Biomarkers in medicine最新文献_第7页

Association of peripheral blood brain-derived neurotrophic factor (BDNF) levels with the use of technology-assisted stroke rehabilitation: a systematic review and meta-analysis. 外周血脑源性神经营养因子（BDNF）水平与技术辅助卒中康复的关联：一项系统回顾和荟萃分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.1080/17520363.2026.2659657

Rabiatul Adawiyah Mohamad Noor, Hanim Afzan Ibrahim, Wan Muhamad Amir W Ahmad, Muhammad Hafiz Hanafi, Muzaimi Mustapha, Kannan Thirumulu Ponnuraj, Nur Karyatee Kassim

{"title":"Association of peripheral blood brain-derived neurotrophic factor (BDNF) levels with the use of technology-assisted stroke rehabilitation: a systematic review and meta-analysis.","authors":"Rabiatul Adawiyah Mohamad Noor, Hanim Afzan Ibrahim, Wan Muhamad Amir W Ahmad, Muhammad Hafiz Hanafi, Muzaimi Mustapha, Kannan Thirumulu Ponnuraj, Nur Karyatee Kassim","doi":"10.1080/17520363.2026.2659657","DOIUrl":"10.1080/17520363.2026.2659657","url":null,"abstract":"Aims: Advanced rehabilitation technologies are progressively integrated into stroke rehabilitation. However, their capacity to elicit neurological benefits via neuroplasticity biomarkers, particularly brain-derived neurotrophic factor (BDNF), and their association with functional recovery remain poorly understood. This review aimed to systematically evaluate the effectiveness of technology-assisted rehabilitation on blood-based biomarkers in stroke patients, discuss their potential link to functional recovery, and quantitatively analyze BDNF through meta-analysis.Methods: We conducted a systematic review and a meta-analysis of studies published from January 2010 to July 2025. A comprehensive search was performed using PubMed, Scopus, and Cochrane Library. Screening was conducted using Rayyan software, and analysis was performed using SPSS Statistics.Results: Fifteen studies were included in the systematic review, with eight eligibles for meta-analysis. The serum BDNF subgroup presented a trend toward higher levels in the technology-assisted group (SMD = 0.44; 95% CI: -0.12 to 1.01; p = 0.13), while the plasma subgroup showed a significant decrease (SMD = -0.17; 95% CI: -1.24 to -0.18; p = 0.01).Conclusions: Technology-assisted rehabilitation may influence neural repair biomarkers, suggesting a potential role in stroke recovery. However, inconsistencies across studies, particularly short intervention durations and heterogeneous study designs, indicate the need for high-quality and longitudinal investigations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"297-310"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dynamic trajectories of serum tumor markers and survival outcomes in patients with extensive-stage small cell lung cancer: a retrospective cohort study. 大分期小细胞肺癌患者血清肿瘤标志物动态轨迹与生存结局的关联：一项回顾性队列研究

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-20 DOI: 10.1080/17520363.2026.2659653

Bin Jia, Boying Wu, Shuaiyin Chen, Youxiang Wang, Quanman Hu, Ping Li, Yanru Qin

{"title":"Association between dynamic trajectories of serum tumor markers and survival outcomes in patients with extensive-stage small cell lung cancer: a retrospective cohort study.","authors":"Bin Jia, Boying Wu, Shuaiyin Chen, Youxiang Wang, Quanman Hu, Ping Li, Yanru Qin","doi":"10.1080/17520363.2026.2659653","DOIUrl":"10.1080/17520363.2026.2659653","url":null,"abstract":"Background: Previous studies on extensive-stage small cell lung cancer (ES-SCLC) have primarily focused on serum tumor markers (STM) measurements at a single time point, overlooking the prognostic value of sequential STM monitoring.Methods: We conducted a retrospective cohort study of 253 patients with ES-SCLC and applied latent class growth mixed modeling to define trajectory groups for neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and cytokeratin 19 fragment (CYFRA21-1).Results: Overall survival (OS) and adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for mortality in the persistent-rising vs. low-stable groups were 1.19 (0.73 - 1.95), 1.58 (1.07 - 2.33), and 2.34 (1.11 - 4.92) for NSE, CEA, and CYFRA21-1, respectively. Persistent elevations of CEA (p = 0.021) and CYFRA21-1 (p = 0.026) were independent OS prognostic factors. For progression-free survival (PFS), adjusted HRs (95% CIs) were 2.27 (1.38 - 3.74), 1.22 (0.83 - 1.80), and 0.99 (0.48 - 2.05) for NSE, CEA, and CYFRA21-1, respectively, with NSE (p < 0.001) independently predicting PFS. Combined subgroups (three-low, one-high, and two-high) demonstrated significant OS and PFS stratification (p < 0.001).Conclusion: Dynamic monitoring of NSE, CEA, and CYFRA21-1 provides a valuable approach for prognostic prediction in patients with ES-SCLC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"285-295"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: diagnostic utility of procalcitonin for detecting bacteremia in persons who inject drugs. 响应：降钙素原检测注射吸毒者菌血症的诊断效用。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-05-06 DOI: 10.1080/17520363.2026.2671001

