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Relation between LRG1 and CD4+ T cells, cognitive impairment and neurological function in patients with acute ischemic stroke. 急性缺血性脑卒中患者的 LRG1 和 CD4+ T 细胞、认知障碍和神经功能之间的关系。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.2217/bmm-2023-0674
Xiao Cheng, Hongen Wei, Yi Liu, Yaxuan Sun, Jianxin Ye, Pengyu Lu, Bin Han
{"title":"Relation between LRG1 and CD4<sup>+</sup> T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.","authors":"Xiao Cheng, Hongen Wei, Yi Liu, Yaxuan Sun, Jianxin Ye, Pengyu Lu, Bin Han","doi":"10.2217/bmm-2023-0674","DOIUrl":"10.2217/bmm-2023-0674","url":null,"abstract":"<p><p><b>Objective:</b> To assess the relationship between LRG1 and CD4<sup>+</sup> T cells, cognitive impairment and neurological function in acute ischemic stroke (AIS). <b>Methods:</b> Plasma LRG1 was detected by ELISA in 175 patients with AIS at baseline, day (D) 1, D7, month (M) 1 and M3. <b>Results:</b> LRG1 was negatively related to Th2 and Treg cells and positively linked to Th17 (all p < 0.05). LRG1 increased from baseline to D1, then decreased until M3 (p < 0.001). LRG1 at each assessment point was increased in patients with cognitive impairment or poor neurological function at M3 versus those without (all p < 0.05). <b>Conclusion:</b> LRG1 is linked to decreased Th2 and Tregs, increased Th17, cognitive impairment and nonideal neurological function recovery in patients with AIS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"5-14"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma. MECOM：通过生物信息学和实验鉴定的肺腺癌诊断和预后标志物。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0600
Anqi Li, Meng Li, Jing Wang, Jiejun Zhou, Tian Yang, Meng Fan, Kun Zhang, Hengxing Gao, Hui Ren, Mingwei Chen
{"title":"MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma.","authors":"Anqi Li, Meng Li, Jing Wang, Jiejun Zhou, Tian Yang, Meng Fan, Kun Zhang, Hengxing Gao, Hui Ren, Mingwei Chen","doi":"10.2217/bmm-2023-0600","DOIUrl":"10.2217/bmm-2023-0600","url":null,"abstract":"<p><p><b>Objective:</b> We aimed to explore the clinical value of MDS1 and EVI1 complex locus (<i>MECOM</i>) in lung adenocarcinoma (LUAD). <b>Methods:</b> Bioinformatics and experimental validation confirmed <i>MECOM</i> expression levels in LUAD. The value of <i>MECOM</i> was analyzed by receiver operating characteristic (ROC) curve and Cox regression analysis. <b>Results:</b> Serum MECOM levels were lower in LUAD and correlated with gender, TNM stage, tumor size, lymph node metastasis and distant metastasis. The ROC curve showed that the area under the curve of MECOM was 0.804 for LUAD and, of note, could reach 0.889 for advanced LUAD; specificity was up to 90%. <b>Conclusion:</b> <i>MECOM</i> may contribute to independently identifying LUAD patients, particularly in advanced stages.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"79-91"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum HIF-1α, IGF-1 and IGFBP-3 correlate to recurrence and overall survival in early-stage hepatocellular carcinoma patients. 血清 HIF-1α、IGF-1 和 IGFBP-3 与早期肝细胞癌患者的复发和总生存期有关。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17520363.2024.2421149
Shujun Ding, Wei Ding, Ye Zhang, Yunbao Chen, Hongtao Tang, Xiao Jiang, Jun Chen
{"title":"Serum HIF-1α, IGF-1 and IGFBP-3 correlate to recurrence and overall survival in early-stage hepatocellular carcinoma patients.","authors":"Shujun Ding, Wei Ding, Ye Zhang, Yunbao Chen, Hongtao Tang, Xiao Jiang, Jun Chen","doi":"10.1080/17520363.2024.2421149","DOIUrl":"10.1080/17520363.2024.2421149","url":null,"abstract":"<p><p><b>Aim:</b> Recurrence of hepatocellular carcinoma (HCC) after ultrasound-guided microwave ablation (UGMWA) was a critical issue. Therefore, it is significant to identify the role of hypoxia-inducible factor 1 α (HIF-1α), insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in recurrence.