Biomarkers in medicine最新文献

Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study. 免疫营养指数与类风湿关节炎的疾病活动性相关：一项横断面研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-21 DOI: 10.1080/17520363.2024.2430942

Özlem Kılıç, Duygu Tecer, Muhammed Canbaş, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz

{"title":"Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study.","authors":"Özlem Kılıç, Duygu Tecer, Muhammed Canbaş, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz","doi":"10.1080/17520363.2024.2430942","DOIUrl":"https://doi.org/10.1080/17520363.2024.2430942","url":null,"abstract":"Aim: This study aimed to evaluate the relationship between immune nutrition indices and disease activity in rheumatoid arthritis (RA).Methods: The current study included a cross-sectional analysis of 90 age and gender-matched healthy controls and 116 RA patients who satisfied the 2010 American College of Rheumatology and European League Against Rheumatism categorization criteria. Patients were categorized into remission (disease activity score 28- erythrocyte sedimentation rate (DAS 28-ESR) <2.6) and active disease (DAS 28-ESR ≥2.6) groups.Results: Systemic immune-inflammatory index (SII), controlling nutritional status (CONUT), and fibrinogen-to-albumin ratio (FAR) were higher in the RA group than in controls, whereas CRP-albumin-lymphocyte ratio (CALLY) and prognostic nutrition index (PNI) were considerably lower in RA (p < 0.001). The clinical and simplified disease activity index, DAS 28-ESR had negative correlation with PNI and CALLY (p < 0.001). PNI and CALLY were independently related markers of disease activity (p < 0.001) by regression analysis. According to receiver operating characteristic curve analysis, the ideal cutoff values for the active disease are as follows: CONUT, 0.5; CALLY, 12.5, SII, 579.43, FAR, 90.43, and PNI, 40. CALLY was the most sensitive (84.06%) and specific marker (95.74%).Conclusions: CALLY and PNI may be useful prognostic markers for assessing disease activity in RA patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments. 基线甘油三酯-葡萄糖、体重指数、左心房舒张末期内径和肌酐是冠心病患者经皮冠状动脉介入治疗后肺动脉高压的独立预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-20 DOI: 10.1080/17520363.2024.2422807

Li Xie, Shilin Fu, Yuzheng Xu, Litong Ran, Jing Luo, Rongsheng Rao, Jianfei Chen, Shi-Zhu Bian, Dehui Qian

{"title":"Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments.","authors":"Li Xie, Shilin Fu, Yuzheng Xu, Litong Ran, Jing Luo, Rongsheng Rao, Jianfei Chen, Shi-Zhu Bian, Dehui Qian","doi":"10.1080/17520363.2024.2422807","DOIUrl":"https://doi.org/10.1080/17520363.2024.2422807","url":null,"abstract":"Aim: To identify the predictive role of triglyceride-glucose (TyG) index in pulmonary hypertension (PH) in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) treatment.Methods: Blood biomarkers have been measured at the cross-section of entrance. The baseline and followed-up echocardiography have been performed at both cross-sections.Results: The incidence of PH was 8.91%. The baseline myoglobin (MYO), was significantly higher among PH patients (p < 0.001). In the univariate regression, body mass index (BMI p = 0.020), left atria end-diastolic internal diameter (LAD, p = 0.083), creatinine (Cr, p = 0.005), triglyceride (TG, p < 0.001), high-density lipoprotein cholesterol (HDL-C, p = 0.056) and TyG index (p = 0.002) were potential predictors for PH. Finally, the adjusted COX regression indicated that BMI (p = 0.001), LAD (p = 0.030), Cr(p = 0.005) and TyG index (p = 0.002) were independent predictors of the onset of PH.Conclusion: Baseline TyG index, BMI, LAD, Cr level were independent predictors for PH in CAD patients after PCI treatment.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma nicotine and its metabolite as biomarkers of tobacco exposure and their relevance to pulmonary nodule. 血浆尼古丁及其代谢物作为烟草暴露的生物标志物及其与肺结节的相关性。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-20 DOI: 10.1080/17520363.2024.2422809

