Biomarkers in medicine最新文献

Expression of MCCC2 in glioma cells and preliminary verification of poor prognosis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-04 DOI: 10.1080/17520363.2025.2473131

Cheng'ao Feng, Yu Fan, Hongwei Gao, Bowen Zhang, Xiaojie Lu

{"title":"Expression of MCCC2 in glioma cells and preliminary verification of poor prognosis.","authors":"Cheng'ao Feng, Yu Fan, Hongwei Gao, Bowen Zhang, Xiaojie Lu","doi":"10.1080/17520363.2025.2473131","DOIUrl":"10.1080/17520363.2025.2473131","url":null,"abstract":"Aims: This study mainly explored the regulatory role and mechanism of MCCC2 in GBM.Methods: This study verified the expression in clinical samples and GBM cell lines. CCK-8 and cell cloning experiments, flow cytometry, scratch experiments and Transwell chamber experiments were used to detect the effects of MCCC2 expression on proliferation, apoptosis, migration and invasion of GBM cells.Results: A reduction in MCCC2 expression could significantly lower the protein levels of ERK, decrease p-ERK levels, and inhibit ERK phosphorylation. Ulixertinib, an ERK inhibitor, was shown to hinder the proliferation, migration, and invasion of GBM cells and counteract the regulatory impact of MCCC2 overexpression on GBM cells.Conclusions: This investigation revealed that suppressing MCCC2 expression impedes the proliferation, migration, and invasion of GBM cells and promotes GBM cell apoptosis by curtailing ERK expression and phosphorylation. This discovery implies that MCCC2 might serve as a potential biological target for anti-GBM therapy, laying the groundwork for future research in this field.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-04 DOI: 10.1080/17520363.2025.2473310

Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen

{"title":"Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.","authors":"Bing Luo, Kai Zhang, Ze-Kun Jiang, Ying-Kang Xie, Yi-Xiang Wu, Rong-Chang Wang, Jiong-Qiang Huang, Jing-Song Chen","doi":"10.1080/17520363.2025.2473310","DOIUrl":"https://doi.org/10.1080/17520363.2025.2473310","url":null,"abstract":"Objective: To investigate the prognostic potential of preoperative blood neutrophil to lymphocyte ratio (NLR), hematocrit (HCT) and Fibrinogen (FIB) level in patients with colorectal cancer (CRC).Methods: The data of 268 patients with CRC who underwent radical surgery from March 2013 to August 2017 in the First Affiliated Hospital of Guangzhou Medical University (Guangzhou, China) were retrospectively collected. The correlations between preoperative blood NLR, HCT and FIB level and the clinicopathologic features and prognosis were explored by Cox regression in the patients with CRC.Results: Univariate and multivariate analyses identified preoperative blood with high NLR (HR = 2.265, 95% CI: 1.437-3.570), low HCT (HR = 1.575, 95% CI: 1.010-2.454), and high FIB (HR = 1.667, 95% CI: 1.067-2.605) as independent predictors of reduced 5-year overall survival (OS). Furthermore, the patients were stratified into high (with 3 predictors), middle (with 2 predictors) and low (with 0 or 1 predictors) risk groups according to the number of the 3 independent prognostic predictors. The more independent predictors a patient has, the poorer their prognosis tends to be.Conclusions: Preoperative NLR, HCT, and FIB serve as cost-effective prognostic biomarkers in CRC. Their combination enables precise risk stratification, guiding personalized postoperative management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between serum Lumican levels and myocardial fibrosis in patients with hypertrophic cardiomyopathy.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-03 DOI: 10.1080/17520363.2025.2473304

Emirhan Hancıoğlu, Sevgi Özcan, Esra Dönmez, Cemal Terzioğlu, Ayşegül Kırankaya, Aslıhan Tenekecigil, Ertugrul Okuyan, İrfan Sahin

