Biomarkers in medicine最新文献_第7页

Predictive power of ALBI score-based nomogram for 30-day mortality following transcatheter aortic valve implantation. 基于ALBI评分的nomogram经导管主动脉瓣植入术后30天死亡率预测能力

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-03-30 DOI: 10.1080/17520363.2025.2483157

Abdullah Yildirim, Omer Genc, Mert Evlice, Aslan Erdogan, Emre Pacaci, Ahmet Ozderya, Murat Gokhan Yerlikaya, Emre Sezici, Yeliz Guler, Omer Sen, Ahmet Guler, Ali Riza Akyuz, Levent Korkmaz, Ibrahim Halil Kurt

{"title":"Predictive power of ALBI score-based nomogram for 30-day mortality following transcatheter aortic valve implantation.","authors":"Abdullah Yildirim, Omer Genc, Mert Evlice, Aslan Erdogan, Emre Pacaci, Ahmet Ozderya, Murat Gokhan Yerlikaya, Emre Sezici, Yeliz Guler, Omer Sen, Ahmet Guler, Ali Riza Akyuz, Levent Korkmaz, Ibrahim Halil Kurt","doi":"10.1080/17520363.2025.2483157","DOIUrl":"10.1080/17520363.2025.2483157","url":null,"abstract":"Aim: This retrospective, multi-center study evaluates the relationships between novel liver function scoring systems - Albumin-Bilirubin (ALBI) score, EZ-ALBI, PALBI, and MELD-XI - and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). Feature importance was assessed with SHAP-values via the XGBoost-algorithm.Results: The ALBI score exhibited the strongest association with 30-day mortality after TAVI (AUC = 0.723, p < 0.001), outperforming other scores in this regard and consistently demonstrating predictive power across various subgroup populations. Higher 30-day mortality rates were observed in the higher tertiles of the ALBI score compared to the lower tertiles (log-rank p-value = 0.004). The ALBI-based nomogram (C-index = 0.81, 95% CI:0.73-0.86, p = 0 < 001) demonstrated superior predictive power for 30-day mortality post-TAVI compared to the STS (C-index = 0.71, 95% CI :0.64-0.77, p = 0 < 001). In addition, the nomogram showed a significant improvement in reclassification (69.3%, p < 0.001) and a stronger discrimination 15.2%, p < 0.001) compared to the STS. It integrates nine variables, first ALBI score (SHAP:1.165), including NYHA class (0.594), body mass index (0.510), glomerular filtration rate, creatinine, hemoglobin, gender, predilatation requirement, presence of chronic kidney disease, and providing a comprehensive risk assessment tool.Conclusion: This study exhibits the significance of liver dysfunction with AS patients and suggests incorporating liver function parameters in pre-operative risk assessments for better clinical outcomes in TAVI procedures.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"305-316"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCR targeting 16S rRNA, cfb, and hylB for group B Streptococcus detection in women with 35 to 37 weeks of pregnancy. PCR靶向16S rRNA、cfb和hylB检测妊娠35 ~ 37周妇女B组链球菌

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-05-12 DOI: 10.1080/17520363.2025.2496132

Juan Liu, Jun Yan, Juan Lv

{"title":"PCR targeting 16S rRNA, cfb, and hylB for group B Streptococcus detection in women with 35 to 37 weeks of pregnancy.","authors":"Juan Liu, Jun Yan, Juan Lv","doi":"10.1080/17520363.2025.2496132","DOIUrl":"10.1080/17520363.2025.2496132","url":null,"abstract":"Aims: Polymerase chain reaction (PCR) is a rapid molecular technique for pathogen detection, but its application in detecting group B Streptococcus (GBS) requires further exploration. This study assessed the diagnostic performance of the PCR method for GBS detection in pregnant women with 35 to 37 weeks of pregnancy.Methods: This study enrolled 116 women at 35-37 weeks of pregnancy and simultaneously collected two vaginal swab samples for GBS detection via culture and PCR methods.Results: Through the culture method, 21 (18.1%) samples were positive for GBS. Moreover, 24 (20.7%), 23 (19.8%), and 23 (19.8%) samples were positive for GBS according to PCR methods targeting 16S rRNA, cfb, and hylB, respectively. The results of PCR-based GBS detection of 16S rRNA (Kappa value = 0.917, p < 0.01), cfb (Kappa value = 0.944, p < 0.01), and hylB (Kappa value = 0.944, p < 0.01) were consistent with those of the culture method. The sensitivity and specificity were 1.000 and 0.968 for the PCR method targeting 16S rRNA, 1.000 and 0.979 for cfb, and 1.000 and 0.979 for hylB, respectively.Conclusion: PCR targeting 16S rRNA, cfb, and hylB may serve as a reliable diagnostic method for GBS detection in women with 35 to 37 weeks of pregnancy.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 10","pages":"379-384"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing risk stratification post-myocardial infarction: prognostic value of NT-proBNP and fQRS. 增强心肌梗死后风险分层：NT-proBNP和fQRS的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17520363.2025.2473875

