Biomarkers in medicine最新文献_第3页

Dietary glycemic index/glycemic load and knee osteoarthritis: associations with inflammation and oxidative stress. 膳食血糖指数/血糖负荷与膝关节骨关节炎：与炎症和氧化应激的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.1080/17520363.2026.2692040

Farshad Amirkhizi, Filiz Mercantepe, Soudabeh Hamedi-Shahraki, Aleksandra Klisic

{"title":"Dietary glycemic index/glycemic load and knee osteoarthritis: associations with inflammation and oxidative stress.","authors":"Farshad Amirkhizi, Filiz Mercantepe, Soudabeh Hamedi-Shahraki, Aleksandra Klisic","doi":"10.1080/17520363.2026.2692040","DOIUrl":"10.1080/17520363.2026.2692040","url":null,"abstract":"Aims: Although dietary glycemic index (GI) and glycemic load (GL) are known to affect inflammation and oxidative balance, their roles in OA are unclear. This study aims to investigate the relationship between dietary GI and GL with inflammation, oxidative stress, and clinical symptoms in patients with knee osteoarthritis (KOA).Patients and methods: In a cross-sectional study, 160 patients diagnosed with KOA were included. Dietary intake was assessed using a validated food frequency questionnaire, and daily GI and GL values were calculated. Clinical symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Results: Higher dietary GI and GL were significantly associated with increased serum levels of malondialdehyde (MDA), total oxidant status (TOS), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP), as well as with decreased total antioxidant capacity (TAC). Dietary GI and GL were positively correlated with the total WOMAC score, as well as with the WOMAC physical activity and stiffness.Conclusion: High dietary GI and GL may be associated with oxidative stress and inflammatory responses, and may worsen clinical symptoms in KOA patients. Nutritional strategies emphasizing low-GI/GL diets may contribute to better symptom control and disease management in KOA.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"483-493"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin resistance‑associated adipokine and oxidative stress profiles in women with polycystic ovary syndrome. 多囊卵巢综合征女性胰岛素抵抗相关脂肪因子和氧化应激谱

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-08 DOI: 10.1080/17520363.2026.2685081

Hiba Muwafaq Saleem, Hussein Riyadh Abdul Kareem Al-Hetty, Hanan Yousif Rasheed, Ruaa Abdulazez Mohammed

{"title":"Insulin resistance‑associated adipokine and oxidative stress profiles in women with polycystic ovary syndrome.","authors":"Hiba Muwafaq Saleem, Hussein Riyadh Abdul Kareem Al-Hetty, Hanan Yousif Rasheed, Ruaa Abdulazez Mohammed","doi":"10.1080/17520363.2026.2685081","DOIUrl":"10.1080/17520363.2026.2685081","url":null,"abstract":"Background: Although polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder among reproductive-aged women, the integrated role of adipokines in linking metabolic and hormonal dysfunction remains incompletely understood.Objective: The study aims to evaluate the associations between lipid profile alterations, selected adipokines (resistin, galectin-3, and apelin), oxidative stress markers, and the insulin resistance index (HOMA-IR) in women with PCOS compared to controls.Methods: This case-control study included 85 women with PCOS and 55 age-matched controls. Anthropometric and clinical data were collected. Levels of lipid profiles, adipokines, oxidative stress markers, and HOMA-IR were measured. Group comparisons and correlation analyses were performed.Results: Women with PCOS demonstrated elevated levels of resistin, galectin-3, and apelin compared to the controls, with respective measurements of 3.55 ± 0.52 vs 1.07 ± 0.34, 10.01 ± 1.76 vs 3.49 ± 1.03, and 289.23 ± 20.08 vs 191.31 ± 31.30), respectively. MDA exhibited a significant increase, whereas TAC was significantly reduced in the PCOS group. HOMA-IR showed significant positive associations with lipid profiles, adipokines, and levels of MDA, and an inverse correlation with HDL and TAC.Conclusion: The findings support the concept that altered adipokine levels and oxidative stress indices may reflect underlying metabolic dysfunction in women with PCOS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"495-502"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation. CALLY指数对经导管主动脉瓣置入术患者的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.1080/17520363.2026.2692041

