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Exploring the correlation between homocysteine, red blood cell folate and MTHFRC677T genotypes with female infertility. 探讨同型半胱氨酸、红细胞叶酸和 MTHFRC677T 基因型与女性不孕的相关性。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394386
Xueyun You,Zhaozhen Zhang,Yonghua Xu,Bicheng Yang,Shuhui Huang,Yongyi Zou,Feng Zhao,Chuanxin Feng,Haorui Lao,Huizhen Yuan,Yanqiu Liu,Min Wu
{"title":"Exploring the correlation between homocysteine, red blood cell folate and MTHFRC677T genotypes with female infertility.","authors":"Xueyun You,Zhaozhen Zhang,Yonghua Xu,Bicheng Yang,Shuhui Huang,Yongyi Zou,Feng Zhao,Chuanxin Feng,Haorui Lao,Huizhen Yuan,Yanqiu Liu,Min Wu","doi":"10.1080/17520363.2024.2394386","DOIUrl":"https://doi.org/10.1080/17520363.2024.2394386","url":null,"abstract":"Aim: To investigate the association between serum homocysteine (HCY) levels, red blood cell folate (RCF) levels, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and infertility.Materials & methods: Serum HCY and RCF levels and C677T polymorphism of MTHFR gene were analyzed in 149 infertile patients and 223 women of normal reproductive age with healthy childbirth history.Results: The HCY level of MTHFR C677T TT genotype infertility patients was higher than that of women of normal reproductive age, while the RCF level was not significantly different between the two groups.Conclusion: Serum HCY levels increased in infertility patients, and the MTHFR C677T TT genotype in childbearing-aged women are associated with a higher risk of infertility. The results showed that HCY level and MTHFR C677T genotype were closely related to infertility.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"5 1","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure. 心力衰竭住院期间发现的红细胞分布宽度增加的长期影响。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2395237
Otto Mayer,Jan Bruthans,Josef Jirák,Jan Filipovský
{"title":"The long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure.","authors":"Otto Mayer,Jan Bruthans,Josef Jirák,Jan Filipovský","doi":"10.1080/17520363.2024.2395237","DOIUrl":"https://doi.org/10.1080/17520363.2024.2395237","url":null,"abstract":"Aim: We determined the long-term role of increased RDW (red blood cell distribution width) detected during cardiac decompensation.Methods: We followed 3697 patients [mean age 71.4 years (±SD 10.1), 59.1% males] hospitalized for acute heart failure (HF) and assessed the five-year all-cause mortality risk associated with tertiles of RDW.Results: Patients with RDW in the top tertile showed roughly twofold higher 5-year mortality risk than those in the bottom tertile. The association remained significant not only after adjustments for potential covariates but even if we excluded patients who deceased during the first year of follow-up [HRR 1.76 (95% CIs:1.42-2.18), p < 0.0001].Conclusion: The high degree of anisocytosis represents an independent predictor of poor prognosis in HF patients, even long-term after an acute manifestation.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"6 1","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions. 人类癌前病变和癌症宫颈病变中的 RAP1-GTPase 免疫染色发生了改变。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394384
Paula Cristina de Vasconcelos,Tulio Resende Freitas,Lara Verônica de Araújo Lopes,Larissa Rodrigues Peixoto,Marcelo Pascoal Xavier,Anna Carolina Cançado Figueiredo,Karolina Lopes Dias,Jaqueline Germano de Oliveira,Paulo Guilherme de Oliveira Salles,Annamaria Ravaro Vago,Adriano de Paula Sabino,Maria Gabrielle de Lima Rocha
