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Biomarkers in medicine最新文献

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Potential biomarkers in breast cancer drug development: application of the biomarker qualification evidentiary framework. 乳腺癌药物开发中的潜在生物标志物：生物标志物资格证据框架的应用。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-03-15 DOI: 10.2217/bmm-2023-0048
Eric Wang, Mackenzie Henderson, Priyanka Yalamanchili, Jenilee Cueto, Zahidul Islam, Charles Dharmani, Maribel Salas
{"title":"Potential biomarkers in breast cancer drug development: application of the biomarker qualification evidentiary framework.","authors":"Eric Wang, Mackenzie Henderson, Priyanka Yalamanchili, Jenilee Cueto, Zahidul Islam, Charles Dharmani, Maribel Salas","doi":"10.2217/bmm-2023-0048","DOIUrl":"10.2217/bmm-2023-0048","url":null,"abstract":"<p><p>Breast cancer treatments have evolved rapidly, and clinically meaningful biomarkers have been used to guide therapy. These biomarkers hold utility within the drug development process to increase the efficiency and effectiveness. To this purpose, the US FDA developed an evidentiary framework. Literature searches conducted of literature published between 2016 and 2022 identified biomarkers in breast cancer. These biomarkers were reviewed for drug development utility through the biomarker qualification evidentiary framework. In the breast cancer setting, several promising biomarkers (ctDNA, Ki-67 and PIK3CA) were identified. There is a need for increased transparency regarding the requirements for qualification of specific biomarkers and increased awareness of the processes involved in biomarker qualification.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"265-277"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between coagulation and inflammatory system in liver disease: re-focus on hematological markers. 肝病中凝血和炎症系统之间的相互作用：重新关注血液标记物。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/17520363.2024.2395245
Liuyi Lu, Chunling Zhu, Dongyi Zhou, Siting Li, Liling Yi, Shangmou Wei, Qiliu Peng
{"title":"Interaction between coagulation and inflammatory system in liver disease: re-focus on hematological markers.","authors":"Liuyi Lu, Chunling Zhu, Dongyi Zhou, Siting Li, Liling Yi, Shangmou Wei, Qiliu Peng","doi":"10.1080/17520363.2024.2395245","DOIUrl":"10.1080/17520363.2024.2395245","url":null,"abstract":"<p><p><b>Aim:</b> This study uses blood routine, coagulation and biochemical indicators to explore the relationship between the hematological parameters of patients with various types of liver diseases.<b>Methods:</b> The Kruskal-Wallis, Chi-squared and Fisher exact tests were used to compare the hematological parameters and clinical characteristics of three groups of patients with different degrees of liver disease. Spearman correlation analysis is used to analyze the correlation between two continuous variables. The logistic regression model evaluated the odds ratio between variables and disease changes. Receiver operating characteristic curve analysis was used to understand the predictive value of each index in relation to the progress of liver disease.<b>Results:</b> There are differences in inflammation and coagulation profiles among different types of liver diseases and there is a correlation between them. In addition to the traditional marker α-fetoprotein, the inflammatory marker c-reactive protein and the coagulation marker D-dimer also have good diagnostic value for liver injury.<b>Conclusion:</b> The coagulation and inflammation systems interact, are connected and play essential roles in the liver.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"813-822"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between NT-proBNP levels and existing/de novo QRS fragmentation in patients with myocardial infarction. 心肌梗死患者的 NT-proBNP 水平与现有/新生 QRS 分段之间的关系。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2345584
Hamza Sunman, Engin Algül, Muhammet Dural, Muhammet Erzurum, Faruk Aydınyılmaz, Tolga Han Efe, Tolga Çimen
