Biomarkers in medicine最新文献_第3页

Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy. 外泌体PD-L1在癌症治疗中的临床病理和预后意义。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/17520363.2024.2448117

Shunqin Hu, Fengchang Huang, Xiuying Li

{"title":"Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy.","authors":"Shunqin Hu, Fengchang Huang, Xiuying Li","doi":"10.1080/17520363.2024.2448117","DOIUrl":"10.1080/17520363.2024.2448117","url":null,"abstract":"Aim: The exosomal programmed death ligand-1(exoPD-L1) has recently become a topic of interest in the field of oncology. But the prognostic role of exoPD-L1 in cancer patients is inconsistent across previous studies. Therefore, a quantitative meta-analysis was performed to evaluate the prognostic and clinicopathological value of exoPD-L1 in cancer patients.Materials and methods: Twenty eligible studies were included in this study. The relationship between baseline level of exoPD-L1 and clinicopathological features, therapeutic response, overall survival (OS) and progression-free survival (PFS) was evaluated.Results: Pooled analysis indicated that high level of exoPD-L1 was significantly associated with higher tumor stage, positive lymph node metastasis, and advanced TNM stage. Elevated exoPD-L1 was associated with short OS [HR = 1.80 (1.27-2.55), p = 0.001]. In the subgroup analysis, high-level exoPD-L1 was consistently associated with poor OS in sample source, detection method, and lymphoma patients. Moreover, elevated exoPD-L1 was predictive of worse PFS [HR = 1.28 (1.13-4.18), p = 0.000]. In addition, a striking difference between cancer patients and healthy donors was observed in the level of exoPD-L1.Conclusion: exoPD-L1 is an original and effective liquid biomarker for cancer patients. However, large-scale, prospective investigations are still needed to confirm our findings.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 2","pages":"51-57"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer. 18F-FDG PET/CT代谢参数对非小细胞肺癌淋巴结转移的预测价值

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.1080/17520363.2024.2443379

Xiaopeng Yu, Jianlin Wang, Liqun Huang, Long Xie, Yingrui Su

{"title":"Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer.","authors":"Xiaopeng Yu, Jianlin Wang, Liqun Huang, Long Xie, Yingrui Su","doi":"10.1080/17520363.2024.2443379","DOIUrl":"10.1080/17520363.2024.2443379","url":null,"abstract":"Background: Lymph node metastasis is closely associated with the prognosis of patients with non-small cell lung cancer (NSCLC). This study aimed to evaluate the role of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters in mediastinal lymph node metastasis in NSCLC.Methods: One hundred patients with NSCLC who underwent surgery, systematic lymph node dissection, who had undergone 18FFDG PET/CT for initial staging were divided into two groups: lymph node metastasis and non-metastasis. The maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), SUV in the liver (SURliver), mediastinal blood pool (SURblood), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were detected in both groups. Receiver operating characteristic (ROC) curves were used to evaluate the parameters for predicting the diagnostic efficacy.Results: The SUVmax, SUVmean, SURblood, SURliver, MTV, and TLG were higher in the group with lymph node metastasis than in the group without lymph node metastasis. The ROC analysis showed that 18F-FDG PET/CT demonstrated acceptable predictive ability with AUC of 0.964 (95% CI, 0.930-0.998).Conclusions: The relative 18F-FDG PET/CT primary uptake and substitution parameters showed acceptable predictive efficacy for mediastinal lymph node metastasis in patients with NSCLC. Additional, SURblood has potential for clinical application.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"35-41"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi. 中性粒细胞与淋巴细胞比值和MELD评分对HBV-DeCi患者短期生存的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.1080/17520363.2024.2448112

Zhong Han, Liangshuai Qi, Sirui Chen, Jinfei Zhang, Xueliang Guo, Chunying Liang, Weiwei Zheng

