Biomarkers in medicine最新文献

Correlation between serum GFAP and 3-NT levels and the degree of neuronal injury in patients with glioma after surgery, and its diagnostic value. 脑胶质瘤术后患者血清GFAP和3-NT水平与神经元损伤程度的相关性及其诊断价值

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1080/17520363.2025.2559432

Jiaode Jiang, Feng Liu

{"title":"Correlation between serum GFAP and 3-NT levels and the degree of neuronal injury in patients with glioma after surgery, and its diagnostic value.","authors":"Jiaode Jiang, Feng Liu","doi":"10.1080/17520363.2025.2559432","DOIUrl":"10.1080/17520363.2025.2559432","url":null,"abstract":"Objective: To investigate the correlation between postoperative serum glial fibrillary acidic protein (GFAP) and 3-nitrotyrosine (3-NT) levels and neuronal injury severity in glioma patients.Methods: 150 glioma patients were enrolled, with clinical baseline and pathological data recorded (age, sex, etc.). Neuronal injury was assessed using the National Institutes of Health Stroke Scale (NIHSS) postoperatively, categorizing patients into mild (NIHSS 1 ~ 4, n = 54) and moderate-to-severe (NIHSS ≥5, n = 96) groups. Serum GFAP and 3-NT levels were measured three days post-surgery via ELISA. Correlations with NIHSS were analyzed with Spearman's test. Patients were also stratified by median biomarker levels. Multivariate logistic regression identified severity risk factors. Receiver operating characteristic (ROC) curves evaluated diagnostic value.Results: GFAP and 3-NT levels were higher in the moderate-to-severe group (p < 0.001) and positively correlated with NIHSS scores (GFAP: r = 0.552; 3-NT: r = 0.545). Higher biomarker levels were significantly associated with worse injury (p < 0.001). Both were independent risk factors for severity. Combining GFAP and 3-NT predicted severity significantly better than either alone (p < 0.001).Conclusion: Postoperative serum GFAP and 3-NT levels correlate positively with neuronal injury severity in glioma patients. Their combination provides high diagnostic value for assessing postoperative injury severity.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"837-846"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of inflammatory-nutritional indexes and HALP score in advanced stage NSCLC treated with first-line TKI. 炎症营养指标和HALP评分在一线TKI治疗晚期NSCLC中的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-13 DOI: 10.1080/17520363.2025.2560797

Ali Ogul, Ali Alper Solmaz, Ilhan Birsenogul, Yunus Coskun, Mahmut Bakır Koyuncu, Abdullah Evren Yetisir, Mahmut Buyuksimsek, Mert Tohumcuoglu, Mehmet Turker, Mustafa Gurbuz, Berna Bozkurt Duman, Timucin Cil

{"title":"Prognostic value of inflammatory-nutritional indexes and HALP score in advanced stage NSCLC treated with first-line TKI.","authors":"Ali Ogul, Ali Alper Solmaz, Ilhan Birsenogul, Yunus Coskun, Mahmut Bakır Koyuncu, Abdullah Evren Yetisir, Mahmut Buyuksimsek, Mert Tohumcuoglu, Mehmet Turker, Mustafa Gurbuz, Berna Bozkurt Duman, Timucin Cil","doi":"10.1080/17520363.2025.2560797","DOIUrl":"10.1080/17520363.2025.2560797","url":null,"abstract":"Aim: In metastatic Non-small cell lung cancer (NSCLC) with driver mutations, resistance mechanisms may limit treatment benefit, and their detection is expensive. The aim of this retrospective study was to investigate the usability of inflammatory-nutritional indices and hemoglobin, albumin, lymphocyte and platelet (HALP) scores for predicting survival in patients with metastatic NSCLCs with driver mutations undergoing first-line treatment with tyrosine kinase inhibitors (TKIs).Patients & methods: Ninety-two patients using TKIs for metastatic disease with driver mutations were followed up in our center from December 2018 to May 2024. We retrospectively investigated the effects on progression-free survival (PFS) and overall survival (OS) by calculating inflammatory-nutritional indices and HALP scores using pre-treatment laboratory values.Results: Higher plate-let-to-lymphocyte ratios (PLRs) were associated with shorter PFS, whereas a higher prognostic nutritional index (PNI) predicted longer PFS. Similarly, high HALP and PNI scores were significantly associated with longer OS, while lower platelet-to-lymphocyte ratio (PLR), systemic immune inflammatory index (SII) and systemic inflammation response index (SIRI) were linked to improved OS. Multivariate analysis identified only SII as an independent OS prognostic factor (OR = 7.182, p = 0.003).Conclusions: HALP score, PLR, SII, PNI and SIRI may serve as potential prognostic biomarkers in NSCLC patients with driver mutations treated with first-line TKIs.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"847-855"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and significance of TNFSF12/TWEAK, CD163 in monocytes of patients with newly diagnosed rheumatoid arthritis. 新诊断类风湿性关节炎患者单核细胞中TNFSF12/TWEAK、CD163的表达及意义

