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Proteomic biomarkers profiling in Pakistani pancreatic ductal adenocarcinoma population: a retrospective cohort study. 巴基斯坦胰腺导管腺癌人群的蛋白质组生物标志物分析：一项回顾性队列研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-11-07 DOI: 10.1080/17520363.2024.2416888
Saleema Mehboob Ali, Yumna Adnan, Zubair Ahmad, Tabish Chawla, Sm Adnan Ali
{"title":"Proteomic biomarkers profiling in Pakistani pancreatic ductal adenocarcinoma population: a retrospective cohort study.","authors":"Saleema Mehboob Ali, Yumna Adnan, Zubair Ahmad, Tabish Chawla, Sm Adnan Ali","doi":"10.1080/17520363.2024.2416888","DOIUrl":"10.1080/17520363.2024.2416888","url":null,"abstract":"<p><p><b>Aim:</b> Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Research in various cancers suggests that investigating target biomarkers may provide directions to precision medicine. However, expression of biomarkers varies across different populations. The biomarker profile of Pakistani patients with PDAC remains unexplored.<b>Materials & methods:</b> We conducted a study on 109 patients to analyze a panel of four proteins (KRAS, p53, BRCA1 and APC) using formalin-fixed paraffin-embedded tumor samples. After confirmation of diagnosis and appropriate tumor content, tissues were processed with antibody specific immunohistochemistry experiments. Subsequently, independent microscopic observation was conducted by two pathologists using scoring criteria specific for each antibody.<b>Results:</b> Statistical analysis showed that negative expression of p53 was significantly associated with positive expression of BRCA1 (<i>p</i> = 0.000) and APC (<i>p</i> = 0.007). The expression of BRCA1 was also found significantly associated with APC (<i>p</i> = 0.028). None of the protein showed association with overall survival or patient demographics. Moreover, KRAS expression was shown to be significantly associated with perineural invasion (<i>p</i> = 0.005).<b>Conclusion:</b> This is the first study that investigates protein biomarker expression in a large cohort of Pakistani PDAC patients. The findings from the study may provide directions about the population specific biomarkers and targeted therapies for these patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"969-982"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between inflammatory markers and anemia in patients with diabetic foot ulcer. 糖尿病足溃疡患者的炎症指标与贫血之间的关系。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-11-13 DOI: 10.1080/17520363.2024.2421159
Jiawei Li, Wenzhuan Chen, Xueman Wen, Xuemei Jin, Ping Zhu, Chunjie Jiang
{"title":"Association between inflammatory markers and anemia in patients with diabetic foot ulcer.","authors":"Jiawei Li, Wenzhuan Chen, Xueman Wen, Xuemei Jin, Ping Zhu, Chunjie Jiang","doi":"10.1080/17520363.2024.2421159","DOIUrl":"10.1080/17520363.2024.2421159","url":null,"abstract":"<p><p><b>Aim:</b> Anemia of inflammation (AI) is common among patients with diabetic foot ulcers (DFU). This study aimed to investigate the specific relationship between inflammation indicators and anemia in patients with DFU.<b>Materials & methods:</b> This cross-sectional study was carried out among patients with DFU between 2018 and 2023. Clinical data were gathered before treatment. Restricted cubic spline regression was employed to investigate the non-linear associations between inflammation and anemia.<b>Results:</b> A total of 395 patients with Wagner grades 2-4 were enrolled in the study. About 63.54% of the patients with DFU had anemia which was primarily presented with normocytic hypopigmentation anemia. Elevated IL-6 levels (39.10-369 pg/ml) were significantly associated with an increased likelihood of anemia (OR = 4.84; 95% CI: 1.97-11.90). Similarly, high CRP levels (48.56-385 mg/l) were linked to a higher prevalence of anemia (OR = 5.01; 95% CI: 2.35-10.68). Furthermore, a nonlinear relationship was observed between CRP levels and anemia, suggesting that CRP values exceeding 53.889 mg/l may trigger anemia in patients with diabetic foot ulcers.<b>Conclusion:</b> Inflammation is identified as an independent risk factor for AI in patients with DFU. The inflammation indicators (CRP and IL-6) and anemia exhibit an L-shaped nonlinear correlation in patients with DFU.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1037-1047"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on red blood cell distribution width in children with severe Mycoplasma pneumoniae pneumonia. 关于重症肺炎支原体肺炎患儿红细胞分布宽度的研究
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0671
Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang
{"title":"Study on red blood cell distribution width in children with severe <i>Mycoplasma pneumoniae</i> pneumonia.","authors":"Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang","doi":"10.2217/bmm-2023-0671","DOIUrl":"10.2217/bmm-2023-0671","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to investigate the clinical value of the red blood cell distribution width (RDW) in severe <i>Mycoplasma pneumoniae</i> pneumonia (MPP). <b>Methods:</b> A total of 185 children with diagnosed severe MPP were included. The patients' case records and laboratory examination data were analyzed retrospectively. The children were grouped into quartiles based on RDW. <b>Results:</b> Univariate analysis revealed that RDW was significantly correlated with the Pediatric Risk of Mortality (PRISM) III score, Sepsis-Related Organ Failure Assessment score, incidence of invasive intubation and 30-day in-hospital mortality. After adjustment for the severity of illness, multivariate analysis revealed that the PRISM III score and RDW were factors independently associated with 30-day in-hospital mortality. <b>Conclusion:</b> This study revealed that RDW could be correlated with the long-term prognosis and severity of severe MPP.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"69-77"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between serum homocysteine and postoperative acute kidney injury in patients undergoing cardiac surgery. 心脏手术患者血清同型半胱氨酸与术后急性肾损伤之间的关系。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.2217/bmm-2023-0611
Zheng-Rong Li, Cun-Fei Liu, De-Qun Guo, Yan-Jin Wei
{"title":"Association between serum homocysteine and postoperative acute kidney injury in patients undergoing cardiac surgery.","authors":"Zheng-Rong Li, Cun-Fei Liu, De-Qun Guo, Yan-Jin Wei","doi":"10.2217/bmm-2023-0611","DOIUrl":"10.2217/bmm-2023-0611","url":null,"abstract":"<p><p><b>Background:</b> To explore the relationship between homocysteine (Hcy) and cardiac surgery-associated acute kidney injury (AKI). <b>Methods:</b> A total of 944 patients who underwent cardiac surgery were enrolled. The association between Hcy levels and the risk of cardiac surgery-associated AKI was evaluated. <b>Results:</b> A total of 135 patients were diagnosed with AKI and the prevalence of AKI was 14.30%. The AKI group had significantly higher levels of Hcy compared with the non-AKI group (16.90 vs 13.56 umol/l; p < 0.001). The incidence rates of AKI increased from 7.2% to 26.72% across increasing Hcy quartiles (p < 0.001). Compared with the first Hcy quartile group, the odds ratio of cardiac surgery-associated AKI was 4.43 (95% CI: 2.27-8.66) in the highest Hcy group. <b>Conclusion:</b> Elevated Hcy level is an independent risk factor for cardiac surgery-associated AKI.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"51-57"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of microRNA-486-5p in the diagnosis and the association with clinical symptoms of cervical cancer. microRNA-486-5p在宫颈癌诊断中的作用以及与临床症状的关联。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-17 DOI: 10.1080/17520363.2024.2400963
Lingling Wang, Yan Wang, Kang Yang, Xiaowen Hu, Guoliu Ye
{"title":"Roles of microRNA-486-5p in the diagnosis and the association with clinical symptoms of cervical cancer.","authors":"Lingling Wang, Yan Wang, Kang Yang, Xiaowen Hu, Guoliu Ye","doi":"10.1080/17520363.2024.2400963","DOIUrl":"10.1080/17520363.2024.2400963","url":null,"abstract":"<p><p><b>Aim:</b> To explore the predictive value of <i>miR-486-5p</i> in early cervical cancer and the associations of <i>miR-486-5p</i> with different clinical symptoms.<b>Materials & methods:</b> A total of 185 women were recruited. The relative expression levels of serum <i>miR-486-5p</i> were analyzed by real-time polymerase chain reaction. The receiver operator characteristic curves were utilized to reflect the predictive performance of <i>miR-486-5p</i> and squamous cell carcinoma antigen for early cervical cancer. Univariate logistic regression and ranked logistic regression were used to explore the associations of <i>miR-486-5p</i> with different clinical symptoms of early cervical cancer, with odd ratios (ORs) and 95% confidence intervals.<b>Results:</b> Eighty-one women (44.26%) had early cervical cancer. The relative expression of serum <i>miR-486-5p</i> was 1.99-fold higher in early cervical cancer patients than that in controls (<i>p</i> < 0.0001). The predictive performance of <i>miR-486-5p</i> for early cervical cancer was significantly superior to that of squamous cell carcinoma antigen, with an area under the curve of 0.865 (<i>p</i> < 0.001), sensitivity of 1.000 and specificity of 0.804. In addition, overexpressed <i>miR-486-5p</i> was associated with high odds of maximum tumor diameter increase (OR = 1.30, 95% CI: [1.01-1.66]).<b>Conclusion:</b> <i>MiR-486-5p</i> may be a potential biomarker for the early cervical cancer diagnosis, and was linked to the risk of maximum tumor diameter.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"869-876"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of pan immune-inflammation value in patients undergoing unprotected left main coronary artery stenting. 接受无保护左主干冠状动脉支架植入术的患者泛免疫炎症值的预后价值。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-21 DOI: 10.1080/17520363.2024.2412515
