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Prognostic value of NOB1 expression levels in various cancers: a systematic review and meta-analysis. NOB1表达水平在各种癌症中的预后价值：系统综述和荟萃分析。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-17 DOI: 10.1080/17520363.2024.2352408
Yi Zhang, Zheng Li, Xi Chen, Ying Huang, Bingwen Zou, Yong Xu
{"title":"Prognostic value of NOB1 expression levels in various cancers: a systematic review and meta-analysis.","authors":"Yi Zhang, Zheng Li, Xi Chen, Ying Huang, Bingwen Zou, Yong Xu","doi":"10.1080/17520363.2024.2352408","DOIUrl":"10.1080/17520363.2024.2352408","url":null,"abstract":"<p><p><b>Aim:</b> This study evaluates the prognostic significance of <i>NOB1</i> expression levels in various cancers.<b>Patients & methods:</b> Studies examining NOB1 expression in cancer, encompassing data from 1694 patients across 14 studies, were analyzed for overall survival (OS) and progression-free survival (PFS) using hazard ratios (HRs) and 95% CIs, and for clinicopathological parameters using relative risks (RRs).<b>Results:</b> High <i>NOB1</i> expression correlated with shorter OS (HR: 2.12, 95% CI: 1.82-2.48) and PFS (HR: 2.23, 95% CI: 1.62-3.07) and was associated with adverse tumor characteristics such as stage and metastasis.<b>Conclusion:</b> Elevated <i>NOB1</i> expression in various tumors signifies a poor prognosis, serving as a predictive marker for malignancy outcomes.<b>PROSPERO Register Number:</b> CRD42023394051.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"619-628"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential clinical significance of ALDH3B1 in auxiliary diagnosis of gastric cancer. ALDH3B1 在胃癌辅助诊断中的潜在临床意义
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-02-09 DOI: 10.2217/bmm-2023-0418
Chenxue Tang, Jing Xu, Ming Zheng, Dongchen Qian, Zhihua Gao, Xian Li, Weiwei Zhang
{"title":"Potential clinical significance of ALDH3B1 in auxiliary diagnosis of gastric cancer.","authors":"Chenxue Tang, Jing Xu, Ming Zheng, Dongchen Qian, Zhihua Gao, Xian Li, Weiwei Zhang","doi":"10.2217/bmm-2023-0418","DOIUrl":"10.2217/bmm-2023-0418","url":null,"abstract":"<p><p><b>Objective:</b> This research aimed to explore a diagnostic method based on serum <i>ALDH3B1</i> and to evaluate the clinical diagnostic efficacy in gastric cancer (GC) by comparing it with the traditional GC diagnostic method, the carcinoembryonic protein (CEA) assay. <b>Methods:</b> Serum samples were collected from 70 healthy volunteers and various patients (GC: 76, benign gastric lesions: 20, postoperative: 37, recurrence: 56). The diagnostic efficacy of serum <i>ALDH3B1</i>, CEA and the co-diagnosis were evaluated by receiver operating characteristic curve. ALDH3B1 protein levels were evaluated by western blot. <b>Results:</b> The co-diagnosis of <i>ALDH3B1</i> and CEA had the highest diagnostic efficacy (area under the curve = 0.841). <b>Conclusion:</b> Serum <i>ALDH3B1</i> may be used as an auxiliary diagnostic biomarker for GC, and its co-diagnosis with CEA can improve diagnostic efficacy.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"15-23"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
sEH activity is associated with mortality in patients with ARDS: a retrospective cohort study. sEH 活性与 ARDS 患者死亡率的关系：一项回顾性队列研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-08-13 DOI: 10.1080/17520363.2024.2377534
Dong Guangsu, Zhou Liang, Wang Bin, Liu Lei, Cao Peiyu
