Biomarkers in medicine最新文献_第5页

Association between serum corin levels and functional capacity in patients with advanced heart failure. 晚期心力衰竭患者血清科林水平与功能能力的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/17520363.2025.2511473

Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar

{"title":"Association between serum corin levels and functional capacity in patients with advanced heart failure.","authors":"Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar","doi":"10.1080/17520363.2025.2511473","DOIUrl":"10.1080/17520363.2025.2511473","url":null,"abstract":"Background: Corin is a cardiac protease that plays a role in transforming pro-natriuretic peptides into their active biological forms. This study aimed to investigate the relationship between serum corin levels and functional capacity in patients with advanced heart failure.Methods: This cross-sectional study included 88 consecutive patients with LVEF (Left ventricular ejection fraction) <25% who were referred to the tertiary cardiovascular center. Serum corin levels were measured using ELISA (Enzyme-linked immunosorbent assay) prior to CPET (Cardiopulmonary exercise testing). Multivariable linear regression was used to assess the independent association between serum corin levels and peak VO₂ (Peak oxygen consumption).Results: The mean age was 51.3 ± 12.2 years, and 86.4% were male. The mean peak VO₂ was 13.6 ± 3.99 mL/min/kg and the mean serum corin level was 1.7 ± 0.82 ng/mL. In multivariable analysis, serum corin level was an independent predictor of peak VO₂ (Coefficient: 1.206, 95% CI: 0.527-1.880, p = 0.0007).Conclusion: Lower serum corin levels are independently associated with reduced functional capacity in advanced heart failure. Corin may serve as a valuable biomarker to complement CPET in clinical evaluation, risk stratification, and treatment planning.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"395-403"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis. 种族改变了microRNA单核苷酸多态性与儿童急性淋巴细胞白血病风险之间的关系：一项荟萃分析。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI: 10.1080/17520363.2025.2511466

Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy

{"title":"Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis.","authors":"Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy","doi":"10.1080/17520363.2025.2511466","DOIUrl":"10.1080/17520363.2025.2511466","url":null,"abstract":"Introduction: MicroRNA (miRNA) single nucleotide polymorphisms (miRNA-SNPs) have been associated with pediatric acute lymphoblastic leukemia (ALL). However, since the results of these individual studies have been inconsistent, we performed a meta-analysis to help establish a statistical significance for the association between miRNA-SNPs and pediatric ALL risk. We also analyzed whether they confer susceptibility across country-specific studies by using different genetic models.Methods: Articles published from 2001 to 2023 were collected from PubMed and Google Scholar databases. Through MetaGenyo, the association between miRNA- SNPs and pediatric ALL risk was calculated by pooled odds ratio [ORs] and 95% CI. A subgroup analysis of pooled ORs in country-specific studies was also performed.Results: Based on the inclusion and exclusion criteria, 14 studies were analyzed to extract data on miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915 and mir-499 rs3746444. While the pooled data analysis did not reveal any association, a subgroup analysis demonstrated country-specific differences in allele frequencies of all the four miRNAs in various genetic models, implying ethnicity-based risk.Conclusion: Our results suggested that miRNA-SNPS can still be considered as a potential risk factor to be explored in more populations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"435-449"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia. 妊娠早期中性粒细胞百分比-白蛋白比率：一种新的子痫前期预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI: 10.1080/17520363.2025.2511468

Çağlayan Biçer, Fatih Akkuş, Yusuf Dal

{"title":"First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia.","authors":"Çağlayan Biçer, Fatih Akkuş, Yusuf Dal","doi":"10.1080/17520363.2025.2511468","DOIUrl":"10.1080/17520363.2025.2511468","url":null,"abstract":"Objective: This retrospective study evaluated the predictive power of a new marker for pre-eclampsia (PE), the neutrophil percentage/albumin ratio (NPAR).Methods: A total of 399 participants consisting of 133 pregnant women diagnosed with PE and 266 healthy pregnant controls were included in the study. Data collected included demographic and obstetric history, gestational age at diagnosis, maternal hematological and biochemical parameters, first trimester neutrophil/albumin ratio (NAR) and NPAR values, and neonatal outcomes.Results: The pre-eclampsia group showed significantly higher NAR (mean: 312.30, range: 80.00-1568.00) and NPAR (mean: 3.14 ± 0.81) compared to the control group (mean NAR: 234.40, range: 78.16-725.00; mean NPAR: 2.06 ± 0.38; p = 0.001 for both). Furthermore, early-onset PE was associated with significantly higher NAR (395.00 vs. 256.23, p = 0.001) and NPAR (3.87 vs. 2.80, p = 0.001) compared to late-onset PE. For early-onset PE, NPAR showed a sensitivity of 76.19%, specificity of 92.31%, PPV of 82.05%, NPV of 89.36% and area under the curve (AUC) of 0.897, demonstrating its strong potential as an early predictor of pre-eclampsia.Conclusion: NPAR is elevated in PE compared to healthy pregnancies, demonstrating its potential as a simple yet effective biomarker for predicting PE.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"415-423"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation. 经导管主动脉瓣植入术后血清乳酸水平与住院死亡率的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI: 10.1080/17520363.2025.2517524

Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi

{"title":"The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation.","authors":"Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi","doi":"10.1080/17520363.2025.2517524","DOIUrl":"10.1080/17520363.2025.2517524","url":null,"abstract":"Background: This study assesses the influence of early hyperlactatemia after the transcatheter aortic valve implantation (TAVI) procedure on subsequent outcomes.Methods: Adult patients undergoing elective percutaneous TAVI between 2012 and 2022 in a single tertiary cardiac center were retrospectively included. Peak post-procedure lactate level within 24-h was recorded for 284 patients included in the study. The primary outcome measured was 30-day mortality.Results: 19 patients (6.6%) experienced 30-day mortality. Patients with mortality were characterized by advanced age (p = 0.022) and higher lactate levels after the procedure (5.4 ± 5.4 mmol/L vs 1.3 ± 0.6 mmol/L, p < 0.001). Post-procedure hyperlactatemia was an independent predictor of mortality (OR 3.95, 95% CI 1.35-11.60, p = 0.012). ROC analysis revealed 1.54 mmol/L as a cutoff for mortality with 85.7% specificity and 68.4% sensitivity.Conclusion: The initial 24-hour lactate levels seem to play a valuable role in predicting the likelihood of surviving during the hospital stay after the implantation procedure. Further investigation is required to ascertain the optimal strategies for managing early post-procedure hyperlactatemia in the TAVI population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"481-489"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter. 2型心肾综合征的预测因子和预后模型：一项多中心回顾性研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1080/17520363.2025.2520738

Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan

{"title":"Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter.","authors":"Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan","doi":"10.1080/17520363.2025.2520738","DOIUrl":"10.1080/17520363.2025.2520738","url":null,"abstract":"Background: Type 2 CRS is characterized by the development of renal dysfunction secondary to chronic cardiac disease. Despite its high morbidity and mortality, there is a lack of robust diagnostic tools and prognostic models to guide clinical management.Methods: This multicenter retrospective study included patients diagnosed with CRS type 2 based on the 2019 American Heart Association definition. Data were collected from electronic medical records of three hospitals between January 2021 and December 2023. Advanced statistical methods, including receiver operating characteristic (ROC) curve analysis, univariate Kaplan-Meier (KM) analysis, and multivariable Cox proportional hazards regression, were utilized to develop a nomogram for predicting patient prognosis.Results: The study included 519 patients with CRS-2. Independent predictors of adverse outcomes included elevated serum creatinine and blood urea nitrogen (BUN) levels, decreased platelet count, elevated B-type natriuretic peptide (BNP), and decreased oxygen partial pressure (PaO2). These findings suggest that close monitoring of these markers is essential in clinical practice to identify patients at high risk of adverse events early on.Conclusion: Our study provides evidence that serum creatinine, BUN, platelet count, BNP, and PaO2 are independent predictors of adverse outcomes in patients with Type 2 CRS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"491-499"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor on the article "Clinical relevance of HRR and RAR in pericarditis" by Hatice Eyiol et al. 关于Hatice Eyiol等人的文章“心包炎HRR和RAR的临床相关性”致编辑的信。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1080/17520363.2025.2508136

Francesca Casarin, Ruggiero Mascolo, Antonio Brucato

引用次数: 0

Expanding risk stratification in acute coronary syndromes with systemic indices: HALP and CALLY. 扩大危险分层急性冠状动脉综合征与系统指标：HALP和CALLY。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-08 DOI: 10.1080/17520363.2025.2517525

Ashok Kumar Pannu

引用次数: 0

Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model. RCS模型检测血清GP73、Nrf2、CHE对妊娠早期肝损伤的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-07 DOI: 10.1080/17520363.2025.2516998

Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia, Xiaoqing Li, Congcong Sun, Hongping Zhang, Jiayong Zheng