{"title":"The relationship between serum Lumican levels and myocardial fibrosis in patients with hypertrophic cardiomyopathy.","authors":"Emirhan Hancıoğlu, Sevgi Özcan, Esra Dönmez, Cemal Terzioğlu, Ayşegül Kırankaya, Aslıhan Tenekecigil, Ertugrul Okuyan, İrfan Sahin","doi":"10.1080/17520363.2025.2473304","DOIUrl":"https://doi.org/10.1080/17520363.2025.2473304","url":null,"abstract":"Objective: Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in young individuals. Lumican, is an indicator of fibrosis. We aimed to evaluate the relation between serum Lumican levels and presence and extent of myocardial fibrosis in HCM.Methods: The patients diagnosed with HCM between June 2022 and March 2023 were enrolled consecutively in this prospective study. Age and gender-matched healthy individuals formed control group. Two groups were generated according to extent of late gadolinium enhancement (LGE) in HCM patients.Results: A total of 114 patients were enrolled. Serum Lumican, NT-proBNP levels and maximum wall thickness were revealed as independent risk factors associated with LGE. A cut-off value of 9.06 for Lumican was associated with 67.8% sensitivity and 65.5% specificity in prediction of LGE.Conclusion: Myocardial fibrosis is one of the important mechanisms in HCM pathophysiology. LGE on cardiac magnetic resonance imaging allows comprehensive evaluation of myocardial fibrosis, the support of diagnosis with a biomarker would be beneficial in clinical practice. Our study revealed that serum Lumican level is an independent predictor of severe LGE in HCM patients. Further studies with larger patient numbers may clarify the importance of Lumican in HCM pathophysiology.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel inflammatory biomarkers for discriminating vascular involvement in Behçet's syndrome: evaluating SII, SIRI, and NPAR.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-03-02 DOI: 10.1080/17520363.2025.2473312

Bahar Özdemir Ulusoy, Berkan Armağan, Esra Kayacan Erdoğan, Yüksel Maraş, İsmail Doğan, Kevser Orhan, Serdar Can Güven, Ebru Atalar, Hatice Ecem Konak, Pınar Akyüz Dağlı, Ahmet Omma, Orhan Küçükşahin, Şükran Erten, Hakan Babaoğlu

{"title":"Novel inflammatory biomarkers for discriminating vascular involvement in Behçet's syndrome: evaluating SII, SIRI, and NPAR.","authors":"Bahar Özdemir Ulusoy, Berkan Armağan, Esra Kayacan Erdoğan, Yüksel Maraş, İsmail Doğan, Kevser Orhan, Serdar Can Güven, Ebru Atalar, Hatice Ecem Konak, Pınar Akyüz Dağlı, Ahmet Omma, Orhan Küçükşahin, Şükran Erten, Hakan Babaoğlu","doi":"10.1080/17520363.2025.2473312","DOIUrl":"https://doi.org/10.1080/17520363.2025.2473312","url":null,"abstract":"Objective: This study aims to investigate discriminatory ability of the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Neutrophil Percentage-to-Albumin Ratio (NPAR), in differentiating Behçet's Syndrome (BS) organ involvements from mucocutaneous involvement.Methods: This retrospective cohort study analyzed 436 patients diagnosed with BS from 2018 to 2023. Patients were categorized into three groups based on organ involvement: vascular, only mucocutaneous, and other organ involvement. Receiver Operating Characteristic (ROC) analysis was used to evaluate the discriminatory ability (mucocutaneous vs rest, vascular vs rest). DeLong's test was used to determine statistical differences in discriminatory power between the models.Results: Out of 436, 115 patients had vascular involvement. SII, SIRI, and NPAR were notably elevated in the vascular involvement group (p < 0.001). ROC analysis revealed that, SII, SIRI and NPAR showed discriminative ability for vascular involvement with AUCs of 0.87 for SII, 0.87 for SIRI, and 0.88 for NPAR. Pairwise comparisons using DeLong's test indicated that all three models performed similarly.Conclusion: SII, SIRI, and NPAR are promising noninvasive biomarkers for predicting vascular involvement. These indices, derived from routine laboratory tests, could enhance early screening and may improve patient outcomes by enabling timely intervention.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive biomarker profiles in hematological malignancies: improving diagnosis, prognosis, and treatment. 血液恶性肿瘤的综合生物标志物图谱：改善诊断、预后和治疗。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-27 DOI: 10.1080/17520363.2025.2471745

