Biomarkers in medicine最新文献_第5页

Meta-analysis of preoperative CALLY index for predicting the prognosis of cancer. 术前CALLY指数预测肿瘤预后的meta分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-06 DOI: 10.1080/17520363.2025.2600696

Congying Li, Wenlong Zhou, Xin Zhao, Yanli Sun, Jianfeng Zang, Shujing Wang

{"title":"Meta-analysis of preoperative CALLY index for predicting the prognosis of cancer.","authors":"Congying Li, Wenlong Zhou, Xin Zhao, Yanli Sun, Jianfeng Zang, Shujing Wang","doi":"10.1080/17520363.2025.2600696","DOIUrl":"10.1080/17520363.2025.2600696","url":null,"abstract":"Objective: This study aims to evaluate the predictive value of the CALLY index in cancer prognosis via systematic review and meta-analysis.Methods: PubMed, Web of Science, Embase, and Cochrane were searched up to November 2024. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS), and meta-analysis was performed with STATA 17.0.Results: Among 21 cohort studies,the findings indicated that, regarding overall survival (OS), a low CALLY index was correlated with a 113% elevated likelihood of all-cause mortality compared to those with a higher CALLY index (risk ratio [RR] = 0.47, 95% confidence intervals [95%CI]: 0.42-0.53). An 85% elevated risk of disease-free survival (DFS) and relapse-free survival (RFS) was observed in individuals with a low CALLY index (pooled RR = 0.54, 95%CI: 0.46-0.63). Moreover, a lower CALLY index was correlated with a significantly greater tumor burden (standardized mean difference (SMD) = -0.64, 95%CI: -0.76-0.52). The stage-specific analysis demonstrated that a low CALLY index significantly increased the risk of cancer progression by 54% in individuals at stage II (RR = 0.65, 95%CI: 0.43-0.98) and by 67% in individuals at stage III (RR = 0.60, 95%CI: 0.43-0.86).Conclusion: The CALLY index independently predicts adverse cancer outcomes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1293-1304"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum periostin: a sentinel for malignancy risk in kidney transplant recipients. 血清骨膜素：肾移植受者恶性肿瘤风险的哨兵。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-19 DOI: 10.1080/17520363.2025.2595907

Anna Sączek, Krzysztof Batko, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Siek, Andrzej Kraśniak, Alina Bętkowska-Prokop, Katarzyna Krzanowska, Marcin Krzanowski

{"title":"Serum periostin: a sentinel for malignancy risk in kidney transplant recipients.","authors":"Anna Sączek, Krzysztof Batko, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Siek, Andrzej Kraśniak, Alina Bętkowska-Prokop, Katarzyna Krzanowska, Marcin Krzanowski","doi":"10.1080/17520363.2025.2595907","DOIUrl":"10.1080/17520363.2025.2595907","url":null,"abstract":"Background: Periostin (POSTN) is a matricellular protein involved in kidney fibrosis and inflammation but also linked to tumor progression and regulation of the local microenvironment.Aims: This study aimed to evaluate the association between serum POSTN, transgelin (TAGLN) and highly sensitive interleukin 6 (hsIL-6) and de novo malignancy occurrence post kidney transplant (KTx).Methods: Serum concentrations of POSTN, TAGLN, and hsIL-6 were measured in 127 KTRs and compared with 32 healthy controls. Patients were followed for a median (IQR) of 29 (25-32) months.Results: Log-transformed serum POSTN concentrations were lower in the KTx group (mean [SD]: 6.80[0.53] vs. 7.06[0.33] pmol/l), whereas transgelin (4.62[0.34] vs. 4.30[0.29] ng/mL) and hsIL-6 (1.51[0.50] vs. 0.99[0.37] pg/mL) were elevated (p < 0.001 for all). Final model showed satisfactory discrimination (AUC 0.83; 95% CI 0.74-0.91). Patients in the moderate POSTN zone were characterized higher odds of malignancy (OR 4.40; 95% CI 1.21-16.91, p = 0.011). Higher POSTN levels were independently associated with time post-KTx (β = 0.20; p < 0.001). Lower TAGLN levels were observed in older patients (β = -0.005; p = 0.011), those with CV disease (β = -0.200; p = 0.008) and among smokers (β = -0.19; p = 0.026).Conclusions: In patients post-KTx, elevated serum POSTN is an independent predictor of new-onset malignancy. Further prospective evaluation is warranted.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1199-1209"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of miR-21 and miR-486 in clock-guided minimally invasive surgery for pulmonary nodules. miR-21和miR-486在时钟引导下肺结节微创手术中的预测价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-09 DOI: 10.1080/17520363.2025.2595913

Zheng Wang, Wei Yan, Qiang Wang, Huining Liu, Qiang Liu, Qing Tian, Zhijie Li, Jinfeng Liu, Yingchun Ren

