Biomarkers in medicine最新文献_第4页

Thrombophilia-related gene variants may be linked to polycystic ovary syndrome susceptibility and its related traits. 血栓相关基因变异可能与多囊卵巢综合征易感性及其相关性状有关。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-01 DOI: 10.1080/17520363.2026.2697763

Roshan Dadachanji, Sushma Khavale, Nanda Joshi, Anushree Patil, Srabani Mukherjee

{"title":"Thrombophilia-related gene variants may be linked to polycystic ovary syndrome susceptibility and its related traits.","authors":"Roshan Dadachanji, Sushma Khavale, Nanda Joshi, Anushree Patil, Srabani Mukherjee","doi":"10.1080/17520363.2026.2697763","DOIUrl":"10.1080/17520363.2026.2697763","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women having both gynecological and metabolic comorbidities. PCOS increases the risk of cardiovascular and thromboembolic diseases due to heightened prothrombotic states, suggesting shared genetic determinants with thrombophilia. In addition, convergence of these polymorphisms to insulin resistance, a hallmark feature of PCOS, may exacerbate PCOS risk and further intensify hypercoagulability-associated metabolic and reproductive manifestations.Methods: This case-control study explores the association between MTHFR (C677T), FGB (-148C/T, -249C/T, -455G/A), FXIII (V34L), and FV (FVL, rs6020) and risk of PCOS development and its related traits in PCOS (n = 475) and control (n = 245) women. Clinical, biochemical, and hormonal parameters were estimated for all study participants and genotyping was carried out by direct sequencing.Results: To the best of our knowledge, this is the first time that FGB promoter polymorphisms (-148C/T and -455G/A) were investigated and showed nominal association with reduced risk of PCOS prior to multiple testing correction. Additionally, potential genotype-phenotype trends with metabolic and hormonal parameters were noted in both controls and women with PCOS, with and without insulin resistance.Conclusion: Genetic profiling of thrombophilia-related gene polymorphisms could help monitoring and management of PCOS and its related reproductive and metabolic complications.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"595-611"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in cardiovascular biomarkers: innovations in early detection, risk prediction, and treatment monitoring. 心血管生物标志物的最新进展：早期检测、风险预测和治疗监测方面的创新。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-05 DOI: 10.1080/17520363.2026.2714195

Kyle Roethlin, Hira Usman, Zeeshan Ahmed

{"title":"Recent advances in cardiovascular biomarkers: innovations in early detection, risk prediction, and treatment monitoring.","authors":"Kyle Roethlin, Hira Usman, Zeeshan Ahmed","doi":"10.1080/17520363.2026.2714195","DOIUrl":"10.1080/17520363.2026.2714195","url":null,"abstract":"Cardiovascular disease (CVD) is a major source of morbidity and mortality across the globe. Effective screening and risk stratification of patients can improve long‑term outcomes by allowing physicians to offer fine-tuned advice and treatments. Advances in technology have enabled the study of various biomarkers associated with CVD, allowing researchers to study the molecular processes underlying illness. In this study, we sampled recent advances in the application of Machine Learning (ML) techniques to transcriptome datasets of CVD patients in the hopes of progressing our understanding of underlying pathophysiology, improving our ability to detect disease, and refining our methods of risk stratification of patients. These studies suggest that ML algorithms may help identify complex relationships within high-dimensional datasets to isolate relationships within datasets that were previously missed, enhancing our understanding of disease. However, there are several challenges that need to be addressed before these innovations can reach the clinic. Researchers must verify their results via means that are readily obtainable for physicians and must adequately identify the indications for a particular test so they can integrate into preexisting workflows. We offer potential solutions and suggestions to these issues so that these approaches may eventually contribute to improved patient care.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"723-731"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis. Circ_0024085和circ_0000339作为诊断强直性脊柱炎的潜在生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI: 10.1080/17520363.2026.2716195