Ahmet Karaduman, Cemalettin Yılmaz, Mustafa Ferhat Keten, İsmail Balaban, Barkın Kültürsay, Neşri Danışman, Muhammet Mucahit Tiryaki, Elnur Alizade, Regayip Zehir
{"title":"Prognostic value of pan immune-inflammation value in patients undergoing unprotected left main coronary artery stenting.","authors":"Ahmet Karaduman, Cemalettin Yılmaz, Mustafa Ferhat Keten, İsmail Balaban, Barkın Kültürsay, Neşri Danışman, Muhammet Mucahit Tiryaki, Elnur Alizade, Regayip Zehir","doi":"10.1080/17520363.2024.2412515","DOIUrl":"10.1080/17520363.2024.2412515","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed long-term prognostic factors for percutaneous coronary intervention (PCI) in left main coronary artery (LMCA) disease, focusing on inflammatory parameters like Pan Immune-Inflammation Value (PIV) and Systemic Immune-Inflammation Index (SII).<b>Materials & methods:</b> This retrospective, observational study involved 121 patients receiving unprotected LMCA PCI.The study's primary end point was MACE, including all-cause death, repeat revascularization and myocardial reinfarction.<b>Results:</b> The PIV and SII scores emerged as independent predictors of MACE occurrence in patients undergoing PCI for unprotected LMCA disease (p:0.045,p:0.048;respectively).In addition, age, ejection fraction, creatinine, shock presentation and the residual syntax score were identified as significant independent predictors of MACE in both models.<b>Conclusion:</b> This study showed a significant, independent correlation between PIV, SII and MACE in patients undergoing PCI for LMCA disease, with PIV showing slightly better predictive capability than SII.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"957-967"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review. 皮肤病中的长非编码 RNA MALAT1：综述。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-07-09 DOI: 10.1080/17520363.2024.2369044
Dayanara Ruiz-Ojeda, Carlos A Guzmán-Martín, Rafael Bojalil, Ximena F Balderas, Iris S Paredes-González, Javier González-Ramírez, Enrique Torres-Rasgado, Adrián Hernández-DíazCouder, Rashidi Springall, Fausto Sánchez-Muñoz
{"title":"Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review.","authors":"Dayanara Ruiz-Ojeda, Carlos A Guzmán-Martín, Rafael Bojalil, Ximena F Balderas, Iris S Paredes-González, Javier González-Ramírez, Enrique Torres-Rasgado, Adrián Hernández-DíazCouder, Rashidi Springall, Fausto Sánchez-Muñoz","doi":"10.1080/17520363.2024.2369044","DOIUrl":"10.1080/17520363.2024.2369044","url":null,"abstract":"<p><p>Dermatologic disorders, affecting the integumentary system, involve diverse molecular mechanisms such as cell proliferation, apoptosis, inflammation and immune responses. Long noncoding RNAs, particularly Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1), are crucial regulators of gene expression. MALAT1 influences inflammatory responses, immune cell function and signaling pathways, impacting various physiological and pathological processes, including dermatologic disorders. Dysregulation of MALAT1 is observed in skin conditions like psoriasis, atopic dermatitis and systemic lupus erythematosus. However, its precise role remains unclear. This review consolidates knowledge on MALAT1's impact on skin biology and pathology, emphasizing its potential diagnostic and therapeutic implications in dermatologic conditions.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"853-867"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study. 分析恶性肿瘤的静脉血栓栓塞风险：血栓弹力图和凝血因子研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1080/17520363.2024.2342239
Wang Xue-Xing, Chu Jie, Chen Chun-Mei, He Yuan, Wei Chun-Mei
