Biomarkers in medicine最新文献_第4页

The Syn-D study: detection of cutaneous phosphorylated alpha-synuclein in mild cognitive impairment a trial protocol. Syn-D研究：轻度认知障碍患者皮肤磷酸化α -突触核蛋白检测试验方案。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-16 DOI: 10.1080/17520363.2025.2520154

Christopher H Gibbons, Douglas Galasko, Daniel Press, Daniel Claassen, Todd Levine, Roy Freeman

{"title":"The Syn-D study: detection of cutaneous phosphorylated alpha-synuclein in mild cognitive impairment a trial protocol.","authors":"Christopher H Gibbons, Douglas Galasko, Daniel Press, Daniel Claassen, Todd Levine, Roy Freeman","doi":"10.1080/17520363.2025.2520154","DOIUrl":"10.1080/17520363.2025.2520154","url":null,"abstract":"Background: Skin biopsies have >95% sensitivity and specificity to detect the presence of phosphorylated alpha-synuclein (P-SYN).Objective: To determine the frequency of cutaneous P-SYN in patients with mild cognitive impairment (MCI) due to suspected Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).Design, setting and participants: The Syn-D study is a multicenter prospective clinical trial from ~10 centers across the United States that includes patients with MCI-AD or MCI-DLB.Methods: Patients will undergo skin biopsies for detection of P-SYN and plasma biomarkers for ptau-217 to determine biomarker positivity rates at the MCI stage and will be followed longitudinally to determine final clinical diagnosis as defined by an expert panel of clinicians blinded to biomarker results.Main outcomes and measures: The co-primary outcomes include: 1) The sensitivity of skin biopsy detection of P-SYN in patients with clinical diagnoses of MCI due to DLB or AD at baseline and at 12-month follow-up 2) To report the frequency with which cutaneous deposition of P-SYN and blood-based AD biomarkers co-exist in a population of patients with MCI.Discussion: This will be the first in-vivo study to determine the co-existence of biomarkers for both diseases as a surrogate for co-pathology.Trial registration: NCT05479552.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"501-508"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing. 促氧化-抗氧化平衡作为死亡率的预测因子：来自Neyshabur衰老纵向研究的发现。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1080/17520363.2025.2521253

Seyed Reza Mirhafez, Zeinab Shateri Amiri, Atena Mansouri, Saeed Mohammadian Haftcheshmeh, Peyman Habibi, Fatemeh Abdollahi, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

{"title":"Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing.","authors":"Seyed Reza Mirhafez, Zeinab Shateri Amiri, Atena Mansouri, Saeed Mohammadian Haftcheshmeh, Peyman Habibi, Fatemeh Abdollahi, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar","doi":"10.1080/17520363.2025.2521253","DOIUrl":"10.1080/17520363.2025.2521253","url":null,"abstract":"Background: The aim of this study was to determine PAB levels as a predictor of all-cause and cause-specific mortality in adult and elderly subjects.Methods: The data from 386 subjects who had died during the study were age- and sex-matched to 386 subjects that remained alive, and PAB levels were compared. PAB was evaluated using a mixed enzymatic/chemical method involving simultaneous oxidation and reduction of the chromogen 3,3',5,5'-tetramethylbenzidine by prooxidants and antioxidants, respectively, leading to measurable colorimetric changes.Results: PAB levels showed an increased risk of mortality (OR: 1.018; 95%CI: 1.010-1.025, p < 0.001) for each unit increase of PAB (per SD increase). When divided into quartiles, the PAB value was significantly higher for all-cause mortality in quartiles 2,3 and 4 compared with quartile 1 (PAB <34.95). Using uni & multivariate conditional logistic regression with multiple adjustments, the PAB value remained significantly different for all-cause mortality. The result of the cause-specific mortality analysis showed that the mean PAB was highest in COVID-19 infection and the respiratory diseases, and lowest in death caused by cardiovascular diseases (p < 0.05).Conclusions: Increasing PAB levels were significantly associated with increasing all-cause mortality suggesting that PAB measurement may have utility in indicating disease severity and have differential prognostic value in acute and chronic clinical scenarios.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"551-559"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the multifaceted role and therapeutic potential of Sulf-2 in human tumor biology. 阐明硫-2在人类肿瘤生物学中的多方面作用和治疗潜力。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-22 DOI: 10.1080/17520363.2025.2521254

