Biomarkers in medicine最新文献_第5页

The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis. c反应蛋白-白蛋白比值预测溃疡性结肠炎疾病活动性的能力。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1080/17520363.2025.2459596

Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin

{"title":"The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis.","authors":"Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin","doi":"10.1080/17520363.2025.2459596","DOIUrl":"10.1080/17520363.2025.2459596","url":null,"abstract":"Aim: Ulcerative colitis (UC) is an incurable disease represented by relapse and remission. Noninvasive biomarkers are required to predict disease activation. This study aimed to identify noninvasive biomarkers, such as the c-reactive protein-albumin (CRP/ALB) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), that might forecast disease activation in UC.Methods: This retrospective study included 443 participants: 192 patients with active UC, 166 in remission, and 85 healthy controls. Mayo Endoscopic Subscore was employed to assess endoscopic disease activity. Serum CRP, erythrocyte sedimentation rate (ESR), ALB levels, and complete blood count characteristics were documented. Three ratios of inflammation-related indicators were identified as CRP/ALB, PLR, and NLR.Results: A positive correlation was found between ESR, CRP, neutrophil count, platelet count, levels of CRP/ALB, PLR, NLR, and endoscopic activity. The CRP/ALB ratio demonstrated more efficacy than the NLR and PLR in differentiating the UC patients from the controls (p = 0.007, p = 0.003, respectively) and the active group from the remission group (p < 0.001, p < 0.001, respectively). Regression analysis revealed that the CRP/ALB was significantly able to distinguish active UC from the remission group and the controls (p < 0.001, p < 0.001, respectively).Conclusion: The CRP/ALB ratio could be useful as an independent predictive biomarker for disease activity in UC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"113-119"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI. 单核细胞与高密度脂蛋白胆固醇比值预测急性STEMI患者新发房颤。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1080/17520363.2025.2459590

Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek

{"title":"The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI.","authors":"Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek","doi":"10.1080/17520363.2025.2459590","DOIUrl":"10.1080/17520363.2025.2459590","url":null,"abstract":"Objective: Newly diagnosed AF (NOAF) associated with acute STEMI holds significant relevance in clinical practice. This study seeks to assess the role of the monocyte to HDL-C ratio (MHR) in predicting NOAF in these patients.Methods: Between July 2017 and May 2018, 663 patients who underwent primary PCI for STEMI were retrospectively analyzed. NOAF was identified in 34 patients (5.1%), and this group was compared with those without AF.Results: The NOAF group experienced a longer hospitalization duration and a higher mortality rate (11.8 vs. 4.3%, p = 0.044) compared to the non-AF group. In a multivariable analysis, increased MHR (OR: 1.413, 95% CI: 1.203-1.657, p = 0.005), advanced age, decreased LVEF, Killip class 2-4, diabetes mellitus, hypertension, and left atrial enlargement emerged as independent predictors for the development of NOAF in STEMI. ROC curve analysis revealed that MHR values exceeding 26.54 strongly predict NOAF, achieving sensitivity and specificity above 70% (AUC: 0.768, 95%CI: 0.734-0.801, p < 0.001).Conclusion: The present study revealed that increased MHR robust indicator for NOAF in STEMI patients and can be easily assessed in clinical practice. Incorporating MHR alongside established traditional risk factors may enhance the identification of patients at risk for AF in those with STEMI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"121-128"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence. HOTAIR表达作为多形性胶质母细胞瘤的生物标志物：对现有证据的综合荟萃分析

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1080/17520363.2025.2455925

Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi

{"title":"HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.","authors":"Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi","doi":"10.1080/17520363.2025.2455925","DOIUrl":"10.1080/17520363.2025.2455925","url":null,"abstract":"Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.Methods: We searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses.Results: The meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8-10.8, p = 0.00). Considerable heterogeneity was observed (Q-value: 1174.2, df = 9, I2 = 99.2%, p = 0.00). Subgroup analyses indicated significant associations in tissue samples and studies from the USA and China. Meta-regression revealed that study design and country contributed to the observed heterogeneity, with no significant publication bias detected.Conclusion: This analysis confirms the significant link between HOTAIR expression and GBM, highlighting HOTAIR as a potential therapeutic target and biomarker. Further research is necessary to clarify the biological mechanisms involved in this association.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"129-137"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum vitamin B12 concentrations in a patient with pancreatic exocrine insufficiency. 胰腺外分泌功能不全患者血清维生素B12浓度升高。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI: 10.1080/17520363.2025.2455927

