Biomarkers in medicine最新文献_第9页

Association between Castelli risk index and cardiovascular and cerebrovascular mortality in elderly type 2 diabetes mellitus patients. 老年2型糖尿病患者Castelli危险指数与心脑血管死亡率的关系

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI: 10.1080/17520363.2026.2631636

Ruiang Wang, Yuan Liu, Xiaokun Yang, Yiming Wang, Liubao Gu, Huihui Wang

{"title":"Association between Castelli risk index and cardiovascular and cerebrovascular mortality in elderly type 2 diabetes mellitus patients.","authors":"Ruiang Wang, Yuan Liu, Xiaokun Yang, Yiming Wang, Liubao Gu, Huihui Wang","doi":"10.1080/17520363.2026.2631636","DOIUrl":"10.1080/17520363.2026.2631636","url":null,"abstract":"Background: The Castelli Risk Index (CRI) is an atherogenic index to assess cardiovascular disease risk. But the predictive value of CRI in assessing the risk of cardiovascular and cerebrovascular disease (CCVD)-related death in elderly patients with type 2 diabetes mellitus (T2DM) remains unclear.Methods: This retrospective cohort study analyzed clinical data from the SDTM Study, which began in 2005, including 888 patients aged ≥60 years with T2DM. Baseline lipid parameters and deaths related to CCVD during follow-up were recorded in hospital ward or outpatient clinic. The association between CRI and CCVD mortality was assessed by the Cox proportional hazards model. A competing-risk model was additionally employed to evaluate the association.Results: After a median follow-up of 7.62 years, 40 CCVD deaths occurred. The -CRI-I predicted CCVD deaths in elderly T2DM patients (HR: 1.35, 95% CI: 1.02 - 1.78, p = 0.038) after fully adjusting for age, gender, smoking, drinking, AST, ALT, creatinine, Fasting Blood Glucose, and use of statin. -Subgroup analysis showed that CCVD deaths were more strongly associated with CRI-I among females, those not taking statins, and those without coronary heart disease or hypertension.Conclusions: CRI -can independently predict CCVD mortality in elderly T2DM patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"109-117"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation biomarkers for short term risk stratification in tricuspid valve intervention. 新一代生物标志物在三尖瓣介入治疗中的短期风险分层。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-02-16 DOI: 10.1080/17520363.2026.2628970

Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter

{"title":"Next-generation biomarkers for short term risk stratification in tricuspid valve intervention.","authors":"Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter","doi":"10.1080/17520363.2026.2628970","DOIUrl":"10.1080/17520363.2026.2628970","url":null,"abstract":"Background: Interventional therapies for tricuspid regurgitation are rapidly evolving, yet optimal patient selection remains challenging. Conventional biomarkers such as NT-proBNP may inadequately reflect the complex pathophysiology and clinical risk in this population. Emerging biomarkers-including soluble suppression of tumorigenicity 2 (sST2), soluble urokinase-type plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP), and growth differentiation factor-15 (GDF-15)-remain insufficiently studied in patients undergoing transcatheter tricuspid valve interventions.Methods: This prospective, single-center observational cohort study enrolled consecutive patients undergoing transcatheter treatment for severe tricuspid regurgitation, including transcatheter edge-to-edge repair and heterotopic caval valve implantation. Pre-procedural blood samples were collected and analyzed for GDF-15, suPAR, H-FABP, and sST2 using standardized assays. Prognostic performance for the composite endpoint of all-cause mortality or heart-failure rehospitalization within three months was assessed using receiver-operating-characteristic analysis and multivariable Cox regression.Results: Sixty patients (mean age 80.3 ± 7.3 years; 48.3% male) were included. At three months, 12 patients (20%) were rehospitalized and 6 (10%) had died. GDF-15 (AUC 0.867) and suPAR (AUC 0.885) demonstrated strong predictive accuracy and outperformed NT-proBNP. GDF-15 >1,400 pg/mL independently predicted adverse outcomes (HR 2.03, p = 0.046).Conclusion: GDF-15 and suPAR provide incremental prognostic value for short-term risk stratification after transcatheter tricuspid valve intervention.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"129-139"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and prognostic value of inflammatory markers for patients with severe pneumonia: a meta-analysis. 炎症标志物对重症肺炎患者的诊断和预后价值：一项荟萃分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2025-11-24 DOI: 10.1080/17520363.2025.2580286

