Biomarkers in medicine最新文献

Implications of Raftlin in different diseases: from molecular biology to diagnostic value. Raftlin在不同疾病中的意义：从分子生物学到诊断价值。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1080/17520363.2025.2453411

Fugui Lin, Li Yan, Xiumei Yuan, Xingwen Yang, Xiaoyan Yang, Yang Yang, Li Ma, Lianhua Wei, Dehong Li

{"title":"Implications of Raftlin in different diseases: from molecular biology to diagnostic value.","authors":"Fugui Lin, Li Yan, Xiumei Yuan, Xingwen Yang, Xiaoyan Yang, Yang Yang, Li Ma, Lianhua Wei, Dehong Li","doi":"10.1080/17520363.2025.2453411","DOIUrl":"10.1080/17520363.2025.2453411","url":null,"abstract":"Raftlin (raft-linking) protein is an essential component of the lipid raft structure and plays a crucial role in B and T cell signaling pathways. It facilitates B cell receptor (BCR) signaling by promoting calcium mobilization and tyrosine phosphorylation in the cells while colocalizing with BCR on the cell membrane. Interestingly, Raftlin is internalized in lipopolysaccharide-stimulated T cells by colocalization with Toll-like receptor 4 (TLR4), wherein it exerts a similar role as in B cells. The protein also effectuates poly(I:C) internalization into TLR3-positive endosomes in dendritic and epithelial cells through clathrin binding, thereby affecting interferon-β production. In addition, Raftlin controls the vascular endothelial cells and participates in cell growth and proliferation. Recent studies have indicated Raftlin to be a novel biomarker for the diagnosis due to its upregulated expression in malignant diseases. In this integrated study, we present the biological functions of Raftlin and its expression to provide a theoretical basis for the prevention, diagnosis, and treatment of various diseases.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"91-99"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-bilirubin score: a promising predictor of postoperative distant metastasis in patients with colorectal cancer. 白蛋白-胆红素评分：结直肠癌患者术后远处转移的一个有希望的预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1080/17520363.2025.2455928

Xiuying Shi, Shuyi Zhang, Baijun Bao, Hui Cong, Xiaomin Lu, Aijun Shi

{"title":"Albumin-bilirubin score: a promising predictor of postoperative distant metastasis in patients with colorectal cancer.","authors":"Xiuying Shi, Shuyi Zhang, Baijun Bao, Hui Cong, Xiaomin Lu, Aijun Shi","doi":"10.1080/17520363.2025.2455928","DOIUrl":"10.1080/17520363.2025.2455928","url":null,"abstract":"Aim: The objective of this study was to investigate the prognostic significance of the preoperative serum albumin-bilirubin (ALBI) score in patients with colorectal cancer (CRC).Methods: Preoperative ALBI data from 1506 CRC patients were categorized into high-value and low-value groups, and the clinicopathological characteristics of these groups were compared. A Cox proportional hazards regression model was employed to investigate the risk factors associated with distant metastasis. The Kaplan-Meier method and log-rank test were utilized to analyze the relationship between ALBI scores and 5-year distant metastasis-free survival (DMFS).Results: The incidence of distant metastasis in group B (ALBI ≥ -2.4) was significantly higher at 28.81% compared to group A (ALBI < -2.4), which had an incidence of 23.36% (p = 0.018). ALBI score ≥ -2.4 was identified as an independent risk factor for postoperative distant metastasis of CRC (HR = 1.251, 95%CI: 1.021-1.533, p = 0.031). The incidence of 5-year DMFS was significantly lower in the ALBI ≥ -2.4 group compared to that observed in the ALBI < -2.4 group (χ2 = 5.97, p = 0.015, log-rank test).Conclusion: The ALBI score of ≥ -2.4 emerges as an independent risk factor for the occurrence of distant metastases following CRC surgery.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"73-79"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1080/17520363.2025.2455924

X H Chen, L Li, S Y Ma, C Q Ling, J Q Lai, H J Yao, W B Guo, Y Yang, Y Zhang, W J Lin, F Z He

