Biomarkers in medicine最新文献_第3页

Peripheral biomarkers in rheumatoid arthritis-associated interstitial lung disease: a review of roles and candidates. 外周生物标志物在类风湿关节炎相关间质性肺疾病中的作用和候选研究综述

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-07 DOI: 10.1080/17520363.2026.2697708

Brent A Luedders, Scott M Matson, Bryant R England

引用次数: 0

Multimodal biomarker profiling in varicocele predicts surgical recovery. 精索静脉曲张的多模式生物标志物分析预测手术恢复。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI: 10.1080/17520363.2026.2686307

Lei Zheng, Zhiming Wen, Letian Wei, Tao Jiang

{"title":"Multimodal biomarker profiling in varicocele predicts surgical recovery.","authors":"Lei Zheng, Zhiming Wen, Letian Wei, Tao Jiang","doi":"10.1080/17520363.2026.2686307","DOIUrl":"10.1080/17520363.2026.2686307","url":null,"abstract":"Aims: Varicocele (VC) remains a leading correctable cause of male infertility, yet standardized multimodal biomarkers are lacking for clinical stratification and outcome prediction.Patients and methods: This prospective observational study enrolled 131 primary VC patients and 20 healthy controls, evaluating semen parameters, sperm DNA fragmentation index (DFI), testicular shear wave elastography (SWE), hormonal profiles, and inflammatory/metabolic markers.Results: VC patients showed reduced sperm progressive motility (sperm PM) (p < 0.001), elevated DFI (p = 0.002), increased abnormal sperm morphology (p < 0.001); smaller left (p = 0.002) and right (p = 0.029) testis, volume difference (p = 0.030); bilateral testicular stiffness (left p < 0.001, right p < 0.001); higher homocysteine (p = 0.001); and a lower T/E2 ratio (p = 0.030). DFI correlated negatively with sperm PM (r = -0.367, p < 0.001). Postoperative improvements were observed in sperm PM (p < 0.001), sperm morphology (p < 0.001), DFI (p < 0.001), left testicular elasticity (p < 0.001), right testicular elasticity (p < 0.001), homocysteine (p = 0.001), testosterone (p = 0.011), and the T/E2 ratio (p = 0.011). Preoperative DFI (OR =1.045), abnormal sperm morphology rate (OR =1.604), and sperm PM (OR =0.951) independently predicted complete semen parameter recovery at 3 months (AUC = 0.863, sensitivity 67.9%, specificity 89.5%).Conclusion: An integrated multimodal framework incorporating imaging, molecular, and functional biomarkers facilitates prognostic stratification and personalized management of varicocele-associated infertility.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"583-594"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial sST2 dynamics after transcatheter tricuspid valve intervention: a candidate biomarker of biological response. 经导管三尖瓣干预后sST2序列动态：生物反应的候选生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-03 DOI: 10.1080/17520363.2026.2697762

Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter

{"title":"Serial sST2 dynamics after transcatheter tricuspid valve intervention: a candidate biomarker of biological response.","authors":"Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter","doi":"10.1080/17520363.2026.2697762","DOIUrl":"10.1080/17520363.2026.2697762","url":null,"abstract":"Aims: Patients undergoing transcatheter tricuspid valve intervention (TTVI) frequently present with advanced right-sided heart failure and multiorgan dysfunction, limiting the interpretability of conventional biomarkers such as natriuretic peptides. Soluble suppression of tumorigenicity 2 (sST2), a marker of myocardial strain, inflammation, and fibrosis, may provide complementary insight into biological response following intervention.Patients & methods: In this prospective single-center cohort study, 135 patients undergoing TTVI were included. Plasma concentrations of sST2 were measured at baseline, discharge, 3 months, and 12 months. Longitudinal changes were analyzed using non-parametric repeated measures testing and compared with established biomarkers, including GDF-15, suPAR, H-FABP, NT-proANP and supplementary NT-proBNP analyses.Results: sST2 demonstrated a distinct biphasic trajectory, with an early increase at discharge followed by a significant decline at 3 and 12 months below baseline levels (overall p < 0.001). This pattern remained consistent in sensitivity analyses. In contrast, GDF-15, suPAR, H-FABP, NT-proANP, and supplementary NT-proBNP analyses showed heterogeneous longitudinal profiles without the sustained treatment-related trajectory observed for sST2.Conclusions: In patients undergoing TTVI, sST2 exhibits a characteristic longitudinal profile reflecting biological response to intervention. These findings identify sST2 as a candidate dynamic biomarker and support a framework distinguishing prognostic baseline-risk biomarkers from dynamic treatment-response biomarkers.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"613-620"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory burden index and prognostic outcomes in gastrointestinal cancer: a meta-analysis. 胃肠道肿瘤的炎症负担指数和预后：一项荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-06 DOI: 10.1080/17520363.2026.2712925

