Biomarkers in medicine最新文献_第3页

NLR as prognostic biomarker for metastatic renal cell carcinoma patients treated with cytoreductive nephrectomy.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1080/17520363.2025.2471746

Huanrui Liu, Senlin Li, Fan Zhang, Weiyang He, Xin Gou, Xu Zhang, Yongpeng Xie

{"title":"NLR as prognostic biomarker for metastatic renal cell carcinoma patients treated with cytoreductive nephrectomy.","authors":"Huanrui Liu, Senlin Li, Fan Zhang, Weiyang He, Xin Gou, Xu Zhang, Yongpeng Xie","doi":"10.1080/17520363.2025.2471746","DOIUrl":"10.1080/17520363.2025.2471746","url":null,"abstract":"Purpose: This study aimed to determine the prognostic value of preoperative Neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic renal cell carcinoma (mRCC) undergoing cytoreductive nephrectomy (CN).Methods: We retrospectively investigated the clinicopathological data of patients with mRCC from two Chinese hospitals (2008-2018). Patients were stratified and analyzed for survival prognosis using X-tile software, Kaplan-Meier curves, log-rank test, and univariate/multivariate Cox regression analyses.Results: The patients were divided into low NLR group (≤2.7) and high NLR group (>2.7) based on the optimal cutoff value of 2.7 obtained using the X-tile software, containing 137 and 93 patients, respectively. Kaplan - Meier analysis indicated that high NLR group had significantly inferior median progression-free survival (PFS) and overall survival (OS) than low NLR group (median PFS of 8.3 months vs. 17.9 months, p = 0.003 and median OS of 21.6 months vs. 45.1 months, p = 0.009). Multivariate Cox regression analysis showed that NLR was an independent prognostic factor for PFS (hazard ratio [HR], 1.4; 95% CI, 1.1-1.9; p = 0.022) and OS (HR, 1.5; 95% CI, 1.1-2.1; p = 0.015).Conclusions: Elevated preoperative NLR demonstrates significant association with poor survival in post-CN mRCC patients and may facilitate clinical decision-making.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"215-222"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI: 10.1080/17520363.2025.2463882

Patrycja Mołek-Dziadosz, Joanna Natorska, Paweł T Matusik, Wiktoria Wojciechowska, Marek Rajzer, Renata Rajtar-Salwa, Stanisław Bartuś, Andrzej Surdacki, Krzysztof P Malinowski, Aleksandra Lenart-Migdalska, Maria Olszowska, Michał Ząbczyk

{"title":"Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.","authors":"Patrycja Mołek-Dziadosz, Joanna Natorska, Paweł T Matusik, Wiktoria Wojciechowska, Marek Rajzer, Renata Rajtar-Salwa, Stanisław Bartuś, Andrzej Surdacki, Krzysztof P Malinowski, Aleksandra Lenart-Migdalska, Maria Olszowska, Michał Ząbczyk","doi":"10.1080/17520363.2025.2463882","DOIUrl":"10.1080/17520363.2025.2463882","url":null,"abstract":"Background: Atrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.Materials and methods: In 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.Results: AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.Conclusions: Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"157-164"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical relevance of HRR (hemoglobin to RDW) and RAR (RDW to albumin) in pericarditis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-01 Epub Date: 2025-02-27 DOI: 10.1080/17520363.2025.2471743

Hatice Eyiol, Azmi Eyiol, Ahmet Taha Sahin

引用次数: 0

Implications of Raftlin in different diseases: from molecular biology to diagnostic value. Raftlin在不同疾病中的意义：从分子生物学到诊断价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1080/17520363.2025.2453411

Fugui Lin, Li Yan, Xiumei Yuan, Xingwen Yang, Xiaoyan Yang, Yang Yang, Li Ma, Lianhua Wei, Dehong Li

{"title":"Implications of Raftlin in different diseases: from molecular biology to diagnostic value.","authors":"Fugui Lin, Li Yan, Xiumei Yuan, Xingwen Yang, Xiaoyan Yang, Yang Yang, Li Ma, Lianhua Wei, Dehong Li","doi":"10.1080/17520363.2025.2453411","DOIUrl":"10.1080/17520363.2025.2453411","url":null,"abstract":"Raftlin (raft-linking) protein is an essential component of the lipid raft structure and plays a crucial role in B and T cell signaling pathways. It facilitates B cell receptor (BCR) signaling by promoting calcium mobilization and tyrosine phosphorylation in the cells while colocalizing with BCR on the cell membrane. Interestingly, Raftlin is internalized in lipopolysaccharide-stimulated T cells by colocalization with Toll-like receptor 4 (TLR4), wherein it exerts a similar role as in B cells. The protein also effectuates poly(I:C) internalization into TLR3-positive endosomes in dendritic and epithelial cells through clathrin binding, thereby affecting interferon-β production. In addition, Raftlin controls the vascular endothelial cells and participates in cell growth and proliferation. Recent studies have indicated Raftlin to be a novel biomarker for the diagnosis due to its upregulated expression in malignant diseases. In this integrated study, we present the biological functions of Raftlin and its expression to provide a theoretical basis for the prevention, diagnosis, and treatment of various diseases.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"91-99"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncertainty in the diagnosis and prognosis of adult-onset Still's disease.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-28 DOI: 10.1080/17520363.2025.2459591

