Biomarkers in medicine最新文献_第4页

Correction. 修正。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1080/17520363.2024.2437843

引用次数: 0

Update prognostic potency of surfactant protein D (SP-D) in the COVID-19 landscape: an In-depth meta-analytical exploration. “表面活性剂蛋白D （SP-D）在COVID-19领域的最新预后效力：一项深入的荟萃分析探索”。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 DOI: 10.1080/17520363.2024.2432325

Mohammad-Navid Bastani, Shahram Jalilian, Seyed Sobhan Bahreiny, Manoochehr Makvandi, Mojtaba Aghaei, Zahra Mansouri, Negin Karamali, Tannaz Sakhavarz, Mahdi Amraei, Elnaz Harooni

{"title":"Update prognostic potency of surfactant protein D (SP-D) in the COVID-19 landscape: an In-depth meta-analytical exploration.","authors":"Mohammad-Navid Bastani, Shahram Jalilian, Seyed Sobhan Bahreiny, Manoochehr Makvandi, Mojtaba Aghaei, Zahra Mansouri, Negin Karamali, Tannaz Sakhavarz, Mahdi Amraei, Elnaz Harooni","doi":"10.1080/17520363.2024.2432325","DOIUrl":"10.1080/17520363.2024.2432325","url":null,"abstract":"Introduction: Surfactant Protein D (SP-D), a key component of the innate immune system, has attracted significant interest for its potential role in the pathophysiology and prognosis of COVID-19. This systematic review and meta-analysis aim to clarify the prognostic importance of SP-D levels in COVID-19 patients.Methods: A comprehensive literature search was conducted using PubMed, Web of Science, Cochrane Library, Scopus, EMBASE, and Google Scholar, covering studies published from January 2000 to January 2024. The inclusion criteria focused on studies measuring SP-D levels in the serum or plasma of COVID-19 patients, comparing severe and non-severe cases. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model to assess overall effect sizes. Meta-regressions and subgroup analyses were performed to identify potential sources of heterogeneity, including patient age, assay techniques, and gender ratio.Results: The meta-analysis incorporated data from nine studies involving 5,410 COVID-19 patients. Elevated SP-D levels were significantly correlated with increased disease severity, yielding an SMD of 0.642 (95% CI: 0.314 to 0.870; p = 0.012).Conclusion: This meta-analysis confirms the prognostic significance of SP-D in the context of COVID-19. Elevated SP-D levels are associated with severe disease outcomes, highlighting its potential as a prognostic biomarker.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1135-1148"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of CK-MB on the curative effect of urokinase combined with LMWH calcium in AMI. CK-MB对尿激酶联合 LMWH钙治疗急性心肌梗死疗效的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-24 DOI: 10.1080/17520363.2024.2429367

Hongbin Tang, Yong Liu, Yabing Yu, Jun Zhou, Jiaomei Yang

{"title":"The predictive value of CK-MB on the curative effect of urokinase combined with LMWH calcium in AMI.","authors":"Hongbin Tang, Yong Liu, Yabing Yu, Jun Zhou, Jiaomei Yang","doi":"10.1080/17520363.2024.2429367","DOIUrl":"10.1080/17520363.2024.2429367","url":null,"abstract":"Objective: This study investigates the predictive value of CK-MB in treating acute myocardial infarction (AMI) with urokinase combined with low molecular weight heparin (LMWH) calcium.Methods: AMI patients treated at our hospital from April 2020 to August 2022 were included in this prospective, multi-center cohort study. Patients were randomly assigned to a urokinase group or a combined treatment group (urokinase plus LMWH). CK-MB levels were measured using ELISA, and adverse reactions were recorded. The accuracy of CK-MB as a predictor was evaluated via ROC curve analysis and AUC.Results: Before treatment, CK-MB levels were similar in both groups (p > 0.05). Post-treatment, levels were significantly lower in the combined group (p < 0.05). The combined group had a higher proportion of mild CK-MB elevation and lower moderate/severe elevations (p < 0.05). Adverse reaction rates were similar (p > 0.05). The combined treatment group showed higher effectiveness (p < 0.05), with better sensitivity (94%) and specificity (82%) than the urokinase group (sensitivity 89%, specificity 78%).Conclusion: CK-MB is a valuable predictor for evaluating the efficacy of urokinase plus LMWH in AMI treatment, offering advantages in reducing CK-MB levels and improving outcomes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1087-1092"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-glycan as new potential biomarker for predicting treatment response in patients with type 2 diabetes mellitus. N-糖是预测 2 型糖尿病患者治疗反应的潜在生物标记物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1080/17520363.2024.2432309

Hui-Jun Dong, Xiao-Hui Li, Qi-Xin Gu, Chi-Fa Ma, Ming-Xia Yuan, Zhen-Zi Wang, Jian-Rong Su, Lei Xu, Cui-Ying Chen, Qiqige Ebule, Hui Zhuang, Xue-En Liu

