Biomarkers in medicine最新文献

Prognostic significance of combined serum immunological HER2 and ERα36 biomarkers in estrogen receptor-positive breast cancer subtypes. 血清免疫HER2和ERα36生物标志物在雌激素受体阳性乳腺癌亚型中的预后意义

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-10-22 DOI: 10.1080/17520363.2025.2577630

Yiyang Guo, Shiru Cao, Yanli Deng, Hong Zhang

{"title":"Prognostic significance of combined serum immunological HER2 and ERα36 biomarkers in estrogen receptor-positive breast cancer subtypes.","authors":"Yiyang Guo, Shiru Cao, Yanli Deng, Hong Zhang","doi":"10.1080/17520363.2025.2577630","DOIUrl":"https://doi.org/10.1080/17520363.2025.2577630","url":null,"abstract":"Background: Breast cancer is the most common cancer among women, with rising incidence and mortality rates, posing clinical treatment challenges.Objective: To analyze the prognostic significance of serum immune HER2 and ERα36 biomarkers in estrogen receptor-positive breast cancer subtypes.Methods: Sixty-one estrogen receptor-positive breast cancer cases from Fourth Hospital of Hebei Medical University (2016-2023) were analyzed. The qPCR was used to detect the expression level of ERα36 mRNA in the sample, and ELISA was used to detect the expression of HER2 in the sample. Associations between biomarker expression, clinicopathological features, and prognosis were evaluated.Results: ERα36 mRNA expression was higher in breast cancer tissues than in adjacent tissues (p < 0.05). High ERα36 expression was associated with menopause (77.78%) and lymph node metastasis (75.00%) (p < 0.05). HER2 positivity correlated with menopause (55.56%) and lymph node metastasis (56.00%) (p < 0.05). No significant differences were found in age, reproductive history, family history, clinical stage, histologic grade, or T stage (p > 0.05). OS rates showed no significant difference, but PFS rates varied significantly (p < 0.05). Patients with high ERα36 expression in HER2-positive cases had the poorest prognosis (p < 0.05).Conclusion: ERα36 and HER2 are valuable prognostic biomarkers, with their co-expression linked to increased lymph node metastasis and poorer survival outcomes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to editor: the mean corpuscular volume (MCV) is a hematological biomarker associated with COVID-19 mortality risk. 致编辑：平均红细胞体积（MCV）是与COVID-19死亡风险相关的血液学生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-10-21 DOI: 10.1080/17520363.2025.2577465

Luis Del Carpio-Orantes, Jesús Salvador Sánchez-Díaz

引用次数: 0

Association between miRNA polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. miRNA多态性与类风湿关节炎易感性之间的关联：一项荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-10-21 DOI: 10.1080/17520363.2025.2577626

Young Ho Lee, Gwan Gyu Song

{"title":"Association between miRNA polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.","authors":"Young Ho Lee, Gwan Gyu Song","doi":"10.1080/17520363.2025.2577626","DOIUrl":"https://doi.org/10.1080/17520363.2025.2577626","url":null,"abstract":"Objective: To evaluate the association between microRNA (miRNA) polymorphisms and rheumatoid arthritis (RA) susceptibility through meta-analysis.Methods: We systematically searched MEDLINE, EMBASE, and Web of Science for case-control studies examining five miRNA polymorphisms: miR-146a rs2910164, miR-499 rs3746444, miR-196a2 rs11614913, miR-155 rs767649, and miR-149 rs2292832. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models.Results: Twenty-three studies comprising 4,303 RA patients and 5,337 controls were included. Significant associations were identified for three polymorphisms. MiR-499 rs3746444 demonstrated increased RA risk across multiple genetic models (allelic, recessive, and homozygote). MiR-146a rs2910164 showed population-specific effects, conferring protection in Arabs (OR = 0.666, 95% CI = 0.520-0.853, p = 0.001) but not in Asian or European populations. The miR-149 rs2292832 A allele exhibited strong protective effects (OR = 0.314, 95% CI = 0.215-0.458, p < 0.001). No significant associations were observed for miR-196a2 rs11614913 or miR-155 rs767649 polymorphisms.Conclusions: This meta-analysis demonstrates that miRNA polymorphisms exhibit variable associations with RA susceptibility. MiR-499 rs3746444 increases risk, while miR-146a rs2910164 and miR-149 rs2292832 provide protection, with ethnic-specific effects for miR-146a rs2910164.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of serum biomarkers as prognostic indicators in pediatric cardiac arrest: a systematic review. 血清生物标志物作为儿童心脏骤停预后指标的作用：一项系统综述。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-10-15 DOI: 10.1080/17520363.2025.2574837

