Biomarkers in medicine最新文献

Scientific trends in obstructive sleep apnea biological and clinical assessment indicators: a bibliometric analysis. 阻塞性睡眠呼吸暂停生物学和临床评估指标的科学趋势：文献计量学分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-08 DOI: 10.1080/17520363.2026.2671003

Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao

{"title":"Scientific trends in obstructive sleep apnea biological and clinical assessment indicators: a bibliometric analysis.","authors":"Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao","doi":"10.1080/17520363.2026.2671003","DOIUrl":"https://doi.org/10.1080/17520363.2026.2671003","url":null,"abstract":"Aims: Obstructive sleep apnea (OSA) is characterized by diverse biological and clinical disturbances, yet no study has systematically examined scientific developments related to its objective assessment measures. This study aimed to map the development, research hotspots, and emerging trends related to biological and clinical assessment indicators in OSA.Materials and methods: Publications indexed in the Web of Science Core Collection and Scopus from 2000 to 2025 were reviewed. A total of 1,793 articles were analyzed using VOSviewer, CiteSpace, the R bibliometrix package, and Python. The analysis assessed publication and citation trends, country contributions, keyword co-occurrence, and thematic evolution to map global research patterns in OSA assessment.Results: The number of publications increased steadily over time, reflecting growing research interest in multidimensional assessment approaches. Research themes have evolved from general inflammatory and metabolic markers toward more mechanistic and clinically oriented indicators, including oxidative stress pathways, circulating biomarkers, and cerebrovascular or cognitive related measures.Conclusions: Current research increasingly emphasizes integrated biological and clinical assessment frameworks for better characterization of OSA. Future studies should focus on validation, methodological standardization, and the integration of multiple assessment domains to facilitate clinical translation.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: diagnostic utility of procalcitonin for detecting bacteremia in persons who inject drugs. 响应：降钙素原检测注射吸毒者菌血症的诊断效用。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-05-06 DOI: 10.1080/17520363.2026.2671001

Ashok Kumar Pannu

引用次数: 0

Prognostic value of the Scottish inflammatory prognostic score in ST-Segment elevation myocardial infarction. 苏格兰炎性预后评分在st段抬高型心肌梗死中的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-15 DOI: 10.1080/17520363.2026.2659655

Bektas Murat, Selda Murat, Fatih Aydin

{"title":"Prognostic value of the Scottish inflammatory prognostic score in ST-Segment elevation myocardial infarction.","authors":"Bektas Murat, Selda Murat, Fatih Aydin","doi":"10.1080/17520363.2026.2659655","DOIUrl":"10.1080/17520363.2026.2659655","url":null,"abstract":"Aims: The Scottish Inflammatory Prognostic Score (SIPS), has emerged as a simple inflammation-based biomarker; however, its prognostic value in ST-segment elevation myocardial infarction (STEMI) has not been well established. This study aimed to evaluate the prognostic utility of SIPS for predicting long-term major adverse cardiac events (MACE) in STEMI patients.Materials and methods: We included 829 STEMI patients between 2018 and 2024. SIPS was categorized as low (0 points), moderate (1 point), or high risk (2 points). The primary endpoint was time-to-first MACE, defined as a composite of all-cause mortality, non-fatal myocardial infarction, stroke, or cardiovascular hospitalization, using Cox proportional hazards models, competing risk analysis, and measures of incremental discrimination.Results: During follow-up, MACE occurred in 293 patients (35.3%), with a stepwise increase across SIPS categories (23%, 40%, and 63%; p < 0.001). SIPS independently predicted MACE in multivariable analysis (HR per point: 1.62, 95% CI 1.35-1.94; p < 0.001). Discriminative performance was moderate (AUC = 0.655). SIPS remained independently associated with MACE in hierarchical multivariable and competing risk analyses and provided incremental prognostic value beyond clinical predictors.Conclusion: SIPS is an independent predictor of long-term MACE in STEMI patients after PPCI and may serve as a simple and cost-effective tool for early risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"275-284"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A meta-analysis of the clinical significance of red blood cell distribution width in chronic obstructive pulmonary disease. 慢性阻塞性肺疾病红细胞分布宽度临床意义的meta分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-17 DOI: 10.1080/17520363.2026.2659654