Xin Li, Can Mu, Shenling Liao, Zehao Wang, Zhenzhen Su, Bin Yang

{"title":"Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis.","authors":"Xin Li, Can Mu, Shenling Liao, Zehao Wang, Zhenzhen Su, Bin Yang","doi":"10.1080/17520363.2026.2716195","DOIUrl":"10.1080/17520363.2026.2716195","url":null,"abstract":"Objective: This study aimed to identify novel circular RNA (circRNA) biomarkers in peripheral blood mononuclear cells (PBMCs) for the diagnosis of ankylosing spondylitis (AS) and to explore their potential pathogenic mechanisms.Methods: High-throughput circRNA sequencing was performed on PBMCs from 3 AS patients and 3 healthy controls. Differentially expressed circRNAs were validated by RT-qPCR in an independent cohort (64 AS patients and 24 healthy individuals). Diagnostic performance was evaluated via ROC curve analysis. Correlations between circRNA expression and clinical inflammatory markers were assessed. Bioinformatics analysis was employed to predict target miRNAs and enriched signaling pathways.Results: A total of 53 circRNAs were differentially expressed in AS PBMCs. Among these, circ_0024085 and circ_0000339 were significantly upregulated in AS (41.6-fold and 27.0-fold, p < 0.05), and demonstrated good diagnostic performance (AUC = 0.815 for the combination). The expression of Circ_0024085 was inversely correlated with erythrocyte sedimentation rate (ESR, p = 0.005) and monocyte count (p = 0.027). Bioinformatic analysis indicated that the target miRNAs of circ_0024085 were significantly enriched in the IL‑4/IL‑13 signaling pathway, while those of circ_0000339 were enriched in the SEMA4D signaling pathway.Conclusion: Our findings identify circ_0024085 and circ_0000339 as potential diagnostic biomarkers for AS. With bioinformatics predictions indicating that Circ_0024085 may exert an anti-inflammatory effect via M2 macrophage polarization, whereas circ_0000339 might contribute to bone damage through SEMA4D signaling.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"663-671"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical validity of CD20 as a biomarker in breast cancer patients using tissue microarrays and whole slide sections. 利用组织微阵列和整片切片分析CD20作为乳腺癌患者生物标志物的有效性。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-07 DOI: 10.1080/17520363.2026.2714196

Demet Özcan, Patricia Switten Nielsen, Jan Alsner, Trine Tramm

{"title":"Analytical validity of CD20 as a biomarker in breast cancer patients using tissue microarrays and whole slide sections.","authors":"Demet Özcan, Patricia Switten Nielsen, Jan Alsner, Trine Tramm","doi":"10.1080/17520363.2026.2714196","DOIUrl":"10.1080/17520363.2026.2714196","url":null,"abstract":"Background: Clinical utility of biomarker-based treatment depends on both analytical and clinical validity. CD20+ B-lymphocytes often form nodular lymphoid structures within tumors, presenting potential analytical issues if using tissue microarrays (TMA). We compared CD20 expression in TMAs and whole-slide sections (WS) using digital image analysis.Materials and methods: Immunohistochemical CD20+ expression was assessed on 1 TMA core/patient and corresponding WS from 221 breast cancer patients. CD20+ area fractions were quantified within four spatial tissue compartments: (1) tumor epithelium; (2) tumor margin; (3) tumor-related stroma; (4) total tumor area. Bland-Altman analysis and t-test compared CD20+ area fractions of WS and TMA.Results: CD20+ cells were predominantly located in the stroma and often formed nodules. Across all compartments, the absolute area fraction of CD20+ was significantly lower in TMAs than in WS. Mean ratios of CD20+ area fractions (WS vs. TMA) ranged from 2.5 (95% confidence interval: 1.7-3.6; p < 0.001) to 6.4 (4.7-8.9; p < 0.001) within the four spatial regions.Conclusions: These findings indicate that TMAs may underestimate the presence of CD20+ cells in breast cancer, presumably due to the formation of nodules. This heterogeneity in distribution is important to consider when exploring the use of CD20 as a potential clinical biomarker.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"705-713"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-virus interaction between IFN-γ rs2069705 polymorphism and Epstein-Barr virus in breast cancer susceptibility among Egyptian women. IFN-γ rs2069705多态性与Epstein-Barr病毒在埃及妇女乳腺癌易感性中的基因-病毒相互作用

