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Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review. 皮肤病中的长非编码 RNA MALAT1：综述。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-07-09 DOI: 10.1080/17520363.2024.2369044
Dayanara Ruiz-Ojeda, Carlos A Guzmán-Martín, Rafael Bojalil, Ximena F Balderas, Iris S Paredes-González, Javier González-Ramírez, Enrique Torres-Rasgado, Adrián Hernández-DíazCouder, Rashidi Springall, Fausto Sánchez-Muñoz
{"title":"Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review.","authors":"Dayanara Ruiz-Ojeda, Carlos A Guzmán-Martín, Rafael Bojalil, Ximena F Balderas, Iris S Paredes-González, Javier González-Ramírez, Enrique Torres-Rasgado, Adrián Hernández-DíazCouder, Rashidi Springall, Fausto Sánchez-Muñoz","doi":"10.1080/17520363.2024.2369044","DOIUrl":"10.1080/17520363.2024.2369044","url":null,"abstract":"<p><p>Dermatologic disorders, affecting the integumentary system, involve diverse molecular mechanisms such as cell proliferation, apoptosis, inflammation and immune responses. Long noncoding RNAs, particularly Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1), are crucial regulators of gene expression. MALAT1 influences inflammatory responses, immune cell function and signaling pathways, impacting various physiological and pathological processes, including dermatologic disorders. Dysregulation of MALAT1 is observed in skin conditions like psoriasis, atopic dermatitis and systemic lupus erythematosus. However, its precise role remains unclear. This review consolidates knowledge on MALAT1's impact on skin biology and pathology, emphasizing its potential diagnostic and therapeutic implications in dermatologic conditions.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"853-867"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study. 分析恶性肿瘤的静脉血栓栓塞风险：血栓弹力图和凝血因子研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1080/17520363.2024.2342239
Wang Xue-Xing, Chu Jie, Chen Chun-Mei, He Yuan, Wei Chun-Mei
{"title":"Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study.","authors":"Wang Xue-Xing, Chu Jie, Chen Chun-Mei, He Yuan, Wei Chun-Mei","doi":"10.1080/17520363.2024.2342239","DOIUrl":"10.1080/17520363.2024.2342239","url":null,"abstract":"<p><p><b>Aim:</b> This retrospective clinical study was designed to examine the predictive value of thromboelastography (TEG) combined with coagulation function for venous thromboembolism (VTE) in hospitalized patients with cancer. <b>Materials & methods:</b> Among 215 patients admitted between May 2020 and January 2022, 39 (18.14%) were diagnosed with VTE during hospitalization. <b>Results:</b> Significant differences were found in D-dimer, ATIII and TEG parameters (maximum amplitude and coagulation index) between VTE-positive and VTE-negative patients (p < 0.05). Multivariate analysis revealed tumor node metastasis stage, concomitant infection, smoking history and D-dimer as independently associated with VTE. The constructed model and D-dimer areas under the curve were 0.809 and 0.764, respectively. <b>Conclusion:</b> TEG parameters were not significantly predictive indicators for VTE, with D-dimer remaining a key predictor.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 8","pages":"373-383"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of serum albumin in heart failure patients with cardiac resynchronization therapy. 接受心脏再同步化治疗的心力衰竭患者血清白蛋白的预后价值。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2347200
Levent Pay, Ahmet Çağdaş Yumurtaş, Ozan Tezen, Tuğba Çetin, Semih Eren, Tufan Çınar, Mert İlker Hayıroğlu