{"title":"Predictive value of miR-21 and miR-486 in clock-guided minimally invasive surgery for pulmonary nodules.","authors":"Zheng Wang, Wei Yan, Qiang Wang, Huining Liu, Qiang Liu, Qing Tian, Zhijie Li, Jinfeng Liu, Yingchun Ren","doi":"10.1080/17520363.2025.2595913","DOIUrl":"10.1080/17520363.2025.2595913","url":null,"abstract":"Objective: This study evaluated the prognostic significance of miR-21 and miR-486 expression in patients undergoing clock-guided minimally invasive surgery for pulmonary nodules.Methods: In this prospective cohort study, intraoperative tissues from 138 lung cancer patients were analyzed. MiRNA expression was quantified via RT-qPCR, and patients were stratified into high- and low-expression groups using ROC-determined cutoffs. Postoperative outcomes, including residual nodule characteristics and survival, were monitored.Results: At 6 months postoperatively, the high-expression group demonstrated significantly larger residual nodules (1.06 vs. 0.73 cm, p < 0.001), higher density (p = 0.003), and elevated metabolic activity (p = 0.014). This group also experienced shorter median overall survival (OS) (17.4 vs. 21.6 months, p = 0.003) and progression-free survival (PFS) (11.5 vs. 16.6 months, p = 0.012). In multivariable analysis, both miR-21 (HR = 1.75, p = 0.023) and miR-486 (HR = 1.68, p = 0.031) remained independent predictors of poor OS after adjusting for clinical covariates.Conclusion: Elevated miR-21 and miR-486 expression predicts aggressive tumor behavior and poor survival after precise nodule resection, highlighting their potential as biomarkers for postoperative risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1221-1225"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to comment on "Plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer". 回复关于“血浆源性circALG8和circCAMTA1作为非小细胞肺癌早期诊断指标”的评论。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-15 DOI: 10.1080/17520363.2025.2600708

Yufei Sheng, Lulu Yang, Boyang Wang, Zhiqi Hong, Jin Guo, Chengwei Zhou, Tao Li, Wentao Hu, Zhaohui Gong

引用次数: 0

An update on colorectal cancer biomarkers: exploring the roles of c-Jun and IL-8. 结直肠癌生物标志物的最新进展：探讨c-Jun和IL-8的作用

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-06 DOI: 10.1080/17520363.2025.2597174

Nur Rahadiani, Marini Stephanie, Kathryn Effendi, Amelia Fossetta Manatar, Ening Krisnuhoni

{"title":"An update on colorectal cancer biomarkers: exploring the roles of c-Jun and IL-8.","authors":"Nur Rahadiani, Marini Stephanie, Kathryn Effendi, Amelia Fossetta Manatar, Ening Krisnuhoni","doi":"10.1080/17520363.2025.2597174","DOIUrl":"10.1080/17520363.2025.2597174","url":null,"abstract":"Objective: Colorectal cancer (CRC) is a major contributor to global cancer mortality. Reliable biomarkers like c-Jun and Interleukin-8 (IL-8) may improve prognosis and therapy. Considering the possible ethnic differences in CRC biomarkers, this study is the first to examine a distinct Southeast Asian cohort (Indonesia).Methods: A retrospective study analyzed 98 CRC patients using immunohistochemistry to evaluate c-Jun and IL-8 expression. Paraffin-embedded tissues were assessed for correlations with clinicopathological features. Statistical analyses were performed with p < 0.05 considered significant.Results: c-Jun expression was significantly higher in mucinous or serrated histology (median 1.80, range 0.90-2.30) compared to adenocarcinoma, NOS (median 1.60, range 0.70-2.50) (p = 0.04). Meanwhile, IL-8 expression showed no significant differences across all clinicopathological factors. Neither biomarkers showed significant association with most clinicopathological factors, including age, sex, tumor size, location, stage, grade, invasion, or metastasis.Conclusions: c-Jun and IL-8 expression showed limited prognostic relevance for most clinicopathological features of CRC. However, elevated c-Jun expression may indicate its particular involvement in distinct CRC subtype pathogenesis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1227-1238"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel miRNA set for screening gastric cancer with high sensitivity: an ROC analysis of 6,997 samples. 新型高灵敏度胃癌筛查miRNA: 6997份样本的ROC分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-07 DOI: 10.1080/17520363.2025.2600246

