Biomarkers in medicine最新文献

Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis. 老年急性结石性胆囊炎患者入院时血糖异常及预后。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-06 DOI: 10.1080/17520363.2025.2501925

Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu

{"title":"Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis.","authors":"Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu","doi":"10.1080/17520363.2025.2501925","DOIUrl":"https://doi.org/10.1080/17520363.2025.2501925","url":null,"abstract":"Introduction: We investigated the potential correlation between abnormal blood glucose on admission and clinical outcomes of acute calculus cholecystitis in older patients.Areas covered: We included older patients (≥65 years) diagnosed with acute calculus cholecystitis. The first plasma glucose measurement obtained at admission was used. Overall, 280 older patients were evaluated. The results showed that ABG was significantly associated with more severe systemic inflammatory responses (elevated white blood cell count and neutrophil-lymphocyte ratio), a higher incidence of moderate to severe ACC, and the need for invasive treatment (an increased proportion of percutaneous cholecystostomy and combined surgeries). The prolonged hospital stay, 30-day readmission rate and mortality rate of patients in the ABG group were significantly increased, and the incidence of severe postoperative complications (Clavien-Dindo≥grade III) was higher. Multivariate analysis confirmed that ABG was an independent predictor of the severity of ACC (TG18 classification) and 30-day re-admission rate.Expert opinion/commentary: In older patients with acute calculus cholecystitis, abnormal blood glucose on admission is associated with worse outcomes, serving as a novel quantifiable risk criterion to guide treatment selection, particularly for high-risk older adults ineligible for early surgery.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC. mSEPT9在III期CRC的NAT应答、MRD评估和复发预测方面优于CEA。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-08 DOI: 10.1080/17520363.2025.2489919

Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang

{"title":"mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC.","authors":"Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang","doi":"10.1080/17520363.2025.2489919","DOIUrl":"10.1080/17520363.2025.2489919","url":null,"abstract":"Aims: This study aimed to investigate the capability of methylated SEPT9 (mSEPT9) assay in assessing the neoadjuvant therapy (NAT) response,the minimal residual disease (MRD) and predicting the recurrence of stage III colorectal cancer (CRC).Materials & methods: We prospectively recruited 124 stage III CRC patients. All patients received pre-surgical NAT and subsequent curative surgery, and were followed up to 627 days. Blood samples were collected before NAT, after NAT and after surgery. Measurements of mSEPT9 and CEA were performed.Results: mSEPT9 exhibited a positive detection rate (PDR) of 82.6% for stage III CRC, significantly higher than that of the carcinoembryonic antigen (CEA) (60.3%,p < 0.001). The levels of mSEPT9 and CEA significantly decreased after NAT. This can be observed for patients with complete response (CR), partial response (PR), stable disease (SD) and tumor regression grade (TRG) 1-3 in mSEPT9 and patients with PR, SD and TRG 2-3 in CEA. Stepwise percentage decrease of marker levels was more prominent in mSEPT9 than in CEA following NAT and surgical treatment. Kaplan-Meier analysis suggested that mSEPT9 significantly stratified the patient recurrence-free survival(RFS) before NAT, after NAT and after surgery. In contrast, CEA significantly stratified RFS after NAT and after surgery, while CEA levels before NAT did not significantly stratify RFS.Conclusion: mSEPT9 exhibits better applicability than CEA in assessment in terms of patient coverage, sensitivity and the pre-NAT recurrence prediction.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"359-370"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration. NDRG1/2作为宫颈癌预后预测生物标志物及其与免疫浸润的相关性

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/17520363.2025.2483495

Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang

{"title":"NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration.","authors":"Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang","doi":"10.1080/17520363.2025.2483495","DOIUrl":"10.1080/17520363.2025.2483495","url":null,"abstract":"Background: Cervical cancer (CC) is a leading cause of cancer-related death in women. The N-myc down-stream regulatory gene (NDRG) family has an unclear prognostic role in CC.Methods: We analyzed NDRG mRNA and protein levels in CC using public databases. And NDRG1 expression was verified through immunohistochemistry in clinical samples. Additionally, we utilized other bioinformatics tools to analyze the correlations between NDRG and survival, as well as immune infiltration.Results: NDRG1 was elevated, and NDRG2 was reduced in CC tissues. High NDRG1 and low NDRG2/3 correlated with poorer survival and were associated with reduced immune cell infiltration, particularly CD8+ T cells. Genetic alterations in NDRG1/2/3 were primarily amplifications, while DNA hypomethylation of NDRG1 in CC tissues, particularly at specific CpG sites, was associated with prognosis. PPI and enrichment analyses implicated NDRGs in metabolic processes, HIF-1 signaling, and immune regulation, underscoring their roles in CC progression and prognosis.Conclusions: NDRG1/2 present potential as new prognostic biomarkers, shedding light on therapeutic targets for CC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"329-339"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune biomarkers for predicting postoperative pneumonia following hip fracture surgery. 预测髋部骨折术后肺炎的免疫生物标志物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-13 DOI: 10.1080/17520363.2025.2491302

