Biomarkers in medicine最新文献

mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC. mSEPT9在III期CRC的NAT应答、MRD评估和复发预测方面优于CEA。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-08 DOI: 10.1080/17520363.2025.2489919

Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang

{"title":"mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC.","authors":"Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang","doi":"10.1080/17520363.2025.2489919","DOIUrl":"https://doi.org/10.1080/17520363.2025.2489919","url":null,"abstract":"Aims: This study aimed to investigate the capability of methylated SEPT9 (mSEPT9) assay in assessing the neoadjuvant therapy (NAT) response,the minimal residual disease (MRD) and predicting the recurrence of stage III colorectal cancer (CRC).Materials & methods: We prospectively recruited 124 stage III CRC patients. All patients received pre-surgical NAT and subsequent curative surgery, and were followed up to 627 days. Blood samples were collected before NAT, after NAT and after surgery. Measurements of mSEPT9 and CEA were performed.Results: mSEPT9 exhibited a positive detection rate (PDR) of 82.6% for stage III CRC, significantly higher than that of the carcinoembryonic antigen (CEA) (60.3%,p < 0.001). The levels of mSEPT9 and CEA significantly decreased after NAT. This can be observed for patients with complete response (CR), partial response (PR), stable disease (SD) and tumor regression grade (TRG) 1-3 in mSEPT9 and patients with PR, SD and TRG 2-3 in CEA. Stepwise percentage decrease of marker levels was more prominent in mSEPT9 than in CEA following NAT and surgical treatment. Kaplan-Meier analysis suggested that mSEPT9 significantly stratified the patient recurrence-free survival(RFS) before NAT, after NAT and after surgery. In contrast, CEA significantly stratified RFS after NAT and after surgery, while CEA levels before NAT did not significantly stratify RFS.Conclusion: mSEPT9 exhibits better applicability than CEA in assessment in terms of patient coverage, sensitivity and the pre-NAT recurrence prediction.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration. NDRG1/2作为宫颈癌预后预测生物标志物及其与免疫浸润的相关性

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-07 DOI: 10.1080/17520363.2025.2483495

Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang

{"title":"NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration.","authors":"Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang","doi":"10.1080/17520363.2025.2483495","DOIUrl":"https://doi.org/10.1080/17520363.2025.2483495","url":null,"abstract":"Background: Cervical cancer (CC) is a leading cause of cancer-related death in women. The N-myc down-stream regulatory gene (NDRG) family has an unclear prognostic role in CC.Methods: We analyzed NDRG mRNA and protein levels in CC using public databases. And NDRG1 expression was verified through immunohistochemistry in clinical samples. Additionally, we utilized other bioinformatics tools to analyze the correlations between NDRG and survival, as well as immune infiltration.Results: NDRG1 was elevated, and NDRG2 was reduced in CC tissues. High NDRG1 and low NDRG2/3 correlated with poorer survival and were associated with reduced immune cell infiltration, particularly CD8+ T cells. Genetic alterations in NDRG1/2/3 were primarily amplifications, while DNA hypomethylation of NDRG1 in CC tissues, particularly at specific CpG sites, was associated with prognosis. PPI and enrichment analyses implicated NDRGs in metabolic processes, HIF-1 signaling, and immune regulation, underscoring their roles in CC progression and prognosis.Conclusions: NDRG1/2 present potential as new prognostic biomarkers, shedding light on therapeutic targets for CC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing risk stratification post-myocardial infarction: prognostic value of NT-proBNP and fQRS. 增强心肌梗死后风险分层：NT-proBNP和fQRS的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17520363.2025.2473875

Ashok Kumar Pannu

引用次数: 0

PRDX-4: a novel biomarker similar to KL-6 for predicting the occurrence and progression of systemic sclerosis-ILD. PRDX-4：一种类似于KL-6的新型生物标志物，可预测系统性硬化症- ild的发生和进展。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 DOI: 10.1080/17520363.2025.2485014

