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Prognostic value of triglyceride-glucose index for left ventricular remodeling in nondiabetic ST-elevation myocardial infarction patients 甘油三酯-葡萄糖指数对非糖尿病 ST 段抬高型心肌梗死患者左心室重构的预后价值
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-19 DOI: 10.2217/bmm-2024-0015
Tolga Han Efe, Engin Algül
{"title":"Prognostic value of triglyceride-glucose index for left ventricular remodeling in nondiabetic ST-elevation myocardial infarction patients","authors":"Tolga Han Efe, Engin Algül","doi":"10.2217/bmm-2024-0015","DOIUrl":"https://doi.org/10.2217/bmm-2024-0015","url":null,"abstract":"<p><b>Background:</b> The triglyceride-glucose (TyG) index is a marker of insulin resistance and is associated with cardiovascular mortality and morbidity. Left ventricular remodeling (LVR) after myocardial infarction (STEMI) is associated with poor prognosis. <b>Methods:</b> This retrospective study included 293 STEMI patients. Echocardiography was performed before discharge and 3 months after MI. <b>Results:</b> Compared with the non-LVR group, TyG index value was found to be higher in the LVR group (p &lt; 0.001). Logistic regression analysis showed that higher maximal troponin I value, higher calculated TyG index value, higher N-terminal prohormone of brain natriuretic peptide level and the presence of anterior MI were independently associated with the development of LVR. <b>Conclusion:</b> A high TyG index level may contribute to the prediction of LVR in nondiabetic STEMI patients undergoing successful primary percutaneous coronary intervention.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"27 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic role of C-reactive protein in patients with endometrial cancer: a meta-analysis 子宫内膜癌患者 C 反应蛋白的预后作用：一项荟萃分析
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-19 DOI: 10.2217/bmm-2023-0810
Xieyan Yu, Xiaoxing Zhang
{"title":"Prognostic role of C-reactive protein in patients with endometrial cancer: a meta-analysis","authors":"Xieyan Yu, Xiaoxing Zhang","doi":"10.2217/bmm-2023-0810","DOIUrl":"https://doi.org/10.2217/bmm-2023-0810","url":null,"abstract":"<p><b>Background:</b> The present meta-analysis aimed to explore the association between C-reactive protein (CRP) levels and the prognosis of patients with endometrial cancer (EC). <b>Methods:</b> The effect of CRP level on predicting overall survival (OS) and disease-free survival (DFS) in patients with EC was evaluated according to pooled hazard ratios (HRs) and corresponding 95% CIs. <b>Results:</b> High CRP levels were not significantly correlated with OS (HR: 1.32 [95% CI: 0.99–1.77]; p = 0.060) or DFS (HR: 1.05 [95% CI: 0.88–1.25]; p = 0.597) in patients with EC. <b>Conclusion:</b> CRP levels did not significantly predict OS or DFS in patients with EC. However, according to subgroup analyses, higher CRP levels were significantly associated with poor OS in Asian patients with EC.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"40 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer PLK3 与结直肠癌患者较高的肿瘤分期和不利的预后有关
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-17 DOI: 10.2217/bmm-2023-0591
Hai Zeng, Qian Wang, Ying Xiang, Yameng Yang, Xia Tu, Hui He, Shuang Li, Weijia Zhang
{"title":"PLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer","authors":"Hai Zeng, Qian Wang, Ying Xiang, Yameng Yang, Xia Tu, Hui He, Shuang Li, Weijia Zhang","doi":"10.2217/bmm-2023-0591","DOIUrl":"https://doi.org/10.2217/bmm-2023-0591","url":null,"abstract":"<p><b>Objective:</b> This study intended to explore the relationship of PLK3 with prognosis in patients with colorectal cancer (CRC). <b>Methods:</b> PLK3 positivity was detected by immunohistochemistry in 160 patients with CRC receiving surgical resection. <b>Results:</b> The median tumor PLK3-positive rate was 26.5%. Tumor PLK3-positive rate was related to increased lymph node stage (p = 0.002) and tumor–node–metastasis stage (p &lt; 0.001) of CRC. Tumor PLK3-positive rate ≥30% was related to shortened disease-free survival (p = 0.009) and overall survival (p = 0.003); tumor PLK3-positive rate ≥50% showed a stronger correlation with them (both p = 0.001), which was validated by multivariate Cox regression analyses (both p &lt; 0.05). <b>Conclusion:</b> Tumor PLK3-positive rate ≥50% relates to increased tumor stage and unfavorable survival in patients with CRC.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"48 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140615669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of pretreatment systemic immune-inflammation index in patients with endometrial cancer: a meta-analysis 子宫内膜癌患者治疗前全身免疫炎症指数的预后价值：一项荟萃分析