Serkan Aslan, Ali Rıza Demir, Gökhan Demirci, Emre Aydın, Merve Yükselen Aydın, Begüm Uygur, Hicaz Zencirkiran Ağuş, Arda Güler, Serkan Kahraman, Gamze Babür Güler, Mehmet Ertürk

{"title":"Prognostic value of the CALLY index in patients undergoing transcatheter aortic valve implantation.","authors":"Serkan Aslan, Ali Rıza Demir, Gökhan Demirci, Emre Aydın, Merve Yükselen Aydın, Begüm Uygur, Hicaz Zencirkiran Ağuş, Arda Güler, Serkan Kahraman, Gamze Babür Güler, Mehmet Ertürk","doi":"10.1080/17520363.2026.2692041","DOIUrl":"10.1080/17520363.2026.2692041","url":null,"abstract":"Aims: The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite biomarker reflecting inflammation, nutritional status, and immune response. This study evaluated the association of the CALLY index with all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI).Methods: In this retrospective study, 733 consecutive TAVI patients were classified as Low-CALLY (≤0.95) or High-CALLY (>0.95) using an ROC-derived cutoff. The primary endpoint was all-cause mortality during follow-up. Predictors of mortality were assessed using Cox proportional hazards regression, while discriminative performance and survival were evaluated by ROC and Kaplan-Meier analyses.Results: Mortality was higher in the Low-CALLY group than in the High-CALLY group (57.1% vs. 19.3%; p < 0.001). The CALLY index showed moderate discrimination for mortality (AUC 0.719; 95% CI 0.681-0.757; p < 0.001). In multivariable Cox regression, Low CALLY remained independently associated with mortality in the clinical model (HR 3.31; 95% CI 2.49-4.39), STS-PROM-adjusted model (HR 3.16; 95% CI 2.37-4.22), and EuroSCORE II-adjusted model (HR 3.72; 95% CI 2.84-4.88) (all p < 0.001). Kaplan-Meier analysis showed lower survival in the Low-CALLY group (log-rank p < 0.001).Conclusion: The CALLY index was independently associated with mortality after TAVI and may complement established risk scores in pre-procedural risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"519-530"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of blood urea nitrogen-creatinine ratio for rehospitalization and outcomes in myocardial infarction: a four-year retrospective cohort analysis. 血尿素氮-肌酐比值对再住院和心肌梗死预后的预测价值：一项四年回顾性队列分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-07-03 DOI: 10.1080/17520363.2026.2697755

Atiyeh Ebrahimi, Arsalan Salari, Bahare Gholami-Chaboki, Amirhossein Borghei, Seyedeh Fatemeh Mirrazeghi, Seyed Mehdi Mousavi, Yasaman Borghei

{"title":"Prognostic value of blood urea nitrogen-creatinine ratio for rehospitalization and outcomes in myocardial infarction: a four-year retrospective cohort analysis.","authors":"Atiyeh Ebrahimi, Arsalan Salari, Bahare Gholami-Chaboki, Amirhossein Borghei, Seyedeh Fatemeh Mirrazeghi, Seyed Mehdi Mousavi, Yasaman Borghei","doi":"10.1080/17520363.2026.2697755","DOIUrl":"10.1080/17520363.2026.2697755","url":null,"abstract":"Background: Risk stratification in acute myocardial infarction (AMI) remains a critical challenge in clinical practice. Traditional prognostic markers often require complex or costly assessments, underscoring the need for simple, accessible indicators. This study, conducted with the aim of evaluating the relationship between the blood urea nitrogen (BUN) and creatinine (Cr) ratio and rehospitalization following AMI.Methods: This retrospective cohort study, conducted at a single center, patients diagnosed with AMI. BUN and Cr levels at the time of initial admission were collected to calculate the BUN/Cr ratio, which was categorized into two groups: ≤16.23 and >16.23. Statistical analyses were carried out using IBM SPSS software (version 22).Results: Among 1147 AMI patients, 53% had BUN/Cr ≤16.23 and 42.1% >16.23. Over four years, rehospitalization rates were slightly higher in the high BUN/Cr group but not statistically significant (p > 0.05). Primary outcomes differed significantly, with mortality notably higher in patients with elevated BUN/Cr ratios (3.7% vs. 1.1%) (p < 0.05).Conclusion: While rehospitalization rates over a four‑year period were slightly higher among those with elevated ratios, the difference was not statistically significant. However, patients with a BUN/Cr ratio >16.23 demonstrated markedly increased rates of major adverse cardiac events (MACE) compared to those with lower ratios.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"503-509"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Septin9 gene methylation in plasma for gastric cancer detection: a systematic review and meta-analysis. 血浆Septin9基因甲基化检测胃癌：系统综述和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-12 DOI: 10.1080/17520363.2026.2685066