{"title":"RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions.","authors":"Paula Cristina de Vasconcelos,Tulio Resende Freitas,Lara Verônica de Araújo Lopes,Larissa Rodrigues Peixoto,Marcelo Pascoal Xavier,Anna Carolina Cançado Figueiredo,Karolina Lopes Dias,Jaqueline Germano de Oliveira,Paulo Guilherme de Oliveira Salles,Annamaria Ravaro Vago,Adriano de Paula Sabino,Maria Gabrielle de Lima Rocha","doi":"10.1080/17520363.2024.2394384","DOIUrl":"https://doi.org/10.1080/17520363.2024.2394384","url":null,"abstract":"Aim: This study investigated RAP1 immunostaining variation in different cell types during CC progression.Methods: Paraffin-embedded cervical tissues from 101 patients were categorized into control, pre-neoplastic and neoplastic groups. RAP1 immunolocalization, HPV detection and genotyping were performed. A semiquantitative immunoreactive score was employed to compare labeling intensity, cellular localization, nuclear labeling, percentage and distribution of reactive cells.Results: 73% (72/99) of cervical specimens were HPV+. RAP1 was localized in the nucleus and cytoplasm of all samples. Cytoplasmic RAP1 immunoscore was higher than nuclear score in all CC groups. RAP1 intensity increased with lesion severity. SCC samples exhibited predominantly intense RAP1 immunostaining.Conclusion: RAP1 is an efficient biomarker for detecting invasive CC lesions but has limited utility in distinguishing SCC grades.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"12 1","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial infarction. 确诊为心肌梗死患者的 HbA1c/C 肽水平与短期死亡率之间的关系。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-08-17 Epub Date: 2024-08-05 DOI: 10.1080/17520363.2024.2380248
Sefa Erdi Ömür, Emin Koyun, Gökhan Cabri, Çağri Zorlu
{"title":"The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial infarction.","authors":"Sefa Erdi Ömür, Emin Koyun, Gökhan Cabri, Çağri Zorlu","doi":"10.1080/17520363.2024.2380248","DOIUrl":"10.1080/17520363.2024.2380248","url":null,"abstract":"<p><p><b>Introduction:</b> In this study, we aimed to investigate the effect of HbA1C/C-peptide ratio on short-term mortality (this period is defined as 30 days after diagnosis) in the patients with myocardial infarction.<b>Materials & Methods:</b> Around 3245 patients who were admitted due to ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction underwent primary percutaneous coronary intervention between October 2020 and 2024 were included in this study.<b>Results:</b> In the receiver operating characteristic analysis, the predictive power of the HCR score for mortality in ST-elevation myocardial infarction patients was determined to be 83% sensitivity and 81% specificity. In non-ST-elevation myocardial infarction, this was determined to be 78% sensitivity and 75% specificity.<b>Conclusion:</b> The HbA1C/C-peptide ratio score can predict poor clinical outcomes early, reducing mortality and morbidity in patients with myocardial infarction.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"665-673"},"PeriodicalIF":1.9,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of miR-200 family in non-small cell lung cancer: a meta-analysis miR-200 家族在非小细胞肺癌中的诊断价值：一项荟萃分析
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-16 DOI: 10.2217/bmm-2024-0087
Zhen Ling, Lichang Yang
{"title":"Diagnostic value of miR-200 family in non-small cell lung cancer: a meta-analysis","authors":"Zhen Ling, Lichang Yang","doi":"10.2217/bmm-2024-0087","DOIUrl":"https://doi.org/10.2217/bmm-2024-0087","url":null,"abstract":"<p><b>Aim:</b> To investigate the diagnostic potential of the miR-200 family for early detection in non-small cell lung cancer (NSCLC). <b>Materials &amp; methods:</b> A systematic search was conducted of PubMed, Embase and Web of Science databases to identify studies of the miR-200 family in NSCLC. Sixteen studies meeting the inclusion criteria were included in the analysis with a total of 20 cohorts. <b>Results:</b> The combined sensitivity and specificity reached 73% and 85%, with an area under the curve of 0.83. Notably, miR-200b introduced heterogeneity. Subgroup analysis highlighted miR-200a and miR-141 as more sensitive, while blood-derived miRNAs showed slightly lower accuracy. <b>Conclusion:</b> The miR-200 family, predominantly assessed in blood, exhibits significant diagnostic potential for NSCLC, especially in distinguishing it from benign diseases.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"43 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141061640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum vitamin D, hemoglobin A1c and vitamin B12 levels in patients with gingivitis and periodontitis stages 牙龈炎和牙周炎阶段患者的血清维生素 D、血红蛋白 A1c 和维生素 B12 水平
