Biomarkers in medicine最新文献_第8页

Exploring the potential of D-dimer as a diagnostic and prognostic biomarker for acute pericarditis. 探讨d -二聚体作为急性心包炎诊断和预后生物标志物的潜力。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-28 DOI: 10.1080/17520363.2024.2448021

George Lazaros, Emilia Lazarou, Charalambos Vlachopoulos, Costas Tsioufis

引用次数: 0

Triglyceride-glucose index as a biomarker to differentiate stroke etiologic subtypes: a hospital-based cross-sectional study. 甘油三酯-葡萄糖指数作为区分脑卒中病因亚型的生物标志物：一项基于医院的横断面研究

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1080/17520363.2024.2443382

Nizar Daoussi, Imen Zemni, Narjes Gouta, Yasmine Saad, Rihab Ben Dhia, Mariem Mhiri, Asma Belghith-Sriha, Mahbouba Frih-Ayed

{"title":"Triglyceride-glucose index as a biomarker to differentiate stroke etiologic subtypes: a hospital-based cross-sectional study.","authors":"Nizar Daoussi, Imen Zemni, Narjes Gouta, Yasmine Saad, Rihab Ben Dhia, Mariem Mhiri, Asma Belghith-Sriha, Mahbouba Frih-Ayed","doi":"10.1080/17520363.2024.2443382","DOIUrl":"10.1080/17520363.2024.2443382","url":null,"abstract":"Background: Accurate distinction between stroke etiologic subtypes is critical for physicians to provide tailored treatment. The triglyceride-glucose (TyG) index, a marker of insulin resistance, has been associated with stroke risk but its role in distinguishing stroke etiologic subtypes remains unclear. We aimed to assess the TyG index's ability to differentiate cardioembolic (CE) from non-cardioembolic (NCE) strokes.Methods: We studied 320 consecutive stroke patients in a cross-sectional analysis. Binary logistic regression was performed to analyze the association between the TyG index and the studied stroke subtypes. Receiver operating characteristic (ROC) curve analysis identified the optimal TyG index cutoff for CE vs. NCE differentiation.Results: TyG index correlated independently with NCE subtype (OR = 2.38; 95% CI = 1.52-3.73; p < 0.001). Logistic regression revealed increasing NCE stroke risk with higher TyG index quartiles. The ROC curve yielded an AUC of 0.636 (95% CI = 0.565-0.707; p < 0.001), with a cutoff of 8.8 (sensitivity = 68.8%, specificity = 57%).Conclusion: The TyG index can be a useful biomarker in the differentiation between CE and NCE strokes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 1","pages":"23-29"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematological markers as prognostic indicators in multiple sclerosis progression. 血液学指标作为多发性硬化进展的预后指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1080/17520363.2024.2441106

Maryam Poursadeghfard, Samin Shiati, Mohammad Saied Salehi, Aryan Khani, Soheil Vafaeian, Mahnaz Bayat, Etrat Hooshmandi

引用次数: 0

Torquetenovirus in bronchoalveolar lavage fluid for early detection of pulmonary infections in immunocompromised hosts. 支气管肺泡灌洗液中torquetenvirus对免疫功能低下宿主肺部感染的早期检测。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1080/17520363.2025.2453416

Ashok Kumar Pannu

引用次数: 0

Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis. 严重主动脉瓣狭窄的 TAVI 患者中 N-乙酰葡糖苷酶和肾损伤分子-1 的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1080/17520363.2024.2429366

Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer

{"title":"Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis.","authors":"Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer","doi":"10.1080/17520363.2024.2429366","DOIUrl":"10.1080/17520363.2024.2429366","url":null,"abstract":"Aim: Cardiorenal syndrome (CRS) is common in severe aortic stenosis (AS). Previous studies revealed N-Acetylglucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for CRS. The study aimed to investigate the prognostic capability of NAG, KIM-1, NT-proBNP in severe AS before TAVI.Materials & methods: Plasma and urine samples were collected from 151 participants before TAVI. Long-term follow-up (median follow-up time 31 months) was conducted to assess all-cause mortality and a composite endpoint of mortality and congestive heart failure.Results: NT-proBNP was significantly elevated in classical low-flow, low-gradient AS compared to other severe AS phenotypes (p < 0.01), unlike NAG and KIM-1 (each p = n.s.). During follow-up, 40 patients (26.5%) died, and 58 patients (38.4%) reached the composite endpoint. Elevated baseline levels of NAG and KIM-1 were associated with increased risk of all-cause mortality in Kaplan-Meier analysis, like NT-proBNP (each p<0.05). NAG and STS-Score were revealed as significant predictors for all-cause mortality in multivariable COX-regression analysis (each p<0.05), unlike NT-proBNP, KIM-1, eGFR, and clinical parameters (each p=n.s.).Conclusion: Baseline NAG and, to a lesser degree, KIM-1 and NT-proBNP provide significant predictive value for all-cause mortality in patients with severe AS before TAVI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1075-1085"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMB is associated with the prognosis of egfr-mutated non-small cell lung cancer in Xuanwei, China. 在宣威，TMB与egfr突变的非小细胞肺癌的预后相关。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1080/17520363.2024.2432306