Yiming Wang, Yuan Wang, Jiaqi Kang, Shan He, Ping Zhang

{"title":"Septin9 gene methylation in plasma for gastric cancer detection: a systematic review and meta-analysis.","authors":"Yiming Wang, Yuan Wang, Jiaqi Kang, Shan He, Ping Zhang","doi":"10.1080/17520363.2026.2685066","DOIUrl":"10.1080/17520363.2026.2685066","url":null,"abstract":"Objective: To evaluate the plasma-based methylated Septin9 (mSEPT9) diagnostic accuracy for gastric cancer (GC) and analyze its performance across different subgroups.Methods: Through comprehensive computer searching, we systematically collected clinical trials on the diagnostic efficacy of plasma mSEPT9 in GC. The search scope covered PubMed, Web of Science, the Cochrane Library, Embase, CNKI, WanFang Data and VIP databases from their establishments to 31 August 2025. Study quality was rigorously assessed with the assistance of Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Meta-analysis via Stata 17.0 and Meta-Disc 1.4 was performed.Results: This study included 9 articles containing 10 studies, encompassing 3,120 participants. Meta-analysis revealed a pooled sensitivity of 0.40 (95%CI: 0.34-0.47), specificity of 0.94 (95%CI: 0.91-0.96), diagnostic odds ratio of 11.10 (95%CI: 6.42-19.18), area under the curve of 0.78 (95%CI: 0.74-0.82). Meta-regression identified sample size and positive criteria algorithm as potential contributors to heterogeneity in sensitivity, although the associations were only of borderline statistical significance. Other covariables were not significantly associated with heterogeneity.Conclusion: Plasma mSEPT9 demonstrated high specificity and relatively low sensitivity in GC. The assay may be unsuitable for general population screening but showed promise as an adjunctive marker in high-risk patients. Heterogeneity and geographical concentration may influence the assessment of mSEPT9.Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD420251140125.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"531-542"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between serum neopterin levels and disease activity in patients with spondyloarthropathy. 脊柱关节病患者血清新蝶呤水平与疾病活动度的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-21 DOI: 10.1080/17520363.2026.2686306

Ayza Kılıç, Rezan Koçak Ulucaköy, Zakir Osmanov, İdil Melis Çobanoğlu, Cemalettin Aybay, Feride Nur Göğüş

{"title":"The relationship between serum neopterin levels and disease activity in patients with spondyloarthropathy.","authors":"Ayza Kılıç, Rezan Koçak Ulucaköy, Zakir Osmanov, İdil Melis Çobanoğlu, Cemalettin Aybay, Feride Nur Göğüş","doi":"10.1080/17520363.2026.2686306","DOIUrl":"10.1080/17520363.2026.2686306","url":null,"abstract":"Objective: Biomarkers that accurately reflect disease activity and inflammatory burden are needed, particularly in the early stages of spondyloarthropathy (SpA). This study aimed to evaluate the association between serum neopterin levels and disease activity indices in patients with SpA.Methods: This cross-sectional study included 84 participants based on a priori sample size estimation: 21 patients with axial SpA (axSpA), 21 with peripheral SpA (pSpA), 21 with active rheumatoid arthritis (RA) and 21 healthy controls (HC). Disease activity in SpA was assessed using the Axial Spondyloarthritis Disease Activity Score (ASDAS) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). A disease activity was assessed using the Disease Activity Score in 28 Joints (DAS28). Serum neopterin levels were measured by Enzyme-Linked Immunosorbent Assay.Results: Serum neopterin levels differed significantly among the groups (post-hoc, p = 0.007), with higher levels observed in patients with active RA than in those with axSpA, and no significant associations were found between neopterin levels and disease activity indices in either axial or peripheral SpA.Conclusion: In the present study cohort, no significant association was observed between serum neopterin levels and disease activity in patients with axial or peripheral SpA.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"511-518"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent prognostic performance of inflammatory biomarkers after AMI: results from the INFINITY study. AMI后炎症生物标志物的时间依赖性预后表现：INFINITY研究的结果。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-07-05 DOI: 10.1080/17520363.2026.2692043