{"title":"sEH activity is associated with mortality in patients with ARDS: a retrospective cohort study.","authors":"Dong Guangsu, Zhou Liang, Wang Bin, Liu Lei, Cao Peiyu","doi":"10.1080/17520363.2024.2377534","DOIUrl":"10.1080/17520363.2024.2377534","url":null,"abstract":"<p><p><b>Aim:</b> We hypothesized plasma sEH activity correlates with mortality in acute respiratory distress syndrome (ARDS) patients.<b>Methods:</b> Adult patients diagnosed with ARDS enrolled between 2017 and 2019 were included in this study.<b>Results:</b> A total of 337 adult patients met our inclusion criteria. Among them, 107 patients died within 28 days. The plasma sEH activity was higher in nonsurvivors relative to survivors. And a receiver operating characteristic curve with the area under the curve of 0.81 (95% confidence interval: 0.74-0.89) for the prediction of 28-day mortality was obtained. Its sensitivity and specificity were 72.5% and 74.6%, respectively.<b>Conclusion:</b> Elevated plasma sEH activity is associated with higher 28-day mortality in adult patients with ARDS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"659-664"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of nutrition for contrast-induced nephropathy in patients undergoing peripheral vascular intervention. 外周血管介入治疗患者造影剂诱发肾病的营养预后价值。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/17520363.2024.2395248
Ahmet Karaduman, Cemalettin Yılmaz, Mustafa Ferhat Keten, İsmail Balaban, Faysal Saylık, Elnur Alizade, Regayip Zehir
{"title":"Prognostic value of nutrition for contrast-induced nephropathy in patients undergoing peripheral vascular intervention.","authors":"Ahmet Karaduman, Cemalettin Yılmaz, Mustafa Ferhat Keten, İsmail Balaban, Faysal Saylık, Elnur Alizade, Regayip Zehir","doi":"10.1080/17520363.2024.2395248","DOIUrl":"10.1080/17520363.2024.2395248","url":null,"abstract":"<p><p><b>Background:</b> The objective was to examine the predictive value of malnutrition, assessed via the Controlling Nutritional status (CONUT) and Prognostic Nutrition Index (PNI) scores, in the development of contrast-associated acute kidney injury (CA-AKI) following peripheral vascular intervention (PVI).<b>Methods:</b> This retrospective cross-sectional observational study included the enrollment of 243 consecutive patients who underwent PVI. Patients were categorized into two groups based on the occurrence of CA-AKI.<b>Results:</b> Patients with CA-AKI had lower PNI scores and the PNI score was an independent predictor of CA-AKI development (Odds Ratio: 0.518, 95% CI: 2.295-0.908, <i>p</i> = 0.021). Nomogram had higher discriminative ability than both PNI and CONUT scores and discriminative abilities were similar for PNI and CONUT scores.<b>Conclusion:</b> Malnutrition, as identified by the CONUT and PNI, was found to be associated with a high risk of CA-AKI development following PVI.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"801-811"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyponatremia as a predictor of complicated appendicitis: a systematic review and meta-analysis. 低钠血症作为复杂性阑尾炎的预测因素：系统综述和荟萃分析。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1080/17520363.2024.2403332
Huili Shi, Lifang Shen
{"title":"Hyponatremia as a predictor of complicated appendicitis: a systematic review and meta-analysis.","authors":"Huili Shi, Lifang Shen","doi":"10.1080/17520363.2024.2403332","DOIUrl":"10.1080/17520363.2024.2403332","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the value of hyponatremia as a predictive marker for complicated appendicitis.<b>Methods:</b> PubMed, Embase, Web of Science and Scopus databases were searched for studies published up to 5 June 2024. Studies reporting serum sodium levels in patients with complicated and non-complicated appendicitis and studies reporting the association between baseline hyponatremia and complicated appendicitis were included. A random-effects meta-analysis was performed.