Jia-Run Zhang, Rong Qin, Xi Zhang, Xin-Rui Hu

{"title":"Inflammatory burden index and prognostic outcomes in gastrointestinal cancer: a meta-analysis.","authors":"Jia-Run Zhang, Rong Qin, Xi Zhang, Xin-Rui Hu","doi":"10.1080/17520363.2026.2712925","DOIUrl":"10.1080/17520363.2026.2712925","url":null,"abstract":"Background: The Inflammatory Burden Index (IBI) has been identified as a significant prognostic factor in various gastrointestinal (GI) malignancies. However, despite extensive research, its prognostic value remains inconsistent. To clarify this association, we conducted a systematic meta-analysis following rigorous methodological standards.Methods: A comprehensive literature search was performed across PubMed, Web of Science, Embase, Scopus, and Cochrane databases. Ultimately, nine studies were included, covering multiple gastrointestinal cancer subtypes.Results: Our analysis demonstrated that an elevated IBI was significantly associated with poorer overall survival (OS) (HR = 2.14, 95% CI: 1.38-3.31, p = 0.001), disease-free survival (DFS) (HR = 1.75, 95% CI: 1.35-2.26, p < 0.001), and recurrence-free survival (RFS) (HR = 2.15, 95% CI: 1.59-2.92, p < 0.001). Furthermore, IBI levels were significantly correlated with several key clinicopathological factors including age, tumor size, lymph node metastases, lymph-vascular invasion, and neoadjuvant chemotherapy.Conclusion: This meta-analysis suggests that elevated IBI might be a robust predictor for poor survival in GI cancer patients and correlates closely with advanced disease features including larger tumor size, lymph node metastases, and lymph-vascular invasion. These findings underscore IBI as a clinically relevant prognostic biomarker for GI malignancies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"715-722"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness. 甲状腺体积作为PCOS女性早期动脉粥样硬化的标志：与颈动脉内膜-中膜厚度的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-02-16 DOI: 10.1080/17520363.2026.2631622

Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç

{"title":"Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness.","authors":"Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç","doi":"10.1080/17520363.2026.2631622","DOIUrl":"10.1080/17520363.2026.2631622","url":null,"abstract":"Aim: This study aimed to evaluate the determinants of thyroid volume (TV) in euthyroid women with polycystic ovary syndrome (PCOS) and to assess the association between TV and cardiovascular risk, with a particular focus on carotid intima - media thickness (CIMT).Methods: This cross-sectional study included 100 participants (46 women with PCOS and 54 age-matched healthy controls). Only euthyroid participants were enrolled. TV was measured by ultrasonography, and CIMT was evaluated as a marker of early atherosclerosis. Biochemical markers were recorded. Multiple regression and receiver operating characteristic (ROC) analyses were performed.Results: Women with PCOS had significantly higher TV compared to controls [13.4 ml (IQR: 9.8-17.4) vs. 11.3 ml (IQR: 9.6-12.9), p = 0.041]. TV was positively correlated with BMI (r = 0.485, p < 0.001), waist circumference (r = 0.419, p = 0.004), and HOMA-IR (r = 0.406, p = 0.005). CIMT was independently predicted by total testosterone (β = 0.296, p = 0.040), LH/FSH ratio (β = -0.398, p = 0.005) and TV (β = 0.306, p = 0.036). ROC analysis showed that TV moderately predicted elevated CIMT (AUC = 0.68; optimal cutoff =14.5 mL).Discussion: TV was independently associated with CIMT in euthyroid women with PCOS, suggesting that thyroid morphology may serve as a complementary, noninvasive marker of early atherosclerotic changes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"557-567"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification and early diagnostic markers of Primary hepatic carcinoma: a comprehensive review. 原发性肝癌的分类及早期诊断指标综述。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-08 DOI: 10.1080/17520363.2026.2697759

Xinyao Liu, Lin Gong, Weiran Kong, Jie Kong, Yang Zhang, Chuantao Yuan, Shuai Chen

引用次数: 0

Predictive accuracy of cytokine pattern with lymphocyte count in infections after chemotherapies for lymphoma. 细胞因子模式与淋巴细胞计数在淋巴瘤化疗后感染中的预测准确性。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-05-22 DOI: 10.1080/17520363.2026.2654370

Lu Zhang, Dan Zhou, Ji Zhou, Wenqun Yang

{"title":"Predictive accuracy of cytokine pattern with lymphocyte count in infections after chemotherapies for lymphoma.","authors":"Lu Zhang, Dan Zhou, Ji Zhou, Wenqun Yang","doi":"10.1080/17520363.2026.2654370","DOIUrl":"10.1080/17520363.2026.2654370","url":null,"abstract":"Aims: To evaluate whether cytokine profiles combined with lymphocyte count could predict infection risk in lymphoma patients undergoing chemotherapy.Patients & methods: This retrospective study included 110 patients with pathologically confirmed lymphoma treated at Xiangtan Central Hospital between January 2022 and December 2023. Peripheral blood samples were collected before chemotherapy to determine lymphocyte count and serum cytokine levels (IFN-γ, TNF-α, IL-6, IL-8, IL-10) using ELISA. Statistical analyses included ROC curve and Kaplan-Meier survival analysis to assess predictive accuracy and treatment outcomes.Results: Sixty-five patients (59.1%) developed infections, including bacterial, fungal, and viral types. Infected patients exhibited significantly lower lymphocyte counts and decreased cytokine levels. A combination of ≥3 decreased cytokines with low lymphocyte count provided stronger predictive power for infection than single indicators.Conclusion: Reduced cytokine levels together with lymphopenia are strong predictors of infection in lymphoma patients receiving chemotherapy. Immune monitoring of cytokine-lymphocyte patterns may facilitate early identification of high-risk individuals and improve infection prevention and treatment strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"697-703"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coagulation factor levels as prognostic biomarkers: differential profiles in pulmonary versus extrapulmonary sepsis-induced ARDS. 凝血因子水平作为预后生物标志物：肺与肺外败血症诱导的ARDS的差异概况