{"title":"Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi.","authors":"Zhong Han, Liangshuai Qi, Sirui Chen, Jinfei Zhang, Xueliang Guo, Chunying Liang, Weiwei Zheng","doi":"10.1080/17520363.2024.2448112","DOIUrl":"10.1080/17520363.2024.2448112","url":null,"abstract":"Objective: The prognostic value of neutrophil-to-lymphocyte ratio (NLR) combined with Model for End-Stage Liver Disease (MELD) score was evaluated for hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi).Methods: The 30-day mortality of 166 hBV-DeCi patients was examined. Receiver operating characteristic curve analysis and multivariate regression analysis were used to assess the performance of NLR for prediction of poor outcomes.Results: The 30-day mortality rate was 10.2% (17/166). NLR was significantly lower in survivors than in non-survivors, and could be used for prognosis prediction in HBV-DeCi patients. Area under the curve was higher for NLR combined with MELD score than for each factor alone. (MELD score, AUC:0.864、NLR, AUC:0.781, Combined, AUC:0.920) The Odds ratio of MELD score is lower than NLR.(MELD score:1.447&NLR:1.745).Conclusions: The findings demonstrate that NLR combined with MELD score has a high prognostic value for HBV-DeCi patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"43-49"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of the Naples prognostic score for no-reflow phenomenon after saphenous vein graft stenting. 那不勒斯预后评分对隐静脉支架植入术后无血流现象的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-22 DOI: 10.1080/17520363.2024.2443383

Cemalettin Yılmaz, Ahmet Karaduman, Muhammet Mücahit Tiryaki, Büşra Güvendi Şengör, Tuba Unkun, Barkın Kültürsay, Regayip Zehir

{"title":"Predictive value of the Naples prognostic score for no-reflow phenomenon after saphenous vein graft stenting.","authors":"Cemalettin Yılmaz, Ahmet Karaduman, Muhammet Mücahit Tiryaki, Büşra Güvendi Şengör, Tuba Unkun, Barkın Kültürsay, Regayip Zehir","doi":"10.1080/17520363.2024.2443383","DOIUrl":"10.1080/17520363.2024.2443383","url":null,"abstract":"Background: No-reflow is a critical adverse event associated with percutaneous coronary intervention (PCI), particularly during saphenous vein graft (SVG) procedures. The Naples Prognostic Score (NPS) reflects inflammatory status, but its relationship with no-reflow remains unclear. Therefore, we aimed to evaluate the relationship between NPS and no-reflow occurrence following SVG PCI.Methods: We retrospectively analyzed 286 patients who underwent SVG PCI from January 2020 to January 2024, with a median age of 65 years and 85.7% male. Participants were categorized into low NPS (0-2, 48.6%) and high NPS (3-4, 51.4%) groups. Two nested models were developed by adding NPS (continuous and categorical, respectively) to the base model.Results: Higher no-reflow rates were noted in the high-NPS group (48.5% vs. 9.5%, p < 0.05). Multivariable regression revealed that a higher NPS significantly increased no-reflow risk, with odds ratios of 5.966 (95% CI: 3.066-11.611) for continuous NPS and 10.110 (95% CI: 3.194-32.002) for categorical NPS. Adding NPS to the base model significantly improved predictive performance (likelihood-ratio test p < 0.001). Model 1 demonstrated the best performance (X2 : 84.857, R2 : 0.468) and discriminative ability (AUC: 0.888).Conclusion: Our findings suggest that NPS is a strong predictor of no-reflow following SVG PCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"13-22"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of D-dimer as a diagnostic and prognostic biomarker for acute pericarditis. 探讨d -二聚体作为急性心包炎诊断和预后生物标志物的潜力。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-28 DOI: 10.1080/17520363.2024.2448021

George Lazaros, Emilia Lazarou, Charalambos Vlachopoulos, Costas Tsioufis

引用次数: 0

Triglyceride-glucose index as a biomarker to differentiate stroke etiologic subtypes: a hospital-based cross-sectional study. 甘油三酯-葡萄糖指数作为区分脑卒中病因亚型的生物标志物：一项基于医院的横断面研究

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1080/17520363.2024.2443382

Nizar Daoussi, Imen Zemni, Narjes Gouta, Yasmine Saad, Rihab Ben Dhia, Mariem Mhiri, Asma Belghith-Sriha, Mahbouba Frih-Ayed