Meng Han, Can Zhang, Songhe Zhao, Hongyun Zhang

{"title":"Diagnostic and prognostic value of inflammatory markers for patients with severe pneumonia: a meta-analysis.","authors":"Meng Han, Can Zhang, Songhe Zhao, Hongyun Zhang","doi":"10.1080/17520363.2025.2580286","DOIUrl":"10.1080/17520363.2025.2580286","url":null,"abstract":"Aims: This meta-analysis evaluates the diagnostic and prognostic performance of severe pneumonia through a comprehensive meta-analysis.Patients and methods: A systematic literature search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and Scopus. Studies were included if they focused on severe pneumonia patients, assessed relevant inflammatory markers, and provided sufficient data for meta-analysis.Results: The diagnostic meta-analysis found a sensitivity of 0.72 (95% CI: 0.64-0.79) and a specificity of 0.75 (95% CI: 0.70-0.80). Area under the summary receiver operating characteristic curve was 0.80 (95% CI: 0.76-0.83). However, these pooled estimates showed high heterogeneity (I2 > 80%), indicating substantial variation across studies and requiring cautious interpretation. Subgroup analyses revealed that procalcitonin (PCT) had the highest specificity. For predicting short-term mortality, a preliminary analysis of five studies (n = 463) showed a pooled sensitivity of 0.72 (95% CI: 0.64-0.79) and a specificity of 0.65 (95% CI: 0.59-0.70), suggesting a potential prognostic signal that needs validation in larger, prospective cohorts.Conclusions: Inflammatory markers are valuable auxiliary tools to support clinical judgment in assessing severity and predicting outcomes in patients with severe pneumonia. They offer moderate accuracy in distinguishing severe from non-severe cases and in predicting short-term mortality.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"57-68"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum inflammatory and coagulation markers in GBS infection and adverse pregnancy outcomes. GBS感染和不良妊娠结局的血清炎症和凝血标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2025-08-22 DOI: 10.1080/17520363.2025.2538429

Lin Li, Xiaoying Wang, Dan Li, Zhenfang Liu

{"title":"Serum inflammatory and coagulation markers in GBS infection and adverse pregnancy outcomes.","authors":"Lin Li, Xiaoying Wang, Dan Li, Zhenfang Liu","doi":"10.1080/17520363.2025.2538429","DOIUrl":"10.1080/17520363.2025.2538429","url":null,"abstract":"Objective: To investigate the relationship between Group B Streptococcus (GBS) infection in pregnant women and adverse pregnancy events (APEs), as well as serum inflammatory factors (IFs) and coagulation parameters.Methods: A retrospective analysis was conducted on 2,200 late-pregnancy women who delivered at Maternal and Child Health Hospital from March 2020 to January 2023. Data on GBS infection, serotyping, immunofluorescence, coagulation parameters, and APEs were collected. APE incidence was compared between groups, and logistic regression was performed to analyze inflammatory factors and coagulation parameters in GBS-positive women with and without APEs.Results: Among the participants, 593 (26.95%) were GBS-positive, and 1,607 (73.05%) were GBS-negative. The GBS-positive group had significantly higher rates of preterm birth, intrauterine infection, premature rupture of membranes, placental abruption, postpartum hemorrhage, and meconium-stained amniotic fluid compared to the GBS-negative group (p < 0.05). Logistic regression identified white blood cell count, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6 (IL-6), interleukin-1β, procalcitonin, and fibrinogen as independent risk factors for APEs (p < 0.05).Conclusion: GBS infection increases the risk of adverse pregnancy events and is closely associated with alterations in inflammatory and coagulation markers.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"17-25"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NF-κB p65 as a predictive biomarker of low-grade inflammation in ART-treated HIV-1 infection: comparison with HS-CRP. NF-κB p65作为抗逆转录病毒治疗的HIV-1感染低级别炎症的预测性生物标志物：与HS-CRP的比较

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-02-14 DOI: 10.1080/17520363.2026.2628972

Sivasubramaniyan Gnanaskandan, Urmila Karunakaran, Sathyamurthy P, Jotheeswaran T, Padma Srikanth

{"title":"NF-κB p65 as a predictive biomarker of low-grade inflammation in ART-treated HIV-1 infection: comparison with HS-CRP.","authors":"Sivasubramaniyan Gnanaskandan, Urmila Karunakaran, Sathyamurthy P, Jotheeswaran T, Padma Srikanth","doi":"10.1080/17520363.2026.2628972","DOIUrl":"10.1080/17520363.2026.2628972","url":null,"abstract":"Background: Low-grade inflammation remains a clinical concern in virally suppressed people living with HIV-1 (PWH). Identifying reliable biomarkers is essential for monitoring inflammation-related risk.Methods: This exploratory cross-sectional study evaluated NF-κB p65 as a biomarker in 60 virally suppressed HIV-1 infected individuals and 60 controls. NF-κB p65 and high-sensitive C-reactive protein (HS-CRP) levels were quantified. Statistical analyses were performed in R (v4.3.2) using multivariable logistic regression model, adjusting for age, gender, HS-CRP, and socio-economic status. Predictive performance was assessed using AUC, calibration, and decision curve analysis. Additional analysis includes principal component analysis (PCA), k-means clustering, and linear regression was performed.Results: NF-κB p65 levels were significantly elevated in PWH than controls (p < 0.001), while HS-CRP was not independently associated. NF-κB p65 remained the strongest predictor of low-grade inflammation (OR = 2.3, AUC = 0.816) than HS-CRP. The model demonstrated good calibration and clinical utility. PCA and k-means clustering revealed heterogenous inflammatory profiles, and NF-κB p65 showed a borderline inverse association with CD4+ T cell counts. Low SES was also linked to increased inflammation (p < 0.001).Conclusion: NF-κB p65 is a promising biomarker for monitoring subclinical inflammation in virally suppressed HIV-1 infection.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"47-55"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for effective prognosis of polycystic ovary syndrome: a full review. 多囊卵巢综合征有效预后的生物标志物：全面回顾。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-01-29 DOI: 10.1080/17520363.2026.2622044