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1080/17520363.2026.2716197

Noha E Ibrahim, Mahmoud A W Khader, Mohamed M S Farag, Fatima G Yehia, Amal M El-Feky

{"title":"Gene-virus interaction between IFN-γ rs2069705 polymorphism and Epstein-Barr virus in breast cancer susceptibility among Egyptian women.","authors":"Noha E Ibrahim, Mahmoud A W Khader, Mohamed M S Farag, Fatima G Yehia, Amal M El-Feky","doi":"10.1080/17520363.2026.2716197","DOIUrl":"10.1080/17520363.2026.2716197","url":null,"abstract":"Aims: This study investigated the association between Epstein-Barr virus (EBV) infection and breast cancer (BC) susceptibility and evaluated the role of interferon-gamma (IFN-γ) rs2069705 polymorphism in disease risk and clinicopathological characteristics among Egyptian women.Materials and methods: A case-control study was conducted on 96 histologically confirmed BC patients and 50 age-matched healthy controls. EBV serostatus was assessed by ELISA detection of anti-viral capsid antigen IgG antibodies. IFN-γ rs2069705 (A/G) genotyping was performed using TaqMan real-time PCR assays.Results: EBV seropositivity was significantly higher in BC patients (93.75%) than controls (p = 0.008). Significant associations were observed between IFN-γ rs2069705 polymorphism and BC susceptibility, particularly for AA and AG genotypes and A and G alleles (p < 0.001), whereas the GG genotype showed no significant association. AA and AG genotypes were also associated with unfavorable clinicopathological features.Conclusion: EBV infection and IFN-γ rs2069705 polymorphism may contribute to BC susceptibility and progression among Egyptian women and could serve as potential combined biomarkers for risk assessment and prognosis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"673-683"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum LDH, eosinophils, and IgE in atopic dermatitis severity: a retrospective study. 血清乳酸脱氢酶、嗜酸性粒细胞和IgE与特应性皮炎严重程度的关系：一项回顾性研究。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-30 DOI: 10.1080/17520363.2026.2697764

Fan Bai, Wanlong Yu, Yabo Xu, Li Wang, Mingjun Lei, Zan Tian, Xiumei Cheng

{"title":"Serum LDH, eosinophils, and IgE in atopic dermatitis severity: a retrospective study.","authors":"Fan Bai, Wanlong Yu, Yabo Xu, Li Wang, Mingjun Lei, Zan Tian, Xiumei Cheng","doi":"10.1080/17520363.2026.2697764","DOIUrl":"10.1080/17520363.2026.2697764","url":null,"abstract":"Aims: To evaluate serum lactate dehydrogenase (LDH), eosinophils, and total immunoglobulin E (IgE) as accessible adjunctive markers of atopic dermatitis (AD) severity.Materials & methods: This retrospective study included 265 AD patients and 97 healthy controls. SCORAD scores and laboratory biomarkers obtained within 48 hours were analyzed using ordinal logistic regression. A binary logistic model was used for ROC analysis of severe AD.Results: Severe AD was associated with higher LDH, eosinophil counts, and total IgE than mild-moderate AD. LDH and eosinophils correlated with SCORAD scores (r = 0.61 and r = 0.45, both p < 0.001), while IgE showed a significant non-linear quadratic trend (p < 0.001). Older age, longer disease course, LDH, eosinophils, total IgE, and personal atopy (OR = 2.94) were independently associated with greater severity. The combined biomarker model yielded an AUC of 0.88 for severe AD.Conclusion: LDH, eosinophils, and total IgE were independently associated with SCORAD-defined AD severity. Their combined assessment may complement, but not replace, clinical scoring; prospective validation is required.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"621-626"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary glycemic index/glycemic load and knee osteoarthritis: associations with inflammation and oxidative stress. 膳食血糖指数/血糖负荷与膝关节骨关节炎：与炎症和氧化应激的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.1080/17520363.2026.2692040