{"title":"N-glycan as new potential biomarker for predicting treatment response in patients with type 2 diabetes mellitus.","authors":"Hui-Jun Dong, Xiao-Hui Li, Qi-Xin Gu, Chi-Fa Ma, Ming-Xia Yuan, Zhen-Zi Wang, Jian-Rong Su, Lei Xu, Cui-Ying Chen, Qiqige Ebule, Hui Zhuang, Xue-En Liu","doi":"10.1080/17520363.2024.2432309","DOIUrl":"10.1080/17520363.2024.2432309","url":null,"abstract":"Aims: To investigate the N-glycans related to the metformin efficacy in patients with type 2 diabetes mellitus (T2DM).Materials and methods: We enrolled 141 healthy controls and 195 newly diagnosed T2DM patients treated with metformin for 3 months. Serum N-glycan profile was determined by DNA sequencer - assisted fluorophore-assisted carbohydrate electrophoresis (DSA-FACE). The N-glycan model was established by logistic regression analysis. Receiver operating characteristic curve (ROC) analysis was used to analyze the predictive power of the N-glycan model for metformin efficacy.Results: The abundances of several N-glycans in serum of T2DM patients at baseline were significantly different from those of healthy controls and tended to recover the N-glycan of controls after 3 months treatment. Serum N-glycans changes were more significant in the good response group (FPG <7 mmol/L) after metformin treatment. In addition, the abundance of peak9 at baseline had an opposite tendency between HbA1c increased and decreased groups post-treatment, which could be a biomarker for predicting metformin efficacy. Peak9 combined with other 11 N-glycans at baseline was used to establish the predictive model to distinguish non-response from response patients (AUROC = 0.780, sensitivity = 70.6% and specificity = 77.5%).Conclusions: Serum N-glycans may have potential value as biomarkers for indicating the efficacy of metformin.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1113-1122"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM35B as a novel biomarker for diagnosing gliomas. TMEM35B 作为诊断胶质瘤的新型生物标记物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1080/17520363.2024.2431480

Gongbo Liang, Xuwen Lai, Guangning Yan, Wenyuan He, Longjun Su, Jinxia Luo, Zhuocai Wang

引用次数: 0

Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study. 免疫营养指数与类风湿关节炎的疾病活动性相关：一项横断面研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1080/17520363.2024.2430942

Özlem Kılıç, Duygu Tecer, Muhammed Canbaş, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz

{"title":"Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study.","authors":"Özlem Kılıç, Duygu Tecer, Muhammed Canbaş, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz","doi":"10.1080/17520363.2024.2430942","DOIUrl":"10.1080/17520363.2024.2430942","url":null,"abstract":"Aim: This study aimed to evaluate the relationship between immune nutrition indices and disease activity in rheumatoid arthritis (RA).Methods: The current study included a cross-sectional analysis of 90 age and gender-matched healthy controls and 116 RA patients who satisfied the 2010 American College of Rheumatology and European League Against Rheumatism categorization criteria. Patients were categorized into remission (disease activity score 28- erythrocyte sedimentation rate (DAS 28-ESR) <2.6) and active disease (DAS 28-ESR ≥2.6) groups.Results: Systemic immune-inflammatory index (SII), controlling nutritional status (CONUT), and fibrinogen-to-albumin ratio (FAR) were higher in the RA group than in controls, whereas CRP-albumin-lymphocyte ratio (CALLY) and prognostic nutrition index (PNI) were considerably lower in RA (p < 0.001). The clinical and simplified disease activity index, DAS 28-ESR had negative correlation with PNI and CALLY (p < 0.001). PNI and CALLY were independently related markers of disease activity (p < 0.001) by regression analysis. According to receiver operating characteristic curve analysis, the ideal cutoff values for the active disease are as follows: CONUT, 0.5; CALLY, 12.5, SII, 579.43, FAR, 90.43, and PNI, 40. CALLY was the most sensitive (84.06%) and specific marker (95.74%).Conclusions: CALLY and PNI may be useful prognostic markers for assessing disease activity in RA patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1093-1102"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methemoglobin in critically ill septic patients. 重症脓毒症患者体内的高铁血红蛋白。

IF 2.2 4区医学

Biomarkers in medicine Pub Date : 2024-09-13 DOI: 10.1080/17520363.2024.2395246

Atthaphong Phongphithakchai,Akinori Maeda,Yukiko Hikasa,Sofia Spano,Nuttapol Pattamin,Anis Chaba,Glenn Eastwood,Helen Young,Leah Peck,Rinaldo Bellomo

引用次数: 0

Systemic immune-inflammation and prognostic immune nutritional index in oral squamous cell carcinoma patients. 口腔鳞状细胞癌患者的全身免疫炎症和预后免疫营养指数

IF 2.2 4区医学

Biomarkers in medicine Pub Date : 2024-09-13 DOI: 10.1080/17520363.2024.2394390

Zhenzhen Li,Shaowen Ge,Chi Song,Yaning Li,Xiaofei Xie,Li Xu,Shengkai Liao,Kai Zhang

引用次数: 0

Comparison of inflammatory markers for the prediction of atrial fibrillation recurrence following cryoablation. 冷冻消融术后预测心房颤动复发的炎症标志物比较。

IF 2.2 4区医学

Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2395236

Koray Kalenderoglu,Mert Ilker Hayiroglu,Tufan Cinar,Melih Oz,Gokcem Ayan Bayraktar,Ridvan Cam,Kadir Gurkan

引用次数: 0

NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients. NEAT1和CHROMR lncRNAs：弥漫大B细胞淋巴瘤（尤其是老年患者）的有望诊断工具。

IF 2.2 4区医学

Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389036

Ali Rajabi,Ali Saber,Joost Kluiver,Anke van den Berg,Mohammad Ali Hosseinpourfeizi,Reza Safaralizadeh

引用次数: 0