Maria Magalhães de Carvalho, Marta João Silva, Maria João Baptista

{"title":"The role of serum biomarkers as prognostic indicators in pediatric cardiac arrest: a systematic review.","authors":"Maria Magalhães de Carvalho, Marta João Silva, Maria João Baptista","doi":"10.1080/17520363.2025.2574837","DOIUrl":"https://doi.org/10.1080/17520363.2025.2574837","url":null,"abstract":"Purpose: After Cardiac Arrest (CA), serum biomarkers (SB) are released to the blood in response to brain damage and, therefore, may be helpful tools to predict neurological outcome. This systematic review aims at assessing the role of SB as neurological outcome indicators after pediatric CA.Methods: A systematic literature search was performed in PubMed, Scopus, WebOfScience and Cochrane Library. All information retrieved from the selected articles was summarized in a data table.Results: Eight studies, including a total of 539 patients, were analyzed. Neurological outcomes were assessed by using the Pediatric Cerebral Performance Category (PCPC) scale in all studies except one. Eleven serum biomarkers were evaluated, with higher concentrations observed in the unfavorable outcome group at various time points. However, only one study defined a specific cutoff value. The biomarkers with the highest predictive accuracy for neurological outcomes appear to be initial levels of IL-17 and CNFT, as well as NSE and S100B.Conclusion: Following pediatric CA, SB may be helpful indicators of unfavorable neurological outcome, as they seem to appear in higher concentrations in this group. Further research is required to establish specific timepoints and cutoff values and to determine the implication of these findings in clinical practice.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-10-14 DOI: 10.1080/17520363.2025.2574787

引用次数: 0

Correlation between serum GFAP and 3-NT levels and the degree of neuronal injury in patients with glioma after surgery, and its diagnostic value. 脑胶质瘤术后患者血清GFAP和3-NT水平与神经元损伤程度的相关性及其诊断价值

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1080/17520363.2025.2559432

Jiaode Jiang, Feng Liu

{"title":"Correlation between serum GFAP and 3-NT levels and the degree of neuronal injury in patients with glioma after surgery, and its diagnostic value.","authors":"Jiaode Jiang, Feng Liu","doi":"10.1080/17520363.2025.2559432","DOIUrl":"10.1080/17520363.2025.2559432","url":null,"abstract":"Objective: To investigate the correlation between postoperative serum glial fibrillary acidic protein (GFAP) and 3-nitrotyrosine (3-NT) levels and neuronal injury severity in glioma patients.Methods: 150 glioma patients were enrolled, with clinical baseline and pathological data recorded (age, sex, etc.). Neuronal injury was assessed using the National Institutes of Health Stroke Scale (NIHSS) postoperatively, categorizing patients into mild (NIHSS 1 ~ 4, n = 54) and moderate-to-severe (NIHSS ≥5, n = 96) groups. Serum GFAP and 3-NT levels were measured three days post-surgery via ELISA. Correlations with NIHSS were analyzed with Spearman's test. Patients were also stratified by median biomarker levels. Multivariate logistic regression identified severity risk factors. Receiver operating characteristic (ROC) curves evaluated diagnostic value.Results: GFAP and 3-NT levels were higher in the moderate-to-severe group (p < 0.001) and positively correlated with NIHSS scores (GFAP: r = 0.552; 3-NT: r = 0.545). Higher biomarker levels were significantly associated with worse injury (p < 0.001). Both were independent risk factors for severity. Combining GFAP and 3-NT predicted severity significantly better than either alone (p < 0.001).Conclusion: Postoperative serum GFAP and 3-NT levels correlate positively with neuronal injury severity in glioma patients. Their combination provides high diagnostic value for assessing postoperative injury severity.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"837-846"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic valuation of MMP family members as biomarkers for pancreatic cancer: a systematic review and meta-analysis. MMP家族成员作为胰腺癌生物标志物的诊断价值：系统回顾和荟萃分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-10-17 DOI: 10.1080/17520363.2025.2571394