Yi Zeng, Zhipeng Ma, Keliang Liu, Wei Zheng, Jianli Ma, Hualing Wang, Chuantao Zhang

{"title":"A meta-analysis of the clinical significance of red blood cell distribution width in chronic obstructive pulmonary disease.","authors":"Yi Zeng, Zhipeng Ma, Keliang Liu, Wei Zheng, Jianli Ma, Hualing Wang, Chuantao Zhang","doi":"10.1080/17520363.2026.2659654","DOIUrl":"10.1080/17520363.2026.2659654","url":null,"abstract":"Background: This paper aims to elucidate the association of red blood cell distribution width (RDW) with chronic obstructive pulmonary disease (COPD) and its clinical outcomes.Methods: Systematically searched PubMed, Embase, Cochrane Library, and Web of Science for articles up to 11 October 2024, and conducted a comprehensive data integration and meta-analysis.Results: 41 articles with 19,518 participants were included. RDW was higher in COPD versus non-COPD patients (SMD = 0.63, 95% CI = 0.18 ~ 1.08); in AECOPD versus stable COPD (SMD = 0.39, 95% CI = 0.21 ~ 0.57); in COPD with complications (SMD = 0.50, 95% CI = 0.32 ~ 0.68); in deceased versus surviving patients (SMD = 0.63, 95% CI = 0.38 ~ 0.89); and in those with unfavorable outcomes (SMD = 1.21, 95% CI = 0.17 ~ 2.25). Increased RDW was linked to adverse outcomes (OR =1.32, 95% CI = 1.18 ~ 1.48) and predicted mortality (AUC = 0.68, 95% CI = 0.57 ~ 0.80) and other adverse outcomes (AUC = 0.76, 95% CI = 0.67 ~ 0.85) in COPD patients.Conclusions: RDW values differed markedly between COPD and non-COPD patients and among COPD patients of different severities and clinical outcomes, and was an independent predictor of mortality and complication risks.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"311-323"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel autoantibody panel as potential diagnostic markers for hepatocellular carcinoma. 一种新的自身抗体组作为肝细胞癌的潜在诊断标记物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-21 DOI: 10.1080/17520363.2026.2659658

Xiaodan Zhang, Yin Lu, Qian Yang, Jicun Zhu, Jiaxin Zhang, Donglin Jiang, Ling Liu, Yuqi Liu, Yue Wang, Jianxiang Shi, Keyan Wang, Peng Wang, Chunhua Song, Kaijuan Wang, Hua Ye

{"title":"A novel autoantibody panel as potential diagnostic markers for hepatocellular carcinoma.","authors":"Xiaodan Zhang, Yin Lu, Qian Yang, Jicun Zhu, Jiaxin Zhang, Donglin Jiang, Ling Liu, Yuqi Liu, Yue Wang, Jianxiang Shi, Keyan Wang, Peng Wang, Chunhua Song, Kaijuan Wang, Hua Ye","doi":"10.1080/17520363.2026.2659658","DOIUrl":"10.1080/17520363.2026.2659658","url":null,"abstract":"Aims: Hepatocellular carcinoma (HCC) represents a major global health burden. Tumor-associated autoantibodies (TAAs) represent promising biomarkers for cancer detection. This study aims to evaluate the diagnostic value of autoantibody panels in HCC.Patients and methods: Candidate antigens were identified via multi-omics screening (Gene Expression Omnibus (GEO), Gene Expression Profiling Interactive Analysis (GEPIA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Human Protein Atlas (HPA)) and validated by enzyme-linked immunosorbent assay (ELISA) in 280 HCC patients and 280 controls. Diagnostic models were constructed using eight machines learning algorithms.Results: A total of 10 TAAs were identified, with AUCs ranging from 0.610 to 0.729. Logistic regression (LR) was identified as the optimal model. The LR model predicted that the positive rate of early HCC (62.39%) was significantly higher than that of AFP (47.71%). Notably, this model demonstrated superior predictive capability for AFP-negative HCC (AUC = 0.751). Combining the LR model with AFP for diagnosis achieved a positive rate of 96.36%, significantly higher than the 64.78% positive rate obtained with AFP alone.Conclusion: This novel serum autoantibody panel serves as a valuable diagnostic biomarker. Its combination with AFP significantly reduces missed diagnoses, offering a promising strategy to optimize HCC screening.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"263-273"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of peripheral blood brain-derived neurotrophic factor (BDNF) levels with the use of technology-assisted stroke rehabilitation: a systematic review and meta-analysis. 外周血脑源性神经营养因子（BDNF）水平与技术辅助卒中康复的关联：一项系统回顾和荟萃分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.1080/17520363.2026.2659657