Ali Golestan, Mohammadrasul Zareinejad, Amin Ramezani

{"title":"Comprehensive biomarker profiles in hematological malignancies: improving diagnosis, prognosis, and treatment.","authors":"Ali Golestan, Mohammadrasul Zareinejad, Amin Ramezani","doi":"10.1080/17520363.2025.2471745","DOIUrl":"https://doi.org/10.1080/17520363.2025.2471745","url":null,"abstract":"Hematological malignancies present substantial challenges in clinical practice due to their heterogeneity and complex biological profiles. In these diseases, biomarkers - measurable indicators of biological states - are indispensable for diagnosis, prognosis, and therapeutic decision-making. Emerging biomarkers are significantly improving outcomes in hematological cancers by enhancing early detection, refining prognostic assessments, enabling personalized treatment approaches, and optimizing overall patient management. This progress translates into better clinical outcomes and more effective strategies to treat and manage malignancies. The field of biomarker discovery has developed from basic morphological and cytogenetic markers to advanced molecular techniques, including polymerase chain reaction (PCR) and next-generation sequencing (NGS), which have significantly enhanced diagnostic accuracy and led to the development of targeted therapies. Additionally, the recent advent of technologies like mass spectrometry and single-cell RNA sequencing enables comprehensive molecular profiling and reveals novel biomarkers that were previously undetectable. Our aim in this manuscript is to provide a comprehensive overview of recent and novel immunohematological biomarkers, their diagnostic and therapeutic applications, and the future directions of this field.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical relevance of HRR (hemoglobin to RDW) and RAR (RDW to albumin) in pericarditis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-27 DOI: 10.1080/17520363.2025.2471743

Hatice Eyiol, Azmi Eyiol, Ahmet Taha Sahin

引用次数: 0

Prognostic value of HALP score in predicting in-hospital mortality in patients with NSTEMI.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-26 DOI: 10.1080/17520363.2025.2468144

Dogan Ilis, Ayca Arslan, Inanc Artac, Muammer Karakayali, Timor Omar, Serif Hamideyin, Hatice Taşkan, Ozcan Yagicibulut, Yavuz Karabag, Ibrahim Rencuzogullari

{"title":"Prognostic value of HALP score in predicting in-hospital mortality in patients with NSTEMI.","authors":"Dogan Ilis, Ayca Arslan, Inanc Artac, Muammer Karakayali, Timor Omar, Serif Hamideyin, Hatice Taşkan, Ozcan Yagicibulut, Yavuz Karabag, Ibrahim Rencuzogullari","doi":"10.1080/17520363.2025.2468144","DOIUrl":"https://doi.org/10.1080/17520363.2025.2468144","url":null,"abstract":"Aims: We aimed to investigate the association between the HALP score and in-hospital mortality in patients with non-ST segment myocardial infarction (NSTEMI).Materials and methods: In this retrospective study participants were divided into two groups, based on the median HALP score. Findings were compared between the groups.Results: A total of 1648 patients included. The median HALP score cutoff value was 3.87. While the low HALP score group (<3.87) included 824 patients, the high HALP score group (>3.87) included 824 patients. Patients with the low HALP score were older and had a higher prevalence of comorbidities. A HALP score ≤ 2.62 predicted in-hospital mortality with sensitivity of 72.5% and a specificity of 77.3% (area under curve 0.809), according to ROC curve analysis. In multivariate analysis, age, diastolic blood pressure, Killip Class > 1 and Syntax Score, creatinine level, LVEF and HALP Score (OR: 0.504, 95% CI: 0.415-0.613; p < 0.001) were independently associated with in-hospital mortality.Conclusions: According to the current study, the HALP score was independently associated with in-hospital mortality in patients with NSTEMI. Moreover, HALP score might be used as a predictor of in-hospital mortality in this population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NLR as prognostic biomarker for metastatic renal cell carcinoma patients treated with cytoreductive nephrectomy.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-26 DOI: 10.1080/17520363.2025.2471746

