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Biomarkers in medicine最新文献

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NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients. NEAT1和CHROMR lncRNAs：弥漫大B细胞淋巴瘤（尤其是老年患者）的有望诊断工具。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389036
Ali Rajabi,Ali Saber,Joost Kluiver,Anke van den Berg,Mohammad Ali Hosseinpourfeizi,Reza Safaralizadeh
{"title":"NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients.","authors":"Ali Rajabi,Ali Saber,Joost Kluiver,Anke van den Berg,Mohammad Ali Hosseinpourfeizi,Reza Safaralizadeh","doi":"10.1080/17520363.2024.2389036","DOIUrl":"https://doi.org/10.1080/17520363.2024.2389036","url":null,"abstract":"Background: Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics.Methods & materials: DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels.Results: NEAT1 and CHROMR expressions were significantly increased in DLBCL, and were linked with the age of DLBCL patients (aged >60). NEAT1 and CHROMR overexpression may serve as moderate-to-good diagnostic biomarkers, with NEAT1 and CHROMR exhibiting area under the curve values of 0.781 and 0.831, respectively.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"41 9 1","pages":"685-693"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naples prognostic score as a predictor of mortality in surgical aortic valve replacement. 那不勒斯预后评分作为外科主动脉瓣置换术死亡率的预测指标。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389035
Onur Erdoğan,Tuğba Erdoğan,Cafer Panç,İsmail Gürbak,Mehmet Ertürk
{"title":"Naples prognostic score as a predictor of mortality in surgical aortic valve replacement.","authors":"Onur Erdoğan,Tuğba Erdoğan,Cafer Panç,İsmail Gürbak,Mehmet Ertürk","doi":"10.1080/17520363.2024.2389035","DOIUrl":"https://doi.org/10.1080/17520363.2024.2389035","url":null,"abstract":"Aim: Investigating the impact of nutritional and inflammatory status, assessed by the Naples-Prognostic-Score (NPS), on postoperative mortality in 173 older adults undergoing surgical aortic valve replacement(SAVR) for aortic stenosis(AS).Methods: Retrospective study calculating NPS from neutrophils/lymphocytes, lymphocytes/monocytes, total cholesterol and serum albumin.Results: Mean age was 69.39 ± 6.153 with 45.1% females. The post-operative mortality was 23.7% over a follow-up period of 50 ± 31 months. The 1-month mortality rate is 2.89%. High NPS significantly associated with increased mortality; multivariate logistic regression confirmed its independence (odds-ratio:3.494, 95% confidence-interval:1.555-7.849, p = 0.002). NPS cutoff of 2 showed 73.2% sensitivity, 56.8% specificity and area-under-the-curve of 0.758 for predicting all-cause mortality. Kaplan-Meier analysis supported lower NPS correlating with better survival.Conclusion: NPS independently predicts postoperative mortality in SAVR patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"9 1","pages":"675-683"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns. 与败血症相关的尿胱抑素 C 和尿 NGAL 可预测早产新生儿住院时间的延长。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2377532
Joycilene da Silva Barbosa,Gdayllon Cavalcante Meneses,Luan Rebouças Castelo,Geraldo Bezerra da Silva Júnior,Alice Maria Costa Martins,Elizabeth De Francesco Daher,Tiago Lima Sampaio,Amanda de Oliveira Gomes,Suzzy Maria Carvalho Dantas,Arthur da Silva Rebouças,Paula Roberta de Lima,Nicole Coelho Lopes,Mateus Edson da Silva,Mac Dionys Rodrigues da Costa,Ana Amelia Reis Jereissati,Victoria Queiroz Ramos,Rosângela Pinheiro Gonçalves Machado,Romélia Pinheiro Gonçalves Lemes