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-16 DOI: 10.2217/bmm-2023-0629
Pengtian Ji, Junjun He
{"title":"Prognostic value of pretreatment systemic immune-inflammation index in patients with endometrial cancer: a meta-analysis","authors":"Pengtian Ji, Junjun He","doi":"10.2217/bmm-2023-0629","DOIUrl":"https://doi.org/10.2217/bmm-2023-0629","url":null,"abstract":"<p><b>Background:</b> The present work focused on evaluating the systemic immune-inflammation index (SII) for its role in predicting endometrial cancer (EC) patient prognosis by meta-analysis. <b>Methods:</b> SII's role in predicting the prognosis of EC patients was analyzed by calculating combined hazard ratios (HRs) and 95% CIs. <b>Results:</b> As revealed by combined analysis, an increased SII predicted poor overall survival (HR = 2.01; 95% CI = 1.58–2.57; p &lt; 0.001) as well as inferior progression-free survival (HR = 1.87; 95% CI = 1.36–2.58; p &lt; 0.001) of EC. <b>Conclusion:</b> An increased SII score significantly predicted poor overall survival and progression-free survival in subjects with EC. The SII is suitable for predicting short- and long-term prognoses of patients with EC.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"94 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring novel perspectives on eosinophilic inflammation in severe asthma 探索重症哮喘中嗜酸性粒细胞炎症的新视角
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-16 DOI: 10.2217/bmm-2023-0801
Claudio Candia, Pasquale Ambrosino, Silvestro E D’Anna, Andrea Motta, Mauro Maniscalco
{"title":"Exploring novel perspectives on eosinophilic inflammation in severe asthma","authors":"Claudio Candia, Pasquale Ambrosino, Silvestro E D’Anna, Andrea Motta, Mauro Maniscalco","doi":"10.2217/bmm-2023-0801","DOIUrl":"https://doi.org/10.2217/bmm-2023-0801","url":null,"abstract":"<p>Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62L<sup>low</sup> inflammatory eosinophils (iEos) and identified an intriguing correlation between such iEos and asthma control scores. Moreover, CD62L<sup>low</sup> iEos were reduced after treatment with the anti-IL-5 monoclonal antibody mepolizumab. In the future, we believe that eosinophil subtypes could represent a useful biomarker in severe eosinophilic asthma, helping clinicians characterize patient endotypes and monitoring the response to biological drugs.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"86 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis B 组链球菌感染时血清炎症因子的变化及其对并发绒毛膜羊膜炎的胎膜早破的预测价值
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-04-16 DOI: 10.2217/bmm-2023-0588
Xiaorui Dong, Xixi Chen, Mengling Xue, Yina Zhang
{"title":"Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis","authors":"Xiaorui Dong, Xixi Chen, Mengling Xue, Yina Zhang","doi":"10.2217/bmm-2023-0588","DOIUrl":"https://doi.org/10.2217/bmm-2023-0588","url":null,"abstract":"<p><b>Objective:</b> The aim of this study as to unveil changes in serum inflammatory factors in pregnant women with genital tract group B <i>Streptococcus</i> (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes. <b>Methods:</b> The value of serum inflammatory factor levels in predicting PROM complicating CS and adverse pregnancy outcomes in GBS-infected pregnant women was evaluated by ELISA. <b>Results:</b> Serum IL-6, TNF-α, PCT and hs-CRP levels were higher in pregnant women with GBS infection. The combined diagnosis of these factors had excellent diagnostic value in PROM complicating CS and adverse pregnancy outcomes. <b>Conclusion:</b> Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"82 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients. PLK4 反映了甲状腺乳头状癌患者的甲状腺外侵袭、高肿瘤分期和不良预后。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0565
Xiaonan Hu, Jiawei Yu, Mengshi Chen, Rui Pang
{"title":"PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients.","authors":"Xiaonan Hu, Jiawei Yu, Mengshi Chen, Rui Pang","doi":"10.2217/bmm-2023-0565","DOIUrl":"10.2217/bmm-2023-0565","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to assess the value of PLK4 as a biomarker in papillary thyroid carcinoma (PTC). <b>Methods:</b> This study reviewed 230 PTC patients receiving surgical resections. PLK4 was detected in tumor tissues and samples of normal thyroid gland tissues by immunohistochemistry. <b>Results:</b> PLK4 was elevated in tumor tissues versus normal thyroid gland tissues (p < 0.001). Tumor PLK4 was linked with extrathyroidal invasion (p = 0.036), higher pathological tumor stage (p = 0.030), node stage (p = 0.045) and tumor/node/metastasis stage (p = 0.022) in PTC patients. Tumor PLK4 immunohistochemistry score >3 was linked with shortened disease-free survival (p = 0.026) and overall survival (p = 0.028) and independently predicted poorer disease-free survival (hazard ratio: 2.797; p = 0.040). <b>Conclusion:</b> Tumor PLK4 reflects extrathyroidal invasion, higher tumor stage and shortened survival in PTC.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"169-179"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients. 在多个时间点测量急性缺血性脑卒中患者血浆 LRG1 的预后效力。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0545