Rabiatul Adawiyah Mohamad Noor, Hanim Afzan Ibrahim, Wan Muhamad Amir W Ahmad, Muhammad Hafiz Hanafi, Muzaimi Mustapha, Kannan Thirumulu Ponnuraj, Nur Karyatee Kassim

{"title":"Association of peripheral blood brain-derived neurotrophic factor (BDNF) levels with the use of technology-assisted stroke rehabilitation: a systematic review and meta-analysis.","authors":"Rabiatul Adawiyah Mohamad Noor, Hanim Afzan Ibrahim, Wan Muhamad Amir W Ahmad, Muhammad Hafiz Hanafi, Muzaimi Mustapha, Kannan Thirumulu Ponnuraj, Nur Karyatee Kassim","doi":"10.1080/17520363.2026.2659657","DOIUrl":"10.1080/17520363.2026.2659657","url":null,"abstract":"Aims: Advanced rehabilitation technologies are progressively integrated into stroke rehabilitation. However, their capacity to elicit neurological benefits via neuroplasticity biomarkers, particularly brain-derived neurotrophic factor (BDNF), and their association with functional recovery remain poorly understood. This review aimed to systematically evaluate the effectiveness of technology-assisted rehabilitation on blood-based biomarkers in stroke patients, discuss their potential link to functional recovery, and quantitatively analyze BDNF through meta-analysis.Methods: We conducted a systematic review and a meta-analysis of studies published from January 2010 to July 2025. A comprehensive search was performed using PubMed, Scopus, and Cochrane Library. Screening was conducted using Rayyan software, and analysis was performed using SPSS Statistics.Results: Fifteen studies were included in the systematic review, with eight eligibles for meta-analysis. The serum BDNF subgroup presented a trend toward higher levels in the technology-assisted group (SMD = 0.44; 95% CI: -0.12 to 1.01; p = 0.13), while the plasma subgroup showed a significant decrease (SMD = -0.17; 95% CI: -1.24 to -0.18; p = 0.01).Conclusions: Technology-assisted rehabilitation may influence neural repair biomarkers, suggesting a potential role in stroke recovery. However, inconsistencies across studies, particularly short intervention durations and heterogeneous study designs, indicate the need for high-quality and longitudinal investigations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"297-310"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dynamic trajectories of serum tumor markers and survival outcomes in patients with extensive-stage small cell lung cancer: a retrospective cohort study. 大分期小细胞肺癌患者血清肿瘤标志物动态轨迹与生存结局的关联：一项回顾性队列研究

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-04-01 Epub Date: 2026-04-20 DOI: 10.1080/17520363.2026.2659653