Ashok Kumar Pannu

引用次数: 0

Scientific trends in obstructive sleep apnea biological and clinical assessment indicators: a bibliometric analysis. 阻塞性睡眠呼吸暂停生物学和临床评估指标的科学趋势：文献计量学分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-05-08 DOI: 10.1080/17520363.2026.2671003

Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao

{"title":"Scientific trends in obstructive sleep apnea biological and clinical assessment indicators: a bibliometric analysis.","authors":"Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao","doi":"10.1080/17520363.2026.2671003","DOIUrl":"10.1080/17520363.2026.2671003","url":null,"abstract":"Aims: Obstructive sleep apnea (OSA) is characterized by diverse biological and clinical disturbances, yet no study has systematically examined scientific developments related to its objective assessment measures. This study aimed to map the development, research hotspots, and emerging trends related to biological and clinical assessment indicators in OSA.Materials and methods: Publications indexed in the Web of Science Core Collection and Scopus from 2000 to 2025 were reviewed. A total of 1,793 articles were analyzed using VOSviewer, CiteSpace, the R bibliometrix package, and Python. The analysis assessed publication and citation trends, country contributions, keyword co-occurrence, and thematic evolution to map global research patterns in OSA assessment.Results: The number of publications increased steadily over time, reflecting growing research interest in multidimensional assessment approaches. Research themes have evolved from general inflammatory and metabolic markers toward more mechanistic and clinically oriented indicators, including oxidative stress pathways, circulating biomarkers, and cerebrovascular or cognitive related measures.Conclusions: Current research increasingly emphasizes integrated biological and clinical assessment frameworks for better characterization of OSA. Future studies should focus on validation, methodological standardization, and the integration of multiple assessment domains to facilitate clinical translation.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"381-393"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2025-10-14 DOI: 10.1080/17520363.2025.2574787

引用次数: 0

Diagnostic value of sclerostin, RANKL, oxidized LDL, and phoenixin-14 levels in acute ischemic stroke. 硬化蛋白、RANKL、氧化LDL和凤凰素-14水平在急性缺血性脑卒中中的诊断价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-13 DOI: 10.1080/17520363.2026.2641471

Derya Öztürk, Fatih Özcelik, Bedriye Müge Sönmez, Ertuğrul Altınbilek, Ayşe Beyza Bekgöz, Serpil Bulut, Selin Çelik, Adem Melekoğlu, Abuzer Coşkun, Mustafa Çalık

{"title":"Diagnostic value of sclerostin, RANKL, oxidized LDL, and phoenixin-14 levels in acute ischemic stroke.","authors":"Derya Öztürk, Fatih Özcelik, Bedriye Müge Sönmez, Ertuğrul Altınbilek, Ayşe Beyza Bekgöz, Serpil Bulut, Selin Çelik, Adem Melekoğlu, Abuzer Coşkun, Mustafa Çalık","doi":"10.1080/17520363.2026.2641471","DOIUrl":"10.1080/17520363.2026.2641471","url":null,"abstract":"Aims: Acute ischemic stroke (AIS) is a leading cause of mortality and morbidity, yet largely preventable. An urgent clinical need exists for new biomarkers that enable early, noninvasive, and accurate diagnosis, even before the incident occurs. This study aims to determine the valency of serum sclerostin (SOST), receptor activator of nuclear factor-kappa B ligand (RANKL), oxidized low-density lipoproteins (OxLDL), and phoenixin-14 in AIS.Patients and methods: A case-control study was conducted in the emergency department (ED) of a tertiary care hospital between June 2024 and September 2024, including 48 patients with AIS and 40 healthy individuals. The enzyme-linked immunosorbent assay was used to determine the levels of SOST, OxLDL, RANKL, and phoenixin-14. Diagnostic accuracy and independent associations with AIS were examined.Results: Biomarker levels were significantly higher in AIS group. SOST was the best, with an area under the curve of 0.809. A one-unit increase in SOST and OxLDL levels increased the probability of stroke by 1.418 and 1.006 times, respectively.Conclusions: SOST, OxLDL, RANKL, and phoenixin-14 May be complementary markers that warrant further validation, even though the results show an association rather than a causal relationship, suggesting they might be useful for differentiating AIS from healthy controls.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"233-240"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the neutrophil to lymphocyte ratio and clinical outcomes in cancers: a systematic review and meta-analysis. 中性粒细胞与淋巴细胞比值与癌症临床结局的关系：一项系统综述和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1080/17520363.2026.2625220