{"title":"Relationship between NT-proBNP levels and existing/<i>de novo</i> QRS fragmentation in patients with myocardial infarction.","authors":"Hamza Sunman, Engin Algül, Muhammet Dural, Muhammet Erzurum, Faruk Aydınyılmaz, Tolga Han Efe, Tolga Çimen","doi":"10.1080/17520363.2024.2345584","DOIUrl":"https://doi.org/10.1080/17520363.2024.2345584","url":null,"abstract":"<p><p><b>Aim:</b> to assess the evolution of fragmented QRS (fQRS) and NT-proBNP levels during myocardial infarction (MI).<b>Methods:</b> Among 511 patients, 205 (40.1%) had fQRS, with 54 (26.3%) developing de novo fragmentation during hospitalization.<b>Results:</b> NT-proBNP levels were significantly higher in the fQRS+ group compared with the fQRS- group (1555 vs. 796 pg/ml, p < 0.001). NT-proBNP levels were higher in patients with de novo fragmentation than in those without (2852 vs. 1370 pg/ml, p = 0.011). The incidence of major adverse cardiovascular events was notably higher in fQRS+ patients compared with fQRS- patients (p = 0.001).<b>Conclusion:</b> In acute MI, there was a significant association between fQRS and NT-proBNP levels, with higher NT-proBNP levels observed in those with de novo fQRS compared with those without.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 10-12","pages":"535-544"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aurora-B: a novel biomarker in the invasion and metastasis of osteosarcoma. 极光-B：骨肉瘤侵袭和转移的新型生物标记物
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/17520363.2024.2366160
Siping Long, Yanxin Zhong, Jiaming Liu
{"title":"Aurora-B: a novel biomarker in the invasion and metastasis of osteosarcoma.","authors":"Siping Long, Yanxin Zhong, Jiaming Liu","doi":"10.1080/17520363.2024.2366160","DOIUrl":"10.1080/17520363.2024.2366160","url":null,"abstract":"<p><p>Osteosarcoma (OS), a primary human malignant tumor that affects the bones, mostly arises in children and adolescents. Even though surgical resection followed by radiotherapy and chemotherapy has improved the survival rate up to 60%, the long-term positive effect for most patients with OS is not satisfactory. Hence, elucidating the specific mechanisms involved in the pathogenesis of OS is particularly important. Aurora-B, a serine/threonine kinase, plays a crucial role in centrosome regulation, spindle formation and chromosomal separation during mitosis. It has been found that Aurora-B overexpression is related to the occurrence and development of several malignant tumors, including OS. This article summarizes the role of Aurora-B in the invasion and metastasis of OS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"639-647"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio in glaucoma: a meta-analysis. 青光眼中血小板与淋巴细胞比率和淋巴细胞与单核细胞比率：一项荟萃分析。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-02-09 DOI: 10.2217/bmm-2023-0651
Shu-Han Chuang, Cheng-Hsien Chang
{"title":"Platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio in glaucoma: a meta-analysis.","authors":"Shu-Han Chuang, Cheng-Hsien Chang","doi":"10.2217/bmm-2023-0651","DOIUrl":"10.2217/bmm-2023-0651","url":null,"abstract":"<p><p><b>Aim:</b> To explore the association between two systemic inflammation markers, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and glaucoma. <b>Materials & methods:</b> The authors searched PubMed, Embase and the Cochrane Library for eligible studies comparing PLR and LMR levels in glaucoma patients and healthy controls. <b>Results:</b> Analysis revealed that glaucoma patients exhibited significantly elevated PLR levels and reduced LMR compared with nonglaucoma controls. These findings were consistent across various glaucoma types, with the exception of secondary glaucoma, where the association with PLR was less significant. <b>Conclusion:</b> The authors found PLR and LMR to be potential valuable biomarkers for glaucoma identification and progression monitoring. These findings highlight the role of systemic inflammation in glaucoma pathogenesis.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"39-49"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRAMEF12, a novel cancer/testis gene, regulates proliferation and apoptosis to promote progression of glioma. PRAMEF12 是一种新型癌/睾丸基因，它能调节胶质瘤的增殖和凋亡，从而促进胶质瘤的发展。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-24 DOI: 10.2217/bmm-2023-0219