Bin Jia, Boying Wu, Shuaiyin Chen, Youxiang Wang, Quanman Hu, Ping Li, Yanru Qin

{"title":"Association between dynamic trajectories of serum tumor markers and survival outcomes in patients with extensive-stage small cell lung cancer: a retrospective cohort study.","authors":"Bin Jia, Boying Wu, Shuaiyin Chen, Youxiang Wang, Quanman Hu, Ping Li, Yanru Qin","doi":"10.1080/17520363.2026.2659653","DOIUrl":"10.1080/17520363.2026.2659653","url":null,"abstract":"Background: Previous studies on extensive-stage small cell lung cancer (ES-SCLC) have primarily focused on serum tumor markers (STM) measurements at a single time point, overlooking the prognostic value of sequential STM monitoring.Methods: We conducted a retrospective cohort study of 253 patients with ES-SCLC and applied latent class growth mixed modeling to define trajectory groups for neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and cytokeratin 19 fragment (CYFRA21-1).Results: Overall survival (OS) and adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for mortality in the persistent-rising vs. low-stable groups were 1.19 (0.73 - 1.95), 1.58 (1.07 - 2.33), and 2.34 (1.11 - 4.92) for NSE, CEA, and CYFRA21-1, respectively. Persistent elevations of CEA (p = 0.021) and CYFRA21-1 (p = 0.026) were independent OS prognostic factors. For progression-free survival (PFS), adjusted HRs (95% CIs) were 2.27 (1.38 - 3.74), 1.22 (0.83 - 1.80), and 0.99 (0.48 - 2.05) for NSE, CEA, and CYFRA21-1, respectively, with NSE (p < 0.001) independently predicting PFS. Combined subgroups (three-low, one-high, and two-high) demonstrated significant OS and PFS stratification (p < 0.001).Conclusion: Dynamic monitoring of NSE, CEA, and CYFRA21-1 provides a valuable approach for prognostic prediction in patients with ES-SCLC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"285-295"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the neutrophil to lymphocyte ratio and clinical outcomes in cancers: a systematic review and meta-analysis. 中性粒细胞与淋巴细胞比值与癌症临床结局的关系：一项系统综述和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1080/17520363.2026.2625220

Siling Zhu, Wenliang Li, Hongte Zhang, Yusen Lin, Zisheng Chen

{"title":"Association of the neutrophil to lymphocyte ratio and clinical outcomes in cancers: a systematic review and meta-analysis.","authors":"Siling Zhu, Wenliang Li, Hongte Zhang, Yusen Lin, Zisheng Chen","doi":"10.1080/17520363.2026.2625220","DOIUrl":"10.1080/17520363.2026.2625220","url":null,"abstract":"Purpose: This meta-analysis aimed to evaluate the pan-cancer prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for risk stratification in patients with cancer.Methods: We systematically searched Embase, PubMed, Google Scholar, and the Cochrane Library. The analysis included prospective studies, randomized controlled trials (RCTs), and post-hoc RCT analyses reporting multivariate-adjusted associations between the NLR and survival outcomes.Results: Elevated NLR was significantly associated with worse overall survival (HR 1.61, 95% CI 1.44-1.80) and progression-free survival (HR 1.42, 1.27-1.59). Subgroup analyses by cancer type showed consistent associations in lung (OS-HR 2.29, 1.56-3.37; PFS-HR 1.73, 1.13-2.65), colorectal (OS-HR 1.88, 1.49-2.36; PFS-HR 1.43, 1.12-1.82), gastric (OS-HR 1.65, 1.46-1.87; PFS-HR 1.88, 1.14-3.11), and breast cancers (OS-HR 1.53, 1.27-1.83; PFS-HR 1.45, 1.29-1.64). Analysis by treatment modality revealed differential prognostic effects, including for chemotherapy (OS-HR 1.48, 1.34-1.65; PFS-HR 1.34, 1.14-1.57), immunotherapy (OS-HR 3.07, 1.65-5.71; PFS-HR 1.94, 1.12-3.36), surgery (OS-HR 1.90, 1.44-2.52), and targeted therapy plus chemotherapy (OS-HR 1.56, 1.28-1.90; PFS-HR 1.46, 1.22-1.76).Conclusion: An elevated NLR is associated with inferior clinical outcomes across multiple cancers, with the magnitude of its prognostic impact varying by treatment modality.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"251-261"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of sclerostin, RANKL, oxidized LDL, and phoenixin-14 levels in acute ischemic stroke. 硬化蛋白、RANKL、氧化LDL和凤凰素-14水平在急性缺血性脑卒中中的诊断价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-13 DOI: 10.1080/17520363.2026.2641471