Jun Wang, Shilian Le, Sien Wu, Qi Yang, Senglin Wen, Gen Huang, Peng Deng

{"title":"Novel miRNA set for screening gastric cancer with high sensitivity: an ROC analysis of 6,997 samples.","authors":"Jun Wang, Shilian Le, Sien Wu, Qi Yang, Senglin Wen, Gen Huang, Peng Deng","doi":"10.1080/17520363.2025.2600246","DOIUrl":"10.1080/17520363.2025.2600246","url":null,"abstract":"Aims: Cancer screening is essential for reducing GC-associated deaths. Nonetheless, implementing population-based screening strategies poses challenges. In this study, a comprehensive receiver operating characteristic (ROC) analysis was conducted on 2565 microRNAs (miRNAs) from 6997 samples to identify a classifier for GC screening.Method: First, batch effects were corrected across the five Gene Expression Omnibus Series (GSE) datasets. Second, a predictive model was established using the incidence method. Finally, this model was validated using randomly selected datasets, all datasets after batch effect removal, and each of the datasets separately.Results: Six miRNAs, namely miR-1290, miR-5100, miR-1343-3p, miR-8073, miR-4706, and miR-4787-3p were identified, with an area under the ROC curve (AUC) of 0.990 ± 0.002, 0.993 ± 0.002, 0.996 ± 0.004, 0.978 ± 0.010, 0.957 ± 0.015, and 0.969 ± 0.015, respectively. The miRNA set obtained by combining the six miRNAs yielded an AUC of 0.997 ± 0.001, which was higher than that of the six individual miRNAs (p < 0.001). Validation across the total dataset and five GSE datasets (GSE106817, GSE112264, GSE113486, GSE113740, and GSE164174) yielded AUCs of 0.997, 0.999, 1.000, 1.000, 0.996, and 0.994, respectively.Conclusion: The novel miRNA set comprising miR-1290, miR-5100, miR-1343-3p, miR-8073, miR-4706, and miR-4787-3p holds promise as a diagnostic classifier for GC screening.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1305-1312"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sweat-prints of COVID-19: unique metabolite signatures. COVID-19的汗印：独特的代谢物特征

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-14 DOI: 10.1080/17520363.2025.2600706

Snehal Bhumkar, Manjari Jonnalagadda, Khushman Taunk, Srikanth Rapole, Richa Ashma, Suresh Gosavi

{"title":"Sweat-prints of COVID-19: unique metabolite signatures.","authors":"Snehal Bhumkar, Manjari Jonnalagadda, Khushman Taunk, Srikanth Rapole, Richa Ashma, Suresh Gosavi","doi":"10.1080/17520363.2025.2600706","DOIUrl":"10.1080/17520363.2025.2600706","url":null,"abstract":"Aim: The study of human sweat and its metabolite profile can reveal important metabolic processes. Metabolites produced during respiratory infections, such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), create unique odor signatures. This study aims to identify a distinct signature of SARS-CoV-2 infection through the analysis of sweat metabolites.Material and methods: Sweat samples were collected from the axillae of individuals during the Delta and Omicron pandemic waves. Samples represent symptomatic (ventilator; n = 49), asymptomatic (home quarantine; n = 46) patients, and healthy individuals (n = 50) from Pune district, Maharashtra. Sweat metabolites were extracted under acidic conditions and analyzed using gas chromatography-mass spectrometry (GC-MS) with the NIST library and a hit threshold of 80%. The identified compounds were assessed for their origins and metabolic roles.Results: Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) revealed distinct clustering of the groups. We report six compounds-6-ethyl-2-methyl decane, tetradecane, styrene, 2-ethyl-1-hexanol, 2-methyl heptane, and 1-ethoxy pentane-specifically in infected individuals.Conclusion: Alkanes and their derivatives were significantly abundant in the symptomatic cohort and linked to inflammatory lung conditions as compared to healthy controls, thus affirming the presence of a distinct sweat metabolite profile in SARS-CoV-2 symptomatic individuals.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1267-1275"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for recurrence of intrauterine adhesions after hysteroscopic adhesiolysis: a retrospective study. 宫腔镜下粘连松解术后子宫内粘连复发的生物标志物：一项回顾性研究。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-10 DOI: 10.1080/17520363.2025.2595906

