Biomarkers in medicine最新文献_第3页

The prognostic role of circulating DNA markers in patients with lung malignancies: a systematic review and meta-analysis. 循环DNA标记物在肺恶性肿瘤患者中的预后作用：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-08-18 DOI: 10.1080/17520363.2025.2548190

Sayedeh-Zahra Kazemi-Harikandei, Mohammad-Reza Salmani Jelodar, Gholamreza Roshandel, Seyed Mohammad Tavangar

{"title":"The prognostic role of circulating DNA markers in patients with lung malignancies: a systematic review and meta-analysis.","authors":"Sayedeh-Zahra Kazemi-Harikandei, Mohammad-Reza Salmani Jelodar, Gholamreza Roshandel, Seyed Mohammad Tavangar","doi":"10.1080/17520363.2025.2548190","DOIUrl":"10.1080/17520363.2025.2548190","url":null,"abstract":"Aims: We aimed to explore the prognostic role of circulating DNA-related markers to improve clinical decision-making in patients with lung malignancies.Methods: A systematic search was performed on PubMed, Scopus, and Web of Science.Results: About 133 articles were included, comprising 5750 EGFR-positive, 1583 ALK-positive, and 9657 patients without specified genetic groups. Circulating tumor DNA (ctDNA) response was a significant prognostic marker associated with improved overall survival (OS) (HR = 0.36 [0.27, 0.47], I2 = 0%) and progression-free survival (PFS) (HR = 0.31 [0.18, 0.55], I2 = 67.33%) in advanced non-small cell lung cancer (NSCLC). Meta-analysis of tumor mutational burden (TMB) in the same group demonstrated trends toward poorer survival outcomes for higher TMB -pooled HR of 1.63 (95%-CI: 0.92, 2.88, I2 = 71.23%) for OS and 1.09 (95%-CI: 0.63, 1.89, I2 = 86.66%) for PFS. Finally, meta-analysis in advanced EGFR-positive NSCLC implicated significant prognostic effect of EGFR response positivity on OS and PFS -pooled HR of 0.39 and 0.27, respectively.Conclusion: Circulating DNA markers entailed valuable information in patient prognostication and depicting treatment efficacies in lung cancer. Further studies are needed to decipher more robust criteria for the presently accepted markers - namely ctDNA and EGFR response measures. Additionally, there are several markers - i.e. TMB - that have more exploratory clinical benefits.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"793-806"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel inflammatory markers based on complete blood count and PBMV success in rheumatic mitral stenosis. 基于全血细胞计数和PBMV成功治疗风湿性二尖瓣狭窄的新型炎症标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-07-27 DOI: 10.1080/17520363.2025.2538425

Nima Ghavamikia, Mohammad Sahebjam, Tahereh Davarpasand, Yaser Jenab

{"title":"Novel inflammatory markers based on complete blood count and PBMV success in rheumatic mitral stenosis.","authors":"Nima Ghavamikia, Mohammad Sahebjam, Tahereh Davarpasand, Yaser Jenab","doi":"10.1080/17520363.2025.2538425","DOIUrl":"10.1080/17520363.2025.2538425","url":null,"abstract":"Background: Inflammatory markers are associated with the severity of disease and outcomes in rheumatic mitral stenosis (RMS). This study explored the connection between newer inflammatory indices - specifically, the systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) - and clinical outcomes in RMS patients who underwent percutaneous balloon mitral valvuloplasty (PBMV).Methods: A total of 131 patients with severe RMS who received PBMV at Tehran Heart Center between August 2015 and February 2021 were assessed. Inflammatory markers were measured prior to the procedure. Echocardiographic parameters, Wilkins scores, and complications were analyzed over a three-year follow-up period. ROC curves and multivariate logistic regression were employed to evaluate predictive associations.Results: The average age of participants was 47.9 years, and 79.4% were female. Lower systolic pulmonary pressure and younger age were associated with a greater success rate of PBMV. Frequent complications included mitral regurgitation (47.5%) and readmission (27.5%). Higher levels of NLR, MLR, SII, and SIRI were correlated with increased Wilkins scores. SIRI was an independent predictor of PBMV success.Conclusion: SIRI demonstrated the highest predictive capability for PBMV success, with 71% sensitivity and 80% specificity. It was also associated with complications and mid-term outcomes in severe RMS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"667-675"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-immune-inflammation value: a new predictor of cardiac scar in hospitalized myocarditis patients. 泛免疫炎症值：心肌炎住院患者心脏瘢痕的新预测指标