Farshad Amirkhizi, Filiz Mercantepe, Soudabeh Hamedi-Shahraki, Aleksandra Klisic

{"title":"Dietary glycemic index/glycemic load and knee osteoarthritis: associations with inflammation and oxidative stress.","authors":"Farshad Amirkhizi, Filiz Mercantepe, Soudabeh Hamedi-Shahraki, Aleksandra Klisic","doi":"10.1080/17520363.2026.2692040","DOIUrl":"10.1080/17520363.2026.2692040","url":null,"abstract":"Aims: Although dietary glycemic index (GI) and glycemic load (GL) are known to affect inflammation and oxidative balance, their roles in OA are unclear. This study aims to investigate the relationship between dietary GI and GL with inflammation, oxidative stress, and clinical symptoms in patients with knee osteoarthritis (KOA).Patients and methods: In a cross-sectional study, 160 patients diagnosed with KOA were included. Dietary intake was assessed using a validated food frequency questionnaire, and daily GI and GL values were calculated. Clinical symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Results: Higher dietary GI and GL were significantly associated with increased serum levels of malondialdehyde (MDA), total oxidant status (TOS), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP), as well as with decreased total antioxidant capacity (TAC). Dietary GI and GL were positively correlated with the total WOMAC score, as well as with the WOMAC physical activity and stiffness.Conclusion: High dietary GI and GL may be associated with oxidative stress and inflammatory responses, and may worsen clinical symptoms in KOA patients. Nutritional strategies emphasizing low-GI/GL diets may contribute to better symptom control and disease management in KOA.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"483-493"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin resistance‑associated adipokine and oxidative stress profiles in women with polycystic ovary syndrome. 多囊卵巢综合征女性胰岛素抵抗相关脂肪因子和氧化应激谱

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-08 DOI: 10.1080/17520363.2026.2685081

Hiba Muwafaq Saleem, Hussein Riyadh Abdul Kareem Al-Hetty, Hanan Yousif Rasheed, Ruaa Abdulazez Mohammed

{"title":"Insulin resistance‑associated adipokine and oxidative stress profiles in women with polycystic ovary syndrome.","authors":"Hiba Muwafaq Saleem, Hussein Riyadh Abdul Kareem Al-Hetty, Hanan Yousif Rasheed, Ruaa Abdulazez Mohammed","doi":"10.1080/17520363.2026.2685081","DOIUrl":"10.1080/17520363.2026.2685081","url":null,"abstract":"Background: Although polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder among reproductive-aged women, the integrated role of adipokines in linking metabolic and hormonal dysfunction remains incompletely understood.Objective: The study aims to evaluate the associations between lipid profile alterations, selected adipokines (resistin, galectin-3, and apelin), oxidative stress markers, and the insulin resistance index (HOMA-IR) in women with PCOS compared to controls.Methods: This case-control study included 85 women with PCOS and 55 age-matched controls. Anthropometric and clinical data were collected. Levels of lipid profiles, adipokines, oxidative stress markers, and HOMA-IR were measured. Group comparisons and correlation analyses were performed.Results: Women with PCOS demonstrated elevated levels of resistin, galectin-3, and apelin compared to the controls, with respective measurements of 3.55 ± 0.52 vs 1.07 ± 0.34, 10.01 ± 1.76 vs 3.49 ± 1.03, and 289.23 ± 20.08 vs 191.31 ± 31.30), respectively. MDA exhibited a significant increase, whereas TAC was significantly reduced in the PCOS group. HOMA-IR showed significant positive associations with lipid profiles, adipokines, and levels of MDA, and an inverse correlation with HDL and TAC.Conclusion: The findings support the concept that altered adipokine levels and oxidative stress indices may reflect underlying metabolic dysfunction in women with PCOS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"495-502"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation. CALLY指数对经导管主动脉瓣置入术患者的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.1080/17520363.2026.2692041