{"title":"Prognostic value of serum albumin in heart failure patients with cardiac resynchronization therapy.","authors":"Levent Pay, Ahmet Çağdaş Yumurtaş, Ozan Tezen, Tuğba Çetin, Semih Eren, Tufan Çınar, Mert İlker Hayıroğlu","doi":"10.1080/17520363.2024.2347200","DOIUrl":"10.1080/17520363.2024.2347200","url":null,"abstract":"<p><p><b>Aim:</b> There is a lack of data about the association between admission serum albumin levels and long-term mortality in heart failure (HF) patients with cardiac resynchronization therapy defibrillators (CRT-D). We aim to investigate this connection in HF patients with CRT-D. <b>Methods:</b> The study population consisted of 477 HF patients with CRT-D. The cohort was divided into three groups according to albumin values, and the relationship between these groups and long-term mortality were evaluated. <b>Results:</b> Long-term all-cause mortality (HR: 3.32, 95% CI: 2.12-6.84), appropriate (HR: 4.44, 95% CI: 2.44-8.06) and inappropriate (HR: 2.95, 95% CI: 1.88-6.02) shocks were higher in the low albumin group. <b>Conclusion:</b> Low albumin levels are associated with the long-term mortality and appropriate shock treatment in HF patients with CRT-D.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 8","pages":"363-371"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic role of systemic immune-inflammation index versus other cardiac markers in acute myocarditis in young adults. 全身免疫炎症指数与其他心脏标记物在青壮年急性心肌炎中的预后作用。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-25 DOI: 10.1080/17520363.2024.2403321
Ilke Erbay, Ugur Kokturk, Naile Eris Gudul, Ahmet Avci
{"title":"Prognostic role of systemic immune-inflammation index versus other cardiac markers in acute myocarditis in young adults.","authors":"Ilke Erbay, Ugur Kokturk, Naile Eris Gudul, Ahmet Avci","doi":"10.1080/17520363.2024.2403321","DOIUrl":"10.1080/17520363.2024.2403321","url":null,"abstract":"<p><p><b>Aim:</b> Myocarditis, an inflammatory disease of the myocardium, can range from asymptomatic cases to severe forms such as fulminant myocarditis. The systemic immune-inflammation index (SII) has emerged as a potential biomarker for various inflammatory diseases. This study aimed to determine the effect of SII on the prognosis of young adults with acute myocarditis and compare it with other cardiac markers.<b>Methods:</b> We retrospectively analyzed patients aged 18-40 years who were admitted to the emergency department with a diagnosis of acute myocarditis between January 2014 and January 2024. Patients were divided into non-fulminant and fulminant myocarditis groups based on diagnostic criteria.<b>Results:</b> SII, troponin I and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in the fulminant myocarditis group (<i>p</i> < 0.001 for all). Logistic regression analysis identified SII and NT-proBNP as independent predictors of fulminant myocarditis but not for troponin I (<i>p</i> = 0.064). The optimal cutoff value for SII in diagnosing fulminant myocarditis was 1020, with a sensitivity of 91% and specificity of 83%, outperforming troponin I. Patients with SII ≥1020 had a significantly higher risk of adverse outcomes.<b>Conclusion:</b> The SII enables early detection of adverse outcomes and is an independent predictor of prognosis in young adults with myocarditis.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"889-897"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of severity and duration of inflammation and hematological parameters on the outcome of subacute thyroiditis. 炎症的严重程度和持续时间以及血液学参数对亚急性甲状腺炎预后的影响。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17520363.2024.2342240
Hulya Hacisahinogullari, Mehmet Guven Gunver, Gulsah Yenidunya Yalin, Ozlem Soyluk Selcukbiricik, Ayse Kubat Uzum, Nurdan Gul
{"title":"The role of severity and duration of inflammation and hematological parameters on the outcome of subacute thyroiditis.","authors":"Hulya Hacisahinogullari, Mehmet Guven Gunver, Gulsah Yenidunya Yalin, Ozlem Soyluk Selcukbiricik, Ayse Kubat Uzum, Nurdan Gul","doi":"10.1080/17520363.2024.2342240","DOIUrl":"10.1080/17520363.2024.2342240","url":null,"abstract":"<p><p><b>Background:</b> The role of severity and duration of inflammatory findings on the development of persistent hypothyroidism and anemia has not been clarified in subacute thyroiditis (SAT). <b>Methods:</b> Demographic data and laboratory parameters of patients with SAT were analyzed retrospectively. <b>Results:</b> Permanent hypothyroidism was observed in 28.1% of patients. Baseline elevated erythrocyte sedimentation rate as defined >74.5 mm/h was found to be associated with permanent hypothyroidism, but the duration of inflammation was not different between the recovered and hypothyroid patients. Baseline hemoglobin values improved without specific therapy in 3.5 months. <b>Conclusion:</b> The initial severity but not the duration of inflammation increases the risk for the development of permanent thyroid dysfunction, and anemia improves with the resolution of inflammation.