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-07-30 DOI: 10.1080/17520363.2025.2540771

Semih Kalkan, Serçin Özkök, İhsan Demirtaş, Ömer Fakih Türkmen, Ali Fuat Tekin, Mustafa Ozan Gürsoy, Ahmet Karaduman, Volkan Gürler

{"title":"Pan-immune-inflammation value: a new predictor of cardiac scar in hospitalized myocarditis patients.","authors":"Semih Kalkan, Serçin Özkök, İhsan Demirtaş, Ömer Fakih Türkmen, Ali Fuat Tekin, Mustafa Ozan Gürsoy, Ahmet Karaduman, Volkan Gürler","doi":"10.1080/17520363.2025.2540771","DOIUrl":"10.1080/17520363.2025.2540771","url":null,"abstract":"Background: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging indicates myocardial scarring and has prognostic value in myocarditis. The Pan-Immune-Inflammation Value (PIV) is a novel biomarker reflecting systemic inflammation; however, its association with LGE in myocarditis remains uninvestigated. This study aims to evaluate whether PIV levels can predict the presence of LGE in patients with myocarditis.Aims: We retrospectively analyzed 141 patients with myocarditis between 2021 and 2024. PIV, troponin levels, and other inflammatory markers were analyzed for their association with LGE.Results: LGE was observed in 68.8% of the patients, with a higher proportion of males in the LGE+ group. The LGE+ group showed significantly elevated levels of PIV (1.661.2 ± 22.269) and troponin (786.2 ± 10.711 ng/L) compared to the LGE- group. Multivariate regression analysis confirmed PIV (OR: 1.002, p = 0.005) and troponin (OR: 1.003, p = 0.001) as predictors of LGE. ROC analysis identified a PIV threshold of >1153.2, achieving 95% specificity with a positive predictive value of 92.9% for LGE presence.Conclusions: Our findings indicate that elevated PIV levels are significant predictors of LGE, suggesting that PIV may serve as a valuable tool in assessing risk and guiding follow-up strategies for patients with myocarditis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"647-656"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of sarcopenia and PET imaging metrics in metastatic non-squamous NSCLC. 肌少症和PET成像指标在转移性非鳞状NSCLC中的预测价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-08-03 DOI: 10.1080/17520363.2025.2540758

İsmet Seven, Mehmet Akif Karacan, Semanur Özsan Çelebi, İrfan Karahan, Kahraman Kapanşahin, Fahriye Tuğba Köş, Elif Özdemir, Doğan Uncu

{"title":"The predictive value of sarcopenia and PET imaging metrics in metastatic non-squamous NSCLC.","authors":"İsmet Seven, Mehmet Akif Karacan, Semanur Özsan Çelebi, İrfan Karahan, Kahraman Kapanşahin, Fahriye Tuğba Köş, Elif Özdemir, Doğan Uncu","doi":"10.1080/17520363.2025.2540758","DOIUrl":"10.1080/17520363.2025.2540758","url":null,"abstract":"Aim: Metastatic non-small cell lung cancer (NSCLC) patients face a poor prognosis, with a 5-year overall survival (OS) rate of under 10%. In this investigation, we examined the prognostic implications of sarcopenia and metabolic metrics obtained from 18F-FDG PET/CT imaging in individuals diagnosed with metastatic non-squamous NSCLC (nsNSCLC).Methods: The investigation included 124 individuals with metastatic nsNSCLC who underwent 18F-FDG PET/CT imaging on diagnosis. Sarcopenia was determined by evaluating the skeletal muscle index at the L3 vertebral level. Metabolic metrics obtained from 18F-FDG PET/CT imaging, maximum standard uptake, metabolic tumor volume, and total lesion glycolysis were measured for whole body lesions (SUVmax_WB, MTV_WB, and TLG_WB) and primary tumors (SUVmax_T, MTV_T, and TLG_T). Primary endpoints examined were OS and the rate of sarcopenia diagnosis.Results: Patients with sarcopenia, comprising 74.2% of the cohort, experienced a markedly reduced median OS of 4.7 months compared to 9.8 months in the non-sarcopenic cohort, which accounted for 25.8% of the population. Multivariate analysis revealed that sarcopenia, as well as metabolic metrics, including SUVmax_T, MTV_T, TLG_T, and SUVmax_WB, were independent predictors of OS in metastatic nsNSCLC patients.Conclusion: The presence of sarcopenia and unfavorable metabolic metrics on 18F-FDG PET/CT are linked to worse survival outcomes in metastatic nsNSCLC patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"707-716"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of combined detection of serum procalcitonin and C-reactive protein in early differential diagnosis of bacterial and viral pneumonia and analysis of related inflammatory response mechanisms. 联合检测血清降钙素原和c反应蛋白在细菌性和病毒性肺炎早期鉴别诊断中的临床疗效及相关炎症反应机制分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-07-31 DOI: 10.1080/17520363.2025.2538428