{"title":"Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study.","authors":"Wang Xue-Xing, Chu Jie, Chen Chun-Mei, He Yuan, Wei Chun-Mei","doi":"10.1080/17520363.2024.2342239","DOIUrl":"10.1080/17520363.2024.2342239","url":null,"abstract":"<p><p><b>Aim:</b> This retrospective clinical study was designed to examine the predictive value of thromboelastography (TEG) combined with coagulation function for venous thromboembolism (VTE) in hospitalized patients with cancer. <b>Materials & methods:</b> Among 215 patients admitted between May 2020 and January 2022, 39 (18.14%) were diagnosed with VTE during hospitalization. <b>Results:</b> Significant differences were found in D-dimer, ATIII and TEG parameters (maximum amplitude and coagulation index) between VTE-positive and VTE-negative patients (p < 0.05). Multivariate analysis revealed tumor node metastasis stage, concomitant infection, smoking history and D-dimer as independently associated with VTE. The constructed model and D-dimer areas under the curve were 0.809 and 0.764, respectively. <b>Conclusion:</b> TEG parameters were not significantly predictive indicators for VTE, with D-dimer remaining a key predictor.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 8","pages":"373-383"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of serum albumin in heart failure patients with cardiac resynchronization therapy. 接受心脏再同步化治疗的心力衰竭患者血清白蛋白的预后价值。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2347200
Levent Pay, Ahmet Çağdaş Yumurtaş, Ozan Tezen, Tuğba Çetin, Semih Eren, Tufan Çınar, Mert İlker Hayıroğlu
{"title":"Prognostic value of serum albumin in heart failure patients with cardiac resynchronization therapy.","authors":"Levent Pay, Ahmet Çağdaş Yumurtaş, Ozan Tezen, Tuğba Çetin, Semih Eren, Tufan Çınar, Mert İlker Hayıroğlu","doi":"10.1080/17520363.2024.2347200","DOIUrl":"10.1080/17520363.2024.2347200","url":null,"abstract":"<p><p><b>Aim:</b> There is a lack of data about the association between admission serum albumin levels and long-term mortality in heart failure (HF) patients with cardiac resynchronization therapy defibrillators (CRT-D). We aim to investigate this connection in HF patients with CRT-D. <b>Methods:</b> The study population consisted of 477 HF patients with CRT-D. The cohort was divided into three groups according to albumin values, and the relationship between these groups and long-term mortality were evaluated. <b>Results:</b> Long-term all-cause mortality (HR: 3.32, 95% CI: 2.12-6.84), appropriate (HR: 4.44, 95% CI: 2.44-8.06) and inappropriate (HR: 2.95, 95% CI: 1.88-6.02) shocks were higher in the low albumin group. <b>Conclusion:</b> Low albumin levels are associated with the long-term mortality and appropriate shock treatment in HF patients with CRT-D.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 8","pages":"363-371"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic role of systemic immune-inflammation index versus other cardiac markers in acute myocarditis in young adults. 全身免疫炎症指数与其他心脏标记物在青壮年急性心肌炎中的预后作用。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-25 DOI: 10.1080/17520363.2024.2403321
Ilke Erbay, Ugur Kokturk, Naile Eris Gudul, Ahmet Avci
{"title":"Prognostic role of systemic immune-inflammation index versus other cardiac markers in acute myocarditis in young adults.","authors":"Ilke Erbay, Ugur Kokturk, Naile Eris Gudul, Ahmet Avci","doi":"10.1080/17520363.2024.2403321","DOIUrl":"10.1080/17520363.2024.2403321","url":null,"abstract":"<p><p><b>Aim:</b> Myocarditis, an inflammatory disease of the myocardium, can range from asymptomatic cases to severe forms such as fulminant myocarditis. The systemic immune-inflammation index (SII) has emerged as a potential biomarker for various inflammatory diseases. This study aimed to determine the effect of SII on the prognosis of young adults with acute myocarditis and compare it with other cardiac markers.<b>Methods:</b> We retrospectively analyzed patients aged 18-40 years who were admitted to the emergency department with a diagnosis of acute myocarditis between January 2014 and January 2024. Patients were divided into non-fulminant and fulminant myocarditis groups based on diagnostic criteria.<b>Results:</b> SII, troponin I and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in the fulminant myocarditis group (<i>p</i> < 0.001 for all). Logistic regression analysis identified SII and NT-proBNP as independent predictors of fulminant myocarditis but not for troponin I (<i>p</i> = 0.064). The optimal cutoff value for SII in diagnosing fulminant myocarditis was 1020, with a sensitivity of 91% and specificity of 83%, outperforming troponin I. Patients with SII ≥1020 had a significantly higher risk of adverse outcomes.<b>Conclusion:</b> The SII enables early detection of adverse outcomes and is an independent predictor of prognosis in young adults with myocarditis.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"889-897"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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