Serkan Aslan, Ali Rıza Demir, Gökhan Demirci, Emre Aydın, Merve Yükselen Aydın, Begüm Uygur, Hicaz Zencirkiran Ağuş, Arda Güler, Serkan Kahraman, Gamze Babür Güler, Mehmet Ertürk

{"title":"Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation.","authors":"Serkan Aslan, Ali Rıza Demir, Gökhan Demirci, Emre Aydın, Merve Yükselen Aydın, Begüm Uygur, Hicaz Zencirkiran Ağuş, Arda Güler, Serkan Kahraman, Gamze Babür Güler, Mehmet Ertürk","doi":"10.1080/17520363.2026.2692041","DOIUrl":"10.1080/17520363.2026.2692041","url":null,"abstract":"Aims: The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite biomarker reflecting inflammation, nutritional status, and immune response. This study evaluated the association of the CALLY index with all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI).Methods: In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan-Meier analyses.Results: Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681-0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49-4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37-4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84-4.88) (all p < 0.001). Kaplan-Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001).Conclusion: The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"519-530"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of blood urea nitrogen-creatinine ratio for rehospitalization and outcomes in myocardial infarction: a four-year retrospective cohort analysis. 血尿素氮-肌酐比值对再住院和心肌梗死预后的预测价值：一项四年回顾性队列分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-07-03 DOI: 10.1080/17520363.2026.2697755

Atiyeh Ebrahimi, Arsalan Salari, Bahare Gholami-Chaboki, Amirhossein Borghei, Seyedeh Fatemeh Mirrazeghi, Seyed Mehdi Mousavi, Yasaman Borghei

{"title":"Prognostic value of blood urea nitrogen-creatinine ratio for rehospitalization and outcomes in myocardial infarction: a four-year retrospective cohort analysis.","authors":"Atiyeh Ebrahimi, Arsalan Salari, Bahare Gholami-Chaboki, Amirhossein Borghei, Seyedeh Fatemeh Mirrazeghi, Seyed Mehdi Mousavi, Yasaman Borghei","doi":"10.1080/17520363.2026.2697755","DOIUrl":"10.1080/17520363.2026.2697755","url":null,"abstract":"Background: Risk stratification in acute myocardial infarction (AMI) remains a critical challenge in clinical practice. Traditional prognostic markers often require complex or costly assessments, underscoring the need for simple, accessible indicators. This study, conducted with the aim of evaluating the relationship between the blood urea nitrogen (BUN) and creatinine (Cr) ratio and rehospitalization following AMI.Methods: This retrospective cohort study, conducted at a single center, patients diagnosed with AMI. BUN and Cr levels at the time of initial admission were collected to calculate the BUN/Cr ratio, which was categorized into two groups: ≤16.23 and >16.23. Statistical analyses were carried out using IBM SPSS software (version 22).Results: Among 1147 AMI patients, 53% had BUN/Cr ≤16.23 and 42.1% >16.23. Over four years, rehospitalization rates were slightly higher in the high BUN/Cr group but not statistically significant (p > 0.05). Primary outcomes differed significantly, with mortality notably higher in patients with elevated BUN/Cr ratios (3.7% vs. 1.1%) (p < 0.05).Conclusion: While rehospitalization rates over a four‑year period were slightly higher among those with elevated ratios, the difference was not statistically significant. However, patients with a BUN/Cr ratio >16.23 demonstrated markedly increased rates of major adverse cardiac events (MACE) compared to those with lower ratios.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"503-509"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0