{"title":"Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model.","authors":"Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia, Xiaoqing Li, Congcong Sun, Hongping Zhang, Jiayong Zheng","doi":"10.1080/17520363.2025.2516998","DOIUrl":"10.1080/17520363.2025.2516998","url":null,"abstract":"Background: This study assessed serum GP73, Nrf2, and CHE levels in pregnancy-associated liver injury and explored their nonlinear risk relationships using restricted cubic spline (RCS) models to establish diagnostic thresholds for early screening.Methods: Conducted from December 2022 to December 2024, 105 pregnant women with liver injury (research group) and 187 healthy controls were retrospectively analyzed. Multivariate logistic regression, ROC curves, RCS models, and decision curve analysis (DCA) evaluated associations, predictive efficacy, dose-response relationships, and clinical utility of these biomarkers.Results: Elevated GP73 and Nrf2, multiple pregnancies, antipyretic/anti-infective medication use, and malnutrition were risk factors (p < 0.05), while high CHE was protective (p < 0.05). ROC analysis showed AUCs of 0.801 (GP73), 0.785 (Nrf2), and 0.726 (CHE) combined AUC reached 0.951. RCS revealed nonlinear dose-response relationships (p < 0.001), and DCA confirmed clinical significance (net benefit > 0) for individual and combined biomarkers, with the panel showing the highest utility.Conclusion: GP73, Nrf2, and CHE demonstrated nonlinear associations with pregnancy-related liver injury, particularly GP73. Combined measurement enhances clinical value for early prediction.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"455-462"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis. 老年急性结石性胆囊炎患者入院时血糖异常及预后。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17520363.2025.2501925

Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu

{"title":"Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis.","authors":"Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu","doi":"10.1080/17520363.2025.2501925","DOIUrl":"10.1080/17520363.2025.2501925","url":null,"abstract":"Introduction: We investigated the potential correlation between abnormal blood glucose on admission and clinical outcomes of acute calculus cholecystitis in older patients.Areas covered: We included older patients (≥65 years) diagnosed with acute calculus cholecystitis. The first plasma glucose measurement obtained at admission was used. Overall, 280 older patients were evaluated. The results showed that ABG was significantly associated with more severe systemic inflammatory responses (elevated white blood cell count and neutrophil-lymphocyte ratio), a higher incidence of moderate to severe ACC, and the need for invasive treatment (an increased proportion of percutaneous cholecystostomy and combined surgeries). The prolonged hospital stay, 30-day readmission rate and mortality rate of patients in the ABG group were significantly increased, and the incidence of severe postoperative complications (Clavien-Dindo≥grade III) was higher. Multivariate analysis confirmed that ABG was an independent predictor of the severity of ACC (TG18 classification) and 30-day re-admission rate.Expert opinion/commentary: In older patients with acute calculus cholecystitis, abnormal blood glucose on admission is associated with worse outcomes, serving as a novel quantifiable risk criterion to guide treatment selection, particularly for high-risk older adults ineligible for early surgery.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"405-414"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC. RUNX1启动子rs2071029多态性对辅助化疗诱导的结直肠癌中性粒细胞减少的易感性

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1080/17520363.2025.2516996

Xikai Luo, Hao Wang, Zhe Huang, Zhuocheng Lin, Chunpeng Li, Qiwen Wang, Yisheng Wei

{"title":"Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC.","authors":"Xikai Luo, Hao Wang, Zhe Huang, Zhuocheng Lin, Chunpeng Li, Qiwen Wang, Yisheng Wei","doi":"10.1080/17520363.2025.2516996","DOIUrl":"10.1080/17520363.2025.2516996","url":null,"abstract":"Aim: To investigate the susceptibility of Runt-related transcription factor 1 (RUNX1) promoter polymorphism to adjuvant chemotherapy-induced neutropenia (CIN) of colorectal cancer (CRC).Methods: RUNX1 promoter polymorphisms rs2071029 and rs12626613 were genotyped by SnaPshot genotyping and Sanger sequencing. The association of rs2071029 and CIN in 204 CRC patients was analyzed using chi-square test and multivariate logistic regression model. The impact of rs2071029 polymorphism on RUNX1 promoter activity was analyzed by luciferase assay.Results: Rs2071029 and rs12626613 loci were in strong linkage disequilibrium (D ' = 0.957. r2 = 0.878). Compared with rs2071029 CC genotype, TT (OR = 0.250, 95% CI: 0.101∼0.617) had a decreased risk of severe CIN. Compared with mFOLFOX6,and baseline neutrophil counts 2-4 × 109/L, Xelox (OR = 0.169, 95% CI: 0.054∼0.531) and >4 × 109/L(OR = 0.446 95% CI: 0.209∼0.952) had a decreased risk of severe CIN, respectively. Rs2071029T promoter activity was significantly higher than that of rs2071029C promoter (p = 0.014). Stratified analyses revealed that the protective effect of the rs2071029 TT was more pronounced in patients over 60 years (OR = 0.139, 95% CI: 0.031-0.622) and stage II cases (OR = 0.117, 95% CI: 0.018-0.745).Conclusion: RUNX1 promoter rs2071029 polymorphism could be useful as an independent biomarker for CIN in CRC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"471-479"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0