Siling Zhu, Wenliang Li, Hongte Zhang, Yusen Lin, Zisheng Chen

{"title":"Association of the neutrophil to lymphocyte ratio and clinical outcomes in cancers: a systematic review and meta-analysis.","authors":"Siling Zhu, Wenliang Li, Hongte Zhang, Yusen Lin, Zisheng Chen","doi":"10.1080/17520363.2026.2625220","DOIUrl":"10.1080/17520363.2026.2625220","url":null,"abstract":"Purpose: This meta-analysis aimed to evaluate the pan-cancer prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for risk stratification in patients with cancer.Methods: We systematically searched Embase, PubMed, Google Scholar, and the Cochrane Library. The analysis included prospective studies, randomized controlled trials (RCTs), and post-hoc RCT analyses reporting multivariate-adjusted associations between the NLR and survival outcomes.Results: Elevated NLR was significantly associated with worse overall survival (HR 1.61, 95% CI 1.44-1.80) and progression-free survival (HR 1.42, 1.27-1.59). Subgroup analyses by cancer type showed consistent associations in lung (OS-HR 2.29, 1.56-3.37; PFS-HR 1.73, 1.13-2.65), colorectal (OS-HR 1.88, 1.49-2.36; PFS-HR 1.43, 1.12-1.82), gastric (OS-HR 1.65, 1.46-1.87; PFS-HR 1.88, 1.14-3.11), and breast cancers (OS-HR 1.53, 1.27-1.83; PFS-HR 1.45, 1.29-1.64). Analysis by treatment modality revealed differential prognostic effects, including for chemotherapy (OS-HR 1.48, 1.34-1.65; PFS-HR 1.34, 1.14-1.57), immunotherapy (OS-HR 3.07, 1.65-5.71; PFS-HR 1.94, 1.12-3.36), surgery (OS-HR 1.90, 1.44-2.52), and targeted therapy plus chemotherapy (OS-HR 1.56, 1.28-1.90; PFS-HR 1.46, 1.22-1.76).Conclusion: An elevated NLR is associated with inferior clinical outcomes across multiple cancers, with the magnitude of its prognostic impact varying by treatment modality.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"251-261"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying predictive proteomic biomarkers of selective serotonin reuptake inhibitor treatment effect in depression. 确定选择性血清素再摄取抑制剂治疗抑郁症效果的预测性蛋白质组学生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-11 DOI: 10.1080/17520363.2026.2641467