{"title":"Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.","authors":"Joycilene da Silva Barbosa,Gdayllon Cavalcante Meneses,Luan Rebouças Castelo,Geraldo Bezerra da Silva Júnior,Alice Maria Costa Martins,Elizabeth De Francesco Daher,Tiago Lima Sampaio,Amanda de Oliveira Gomes,Suzzy Maria Carvalho Dantas,Arthur da Silva Rebouças,Paula Roberta de Lima,Nicole Coelho Lopes,Mateus Edson da Silva,Mac Dionys Rodrigues da Costa,Ana Amelia Reis Jereissati,Victoria Queiroz Ramos,Rosângela Pinheiro Gonçalves Machado,Romélia Pinheiro Gonçalves Lemes","doi":"10.1080/17520363.2024.2377532","DOIUrl":"https://doi.org/10.1080/17520363.2024.2377532","url":null,"abstract":"Aim: To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.Methods: Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.Results: Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; p = 0.01).Conclusion: uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"33 1","pages":"649-658"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic polymorphisms of LMX1B and MLXIP are associated with hip osteoarthritis in the Chinese population. 中国人群中 LMX1B 和 MLXIP 的遗传多态性与髋关节骨关节炎有关。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389030
Chuan Chen,Desheng Kong,Pin Wang,Ming Li,Ranran Gui
{"title":"Genetic polymorphisms of LMX1B and MLXIP are associated with hip osteoarthritis in the Chinese population.","authors":"Chuan Chen,Desheng Kong,Pin Wang,Ming Li,Ranran Gui","doi":"10.1080/17520363.2024.2389030","DOIUrl":"https://doi.org/10.1080/17520363.2024.2389030","url":null,"abstract":"Aims: A large genome-wide analyses of UK Biobank data reported 15 novel loci associated with the susceptibility of hip osteoarthritis (HOA). We aimed to replicate the association of these loci with HOA in the Chinese population.Methods: A total of 13 Single Nucleotide Polymorphisms were genotyped in 892 HOA patients and 1123 healthy controls.Results: The risk allele frequency of rs62578127 and rs11059094 was significantly higher in the patients than in the controls. The mRNA expression of LMX1B (p = 0.01) and MLXIP (p = 0.001) were significantly increased in HOA tissues.Conclusion: We successfully replicated two novel susceptible loci of HOA and further characterized two potential causative genes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"14 1","pages":"695-702"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the baseline blood pH homeostasis at admission and the risk of in-hospital mortality in COVID-19 patients. 洞察 COVID-19 患者入院时的血液 pH 平衡基线和院内死亡风险。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2395800
Mary Pulgar-Sánchez,Kevin Chamorro,Claudio Casella,Santiago J Ballaz
{"title":"Insights into the baseline blood pH homeostasis at admission and the risk of in-hospital mortality in COVID-19 patients.","authors":"Mary Pulgar-Sánchez,Kevin Chamorro,Claudio Casella,Santiago J Ballaz","doi":"10.1080/17520363.2024.2395800","DOIUrl":"https://doi.org/10.1080/17520363.2024.2395800","url":null,"abstract":"Aim: A laboratory finding in critically ill COVID-19 patients is blood academia (pH <7.35). We investigated its cause in connection with the admission baseline blood pH homeostasis.Patients & methods: We retrospectively monitored the baseline blood pH homeostasis of 1215 COVID-19 patients who were admitted with pneumonia using data-driven knowledge. Two categories of patients were identified: non-survivors (107) and survivors (1108).Results: Non-survivors showed greater levels of lactate and lower blood pH, saturation, and partial pressure of oxygen than survivors. A bivariate Spearman's correlation matrix showed that the [HCO3-]/pCO2 and pCO2 of non-survivors exhibited an unmatched connection, but not in the survivor group. When comparing non-survivors to survivors, the dendrograms derived from the bivariate comparison matrix showed differences in gasometry parameters like blood pH, [HCO3-]/pCO2 ratio, anion gap and pO2.Conclusion: The little variations in the gasometry readings between survivors and non-survivors upon admission suggested abnormal changes in the complementary renal and respiratory systems that bring blood pH back to normal. In advanced COVID-19, modest blood acid-base imbalances could become blood acidemia if these compensatory strategies were overused. Data-driven monitoring of acid-base parameters may help predict abnormal blood pH and the advancement of metabolic acidemia before it is too late.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"1 1","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the correlation between homocysteine, red blood cell folate and MTHFRC677T genotypes with female infertility. 探讨同型半胱氨酸、红细胞叶酸和 MTHFRC677T 基因型与女性不孕的相关性。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394386