Ashok Kumar Pannu

引用次数: 0

Albumin-bilirubin score: a promising predictor of postoperative distant metastasis in patients with colorectal cancer. 白蛋白-胆红素评分：结直肠癌患者术后远处转移的一个有希望的预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1080/17520363.2025.2455928

Xiuying Shi, Shuyi Zhang, Baijun Bao, Hui Cong, Xiaomin Lu, Aijun Shi

{"title":"Albumin-bilirubin score: a promising predictor of postoperative distant metastasis in patients with colorectal cancer.","authors":"Xiuying Shi, Shuyi Zhang, Baijun Bao, Hui Cong, Xiaomin Lu, Aijun Shi","doi":"10.1080/17520363.2025.2455928","DOIUrl":"10.1080/17520363.2025.2455928","url":null,"abstract":"Aim: The objective of this study was to investigate the prognostic significance of the preoperative serum albumin-bilirubin (ALBI) score in patients with colorectal cancer (CRC).Methods: Preoperative ALBI data from 1506 CRC patients were categorized into high-value and low-value groups, and the clinicopathological characteristics of these groups were compared. A Cox proportional hazards regression model was employed to investigate the risk factors associated with distant metastasis. The Kaplan-Meier method and log-rank test were utilized to analyze the relationship between ALBI scores and 5-year distant metastasis-free survival (DMFS).Results: The incidence of distant metastasis in group B (ALBI ≥ -2.4) was significantly higher at 28.81% compared to group A (ALBI < -2.4), which had an incidence of 23.36% (p = 0.018). ALBI score ≥ -2.4 was identified as an independent risk factor for postoperative distant metastasis of CRC (HR = 1.251, 95%CI: 1.021-1.533, p = 0.031). The incidence of 5-year DMFS was significantly lower in the ALBI ≥ -2.4 group compared to that observed in the ALBI < -2.4 group (χ2 = 5.97, p = 0.015, log-rank test).Conclusion: The ALBI score of ≥ -2.4 emerges as an independent risk factor for the occurrence of distant metastases following CRC surgery.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"73-79"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1080/17520363.2025.2455924

X H Chen, L Li, S Y Ma, C Q Ling, J Q Lai, H J Yao, W B Guo, Y Yang, Y Zhang, W J Lin, F Z He

{"title":"Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes.","authors":"X H Chen, L Li, S Y Ma, C Q Ling, J Q Lai, H J Yao, W B Guo, Y Yang, Y Zhang, W J Lin, F Z He","doi":"10.1080/17520363.2025.2455924","DOIUrl":"10.1080/17520363.2025.2455924","url":null,"abstract":"Objective: This study aims to explore the association between arginase 1 (ARG1) genetic variation and susceptibility to type 2 diabetes (T2DM) vascular complications, a primary cause of morbidity and mortality in diabetics.Methods: ARG1, a risk gene for cardiovascular disease, was identified from GEO datasets GSE22255 and GSE58294. The ENCODE database identified four candidate single-nucleotide polymorphism (SNP) loci. Nine hundred ninety-two T2DM patients underwent SNP genotyping, and relevant biochemical markers were tested. Logistic regression analysis calculated the odds ratio (OR) and 95% confidence interval (CI) between ARG1 SNP and diabetic vascular complications.Results: Out of 985 patients, 250 had CHD, with the TTTG group accounting for 64/250. This group showed a significant reduction in CHD risk (non-TTTG factor-adjusted OR = 1.61, 95% CI: 1.14-2.29, p = 0.008). The combination of the TTTG group, age, central obesity, and hypertension better predicted CHD risk (Area under the curve = 0.72, p < 0.001).Conclusions: ARG1 polymorphisms significantly impact vascular complications in T2DM patients, implying that ARG1 genetic variation may be a potential prevention and treatment target.Trial registration: ChiCTR1800015661.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"63-72"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-38 as a potential diagnostic biomarker for heart failure.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-02-13 DOI: 10.1080/17520363.2025.2459595

Hongman Liu, Mingliang Zhang, Wen Gong, Faqiang Tian, Lei Zhang, Jin Zhao, Bing Xiang, Jie Hui