Huanrui Liu, Senlin Li, Fan Zhang, Weiyang He, Xin Gou, Xu Zhang, Yongpeng Xie

{"title":"NLR as prognostic biomarker for metastatic renal cell carcinoma patients treated with cytoreductive nephrectomy.","authors":"Huanrui Liu, Senlin Li, Fan Zhang, Weiyang He, Xin Gou, Xu Zhang, Yongpeng Xie","doi":"10.1080/17520363.2025.2471746","DOIUrl":"https://doi.org/10.1080/17520363.2025.2471746","url":null,"abstract":"Purpose: This study aimed to determine the prognostic value of preoperative Neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic renal cell carcinoma (mRCC) undergoing cytoreductive nephrectomy (CN).Methods: We retrospectively investigated the clinicopathological data of patients with mRCC from two Chinese hospitals (2008-2018). Patients were stratified and analyzed for survival prognosis using X-tile software, Kaplan-Meier curves, log-rank test, and univariate/multivariate Cox regression analyses.Results: The patients were divided into low NLR group (≤2.7) and high NLR group (>2.7) based on the optimal cutoff value of 2.7 obtained using the X-tile software, containing 137 and 93 patients, respectively. Kaplan - Meier analysis indicated that high NLR group had significantly inferior median progression-free survival (PFS) and overall survival (OS) than low NLR group (median PFS of 8.3 months vs. 17.9 months, p = 0.003 and median OS of 21.6 months vs. 45.1 months, p = 0.009). Multivariate Cox regression analysis showed that NLR was an independent prognostic factor for PFS (hazard ratio [HR], 1.4; 95% CI, 1.1-1.9; p = 0.022) and OS (HR, 1.5; 95% CI, 1.1-2.1; p = 0.015).Conclusions: Elevated preoperative NLR demonstrates significant association with poor survival in post-CN mRCC patients and may facilitate clinical decision-making.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic role of circulating cell-free DNA in schizophrenia and neuro-degenerative disorders.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-24 DOI: 10.1080/17520363.2025.2468151

Miltiadis Perdikakis, Dimosthenis Papadimitrakis, Nikitas Floros, Elias Tzavellas, Christina Piperi, Antonios N Gargalionis, Athanasios G Papavassiliou

引用次数: 0

Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-12 DOI: 10.1080/17520363.2025.2463882

Patrycja Mołek-Dziadosz, Joanna Natorska, Paweł T Matusik, Wiktoria Wojciechowska, Marek Rajzer, Renata Rajtar-Salwa, Stanisław Bartuś, Andrzej Surdacki, Krzysztof P Malinowski, Aleksandra Lenart-Migdalska, Maria Olszowska, Michał Ząbczyk

{"title":"Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.","authors":"Patrycja Mołek-Dziadosz, Joanna Natorska, Paweł T Matusik, Wiktoria Wojciechowska, Marek Rajzer, Renata Rajtar-Salwa, Stanisław Bartuś, Andrzej Surdacki, Krzysztof P Malinowski, Aleksandra Lenart-Migdalska, Maria Olszowska, Michał Ząbczyk","doi":"10.1080/17520363.2025.2463882","DOIUrl":"https://doi.org/10.1080/17520363.2025.2463882","url":null,"abstract":"Background: Atrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.Materials and methods: In 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.Results: AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.Conclusions: Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0