Huanyan Peng, Man Liu, Songkang Liu, Chun Ning, Dongye Yang

{"title":"Elucidating the multifaceted role and therapeutic potential of Sulf-2 in human tumor biology.","authors":"Huanyan Peng, Man Liu, Songkang Liu, Chun Ning, Dongye Yang","doi":"10.1080/17520363.2025.2521254","DOIUrl":"10.1080/17520363.2025.2521254","url":null,"abstract":"Sulf-2, a key member of the sulfatase family, regulated tumor progression, invasion, and metastasis through various mechanisms including genetic alterations, epigenetic modifications, transcriptional regulation, and microenvironmental influences. The dysregulation of Sulf-2 has been implicated as a pivotal driver in the development of numerous tumors. The lack of a comprehensive understanding of Sulf-2 enzymatic activities has limited the advancement of research progress, largely due to the intricate modulation of heparan sulfate (HS) biology by this enzyme. In this review, we will comprehensively discuss the structure, function, and regulatory mechanisms of Sulf-2, elucidated the mechanisms of Sulf-2 in different human-type tumors. Furthermore, we would summarize the potential applications and limitations of Sulf-2 as a target in combining therapies for human tumors, providing insights that could be instrumental in advancing targeted cancer treatments. Our comprehensive review will shed light on the multifaceted role and therapeutic potential of Sulf-2 in human tumor biology.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"561-570"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mean corpuscular volume (MCV) is a hematological biomarker associated with COVID-19 mortality risk. 平均红细胞体积（MCV）是与COVID-19死亡风险相关的血液学生物标志物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1080/17520363.2025.2523235

Víctor Bernal-Dolores, José Manuel Reyes-Ruiz, Kim Rodríguez-Relingh, Gustavo Martínez-Mier

{"title":"The mean corpuscular volume (MCV) is a hematological biomarker associated with COVID-19 mortality risk.","authors":"Víctor Bernal-Dolores, José Manuel Reyes-Ruiz, Kim Rodríguez-Relingh, Gustavo Martínez-Mier","doi":"10.1080/17520363.2025.2523235","DOIUrl":"10.1080/17520363.2025.2523235","url":null,"abstract":"Aim: This study aimed to investigate the role of mean corpuscular volume (MCV) as a predictor of mortality due to COVID-19.Materials and methods: This retrospective, single-center, and longitudinal study included 122 patients with COVID-19.Results: Compared to the survivor's group, the non-survivors had higher MCV (92.13 ± 3.67 fL), neutrophil-to-lymphocyte ratio [NLR] (16.99 [21.31]), platelet-to-lymphocyte ratio [PLR] (350.33 [304.68]), and systemic immune-inflammation index [SII] (3684.92 [4073.25]) levels (p < 0.05 for all). The optimal cutoff values for predicting in-hospital COVID-19 mortality, determined by the Youden index, indicated that patients with MCV > 89 fL, NLR > 8.69, PLR > 418.08, or SII > 2149.36 were at a higher risk of death due to SARS-CoV-2 infection. The area under the curves (AUC) of NLR, SII, MCV, and PLR was sufficient for accurate prediction. COVID-19 patients with MCV > 89 fL and PLR > 418.08 were 3.65 (95% CI 1.03-12.87; p = 0.043) and 5.08 (95% CI 1.06-24.22; p = 0.041) times more likely to die than those without these values, respectively. MCV was positively correlated with age, mean corpuscular hemoglobin (MCH), urea, blood urea nitrogen (BUN), and creatinine.Conclusion: MCV > 89 fL and PLR > 418.08 at the time of hospital admission were associated with an increased COVID-19 mortality risk.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"577-587"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the diagnostic efficacy of serum DR-70 and its combination with CEA in lung cancer. 血清DR-70及其联合CEA对肺癌的诊断价值评价。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-07-11 DOI: 10.1080/17520363.2025.2525071

Xuena Wang, Xianda Wei, Zifeng Cheng, Xu Zhou, Xiaoyun Lei, Wen Zhao, Qiuxing Tao, Zhilüe Lü, Hua Lin, Baoheng Gui

{"title":"Evaluation of the diagnostic efficacy of serum DR-70 and its combination with CEA in lung cancer.","authors":"Xuena Wang, Xianda Wei, Zifeng Cheng, Xu Zhou, Xiaoyun Lei, Wen Zhao, Qiuxing Tao, Zhilüe Lü, Hua Lin, Baoheng Gui","doi":"10.1080/17520363.2025.2525071","DOIUrl":"10.1080/17520363.2025.2525071","url":null,"abstract":"Objective: To evaluate the diagnostic value of DR-70 immunoassay and its combination with carcinoembryonic antigen (CEA) measurement for detecting lung malignancies.Methods: Serum concentrations of carcinoembryonic antigen (CEA) and DR-70 were quantitatively assessed using electrochemiluminescence immunoassay (ECLIA) and enzyme-linked immunosorbent assay (ELISA), in 110 patients diagnosed with primary lung cancer, 48 patients with pulmonary benign lesions, and 164 healthy subjects.Results: Serum levels of both DR-70 and CEA showed statistically significant differences between lung cancer patients and healthy controls (p < 0.001). The study found that the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC), for DR-70 alone were 71.8%, 84.2%, 70.5%, 85.7%, and 0.836, respectively, which was superior to the values of 62.7%, 68.3%, 49.6%, 78.6%, 0.689 for CEA alone. The values for the combination of DR-70 and CEA were 87.3, 55.7%, 50.0%, 89.8%, and 0.846. The combination method significantly improved the sensitivity, NPV and AUC while concurrently reducing specificity and PPV, compared to DR-70 or CEA alone.Conclusion: Individual serum DR-70 testing and the combined DR-70+CEA panel exhibited robust diagnostic efficacy in lung adenocarcinoma detection.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 14","pages":"605-611"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis. 急性呼吸窘迫综合征患者肺超声评分与死亡风险的相关性：一项荟萃分析。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1080/17520363.2025.2529770

Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao

{"title":"Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis.","authors":"Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao","doi":"10.1080/17520363.2025.2529770","DOIUrl":"10.1080/17520363.2025.2529770","url":null,"abstract":"Purpose: To clarify the relationship of lung ultrasound score (LUS) with the risk of mortality in patients with acute respiratory distress syndrome (ARDS).Methods: Several electronic databases were searched up to 14 October 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined to assess the relationship between LUS and mortality in ARDS patients. Subgroup analysis stratified by the age and grouping method by LUS were further performed. Sensitivity analysis was performed to assess the stability of pooled results and Begg's funnel plot and Egger's test were applied to detect publication bias.Results: Sixteen studies with 1762 patients were included. Overall pooled results demonstrated that elevated LUS was significantly related to increased risk of mortality among ARDS patients (OR = 2.29, 95% CI: 1.45-3.63, P < 0.001). Besides, subgroup analysis stratified by the age (adult: OR = 2.01, p = 0.004; child: OR = 15.29, P < 0.001) and grouping method by LUS (dichotomous: OR = 5.60, p = 0.001; continuous: OR = 1.65, P < 0.001) revealed similar results. Sensitivity analysis indicated that pooled results were stable and Begg's funnel plot and Egger's test (p = 0.946) manifested that no significant publication bias was observed.Conclusion: Our meta-analysis indicates that a higher LUS is significantly associated with increased risk of mortality in ARDS patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"629-635"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality. 血清白蛋白的表型特异性动态及其对败血症死亡率的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1080/17520363.2025.2521251

Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann

{"title":"Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality.","authors":"Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann","doi":"10.1080/17520363.2025.2521251","DOIUrl":"10.1080/17520363.2025.2521251","url":null,"abstract":"Aims: To assess the prognostic value of serial serum albumin measurements in septic patients, with a focus on different clinical phenotypes.Methods: We conducted a prospective observational study involving 254 patients with sepsis admitted to an Intermediate Care Unit in Italy (September 2022-June 2024). Patients were classified into four sepsis phenotypes (α, β, γ, δ), and serum albumin levels were measured daily over five days. The primary outcome was 30-day mortality. Logistic regression, Cox models, and AUROC analysis were used to evaluate associations between albumin dynamics, phenotypes, and outcomes.Results: The δ phenotype showed the lowest mean albumin levels (2.2 g/dL) and the highest mortality (45.4%), while phenotype α had the highest albumin and lowest mortality (3.6%). Each 1 g/dL increase in albumin was associated with a 63% mortality risk reduction (HR 0.37; 95% CI: 0.24-0.56). Albumin's predictive performance was strongest in the δ phenotype (AUROC up to 0.95).Conclusion: Serial albumin monitoring may provide prognostic insights in sepsis, especially in phenotypes associated with endothelial dysfunction. These results are hypothesis-generating and may support more personalized treatment strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"529-537"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis. 基于生物信息学的hsa-miR-4651和hsa-miR-608作为诊断矽肺的新型生物标志物的预测。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.1080/17520363.2025.2520160

Jing Wu, Yimin Shi, Cuiyun Zuo, Yaping Xu, Ying Wu, Haiyan Gong, Yanyan Ke, Xue Yi