Rong Yu, Tang Yan, Jing He, Yuezi Hu, Hua Tang

{"title":"Clinical efficacy of combined detection of serum procalcitonin and C-reactive protein in early differential diagnosis of bacterial and viral pneumonia and analysis of related inflammatory response mechanisms.","authors":"Rong Yu, Tang Yan, Jing He, Yuezi Hu, Hua Tang","doi":"10.1080/17520363.2025.2538428","DOIUrl":"10.1080/17520363.2025.2538428","url":null,"abstract":"Background: Early distinction of bacterial etiology from viral causes represents a cornerstone for rational antimicrobial therapy. Through evaluation of dual-biomarker strategies, this investigation examined the diagnostic utility of simultaneous PCT and CRP measurement while elucidating underlying inflammatory pathways.Methods: A retrospective analysis encompassed 284 patients diagnosed with pneumonia (bacterial: n = 162, viral: n = 122) hospitalized during January 2023 through December 2024. Laboratory parameters including PCT, CRP, leukocyte counts, neutrophil proportions, IL-6, and TNF-α underwent comprehensive measurement. Diagnostic accuracy was evaluated through ROC analysis, with severity correlations systematically assessed.Results: Marked increases in inflammatory markers characterized the bacterial cohort (all parameters p < 0.001). Among single biomarkers, PCT demonstrated superior diagnostic capability (AUC = 0.892). When combined measurement was employed, PCT+CRP yielded optimal performance (AUC = 0.943, sensitivity 92.6%, specificity 89.3%). Positive correlations emerged between biomarker concentrations and clinical severity scores (PCT: r = 0.782, CRP: r = 0.743, both p < 0.001). Following multivariate adjustment, concurrent elevation of both markers emerged as the strongest independent correlate of bacterial etiology (OR = 8.74, 95% CI: 5.26-14.53, p < 0.001).Conclusion: The synergistic assessment of PCT with CRP surpasses individual marker performance for bacterial-viral pneumonia discrimination, capturing differential inflammatory cascades and severity stratification. This dual-biomarker strategy optimizes therapeutic decisions and antimicrobial governance.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"657-666"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction. 血浆免疫蛋白酶体预测st段抬高型心肌梗死冠状动脉侧支循环的价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.1080/17520363.2025.2520158

Zhao Ma, Meichen Sun, Baoen Zhang, Yifei Nie, Chenchen Tu, Xin Zhao, Huihua Li, Dongfeng Zhang, Xiantao Song, Hongjia Zhang