Na Wang, Wei Xiao, Qian Tang, Wenlei Hu, Sheng Wang, Zhihua Zhang, Fen Huang

{"title":"Plasma nicotine and its metabolite as biomarkers of tobacco exposure and their relevance to pulmonary nodule.","authors":"Na Wang, Wei Xiao, Qian Tang, Wenlei Hu, Sheng Wang, Zhihua Zhang, Fen Huang","doi":"10.1080/17520363.2024.2422809","DOIUrl":"https://doi.org/10.1080/17520363.2024.2422809","url":null,"abstract":"Aim: Explore the optimal cut-off values for plasma nicotine and its metabolites in assessing smoking status and quantify the association between individual tobacco exposure and pulmonary nodules (PNs).Materials & methods: A total of 2245 plasma samples were included for the determination of nicotine (Nic), cotinine (Cot) and trans-3'-hydroxycotinine (OHCot) concentrations. The receiver operating characteristic curve was used to determine the optimal biomarkers reflecting smoking status. Binary logistic regression, restricted cubic spline and generalized linear model were used to analyze the association of nicotine and its metabolites with PNs. Quantile g-computation was used to investigate the mixed effects between them.Results: Cot was found to be the best biomarker of self-reported active-passive smoking, with optimal thresholds of 9.06 and 1.26 ng/ml, respectively. Except for OHCot, increased concentrations of Cot, Nic, total nicotine equivalent (TNE2) and TNE3 were significantly positively associated with the risk of PNs, whereas nicotine metabolite ratio presented a negative association. The mixed effects of OHCot, Cot and Nic were associated with PNs, with an odds ratio of 1.17 and a 95% CI of 1.05-1.30.Conclusion: Nicotine and its metabolites as potential biomarkers of tobacco exposure were significantly associated with PNs.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis. 严重主动脉瓣狭窄的 TAVI 患者中 N-乙酰葡糖苷酶和肾损伤分子-1 的预后价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-18 DOI: 10.1080/17520363.2024.2429366

Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer

{"title":"Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis.","authors":"Congde Xu, Nastasia Roth, Carolin Heidel, Ute Hubauer, Stefan Wallner, Ralph Burkhardt, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla, Lars Maier, Kurt Debl, Carsten Jungbauer","doi":"10.1080/17520363.2024.2429366","DOIUrl":"https://doi.org/10.1080/17520363.2024.2429366","url":null,"abstract":"Aim: Cardiorenal syndrome (CRS) is common in severe aortic stenosis (AS). Previous studies revealed N-Acetylglucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for CRS. The study aimed to investigate the prognostic capability of NAG, KIM-1, NT-proBNP in severe AS before TAVI.Materials & methods: Plasma and urine samples were collected from 151 participants before TAVI. Long-term follow-up (median follow-up time 31 months) was conducted to assess all-cause mortality and a composite endpoint of mortality and congestive heart failure.Results: NT-proBNP was significantly elevated in classical low-flow, low-gradient AS compared to other severe AS phenotypes (p < 0.01), unlike NAG and KIM-1 (each p = n.s.). During follow-up, 40 patients (26.5%) died, and 58 patients (38.4%) reached the composite endpoint. Elevated baseline levels of NAG and KIM-1 were associated with increased risk of all-cause mortality in Kaplan-Meier analysis, like NT-proBNP (each p<0.05). NAG and STS-Score were revealed as significant predictors for all-cause mortality in multivariable COX-regression analysis (each p<0.05), unlike NT-proBNP, KIM-1, eGFR, and clinical parameters (each p=n.s.).Conclusion: Baseline NAG and, to a lesser degree, KIM-1 and NT-proBNP provide significant predictive value for all-cause mortality in patients with severe AS before TAVI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum HIF-1α, IGF-1 and IGFBP-3 correlate to recurrence and overall survival in early-stage hepatocellular carcinoma patients. 血清 HIF-1α、IGF-1 和 IGFBP-3 与早期肝细胞癌患者的复发和总生存期有关。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-18 DOI: 10.1080/17520363.2024.2421149

Shujun Ding, Wei Ding, Ye Zhang, Yunbao Chen, Hongtao Tang, Xiao Jiang, Jun Chen

引用次数: 0

Association between inflammatory markers and anemia in patients with diabetic foot ulcer. 糖尿病足溃疡患者的炎症指标与贫血之间的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-13 DOI: 10.1080/17520363.2024.2421159

Jiawei Li, Wenzhuan Chen, Xueman Wen, Xuemei Jin, Ping Zhu, Chunjie Jiang

{"title":"Association between inflammatory markers and anemia in patients with diabetic foot ulcer.","authors":"Jiawei Li, Wenzhuan Chen, Xueman Wen, Xuemei Jin, Ping Zhu, Chunjie Jiang","doi":"10.1080/17520363.2024.2421159","DOIUrl":"https://doi.org/10.1080/17520363.2024.2421159","url":null,"abstract":"Aim: Anemia of inflammation (AI) is common among patients with diabetic foot ulcers (DFU). This study aimed to investigate the specific relationship between inflammation indicators and anemia in patients with DFU.Materials & methods: This cross-sectional study was carried out among patients with DFU between 2018 and 2023. Clinical data were gathered before treatment. Restricted cubic spline regression was employed to investigate the non-linear associations between inflammation and anemia.Results: A total of 395 patients with Wagner grades 2-4 were enrolled in the study. About 63.54% of the patients with DFU had anemia which was primarily presented with normocytic hypopigmentation anemia. Elevated IL-6 levels (39.10-369 pg/ml) were significantly associated with an increased likelihood of anemia (OR = 4.84; 95% CI: 1.97-11.90). Similarly, high CRP levels (48.56-385 mg/l) were linked to a higher prevalence of anemia (OR = 5.01; 95% CI: 2.35-10.68). Furthermore, a nonlinear relationship was observed between CRP levels and anemia, suggesting that CRP values exceeding 53.889 mg/l may trigger anemia in patients with diabetic foot ulcers.Conclusion: Inflammation is identified as an independent risk factor for AI in patients with DFU. The inflammation indicators (CRP and IL-6) and anemia exhibit an L-shaped nonlinear correlation in patients with DFU.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning algorithms using the inflammatory prognostic index for contrast-induced nephropathy in NSTEMI patients. 使用炎症预后指数对 NSTEMI 患者造影剂诱发肾病进行机器学习算法。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-13 DOI: 10.1080/17520363.2024.2422810

