{"title":"Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction.","authors":"Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao","doi":"10.2217/bmm-2023-0605","DOIUrl":"10.2217/bmm-2023-0605","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. <b>Methods:</b> Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. <b>Results:</b> Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0.81). <b>Conclusion:</b> Initial blood BNP and NT-proBNP levels are useful to assist in the detection of SIMD and further studies are warranted to determine the SIMD definition.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"145-155"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lipid accumulation product is a valid predictor of hepatic steatosis and nonalcoholic fatty liver disease.","authors":"Qiaoli Huang, Xuying Tan, Qiongmei Wu, Hanqing Zhao, Hangjun Chen, Xinxue Yu, Jinting Wang, Xueyi Huang, Yurong Huang, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang","doi":"10.2217/bmm-2023-0725","DOIUrl":"10.2217/bmm-2023-0725","url":null,"abstract":"<p><p><b>Aims:</b> To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate aminotransferase (AST), visceral adiposity index (VAI) and triglyceride-glucose index (TyG) as biomarkers for hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). <b>Methods:</b> LAP, ALT, AST, VAI and TyG were measured in 52 biopsy-proven NAFLD patients and 21 control subjects. Additionally, LAP was also measured in 448 ultrasound-proven NAFLD patients and 1009 control subjects. <b>Results:</b> LAP was positively associated with hepatic steatosis and inflammation in biopsy-proven NAFLD. The risk of NAFLD was positively related to LAP and TyG, but LAP showed a better area under the receiver operating characteristic curve for hepatic steatosis and NAFLD. LAP also performed well in recognizing ultrasound-proven NAFLD. <b>Conclusion:</b> LAP is an ideal biomarker of hepatic steatosis and NAFLD.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"123-135"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-02-01Epub Date: 2024-03-05DOI: 10.2217/bmm-2023-0682
Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş
{"title":"C-reactive protein to albumin ratio may predict in-hospital mortality in non-ST elevation myocardial infarction.","authors":"Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş","doi":"10.2217/bmm-2023-0682","DOIUrl":"10.2217/bmm-2023-0682","url":null,"abstract":"<p><p><b>Objective:</b> The authors investigated the value of novel inflammatory markers, systemic immune-inflammation index and C-reactive protein to albumin ratio (CAR), to predict in-hospital mortality in patients with non-ST elevation myocardial infarction (NSTEMI). <b>Materials & methods:</b> A total of 308 patients who underwent percutaneous coronary intervention because of NSTEMI were retrospectively included in the study. Killip classification, Thrombolysis in Myocardial Infarction score, SYNTAX score, and CAR and systemic immune-inflammation index values were calculated. <b>Results:</b> CAR (cutoff: 0.0864; sensitivity: 94.1%; specificity: 40.5%; p = 0.008) and Killip classification (cutoff: 2.5; sensitivity: 64.7%; specificity: 8.9%; p = 0.001) were found to be significantly higher in determining in-hospital mortality. <b>Conclusion:</b> This study revealed that CAR is an inexpensive and significant factor in predicting in-hospital mortality in patients undergoing percutaneous coronary intervention for NSTEMI.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"103-113"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations between neutrophil-to-lymphocyte/platelet-to-lymphocyte and recovery in sudden sensorineural hearing loss.","authors":"Xinmei Huang, Xupei Ni, Jun Shen, Lihua Chen, Liying Xu, Xuxia Tang","doi":"10.2217/bmm-2022-0729","DOIUrl":"10.2217/bmm-2022-0729","url":null,"abstract":"<p><p><b>Aims:</b> This study investigated the nonlinear associations between neutrophil-to-lymphocyte (NLR)/platelet-to-lymphocyte (PLR) and recovery rates in sudden sensorineural hearing loss (SSNHL). <b>Methods:</b> Total of 244 SSNHL patients were included. The primary outcome was recovery rate. <b>Results:</b> A nonlinear association was detected between NLR and recovery rate using the LOWESS method, with a knot of 3. Patients with NLR ≥3 had a higher recovery rate than NLR <3. Using the linear-spline function, NLR was significantly associated with high recovery rate when NLR was <3. However, when NLR was ≥3, this association became nonsignificant. The trend test showed a similar result. PLR was not associated with recovery rate. <b>Conclusion:</b> The association between NLR and recovery rate is nonlinear, with a knot of around three. PLR is not associated with recovery rate.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"115-122"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan
{"title":"Relationship between platelet/hemoglobin and radial thrombus in patients with coronary angiography via radial access.","authors":"Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan","doi":"10.2217/bmm-2023-0394","DOIUrl":"https://doi.org/10.2217/bmm-2023-0394","url":null,"abstract":"<p><p><b>Aim:</b> To predict the development of radial artery thrombus (RAT) in patients with radial approach coronary angiography of platelet-to-hemoglobin ratio (PHR). <b>Materials & methods:</b> This study was designed to evaluate the relationship between RAT and PHR. A total of 1156 patients who had coronary angiography via the transradial approach between 2021 and 2022 in the authors' center were included in the study. <b>Results:</b> Radial thrombus was detected in 52 (4.5%) patients. PHR was higher in the group with thrombus and was statistically significant. In the regression model, PHR was an independent predictor of the development of radial thrombus (p = 0.007). <b>Conclusion:</b> High PHR may be an independent predictor of the development of radial thrombus.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salivary cysteine levels as a potential biochemical indicator of oral cancer risk in tobacco consumers.","authors":"Ravina Vats, Pooja Yadav, Afsareen Bano, Sapna Wadhwa, Anjali Narwal, Rashmi Bhardwaj","doi":"10.1080/17520363.2024.2403327","DOIUrl":"10.1080/17520363.2024.2403327","url":null,"abstract":"<p><p><b>Aim:</b> Oral cancer is the leading cause of mortality, with a survival rate of less than 5 years, and is predominantly influenced by tobacco mutagens. Invasive diagnostic methods hinder early detection of oral cancer biomarkers. The present study performed salivary biochemical analysis for early oral cancer screening in tobacco consumers.<b>Materials & methods:</b> Three study groups included healthy controls (n = 25), tobacco users (n = 25) and oral cancer patients (n = 25). Salivary total protein, amylase, TNF-α and amino acid levels were evaluated using enzymatic tests, Enzyme linked Immunosorbent Assay (ELISA) and High-Performance Liquid Chromatography (HPLC).<b>Results:</b> Compared with healthy controls, salivary total protein and TNF-α levels were significantly (<i>p</i> = 0.04) higher in oral cancer patients. Salivary amylase levels were significantly lower in tobacco smokers (<i>p</i> = 0.02) and higher in oral cancer patients (<i>p</i> = 0.01). Interestingly, the amino acid cysteine concentration was significantly higher (<i>p</i> = 0.02) in tobacco consumers (62.5 ± 10) than in healthy controls (116.1 ± 28).<b>Conclusion:</b> In high-risk populations, such as tobacco users, salivary biochemical analysis can serve as a promising noninvasive diagnostic method for early oral cancer screening. As a salivary biomarker, the amino acid cysteine exhibits potential as a means of detecting the progression of oral cancer in individuals who consume tobacco.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"877-888"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-07-31DOI: 10.1080/17520363.2024.2380246
Yin Jin, Xingchen Ye
{"title":"Prognostic value of C-reactive protein in patients with glioma: a meta-analysis.","authors":"Yin Jin, Xingchen Ye","doi":"10.1080/17520363.2024.2380246","DOIUrl":"10.1080/17520363.2024.2380246","url":null,"abstract":"<p><p><b>Background:</b> In this meta-analysis, we investigated C-reactive protein (CRP)'s role in glioma prognosis prediction.<b>Methods:</b> We conducted the current meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews and meta-analyses. An analysis of the prognostic effect of CRP on glioma was conducted using combined hazard ratios (HRs) and 95% confidence intervals (CIs).<b>Results:</b> The combined data suggested that a higher CRP level was markedly related to poor overall survival in glioma (hazard ratio: 1.73; 95% CI: 1.22-2.46; <i>p</i> = 0.002).<b>Conclusion:</b> According to results in the present meta-analysis, elevated CRP levels were significantly related to inferior overall survival in glioma.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"629-637"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-08-13DOI: 10.1080/17520363.2024.2352421