Derya Öztürk, Fatih Özcelik, Bedriye Müge Sönmez, Ertuğrul Altınbilek, Ayşe Beyza Bekgöz, Serpil Bulut, Selin Çelik, Adem Melekoğlu, Abuzer Coşkun, Mustafa Çalık

{"title":"Diagnostic value of sclerostin, RANKL, oxidized LDL, and phoenixin-14 levels in acute ischemic stroke.","authors":"Derya Öztürk, Fatih Özcelik, Bedriye Müge Sönmez, Ertuğrul Altınbilek, Ayşe Beyza Bekgöz, Serpil Bulut, Selin Çelik, Adem Melekoğlu, Abuzer Coşkun, Mustafa Çalık","doi":"10.1080/17520363.2026.2641471","DOIUrl":"10.1080/17520363.2026.2641471","url":null,"abstract":"Aims: Acute ischemic stroke (AIS) is a leading cause of mortality and morbidity, yet largely preventable. An urgent clinical need exists for new biomarkers that enable early, noninvasive, and accurate diagnosis, even before the incident occurs. This study aims to determine the valency of serum sclerostin (SOST), receptor activator of nuclear factor-kappa B ligand (RANKL), oxidized low-density lipoproteins (OxLDL), and phoenixin-14 in AIS.Patients and methods: A case-control study was conducted in the emergency department (ED) of a tertiary care hospital between June 2024 and September 2024, including 48 patients with AIS and 40 healthy individuals. The enzyme-linked immunosorbent assay was used to determine the levels of SOST, OxLDL, RANKL, and phoenixin-14. Diagnostic accuracy and independent associations with AIS were examined.Results: Biomarker levels were significantly higher in AIS group. SOST was the best, with an area under the curve of 0.809. A one-unit increase in SOST and OxLDL levels increased the probability of stroke by 1.418 and 1.006 times, respectively.Conclusions: SOST, OxLDL, RANKL, and phoenixin-14 May be complementary markers that warrant further validation, even though the results show an association rather than a causal relationship, suggesting they might be useful for differentiating AIS from healthy controls.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"233-240"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying predictive proteomic biomarkers of selective serotonin reuptake inhibitor treatment effect in depression. 确定选择性血清素再摄取抑制剂治疗抑郁症效果的预测性蛋白质组学生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-11 DOI: 10.1080/17520363.2026.2641467

Seungyeon Lee, Sora Mun, Yeeun Yun, Doojin Kim, Jiyeong Lee, Hee-Gyoo Kang

{"title":"Identifying predictive proteomic biomarkers of selective serotonin reuptake inhibitor treatment effect in depression.","authors":"Seungyeon Lee, Sora Mun, Yeeun Yun, Doojin Kim, Jiyeong Lee, Hee-Gyoo Kang","doi":"10.1080/17520363.2026.2641467","DOIUrl":"10.1080/17520363.2026.2641467","url":null,"abstract":"Objective: Major depressive disorder (MDD) is the most common mood disorder affecting human health. The complex pathogenesis of MDD remains poorly understood, and the heterogeneity associated with the various subtypes limits our understanding of the pathophysiological mechanisms. Antidepressants are the main treatment for depressive symptoms, with selective serotonin reuptake inhibitors (SSRIs) most commonly used; however, predictors of SSRI response and their pharmacological mechanisms remain unclear. In this study, we aimed to identify the biomarkers that can predict treatment response and efficacy of SSRIs.Methods: We compared serum protein levels between patients receiving SSRIs treatment and those who achieved remission through SSRI treatment to identify predictive biomarkers for SSRI treatment effect using a liquid chromatography-mass spectrometer.Results: Sexhormone-binding globulin(SHBG) level was high in patients who achieved remission after SSRItreatment and was substantially different from that in patients with depression who received treatment without remission.Conclusion: SHBG may serve as a predictive biomarker of SSRI treatment response and may help elucidate the molecular mechanisms of SSRI therapy in MDD, including the interplay between sex-hormone regulation and immune - inflammatory pathways.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"223-231"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0