Faysal Şaylık, Tufan Çınar, Murat Selçuk, İbrahim Halil Tanboğa

引用次数: 0

Proteomic biomarkers profiling in Pakistani pancreatic ductal adenocarcinoma population: a retrospective cohort study. 巴基斯坦胰腺导管腺癌人群的蛋白质组生物标志物分析：一项回顾性队列研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-11-07 DOI: 10.1080/17520363.2024.2416888

Saleema Mehboob Ali, Yumna Adnan, Zubair Ahmad, Tabish Chawla, Sm Adnan Ali

{"title":"Proteomic biomarkers profiling in Pakistani pancreatic ductal adenocarcinoma population: a retrospective cohort study.","authors":"Saleema Mehboob Ali, Yumna Adnan, Zubair Ahmad, Tabish Chawla, Sm Adnan Ali","doi":"10.1080/17520363.2024.2416888","DOIUrl":"https://doi.org/10.1080/17520363.2024.2416888","url":null,"abstract":"Aim: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Research in various cancers suggests that investigating target biomarkers may provide directions to precision medicine. However, expression of biomarkers varies across different populations. The biomarker profile of Pakistani patients with PDAC remains unexplored.Materials & methods: We conducted a study on 109 patients to analyze a panel of four proteins (KRAS, p53, BRCA1 and APC) using formalin-fixed paraffin-embedded tumor samples. After confirmation of diagnosis and appropriate tumor content, tissues were processed with antibody specific immunohistochemistry experiments. Subsequently, independent microscopic observation was conducted by two pathologists using scoring criteria specific for each antibody.Results: Statistical analysis showed that negative expression of p53 was significantly associated with positive expression of BRCA1 (p = 0.000) and APC (p = 0.007). The expression of BRCA1 was also found significantly associated with APC (p = 0.028). None of the protein showed association with overall survival or patient demographics. Moreover, KRAS expression was shown to be significantly associated with perineural invasion (p = 0.005).Conclusion: This is the first study that investigates protein biomarker expression in a large cohort of Pakistani PDAC patients. The findings from the study may provide directions about the population specific biomarkers and targeted therapies for these patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of systemic immune-inflammatory index in predicting contrast-induced nephropathy in non-ST-segment elevation myocardial infarction cases. 全身免疫炎症指数在预测非 ST 段抬高型心肌梗死病例造影剂诱发肾病中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-10-29 DOI: 10.1080/17520363.2024.2415284

Ozan Tezen, Mert İlker Hayıroğlu, Levent Pay, Ahmet Çağdaş Yumurtaş, Kıvanç Keskin, Tuğba Çetin, Şeyda Dereli, Hikmet Kadığoğlu, Furkan Fatih Yücedağ, Ertan Arter, Şennur Ünal Dayı

引用次数: 0

WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer. WTAP介导的m6A修饰调节NLRP3/Caspase-1/GSDMD，从而抑制化脓过程并加剧结直肠癌。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2024-10-29 DOI: 10.1080/17520363.2024.2416886

Anwei Mo, Huaiwen Wang

{"title":"WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer.","authors":"Anwei Mo, Huaiwen Wang","doi":"10.1080/17520363.2024.2416886","DOIUrl":"https://doi.org/10.1080/17520363.2024.2416886","url":null,"abstract":"Aim: Wilms' tumor 1-associating protein (WTAP), plays a part in colorectal cancer (CRC) progression. However, it is not yet known how WTAP affects cancer progression by influencing leukocyte rich repeat containing proteins (NLR) - family members 3 (NLRP3) - related inflammasomes.Materials & methods: We first validated the expression of WTAP in CRC at the tissue and cellular levels. Subsequently, by transfecting si-NC and si-WTAP into cells, we verified functions of WTAP in proliferation, invasion, migration and apoptosis of CRC cells. Finally, we analyzed the N6-methyladenosine (m6A) modification of NLRP3 by WTAP using methylated RNA immunoprecipitation (MeRIP)-qPCR technology, confirming that WTAP mediated the repression of NLRP3 inflammasome and the malignant progression of tumor cells.Results: WTAP was substantially upregulated in CRC tissues and cells. WTAP reinforced the migration, proliferation and invasion ability of CRC cells, and repressed apoptosis. Mechanistically, WTAP mediated the m6A modification of NLRP3, which suppressed the expression of NLRP3 and dampened the NLRP3/Caspase-1/GSDMD axis activation as well as pyroptosis, thereby facilitating the malignant progression of CRC.Conclusion: WTAP mediates m6A modification to modulate the repression of the NLRP3/Caspase-1/GSDMD axis in pyroptosis, reinforcing the malignant progression of CRC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0