Ishanka Singh, Anuja Pant, Pawan Kumar Maurya

{"title":"Biomarkers for effective prognosis of polycystic ovary syndrome: a full review.","authors":"Ishanka Singh, Anuja Pant, Pawan Kumar Maurya","doi":"10.1080/17520363.2026.2622044","DOIUrl":"10.1080/17520363.2026.2622044","url":null,"abstract":"Introduction: Polycystic ovary syndrome (PCOS) is a complicated endocrine condition marked by reproductive, metabolic and chronobiological perturbations. Despite a number of biomarkers that can be used in its diagnosis, they only show the existence of the syndrome and not much information about prognosis. This prognostic blindness complicates disease management and contributes to increased healthcare and economic burden.Areas covered: The review summarizes the literature on prognostic biomarkers in PCOS, including hormone biomarkers, metabolic biomarkers, circadian regulatory biomarkers, and non-coding RNAs. Clinical, observational, and preclinical findings indicate that these markers reflect early molecular and cellular perturbations, disease progression, and vulnerability to reproductive and metabolic issues.This review primarily focuses ondiagnostic and prognostic biomarkers associated with PCOS, highlighting their relevance in early detection, disease stratification, and risk assessment. Therapeutic biomarkers are discussed only where they offer mechanistic or clinical insight into disease progression.Expert opinion: The combination of endocrine, metabolic, circadian, and RNA-based biomarkers offers a dynamic approach to PCOS prognostication. These biomarkers can improve the early diagnosis of high-risk patients, individual interventions, and reproductive and metabolic management. Future research should focus on validating these markers in large cohorts and developing predictive models to support clinical decision-making beyond static diagnostic criteria.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"20 1","pages":"69-86"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Admission blood glucose and neutrophil-to-lymphocyte ratio for differentiating CT-positive from CT-negative mild traumatic brain injury. 入院血糖和中性粒细胞/淋巴细胞比值鉴别ct阳性与阴性轻度颅脑损伤。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-01-13 DOI: 10.1080/17520363.2026.2615618

Marios Lampros, George A Alexiou, Solonas Symeou, Lamprini Vlachodimitropoulou, Aikaterini Zerva, Spyridon Voulgaris

{"title":"Admission blood glucose and neutrophil-to-lymphocyte ratio for differentiating CT-positive from CT-negative mild traumatic brain injury.","authors":"Marios Lampros, George A Alexiou, Solonas Symeou, Lamprini Vlachodimitropoulou, Aikaterini Zerva, Spyridon Voulgaris","doi":"10.1080/17520363.2026.2615618","DOIUrl":"10.1080/17520363.2026.2615618","url":null,"abstract":"This study aimed to assess the diagnostic utility of routine laboratory biomarkers in adults with mTBI. We conducted a prospective study of patients who were admitted to the neurosurgical department with mTBI, had admission laboratory data available, and a brain CT scan was performed. The cohort included 101 patients (mean age: 59 ± 23.14 years). Falls were the most frequent mechanism of TBI (73.2%). Subdural hematoma (SDH) was the most frequent type of intracranial injury (31.7%), followed by contusions (28.7%), and subarachnoid hemorrhage (22.7%). Patients with intracranial trauma had higher neutrophil-to- lymphocyte (NLR) ratio (p = 0.042) and higher glucose levels (p = 0.021) than patients with concussion. Additionally, patients with SDH had significantly higher NLR and glucose levels than patients with other intracranial trauma concussion. ROC analysis showed that NLR and glucose discriminated SDH from contusion with AUCs of 0.74 (95% CI: 0.59 - 0.89) and 0.80 (95% CI: 0.7-0.9), respectively. These findings require validation in larger cohorts and suggest a meaningful role of routine biomarkers in the emergency management of mTBI. However, the single-center design and modest sample size, exclusion of patients suffering from multiple injuries, diabetes or hematologic diseases may affect measured associations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"37-45"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel circRNA signatures in cervical cancer: implications for early detection and screening. 宫颈癌中新的环状rna特征：对早期检测和筛查的意义。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1080/17520363.2026.2631965