{"title":"The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction.","authors":"Zhao Ma, Meichen Sun, Baoen Zhang, Yifei Nie, Chenchen Tu, Xin Zhao, Huihua Li, Dongfeng Zhang, Xiantao Song, Hongjia Zhang","doi":"10.1080/17520363.2025.2520158","DOIUrl":"10.1080/17520363.2025.2520158","url":null,"abstract":"Objective: The immunoproteasome is linked to endothelial function and may act as a proangiogenic factor. This study explored its predictive value for coronary collateral circulation (CCC) in ST-elevation myocardial infarction (STEMI) patients.Methods: We enrolled 252 STEMI patients from April 2021 to April 2024. Plasma levels of LMP2, LMP7, and PSMB10 were measured using ELISA. ROC curves assessed predictive ability for good CCC. Univariate and multivariate logistic regression analyses identified predictors, and restricted cubic spline (RCS) analysis evaluated the dose-response relationship. Subgroup analysis was also conducted.Results: Patients with good CCC had significantly higher plasma levels of immunoproteasome components. Among them, LMP7 showed the best predictive value (AUC = 0.732), with an optimal cut-off of 3.824 ng/mL. Multivariate logistic regression confirmed LMP7 ≥3.824 ng/mL as an independent predictor for good CCC [OR = 7.914 (4.127-15.174)]. RCS analysis showed a J-shaped association: the odds of good CCC increased notably when LMP7 exceeded 3.824 ng/mL. Subgroup analyses supported these findings.Conclusion: Higher plasma immunoproteasome levels, especially LMP7 ≥3.824 ng/mL, were independently associated with good CCC in STEMI patients, suggesting its potential role as a biomarker of collateral development.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"509-516"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome. 血清ang1、ang1 -7和Mas水平作为阻塞性睡眠呼吸暂停综合征的潜在生物标志物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 DOI: 10.1080/17520363.2025.2525059

Gizem Çil, Ömer Araz, Buğra Kerget, Esra Laloglu, Alperen Aksakal, Elif Yılmazel Uçar, Leyla Sağlam

{"title":"Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome.","authors":"Gizem Çil, Ömer Araz, Buğra Kerget, Esra Laloglu, Alperen Aksakal, Elif Yılmazel Uçar, Leyla Sağlam","doi":"10.1080/17520363.2025.2525059","DOIUrl":"10.1080/17520363.2025.2525059","url":null,"abstract":"Aims: In obstructive sleep apnea (OSA), the balance between inflammatory and anti-inflammatory responses is disrupted. This study examined the association between serum angiotensin 1 (Ang 1), angiotensin 1-7 (Ang 1-7), and Mas receptor levels and OSA severity.Material and methods: A total of 190 subjects underwent polysomnography and serum analysis for Ang 1, Ang 1-7, and Mas using ELISA. Patients were classified into control, mild, moderate, and severe OSA groups based on AHI.Results: Ang 1-7, Ang 1, and serum Mas levels were significantly lower in moderate and severe OSA groups compared to control and mild OSA (p < 0.001). Negative correlations were found between these biomarkers and AHI (e.g. Ang 1-7: R = -0.597, p < 0.001). ROC analysis showed strong diagnostic performance: AUC was 0.864 for Ang 1-7, 0.873 for Ang 1, and 0.837 for Mas, with sensitivity of 98%, 98%, and 97%, respectively.Conclusion: Reduced levels of Ang 1-7, Ang 1, and Mas are associated with increased OSA severity. These biomarkers demonstrated high diagnostic value and may be useful in stratifying patients with moderate-to-severe OSA.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"613-621"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation of lncRNA ANRASSF1 is associated with the lymph node metastasis and H. pylori infection in gastric cancer. lncRNA ANRASSF1表达上调与胃癌淋巴结转移和幽门螺杆菌感染相关。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-07-07 DOI: 10.1080/17520363.2025.2529769

Negin Sadi Khosroshahi, Sama Akbarzadeh, Elaheh Malek Abbaslou, Ali Rajabi, Adel Abdi, Ali Saber, Amir Reza Pakmanesh, Reza Safaralizadeh