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1080/17520363.2025.2562556

Tingting Zeng, Lulu Zeng, Qianbin Dai, Yao Zhou, Qing Luo, Lu Zhang

{"title":"Expression and significance of TNFSF12/TWEAK, CD163 in monocytes of patients with newly diagnosed rheumatoid arthritis.","authors":"Tingting Zeng, Lulu Zeng, Qianbin Dai, Yao Zhou, Qing Luo, Lu Zhang","doi":"10.1080/17520363.2025.2562556","DOIUrl":"10.1080/17520363.2025.2562556","url":null,"abstract":"Aim: A retrospective study was designed to compare the expression levels of TNF superfamily member 12 (TNFSF12), which encodes the protein TNF-like weak inducer of apoptosis (TWEAK), and CD163 in peripheral blood monocytes between rheumatoid arthritis (RA) patients and controls, and to correlate their expression with clinical parameters to investigate their potential association with RA.Materials & methods: RT-qPCR method was used to determine gene expression of TNFSF12 and CD163 in patients with RA, ankylosing spondylitis (AS) and healthy controls (HC). ROC curve, Pearson correlation analysis, and western blot were used to access the diagnostic performance of TNFSF12/TWEAK and CD163, analyze their correlation with other clinical parameters in RA, and evaluate the protein expression of TWEAK and CD163 in RA.Results: TNFSF12 and CD163 in RA patients were higher expressed compared with AS and HC; they were helpful to identify RA patients from controls, with area under ROC curve (AUC) being 0.813 and 0.826, respectively, and correlated with ESR and CRP. TWEAK and CD163 in monocytes from RA were significantly upregulated compared with controls.Conclusion: TNFSF12 and CD163 gene higher expressed in RA patients and related with therapeutic response and inflammation status, can be used as reference index for RA diagnosis and disease monitoring.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"857-865"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil percentage-to-albumin ratio as a predictor of In-hospital mortality in infective endocarditis. 中性粒细胞百分比-白蛋白比作为感染性心内膜炎住院死亡率的预测因子。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-19 DOI: 10.1080/17520363.2025.2562554

Muhammet Mucahit Tiryaki, Cemalettin Yilmaz, Huseyin Sefa Ince, Banu Karaca, Fatma Kayaalti Esin, Tuncay Kiris

{"title":"Neutrophil percentage-to-albumin ratio as a predictor of In-hospital mortality in infective endocarditis.","authors":"Muhammet Mucahit Tiryaki, Cemalettin Yilmaz, Huseyin Sefa Ince, Banu Karaca, Fatma Kayaalti Esin, Tuncay Kiris","doi":"10.1080/17520363.2025.2562554","DOIUrl":"10.1080/17520363.2025.2562554","url":null,"abstract":"Background: Infective endocarditis (IE) remains a life-threatening condition despite treatment advances. Early identification of high-risk patients is essential. The neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory marker linked to poor outcomes in various diseases, but its prognostic value in IE remains unclear. This study aimed to investigate the association between NPAR and in-hospital mortality in patients with IE.Methods: We retrospectively analyzed 263 patients diagnosed with IE between January 2009 and January 2024 at a tertiary care center. Clinical, laboratory, and echocardiographic data were collected. NPAR was calculated as (Neutrophil %/Albumin [g/dL]). Predictors of mortality were identified using LASSO-based logistic regression, and a nomogram was constructed to illustrate predictive performance.Results: In-hospital mortality occurred in 59 patients (22.4%). NPAR was significantly higher among non-survivors (median: 0.335 vs. 0.228, p < 0.001). High NPAR ( >0.274) was independently associated with in-hospital mortality (OR: 6.70, 95% CI: 3.07-15.61, p < 0.001), along with large vegetation and diabetes mellitus. High NPAR showed good discriminative power (AUC = 0.72, 95% CI: 0.66-0.79, p < 0.001).Conclusion: High NPAR was an independent predictor of in-hospital mortality in IE and may serve as a simple, cost-effective biomarker for early risk stratification.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"867-874"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in clinical studies evaluating neurofilament light chain as a biomarker. 评价神经丝轻链作为生物标志物的临床研究趋势。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-16 DOI: 10.1080/17520363.2025.2562546