Xueyun You,Zhaozhen Zhang,Yonghua Xu,Bicheng Yang,Shuhui Huang,Yongyi Zou,Feng Zhao,Chuanxin Feng,Haorui Lao,Huizhen Yuan,Yanqiu Liu,Min Wu
{"title":"Exploring the correlation between homocysteine, red blood cell folate and MTHFRC677T genotypes with female infertility.","authors":"Xueyun You,Zhaozhen Zhang,Yonghua Xu,Bicheng Yang,Shuhui Huang,Yongyi Zou,Feng Zhao,Chuanxin Feng,Haorui Lao,Huizhen Yuan,Yanqiu Liu,Min Wu","doi":"10.1080/17520363.2024.2394386","DOIUrl":"https://doi.org/10.1080/17520363.2024.2394386","url":null,"abstract":"Aim: To investigate the association between serum homocysteine (HCY) levels, red blood cell folate (RCF) levels, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and infertility.Materials & methods: Serum HCY and RCF levels and C677T polymorphism of MTHFR gene were analyzed in 149 infertile patients and 223 women of normal reproductive age with healthy childbirth history.Results: The HCY level of MTHFR C677T TT genotype infertility patients was higher than that of women of normal reproductive age, while the RCF level was not significantly different between the two groups.Conclusion: Serum HCY levels increased in infertility patients, and the MTHFR C677T TT genotype in childbearing-aged women are associated with a higher risk of infertility. The results showed that HCY level and MTHFR C677T genotype were closely related to infertility.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"5 1","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure. 心力衰竭住院期间发现的红细胞分布宽度增加的长期影响。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2395237
Otto Mayer,Jan Bruthans,Josef Jirák,Jan Filipovský
{"title":"The long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure.","authors":"Otto Mayer,Jan Bruthans,Josef Jirák,Jan Filipovský","doi":"10.1080/17520363.2024.2395237","DOIUrl":"https://doi.org/10.1080/17520363.2024.2395237","url":null,"abstract":"Aim: We determined the long-term role of increased RDW (red blood cell distribution width) detected during cardiac decompensation.Methods: We followed 3697 patients [mean age 71.4 years (±SD 10.1), 59.1% males] hospitalized for acute heart failure (HF) and assessed the five-year all-cause mortality risk associated with tertiles of RDW.Results: Patients with RDW in the top tertile showed roughly twofold higher 5-year mortality risk than those in the bottom tertile. The association remained significant not only after adjustments for potential covariates but even if we excluded patients who deceased during the first year of follow-up [HRR 1.76 (95% CIs:1.42-2.18), p < 0.0001].Conclusion: The high degree of anisocytosis represents an independent predictor of poor prognosis in HF patients, even long-term after an acute manifestation.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"6 1","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions. 人类癌前病变和癌症宫颈病变中的 RAP1-GTPase 免疫染色发生了改变。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394384
Paula Cristina de Vasconcelos,Tulio Resende Freitas,Lara Verônica de Araújo Lopes,Larissa Rodrigues Peixoto,Marcelo Pascoal Xavier,Anna Carolina Cançado Figueiredo,Karolina Lopes Dias,Jaqueline Germano de Oliveira,Paulo Guilherme de Oliveira Salles,Annamaria Ravaro Vago,Adriano de Paula Sabino,Maria Gabrielle de Lima Rocha