Jiaqiang Li, Jianhua Zhong, Aifa Tang, Jianchun Yin, Shoulin Li
{"title":"<i>PRAMEF12</i>, a novel cancer/testis gene, regulates proliferation and apoptosis to promote progression of glioma.","authors":"Jiaqiang Li, Jianhua Zhong, Aifa Tang, Jianchun Yin, Shoulin Li","doi":"10.2217/bmm-2023-0219","DOIUrl":"10.2217/bmm-2023-0219","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate whether <i>PRAMEF12</i> can serve as a diagnostic biomarker for glioma. <b>Methods:</b> We examined <i>PRAMEF12</i> expression in multiple normal and glioma tissues. The diagnostic value of <i>PRAMEF12</i> was evaluated using receiver operating characteristic curve analysis. The effect of <i>PRAMEF12</i> ablation on proliferation, cell cycle and apoptosis was investigated. Database analyses were utilized for functional enrichment analysis. <b>Results:</b> <i>PRAMEF12</i> expression in normal tissue was restricted to the human testis. <i>PRAMEF12</i> displayed significant diagnostic value in glioma. <i>PRAMEF12</i> knockdown inhibited cell proliferation, induced apoptosis and resulted in induction of S-phase cell cycle arrest. Pathway enrichment analysis indicated that <i>PRAMEF12</i> may participate in cancer. <b>Conclusion:</b> <i>PRAMEF12</i>, a novel cancer/testis gene, may be a potential new diagnostic biomarker for glioma.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"385-397"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel metabolic biomarkers for the diagnosis of acute ischemic stroke. 用于诊断急性缺血性中风的新型代谢生物标记物。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI: 10.1080/17520363.2024.2389033
Zhenzhen Tang, Baoli Xu, Junjun Wang, Wenzhen Wang, Shanshan Sha, Yongjin Sun
{"title":"Novel metabolic biomarkers for the diagnosis of acute ischemic stroke.","authors":"Zhenzhen Tang, Baoli Xu, Junjun Wang, Wenzhen Wang, Shanshan Sha, Yongjin Sun","doi":"10.1080/17520363.2024.2389033","DOIUrl":"10.1080/17520363.2024.2389033","url":null,"abstract":"<p><p><b>Aim:</b> To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS).<b>Methods:</b> The metabolites in the sera of 63 patients with AIS aged 45∼77 years and 60 healthy individuals were analyzed by liquid chromatography (LC)-mass spectrometry (MS)/MS. The efficiency of significantly altered metabolites as biomarkers of AIS was evaluated by ROC curve analysis.<b>Results:</b> Different metabolic profiles were revealed in AIS patients' sera compared with healthy persons. Twelve significantly altered metabolites had an area under the curve (AUC) value >0.80, demonstrating their potential as a biomarker of AIS. Among them, six metabolites are firstly reported to distinguish between AIS patients and healthy individuals.<b>Conclusion:</b> These 12 metabolites can be further researched as potential diagnostic biomarkers of AIS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"727-737"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspective: metabolomics has the potential to change the landscape of kidney transplantation diagnostics. 视角：代谢组学有可能改变肾移植诊断的格局。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI: 10.1080/17520363.2024.2394383
Dirk R J Kuypers, Jurre J Kamphorst, Henriette de Loor, Elizabeth M O'Day
{"title":"Perspective: metabolomics has the potential to change the landscape of kidney transplantation diagnostics.","authors":"Dirk R J Kuypers, Jurre J Kamphorst, Henriette de Loor, Elizabeth M O'Day","doi":"10.1080/17520363.2024.2394383","DOIUrl":"10.1080/17520363.2024.2394383","url":null,"abstract":"<p><p>Kidney transplantation is the most efficient renal replacement therapy. Current diagnostics for monitoring graft health are either invasive or lack precision. Metabolomics is an emerging discipline focused on the analysis of the small molecules involved in metabolism. Given the kidneys' central role in metabolic homeostasis and previous observations of altered metabolites correlating with restricted kidney graft function, metabolomics is highly promising for the discovery of novel biomarkers and the development of novel diagnostics. In this perspective, we summarize the known metabolic roles for the kidney, discuss biomarkers of graft health and immune status emerging from metabolomics research, and provide our perspective on how these and future findings can be integrated in clinical practice to enable precision diagnostics.