Mengyuan Lu, Donglin Jiang, Jiaxin Zhang, Ling Liu, Yajing Shen, Tiandong Li, Peng Wang, Jianxiang Shi, Keyan Wang, Hua Ye

{"title":"Diagnostic valuation of MMP family members as biomarkers for pancreatic cancer: a systematic review and meta-analysis.","authors":"Mengyuan Lu, Donglin Jiang, Jiaxin Zhang, Ling Liu, Yajing Shen, Tiandong Li, Peng Wang, Jianxiang Shi, Keyan Wang, Hua Ye","doi":"10.1080/17520363.2025.2571394","DOIUrl":"10.1080/17520363.2025.2571394","url":null,"abstract":"Background: There are numerous controversies surrounding the diagnosis of matrix metalloproteinases (MMPs) in pancreatic cancer (PC). Consequently, this study conducts the first comprehensive meta-analysis evaluating the diagnostic performance of MMP family members in PC, highlight potential biomarkers, and investigate sources of heterogeneity.Method: Articles on the MMP family and PC diagnosis were retrieved from PubMed and Web of Science. Diagnostic accuracy was assessed using sensitivity (SEN) and specificity (SPE). Threshold effects, heterogeneity (via meta-regression and subgroup analyses), and result robustness (via sensitivity analysis) were evaluated. Publication bias was examined using Deeks' funnel plot.Result: This meta-analysis included 48 studies from 23 articles, covering 12 types of MMP. The aggregated SEN, SPE, and area under the curve (AUC) for MMPs in diagnosing PC ranged from 0.61 to 0.76, 0.66 to 0.78, and 0.7273 to 0.8840, respectively. Meta-regression identified sample type as a major contributor to heterogeneity, with tissue-based MMPs showing markedly superior diagnostic performance compared to serum or plasma-based assays. Overall, MMPs showed potential diagnostic value, but their accuracy remains moderate and requires further validation in larger, well-designed studies.Conclusion: MMPs represent potential candidates for PC diagnosis, but current evidence is insufficient for clinical application, requiring further prospective studies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"909-919"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of inflammatory-nutritional indexes and HALP score in advanced stage NSCLC treated with first-line TKI. 炎症营养指标和HALP评分在一线TKI治疗晚期NSCLC中的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-13 DOI: 10.1080/17520363.2025.2560797

Ali Ogul, Ali Alper Solmaz, Ilhan Birsenogul, Yunus Coskun, Mahmut Bakır Koyuncu, Abdullah Evren Yetisir, Mahmut Buyuksimsek, Mert Tohumcuoglu, Mehmet Turker, Mustafa Gurbuz, Berna Bozkurt Duman, Timucin Cil