Zemin Wu, Bing Li, Wenke Zhu, JingJing Shang, Jiapei Yao, Yong Huang, Jiansong Yin, Xindie Zhou

{"title":"Immune biomarkers for predicting postoperative pneumonia following hip fracture surgery.","authors":"Zemin Wu, Bing Li, Wenke Zhu, JingJing Shang, Jiapei Yao, Yong Huang, Jiansong Yin, Xindie Zhou","doi":"10.1080/17520363.2025.2491302","DOIUrl":"https://doi.org/10.1080/17520363.2025.2491302","url":null,"abstract":"Objective: Abnormalities of lymphocyte subsets have been observed in patients with pneumonia. This study investigated the diagnostic efficiency of lymphocyte subsets in the detection of early-stage postoperative pneumonia (POP) among older patients undergoing hip fracture surgery.Methods: A total of 576 patients with hip fracture were recruited and analyzed for lymphocyte subsets on the first postoperative day.Results: The incidence of POP was 10.6% (61/576) from March 2016 to December 2023. The area under the curve for the percentage of CD8+ HLA-DR+ T cells was higher than that of CD4+ T and CD4+ CD45RA+ T cells. A high percentage of CD8+ HLA-DR+ T cells was significantly associated with an increased occurrence of POP. The positive findings remained significant after adjusting for confounding factors. Among the multiple complications, patients with diabetes tended to have higher percentages of CD8+ HLA-DR+ T cells.Conclusions: The percentage of CD8+ HLA-DR+ T cells had a good predictive value for detecting early-stage POP. Multi-center prospective studies with larger sample sizes are needed to verify this finding.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 9","pages":"341-348"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRDX-4: a novel biomarker similar to KL-6 for predicting the occurrence and progression of systemic sclerosis-ILD. PRDX-4：一种类似于KL-6的新型生物标志物，可预测系统性硬化症- ild的发生和进展。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-01 DOI: 10.1080/17520363.2025.2485014

Gizem Tuğçe Alp, İbrahim Vasi, Emre Alp, Aslıhan Avanoğlu Güler, Hazan Karadeniz, Özlem Gülbahar, Abdulsamet Erden, Abdurrahman Tufan, Mehmet Akif Öztürk, Berna Göker, Şeminur Haznedaroğlu, Hamit Küçük

{"title":"PRDX-4: a novel biomarker similar to KL-6 for predicting the occurrence and progression of systemic sclerosis-ILD.","authors":"Gizem Tuğçe Alp, İbrahim Vasi, Emre Alp, Aslıhan Avanoğlu Güler, Hazan Karadeniz, Özlem Gülbahar, Abdulsamet Erden, Abdurrahman Tufan, Mehmet Akif Öztürk, Berna Göker, Şeminur Haznedaroğlu, Hamit Küçük","doi":"10.1080/17520363.2025.2485014","DOIUrl":"10.1080/17520363.2025.2485014","url":null,"abstract":"Aim: Lungs are among the most affected organs in systemic sclerosis (SSc), with interstitial lung disease (ILD) being a leading cause of mortality. Biomarkers are increasingly explored for predicting SSc-ILD detection and progression. This study evaluates the roles of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and peroxiredoxin-4 (PRDX-4) in diagnosing SSc-ILD and monitoring progression.Methods: A total of 89 individuals (61 SSc patients and 28 healthy volunteers) were included. SSc patients were grouped based on pulmonary function tests and high-resolution computed tomography findings to determine SSc-ILD presence. Patients with SSc-ILD were further categorized by progressive pulmonary fibrosis (PPF) presence based on 2022 guidelines. Serum KL-6, SP-D, and PRDX-4 levels were measured using the Enzyme-Linked Immuno-Sorbent Assay method.Results: Of the 61 SSc patients, 34 (55.7%) had ILD. Serum KL-6 and PRDX-4 levels were significantly higher in SSc-ILD patients (p = 0.004 and p = 0.012, respectively). KL-6, SP-D, and PRDX-4 levels were elevated in the PPF group compared to stable disease (p = 0.001). PRDX-4 showed the highest diagnostic performance for PPF (AUC: 0.936, sensitivity: 85.7%, specificity: 85%).Conclusion: KL-6 is a well-established biomarker for SSc-ILD, but PRDX-4 offers superior diagnostic accuracy, especially in identifying PPF.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"349-355"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericarditis and inflammatory biomarkers. 心包炎和炎症生物标志物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1080/17520363.2025.2494498