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"18 9","pages":"459-467"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation between LRG1 and CD4+ T cells, cognitive impairment and neurological function in patients with acute ischemic stroke. 急性缺血性脑卒中患者的 LRG1 和 CD4+ T 细胞、认知障碍和神经功能之间的关系。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.2217/bmm-2023-0674
Xiao Cheng, Hongen Wei, Yi Liu, Yaxuan Sun, Jianxin Ye, Pengyu Lu, Bin Han
{"title":"Relation between LRG1 and CD4<sup>+</sup> T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.","authors":"Xiao Cheng, Hongen Wei, Yi Liu, Yaxuan Sun, Jianxin Ye, Pengyu Lu, Bin Han","doi":"10.2217/bmm-2023-0674","DOIUrl":"10.2217/bmm-2023-0674","url":null,"abstract":"<p><p><b>Objective:</b> To assess the relationship between LRG1 and CD4<sup>+</sup> T cells, cognitive impairment and neurological function in acute ischemic stroke (AIS). <b>Methods:</b> Plasma LRG1 was detected by ELISA in 175 patients with AIS at baseline, day (D) 1, D7, month (M) 1 and M3. <b>Results:</b> LRG1 was negatively related to Th2 and Treg cells and positively linked to Th17 (all p < 0.05). LRG1 increased from baseline to D1, then decreased until M3 (p < 0.001). LRG1 at each assessment point was increased in patients with cognitive impairment or poor neurological function at M3 versus those without (all p < 0.05). <b>Conclusion:</b> LRG1 is linked to decreased Th2 and Tregs, increased Th17, cognitive impairment and nonideal neurological function recovery in patients with AIS.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"5-14"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma. MECOM：通过生物信息学和实验鉴定的肺腺癌诊断和预后标志物。
IF 2.2 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.2217/bmm-2023-0600
Anqi Li, Meng Li, Jing Wang, Jiejun Zhou, Tian Yang, Meng Fan, Kun Zhang, Hengxing Gao, Hui Ren, Mingwei Chen
{"title":"MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma.","authors":"Anqi Li, Meng Li, Jing Wang, Jiejun Zhou, Tian Yang, Meng Fan, Kun Zhang, Hengxing Gao, Hui Ren, Mingwei Chen","doi":"10.2217/bmm-2023-0600","DOIUrl":"10.2217/bmm-2023-0600","url":null,"abstract":"<p><p><b>Objective:</b> We aimed to explore the clinical value of MDS1 and EVI1 complex locus (<i>MECOM</i>) in lung adenocarcinoma (LUAD). <b>Methods:</b> Bioinformatics and experimental validation confirmed <i>MECOM</i> expression levels in LUAD. The value of <i>MECOM</i> was analyzed by receiver operating characteristic (ROC) curve and Cox regression analysis. <b>Results:</b> Serum MECOM levels were lower in LUAD and correlated with gender, TNM stage, tumor size, lymph node metastasis and distant metastasis. The ROC curve showed that the area under the curve of MECOM was 0.804 for LUAD and, of note, could reach 0.889 for advanced LUAD; specificity was up to 90%. <b>Conclusion:</b> <i>MECOM</i> may contribute to independently identifying LUAD patients, particularly in advanced stages.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"79-91"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of salivary melatonin levels in patients with bruxism: a case-control study. 磨牙症患者唾液褪黑激素水平的比较评估：一项病例对照研究。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1080/17520363.2024.2398982
Ceyda Gürhan, Ercan Saruhan, Ali Batuhan Bayırlı
