Biomarkers in medicine最新文献

The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction. 血浆免疫蛋白酶体预测st段抬高型心肌梗死冠状动脉侧支循环的价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-19 DOI: 10.1080/17520363.2025.2520158

Zhao Ma, Meichen Sun, Baoen Zhang, Yifei Nie, Chenchen Tu, Xin Zhao, Huihua Li, Dongfeng Zhang, Xiantao Song, Hongjia Zhang

{"title":"The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction.","authors":"Zhao Ma, Meichen Sun, Baoen Zhang, Yifei Nie, Chenchen Tu, Xin Zhao, Huihua Li, Dongfeng Zhang, Xiantao Song, Hongjia Zhang","doi":"10.1080/17520363.2025.2520158","DOIUrl":"https://doi.org/10.1080/17520363.2025.2520158","url":null,"abstract":"Objective: The immunoproteasome is linked to endothelial function and may act as a proangiogenic factor. This study explored its predictive value for coronary collateral circulation (CCC) in ST-elevation myocardial infarction (STEMI) patients.Methods: We enrolled 252 STEMI patients from April 2021 to April 2024. Plasma levels of LMP2, LMP7, and PSMB10 were measured using ELISA. ROC curves assessed predictive ability for good CCC. Univariate and multivariate logistic regression analyses identified predictors, and restricted cubic spline (RCS) analysis evaluated the dose-response relationship. Subgroup analysis was also conducted.Results: Patients with good CCC had significantly higher plasma levels of immunoproteasome components. Among them, LMP7 showed the best predictive value (AUC = 0.732), with an optimal cut-off of 3.824 ng/mL. Multivariate logistic regression confirmed LMP7 ≥3.824 ng/mL as an independent predictor for good CCC [OR = 7.914 (4.127-15.174)]. RCS analysis showed a J-shaped association: the odds of good CCC increased notably when LMP7 exceeded 3.824 ng/mL. Subgroup analyses supported these findings.Conclusion: Higher plasma immunoproteasome levels, especially LMP7 ≥3.824 ng/mL, were independently associated with good CCC in STEMI patients, suggesting its potential role as a biomarker of collateral development.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis. 基于生物信息学的hsa-miR-4651和hsa-miR-608作为诊断矽肺的新型生物标志物的预测。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-19 DOI: 10.1080/17520363.2025.2520160

Jing Wu, Yimin Shi, Cuiyun Zuo, Yaping Xu, Ying Wu, Haiyan Gong, Yanyan Ke, Xue Yi

引用次数: 0

Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing. 促氧化-抗氧化平衡作为死亡率的预测因子：来自Neyshabur衰老纵向研究的发现。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-18 DOI: 10.1080/17520363.2025.2521253

Seyed Reza Mirhafez, Zeinab Shateri Amiri, Atena Mansouri, Saeed Mohammadian Haftcheshmeh, Peyman Habibi, Fatemeh Abdollahi, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

{"title":"Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing.","authors":"Seyed Reza Mirhafez, Zeinab Shateri Amiri, Atena Mansouri, Saeed Mohammadian Haftcheshmeh, Peyman Habibi, Fatemeh Abdollahi, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar","doi":"10.1080/17520363.2025.2521253","DOIUrl":"https://doi.org/10.1080/17520363.2025.2521253","url":null,"abstract":"Background: The aim of this study was to determine PAB levels as a predictor of all-cause and cause-specific mortality in adult and elderly subjects.Methods: The data from 386 subjects who had died during the study were age- and sex-matched to 386 subjects that remained alive, and PAB levels were compared. PAB was evaluated using a mixed enzymatic/chemical method involving simultaneous oxidation and reduction of the chromogen 3,3',5,5'-tetramethylbenzidine by prooxidants and antioxidants, respectively, leading to measurable colorimetric changes.Results: PAB levels showed an increased risk of mortality (OR: 1.018; 95%CI: 1.010-1.025, p < 0.001) for each unit increase of PAB (per SD increase). When divided into quartiles, the PAB value was significantly higher for all-cause mortality in quartiles 2,3 and 4 compared with quartile 1 (PAB <34.95). Using uni & multivariate conditional logistic regression with multiple adjustments, the PAB value remained significantly different for all-cause mortality. The result of the cause-specific mortality analysis showed that the mean PAB was highest in COVID-19 infection and the respiratory diseases, and lowest in death caused by cardiovascular diseases (p < 0.05).Conclusions: Increasing PAB levels were significantly associated with increasing all-cause mortality suggesting that PAB measurement may have utility in indicating disease severity and have differential prognostic value in acute and chronic clinical scenarios.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality. 血清白蛋白的表型特异性动态及其对败血症死亡率的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-18 DOI: 10.1080/17520363.2025.2521251

Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann

{"title":"Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality.","authors":"Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann","doi":"10.1080/17520363.2025.2521251","DOIUrl":"https://doi.org/10.1080/17520363.2025.2521251","url":null,"abstract":"Aims: To assess the prognostic value of serial serum albumin measurements in septic patients, with a focus on different clinical phenotypes.Methods: We conducted a prospective observational study involving 254 patients with sepsis admitted to an Intermediate Care Unit in Italy (September 2022-June 2024). Patients were classified into four sepsis phenotypes (α, β, γ, δ), and serum albumin levels were measured daily over five days. The primary outcome was 30-day mortality. Logistic regression, Cox models, and AUROC analysis were used to evaluate associations between albumin dynamics, phenotypes, and outcomes.Results: The δ phenotype showed the lowest mean albumin levels (2.2 g/dL) and the highest mortality (45.4%), while phenotype α had the highest albumin and lowest mortality (3.6%). Each 1 g/dL increase in albumin was associated with a 63% mortality risk reduction (HR 0.37; 95% CI: 0.24-0.56). Albumin's predictive performance was strongest in the δ phenotype (AUROC up to 0.95).Conclusion: Serial albumin monitoring may provide prognostic insights in sepsis, especially in phenotypes associated with endothelial dysfunction. These results are hypothesis-generating and may support more personalized treatment strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Syn-D study: detection of cutaneous phosphorylated alpha-synuclein in mild cognitive impairment a trial protocol. Syn-D研究：轻度认知障碍患者皮肤磷酸化α -突触核蛋白检测试验方案。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-16 DOI: 10.1080/17520363.2025.2520154

Christopher H Gibbons, Douglas Galasko, Daniel Press, Daniel Claassen, Todd Levine, Roy Freeman

{"title":"The Syn-D study: detection of cutaneous phosphorylated alpha-synuclein in mild cognitive impairment a trial protocol.","authors":"Christopher H Gibbons, Douglas Galasko, Daniel Press, Daniel Claassen, Todd Levine, Roy Freeman","doi":"10.1080/17520363.2025.2520154","DOIUrl":"https://doi.org/10.1080/17520363.2025.2520154","url":null,"abstract":"Background: Skin biopsies have >95% sensitivity and specificity to detect the presence of phosphorylated alpha-synuclein (P-SYN).Objective: To determine the frequency of cutaneous P-SYN in patients with mild cognitive impairment (MCI) due to suspected Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).Design, setting and participants: The Syn-D study is a multicenter prospective clinical trial from ~10 centers across the United States that includes patients with MCI-AD or MCI-DLB.Methods: Patients will undergo skin biopsies for detection of P-SYN and plasma biomarkers for ptau-217 to determine biomarker positivity rates at the MCI stage and will be followed longitudinally to determine final clinical diagnosis as defined by an expert panel of clinicians blinded to biomarker results.Main outcomes and measures: The co-primary outcomes include: 1) The sensitivity of skin biopsy detection of P-SYN in patients with clinical diagnoses of MCI due to DLB or AD at baseline and at 12-month follow-up 2) To report the frequency with which cutaneous deposition of P-SYN and blood-based AD biomarkers co-exist in a population of patients with MCI.Discussion: This will be the first in-vivo study to determine the co-existence of biomarkers for both diseases as a surrogate for co-pathology.Trial registration: NCT05479552.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum corin levels and functional capacity in patients with advanced heart failure. 晚期心力衰竭患者血清科林水平与功能能力的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/17520363.2025.2511473

Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar

{"title":"Association between serum corin levels and functional capacity in patients with advanced heart failure.","authors":"Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar","doi":"10.1080/17520363.2025.2511473","DOIUrl":"10.1080/17520363.2025.2511473","url":null,"abstract":"Background: Corin is a cardiac protease that plays a role in transforming pro-natriuretic peptides into their active biological forms. This study aimed to investigate the relationship between serum corin levels and functional capacity in patients with advanced heart failure.Methods: This cross-sectional study included 88 consecutive patients with LVEF (Left ventricular ejection fraction) <25% who were referred to the tertiary cardiovascular center. Serum corin levels were measured using ELISA (Enzyme-linked immunosorbent assay) prior to CPET (Cardiopulmonary exercise testing). Multivariable linear regression was used to assess the independent association between serum corin levels and peak VO₂ (Peak oxygen consumption).Results: The mean age was 51.3 ± 12.2 years, and 86.4% were male. The mean peak VO₂ was 13.6 ± 3.99 mL/min/kg and the mean serum corin level was 1.7 ± 0.82 ng/mL. In multivariable analysis, serum corin level was an independent predictor of peak VO₂ (Coefficient: 1.206, 95% CI: 0.527-1.880, p = 0.0007).Conclusion: Lower serum corin levels are independently associated with reduced functional capacity in advanced heart failure. Corin may serve as a valuable biomarker to complement CPET in clinical evaluation, risk stratification, and treatment planning.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"395-403"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis. 种族改变了microRNA单核苷酸多态性与儿童急性淋巴细胞白血病风险之间的关系：一项荟萃分析。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI: 10.1080/17520363.2025.2511466

Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy

{"title":"Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis.","authors":"Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy","doi":"10.1080/17520363.2025.2511466","DOIUrl":"10.1080/17520363.2025.2511466","url":null,"abstract":"Introduction: MicroRNA (miRNA) single nucleotide polymorphisms (miRNA-SNPs) have been associated with pediatric acute lymphoblastic leukemia (ALL). However, since the results of these individual studies have been inconsistent, we performed a meta-analysis to help establish a statistical significance for the association between miRNA-SNPs and pediatric ALL risk. We also analyzed whether they confer susceptibility across country-specific studies by using different genetic models.Methods: Articles published from 2001 to 2023 were collected from PubMed and Google Scholar databases. Through MetaGenyo, the association between miRNA- SNPs and pediatric ALL risk was calculated by pooled odds ratio [ORs] and 95% CI. A subgroup analysis of pooled ORs in country-specific studies was also performed.Results: Based on the inclusion and exclusion criteria, 14 studies were analyzed to extract data on miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915 and mir-499 rs3746444. While the pooled data analysis did not reveal any association, a subgroup analysis demonstrated country-specific differences in allele frequencies of all the four miRNAs in various genetic models, implying ethnicity-based risk.Conclusion: Our results suggested that miRNA-SNPS can still be considered as a potential risk factor to be explored in more populations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"435-449"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia. 妊娠早期中性粒细胞百分比-白蛋白比率：一种新的子痫前期预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI: 10.1080/17520363.2025.2511468