Bülent Özlek, Süleyman Barutçu, Veysel Ozan Tanık

引用次数: 0

Evaluation of the effectiveness of C-reactive protein/albumin ratio on thrombus in patients undergoing transesophageal echo. c反应蛋白/白蛋白比值对经食管回声患者血栓的疗效评价。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-27 DOI: 10.1080/17520363.2025.2496134

Erkan Kahraman, Koray Kalenderoglu, Kivanc Keskin, Gunseli Miray Ozdemir, Melih Oz, Lale Dinc Asarcikli

{"title":"Evaluation of the effectiveness of C-reactive protein/albumin ratio on thrombus in patients undergoing transesophageal echo.","authors":"Erkan Kahraman, Koray Kalenderoglu, Kivanc Keskin, Gunseli Miray Ozdemir, Melih Oz, Lale Dinc Asarcikli","doi":"10.1080/17520363.2025.2496134","DOIUrl":"10.1080/17520363.2025.2496134","url":null,"abstract":"Background: Left atrial appendage thrombus (LAAT) is the predominant etiology of ischemic stroke in patients with atrial fibrillation (AF), and LAAT is optimally demonstrated by transesophageal echocardiography (TEE). The study aimed to assess patients with nonvalvular atrial fibrillation (NVAF) identified with thrombus using TEE compared to those without thrombus, utilizing the C-reactive protein/albumin ratio (CAR) as a sensitive biomarker.Methods: This study was conducted retrospectively at a single center with 668 patients with NVAF who underwent TEE. Patients were divided into two groups based on the presence or absence of LAAT on TEE. The levels of CAR, C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were compared.Results: CAR was identified as an independent variable in patients with thrombus detected on TEE. (OR: 12.773, CI: 6.669-24.464, p < 0.001) Albumin was shown to have the highest area under the curve (AUC) value for thrombus prediction, followed by CAR, CRP, NLR, and PLR, in that order. (AUC: 0.999 CI: 0.993-1.000; 0.977 (0.962-0.987); 0.931 (0.909-0.949); 0.600 (0.562-0.937) p < 0.001, AUC: 0.574 CI: 0.535-0.612 p: 0.014).Conclusion: Our study demonstrates that CAR serves as an independent predictor of LAAT and shows more dependability than other biomarkers such as NLR, CRP, and PLR.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 10","pages":"385-392"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of APOB (rs515135) and PCSK9 (rs505151) gene polymorphisms with CAD in the Indian population. APOB （rss515135）和PCSK9 （rs505151）基因多态性与CAD在印度人群中的关联

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-24 DOI: 10.1080/17520363.2025.2496128

Ale Eba, Syed Tasleem Raza, Irshad Ahmad Wani, Bashir Ahmad, Mohammad Abbas, Zeba Siddiqi, Sanchita Srivastava, Farzana Mahdi

{"title":"Association of APOB (rs515135) and PCSK9 (rs505151) gene polymorphisms with CAD in the Indian population.","authors":"Ale Eba, Syed Tasleem Raza, Irshad Ahmad Wani, Bashir Ahmad, Mohammad Abbas, Zeba Siddiqi, Sanchita Srivastava, Farzana Mahdi","doi":"10.1080/17520363.2025.2496128","DOIUrl":"10.1080/17520363.2025.2496128","url":null,"abstract":"Introduction: Coronary artery disease (CAD) is a multifactorial disorder influenced by both genetic and clinical risk factors. Lipid metabolism genes such as apolipoprotein B(APOB) (rs515135) and proprotein convertase subtilisin/kexin type 9 (PCSK9)(rs505151), have been associated with susceptibility to CAD. Study investigates the potential role of these genetic polymorphisms with risk of CAD in the Indian population.Materials and methods: A case-control study including 150 CAD cases and 150 controls. Angiographically proven Cases were recruited from the Cardiology Unit, Department of Medicine, Era's Lucknow Medical College. Genotyping was done using specific primers and restriction digestion; statistical analysis included t-tests, odds ratios, and haplotype analysis.Results: CAD cases(mean age 49.93 ± 9.13 years) had higher serum cholesterol and VLDL but lower systolic and diastolic BP compared to controls (mean age 56.47 ± 9.39 years). The APOB G allele showed a significant protective effect against CAD (OR: 0.431,p = 0.001).Conclusion: The APOB G allele may serve as a protective factor against CAD, highlighting its potential role in genetic screening for lower disease risk. Further large-scale studies are required to confirm these findings.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 10","pages":"371-377"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive power of ALBI score-based nomogram for 30-day mortality following transcatheter aortic valve implantation. 基于ALBI评分的nomogram经导管主动脉瓣植入术后30天死亡率预测能力