{"title":"RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions.","authors":"Paula Cristina de Vasconcelos,Tulio Resende Freitas,Lara Verônica de Araújo Lopes,Larissa Rodrigues Peixoto,Marcelo Pascoal Xavier,Anna Carolina Cançado Figueiredo,Karolina Lopes Dias,Jaqueline Germano de Oliveira,Paulo Guilherme de Oliveira Salles,Annamaria Ravaro Vago,Adriano de Paula Sabino,Maria Gabrielle de Lima Rocha","doi":"10.1080/17520363.2024.2394384","DOIUrl":"https://doi.org/10.1080/17520363.2024.2394384","url":null,"abstract":"Aim: This study investigated RAP1 immunostaining variation in different cell types during CC progression.Methods: Paraffin-embedded cervical tissues from 101 patients were categorized into control, pre-neoplastic and neoplastic groups. RAP1 immunolocalization, HPV detection and genotyping were performed. A semiquantitative immunoreactive score was employed to compare labeling intensity, cellular localization, nuclear labeling, percentage and distribution of reactive cells.Results: 73% (72/99) of cervical specimens were HPV+. RAP1 was localized in the nucleus and cytoplasm of all samples. Cytoplasmic RAP1 immunoscore was higher than nuclear score in all CC groups. RAP1 intensity increased with lesion severity. SCC samples exhibited predominantly intense RAP1 immunostaining.Conclusion: RAP1 is an efficient biomarker for detecting invasive CC lesions but has limited utility in distinguishing SCC grades.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"12 1","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial infarction. 确诊为心肌梗死患者的 HbA1c/C 肽水平与短期死亡率之间的关系。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-08-17 Epub Date: 2024-08-05 DOI: 10.1080/17520363.2024.2380248
Sefa Erdi Ömür, Emin Koyun, Gökhan Cabri, Çağri Zorlu
{"title":"The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial infarction.","authors":"Sefa Erdi Ömür, Emin Koyun, Gökhan Cabri, Çağri Zorlu","doi":"10.1080/17520363.2024.2380248","DOIUrl":"10.1080/17520363.2024.2380248","url":null,"abstract":"<p><p><b>Introduction:</b> In this study, we aimed to investigate the effect of HbA1C/C-peptide ratio on short-term mortality (this period is defined as 30 days after diagnosis) in the patients with myocardial infarction.<b>Materials & Methods:</b> Around 3245 patients who were admitted due to ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction underwent primary percutaneous coronary intervention between October 2020 and 2024 were included in this study.<b>Results:</b> In the receiver operating characteristic analysis, the predictive power of the HCR score for mortality in ST-elevation myocardial infarction patients was determined to be 83% sensitivity and 81% specificity. In non-ST-elevation myocardial infarction, this was determined to be 78% sensitivity and 75% specificity.<b>Conclusion:</b> The HbA1C/C-peptide ratio score can predict poor clinical outcomes early, reducing mortality and morbidity in patients with myocardial infarction.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"665-673"},"PeriodicalIF":1.9,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of miR-200 family in non-small cell lung cancer: a meta-analysis miR-200 家族在非小细胞肺癌中的诊断价值：一项荟萃分析
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-16 DOI: 10.2217/bmm-2024-0087
Zhen Ling, Lichang Yang
{"title":"Diagnostic value of miR-200 family in non-small cell lung cancer: a meta-analysis","authors":"Zhen Ling, Lichang Yang","doi":"10.2217/bmm-2024-0087","DOIUrl":"https://doi.org/10.2217/bmm-2024-0087","url":null,"abstract":"<p><b>Aim:</b> To investigate the diagnostic potential of the miR-200 family for early detection in non-small cell lung cancer (NSCLC). <b>Materials &amp; methods:</b> A systematic search was conducted of PubMed, Embase and Web of Science databases to identify studies of the miR-200 family in NSCLC. Sixteen studies meeting the inclusion criteria were included in the analysis with a total of 20 cohorts. <b>Results:</b> The combined sensitivity and specificity reached 73% and 85%, with an area under the curve of 0.83. Notably, miR-200b introduced heterogeneity. Subgroup analysis highlighted miR-200a and miR-141 as more sensitive, while blood-derived miRNAs showed slightly lower accuracy. <b>Conclusion:</b> The miR-200 family, predominantly assessed in blood, exhibits significant diagnostic potential for NSCLC, especially in distinguishing it from benign diseases.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"43 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141061640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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