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"787-794"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Naples prognostic score to predict long-term mortality in patients with pulmonary embolism. 评估预测肺栓塞患者长期死亡率的那不勒斯预后评分。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-03-15 DOI: 10.2217/bmm-2023-0741
Levent Pay, Tuğba Çetin, Kıvanç Keskin, Şeyda Dereli, Ozan Tezen, Ahmet Ç Yumurtaş, Zeynep Kolak, Semih Eren, Faysal Şaylık, Tufan Çınar, Mert I Hayıroğlu
{"title":"Evaluation of Naples prognostic score to predict long-term mortality in patients with pulmonary embolism.","authors":"Levent Pay, Tuğba Çetin, Kıvanç Keskin, Şeyda Dereli, Ozan Tezen, Ahmet Ç Yumurtaş, Zeynep Kolak, Semih Eren, Faysal Şaylık, Tufan Çınar, Mert I Hayıroğlu","doi":"10.2217/bmm-2023-0741","DOIUrl":"10.2217/bmm-2023-0741","url":null,"abstract":"<p><p><b>Background:</b> The Naples prognostic score (NPS), which reflects the inflammatory and nutritional status of patients, is often used to determine prognosis in cancer patients. The aim of this study was to determine the long-term prognostic value of the NPS in acute pulmonary embolism (APE) patients. <b>Methods:</b> Two hundred thirty-nine patients diagnosed with APE were divided into two groups according to their NPS, and long-term mortality was compared. <b>Results:</b> The long-term mortality was observed in 38 patients out of 293 patients in the mean follow-up of 24 months. Multivariate analysis showed that NPS as a categorical parameter and NPS as a numeric parameter were independent predictors of long-term mortality. <b>Conclusion:</b> This study highlights that NPS may have the potential to predict long-term mortality in APE patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"253-263"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A non-enhancing, T2 fluid-attenuated inversion recovery hyperintense, diffusion-restricting brainstem lesion in an EGFR tyrosine kinase inhibitor-treated non-small-cell lung cancer patient. 一名接受表皮生长因子受体酪氨酸激酶抑制剂治疗的非小细胞肺癌患者脑干出现非增强、T2流体增强反转恢复高强化、弥散限制性病变。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2342231
Carlen A Yuen, Silin Bao, Xiao-Tang Kong
{"title":"A non-enhancing, T2 fluid-attenuated inversion recovery hyperintense, diffusion-restricting brainstem lesion in an EGFR tyrosine kinase inhibitor-treated non-small-cell lung cancer patient.","authors":"Carlen A Yuen, Silin Bao, Xiao-Tang Kong","doi":"10.1080/17520363.2024.2342231","DOIUrl":"10.1080/17520363.2024.2342231","url":null,"abstract":"<p><p>Leptomeningeal metastasis (LM) is a devastating complication of malignancy. Diagnosis relies on both contrast enhancement on imaging and malignant cells in cerebral spinal fluid cytology. Though early detection and prompt intervention improves survival, the detection of LM is limited by false negatives. A rare brainstem imaging finding uncovered specifically in <i>EGFR</i> mutation-positive lung cancer patients may represent an early sign of LM. This sign demonstrates high signal on T2 fluid-attenuated inversion recovery and diffusion-weighted imaging sequences, but paradoxically lacks correlative contrast enhancement. Here we report a case of a 72-year-old female <i>EGFR</i>-positive lung cancer patient who developed this lesion following treatment with two first-generation <i>EGFR</i> tyrosine kinase inhibitors then showed subsequent response to osimertinib, an irreversible third-generation <i>EGFR</i> tyrosine kinase inhibitor.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 9","pages":"431-439"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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