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-15 DOI: 10.1080/17520363.2024.2342236
Selcen Ozcan Bulut, Deniz Noyun, Sebnem Dirikan İpci, Gokser Cakar
{"title":"Serum vitamin D, hemoglobin A1c and vitamin B12 levels in patients with gingivitis and periodontitis stages","authors":"Selcen Ozcan Bulut, Deniz Noyun, Sebnem Dirikan İpci, Gokser Cakar","doi":"10.1080/17520363.2024.2342236","DOIUrl":"https://doi.org/10.1080/17520363.2024.2342236","url":null,"abstract":"<p><b>Aim:</b> To compare the serum vitamin D, hemoglobin A1c (HbA1c) and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification. <b>Materials &amp; methods:</b> A total of 606 patients were included in the study who were diagnosed with gingivitis and stage I–IV periodontitis. Patients were divided into groups based on disease stage, and the HbA1c, vitamin D and B12 levels of the patients were compared and analyzed. <b>Result:</b> The highest HbA1c level and the lowest vitamin D level were seen in stage III–IV periodontitis. The highest vitamin D and B12 levels were seen in the gingivitis group. <b>Conclusion:</b> Serum HbA1c, vitamin D and B12 levels might vary depending on the presence or severity of periodontitis.</p><p><b>Clinical Trial Registration:</b> NCT05745779 (This study was registered and approved by www.clinicaltrials.gov)</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"1 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C-reactive protein to albumin ratio and radial artery thrombosis post transradial angiography 经桡动脉血管造影术后 C 反应蛋白与白蛋白比率和桡动脉血栓形成
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-15 DOI: 10.1080/17520363.2024.2345578
Serkan Bulguroglu, Yunus Calapkulu, Ural Koc, Mehmet Erdogan, Zehra Gölbası
{"title":"C-reactive protein to albumin ratio and radial artery thrombosis post transradial angiography","authors":"Serkan Bulguroglu, Yunus Calapkulu, Ural Koc, Mehmet Erdogan, Zehra Gölbası","doi":"10.1080/17520363.2024.2345578","DOIUrl":"https://doi.org/10.1080/17520363.2024.2345578","url":null,"abstract":"<p><b>Aim:</b> The aim is to evaluate the relationship between C-reactive protein (CRP) to albumin ratio (CAR) and radial artery thrombosis in patients undergoing radial angiography. <b>Patients &amp; methods:</b> We prospectively included 261 consecutive patients undergoing radial angiography, assessing radial artery diameter and thrombosis presence. <b>Results:</b> The CRP values were significantly higher in radial artery thrombosis group compared with group without thrombosis (13.01 vs. 4.33 mg/l, p &lt; 0.001, respectively). Also CAR was statistically significantly different between the group with thrombosis and the group without thrombosis (0.102 vs. 0.349, p &lt; 0.001). <b>Conclusion:</b> Our study is the first to assess CAR in radial thrombus development post-procedure in patients undergoing radial angiography. CAR can be useful in determining radial artery thrombosis after the coronary angiography.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"66 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting cerebral infarction in tuberculous meningitis and its prognostic significance 结核性脑膜炎脑梗塞的预测及其预后意义
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-15 DOI: 10.1080/17520363.2024.2347194
Asha Aggrohia, Vikas Bhatia, Atul Saroch, Ashok Kumar Pannu