<b>Materials & methods:</b> HCC patients receiving UGMWA were divided into recurrence and no-recurrence groups. The preoperative and postoperative risk factors were compared between these two groups.<b>Results:</b> Preoperative and postoperative serum levels of HIF-1α, IGF-1 and IGFBP-3 were closely associated with the recurrence of HCC. Serum HIF-1α level was increased, while serum levels of IGF-1 and IGFBP-3 were decreased in HCC patients with recurrence.<b>Conclusion:</b> HIF-1α, IGF-1 and IGFBP-3 were associated with and predicted the recurrence of HCC after UGMWA, respectively or in combination.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1027-1036"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments. 基线甘油三酯-葡萄糖、体重指数、左心房舒张末期内径和肌酐是冠心病患者经皮冠状动脉介入治疗后肺动脉高压的独立预测指标。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-11-20 DOI: 10.1080/17520363.2024.2422807
Li Xie, Shilin Fu, Yuzheng Xu, Litong Ran, Jing Luo, Rongsheng Rao, Jianfei Chen, Shi-Zhu Bian, Dehui Qian
{"title":"Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments.","authors":"Li Xie, Shilin Fu, Yuzheng Xu, Litong Ran, Jing Luo, Rongsheng Rao, Jianfei Chen, Shi-Zhu Bian, Dehui Qian","doi":"10.1080/17520363.2024.2422807","DOIUrl":"10.1080/17520363.2024.2422807","url":null,"abstract":"<p><p><b>Aim:</b> To identify the predictive role of triglyceride-glucose (TyG) index in pulmonary hypertension (PH) in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) treatment.<b>Methods:</b> Blood biomarkers have been measured at the cross-section of entrance. The baseline and followed-up echocardiography have been performed at both cross-sections.<b>Results:</b> The incidence of PH was 8.91%. The baseline myoglobin (MYO), was significantly higher among PH patients (<i>p</i> < 0.001). In the univariate regression, body mass index (BMI <i>p</i> = 0.020), left atria end-diastolic internal diameter (LAD, <i>p</i> = 0.083), creatinine (Cr, <i>p</i> = 0.005), triglyceride (TG, <i>p</i> < 0.001), high-density lipoprotein cholesterol (HDL-C, <i>p</i> = 0.056) and TyG index (<i>p</i> = 0.002) were potential predictors for PH. Finally, the adjusted COX regression indicated that BMI (<i>p</i> = 0.001), LAD (<i>p</i> = 0.030), Cr(<i>p</i> = 0.005) and TyG index (<i>p</i> = 0.002) were independent predictors of the onset of PH.<b>Conclusion:</b> Baseline TyG index, BMI, LAD, Cr level were independent predictors for PH in CAD patients after PCI treatment.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1049-1059"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of AT in acute pulmonary embolism with pleural effusion. 评估急性肺栓塞伴胸腔积液的 AT。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-11-27 DOI: 10.1080/17520363.2024.2395241
Lianbiao Yang, Kexin Dong, Beibei Zhang, Qirui Mu, Yuxin Xia, Tuanli Bai, Zhaoxing Cui, Jin Yang, Hongyuan Kong, Zhenkun Li
{"title":"Evaluation of AT in acute pulmonary embolism with pleural effusion.","authors":"Lianbiao Yang, Kexin Dong, Beibei Zhang, Qirui Mu, Yuxin Xia, Tuanli Bai, Zhaoxing Cui, Jin Yang, Hongyuan Kong, Zhenkun Li","doi":"10.1080/17520363.2024.2395241","DOIUrl":"10.1080/17520363.2024.2395241","url":null,"abstract":"<p><p><b>Aim:</b> We aimed to investigate whether there is a correlation between AT and pleural effusion in PE patients.<b>Materials & methods:</b> We retrospectively enrolled 325 patients aged 66.26 ± 14.86 years with acute PE in 256-computed tomography pulmonary angiography (CTPA) from 2015 to 2022 and recorded radiographic, clinical and biomarker data, the patients were divided into two groups, PE with pleural effusion group (178 patients) and PE without pleural effusion group (147 patients), odds ratios (OR) were estimated for AT of pleural effusion in PE.<b>Results:</b> A lower AT had a significantly increased risk of pleural effusion (adjusted OR: 2.009, 95% CI: 1.225-3.295).<b>Conclusion:</b> AT are reduced in PE patients with pleural effusion and are associated with the risk of pleural effusion.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1017-1026"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of salivary melatonin levels in patients with bruxism: a case-control study. 磨牙症患者唾液褪黑激素水平的比较评估：一项病例对照研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1080/17520363.2024.2398982