{"title":"Comparative evaluation of salivary melatonin levels in patients with bruxism: a case-control study.","authors":"Ceyda Gürhan, Ercan Saruhan, Ali Batuhan Bayırlı","doi":"10.1080/17520363.2024.2398982","DOIUrl":"10.1080/17520363.2024.2398982","url":null,"abstract":"<p><p><b>Aim:</b> To examine whether there is any difference in the levels of salivary melatonin between bruxism and nonbruxism groups and to compare the stress and anxiety levels between the two groups.<b>Materials & methods:</b> Patients meeting the probable bruxism criteria according to the International Consensus on the Assessment of Bruxism Criteria were included in the bruxism group. The salivary melatonin concentrations of both groups were measured using an ELISA kit. To determine the relationship between stress and bruxism, the State-Trait Anxiety Inventory (STAI) test was used.<b>Results:</b> The bruxism group had a significantly lower night-time salivary melatonin level than the control group (<i>p</i> < 0.05). No significant difference was determined between the bruxism group and the control group in respect of the STAI-T scores (<i>p</i> > 0.05).<b>Conclusion:</b> The study findings revealed a strong relationship between a low melatonin level and bruxism.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"843-851"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indices and ferritin level that predict organ involvement in adult-onset Still's disease. 预测成人型斯蒂尔病器官受累的指标和铁蛋白水平。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-24 DOI: 10.1080/17520363.2024.2403330
Mehmet Nur Kaya, Özlem Kılıç, Ezgi Çimen Güneş, Duygu Tecer, Sedat Yılmaz
{"title":"Indices and ferritin level that predict organ involvement in adult-onset Still's disease.","authors":"Mehmet Nur Kaya, Özlem Kılıç, Ezgi Çimen Güneş, Duygu Tecer, Sedat Yılmaz","doi":"10.1080/17520363.2024.2403330","DOIUrl":"10.1080/17520363.2024.2403330","url":null,"abstract":"<p><p><b>Aim:</b> The aim of the study is to evaluate whether C-reactive protein to albumin ratio (CAR), lactate dehydrogenase to albumin ratio (LAR), ferritin to erythrocyte sedimentation rate ratio (FER), systemic immune-inflammation index (SII), prognostic nutritional index (PNI) indices and ferritin level can predict organ involvement in adult-onset Still's disease (AOSD) patients.<b>Methods:</b> This study was planned as a cross-sectional study. Univariate and multivariate logistic regression analyses were performed to evaluate the usefulness of ferritin level and inflammatory indices in defining organ involvement.<b>Results:</b> Sixty-one patients diagnosed with AOSD were included in this study. Multivariate logistic regression analyzes showed that LAR (OR 1.028, 95% CI: 1.011-1.044) (<i>p</i> = 0.001) index predicted lymphadenopathy involvement, CAR (OR 1.249, 95% CI: 1.087-1.435) (<i>p</i> = 0.002) index predicted hepatomegaly involvement, ferritin level (OR 1.004, 95% CI: 1.001-1.008) (<i>p</i> = 0.007) predicted splenomegaly involvement, FER (OR 1.085, 95% CI: 1.012-1.164) (<i>p</i> = 0.021) and PNI (OR 0.271, 95% CI: 1.132-0.553) (<i>p</i> < 0.001) index predicted the occurrence of serositis.<b>Conclusion:</b> This study showed that ferritin level, CAR, FER, PNI and LAR markers may predict organ involvement at diagnosis in AOSD patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"899-906"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-6 and stroke recurrence in ischemic stroke. IL-6 与缺血性中风的中风复发。
IF 1.9 4区 医学
Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/17520363.2024.2389038
Yuanfeng Jiang, Tao Fan
{"title":"IL-6 and stroke recurrence in ischemic stroke.","authors":"Yuanfeng Jiang, Tao Fan","doi":"10.1080/17520363.2024.2389038","DOIUrl":"10.1080/17520363.2024.2389038","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to evaluate the predictive value of IL-6 for stroke recurrence in acute ischemic stroke.<b>Methods:</b> Patients who were admitted within 48 h of onset were included. At 3-month, stroke recurrence was assessed. IL-6 levels were measured in serum samples taken upon admission.<b>Results:</b> Out of the 305 patients, 47 (15.4%) experienced a stroke recurrence. The risk of stroke recurrence increased by 8% (OR: 1.08; 95% CI: 1.04-1.11; <i>p</i> < 0.001) for every 1 pg/ml increase in IL-6 serum level, both in unadjusted and adjusted analyses (6%; OR: 1.06; 95% CI: 1.02-1.10; <i>p</i> = 0.001).<b>Conclusion:</b> The study supports the usefulness of IL-6 as a predictive biomarker for stroke recurrence after acute ischemic stroke.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"739-747"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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