Richard Makins, Emma Stevenson, Agata Sobczyńska-Malefora

引用次数: 0

Complement 3 and 4 impact in osteoarthritis. 补体3和4对骨关节炎的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-02-02 DOI: 10.1080/17520363.2024.2409062

Lifang Wang

引用次数: 0

Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy. 外泌体PD-L1在癌症治疗中的临床病理和预后意义。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/17520363.2024.2448117

Shunqin Hu, Fengchang Huang, Xiuying Li

{"title":"Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy.","authors":"Shunqin Hu, Fengchang Huang, Xiuying Li","doi":"10.1080/17520363.2024.2448117","DOIUrl":"10.1080/17520363.2024.2448117","url":null,"abstract":"Aim: The exosomal programmed death ligand-1(exoPD-L1) has recently become a topic of interest in the field of oncology. But the prognostic role of exoPD-L1 in cancer patients is inconsistent across previous studies. Therefore, a quantitative meta-analysis was performed to evaluate the prognostic and clinicopathological value of exoPD-L1 in cancer patients.Materials and methods: Twenty eligible studies were included in this study. The relationship between baseline level of exoPD-L1 and clinicopathological features, therapeutic response, overall survival (OS) and progression-free survival (PFS) was evaluated.Results: Pooled analysis indicated that high level of exoPD-L1 was significantly associated with higher tumor stage, positive lymph node metastasis, and advanced TNM stage. Elevated exoPD-L1 was associated with short OS [HR = 1.80 (1.27-2.55), p = 0.001]. In the subgroup analysis, high-level exoPD-L1 was consistently associated with poor OS in sample source, detection method, and lymphoma patients. Moreover, elevated exoPD-L1 was predictive of worse PFS [HR = 1.28 (1.13-4.18), p = 0.000]. In addition, a striking difference between cancer patients and healthy donors was observed in the level of exoPD-L1.Conclusion: exoPD-L1 is an original and effective liquid biomarker for cancer patients. However, large-scale, prospective investigations are still needed to confirm our findings.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 2","pages":"51-57"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi. 中性粒细胞与淋巴细胞比值和MELD评分对HBV-DeCi患者短期生存的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.1080/17520363.2024.2448112

Zhong Han, Liangshuai Qi, Sirui Chen, Jinfei Zhang, Xueliang Guo, Chunying Liang, Weiwei Zheng

{"title":"Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi.","authors":"Zhong Han, Liangshuai Qi, Sirui Chen, Jinfei Zhang, Xueliang Guo, Chunying Liang, Weiwei Zheng","doi":"10.1080/17520363.2024.2448112","DOIUrl":"10.1080/17520363.2024.2448112","url":null,"abstract":"Objective: The prognostic value of neutrophil-to-lymphocyte ratio (NLR) combined with Model for End-Stage Liver Disease (MELD) score was evaluated for hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi).Methods: The 30-day mortality of 166 hBV-DeCi patients was examined. Receiver operating characteristic curve analysis and multivariate regression analysis were used to assess the performance of NLR for prediction of poor outcomes.Results: The 30-day mortality rate was 10.2% (17/166). NLR was significantly lower in survivors than in non-survivors, and could be used for prognosis prediction in HBV-DeCi patients. Area under the curve was higher for NLR combined with MELD score than for each factor alone. (MELD score, AUC:0.864、NLR, AUC:0.781, Combined, AUC:0.920) The Odds ratio of MELD score is lower than NLR.(MELD score:1.447&NLR:1.745).Conclusions: The findings demonstrate that NLR combined with MELD score has a high prognostic value for HBV-DeCi patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"43-49"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer. 18F-FDG PET/CT代谢参数对非小细胞肺癌淋巴结转移的预测价值