Ceyda Gürhan, Ercan Saruhan, Ali Batuhan Bayırlı
{"title":"Comparative evaluation of salivary melatonin levels in patients with bruxism: a case-control study.","authors":"Ceyda Gürhan, Ercan Saruhan, Ali Batuhan Bayırlı","doi":"10.1080/17520363.2024.2398982","DOIUrl":"10.1080/17520363.2024.2398982","url":null,"abstract":"<p><p><b>Aim:</b> To examine whether there is any difference in the levels of salivary melatonin between bruxism and nonbruxism groups and to compare the stress and anxiety levels between the two groups.<b>Materials & methods:</b> Patients meeting the probable bruxism criteria according to the International Consensus on the Assessment of Bruxism Criteria were included in the bruxism group. The salivary melatonin concentrations of both groups were measured using an ELISA kit. To determine the relationship between stress and bruxism, the State-Trait Anxiety Inventory (STAI) test was used.<b>Results:</b> The bruxism group had a significantly lower night-time salivary melatonin level than the control group (<i>p</i> < 0.05). No significant difference was determined between the bruxism group and the control group in respect of the STAI-T scores (<i>p</i> > 0.05).<b>Conclusion:</b> The study findings revealed a strong relationship between a low melatonin level and bruxism.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"843-851"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indices and ferritin level that predict organ involvement in adult-onset Still's disease. 预测成人型斯蒂尔病器官受累的指标和铁蛋白水平。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-24 DOI: 10.1080/17520363.2024.2403330
Mehmet Nur Kaya, Özlem Kılıç, Ezgi Çimen Güneş, Duygu Tecer, Sedat Yılmaz
{"title":"Indices and ferritin level that predict organ involvement in adult-onset Still's disease.","authors":"Mehmet Nur Kaya, Özlem Kılıç, Ezgi Çimen Güneş, Duygu Tecer, Sedat Yılmaz","doi":"10.1080/17520363.2024.2403330","DOIUrl":"10.1080/17520363.2024.2403330","url":null,"abstract":"<p><p><b>Aim:</b> The aim of the study is to evaluate whether C-reactive protein to albumin ratio (CAR), lactate dehydrogenase to albumin ratio (LAR), ferritin to erythrocyte sedimentation rate ratio (FER), systemic immune-inflammation index (SII), prognostic nutritional index (PNI) indices and ferritin level can predict organ involvement in adult-onset Still's disease (AOSD) patients.<b>Methods:</b> This study was planned as a cross-sectional study. Univariate and multivariate logistic regression analyses were performed to evaluate the usefulness of ferritin level and inflammatory indices in defining organ involvement.<b>Results:</b> Sixty-one patients diagnosed with AOSD were included in this study. Multivariate logistic regression analyzes showed that LAR (OR 1.028, 95% CI: 1.011-1.044) (<i>p</i> = 0.001) index predicted lymphadenopathy involvement, CAR (OR 1.249, 95% CI: 1.087-1.435) (<i>p</i> = 0.002) index predicted hepatomegaly involvement, ferritin level (OR 1.004, 95% CI: 1.001-1.008) (<i>p</i> = 0.007) predicted splenomegaly involvement, FER (OR 1.085, 95% CI: 1.012-1.164) (<i>p</i> = 0.021) and PNI (OR 0.271, 95% CI: 1.132-0.553) (<i>p</i> < 0.001) index predicted the occurrence of serositis.<b>Conclusion:</b> This study showed that ferritin level, CAR, FER, PNI and LAR markers may predict organ involvement at diagnosis in AOSD patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"899-906"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-6 and stroke recurrence in ischemic stroke. IL-6 与缺血性中风的中风复发。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/17520363.2024.2389038