{"title":"Interleukin-38 as a potential diagnostic biomarker for heart failure.","authors":"Hongman Liu, Mingliang Zhang, Wen Gong, Faqiang Tian, Lei Zhang, Jin Zhao, Bing Xiang, Jie Hui","doi":"10.1080/17520363.2025.2459595","DOIUrl":"10.1080/17520363.2025.2459595","url":null,"abstract":"Objective: Interleukin-38 (IL-38) attenuates inflammation, myocardial injury, and ventricular remodeling after myocardial infarction, which potentially reduces the incidence of heart failure (HF). This study aimed to evaluate the diagnostic value of IL-38 for HF.Methods: IL-38 was detected via enzyme-linked immunosorbent assay in the serum samples of 238 hF patients and 30 healthy controls when enrollment.Results: IL-38 was elevated in HF patients compared with controls (p = 0.002). Receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) of IL-38 for predicting HF risk was 0.676 (95% confidence interval = 0.594-0.758). The Youden index of IL-38 for diagnosing HF peaked at 0.329 when the cutoff value of IL-38 was set as 6 ng/mL, with sensitivity and specificity of 0.833 and 0.496, respectively. Before (odds ratio = 1.493, p = 0.002) and after (odds ratio = 1.500, p = 0.007) adjustment of age and gender by multivariable regression analysis, IL-38 was associated with a higher HF risk. Moreover, the combination of IL-38 with age and gender possessed a good value for predicting HF risk (AUC = 0.796, 95% confidence interval = 0.706-0.885).Conclusion: IL-38 is increased in HF patients compared with controls, and its combination with age and gender shows a good value for the diagnosis of HF.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"105-111"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1080/17520363.2025.2459596

Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin

{"title":"The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis.","authors":"Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin","doi":"10.1080/17520363.2025.2459596","DOIUrl":"10.1080/17520363.2025.2459596","url":null,"abstract":"Aim: Ulcerative colitis (UC) is an incurable disease represented by relapse and remission. Noninvasive biomarkers are required to predict disease activation. This study aimed to identify noninvasive biomarkers, such as the c-reactive protein-albumin (CRP/ALB) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), that might forecast disease activation in UC.Methods: This retrospective study included 443 participants: 192 patients with active UC, 166 in remission, and 85 healthy controls. Mayo Endoscopic Subscore was employed to assess endoscopic disease activity. Serum CRP, erythrocyte sedimentation rate (ESR), ALB levels, and complete blood count characteristics were documented. Three ratios of inflammation-related indicators were identified as CRP/ALB, PLR, and NLR.Results: A positive correlation was found between ESR, CRP, neutrophil count, platelet count, levels of CRP/ALB, PLR, NLR, and endoscopic activity. The CRP/ALB ratio demonstrated more efficacy than the NLR and PLR in differentiating the UC patients from the controls (p = 0.007, p = 0.003, respectively) and the active group from the remission group (p < 0.001, p < 0.001, respectively). Regression analysis revealed that the CRP/ALB was significantly able to distinguish active UC from the remission group and the controls (p < 0.001, p < 0.001, respectively).Conclusion: The CRP/ALB ratio could be useful as an independent predictive biomarker for disease activity in UC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"113-119"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1080/17520363.2025.2459590

Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek

{"title":"The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI.","authors":"Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek","doi":"10.1080/17520363.2025.2459590","DOIUrl":"10.1080/17520363.2025.2459590","url":null,"abstract":"Objective: Newly diagnosed AF (NOAF) associated with acute STEMI holds significant relevance in clinical practice. This study seeks to assess the role of the monocyte to HDL-C ratio (MHR) in predicting NOAF in these patients.Methods: Between July 2017 and May 2018, 663 patients who underwent primary PCI for STEMI were retrospectively analyzed. NOAF was identified in 34 patients (5.1%), and this group was compared with those without AF.Results: The NOAF group experienced a longer hospitalization duration and a higher mortality rate (11.8 vs. 4.3%, p = 0.044) compared to the non-AF group. In a multivariable analysis, increased MHR (OR: 1.413, 95% CI: 1.203-1.657, p = 0.005), advanced age, decreased LVEF, Killip class 2-4, diabetes mellitus, hypertension, and left atrial enlargement emerged as independent predictors for the development of NOAF in STEMI. ROC curve analysis revealed that MHR values exceeding 26.54 strongly predict NOAF, achieving sensitivity and specificity above 70% (AUC: 0.768, 95%CI: 0.734-0.801, p < 0.001).Conclusion: The present study revealed that increased MHR robust indicator for NOAF in STEMI patients and can be easily assessed in clinical practice. Incorporating MHR alongside established traditional risk factors may enhance the identification of patients at risk for AF in those with STEMI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"121-128"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0