A Mitsis, K Tsiaktani, S K Tasoulis, J Lakoumentas, G Karmioti, M Kyriakou, S Sokratous, M Drakomathioulakis, C Eftychiou, S Tzikas, N P E Kadoglou, G Kassimis

{"title":"Time-dependent prognostic performance of inflammatory biomarkers after AMI: results from the INFINITY study.","authors":"A Mitsis, K Tsiaktani, S K Tasoulis, J Lakoumentas, G Karmioti, M Kyriakou, S Sokratous, M Drakomathioulakis, C Eftychiou, S Tzikas, N P E Kadoglou, G Kassimis","doi":"10.1080/17520363.2026.2692043","DOIUrl":"10.1080/17520363.2026.2692043","url":null,"abstract":"Background: Inflammatory biomarkers derived from routine blood counts reflect immune activation in acute myocardial infarction (AMI). However, their temporal prognostic relevance after AMI remains uncertain.Methods: This prospective sub-study of the INFINITY trial (NCT06065514) included 100 consecutive patients with AMI. Five admission-derived inflammatory biomarkers were evaluated: systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR). Major adverse cardiovascular events (MACEs) were assessed cumulatively during hospitalization and at 1, 6, and 12 months. Associations were evaluated using non-parametric tests, receiver operating characteristic analysis, Kaplan-Meier survival curves, and parsimonious logistic regression adjusted for GRACE score.Results: No inflammatory biomarker predicted in-hospital events. At 1-month, elevated SIRI was associated with MACEs (p = 0.017; AUC 0.77), identifying early post-discharge vulnerability. At 6 months, SII (p = 0.036), NLR (p = 0.031), and SIRI (p = 0.032) were associated with adverse outcomes with moderate discrimination (AUC ≈0.69). Associations were attenuated after adjustment for the GRACE score. Nobiomarker demonstrated consistent prognostic value at 12 months.Conclusions: Admission-derived inflammatory biomarkers show a dynamic prognostic profile after AMI.SIRI identifies early risk, while broader inflammatory activation relates to mid-term outcomes, suggesting complementary value for biomarker-based risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"471-482"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic and clinicopathological role of fibrinogen-to-albumin ratio in biliary tract cancers: a meta-analysis. 胆道肿瘤中纤维蛋白原与白蛋白比值的预后和临床病理作用：一项荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-19 DOI: 10.1080/17520363.2026.2691461

Yanchen Nie, Zongxin Zhang, Zhenghai Wu

{"title":"Prognostic and clinicopathological role of fibrinogen-to-albumin ratio in biliary tract cancers: a meta-analysis.","authors":"Yanchen Nie, Zongxin Zhang, Zhenghai Wu","doi":"10.1080/17520363.2026.2691461","DOIUrl":"10.1080/17520363.2026.2691461","url":null,"abstract":"Aims: Fibrinogen-to-albumin ratio (FAR) is investigated for the prognostic value of biliary tract cancers (BTCs), but outcomes were heterogenous. Consequently, the current meta-analysis was carried out for analyzing its precise prognostic impact on BTCs.Materials and methods: We systemically searched Web of Science, PubMed, Cochrane Library, and Embase till 20 November 2025. The significance of FAR in forecasting BTC overall survival (OS) along with recurrence-free survival (RFS) was examined through determining aggregate hazard ratios (HRs) alongside 95% confidence intervals (CIs).Results: There were nine articles enrolling 2071 cases collected for the present meta-analysis. As shown by our combined findings, higher FAR showed obvious correlation with decreased OS (HR = 2.34, 95% CI = 1.80-3.05, p < 0.001) and inferior RFS (HR = 2.07, 95% CI = 1.37-3.12, p < 0.001) of BTCs. Furthermore, from our combined data, higher FAR exhibited obvious correlation with low differentiation (OR = 1.71, 95% CI = 1.38-2.12, p < 0.001), lymph node (LN) metastasis (OR = 1.36, 95% CI = 1.05-1.76, p = 0.018), and advanced T stage (OR = 2.64, 95% CI = 1.78-3.93, p < 0.001) of BTCs.Conclusion: This meta-analysis demonstrated that elevated FAR was significantly associated with poor OS and inferior RFS in patients with BTCs. Moreover, high FAR was also tightly linked to low differentiation, LN metastasis, and higher T stage of BTCs.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"543-552"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum soluble CD163 as a predictor of intensive care need and mortality in community-acquired pneumonia. 血清可溶性CD163作为社区获得性肺炎重症监护需求和死亡率的预测因子