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.1080/17520363.2024.2443379

Xiaopeng Yu, Jianlin Wang, Liqun Huang, Long Xie, Yingrui Su

{"title":"Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer.","authors":"Xiaopeng Yu, Jianlin Wang, Liqun Huang, Long Xie, Yingrui Su","doi":"10.1080/17520363.2024.2443379","DOIUrl":"10.1080/17520363.2024.2443379","url":null,"abstract":"Background: Lymph node metastasis is closely associated with the prognosis of patients with non-small cell lung cancer (NSCLC). This study aimed to evaluate the role of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters in mediastinal lymph node metastasis in NSCLC.Methods: One hundred patients with NSCLC who underwent surgery, systematic lymph node dissection, who had undergone 18FFDG PET/CT for initial staging were divided into two groups: lymph node metastasis and non-metastasis. The maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), SUV in the liver (SURliver), mediastinal blood pool (SURblood), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were detected in both groups. Receiver operating characteristic (ROC) curves were used to evaluate the parameters for predicting the diagnostic efficacy.Results: The SUVmax, SUVmean, SURblood, SURliver, MTV, and TLG were higher in the group with lymph node metastasis than in the group without lymph node metastasis. The ROC analysis showed that 18F-FDG PET/CT demonstrated acceptable predictive ability with AUC of 0.964 (95% CI, 0.930-0.998).Conclusions: The relative 18F-FDG PET/CT primary uptake and substitution parameters showed acceptable predictive efficacy for mediastinal lymph node metastasis in patients with NSCLC. Additional, SURblood has potential for clinical application.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"35-41"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of the Naples prognostic score for no-reflow phenomenon after saphenous vein graft stenting. 那不勒斯预后评分对隐静脉支架植入术后无血流现象的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-22 DOI: 10.1080/17520363.2024.2443383

Cemalettin Yılmaz, Ahmet Karaduman, Muhammet Mücahit Tiryaki, Büşra Güvendi Şengör, Tuba Unkun, Barkın Kültürsay, Regayip Zehir

{"title":"Predictive value of the Naples prognostic score for no-reflow phenomenon after saphenous vein graft stenting.","authors":"Cemalettin Yılmaz, Ahmet Karaduman, Muhammet Mücahit Tiryaki, Büşra Güvendi Şengör, Tuba Unkun, Barkın Kültürsay, Regayip Zehir","doi":"10.1080/17520363.2024.2443383","DOIUrl":"10.1080/17520363.2024.2443383","url":null,"abstract":"Background: No-reflow is a critical adverse event associated with percutaneous coronary intervention (PCI), particularly during saphenous vein graft (SVG) procedures. The Naples Prognostic Score (NPS) reflects inflammatory status, but its relationship with no-reflow remains unclear. Therefore, we aimed to evaluate the relationship between NPS and no-reflow occurrence following SVG PCI.Methods: We retrospectively analyzed 286 patients who underwent SVG PCI from January 2020 to January 2024, with a median age of 65 years and 85.7% male. Participants were categorized into low NPS (0-2, 48.6%) and high NPS (3-4, 51.4%) groups. Two nested models were developed by adding NPS (continuous and categorical, respectively) to the base model.Results: Higher no-reflow rates were noted in the high-NPS group (48.5% vs. 9.5%, p < 0.05). Multivariable regression revealed that a higher NPS significantly increased no-reflow risk, with odds ratios of 5.966 (95% CI: 3.066-11.611) for continuous NPS and 10.110 (95% CI: 3.194-32.002) for categorical NPS. Adding NPS to the base model significantly improved predictive performance (likelihood-ratio test p < 0.001). Model 1 demonstrated the best performance (X2 : 84.857, R2 : 0.468) and discriminative ability (AUC: 0.888).Conclusion: Our findings suggest that NPS is a strong predictor of no-reflow following SVG PCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"13-22"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of D-dimer as a diagnostic and prognostic biomarker for acute pericarditis. 探讨d -二聚体作为急性心包炎诊断和预后生物标志物的潜力。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-28 DOI: 10.1080/17520363.2024.2448021

George Lazaros, Emilia Lazarou, Charalambos Vlachopoulos, Costas Tsioufis

引用次数: 0