{"title":"Predicting cerebral infarction in tuberculous meningitis and its prognostic significance","authors":"Asha Aggrohia, Vikas Bhatia, Atul Saroch, Ashok Kumar Pannu","doi":"10.1080/17520363.2024.2347194","DOIUrl":"https://doi.org/10.1080/17520363.2024.2347194","url":null,"abstract":"<p><b>Aim:</b> Tuberculous meningitis (TBM) often causes cerebral infarction, but its predictive factors are not well understood. <b>Methods:</b> Patients aged ≥13 years admitted with TBM were enrolled prospectively. Cerebral infarction was diagnosed using magnetic resonance imaging. <b>Results:</b> Of 186 patients, 80 (43%) had infarction. Most infarctions were multiple and located in the cortical areas, basal ganglia and subcortical regions. Independent predictors of infarction at admission included high blood pressure, short illness duration, low Glasgow coma scale and hydrocephalus. Neuroimaging inflammation signs, cerebrospinal fluid analysis abnormalities and pre-existing cardiovascular risks did not predict infarction. In-hospital mortality was higher in TBM with infarction, particularly in those with advanced TBM (stage 3). <b>Conclusion:</b> Baseline parameters of raised intracranial pressure predict cerebral infarction in TBM.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"122 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of inflammation markers in occurrence of radial artery occlusion 炎症标志物在桡动脉闭塞发生中的作用
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-15 DOI: 10.1080/17520363.2024.2345582
Saadet Demirtas Inci, Huseyin Gunduz, Yasemin Gunduz
{"title":"The role of inflammation markers in occurrence of radial artery occlusion","authors":"Saadet Demirtas Inci, Huseyin Gunduz, Yasemin Gunduz","doi":"10.1080/17520363.2024.2345582","DOIUrl":"https://doi.org/10.1080/17520363.2024.2345582","url":null,"abstract":"<p><b>Aim:</b> Radial artery occlusion (RAO) is a major complication of catheterization via transradial access (TRA). Our aim is to reveal the ability of high-sensitive C-reactive protein (hs-CRP) and complete blood count (CBC) components, which are inflammation markers, to predict RAO. <b>Methods:</b> Patients were divided into two groups: 103 with RAO and 300 without RAO. The relationship between CRP, CBC components and RAO was evaluated. <b>Results:</b> A significant increase in hs-CRP, monocyte, platelet (PLT), platelet distribution width (PDW) and plateletcrit values was observed after TRA, and only the increase in PDW, PLT and hs-CRP was found to be independent determinants in regression analysis. <b>Conclusion:</b> High PDW and PLT and increased hs-CRP levels are new independent determinants of the development of RAO.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"32 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of PD-L1 expression in patients with anal cancer: a meta-analysis 肛门癌患者 PD-L1 表达的预后价值：一项荟萃分析
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-05-03 DOI: 10.2217/bmm-2023-0727
Siqi Gong, Jiafeng Song
{"title":"Prognostic value of PD-L1 expression in patients with anal cancer: a meta-analysis","authors":"Siqi Gong, Jiafeng Song","doi":"10.2217/bmm-2023-0727","DOIUrl":"https://doi.org/10.2217/bmm-2023-0727","url":null,"abstract":"<p><b>Background:</b> The present meta-analysis was performed to evaluate the prognostic and clinicopathological significance of PD-L1 in anal cancer (AC). <b>Methods:</b> Hazard ratios (HRs) and 95% CIs regarding overall survival (OS) and progression-free survival (PFS) were calculated based on PD-L1 levels. <b>Results:</b> According to the combined data, PD-L1 showed no significant relationship with OS (HR = 0.76; 95% CI = 0.35–1.67; p = 0.502) or PFS (HR = 0.88; 95% CI = 0.35–2.33; p = 0.789) in patients with AC. Based on subgroup analysis, PD-L1 overexpression significantly predicted prolonged OS (HR = 0.38; 95% CI = 0.17–0.84; p = 0.017) in tumor node metastasis stages I–III and inferior PFS (HR = 2.73; 95% CI = 1.32–5.65; p = 0.007) in patients with stage I–IV AC. <b>Conclusion:</b> PD-L1 level assessed by immunohistochemistry did not significantly predict survival outcomes in AC cases.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"4 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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