Biomarkers in medicine最新文献

Looking beyond a single blood eosinophil count in COPD. COPD患者血液中嗜酸性粒细胞计数的变化。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-31 DOI: 10.1080/17520363.2026.2726200

Mauro Maniscalco, Salvatore Fuschillo, Marco Vanetti, Antonio Spanevello

引用次数: 0

Meta-analysis of the relationship between preoperative systemic immune inflammation index and prognosis of patients with biliary tract cancer. 胆道癌患者术前全身免疫炎症指数与预后关系的meta分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-20 DOI: 10.1080/17520363.2026.2720101

Jiale Liang, Zepu Wang, Dan Lv, Hongfang Tuo

{"title":"Meta-analysis of the relationship between preoperative systemic immune inflammation index and prognosis of patients with biliary tract cancer.","authors":"Jiale Liang, Zepu Wang, Dan Lv, Hongfang Tuo","doi":"10.1080/17520363.2026.2720101","DOIUrl":"https://doi.org/10.1080/17520363.2026.2720101","url":null,"abstract":"Objective: To evaluate the prognostic value of preoperative systemic immune-inflammation index (SII) for overall survival, recurrence-free survival, and clinicopathological features in patients with biliary tract cancer (BTC).Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and major Chinese databases. Seventeen studies involving 4,965 patients were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HR) or odds ratios (OR) with 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Subgroup, sensitivity analyses, and funnel plots were conducted to explore heterogeneity and assess robustness.Results: High preoperative SII was significantly associated with worse overall survival (OS) (HR = 1.98, 95% CI = 1.76-2.23, p < 0.001) and recurrence-free survival (RFS) (HR = 1.57, 95% CI = 1.34-1.84, p < 0.001). It also correlated with a higher risk of lymph node metastasis (OR = 1.97, 95% CI = 1.52-2.55, p < 0.001), but showed no significant associations with vascular invasion, tumor differentiation, or perineural invasion.Conclusion: Preoperative SII is an effective prognostic predictor for BTC, where elevated levels indicate poorer survival outcomes and increased likelihood of vascular and lymph node involvement.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and prognostic value of deregulated miR-493-5p in children with severe pneumonia. miR-493-5p失调控在儿童重症肺炎中的诊断和预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-20 DOI: 10.1080/17520363.2026.2713990

Lili Liu, Lei Han, Huan Zhao, Liying Wang

{"title":"Diagnostic and prognostic value of deregulated miR-493-5p in children with severe pneumonia.","authors":"Lili Liu, Lei Han, Huan Zhao, Liying Wang","doi":"10.1080/17520363.2026.2713990","DOIUrl":"https://doi.org/10.1080/17520363.2026.2713990","url":null,"abstract":"Background: Mounting research has proven that microRNAs (miRNAs) exert critical regulatory functions in the pathological progression of pediatric pneumonia.Aims: To investigate the expression levels and clinical significance of miR-493-5p in children with severe pneumonia.Methods: A total of 125 children diagnosed with severe pneumonia, 100 children with mild pneumonia, and 100 healthy children as normal controls were enrolled in this study. RT-qPCR was adopted to quantify serum miR-493-5p expression levels. ROC curves were plotted to assess its diagnostic efficiency; Kaplan-Meier survival analysis combined with Log-rank test evaluated 28-day prognostic value. LPS-stimulated MRC-5 human lung fibroblast cell model was constructed for in vitro functional experiments to uncover the underlying molecular mechanism of miR-493-5p.Results: Serum miR-493-5p expression was markedly elevated in children with severe pneumonia. ROC analysis validated that serum miR-493-5p possessed satisfactory accuracy for distinguishing severe pneumonia from mild cases. miR-493-5p may target Interferon Regulatory Factor 1 (IRF1) to affect the functions and inflammatory responses of cells in the pneumonia model.Conclusions: Serum miR-493-5p level has significant diagnostic and prognostic value in children with severe pneumonia.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral biomarkers in rheumatoid arthritis-associated interstitial lung disease: a review of roles and candidates. 外周生物标志物在类风湿关节炎相关间质性肺疾病中的作用和候选研究综述

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-07 DOI: 10.1080/17520363.2026.2697708

Brent A Luedders, Scott M Matson, Bryant R England

引用次数: 0

Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model. 血清BDNF、PD-1、MMP-9在AECOPD中的预后价值和双轴风险模型

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-02-05 DOI: 10.1080/17520363.2026.2620351

Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen

{"title":"Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model.","authors":"Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen","doi":"10.1080/17520363.2026.2620351","DOIUrl":"10.1080/17520363.2026.2620351","url":null,"abstract":"Objectives: To investigate longitudinal changes in neuroimmune biomarkers during acute exacerbations of chronic obstructive pulmonary disease (AECOPD), their modulation by standard therapy, and prognostic implications for 90-day outcomes.Materials and methods: In a prospective cohort, 266 hospitalized AECOPD patients were stratified into worsened (n = 53) and stable (n = 213) groups; 80 healthy individuals served as controls. Serum levels of BDNF, PD-1, MMP-9, and cytokines were assessed at admission (T1), pre-discharge (T2), and 90-day follow-up (T3). Mixed-effects models evaluated biomarker trajectories, while Cox regression examined correlations with clinical outcomes.Results: Compared with controls, AECOPD patients exhibited higher IL-6, TNF-α, PD-1, and MMP-9, alongside reduced BDNF and IL-10. Stable patients demonstrated partial biomarker normalization, whereas worsened patients retained a pro-inflammatory profile. Corticosteroids and antibiotics attenuated cytokine elevations, and oxygen therapy facilitated BDNF recovery. Low BDNF and high MMP-9 predicted spirometric decline, while elevated PD-1 and MMP-9 were associated with increased 90-day readmission risk. A dual-axis model incorporating neurotrophic and immune exhaustion markers outperformed GOLD classification for risk prediction.Conclusions: Neuroimmune biomarkers capture recovery heterogeneity in AECOPD. The proposed dual-axis model improves prognostic accuracy and may inform personalized management strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"569-582"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal biomarker profiling in varicocele predicts surgical recovery. 精索静脉曲张的多模式生物标志物分析预测手术恢复。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI: 10.1080/17520363.2026.2686307

Lei Zheng, Zhiming Wen, Letian Wei, Tao Jiang

{"title":"Multimodal biomarker profiling in varicocele predicts surgical recovery.","authors":"Lei Zheng, Zhiming Wen, Letian Wei, Tao Jiang","doi":"10.1080/17520363.2026.2686307","DOIUrl":"10.1080/17520363.2026.2686307","url":null,"abstract":"Aims: Varicocele (VC) remains a leading correctable cause of male infertility, yet standardized multimodal biomarkers are lacking for clinical stratification and outcome prediction.Patients and methods: This prospective observational study enrolled 131 primary VC patients and 20 healthy controls, evaluating semen parameters, sperm DNA fragmentation index (DFI), testicular shear wave elastography (SWE), hormonal profiles, and inflammatory/metabolic markers.Results: VC patients showed reduced sperm progressive motility (sperm PM) (p < 0.001), elevated DFI (p = 0.002), increased abnormal sperm morphology (p < 0.001); smaller left (p = 0.002) and right (p = 0.029) testis, volume difference (p = 0.030); bilateral testicular stiffness (left p < 0.001, right p < 0.001); higher homocysteine (p = 0.001); and a lower T/E2 ratio (p = 0.030). DFI correlated negatively with sperm PM (r = -0.367, p < 0.001). Postoperative improvements were observed in sperm PM (p < 0.001), sperm morphology (p < 0.001), DFI (p < 0.001), left testicular elasticity (p < 0.001), right testicular elasticity (p < 0.001), homocysteine (p = 0.001), testosterone (p = 0.011), and the T/E2 ratio (p = 0.011). Preoperative DFI (OR =1.045), abnormal sperm morphology rate (OR =1.604), and sperm PM (OR =0.951) independently predicted complete semen parameter recovery at 3 months (AUC = 0.863, sensitivity 67.9%, specificity 89.5%).Conclusion: An integrated multimodal framework incorporating imaging, molecular, and functional biomarkers facilitates prognostic stratification and personalized management of varicocele-associated infertility.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"583-594"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial sST2 dynamics after transcatheter tricuspid valve intervention: a candidate biomarker of biological response. 经导管三尖瓣干预后sST2序列动态：生物反应的候选生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-03 DOI: 10.1080/17520363.2026.2697762

Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter

{"title":"Serial sST2 dynamics after transcatheter tricuspid valve intervention: a candidate biomarker of biological response.","authors":"Christoph Edlinger, Johannes Schlegl, Marwin Bannehr, Michael Lichtenauer, Tanja Kücken, Alexander Krutz, Vera Paar, Michael Neuß, Anja Haase-Fielitz, Christian Butter","doi":"10.1080/17520363.2026.2697762","DOIUrl":"10.1080/17520363.2026.2697762","url":null,"abstract":"Aims: Patients undergoing transcatheter tricuspid valve intervention (TTVI) frequently present with advanced right-sided heart failure and multiorgan dysfunction, limiting the interpretability of conventional biomarkers such as natriuretic peptides. Soluble suppression of tumorigenicity 2 (sST2), a marker of myocardial strain, inflammation, and fibrosis, may provide complementary insight into biological response following intervention.Patients & methods: In this prospective single-center cohort study, 135 patients undergoing TTVI were included. Plasma concentrations of sST2 were measured at baseline, discharge, 3 months, and 12 months. Longitudinal changes were analyzed using non-parametric repeated measures testing and compared with established biomarkers, including GDF-15, suPAR, H-FABP, NT-proANP and supplementary NT-proBNP analyses.Results: sST2 demonstrated a distinct biphasic trajectory, with an early increase at discharge followed by a significant decline at 3 and 12 months below baseline levels (overall p < 0.001). This pattern remained consistent in sensitivity analyses. In contrast, GDF-15, suPAR, H-FABP, NT-proANP, and supplementary NT-proBNP analyses showed heterogeneous longitudinal profiles without the sustained treatment-related trajectory observed for sST2.Conclusions: In patients undergoing TTVI, sST2 exhibits a characteristic longitudinal profile reflecting biological response to intervention. These findings identify sST2 as a candidate dynamic biomarker and support a framework distinguishing prognostic baseline-risk biomarkers from dynamic treatment-response biomarkers.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"613-620"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory burden index and prognostic outcomes in gastrointestinal cancer: a meta-analysis. 胃肠道肿瘤的炎症负担指数和预后：一项荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-06 DOI: 10.1080/17520363.2026.2712925