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-03-30 DOI: 10.1080/17520363.2025.2483157

Abdullah Yildirim, Omer Genc, Mert Evlice, Aslan Erdogan, Emre Pacaci, Ahmet Ozderya, Murat Gokhan Yerlikaya, Emre Sezici, Yeliz Guler, Omer Sen, Ahmet Guler, Ali Riza Akyuz, Levent Korkmaz, Ibrahim Halil Kurt

{"title":"Predictive power of ALBI score-based nomogram for 30-day mortality following transcatheter aortic valve implantation.","authors":"Abdullah Yildirim, Omer Genc, Mert Evlice, Aslan Erdogan, Emre Pacaci, Ahmet Ozderya, Murat Gokhan Yerlikaya, Emre Sezici, Yeliz Guler, Omer Sen, Ahmet Guler, Ali Riza Akyuz, Levent Korkmaz, Ibrahim Halil Kurt","doi":"10.1080/17520363.2025.2483157","DOIUrl":"10.1080/17520363.2025.2483157","url":null,"abstract":"Aim: This retrospective, multi-center study evaluates the relationships between novel liver function scoring systems - Albumin-Bilirubin (ALBI) score, EZ-ALBI, PALBI, and MELD-XI - and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). Feature importance was assessed with SHAP-values via the XGBoost-algorithm.Results: The ALBI score exhibited the strongest association with 30-day mortality after TAVI (AUC = 0.723, p < 0.001), outperforming other scores in this regard and consistently demonstrating predictive power across various subgroup populations. Higher 30-day mortality rates were observed in the higher tertiles of the ALBI score compared to the lower tertiles (log-rank p-value = 0.004). The ALBI-based nomogram (C-index = 0.81, 95% CI:0.73-0.86, p = 0 < 001) demonstrated superior predictive power for 30-day mortality post-TAVI compared to the STS (C-index = 0.71, 95% CI :0.64-0.77, p = 0 < 001). In addition, the nomogram showed a significant improvement in reclassification (69.3%, p < 0.001) and a stronger discrimination 15.2%, p < 0.001) compared to the STS. It integrates nine variables, first ALBI score (SHAP:1.165), including NYHA class (0.594), body mass index (0.510), glomerular filtration rate, creatinine, hemoglobin, gender, predilatation requirement, presence of chronic kidney disease, and providing a comprehensive risk assessment tool.Conclusion: This study exhibits the significance of liver dysfunction with AS patients and suggests incorporating liver function parameters in pre-operative risk assessments for better clinical outcomes in TAVI procedures.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"305-316"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as potential diagnostic markers for breast cancer. 循环无细胞DNA中的5-羟甲基胞嘧啶特征作为乳腺癌的潜在诊断标志物。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1080/17520363.2025.2483156

Nadire Aishan, Siwei Ju, Zhongqiu Zheng, Yongxia Chen, Qingna Meng, Qina He, Jiahang Zhang, Jiaheng Lang, Bojian Xie, Lidan Jin, Jun Shen, Yi Lu, Yangjun Cai, Feiyang Ji, Feilin Cao, Linbo Wang

{"title":"5-Hydroxymethylcytosine signatures in circulating cell-free DNA as potential diagnostic markers for breast cancer.","authors":"Nadire Aishan, Siwei Ju, Zhongqiu Zheng, Yongxia Chen, Qingna Meng, Qina He, Jiahang Zhang, Jiaheng Lang, Bojian Xie, Lidan Jin, Jun Shen, Yi Lu, Yangjun Cai, Feiyang Ji, Feilin Cao, Linbo Wang","doi":"10.1080/17520363.2025.2483156","DOIUrl":"10.1080/17520363.2025.2483156","url":null,"abstract":"Aims: Breast cancer is one of the most prevalent cancers among women, and early diagnosis is crucial in reducing the mortality rate. This study aims to identify novel, reliable, and specific biomarkers for breast cancer diagnosis using 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA).Materials and methods: We utilized the sensitive 5hmC seal method to map 5hmC profiles in cfDNA samples from 203 breast cancer patients and 60 healthy individuals. Machine learning models were applied to identify 5hmC marker signatures with high sensitivity and specificity.Results: A global loss of 5hmC was observed in the blood samples from cancer patients compared to the control group. Several specific 5hmC marker signatures were identified, providing a basis for distinguishing between tumor and healthy individuals.Conclusions: Our study offers a comprehensive understanding of genome-wide 5hmC in cfDNA from breast cancer patients, and identifies valuable epigenetic biomarkers for the minimally invasive diagnosis of breast cancer.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"317-328"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0