Sydney Stern, Kristin Jamenis, Sreedharan Sabarinath, Shawna L Weis, Robert Schuck, Michael Pacanowski

{"title":"Trends in clinical studies evaluating neurofilament light chain as a biomarker.","authors":"Sydney Stern, Kristin Jamenis, Sreedharan Sabarinath, Shawna L Weis, Robert Schuck, Michael Pacanowski","doi":"10.1080/17520363.2025.2562546","DOIUrl":"10.1080/17520363.2025.2562546","url":null,"abstract":"Introduction: The use of biomarkers as surrogate endpoints, supported by strong mechanistic, epidemiologic, and/or clinical data, provides drug development programs with endpoints that predict clinical benefit and may be more sensitive to drug effects than clinical endpoints. Neurofilament light chain (NfL) is a marker of neuroaxonal injury that has emerged as a promising biomarker for neurodegenerative diseases.Methods: We identified Investigational New Drug programs submitted to the U.S. Food and Drug Administration between 2005-2024 that proposed to use NfL as a pharmacodynamic biomarker, biomarker for patient selection or stratification, and/or surrogate endpoint for accelerated approval.Results: A total of 50 programs were identified with most from the last five years. Of the 50 programs, 94% (n = 47) proposed NfL as a pharmacodynamic biomarker, 8% (n = 4) for patient selection, 52% (n = 26) for patient stratification, and 20% (n = 10) as a surrogate endpoint. Of the programs evaluating NfL as a pharmacodynamic biomarker with available data on NfL levels (n = 21), approximately 50% reported NfL changes that correlated with drug exposure.Conclusion: This analysis highlights the important role that NfL plays in clinical trials and identifies future areas of research and study design considerations to strengthen the support of NfL as a biomarker.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"813-823"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From molecules to meaning: non-coding RNAs as biomarkers in obstructive sleep apnea. 从分子到意义：非编码rna作为阻塞性睡眠呼吸暂停的生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-22 DOI: 10.1080/17520363.2025.2562551

Manuel Sánchez-de-la-Torre, Clémentine Puech, David de Gonzalo-Calvo

引用次数: 0

Prognostic impact of Naples prognostic score on long-term mortality in non-ST-elevation myocardial infarction. 那不勒斯预后评分对非st段抬高型心肌梗死长期死亡率的影响。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-08-15 DOI: 10.1080/17520363.2025.2548759

Berhan Keskin, Aykun Hakgor, Fatih Erkam Olgun, Ahmet Berk Duman, Beytullah Cakal, Seda Tanyeri, Barkın Kultursay, Canan Elif Yildiz, Emir Dervis, Ibrahim Oguz Karaca, Bilal Boztosun

{"title":"Prognostic impact of Naples prognostic score on long-term mortality in non-ST-elevation myocardial infarction.","authors":"Berhan Keskin, Aykun Hakgor, Fatih Erkam Olgun, Ahmet Berk Duman, Beytullah Cakal, Seda Tanyeri, Barkın Kultursay, Canan Elif Yildiz, Emir Dervis, Ibrahim Oguz Karaca, Bilal Boztosun","doi":"10.1080/17520363.2025.2548759","DOIUrl":"10.1080/17520363.2025.2548759","url":null,"abstract":"Background: The Naples Prognostic Score (NPS) is a composite index of inflammation and nutritional status. This study aimed to evaluate the prognostic value of NPS for long-term all-cause mortality in non-ST-elevation myocardial infarction (NSTEMI).Methods: In this study, 396 consecutive NSTEMI patients who underwent coronary angiography/percutaneous coronary intervention between 1 August 2023, and 31 July 2024, were included. Patients were stratified into low (NPS: 0-1), intermediate (NPS: 2), and high (NPS: 3-4) risk groups. Median follow-up was 433 days. Univariate logistic regression identified predictors of longterm mortality. These were then entered into LASSOpenalized logistic regression for variable selection. Multivariate Cox proportional hazards models assessed the independent predictors of long-term mortality, adjusting for SYNTAX score, hemoglobin, sodium, age, and left ventricular ejection fraction (LVEF).Results: High-risk NPS patients (n = 91) had higher long-term mortality (17.6%) compared with intermediate-risk (3.7%) and low-risk (3.5%) groups (p < 0.001). In the adjusted Cox model, high-risk NPS independently predicted long-term mortality (HR:3.79; 95% CI 1.55-9.27; p = 0.003), whereas neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were not significant when substituted for NPS.Conclusion: In NSTEMI patients, NPS independently predicts long-term all-cause mortality beyond traditional risk markers and outperforms isolated inflammatory indices such as NLR and CRP.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"825-835"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Association is not prediction - choosing the right tools for diagnostic evidence synthesis. 给编辑的信：联合不是预测——选择正确的工具来合成诊断证据。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-09-01 Epub Date: 2025-09-15 DOI: 10.1080/17520363.2025.2561397