{"title":"Upregulation of lncRNA ANRASSF1 is associated with the lymph node metastasis and H. pylori infection in gastric cancer.","authors":"Negin Sadi Khosroshahi, Sama Akbarzadeh, Elaheh Malek Abbaslou, Ali Rajabi, Adel Abdi, Ali Saber, Amir Reza Pakmanesh, Reza Safaralizadeh","doi":"10.1080/17520363.2025.2529769","DOIUrl":"10.1080/17520363.2025.2529769","url":null,"abstract":"Background: Gastric cancer is the fifth most common malignancy worldwide. Early diagnosis of GC can increase survival rate and treatment outcome. In the present study, the expression of lncRNA ANRASSF1 was evaluated in gastric tumor tissues.Methods: One hundred and two pairs of gastric tumors and non-tumor tissues were collected from Tabriz International Valiasr Hospital, Iran. RNA was extracted, followed by cDNA synthesis. Expression of ANRASSF1 was assessed using real-time PCR method.Results: ANRASSF1 was significantly overexpressed in GC (p < 0.001). We found a significant association between ANRASSF1 expression and lymph node metastasis (p = 0.014), Helicobacter pylori infection (p = 0.029), and Lauren subtypes (p = 0.0001).Conclusion: LncRNA ANRASSF1 appears to have an oncogenic role in GC, and it may be regarded as a diagnosis and prognostic biomarker in patients with GC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"571-576"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination of coronary artery ectasia predictors in acute coronary syndrome. 急性冠脉综合征冠状动脉扩张预测因素的研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-22 DOI: 10.1080/17520363.2025.2523238

Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Murat Özmen, Mustafa Özkoç, Emrah Aksakal

{"title":"Examination of coronary artery ectasia predictors in acute coronary syndrome.","authors":"Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Murat Özmen, Mustafa Özkoç, Emrah Aksakal","doi":"10.1080/17520363.2025.2523238","DOIUrl":"10.1080/17520363.2025.2523238","url":null,"abstract":"Aim: Coronary artery ectasia (CAE) is localized or generalized dilatation of the coronary artery lumen. CAE is difficult to diagnose, treat, and manage and is associated with the risk of adverse cardiovascular events. In our study, we aimed to evaluate and compare these predictive parameters of CAE.Materials & methods: We conducted a study that involved analyzing patients who had underwent angiography for acute coronary syndrome. The patients were categorized into two groups based on the presence or absence of CAE. The Cox regression analysis considered significant predictors for CAE while assessing independent variables. ROC Curve analysis was used to evaluate the predictive capability of these variables for CAE, and area under the curve (AUC) values were compared.Results: 2279 patients included in the study were followed for an average of 498 days. Coronary ectasia was present in 5.35% of the patients. LDL/HDL ratio and lymphocyte count independently predicted CAE.Conclusion: In our study, low density lipoprotein/high density lipoprotein (LDL/HDL) ratio and lymphopenia were observed to independently predict CAE. LDL/HDL ratio obtained from standard blood tests can be used as a cost-effective and simple method to predict CAE, making a significant contribution to treatment planning, prognosis and patient follow-up.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"589-596"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil percentage-to-albumin ratio as a novel predictor of mortality in HBV-Related acute-on-chronic liver failure. 中性粒细胞百分比-白蛋白比率作为hbv相关急性-慢性肝衰竭死亡率的新预测因子

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-29 DOI: 10.1080/17520363.2025.2525072

Yulituzi Waili, Yang Xiang, WeiLin Mao

{"title":"Neutrophil percentage-to-albumin ratio as a novel predictor of mortality in HBV-Related acute-on-chronic liver failure.","authors":"Yulituzi Waili, Yang Xiang, WeiLin Mao","doi":"10.1080/17520363.2025.2525072","DOIUrl":"10.1080/17520363.2025.2525072","url":null,"abstract":"Background: HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high short-term mortality rate, making early prognosis vital. This study investigated the predictive value of the neutrophil percentage-to-albumin ratio (NPAR) in HBV-ACLF.Methods: This retrospective study analyzed consecutive patients hospitalized with HBV-ACLF to identify risk factors for 90-day mortality. Disease severity was assessed using the Model for End-Stage Liver Disease (MELD) score, and multivariate regression analysis was performed to identify independent risk factors for mortality.Results: A total of 189 patients with HBV-ACLF were included in the analysis. The 90-day mortality rate was 45.5%. Higher NPAR levels were markedly associated with an increased mortality risk and were identified as an independent predictor comparable to the MELD score. The combination of NPAR and MELD score provided better prognostic accuracy than use of either marker alone.Conclusions: NPAR is a valuable predictor of 90-day mortality in HBV-ACLF patients, and its combination with the MELD score improves prognostic accuracy.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"623-628"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0