

{"title":"The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.","authors":"Ozlem Ozbek, Erdal Belen","doi":"10.1080/17520363.2025.2485017","DOIUrl":"10.1080/17520363.2025.2485017","url":null,"abstract":"Aims: This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.Methods & results: This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (p = 0.004), diabetes mellitus (p = 0.017), previous coronary artery disease (CAD) (p < 0.001), ST-elevation myocardial infarction (STEMI) (p < 0.001) and high (≥4.95) TyG index (p < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (p = 0.031), previous CAD (p = 0.001), peripheral artery disease (p = 0.038), renal diseases (p = 0.011), STEMI (p < 0.001) and high (≥5.10) TyG index (p < 0.001).Conclusions: The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"267-275"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KLK8: charting new territories in left ventricular hypertrophy biomarker research. KLK8：左心室肥厚生物标志物研究的新领域。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1080/17520363.2025.2483153

Buqing Cao, Wenhong Yu, Zhihong Diao, Zhenli Ma, Shineng Yan, Lihua Yang, Xiaoqun Huang, Jingmei Yang

{"title":"KLK8: charting new territories in left ventricular hypertrophy biomarker research.","authors":"Buqing Cao, Wenhong Yu, Zhihong Diao, Zhenli Ma, Shineng Yan, Lihua Yang, Xiaoqun Huang, Jingmei Yang","doi":"10.1080/17520363.2025.2483153","DOIUrl":"10.1080/17520363.2025.2483153","url":null,"abstract":"Objective: This study investigates the diagnostic potential of serum Kallikrein-related peptidase 8 (KLK8) in detecting left ventricular hypertrophy (LVH).Methods: A total of 62 hypertensive patients with LVH, 60 without LVH, and 60 healthy controls were analyzed. LVH was defined by echocardiography using LVMI thresholds (>95 g/m2 for females, >115 g/m2 for males). Serum KLK8 levels were measured via ELISA, and receiver operating characteristic (ROC) curve analysis assessed its diagnostic performance.Results: KLK8 levels were significantly higher in hypertensive patients with LVH (8.59 ± 1.59 ng/mL) than in those without LVH (5.80 ± 1.35 ng/mL) and healthy controls (3.68 ± 0.82 ng/mL). KLK8 positively correlated with blood pressure and cardiac structural parameters, including IVST, LVPWT, and LVEDD. ROC analysis revealed high sensitivity and specificity, indicating KLK8's potential as a biomarker for early LVH detection in hypertension.Conclusion: In hypertensive patients, KLK8 demonstrates good diagnostic value in predicting LVH.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"277-286"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive biomarker profiles in hematological malignancies: improving diagnosis, prognosis, and treatment. 血液恶性肿瘤的综合生物标志物图谱：改善诊断、预后和治疗。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-27 DOI: 10.1080/17520363.2025.2471745

Ali Golestan, Mohammadrasul Zareinejad, Amin Ramezani

{"title":"Comprehensive biomarker profiles in hematological malignancies: improving diagnosis, prognosis, and treatment.","authors":"Ali Golestan, Mohammadrasul Zareinejad, Amin Ramezani","doi":"10.1080/17520363.2025.2471745","DOIUrl":"10.1080/17520363.2025.2471745","url":null,"abstract":"Hematological malignancies present substantial challenges in clinical practice due to their heterogeneity and complex biological profiles. In these diseases, biomarkers - measurable indicators of biological states - are indispensable for diagnosis, prognosis, and therapeutic decision-making. Emerging biomarkers are significantly improving outcomes in hematological cancers by enhancing early detection, refining prognostic assessments, enabling personalized treatment approaches, and optimizing overall patient management. This progress translates into better clinical outcomes and more effective strategies to treat and manage malignancies. The field of biomarker discovery has developed from basic morphological and cytogenetic markers to advanced molecular techniques, including polymerase chain reaction (PCR) and next-generation sequencing (NGS), which have significantly enhanced diagnostic accuracy and led to the development of targeted therapies. Additionally, the recent advent of technologies like mass spectrometry and single-cell RNA sequencing enables comprehensive molecular profiling and reveals novel biomarkers that were previously undetectable. Our aim in this manuscript is to provide a comprehensive overview of recent and novel immunohematological biomarkers, their diagnostic and therapeutic applications, and the future directions of this field.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"223-238"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel inflammatory biomarkers for discriminating vascular involvement in Behçet's syndrome: evaluating SII, SIRI, and NPAR. 鉴别behet综合征血管受累的新型炎症生物标志物：评估SII、SIRI和NPAR。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-03-02 DOI: 10.1080/17520363.2025.2473312

Bahar Özdemir Ulusoy, Berkan Armağan, Esra Kayacan Erdoğan, Yüksel Maraş, İsmail Doğan, Kevser Orhan, Serdar Can Güven, Ebru Atalar, Hatice Ecem Konak, Pınar Akyüz Dağlı, Ahmet Omma, Orhan Küçükşahin, Şükran Erten, Hakan Babaoğlu