Javier Arredondo Montero

引用次数: 0

Serum inflammatory and coagulation markers in GBS infection and adverse pregnancy outcomes. GBS感染和不良妊娠结局的血清炎症和凝血标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-22 DOI: 10.1080/17520363.2025.2538429

Lin Li, Xiaoying Wang, Dan Li, Zhenfang Liu

{"title":"Serum inflammatory and coagulation markers in GBS infection and adverse pregnancy outcomes.","authors":"Lin Li, Xiaoying Wang, Dan Li, Zhenfang Liu","doi":"10.1080/17520363.2025.2538429","DOIUrl":"https://doi.org/10.1080/17520363.2025.2538429","url":null,"abstract":"Objective: To investigate the relationship between Group B Streptococcus (GBS) infection in pregnant women and adverse pregnancy events (APEs), as well as serum inflammatory factors (IFs) and coagulation parameters.Methods: A retrospective analysis was conducted on 2,200 late-pregnancy women who delivered at Maternal and Child Health Hospital from March 2020 to January 2023. Data on GBS infection, serotyping, immunofluorescence, coagulation parameters, and APEs were collected. APE incidence was compared between groups, and logistic regression was performed to analyze inflammatory factors and coagulation parameters in GBS-positive women with and without APEs.Results: Among the participants, 593 (26.95%) were GBS-positive, and 1,607 (73.05%) were GBS-negative. The GBS-positive group had significantly higher rates of preterm birth, intrauterine infection, premature rupture of membranes, placental abruption, postpartum hemorrhage, and meconium-stained amniotic fluid compared to the GBS-negative group (p < 0.05). Logistic regression identified white blood cell count, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6 (IL-6), interleukin-1β, procalcitonin, and fibrinogen as independent risk factors for APEs (p < 0.05).Conclusion: GBS infection increases the risk of adverse pregnancy events and is closely associated with alterations in inflammatory and coagulation markers.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic immune-inflammation index as a biomarker for stroke prognosis: insights from a multi-time point analysis. 全身免疫炎症指数作为脑卒中预后的生物标志物：来自多时间点分析的见解。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2025-08-01 Epub Date: 2025-08-08 DOI: 10.1080/17520363.2025.2540760

Yanan Wang, Jiaojiao Wang, Fengmei Tian, Mengyun Peng, Xiaomin Ma, Dahong Zheng, Xiaoxiao Li, Jingya Jiao, Liping Zheng, Zhengbao Zhu, Shu Ji, Daoxia Guo

{"title":"Systemic immune-inflammation index as a biomarker for stroke prognosis: insights from a multi-time point analysis.","authors":"Yanan Wang, Jiaojiao Wang, Fengmei Tian, Mengyun Peng, Xiaomin Ma, Dahong Zheng, Xiaoxiao Li, Jingya Jiao, Liping Zheng, Zhengbao Zhu, Shu Ji, Daoxia Guo","doi":"10.1080/17520363.2025.2540760","DOIUrl":"10.1080/17520363.2025.2540760","url":null,"abstract":"Aims: This study aimed to investigate the association between the systemic immune-inflammation index (SII) and prognosis trajectories in ischemic stroke(IS).Methods: Patients from two tertiary hospitals in Suzhou were included in this study. SII was calculated as neutrophils×platelets/lymphocytes, and patients were categorized into quartiles based on SII values. Latent class growth modeling (LCGM) was employed to describe the trajectories of modified Rankin Scale (mRS) at different time points.Logistic regression models were used to evaluate the association between SII quartiles and prognosis trajectories at multiple time points (14 days, 1 month, 3 months, 6 months)and prognostic trajectories.Results: Patients in the highest quartile (Q4) of SII had a significantly higher risk of adverse outcomes compared to those in the lowest quartile (Q1). A three-group model was identified as the optimal trajectory model for stroke prognosis. SII was associated with 4.06-fold increased odds (95% CI: 1.64-10.08) of unfavorable prognosis trajectories. Per standard deviation increase in the logarithmic SII, the odds of unfavorable prognosis trajectories were 1.64 (95% CI: 1.18-2.29).Conclusions: Baseline SII is significantly associated with unfavorable outcome trajectories across multiple time points in IS. These findings highlight the potential value of SII as a predictive biomarker for sequential prognosis in stroke patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"697-705"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0