<b>Results:</b> Twenty-two studies met the eligibility criteria. Serum sodium levels were measured at arrival or preoperatively in all included studies. Meta-analysis of data from 17 studies showed that preoperative sodium levels were significantly lower in patients with complicated appendicitis vs uncomplicated appendicitis [Mean Difference (MD): -2.58 95% confidence intervals (CI): -3.51, -1.66 I<sup>2</sup> = 98%]. A pooled analysis of 18 studies demonstrated a statistically significant association between preoperative hyponatremia and complicated appendicitis [Odds Ratio (OR): 4.11 95% CI: 3.07, 5.51 I<sup>2</sup> = 93%]. Results remained significant on subgroup analysis for adult and pediatric populations. However, the MD was higher and the OR was higher in the subgroup of pediatric patients.<b>Conclusion:</b> Hyponatremia was identified as a potential predictor for complicated appendicitis. The association between hyponatremia and complicated appendicitis seems to be stronger in pediatric patients as compared with adults.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"927-936"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of serum salusin-α and β levels in patients with obstructive sleep apnea. 评估阻塞性睡眠呼吸暂停患者的血清黄豆素-α 和 β 水平。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-07-09 DOI: 10.1080/17520363.2024.2366151
Buğra Kerget, Dursun Erol Afşin, Esra Laloglu
{"title":"Evaluation of serum salusin-α and β levels in patients with obstructive sleep apnea.","authors":"Buğra Kerget, Dursun Erol Afşin, Esra Laloglu","doi":"10.1080/17520363.2024.2366151","DOIUrl":"10.1080/17520363.2024.2366151","url":null,"abstract":"<p><p><b>Aim:</b> Salusin-α and salusin-β peptides are crucial in the development of cardiovascular diseases like coronary artery disease (CAD). This study compared serum levels of these peptides in patients with obstructive sleep apnea (OSA), those with both OSA and CAD.<b>Materials & methods:</b> Patients without OSA were included in Group 1, those with OSA alone comprised Group 2, and those with OSA and CAD were in Group 3.<b>Results:</b> Salusin-α level was significantly higher in controls than in Groups 2 and 3, while salusin-β levels were significantly higher in Groups 2 and 3 compared with the control group.<b>Conclusion:</b> Salusin-α and -β levels may be parameters that can guide the diagnosis of OSA in patients with a consistent clinical history.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"603-610"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical value of combined detection of seven lung cancer-related autoantibodies in assisting the diagnosis of non-small-cell lung cancer. 联合检测七种肺癌相关自身抗体对辅助诊断非小细胞肺癌的临床价值。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1080/17520363.2024.2404379
Guozhu Chen, Ping'an Guo, Haiping Zhao, Dejun Zhao, Dan Yang
{"title":"The clinical value of combined detection of seven lung cancer-related autoantibodies in assisting the diagnosis of non-small-cell lung cancer.","authors":"Guozhu Chen, Ping'an Guo, Haiping Zhao, Dejun Zhao, Dan Yang","doi":"10.1080/17520363.2024.2404379","DOIUrl":"10.1080/17520363.2024.2404379","url":null,"abstract":"<p><p><b>Aim:</b> Evaluate the clinical value of lung-cancer-related autoantibodies (CAGE, GAGE7, GBU4-5, MAGEA1, P53, PGP9.5, SOX2) in auxiliary diagnosis of non-small-cell lung cancer (NSCLC).<b>Methods:</b> We detected the concentrations of above 7 antibodies and lung cancer markers (CEA, NSE, CYFRE21-1) and drew area under the receiver characteristic curve of 316 patients.<b>Results:</b> The concentrations of CAGE, GBU4-5, MAGEA1, P53, PGP9.5 and SOX2 of significantly higher than other groups (<i>p</i> < 0.01). The sensitivity of different stages and pathological types of NSCLC consistent. Among them, the sensitivity of combined-detection in diagnosing adenocarcinoma and squamous cell carcinoma significantly better than CEA, NSE and CYFRA21-1.<b>Conclusion:</b> The combined detection has better efficacy in assisting the diagnosis of NSCLC and has certain clinical promotion and application value.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"917-925"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The difference in core-surface temperature indicates the prognosis of heart failure patients. 核心表面温度的差异预示着心衰患者的预后。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2342233