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-05-20 DOI: 10.1080/17520363.2026.2677197

Buğra Kerget, Ferhan Kerget, Burcu Nur Gülbahar, Mustafa Buğra Coşkuner, Ayşenur Sağ, Ahmet Kara, Alperen Aksakal, Esra Laloğlu

{"title":"Serum soluble CD163 as a predictor of intensive care need and mortality in community-acquired pneumonia.","authors":"Buğra Kerget, Ferhan Kerget, Burcu Nur Gülbahar, Mustafa Buğra Coşkuner, Ayşenur Sağ, Ahmet Kara, Alperen Aksakal, Esra Laloğlu","doi":"10.1080/17520363.2026.2677197","DOIUrl":"10.1080/17520363.2026.2677197","url":null,"abstract":"Aims: To evaluate the role of serum soluble CD163 (sCD163) in predicting intensive care unit (ICU) admission and mortality in patients with community-acquired pneumonia (CAP).Materials and methods: This prospective study included 135 participants (60 non-ICU CAP, 45 ICU CAP, and 30 healthy controls). Clinical and laboratory data were collected at admission. Serum sCD163 levels were measured using ELISA. Receiver operating characteristic (ROC) analysis and multivariate logistic regression were performed.Results: Patients requiring ICU care had significantly higher PSI, CURB-65, NLR, and sCD163 levels (all p < 0.05). sCD163 demonstrated strong predictive performance for ICU admission (AUC = 0.951, 95% CI 0.904-0.998), with a cutoff value of 4.94 ng/mL (sensitivity 96%, specificity 66%). In multivariate analysis, age and sCD163 levels were independently associated with in-hospital mortality (p < 0.05).Conclusion: Serum sCD163 is associated with disease severity, ICU requirement, and mortality in CAP. It may provide complementary value to established clinical scores for early risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"425-432"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis. ABO血型与胃癌结局之间的关系：kaplan - meier衍生的患者数据荟萃分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-01 Epub Date: 2026-06-11 DOI: 10.1080/17520363.2026.2678430

Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Rommel Mario Rodriguez Burbano, Mario Hiroyuki Hirata

{"title":"Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis.","authors":"Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Rommel Mario Rodriguez Burbano, Mario Hiroyuki Hirata","doi":"10.1080/17520363.2026.2678430","DOIUrl":"10.1080/17520363.2026.2678430","url":null,"abstract":"Background: Gastric cancer (GC) remains the fifth most common and lethal cancer worldwide, often diagnosed at advanced stages, with limited treatment options and poor survival. Beyond established risk factors, the ABO blood group system has been suggested as a potential prognostic factor, but evidence remains inconclusive.Methods: Medline, Scopus, and Web of Science were searched to 27 July 2025, for studies including GC patients with reported overall survival (OS) stratified by blood types O, A, B, and AB. Kaplan-Meier curves from eligible studies were digitized to reconstruct individual patient data, which were pooled to estimate median OS and hazard ratios (HR) using Cox regression.Results: Seven studies comprising 8,726 GC patients were included (O: 3,693; A: 946; B: 605; AB: 315). Median OS was highest for type O (85.1 months, 95% CI 77.5-86.4) and AB (78.2 months, 95% CI 73.9-NA), and lowest for type A (20.0 months, 95% CI 17.9-21.9) and B (35.5 months, 95% CI 27.9-78.5). Compared with non-O, type O had a significantly better prognosis (HR 0.63; p < 0.0001). Type A (HR 1.85; p < 0.0001) and type B (HR 1.20; p = 0.0018) were associated with worse survival, while type AB showed a favorable prognosis compared to non-AB (HR 0.83; p = 0.039).Conclusion: ABO blood group is a significant prognostic factor in GC, with types A and B linked to poorer survival.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"461-470"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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