Ashok Kumar Pannu

引用次数: 0

Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer. 术前血液中性粒细胞/淋巴细胞比值、红细胞压积和纤维蛋白原预测结直肠癌预后。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1080/17520363.2025.2473310

Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen

{"title":"Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.","authors":"Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen","doi":"10.1080/17520363.2025.2473310","DOIUrl":"10.1080/17520363.2025.2473310","url":null,"abstract":"Objective: To investigate the prognostic potential of preoperative blood neutrophil to lymphocyte ratio (NLR), hematocrit (HCT) and Fibrinogen (FIB) level in patients with colorectal cancer (CRC).Methods: The data of 268 patients with CRC who underwent radical surgery from March 2013 to August 2017 in the First Affiliated Hospital of Guangzhou Medical University (Guangzhou, China) were retrospectively collected. The correlations between preoperative blood NLR, HCT and FIB level and the clinicopathologic features and prognosis were explored by Cox regression in the patients with CRC.Results: Univariate and multivariate analyses identified preoperative blood with high NLR (HR = 2.265, 95% CI: 1.437-3.570), low HCT (HR = 1.575, 95% CI: 1.010-2.454), and high FIB (HR = 1.667, 95% CI: 1.067-2.605) as independent predictors of reduced 5-year overall survival (OS). Furthermore, the patients were stratified into high (with 3 predictors), middle (with 2 predictors) and low (with 0 or 1 predictors) risk groups according to the number of the 3 independent prognostic predictors. The more independent predictors a patient has, the poorer their prognosis tends to be.Conclusions: Preoperative NLR, HCT, and FIB serve as cost-effective prognostic biomarkers in CRC. Their combination enables precise risk stratification, guiding personalized postoperative management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"251-258"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index. 急性冠脉综合征全因死亡率的新指标：CALLY指数。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483159

Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay

{"title":"A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index.","authors":"Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay","doi":"10.1080/17520363.2025.2483159","DOIUrl":"10.1080/17520363.2025.2483159","url":null,"abstract":"Aims: This study aimed to identify the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting all-cause mortality in acute coronary syndrome (ACS) patients who have undergone primary percutaneous coronary intervention (pPCI) for revascularization.Materials and methods: 505 patients who presented with ACS and underwent pPCI were retrospectively included in this single center study. CALLY index and other five prognostic scores were calculated. The median follow-up was 40 months. All-cause mortality was defined as the primary endpoint.Results: The median age of the patients was 59 years, 23.4% were female. The CALLY index was categorized into low (<0.7) and high (≥0.7). Age (p = 0.038), concomitant atrial fibrillation (p = 0.023), previous CABG (p = 0.001), ACE-I/ARB/ARNI use (p = 0.015), diuretic use (p = 0.021), and a low-CALLY index (p < 0.001) were identified as independent predictors of all-cause mortality in multivariate cox regression analysis. When compared to other prognostic scores according to AUC in ROC analysis, the CALLY index demonstrated the best ability to predict all-cause mortality. Additionally, patients with a high-CALLY index exhibited significantly better survival outcomes compared to those with a low-CALLY index (log-rank:p < 0.001).Conclusions: CALLY index can be utilized as a novel prognostic score for predicting all-cause mortality in ACS patients who have undergone pPCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"287-294"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study. 作为急性肾损伤预后标志物的可溶性 Klotho 平均水平：90 天随访研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-22 DOI: 10.1080/17520363.2025.2481018

ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu

{"title":"Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study.","authors":"ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu","doi":"10.1080/17520363.2025.2481018","DOIUrl":"10.1080/17520363.2025.2481018","url":null,"abstract":"Background: Klotho is highly expressed in the kidney and confers pleiotropic kidney protective effects. This study aimed to assess the soluble average Klotho level and its relationship to renal function and outcomes in participants with acute kidney injury (AKI).Methods: We recruited 102 participants with AKI and 30 healthy controls (HCs). For patients with AKI, serum soluble (sKlotho) levels upon admission to and discharge from hospital were measured to assess the relationship between sKlotho level and kidney function. Individuals with AKI were followed up for 90 days to determine the association between their average sKlotho level and short-term AKI outcomes.Results: The baseline sKlotho level in individuals with AKI at admission was significantly lower than that in HCs. For individuals with AKI, the sKlotho level was significantly lower in stage 3 than in stage 1 or 2. The sKlotho level was restored along with renal function improvement at discharge. During follow-up, a lower average, but not baseline, sKlotho level, or average sKlotho/creatinine ration predicted more AKI clinical outcomes.Conclusion: The sKlotho level decreased significantly with kidney injury and represented severity. The average sKlotho level inversely correlated with detrimental kidney outcomes and may have potential diagnostic and predictive roles in AKI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"243-250"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients. HE4水平与非小细胞肺癌患者PET代谢参数的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17520363.2025.2471744

Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan

{"title":"Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients.","authors":"Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan","doi":"10.1080/17520363.2025.2471744","DOIUrl":"10.1080/17520363.2025.2471744","url":null,"abstract":"Aim: To investigate the relationship between serum human epididymis protein 4 (HE4) levels and metabolic parameters of positron emission tomography (PET) imaging in patients with lung cancer.Methods: Sixty non-small cell lung cancer (NSCLC) patients were included in this prospective study. Demographic information, smoking status, comorbid pathologies, preoperative HE4 levels, PET imaging metabolic parameters, disease stage and histopathology were recorded.Results: Significant positive correlations between serum HE4 levels and all the metabolic parameters were observed (p < 0.05). In univariate regression analyses, it was observed that high serum HE4 levels could indicate tumor be squamous cell carcinoma (SCC) (p = 0.029), advanced T stage (p = 0.041), and have high maximum standart uptake value (SUVmax) (p = 0.017).Conclusion: Serum HE4 levels can be used as a biomarker to predict tumor burden and metabolic activity for NSCLC patients. Although sufficient per power analysis, this study may have benefited from further expansion, and by patient heterogeneity in TNM stage and tumor histology, potentially affecting the assessment of parameter relationships.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"259-265"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk. 冠状动脉扩张预测：Intermountain风险评分在识别危险患者中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483158

Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan

{"title":"Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk.","authors":"Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan","doi":"10.1080/17520363.2025.2483158","DOIUrl":"10.1080/17520363.2025.2483158","url":null,"abstract":"Aims: This study evaluates the association between the Intermountain Risk Score (IMRS) and coronary artery ectasia (CAE) to determine its predictive value.Materials & methods: A retrospective study was conducted at a tertiary hospital from January 2019 to January 2024. A total of 446 patients (226 with CAE, 220 controls) were included. Clinical, laboratory, and angiographic data were analyzed. IMRS was calculated based on routine demographic and laboratory parameters. Statistical analyses included logistic regression and receiver operating characteristic (ROC) curve analysis.Results: Patients with CAE had significantly higher IMRS scores (p = 0.011) and were more likely to fall into high-risk IMRS categories (p = 0.002). Smoking (HR: 3.744, p = 0.045), mean corpuscular volume (HR: 1.105, p = 0.019), and IMRS color category (HR: 5.255, p = 0.016) were independent predictors. ROC analysis showed an AUC of 0.617 for IMRS score and 0.627 for IMRS color category.Conclusions: IMRS is a significant predictor of CAE and may serve as a practical risk stratification tool. Higher-risk patients could benefit from closer monitoring and targeted interventions. Further validation in prospective studies is needed.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"295-304"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome. TyG指数在预测急性冠状动脉综合征后左室低射血分数中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1080/17520363.2025.2485017

Ozlem Ozbek, Erdal Belen

{"title":"The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.","authors":"Ozlem Ozbek, Erdal Belen","doi":"10.1080/17520363.2025.2485017","DOIUrl":"10.1080/17520363.2025.2485017","url":null,"abstract":"Aims: This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.Methods & results: This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (p = 0.004), diabetes mellitus (p = 0.017), previous coronary artery disease (CAD) (p < 0.001), ST-elevation myocardial infarction (STEMI) (p < 0.001) and high (≥4.95) TyG index (p < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (p = 0.031), previous CAD (p = 0.001), peripheral artery disease (p = 0.038), renal diseases (p = 0.011), STEMI (p < 0.001) and high (≥5.10) TyG index (p < 0.001).Conclusions: The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"267-275"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KLK8: charting new territories in left ventricular hypertrophy biomarker research. KLK8：左心室肥厚生物标志物研究的新领域。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1080/17520363.2025.2483153

Buqing Cao, Wenhong Yu, Zhihong Diao, Zhenli Ma, Shineng Yan, Lihua Yang, Xiaoqun Huang, Jingmei Yang

{"title":"KLK8: charting new territories in left ventricular hypertrophy biomarker research.","authors":"Buqing Cao, Wenhong Yu, Zhihong Diao, Zhenli Ma, Shineng Yan, Lihua Yang, Xiaoqun Huang, Jingmei Yang","doi":"10.1080/17520363.2025.2483153","DOIUrl":"10.1080/17520363.2025.2483153","url":null,"abstract":"Objective: This study investigates the diagnostic potential of serum Kallikrein-related peptidase 8 (KLK8) in detecting left ventricular hypertrophy (LVH).Methods: A total of 62 hypertensive patients with LVH, 60 without LVH, and 60 healthy controls were analyzed. LVH was defined by echocardiography using LVMI thresholds (>95 g/m2 for females, >115 g/m2 for males). Serum KLK8 levels were measured via ELISA, and receiver operating characteristic (ROC) curve analysis assessed its diagnostic performance.Results: KLK8 levels were significantly higher in hypertensive patients with LVH (8.59 ± 1.59 ng/mL) than in those without LVH (5.80 ± 1.35 ng/mL) and healthy controls (3.68 ± 0.82 ng/mL). KLK8 positively correlated with blood pressure and cardiac structural parameters, including IVST, LVPWT, and LVEDD. ROC analysis revealed high sensitivity and specificity, indicating KLK8's potential as a biomarker for early LVH detection in hypertension.Conclusion: In hypertensive patients, KLK8 demonstrates good diagnostic value in predicting LVH.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"277-286"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0