{"title":"Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis.","authors":"Jing Wu, Yimin Shi, Cuiyun Zuo, Yaping Xu, Ying Wu, Haiyan Gong, Yanyan Ke, Xue Yi","doi":"10.1080/17520363.2025.2520160","DOIUrl":"10.1080/17520363.2025.2520160","url":null,"abstract":"Objective: Based on GEO database and bioinformatics to screen silicosis-related differentially expressed genes and analyze the biological functions, in order to provide new ideas and methods for the treatment of silicosis fibrosis.Methods: We predicted microRNAs related to silicosis through bioinformatics and verified the expression of microRNAs in patients with silicosis and healthy people by Real-time Fluorescence Quantitative PCR.Results: Three key genes (LCN2, MMP9, and CCL2) were identified, with hsa-miR-4651, hsa-miR-608, and hsa-miR-3151-5p predicted as their regulatory miRNAs. Hsa-miR-4651 and hsa-miR-608 were significantly upregulated in silicosis patient plasma, indicating their potential as biomarkers for silicosis diagnosis.Conclusions: Hsa-miR-4651 and hsa-miR-608 were identified as potential novel biomarkers for silicosis diagnosis, offering new insights for clinical diagnosis and treatment of silicosis fibrosis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"517-527"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and monitoring of breast cancer with a novel circulating tumor cells enrichment device. 一种新型循环肿瘤细胞富集装置在乳腺癌诊断和监测中的应用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-22 DOI: 10.1080/17520363.2025.2521255

Zhiyun Gong, Jing Yan, Yi Zhang, Yan Chen, Aoshuang Li, Xiaorong Yang, Weizhong Shi, Lin Guo, Tiantian Dai, Feng Dong, Renquan Lu

{"title":"Diagnosis and monitoring of breast cancer with a novel circulating tumor cells enrichment device.","authors":"Zhiyun Gong, Jing Yan, Yi Zhang, Yan Chen, Aoshuang Li, Xiaorong Yang, Weizhong Shi, Lin Guo, Tiantian Dai, Feng Dong, Renquan Lu","doi":"10.1080/17520363.2025.2521255","DOIUrl":"10.1080/17520363.2025.2521255","url":null,"abstract":"Aims: Circulating tumor cells (CTCs) are a critical biomarker for cancer evaluation. The more excellent detection system for CTCs is in demand.Patients & methods: One hundred and thirty-seven breast cancer patients, 97 patients with benign breast diseases, and 42 healthy volunteers were enrolled. Four milliliters of peripheral blood was used for CTCs detection. The performance was assessed by the receiver operator characteristic curve. A short-term follow-up with 23 patients was presented for real-time monitoring.Results: In clinical, CTCs were found in 96.35% of patients with malignant breast cancer and 25.77% of patients with benign breast diseases but not in healthy group, by CytoBot® 2000. The sensitivity and specificity of 89.8% and 98.6%, respectively, when the cutoff value of 1.5 CTCs per 4 ml whole blood. Significant differences of CTC count were found between malignant and nonmalignant group (p < 0.0001), tumor progression (p < 0.0001), and tumor size (p < 0.0001). In follow-up, 82.61% of patients exhibited a reduction in CTC count, which corresponds with medical observation that benefits from treatment. Additionally, CD45+ positive CTC showed with anomalous pattern during treatment.Conclusion: CTCs and this platform both have practical implications in clinical breast cancer diagnosis and monitoring.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"539-550"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing the association between MPO levels and glaucoma severity. 分析MPO水平与青光眼严重程度的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI: 10.1080/17520363.2025.2523236

Lingling Chen, Jinxia Wang, Yanping Gao, Wenbo Xiu, Zuo Wang, Gao Zhang, An Li, Yang Chen, Bolin Deng, Fang Lu, Chong He, Lijuan Hu

{"title":"Analyzing the association between MPO levels and glaucoma severity.","authors":"Lingling Chen, Jinxia Wang, Yanping Gao, Wenbo Xiu, Zuo Wang, Gao Zhang, An Li, Yang Chen, Bolin Deng, Fang Lu, Chong He, Lijuan Hu","doi":"10.1080/17520363.2025.2523236","DOIUrl":"10.1080/17520363.2025.2523236","url":null,"abstract":"Aim: To explore the relationship between plasma myeloperoxidase (MPO) and glaucoma, assessing the clinical utility of MPO in glaucoma.Methods: A cross-sectional study involved 127 glaucoma patients and 106 healthy controls. Plasma MPO markers were quantified using enzyme-linked immunosorbent assay (ELISA), comparing levels between glaucoma patients and healthy controls, and analyzing plasma MPO across different glaucoma severity grades.Results: In this study, we observed elevated plasma MPO levels in glaucoma patients (p < 0.001). After correcting for confounders such as age, sex, hypertension, and diabetes, plasma MPO remained independently associated with glaucoma (OR = 1.05, 95% CI: 1.04-1.07, p < 0.001). Plasma MPO may reflect the severity of glaucoma, with significant differences in plasma MPO observed between early and severe stages, but not in the moderate stages. In addition, elevated plasma MPO was associated with higher cup-to-disc ratios. ROC curve analysis demonstrated the validity of glaucoma markers in identifying early glaucoma from severe glaucoma (early versus severe: AUC = 0.633).Conclusion: Elevated plasma MPO levels are independently associated with glaucoma risk, suggesting it might provide insight into disease pathogenesis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"597-604"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0