Han Wang, Junrui Ma, Jiagui Lu, Yang Wang, Binli Zhang, Hushan Zhang, Hao Peng

引用次数: 0

Correction. 修正。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1080/17520363.2024.2437843

引用次数: 0

Update prognostic potency of surfactant protein D (SP-D) in the COVID-19 landscape: an In-depth meta-analytical exploration. “表面活性剂蛋白D （SP-D）在COVID-19领域的最新预后效力：一项深入的荟萃分析探索”。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 DOI: 10.1080/17520363.2024.2432325

Mohammad-Navid Bastani, Shahram Jalilian, Seyed Sobhan Bahreiny, Manoochehr Makvandi, Mojtaba Aghaei, Zahra Mansouri, Negin Karamali, Tannaz Sakhavarz, Mahdi Amraei, Elnaz Harooni

{"title":"Update prognostic potency of surfactant protein D (SP-D) in the COVID-19 landscape: an In-depth meta-analytical exploration.","authors":"Mohammad-Navid Bastani, Shahram Jalilian, Seyed Sobhan Bahreiny, Manoochehr Makvandi, Mojtaba Aghaei, Zahra Mansouri, Negin Karamali, Tannaz Sakhavarz, Mahdi Amraei, Elnaz Harooni","doi":"10.1080/17520363.2024.2432325","DOIUrl":"10.1080/17520363.2024.2432325","url":null,"abstract":"Introduction: Surfactant Protein D (SP-D), a key component of the innate immune system, has attracted significant interest for its potential role in the pathophysiology and prognosis of COVID-19. This systematic review and meta-analysis aim to clarify the prognostic importance of SP-D levels in COVID-19 patients.Methods: A comprehensive literature search was conducted using PubMed, Web of Science, Cochrane Library, Scopus, EMBASE, and Google Scholar, covering studies published from January 2000 to January 2024. The inclusion criteria focused on studies measuring SP-D levels in the serum or plasma of COVID-19 patients, comparing severe and non-severe cases. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model to assess overall effect sizes. Meta-regressions and subgroup analyses were performed to identify potential sources of heterogeneity, including patient age, assay techniques, and gender ratio.Results: The meta-analysis incorporated data from nine studies involving 5,410 COVID-19 patients. Elevated SP-D levels were significantly correlated with increased disease severity, yielding an SMD of 0.642 (95% CI: 0.314 to 0.870; p = 0.012).Conclusion: This meta-analysis confirms the prognostic significance of SP-D in the context of COVID-19. Elevated SP-D levels are associated with severe disease outcomes, highlighting its potential as a prognostic biomarker.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1135-1148"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of CK-MB on the curative effect of urokinase combined with LMWH calcium in AMI. CK-MB对尿激酶联合 LMWH钙治疗急性心肌梗死疗效的预测价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-24 DOI: 10.1080/17520363.2024.2429367

Hongbin Tang, Yong Liu, Yabing Yu, Jun Zhou, Jiaomei Yang

{"title":"The predictive value of CK-MB on the curative effect of urokinase combined with LMWH calcium in AMI.","authors":"Hongbin Tang, Yong Liu, Yabing Yu, Jun Zhou, Jiaomei Yang","doi":"10.1080/17520363.2024.2429367","DOIUrl":"10.1080/17520363.2024.2429367","url":null,"abstract":"Objective: This study investigates the predictive value of CK-MB in treating acute myocardial infarction (AMI) with urokinase combined with low molecular weight heparin (LMWH) calcium.Methods: AMI patients treated at our hospital from April 2020 to August 2022 were included in this prospective, multi-center cohort study. Patients were randomly assigned to a urokinase group or a combined treatment group (urokinase plus LMWH). CK-MB levels were measured using ELISA, and adverse reactions were recorded. The accuracy of CK-MB as a predictor was evaluated via ROC curve analysis and AUC.Results: Before treatment, CK-MB levels were similar in both groups (p > 0.05). Post-treatment, levels were significantly lower in the combined group (p < 0.05). The combined group had a higher proportion of mild CK-MB elevation and lower moderate/severe elevations (p < 0.05). Adverse reaction rates were similar (p > 0.05). The combined treatment group showed higher effectiveness (p < 0.05), with better sensitivity (94%) and specificity (82%) than the urokinase group (sensitivity 89%, specificity 78%).Conclusion: CK-MB is a valuable predictor for evaluating the efficacy of urokinase plus LMWH in AMI treatment, offering advantages in reducing CK-MB levels and improving outcomes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1087-1092"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM35B as a novel biomarker for diagnosing gliomas. TMEM35B 作为诊断胶质瘤的新型生物标记物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1080/17520363.2024.2431480

Gongbo Liang, Xuwen Lai, Guangning Yan, Wenyuan He, Longjun Su, Jinxia Luo, Zhuocai Wang

引用次数: 0