Bingzhang Jie, Ling Han, Liwei Chen, Ming Yang
{"title":"The difference in core-surface temperature indicates the prognosis of heart failure patients.","authors":"Bingzhang Jie, Ling Han, Liwei Chen, Ming Yang","doi":"10.1080/17520363.2024.2342233","DOIUrl":"10.1080/17520363.2024.2342233","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the difference between core temperature and surface temperature (ΔT) as an index for the prognosis of heart failure (HF). <b>Patients & methods:</b> Core temperature and surface temperature were measured in 253 patients with HF. The association of ΔT with prognostic indicators of HF was analyzed. <b>Results:</b> Patients with ΔT ≥2°C were more likely to have lower left ventricular ejection fraction and lower estimated glomerular filtration rate, higher levels of troponin T, brain natriuretic peptide and procalcitonin, and high blood urea nitrogen/creatinine ratio. The risk of death increased by 32% for a 1°C increase in ΔT and was 4.36-times higher in the ΔT ≥2°C group than in the ΔT <2°C group. <b>Conclusion:</b> ΔT may be used to predict the prognosis of patients with HF.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 9","pages":"441-448"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
α-1 antitrypsin is promising for the identification of glaucoma severity and is associated with glaucomatous neural damage. α-1抗胰蛋白酶有望用于识别青光眼的严重程度，并与青光眼神经损伤有关。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-08-13 DOI: 10.1080/17520363.2024.2347190
Hang Yuan, An Li, Lingling Chen, Zuo Wang, Xiong Zhu, Jinxia Wang, Wenbo Xiu, Yang Chen, Gao Zhang, Donghua Liu, Xiao Xiao, Chaonan Sun, Fang Lu, Lijuan Hu, Chong He
{"title":"α-1 antitrypsin is promising for the identification of glaucoma severity and is associated with glaucomatous neural damage.","authors":"Hang Yuan, An Li, Lingling Chen, Zuo Wang, Xiong Zhu, Jinxia Wang, Wenbo Xiu, Yang Chen, Gao Zhang, Donghua Liu, Xiao Xiao, Chaonan Sun, Fang Lu, Lijuan Hu, Chong He","doi":"10.1080/17520363.2024.2347190","DOIUrl":"10.1080/17520363.2024.2347190","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the association between plasma AAT level and glaucoma.<b>Methods:</b> 163 glaucoma patients and 111 healthy controls were recruited. The plasma AAT levels were measured by ELISA.<b>Results:</b> Plasma AAT level was significantly higher in glaucoma patients than those in healthy controls (<i>p</i> < 0.001). Patients with higher plasma AAT level exhibited severer disease stage (early vs. severe: <i>p</i> < 0.05; H-P-A; early vs. severe: <i>p</i> < 0.05; early vs. end-stage: <i>p</i> < 0.01; AGIS). ROC curves yielded that AAT can distinguish patients with early glaucoma from those with advanced glaucoma (early vs. severe: AUC: 0.616; H-P-A; early vs. severe: AUC: 0.763; early vs. end-stage: AUC: 0.660; AGIS).<b>Conclusion:</b> Plasma AAT is a useful biomarker for the identification of glaucoma severity.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"545-553"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers: paving the way for diagnosis, prognosis and disease monitoring. Welcome to Volume 18. 生物标志物：为诊断、预后和疾病监测铺平道路。欢迎阅读第 18 卷。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 DOI: 10.2217/bmm-2023-0807
Afra Paleel
{"title":"Biomarkers: paving the way for diagnosis, prognosis and disease monitoring. Welcome to Volume 18.","authors":"Afra Paleel","doi":"10.2217/bmm-2023-0807","DOIUrl":"10.2217/bmm-2023-0807","url":null,"abstract":"","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 1","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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