{"title":"Novel inflammatory biomarkers for discriminating vascular involvement in Behçet's syndrome: evaluating SII, SIRI, and NPAR.","authors":"Bahar Özdemir Ulusoy, Berkan Armağan, Esra Kayacan Erdoğan, Yüksel Maraş, İsmail Doğan, Kevser Orhan, Serdar Can Güven, Ebru Atalar, Hatice Ecem Konak, Pınar Akyüz Dağlı, Ahmet Omma, Orhan Küçükşahin, Şükran Erten, Hakan Babaoğlu","doi":"10.1080/17520363.2025.2473312","DOIUrl":"10.1080/17520363.2025.2473312","url":null,"abstract":"Objective: This study aims to investigate discriminatory ability of the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Neutrophil Percentage-to-Albumin Ratio (NPAR), in differentiating Behçet's Syndrome (BS) organ involvements from mucocutaneous involvement.Methods: This retrospective cohort study analyzed 436 patients diagnosed with BS from 2018 to 2023. Patients were categorized into three groups based on organ involvement: vascular, only mucocutaneous, and other organ involvement. Receiver Operating Characteristic (ROC) analysis was used to evaluate the discriminatory ability (mucocutaneous vs rest, vascular vs rest). DeLong's test was used to determine statistical differences in discriminatory power between the models.Results: Out of 436, 115 patients had vascular involvement. SII, SIRI, and NPAR were notably elevated in the vascular involvement group (p < 0.001). ROC analysis revealed that, SII, SIRI and NPAR showed discriminative ability for vascular involvement with AUCs of 0.87 for SII, 0.87 for SIRI, and 0.88 for NPAR. Pairwise comparisons using DeLong's test indicated that all three models performed similarly.Conclusion: SII, SIRI, and NPAR are promising noninvasive biomarkers for predicting vascular involvement. These indices, derived from routine laboratory tests, could enhance early screening and may improve patient outcomes by enabling timely intervention.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"149-156"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic role of circulating cell-free DNA in schizophrenia and neuro-degenerative disorders. 循环无细胞DNA在精神分裂症和神经退行性疾病中的诊断作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-24 DOI: 10.1080/17520363.2025.2468151

Miltiadis Perdikakis, Dimosthenis Papadimitrakis, Nikitas Floros, Elias Tzavellas, Christina Piperi, Antonios N Gargalionis, Athanasios G Papavassiliou

{"title":"Diagnostic role of circulating cell-free DNA in schizophrenia and neuro-degenerative disorders.","authors":"Miltiadis Perdikakis, Dimosthenis Papadimitrakis, Nikitas Floros, Elias Tzavellas, Christina Piperi, Antonios N Gargalionis, Athanasios G Papavassiliou","doi":"10.1080/17520363.2025.2468151","DOIUrl":"10.1080/17520363.2025.2468151","url":null,"abstract":"Over the past few years, circulating cell-free DNA (cfDNA) research has grown exponentially. Several studies have associated the release of cfDNA in the bloodstream, cerebrospinal fluid, and other body fluids with increased apoptosis and cell death. Therefore, their possible use as biomarkers for cancer and other diseases has emerged. The diagnosis of pathological entities such as schizophrenia and neurodegenerative diseases involves many challenges and requires ruling out conditions with similar symptoms. In this context, cfDNA could serve as a valuable diagnostic biomarker. This study encompasses the recent bibliography and research regarding the utilization of circulating cfDNA for diagnostic purposes in schizophrenia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. This minimally invasive method has provided important evidence regarding the diagnosis of the aforementioned diseases although further research is necessary.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"165-176"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of HALP score in predicting in-hospital mortality in patients with NSTEMI. HALP评分预测非stemi患者住院死亡率的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1080/17520363.2025.2468144

Dogan Ilis, Ayca Arslan, Inanc Artac, Muammer Karakayali, Timor Omar, Serif Hamideyin, Hatice Taşkan, Ozcan Yagicibulut, Yavuz Karabag, Ibrahim Rencuzogullari

{"title":"Prognostic value of HALP score in predicting in-hospital mortality in patients with NSTEMI.","authors":"Dogan Ilis, Ayca Arslan, Inanc Artac, Muammer Karakayali, Timor Omar, Serif Hamideyin, Hatice Taşkan, Ozcan Yagicibulut, Yavuz Karabag, Ibrahim Rencuzogullari","doi":"10.1080/17520363.2025.2468144","DOIUrl":"10.1080/17520363.2025.2468144","url":null,"abstract":"Aims: We aimed to investigate the association between the HALP score and in-hospital mortality in patients with non-ST segment myocardial infarction (NSTEMI).Materials and methods: In this retrospective study participants were divided into two groups, based on the median HALP score. Findings were compared between the groups.Results: A total of 1648 patients included. The median HALP score cutoff value was 3.87. While the low HALP score group (<3.87) included 824 patients, the high HALP score group (>3.87) included 824 patients. Patients with the low HALP score were older and had a higher prevalence of comorbidities. A HALP score ≤ 2.62 predicted in-hospital mortality with sensitivity of 72.5% and a specificity of 77.3% (area under curve 0.809), according to ROC curve analysis. In multivariate analysis, age, diastolic blood pressure, Killip Class > 1 and Syntax Score, creatinine level, LVEF and HALP Score (OR: 0.504, 95% CI: 0.415-0.613; p < 0.001) were independently associated with in-hospital mortality.Conclusions: According to the current study, the HALP score was independently associated with in-hospital mortality in patients with NSTEMI. Moreover, HALP score might be used as a predictor of in-hospital mortality in this population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"139-147"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0