De-Lai Long, Xiao-Dong Fan, Ying-Jun Zhu

{"title":"Biomarkers for recurrence of intrauterine adhesions after hysteroscopic adhesiolysis: a retrospective study.","authors":"De-Lai Long, Xiao-Dong Fan, Ying-Jun Zhu","doi":"10.1080/17520363.2025.2595906","DOIUrl":"10.1080/17520363.2025.2595906","url":null,"abstract":"Objective: To evaluate the predictive value of peripheral blood inflammatory biomarkers - Systemic Immune-Inflammation Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR) - for recurrence risk of intrauterine adhesion (IUA) following hysteroscopic adhesiolysis.Methods: This retrospective study included 170 patients who underwent hysteroscopic adhesiolysis for IUA between October 2022 and October 2024. Within a 6-month follow-up based on their recurrence status, the patients were categorized into recurrence (R-IUA, n = 60) and non-recurrence (Non-IUA, n = 110) groups. SII, NLR, and PLR levels were assessed preoperatively, 24 hours postoperatively, and on postoperative day 7. Dynamic changes (δSII, δNLR, δPLR) were calculated. ROC curves assessed predictive performance, and logistic regression identified independent risk factors, which were incorporated into a nomogram model.Results: The R-IUA group had significantly higher levels of SII and NLR at all time points, with δSII showing the strongest predictive accuracy (AUC > 0.85). Multivariate analysis identified δSII, δNLR, amenorrhea, curettage history, and lack of intrauterine stent as independent predictors. The nomogram incorporating these factors achieved an AUC of 0.89.Conclusion: Dynamic inflammatory biomarkers, especially δSII and δNLR, are effective predictors of IUA recurrence and may guide individualized postoperative management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1189-1197"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum KLRB1 (CD161) as a discriminative biomarker in community-acquired pneumonia. 血清KLRB1 （CD161）作为社区获得性肺炎的鉴别生物标志物

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-10 DOI: 10.1080/17520363.2025.2600247

Buğra Kerget, Ferhan Kerget, Hatice Beyza Özkan, Esra Laloğlu

{"title":"Serum KLRB1 (CD161) as a discriminative biomarker in community-acquired pneumonia.","authors":"Buğra Kerget, Ferhan Kerget, Hatice Beyza Özkan, Esra Laloğlu","doi":"10.1080/17520363.2025.2600247","DOIUrl":"10.1080/17520363.2025.2600247","url":null,"abstract":"Aims: This study aimed to evaluate serum levels of killer cell lectin-like receptor B1 (KLRB1, CD161) as a biomarker for distinguishing between viral and bacterial causes in patients with community-acquired pneumonia (CAP).Materials & methods: A total of 120 individuals were enrolled between November 2024 and January 2025: 46 with viral pneumonia, 44 with bacterial pneumonia, and 30 healthy controls. Serum KLRB1 levels were measured using ELISA. Microbiological cultures, PCR testing, and serology were used to classify pneumonia etiology. Additional laboratory and radiological data were collected.Results: Streptococcus pneumoniae and Influenza A H1N1 were the most common agents for bacterial and viral pneumonia, respectively. KLRB1, CRP, and leukocyte levels were significantly higher in bacterial cases than viral ones (p < 0.001). KLRB1 levels were also significantly higher in healthy controls compared to both pneumonia groups. ROC analysis showed a KLRB1 cutoff of 5.11 ng/mL yielded 97% sensitivity and 85% specificity in distinguishing bacterial from viral pneumonia.Conclusions: Serum KLRB1 may serve as a valuable biomarker to differentiate between viral and bacterial CAP, supporting early diagnosis and optimized treatment decisions.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1285-1292"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galectin-3 in single ventricle physiology: insights into fibrosis and functional impairment after Fontan procedure. 半凝集素-3在单心室生理学：对Fontan手术后纤维化和功能损害的见解。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-12-01 Epub Date: 2025-12-15 DOI: 10.1080/17520363.2025.2601393

Małgorzata Kowalczyk, Mirosław Kowalski

{"title":"Galectin-3 in single ventricle physiology: insights into fibrosis and functional impairment after Fontan procedure.","authors":"Małgorzata Kowalczyk, Mirosław Kowalski","doi":"10.1080/17520363.2025.2601393","DOIUrl":"10.1080/17520363.2025.2601393","url":null,"abstract":"Introduction: Galectin-3 (Gal-3) is a biomarker associated with myocardial fibrosis, a key factor in the dysfunction of the functionally single ventricle (FSV) in patients after the Fontan procedure. This study aimed to evaluate the relationship between serum Gal-3 levels and echocardiographic and cardiopulmonary exercise parameters in this population.Methods: Thirty-seven patients (23 males, 14 females) with Fontan circulation were included. All underwent speckle-tracking echocardiography (STE), cardiopulmonary exercise testing (CPET), and serum Gal-3 measurement using ELISA. Correlations between Gal-3 and clinical, echocardiographic, and CPET parameters were analyzed.Results: Gal-3 levels correlated positively with patient age and time since Fontan completion (p < 0.05). No significant associations were found between Gal-3 and ejection fraction, global longitudinal strain (GLS), or free wall strain. However, Gal-3 showed a significant correlation with the transmural strain gradient (p < 0.05). No association was observed between Gal-3 and CPET parameters, including peak VO2.Conclusions: Galectin-3 may reflect fibrotic remodeling of the FSV, as suggested by its correlation with the transmural strain gradient. The absence of a relationship with exercise capacity highlights the complexity of Fontan-related dysfunction. Gal-3 shows promise as a noninvasive biomarker of myocardial fibrosis in this unique patient group.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1277-1283"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0