Juxian Gu, Chao Liu, Yan Yao
{"title":"Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients.","authors":"Juxian Gu, Chao Liu, Yan Yao","doi":"10.2217/bmm-2023-0545","DOIUrl":"10.2217/bmm-2023-0545","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to investigate the prognostic potency of LRG1 in acute ischemic stroke (AIS) patients. <b>Methods:</b> Plasma LRG1 levels were detected at admission and on days 3, 7 and 30 in 150 AIS patients. <b>Results:</b> LRG1 positively correlated with total cholesterol (p = 0.016), triglycerides (p = 0.046), C-reactive protein (p < 0.001), TNF-α (p = 0.001) and IL-6 (p = 0.004). After admission, LRG1 showed a decreasing trend (p < 0.001). Interestingly, LRG1 levels at admission (p = 0.014), day 3 (p = 0.027), day 7 (p = 0.008) and day 30 (p = 0.002) were higher in patients with modified Rankin scale score ≥2 versus those with scores <2. The LRG1 levels at day 7 (p = 0.032) and day 30 (p = 0.023) were higher in patients with recurrence versus no recurrence. <b>Conclusion:</b> LRG1 correlates with blood lipids, inflammation and short-term prognosis of AIS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"181-190"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction. CDC42和T-辅助细胞比率与ST段抬高型心肌梗死患者的焦虑、抑郁和生活质量的关系。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0712
Xuechao Wang, Junjie Feng, Shaohua Luan, Yong Zhou, Shipan Zhang, Hongling Su, Zhongyu Wang
{"title":"Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction.","authors":"Xuechao Wang, Junjie Feng, Shaohua Luan, Yong Zhou, Shipan Zhang, Hongling Su, Zhongyu Wang","doi":"10.2217/bmm-2023-0712","DOIUrl":"10.2217/bmm-2023-0712","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlations between CDC42 and T-cell subsets concerning anxiety, depression and quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention. <b>Methods:</b> Sera from 156 participants were analyzed for CDC42 levels and Th1, Th2, Th17 and Treg cells. <b>Results:</b> CDC42 correlated with reduced Th1/Th2 and Th17/Treg ratios, lower anxiety and depression, and higher EuroQol visual analog scale (EQ-VAS) score. The Th17/Treg ratio correlated with elevated anxiety, depression, EuroQol-5 dimensions score and decreased EQ-VAS score. The Th1/Th2 ratio was positively related to the EQ-VAS score. <b>Conclusion:</b> CDC42 correlates with reduced Th1/Th2 and Th17/Treg ratios, reduced anxiety and depression, and improved quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"157-168"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenomic biomarkers in coronary artery disease: a narrative review. 冠心病的药物基因组生物标志物：综述。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-03-01 Epub Date: 2024-03-08 DOI: 10.2217/bmm-2023-0476
Pamila Dua, Sandeep Seth, Bhavana Prasher, Mitali Mukerji, Subir Kumar Maulik, K H Reeta
{"title":"Pharmacogenomic biomarkers in coronary artery disease: a narrative review.","authors":"Pamila Dua, Sandeep Seth, Bhavana Prasher, Mitali Mukerji, Subir Kumar Maulik, K H Reeta","doi":"10.2217/bmm-2023-0476","DOIUrl":"10.2217/bmm-2023-0476","url":null,"abstract":"<p><p>Coronary artery disease (CAD) has a high mortality rate. Despite various therapeutic targets, non-responsiveness to drugs remains a prevalent issue. Pharmacogenomics assesses the way an individual's genetic attributes affect their likely response to drug therapy. Single-nucleotide polymorphisms play a crucial role in determining these outcomes. This review offers an overview of single-nucleotide polymorphisms investigated in clinical studies and their associations with drug response/nonresponse in the treatment of CAD. A total of 104 studies of whole sets of chromosomes and several genes were explored. A total of 161 polymorphisms exhibited associations with drug response/nonresponse in CAD across diverse ethnic populations. This pool can serve as a pharmacogenomic biomarker for predicting response to drug therapy in patients with CAD.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"191-202"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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