{"title":"Triglyceride-glucose index as a biomarker to differentiate stroke etiologic subtypes: a hospital-based cross-sectional study.","authors":"Nizar Daoussi, Imen Zemni, Narjes Gouta, Yasmine Saad, Rihab Ben Dhia, Mariem Mhiri, Asma Belghith-Sriha, Mahbouba Frih-Ayed","doi":"10.1080/17520363.2024.2443382","DOIUrl":"10.1080/17520363.2024.2443382","url":null,"abstract":"Background: Accurate distinction between stroke etiologic subtypes is critical for physicians to provide tailored treatment. The triglyceride-glucose (TyG) index, a marker of insulin resistance, has been associated with stroke risk but its role in distinguishing stroke etiologic subtypes remains unclear. We aimed to assess the TyG index's ability to differentiate cardioembolic (CE) from non-cardioembolic (NCE) strokes.Methods: We studied 320 consecutive stroke patients in a cross-sectional analysis. Binary logistic regression was performed to analyze the association between the TyG index and the studied stroke subtypes. Receiver operating characteristic (ROC) curve analysis identified the optimal TyG index cutoff for CE vs. NCE differentiation.Results: TyG index correlated independently with NCE subtype (OR = 2.38; 95% CI = 1.52-3.73; p < 0.001). Logistic regression revealed increasing NCE stroke risk with higher TyG index quartiles. The ROC curve yielded an AUC of 0.636 (95% CI = 0.565-0.707; p < 0.001), with a cutoff of 8.8 (sensitivity = 68.8%, specificity = 57%).Conclusion: The TyG index can be a useful biomarker in the differentiation between CE and NCE strokes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 1","pages":"23-29"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Torquetenovirus in bronchoalveolar lavage fluid for early detection of pulmonary infections in immunocompromised hosts. 支气管肺泡灌洗液中torquetenvirus对免疫功能低下宿主肺部感染的早期检测。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1080/17520363.2025.2453416

Ashok Kumar Pannu

引用次数: 0

Hematological markers as prognostic indicators in multiple sclerosis progression. 血液学指标作为多发性硬化进展的预后指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1080/17520363.2024.2441106

Maryam Poursadeghfard, Samin Shiati, Mohammad Saied Salehi, Aryan Khani, Soheil Vafaeian, Mahnaz Bayat, Etrat Hooshmandi

引用次数: 0

TMB is associated with the prognosis of egfr-mutated non-small cell lung cancer in Xuanwei, China. 在宣威，TMB与egfr突变的非小细胞肺癌的预后相关。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1080/17520363.2024.2432306

Han Wang, Junrui Ma, Jiagui Lu, Yang Wang, Binli Zhang, Hushan Zhang, Hao Peng

引用次数: 0

Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis. 严重主动脉瓣狭窄的 TAVI 患者中 N-乙酰葡糖苷酶和肾损伤分子-1 的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1080/17520363.2024.2429366

Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer

{"title":"Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis.","authors":"Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer","doi":"10.1080/17520363.2024.2429366","DOIUrl":"10.1080/17520363.2024.2429366","url":null,"abstract":"Aim: Cardiorenal syndrome (CRS) is common in severe aortic stenosis (AS). Previous studies revealed N-Acetylglucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for CRS. The study aimed to investigate the prognostic capability of NAG, KIM-1, NT-proBNP in severe AS before TAVI.Materials & methods: Plasma and urine samples were collected from 151 participants before TAVI. Long-term follow-up (median follow-up time 31 months) was conducted to assess all-cause mortality and a composite endpoint of mortality and congestive heart failure.Results: NT-proBNP was significantly elevated in classical low-flow, low-gradient AS compared to other severe AS phenotypes (p < 0.01), unlike NAG and KIM-1 (each p = n.s.). During follow-up, 40 patients (26.5%) died, and 58 patients (38.4%) reached the composite endpoint. Elevated baseline levels of NAG and KIM-1 were associated with increased risk of all-cause mortality in Kaplan-Meier analysis, like NT-proBNP (each p<0.05). NAG and STS-Score were revealed as significant predictors for all-cause mortality in multivariable COX-regression analysis (each p<0.05), unlike NT-proBNP, KIM-1, eGFR, and clinical parameters (each p=n.s.).Conclusion: Baseline NAG and, to a lesser degree, KIM-1 and NT-proBNP provide significant predictive value for all-cause mortality in patients with severe AS before TAVI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1075-1085"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0