Fatih Kus, Deniz Can Guven, Hasan Cagri Yildirim, Elvin Chalabiyev, Arif Akyildiz, Omer D Tatar, Yigit Berk Sahin, Serez İleri, Ece Karaca, Neyran Kertmen, Zafer Arık
{"title":"KELIM score predicts outcome in patients with platinum-resistant/refractory recurrent ovarian cancer.","authors":"Fatih Kus, Deniz Can Guven, Hasan Cagri Yildirim, Elvin Chalabiyev, Arif Akyildiz, Omer D Tatar, Yigit Berk Sahin, Serez İleri, Ece Karaca, Neyran Kertmen, Zafer Arık","doi":"10.1080/17520363.2024.2352421","DOIUrl":"10.1080/17520363.2024.2352421","url":null,"abstract":"","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"511"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictors of 2-year mortality in geriatric patients hospitalized with COVID-19 in Türkiye: a retrospective cohort study.","authors":"Bahar Bektan Kanat, Gulru Ulugerger Avci, Osman Faruk Bayramlar, Veysel Suzan, Gunay Can, Ilker Inanc Balkan, Sermin Borekci, Bora Korkmazer, Yalim Dikmen, Gokhan Aygun, Deniz Suna Erdincler, Hakan Yavuzer, Alper Doventas","doi":"10.1080/17520363.2024.2352416","DOIUrl":"10.1080/17520363.2024.2352416","url":null,"abstract":"<p><p><b>Aim:</b> To reveal factors affecting 2-year mortality in geriatric patients hospitalized with COVID-19.<b>Methods:</b> Demographic characteristics, clinical and laboratory data, thorax computed tomography (CT) images, second-year survival status, and causes of death were analyzed.<b>Results:</b> The 2-year post-discharge mortality rate of 605 patients was 21.9%. Mean age of patients in the deceased group was 76.8 ± 8.1 years, which was shorter than the life expectancy at birth in Türkiye. Older age (≥85), delirium, some co-morbidities, and atypical thorax CT involvement were associated with a significant increase in 2-year mortality (p < 0.05).<b>Conclusion:</b> This is the first study to evaluate factors associated with 2-year mortality in older COVID-19 patients. Identifying risk factors for long-term mortality in geriatric COVID-19 patients is important.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"555-565"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-10-29DOI: 10.1080/17520363.2024.2415284
Ozan Tezen, Mert İlker Hayıroğlu, Levent Pay, Ahmet Çağdaş Yumurtaş, Kıvanç Keskin, Tuğba Çetin, Şeyda Dereli, Hikmet Kadığoğlu, Furkan Fatih Yücedağ, Ertan Arter, Şennur Ünal Dayı
{"title":"The role of systemic immune-inflammatory index in predicting contrast-induced nephropathy in non-ST-segment elevation myocardial infarction cases.","authors":"Ozan Tezen, Mert İlker Hayıroğlu, Levent Pay, Ahmet Çağdaş Yumurtaş, Kıvanç Keskin, Tuğba Çetin, Şeyda Dereli, Hikmet Kadığoğlu, Furkan Fatih Yücedağ, Ertan Arter, Şennur Ünal Dayı","doi":"10.1080/17520363.2024.2415284","DOIUrl":"10.1080/17520363.2024.2415284","url":null,"abstract":"<p><p><b>Aim:</b> Systemic immune-inflammation index (SII) is obtained by multiplying the platelets by the ratio of neutrophils to lymphocytes. We aimed to examine the relationship between contrast induced nephropathy (CIN) development and SII in non-ST-segment elevation myocardial infarction (NSTEMI) patients.<b>Methods:</b> 1124 NSTEMI patients included and divided into two groups according to the development of CIN. The relationship between SII and CIN development was examined.<b>Results:</b> Among two groups, significant differences were observed in terms of age, chronic renal failure, presence of critical stenoses in the LAD, SII and C-reactive protein (CRP). It was calculated that a value of 709 and above for SII had a predictive power with 74% sensitivity and 74% specificity for CIN.<b>Conclusion:</b> SII has the potential to predict the development of CIN in NSTEMI patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"937-944"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}