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI: 10.1080/17520363.2026.2712931

Xiao Lv, Yanfen Zhong, Jianguang Pan, Tao Lin

{"title":"Coagulation factor levels as prognostic biomarkers: differential profiles in pulmonary versus extrapulmonary sepsis-induced ARDS.","authors":"Xiao Lv, Yanfen Zhong, Jianguang Pan, Tao Lin","doi":"10.1080/17520363.2026.2712931","DOIUrl":"10.1080/17520363.2026.2712931","url":null,"abstract":"Objective: To compare the coagulation factor levels in acute respiratory distress syndrome caused by pulmonary infection (ARDSp) and ARDS caused by extrapulmonary sepsis (ARDSexp) patients.Methods: This study included 112 ARDSp and 88 ARDSexp patients. Coagulation factor levels were compared within 24 hours after the diagnosis of ARDS.Results: In the ARDSexp group, prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly prolonged, fibrinogen (FIB) levels were significantly decreased, and D-dimer (D-D) levels were significantly increased. Coagulation factors V and VII levels were significantly lower, while factor VIII levels and the degree of thrombocytopenia were substantially higher in the ARDSexp group, in contrast to the ARDSp group. In terms of prognosis, the ARDSexp group had longer mechanical ventilation duration and ICU stay duration, and higher 28-d and 90-d mortality (all p < 0.05). D-D > 7 mg/L, coagulation factor V < 70%, elevated sequential organ failure assessment (SOFA) score, and antithrombin III <60% were independent predictors of 28-d mortality.Conclusion: This study demonstrates that there are visible coagulation phenotypic distinctions between ARDSp patients and ARDSexp patients. Coagulation factor levels can serve as biomarkers for prognostic assessment and provide a theoretical basis for the development of individualized anticoagulation strategies in clinical practice.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"685-696"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum NLR, PLR and MNV characteristics as predictors of anti-VEGF plus glucocorticoid efficacy in nAMD. 血清NLR、PLR和MNV特征作为nAMD患者抗vegf和糖皮质激素疗效的预测因子。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-16 DOI: 10.1080/17520363.2026.2704571

Fangxiu Yuan, Jiaojiao Tu, Xiutao Liu, Ling Wang, Wei Zhou, Yu Jin

{"title":"Serum NLR, PLR and MNV characteristics as predictors of anti-VEGF plus glucocorticoid efficacy in nAMD.","authors":"Fangxiu Yuan, Jiaojiao Tu, Xiutao Liu, Ling Wang, Wei Zhou, Yu Jin","doi":"10.1080/17520363.2026.2704571","DOIUrl":"10.1080/17520363.2026.2704571","url":null,"abstract":"Aim: To evaluate the combined predictive value of serum neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and macular neovascularization (MNV) characteristics for treatment efficacy in neovascular age-related macular degeneration (nAMD) patients receiving anti-VEGF plus glucocorticoid therapy.Patients and methods: This retrospective study included 145 patients (153 eyes) with nAMD receiving conbercept combined with dexamethasone implant. Patients were categorized as Inactive (n = 89) or Active (n = 64) based on post-treatment MNV activity. Baseline NLR, PLR, and MNV morphology were assessed. Multivariate logistic regression identified independent predictors, and ROC analyses evaluated predictive value.Results: Patients with persistent MNV activity showed significantly higher baseline NLR, PLR, MNV area, and fractal dimension (all p < 0.001). Multivariate analysis identified baseline visual acuity, MNV type, fluid volumes, MNV morphological parameters, and inflammatory markers as independent predictors. The combined model incorporating inflammatory markers and MNV characteristics demonstrated superior performance (AUC = 0.92, 95% CI: 0.87-0.96) with 79.69% sensitivity and 91.01% specificity.Conclusion: Combining serum inflammatory markers with MNV morphological characteristics enhanced predictive value for treatment response in nAMD patients receiving combination therapy. This integrated approach may facilitate personalized treatment strategies in nAMD management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"627-637"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The biomarker compass: a revolution driving precision medicine. 生物标记指南针：一场推动精准医疗的革命。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-20 DOI: 10.1080/17520363.2026.2705371

Scott A Waldman, Andre Terzic

引用次数: 0