Seungyeon Lee, Sora Mun, Yeeun Yun, Doojin Kim, Jiyeong Lee, Hee-Gyoo Kang

{"title":"Identifying predictive proteomic biomarkers of selective serotonin reuptake inhibitor treatment effect in depression.","authors":"Seungyeon Lee, Sora Mun, Yeeun Yun, Doojin Kim, Jiyeong Lee, Hee-Gyoo Kang","doi":"10.1080/17520363.2026.2641467","DOIUrl":"10.1080/17520363.2026.2641467","url":null,"abstract":"Objective: Major depressive disorder (MDD) is the most common mood disorder affecting human health. The complex pathogenesis of MDD remains poorly understood, and the heterogeneity associated with the various subtypes limits our understanding of the pathophysiological mechanisms. Antidepressants are the main treatment for depressive symptoms, with selective serotonin reuptake inhibitors (SSRIs) most commonly used; however, predictors of SSRI response and their pharmacological mechanisms remain unclear. In this study, we aimed to identify the biomarkers that can predict treatment response and efficacy of SSRIs.Methods: We compared serum protein levels between patients receiving SSRIs treatment and those who achieved remission through SSRI treatment to identify predictive biomarkers for SSRI treatment effect using a liquid chromatography-mass spectrometer.Results: Sexhormone-binding globulin(SHBG) level was high in patients who achieved remission after SSRItreatment and was substantially different from that in patients with depression who received treatment without remission.Conclusion: SHBG may serve as a predictive biomarker of SSRI treatment response and may help elucidate the molecular mechanisms of SSRI therapy in MDD, including the interplay between sex-hormone regulation and immune - inflammatory pathways.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"223-231"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder. 同步睡眠试验方案：在快速眼动睡眠行为障碍中检测皮肤磷酸化α -同步核蛋白。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1080/17520363.2026.2641474

Sarrah Marcotte, Todd Levine, Roy Freeman, Christopher H Gibbons

{"title":"The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder.","authors":"Sarrah Marcotte, Todd Levine, Roy Freeman, Christopher H Gibbons","doi":"10.1080/17520363.2026.2641474","DOIUrl":"10.1080/17520363.2026.2641474","url":null,"abstract":"Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal neurodegenerative disease of misfolded alpha-synuclein (P-SYN) with a high risk of phenoconversion to a clinically apparent synucleinopathy (including Parkinson's disease, multiple system atrophy, or dementia with Lewy bodies) over 15 years.Objectives: To determine rates of cutaneous P-SYN deposition in iRBD, to quantify changes in PSYN deposition over time, and to determine if P-SYN deposition patterns and amounts predict phenoconversion to a specific type of synucleinopathy.Clinical trial protocol: In a prospective, blinded study we will recruit 80 individuals with polysomnography confirmed iRBD or probable RBD using standard diagnostic criteria. Skin biopsies with dual immunohistochemical immunostaining for nerve fibers (protein gene product 9.5) and P-SYN will be completed at 3 sites using standard methodology. Quantitative measures of P-SYN and nerve fiber density will be measured blinded to any clinical data and will be followed longitudinally to determine the final clinical diagnosis.Discussion: Patients with iRBD are an important population to study due to the high rates of phenoconversion to clinically apparent synucleinopathy. Defining the frequency of P-SYN deposition and the risk of phenoconversion will aid in the development of future clinical trials that seek to alter the natural history of synucleinopathies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"199-206"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary DKK3 as a biomarker for pediatric CKD progression: a review of current evidence. 尿DKK3作为儿童CKD进展的生物标志物：对现有证据的回顾

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1080/17520363.2026.2622051

Jan Boeckhaus, Christoph Licht, Matthew Hall, Jun Oh, Thimoteus Speer

{"title":"Urinary DKK3 as a biomarker for pediatric CKD progression: a review of current evidence.","authors":"Jan Boeckhaus, Christoph Licht, Matthew Hall, Jun Oh, Thimoteus Speer","doi":"10.1080/17520363.2026.2622051","DOIUrl":"10.1080/17520363.2026.2622051","url":null,"abstract":"Chronic kidney disease (CKD) is a significant challenge in pediatric care, as it can lead to substantial long-term comorbidities, reduced quality of life and reduced lifetime. Early detection of pediatric CKD is vital for preventive care and maintaining organ function. Therefore, there is a critical need for biomarkers that should ideally offer early detection (before glomerular filtration rate (GFR) decline), possess high specificity for the underlying renal disease process (e.g. tubular or glomerular damage), and show strong prognostic value for predicting disease progression. This narrative review examines the role of Dickkopf-3 (DKK3), a pro-fibrotic protein released by renal tubular cells during pathophysiological stress, in the context of pediatric CKD. In experimental models, DKK3 has been shown to drive renal tubulointerstitial fibrosis by modulating the WNT/β-catenin signaling pathway. There is increasing evidence suggesting that urinary DKK3 (uDKK3) levels could serve as a valuable biomarker for identifying pediatric CKD patients at high risk for rapid disease progression, regardless of the underlying etiology. This review highlights uDKK3 as a potential marker for the early detection and risk stratification of pediatric patients with CKD, which could lead to a personalized approach to monitor CKD beyond estimated GFR and albuminuria.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"20 4","pages":"241-249"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0