Çağlayan Biçer, Fatih Akkuş, Yusuf Dal

{"title":"First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia.","authors":"Çağlayan Biçer, Fatih Akkuş, Yusuf Dal","doi":"10.1080/17520363.2025.2511468","DOIUrl":"10.1080/17520363.2025.2511468","url":null,"abstract":"Objective: This retrospective study evaluated the predictive power of a new marker for pre-eclampsia (PE), the neutrophil percentage/albumin ratio (NPAR).Methods: A total of 399 participants consisting of 133 pregnant women diagnosed with PE and 266 healthy pregnant controls were included in the study. Data collected included demographic and obstetric history, gestational age at diagnosis, maternal hematological and biochemical parameters, first trimester neutrophil/albumin ratio (NAR) and NPAR values, and neonatal outcomes.Results: The pre-eclampsia group showed significantly higher NAR (mean: 312.30, range: 80.00-1568.00) and NPAR (mean: 3.14 ± 0.81) compared to the control group (mean NAR: 234.40, range: 78.16-725.00; mean NPAR: 2.06 ± 0.38; p = 0.001 for both). Furthermore, early-onset PE was associated with significantly higher NAR (395.00 vs. 256.23, p = 0.001) and NPAR (3.87 vs. 2.80, p = 0.001) compared to late-onset PE. For early-onset PE, NPAR showed a sensitivity of 76.19%, specificity of 92.31%, PPV of 82.05%, NPV of 89.36% and area under the curve (AUC) of 0.897, demonstrating its strong potential as an early predictor of pre-eclampsia.Conclusion: NPAR is elevated in PE compared to healthy pregnancies, demonstrating its potential as a simple yet effective biomarker for predicting PE.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"415-423"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation. 经导管主动脉瓣植入术后血清乳酸水平与住院死亡率的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI: 10.1080/17520363.2025.2517524

Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi

{"title":"The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation.","authors":"Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi","doi":"10.1080/17520363.2025.2517524","DOIUrl":"10.1080/17520363.2025.2517524","url":null,"abstract":"Background: This study assesses the influence of early hyperlactatemia after the transcatheter aortic valve implantation (TAVI) procedure on subsequent outcomes.Methods: Adult patients undergoing elective percutaneous TAVI between 2012 and 2022 in a single tertiary cardiac center were retrospectively included. Peak post-procedure lactate level within 24-h was recorded for 284 patients included in the study. The primary outcome measured was 30-day mortality.Results: 19 patients (6.6%) experienced 30-day mortality. Patients with mortality were characterized by advanced age (p = 0.022) and higher lactate levels after the procedure (5.4 ± 5.4 mmol/L vs 1.3 ± 0.6 mmol/L, p < 0.001). Post-procedure hyperlactatemia was an independent predictor of mortality (OR 3.95, 95% CI 1.35-11.60, p = 0.012). ROC analysis revealed 1.54 mmol/L as a cutoff for mortality with 85.7% specificity and 68.4% sensitivity.Conclusion: The initial 24-hour lactate levels seem to play a valuable role in predicting the likelihood of surviving during the hospital stay after the implantation procedure. Further investigation is required to ascertain the optimal strategies for managing early post-procedure hyperlactatemia in the TAVI population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"481-489"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter. 2型心肾综合征的预测因子和预后模型：一项多中心回顾性研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1080/17520363.2025.2520738

Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan

{"title":"Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter.","authors":"Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan","doi":"10.1080/17520363.2025.2520738","DOIUrl":"10.1080/17520363.2025.2520738","url":null,"abstract":"Background: Type 2 CRS is characterized by the development of renal dysfunction secondary to chronic cardiac disease. Despite its high morbidity and mortality, there is a lack of robust diagnostic tools and prognostic models to guide clinical management.Methods: This multicenter retrospective study included patients diagnosed with CRS type 2 based on the 2019 American Heart Association definition. Data were collected from electronic medical records of three hospitals between January 2021 and December 2023. Advanced statistical methods, including receiver operating characteristic (ROC) curve analysis, univariate Kaplan-Meier (KM) analysis, and multivariable Cox proportional hazards regression, were utilized to develop a nomogram for predicting patient prognosis.Results: The study included 519 patients with CRS-2. Independent predictors of adverse outcomes included elevated serum creatinine and blood urea nitrogen (BUN) levels, decreased platelet count, elevated B-type natriuretic peptide (BNP), and decreased oxygen partial pressure (PaO2). These findings suggest that close monitoring of these markers is essential in clinical practice to identify patients at high risk of adverse events early on.Conclusion: Our study provides evidence that serum creatinine, BUN, platelet count, BNP, and PaO2 are independent predictors of adverse outcomes in patients with Type 2 CRS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"491-499"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0