Jia-Run Zhang, Rong Qin, Xi Zhang, Xin-Rui Hu

{"title":"Inflammatory burden index and prognostic outcomes in gastrointestinal cancer: a meta-analysis.","authors":"Jia-Run Zhang, Rong Qin, Xi Zhang, Xin-Rui Hu","doi":"10.1080/17520363.2026.2712925","DOIUrl":"10.1080/17520363.2026.2712925","url":null,"abstract":"Background: The Inflammatory Burden Index (IBI) has been identified as a significant prognostic factor in various gastrointestinal (GI) malignancies. However, despite extensive research, its prognostic value remains inconsistent. To clarify this association, we conducted a systematic meta-analysis following rigorous methodological standards.Methods: A comprehensive literature search was performed across PubMed, Web of Science, Embase, Scopus, and Cochrane databases. Ultimately, nine studies were included, covering multiple gastrointestinal cancer subtypes.Results: Our analysis demonstrated that an elevated IBI was significantly associated with poorer overall survival (OS) (HR = 2.14, 95% CI: 1.38-3.31, p = 0.001), disease-free survival (DFS) (HR = 1.75, 95% CI: 1.35-2.26, p < 0.001), and recurrence-free survival (RFS) (HR = 2.15, 95% CI: 1.59-2.92, p < 0.001). Furthermore, IBI levels were significantly correlated with several key clinicopathological factors including age, tumor size, lymph node metastases, lymph-vascular invasion, and neoadjuvant chemotherapy.Conclusion: This meta-analysis suggests that elevated IBI might be a robust predictor for poor survival in GI cancer patients and correlates closely with advanced disease features including larger tumor size, lymph node metastases, and lymph-vascular invasion. These findings underscore IBI as a clinically relevant prognostic biomarker for GI malignancies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"715-722"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness. 甲状腺体积作为PCOS女性早期动脉粥样硬化的标志：与颈动脉内膜-中膜厚度的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-02-16 DOI: 10.1080/17520363.2026.2631622

Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç

{"title":"Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness.","authors":"Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç","doi":"10.1080/17520363.2026.2631622","DOIUrl":"10.1080/17520363.2026.2631622","url":null,"abstract":"Aim: This study aimed to evaluate the determinants of thyroid volume (TV) in euthyroid women with polycystic ovary syndrome (PCOS) and to assess the association between TV and cardiovascular risk, with a particular focus on carotid intima - media thickness (CIMT).Methods: This cross-sectional study included 100 participants (46 women with PCOS and 54 age-matched healthy controls). Only euthyroid participants were enrolled. TV was measured by ultrasonography, and CIMT was evaluated as a marker of early atherosclerosis. Biochemical markers were recorded. Multiple regression and receiver operating characteristic (ROC) analyses were performed.Results: Women with PCOS had significantly higher TV compared to controls [13.4 ml (IQR: 9.8-17.4) vs. 11.3 ml (IQR: 9.6-12.9), p = 0.041]. TV was positively correlated with BMI (r = 0.485, p < 0.001), waist circumference (r = 0.419, p = 0.004), and HOMA-IR (r = 0.406, p = 0.005). CIMT was independently predicted by total testosterone (β = 0.296, p = 0.040), LH/FSH ratio (β = -0.398, p = 0.005) and TV (β = 0.306, p = 0.036). ROC analysis showed that TV moderately predicted elevated CIMT (AUC = 0.68; optimal cutoff =14.5 mL).Discussion: TV was independently associated with CIMT in euthyroid women with PCOS, suggesting that thyroid morphology may serve as a complementary, noninvasive marker of early atherosclerotic changes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"557-567"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification and early diagnostic markers of Primary hepatic carcinoma: a comprehensive review. 原发性肝癌的分类及早期诊断指标综述。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-08 DOI: 10.1080/17520363.2026.2697759

Xinyao Liu, Lin Gong, Weiran Kong, Jie Kong, Yang Zhang, Chuantao Yuan, Shuai Chen

引用次数: 0