Michael Zhong, Josephine Peitz, Michelle Newman, Samiatu Yussuf, Clement A Adebamowo, Kiranpreet K Chawla, Diana N Carvajal, Amy J Plotkin, Paul N Staats, Sally N Adebamowo

{"title":"Novel circRNA signatures in cervical cancer: implications for early detection and screening.","authors":"Michael Zhong, Josephine Peitz, Michelle Newman, Samiatu Yussuf, Clement A Adebamowo, Kiranpreet K Chawla, Diana N Carvajal, Amy J Plotkin, Paul N Staats, Sally N Adebamowo","doi":"10.1080/17520363.2026.2631965","DOIUrl":"10.1080/17520363.2026.2631965","url":null,"abstract":"Introduction: Circular RNAs (circRNAs) are emerging as potential biomarkers due to their role in gene regulation. We explored whether specific circRNAs could serve as biomarkers for cervical cancer screening by distinguishing between different stages of cervical disease.Areas covered: We analyzed circRNA expression from archival formalin-fixed paraffin-embedded cervical tissues obtained from 272 women, of which 36% were benign, 33% were precancerous and 31% were cancerous. We performed differential expression analysis using DESeq2 to identify circRNAs that showed log2 fold change ≥2.Expert opinion/commentary: We identified 5790 statistically significant circRNAs that were differentially expressed between benign and cancerous cervical tissues; circ_0123115 (log2FC = 5.10, p = 1.66 × 10-55), associated with FGF12, was the most significant. Comparing benign to precancerous tissues, we found 1439 circRNAs with statistically significant differential expression, with circ_0100775 (log2FC = 2.13, p = 1.38 × 10-18), associated with TDRD3, being the most significant. Between precancerous and cancerous tissues, 4915 circRNAs were differentially expressed with statistical significance; circ_0006038 (log2FC = 4.74, p = 1.22 × 10-40), associated with STXBP6, was the most significant. In a three-way comparison, 57,749 circRNAs were differentially expressed, with circ_0106394 (p = 3.02 × 10-21), associated with USP22, being the most significant. Our study identified circRNAs with significant differential expression across benign, precancerous, and cancerous cervical tissues, demonstrating their potential role in cervical cancer progression.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"119-128"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stage-specific association of urinary C-megalin with diabetic kidney disease: a cross-sectional study in type 2 diabetes. 尿c - meggalin与糖尿病肾病的分期特异性关联：2型糖尿病的横断面研究

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1080/17520363.2025.2608945

Sagar Dholariya, Gyanendra Singh, Mehul Kaliya, Ragini Singh, Amit Sonagra, Deepak Parchwani

{"title":"Stage-specific association of urinary C-megalin with diabetic kidney disease: a cross-sectional study in type 2 diabetes.","authors":"Sagar Dholariya, Gyanendra Singh, Mehul Kaliya, Ragini Singh, Amit Sonagra, Deepak Parchwani","doi":"10.1080/17520363.2025.2608945","DOIUrl":"10.1080/17520363.2025.2608945","url":null,"abstract":"Aims: This study aimed to evaluate urinary C-megalin in relation to disease staging and diagnostic accuracy in Indian patients with type 2 diabetes mellitus (T2DM).Materials and methods: In this cross-sectional study, 325 participants were classified into No-DKD, early-DKD, and late-DKD based on kidney disease improving global outcomes (KDIGO) criteria. Urinary C-megalin was quantified by enzyme-linked immunosorbent assay (ELISA) as absolute and creatinine-normalized values. Group comparisons, correlation analyses, and multinomial logistic regression were performed to assess associations with disease stage.Results: Creatinine-normalized C-megalin excretion was higher in early-DKD compared with No-DKD (median 125.0 vs. 92.0 ng/mg Cr; p = 0.02) and independently associated with early disease [odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.03-1.55; p = 0.02). In late-DKD, absolute C-megalin levels were significantly associated with disease status (OR = 1.23, 95% CI: 1.02-1.48; p = 0.03), while normalized values lost significance. Diagnostic evaluation showed moderate accuracy for detecting early-DKD [area under curve (AUC): 0.69, 95% CI: 0.62-0.76, p = 0.001).Conclusion: Urinary C-megalin demonstrates stage-dependent diagnostic behavior in DKD, suggesting potential as a complementary marker for early tubular injury and advanced disease in high-risk diabetic populations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"5-15"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing breast cancer healthcare: the latest innovations in diagnostic biomarkers. 革新乳腺癌医疗保健：诊断生物标志物的最新创新。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-01-01 Epub Date: 2026-02-23 DOI: 10.1080/17520363.2026.2634443

Saeeda Tariq, Samia Afzal

引用次数: 0