Gizem Tuğçe Alp, İbrahim Vasi, Emre Alp, Aslıhan Avanoğlu Güler, Hazan Karadeniz, Özlem Gülbahar, Abdulsamet Erden, Abdurrahman Tufan, Mehmet Akif Öztürk, Berna Göker, Şeminur Haznedaroğlu, Hamit Küçük

{"title":"PRDX-4: a novel biomarker similar to KL-6 for predicting the occurrence and progression of systemic sclerosis-ILD.","authors":"Gizem Tuğçe Alp, İbrahim Vasi, Emre Alp, Aslıhan Avanoğlu Güler, Hazan Karadeniz, Özlem Gülbahar, Abdulsamet Erden, Abdurrahman Tufan, Mehmet Akif Öztürk, Berna Göker, Şeminur Haznedaroğlu, Hamit Küçük","doi":"10.1080/17520363.2025.2485014","DOIUrl":"https://doi.org/10.1080/17520363.2025.2485014","url":null,"abstract":"Aim: Lungs are among the most affected organs in systemic sclerosis (SSc), with interstitial lung disease (ILD) being a leading cause of mortality. Biomarkers are increasingly explored for predicting SSc-ILD detection and progression. This study evaluates the roles of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and peroxiredoxin-4 (PRDX-4) in diagnosing SSc-ILD and monitoring progression.Methods: A total of 89 individuals (61 SSc patients and 28 healthy volunteers) were included. SSc patients were grouped based on pulmonary function tests and high-resolution computed tomography findings to determine SSc-ILD presence. Patients with SSc-ILD were further categorized by progressive pulmonary fibrosis (PPF) presence based on 2022 guidelines. Serum KL-6, SP-D, and PRDX-4 levels were measured using the Enzyme-Linked Immuno-Sorbent Assay method.Results: Of the 61 SSc patients, 34 (55.7%) had ILD. Serum KL-6 and PRDX-4 levels were significantly higher in SSc-ILD patients (p = 0.004 and p = 0.012, respectively). KL-6, SP-D, and PRDX-4 levels were elevated in the PPF group compared to stable disease (p = 0.001). PRDX-4 showed the highest diagnostic performance for PPF (AUC: 0.936, sensitivity: 85.7%, specificity: 85%).Conclusion: KL-6 is a well-established biomarker for SSc-ILD, but PRDX-4 offers superior diagnostic accuracy, especially in identifying PPF.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer. 术前血液中性粒细胞/淋巴细胞比值、红细胞压积和纤维蛋白原预测结直肠癌预后。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1080/17520363.2025.2473310

Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen

{"title":"Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.","authors":"Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen","doi":"10.1080/17520363.2025.2473310","DOIUrl":"10.1080/17520363.2025.2473310","url":null,"abstract":"Objective: To investigate the prognostic potential of preoperative blood neutrophil to lymphocyte ratio (NLR), hematocrit (HCT) and Fibrinogen (FIB) level in patients with colorectal cancer (CRC).Methods: The data of 268 patients with CRC who underwent radical surgery from March 2013 to August 2017 in the First Affiliated Hospital of Guangzhou Medical University (Guangzhou, China) were retrospectively collected. The correlations between preoperative blood NLR, HCT and FIB level and the clinicopathologic features and prognosis were explored by Cox regression in the patients with CRC.Results: Univariate and multivariate analyses identified preoperative blood with high NLR (HR = 2.265, 95% CI: 1.437-3.570), low HCT (HR = 1.575, 95% CI: 1.010-2.454), and high FIB (HR = 1.667, 95% CI: 1.067-2.605) as independent predictors of reduced 5-year overall survival (OS). Furthermore, the patients were stratified into high (with 3 predictors), middle (with 2 predictors) and low (with 0 or 1 predictors) risk groups according to the number of the 3 independent prognostic predictors. The more independent predictors a patient has, the poorer their prognosis tends to be.Conclusions: Preoperative NLR, HCT, and FIB serve as cost-effective prognostic biomarkers in CRC. Their combination enables precise risk stratification, guiding personalized postoperative management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"251-258"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study. 作为急性肾损伤预后标志物的可溶性 Klotho 平均水平：90 天随访研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-22 DOI: 10.1080/17520363.2025.2481018

ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu

{"title":"Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study.","authors":"ShaSha Li, Yan Liang, JianHua Feng, Fang Tan, Yue Chen, LiXia Yu, QiFeng Liu","doi":"10.1080/17520363.2025.2481018","DOIUrl":"10.1080/17520363.2025.2481018","url":null,"abstract":"Background: Klotho is highly expressed in the kidney and confers pleiotropic kidney protective effects. This study aimed to assess the soluble average Klotho level and its relationship to renal function and outcomes in participants with acute kidney injury (AKI).Methods: We recruited 102 participants with AKI and 30 healthy controls (HCs). For patients with AKI, serum soluble (sKlotho) levels upon admission to and discharge from hospital were measured to assess the relationship between sKlotho level and kidney function. Individuals with AKI were followed up for 90 days to determine the association between their average sKlotho level and short-term AKI outcomes.Results: The baseline sKlotho level in individuals with AKI at admission was significantly lower than that in HCs. For individuals with AKI, the sKlotho level was significantly lower in stage 3 than in stage 1 or 2. The sKlotho level was restored along with renal function improvement at discharge. During follow-up, a lower average, but not baseline, sKlotho level, or average sKlotho/creatinine ration predicted more AKI clinical outcomes.Conclusion: The sKlotho level decreased significantly with kidney injury and represented severity. The average sKlotho level inversely correlated with detrimental kidney outcomes and may have potential diagnostic and predictive roles in AKI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"243-250"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index. 急性冠脉综合征全因死亡率的新指标：CALLY指数。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483159

Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay

{"title":"A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index.","authors":"Barış Güven, Muhammed Furkan Deniz, Neziha Aybüke Geylan, Barkın Kültürsay, Ayça Dönmez, Zübeyir Bulat, Ömer Burak Gül, Melike Kaya, Veysel Oktay","doi":"10.1080/17520363.2025.2483159","DOIUrl":"10.1080/17520363.2025.2483159","url":null,"abstract":"Aims: This study aimed to identify the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting all-cause mortality in acute coronary syndrome (ACS) patients who have undergone primary percutaneous coronary intervention (pPCI) for revascularization.Materials and methods: 505 patients who presented with ACS and underwent pPCI were retrospectively included in this single center study. CALLY index and other five prognostic scores were calculated. The median follow-up was 40 months. All-cause mortality was defined as the primary endpoint.Results: The median age of the patients was 59 years, 23.4% were female. The CALLY index was categorized into low (<0.7) and high (≥0.7). Age (p = 0.038), concomitant atrial fibrillation (p = 0.023), previous CABG (p = 0.001), ACE-I/ARB/ARNI use (p = 0.015), diuretic use (p = 0.021), and a low-CALLY index (p < 0.001) were identified as independent predictors of all-cause mortality in multivariate cox regression analysis. When compared to other prognostic scores according to AUC in ROC analysis, the CALLY index demonstrated the best ability to predict all-cause mortality. Additionally, patients with a high-CALLY index exhibited significantly better survival outcomes compared to those with a low-CALLY index (log-rank:p < 0.001).Conclusions: CALLY index can be utilized as a novel prognostic score for predicting all-cause mortality in ACS patients who have undergone pPCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"287-294"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients. HE4水平与非小细胞肺癌患者PET代谢参数的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1080/17520363.2025.2471744

Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan

{"title":"Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients.","authors":"Yiğit Yilmaz, Mesut Melih Özercan, Burcu Ancin, Zeliha Günnur Dikmen, Meltem Cağlar Tuncali, Murat Tuncel, Serkan Uysal, Ulaş Kumbasar, Erkan Dikmen, Rıza Doğan","doi":"10.1080/17520363.2025.2471744","DOIUrl":"10.1080/17520363.2025.2471744","url":null,"abstract":"Aim: To investigate the relationship between serum human epididymis protein 4 (HE4) levels and metabolic parameters of positron emission tomography (PET) imaging in patients with lung cancer.Methods: Sixty non-small cell lung cancer (NSCLC) patients were included in this prospective study. Demographic information, smoking status, comorbid pathologies, preoperative HE4 levels, PET imaging metabolic parameters, disease stage and histopathology were recorded.Results: Significant positive correlations between serum HE4 levels and all the metabolic parameters were observed (p < 0.05). In univariate regression analyses, it was observed that high serum HE4 levels could indicate tumor be squamous cell carcinoma (SCC) (p = 0.029), advanced T stage (p = 0.041), and have high maximum standart uptake value (SUVmax) (p = 0.017).Conclusion: Serum HE4 levels can be used as a biomarker to predict tumor burden and metabolic activity for NSCLC patients. Although sufficient per power analysis, this study may have benefited from further expansion, and by patient heterogeneity in TNM stage and tumor histology, potentially affecting the assessment of parameter relationships.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"259-265"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk. 冠状动脉扩张预测：Intermountain风险评分在识别危险患者中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1080/17520363.2025.2483158

Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan

{"title":"Coronary artery ectasia prediction: the role of the Intermountain Risk Score in identifying patients at risk.","authors":"Şahhan Kilic, Süha Asal, Mert Babaoğlu, Samet Yavuz, Mohaddeseh Davoudi Bilehsavar, Hatice Altınışık, Yusuf Turan Gül, Mustafa Oğuz, Selami Doğan, Ahmet Lütfullah Orhan","doi":"10.1080/17520363.2025.2483158","DOIUrl":"10.1080/17520363.2025.2483158","url":null,"abstract":"Aims: This study evaluates the association between the Intermountain Risk Score (IMRS) and coronary artery ectasia (CAE) to determine its predictive value.Materials & methods: A retrospective study was conducted at a tertiary hospital from January 2019 to January 2024. A total of 446 patients (226 with CAE, 220 controls) were included. Clinical, laboratory, and angiographic data were analyzed. IMRS was calculated based on routine demographic and laboratory parameters. Statistical analyses included logistic regression and receiver operating characteristic (ROC) curve analysis.Results: Patients with CAE had significantly higher IMRS scores (p = 0.011) and were more likely to fall into high-risk IMRS categories (p = 0.002). Smoking (HR: 3.744, p = 0.045), mean corpuscular volume (HR: 1.105, p = 0.019), and IMRS color category (HR: 5.255, p = 0.016) were independent predictors. ROC analysis showed an AUC of 0.617 for IMRS score and 0.627 for IMRS color category.Conclusions: IMRS is a significant predictor of CAE and may serve as a practical risk stratification tool. Higher-risk patients could benefit from closer monitoring and targeted interventions. Further validation in prospective studies is needed.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"295-304"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome. TyG指数在预测急性冠状动脉综合征后左室低射血分数中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1080/17520363.2025.2485017

Ozlem Ozbek, Erdal Belen

{"title":"The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.","authors":"Ozlem Ozbek, Erdal Belen","doi":"10.1080/17520363.2025.2485017","DOIUrl":"10.1080/17520363.2025.2485017","url":null,"abstract":"Aims: This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.Methods & results: This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (p = 0.004), diabetes mellitus (p = 0.017), previous coronary artery disease (CAD) (p < 0.001), ST-elevation myocardial infarction (STEMI) (p < 0.001) and high (≥4.95) TyG index (p < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (p = 0.031), previous CAD (p = 0.001), peripheral artery disease (p = 0.038), renal diseases (p = 0.011), STEMI (p < 0.001) and high (≥5.10) TyG index (p < 0.001).Conclusions: The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"267-275"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0