Yuanfeng Jiang, Tao Fan
{"title":"IL-6 and stroke recurrence in ischemic stroke.","authors":"Yuanfeng Jiang, Tao Fan","doi":"10.1080/17520363.2024.2389038","DOIUrl":"10.1080/17520363.2024.2389038","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to evaluate the predictive value of IL-6 for stroke recurrence in acute ischemic stroke.<b>Methods:</b> Patients who were admitted within 48 h of onset were included. At 3-month, stroke recurrence was assessed. IL-6 levels were measured in serum samples taken upon admission.<b>Results:</b> Out of the 305 patients, 47 (15.4%) experienced a stroke recurrence. The risk of stroke recurrence increased by 8% (OR: 1.08; 95% CI: 1.04-1.11; <i>p</i> < 0.001) for every 1 pg/ml increase in IL-6 serum level, both in unadjusted and adjusted analyses (6%; OR: 1.06; 95% CI: 1.02-1.10; <i>p</i> = 0.001).<b>Conclusion:</b> The study supports the usefulness of IL-6 as a predictive biomarker for stroke recurrence after acute ischemic stroke.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"739-747"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KELIM score predicts outcome in patients with platinum-resistant/refractory recurrent ovarian cancer. KELIM 评分可预测铂类耐药/难治性复发性卵巢癌患者的预后。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-17 DOI: 10.1080/17520363.2024.2352409
Pauline Corbaux, Olivier Colomban, Aurore Carrot, Benoit You
{"title":"KELIM score predicts outcome in patients with platinum-resistant/refractory recurrent ovarian cancer.","authors":"Pauline Corbaux, Olivier Colomban, Aurore Carrot, Benoit You","doi":"10.1080/17520363.2024.2352409","DOIUrl":"10.1080/17520363.2024.2352409","url":null,"abstract":"","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"509-510"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood-based biomarkers and novel technologies for the diagnosis of colorectal cancer and adenomas: a narrative review. 诊断结直肠癌和腺瘤的血液生物标记物和新技术：综述。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-20 DOI: 10.1080/17520363.2024.2345583
Drew Magowan, Mansour Abdulshafea, Dominic Thompson, Shri-Ishvarya Rajamoorthy, Rhiannon Owen, Dean Harris, Susan Prosser
{"title":"Blood-based biomarkers and novel technologies for the diagnosis of colorectal cancer and adenomas: a narrative review.","authors":"Drew Magowan, Mansour Abdulshafea, Dominic Thompson, Shri-Ishvarya Rajamoorthy, Rhiannon Owen, Dean Harris, Susan Prosser","doi":"10.1080/17520363.2024.2345583","DOIUrl":"10.1080/17520363.2024.2345583","url":null,"abstract":"<p><p><b>Aim:</b> Blood-based biomarkers have shown promise for diagnosing colorectal cancer (CRC) and adenomas (CRA). This review summarizes recent studies in this area. <b>Methods:</b> A literature search was undertaken for 01/01/2017-01/03/2023. Criteria included CRC, CRA, liquid-biopsy, blood-based tests and diagnosis. <b>Results:</b> 12,378 studies were reduced to 178 for data extraction. Sixty focused on proteomics, 53 on RNA species, 30 on cfDNA methylation, seven on antigens and autoantibodies and 28 on novel techniques. 169 case control and nine cohort studies. Number of participants ranged 100-54,297, mean age 58.26. CRC sensitivity and specificity ranged 9.10-100% and 20.40-100%, respectively. CRA sensitivity and specificity ranged 8.00-95.70% and 4.00-97.00%, respectively. <b>Conclusion:</b> Sensitive and specific blood-based tests exist for CRC and CRA. However, studies demonstrate heterogenous techniques and reporting quality. Further work should concentrate on validation and meta-analyzes.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"493-506"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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