{"title":"Prognostic value of inflammatory-nutritional indexes and HALP score in advanced stage NSCLC treated with first-line TKI.","authors":"Ali Ogul, Ali Alper Solmaz, Ilhan Birsenogul, Yunus Coskun, Mahmut Bakır Koyuncu, Abdullah Evren Yetisir, Mahmut Buyuksimsek, Mert Tohumcuoglu, Mehmet Turker, Mustafa Gurbuz, Berna Bozkurt Duman, Timucin Cil","doi":"10.1080/17520363.2025.2560797","DOIUrl":"10.1080/17520363.2025.2560797","url":null,"abstract":"Aim: In metastatic Non-small cell lung cancer (NSCLC) with driver mutations, resistance mechanisms may limit treatment benefit, and their detection is expensive. The aim of this retrospective study was to investigate the usability of inflammatory-nutritional indices and hemoglobin, albumin, lymphocyte and platelet (HALP) scores for predicting survival in patients with metastatic NSCLCs with driver mutations undergoing first-line treatment with tyrosine kinase inhibitors (TKIs).Patients & methods: Ninety-two patients using TKIs for metastatic disease with driver mutations were followed up in our center from December 2018 to May 2024. We retrospectively investigated the effects on progression-free survival (PFS) and overall survival (OS) by calculating inflammatory-nutritional indices and HALP scores using pre-treatment laboratory values.Results: Higher plate-let-to-lymphocyte ratios (PLRs) were associated with shorter PFS, whereas a higher prognostic nutritional index (PNI) predicted longer PFS. Similarly, high HALP and PNI scores were significantly associated with longer OS, while lower platelet-to-lymphocyte ratio (PLR), systemic immune inflammatory index (SII) and systemic inflammation response index (SIRI) were linked to improved OS. Multivariate analysis identified only SII as an independent OS prognostic factor (OR = 7.182, p = 0.003).Conclusions: HALP score, PLR, SII, PNI and SIRI may serve as potential prognostic biomarkers in NSCLC patients with driver mutations treated with first-line TKIs.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"847-855"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potentialities and challenges of liquid biopsy in clinical cancer management. 液体活检在临床癌症治疗中的潜力和挑战。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-10-06 DOI: 10.1080/17520363.2025.2564057

Negin Ghiyasimoghaddam, Navidreza Shayan, Nima Ameli, Mohammadhasan Baghbani, Hanieh Alsadat Mirkatuli, Amir Attaran Khorasani, Nooshin Mohtasham

{"title":"Potentialities and challenges of liquid biopsy in clinical cancer management.","authors":"Negin Ghiyasimoghaddam, Navidreza Shayan, Nima Ameli, Mohammadhasan Baghbani, Hanieh Alsadat Mirkatuli, Amir Attaran Khorasani, Nooshin Mohtasham","doi":"10.1080/17520363.2025.2564057","DOIUrl":"10.1080/17520363.2025.2564057","url":null,"abstract":"Assessment of biomarkers through liquid biopsy, accompanied by low invasiveness, provides a more comprehensive analysis of the genetic profile of tumors, a deeper understanding of cancer mechanisms, the capacity for repeated testing over time, a short processing time, ease of obtaining, and economic benefits, making it easier to monitor diseases compared to tissue biopsy. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), exosomes, non-coding RNAs, and metabolites provide precise and timely strategies for managing cancer patients. The main challenges are the low concentration of analytes isolated from liquid biopsies, the development of assays with both high sensitivity and specificity, and the lack of clear and comprehensive guidelines for assays, which further complicate the standardization process. Combined detection, including both CTCs and ctDNA assessment in circular bodies, provides valuable information at different stages of the tumor, despite the heterogeneity of tumor cells, for prognosis, dynamic monitoring, and mutation detection. In addition, the combination of biofluid biomarkers and artificial intelligence can enhance the accuracy and efficiency of liquid biopsy, improve real-time monitoring of tumor procedures and treatment responses, and provide precision medicine. This review examines the challenges in standardizing biofluid assays and explores potential solutions to achieve more consistent clinical outcomes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"895-908"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer. 评论：血浆来源的circALG8和circCAMTA1可作为非小细胞肺癌早期诊断的一个指标。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-10-10 DOI: 10.1080/17520363.2025.2573580

Guo-Ming Zhang

引用次数: 0