{"title":"Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes.","authors":"X H Chen, L Li, S Y Ma, C Q Ling, J Q Lai, H J Yao, W B Guo, Y Yang, Y Zhang, W J Lin, F Z He","doi":"10.1080/17520363.2025.2455924","DOIUrl":"10.1080/17520363.2025.2455924","url":null,"abstract":"Objective: This study aims to explore the association between arginase 1 (ARG1) genetic variation and susceptibility to type 2 diabetes (T2DM) vascular complications, a primary cause of morbidity and mortality in diabetics.Methods: ARG1, a risk gene for cardiovascular disease, was identified from GEO datasets GSE22255 and GSE58294. The ENCODE database identified four candidate single-nucleotide polymorphism (SNP) loci. Nine hundred ninety-two T2DM patients underwent SNP genotyping, and relevant biochemical markers were tested. Logistic regression analysis calculated the odds ratio (OR) and 95% confidence interval (CI) between ARG1 SNP and diabetic vascular complications.Results: Out of 985 patients, 250 had CHD, with the TTTG group accounting for 64/250. This group showed a significant reduction in CHD risk (non-TTTG factor-adjusted OR = 1.61, 95% CI: 1.14-2.29, p = 0.008). The combination of the TTTG group, age, central obesity, and hypertension better predicted CHD risk (Area under the curve = 0.72, p < 0.001).Conclusions: ARG1 polymorphisms significantly impact vascular complications in T2DM patients, implying that ARG1 genetic variation may be a potential prevention and treatment target.Trial registration: ChiCTR1800015661.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"63-72"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum vitamin B12 concentrations in a patient with pancreatic exocrine insufficiency.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI: 10.1080/17520363.2025.2455927

Richard Makins, Emma Stevenson, Agata Sobczyńska-Malefora

引用次数: 0

Complement 3 and 4 impact in osteoarthritis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-02-02 DOI: 10.1080/17520363.2024.2409062

Lifang Wang

引用次数: 0

The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-31 DOI: 10.1080/17520363.2025.2459596

Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin

{"title":"The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis.","authors":"Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin","doi":"10.1080/17520363.2025.2459596","DOIUrl":"https://doi.org/10.1080/17520363.2025.2459596","url":null,"abstract":"Aim: Ulcerative colitis (UC) is an incurable disease represented by relapse and remission. Noninvasive biomarkers are required to predict disease activation. This study aimed to identify noninvasive biomarkers, such as the c-reactive protein-albumin (CRP/ALB) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), that might forecast disease activation in UC.Methods: This retrospective study included 443 participants: 192 patients with active UC, 166 in remission, and 85 healthy controls. Mayo Endoscopic Subscore was employed to assess endoscopic disease activity. Serum CRP, erythrocyte sedimentation rate (ESR), ALB levels, and complete blood count characteristics were documented. Three ratios of inflammation-related indicators were identified as CRP/ALB, PLR, and NLR.Results: A positive correlation was found between ESR, CRP, neutrophil count, platelet count, levels of CRP/ALB, PLR, NLR, and endoscopic activity. The CRP/ALB ratio demonstrated more efficacy than the NLR and PLR in differentiating the UC patients from the controls (p = 0.007, p = 0.003, respectively) and the active group from the remission group (p < 0.001, p < 0.001, respectively). Regression analysis revealed that the CRP/ALB was significantly able to distinguish active UC from the remission group and the controls (p < 0.001, p < 0.001, respectively).Conclusion: The CRP/ALB ratio could be useful as an independent predictive biomarker for disease activity in UC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-29 DOI: 10.1080/17520363.2025.2459590

Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek

{"title":"The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI.","authors":"Veysel Ozan Tanık, Çağatay Tunca, Kamuran Kalkan, Ahmet Kivrak, Bülent Özlek","doi":"10.1080/17520363.2025.2459590","DOIUrl":"https://doi.org/10.1080/17520363.2025.2459590","url":null,"abstract":"Objective: Newly diagnosed AF (NOAF) associated with acute STEMI holds significant relevance in clinical practice. This study seeks to assess the role of the monocyte to HDL-C ratio (MHR) in predicting NOAF in these patients.Methods: Between July 2017 and May 2018, 663 patients who underwent primary PCI for STEMI were retrospectively analyzed. NOAF was identified in 34 patients (5.1%), and this group was compared with those without AF.Results: The NOAF group experienced a longer hospitalization duration and a higher mortality rate (11.8 vs. 4.3%, p = 0.044) compared to the non-AF group. In a multivariable analysis, increased MHR (OR: 1.413, 95% CI: 1.203-1.657, p = 0.005), advanced age, decreased LVEF, Killip class 2-4, diabetes mellitus, hypertension, and left atrial enlargement emerged as independent predictors for the development of NOAF in STEMI. ROC curve analysis revealed that MHR values exceeding 26.54 strongly predict NOAF, achieving sensitivity and specificity above 70% (AUC: 0.768, 95%CI: 0.734-0.801, p < 0.001).Conclusion: The present study revealed that increased MHR robust indicator for NOAF in STEMI patients and can be easily assessed in clinical practice. Incorporating MHR alongside established traditional risk factors may enhance the identification of patients at risk for AF in those with STEMI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncertainty in the diagnosis and prognosis of adult-onset Still's disease.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-28 DOI: 10.1080/17520363.2025.2459591

Ashok Kumar Pannu

引用次数: 0

HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-27 DOI: 10.1080/17520363.2025.2455925

Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi

{"title":"HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.","authors":"Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi","doi":"10.1080/17520363.2025.2455925","DOIUrl":"https://doi.org/10.1080/17520363.2025.2455925","url":null,"abstract":"Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.Methods: We searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses.Results: The meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8-10.8, p = 0.00). Considerable heterogeneity was observed (Q-value: 1174.2, df = 9, I2 = 99.2%, p = 0.00). Subgroup analyses indicated significant associations in tissue samples and studies from the USA and China. Meta-regression revealed that study design and country contributed to the observed heterogeneity, with no significant publication bias detected.Conclusion: This analysis confirms the significant link between HOTAIR expression and GBM, highlighting HOTAIR as a potential therapeutic target and biomarker. Further research is necessary to clarify the biological mechanisms involved in this association.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy. 外泌体PD-L1在癌症治疗中的临床病理和预后意义。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1080/17520363.2024.2448117

Shunqin Hu, Fengchang Huang, Xiuying Li

{"title":"Clinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy.","authors":"Shunqin Hu, Fengchang Huang, Xiuying Li","doi":"10.1080/17520363.2024.2448117","DOIUrl":"10.1080/17520363.2024.2448117","url":null,"abstract":"Aim: The exosomal programmed death ligand-1(exoPD-L1) has recently become a topic of interest in the field of oncology. But the prognostic role of exoPD-L1 in cancer patients is inconsistent across previous studies. Therefore, a quantitative meta-analysis was performed to evaluate the prognostic and clinicopathological value of exoPD-L1 in cancer patients.Materials and methods: Twenty eligible studies were included in this study. The relationship between baseline level of exoPD-L1 and clinicopathological features, therapeutic response, overall survival (OS) and progression-free survival (PFS) was evaluated.Results: Pooled analysis indicated that high level of exoPD-L1 was significantly associated with higher tumor stage, positive lymph node metastasis, and advanced TNM stage. Elevated exoPD-L1 was associated with short OS [HR = 1.80 (1.27-2.55), p = 0.001]. In the subgroup analysis, high-level exoPD-L1 was consistently associated with poor OS in sample source, detection method, and lymphoma patients. Moreover, elevated exoPD-L1 was predictive of worse PFS [HR = 1.28 (1.13-4.18), p = 0.000]. In addition, a striking difference between cancer patients and healthy donors was observed in the level of exoPD-L1.Conclusion: exoPD-L1 is an original and effective liquid biomarker for cancer patients. However, large-scale, prospective investigations are still needed to confirm our findings.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"19 2","pages":"51-57"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0