Biomarkers in medicine最新文献

Association between IRAK1 gene rs1059703 polymorphism and rheumatoid arthritis risk. IRAK1基因rs1059703多态性与类风湿关节炎风险的相关性

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-10-20 DOI: 10.1080/17520363.2026.2750231

Zheng Wang, Junhong Li

{"title":"Association between IRAK1 gene rs1059703 polymorphism and rheumatoid arthritis risk.","authors":"Zheng Wang, Junhong Li","doi":"10.1080/17520363.2026.2750231","DOIUrl":"https://doi.org/10.1080/17520363.2026.2750231","url":null,"abstract":"Objectives: This meta-analysis aimed to investigate the relationship between interleukin-1 receptor-associated kinase (IRAK1) gene rs1059703 and rheumatoid arthritis (RA) risk.Methods: The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated. Funnel plot with trim-and-fill analysis was used for publication bias investigation.Results: IRAK1 gene rs1059703 was not significantly associated with RA risk under dominant genetic model (OR = 1.47, 95%CI = 0.96-2.24, p = 0.071), recessive genetic model (OR = 1.14, 95%CI = 0.92-1.40, p = 0.2258), allele genetic model (OR = 1.29, 95%CI = 0.95-1.75, p = 0.0878), and codominant genetic model (OR = 1.33, 95%CI = 0.82-2.15, p = 0.2125). Subgroup analysis also suggested that IRAK1 gene rs1059703 polymorphism was correlated with RA risk under dominant genetic model (I2 = 80.9%, PQ < 0.0001, OR = 1.77, 95%CI = 1.12-2.79, p = 0.014) and allele model (I2 = 79.6%, PQ = 0.0002, OR = 1.45, 95%CI = 1.05-2.00, p = 0.026) in Caucasian. Sensitivity analysis indicated that there was no significant change in the combined OR. No publication bias was observed.Conclusion: A statistically significant association between IRAK1 rs1059703 and RA risk was observed in Caucasian populations, but not in Asian populations with the available power under the current sample size. The apparent Caucasian association observed in the full dataset was not sustained after restricting analyses to HWE-compliant studies, where only a single Caucasian study remained.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating extracellular vesicles as biomarkers of cardiac fibrosis: promise, pitfalls, and the path to clinical validation. 循环细胞外囊泡作为心脏纤维化的生物标志物：前景、缺陷和临床验证之路。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-10-19 DOI: 10.1080/17520363.2026.2749632

Tomoko Kikawa, Nao Nishida-Aoki, Akihiko Okamura, Shungo Hikoso, Takahiro Ochiya

引用次数: 0

Development and validation of a multibiomarker model for 12-month adverse outcomes in acute heart failure. 急性心力衰竭12个月不良结局的多生物标志物模型的开发和验证。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-10-14 DOI: 10.1080/17520363.2026.2747978

YuLin Liu, KeKe Ding, Bing Zhao, ZiQiu Tang, XiZhen Fan, HongQi Li, Li Chen

{"title":"Development and validation of a multibiomarker model for 12-month adverse outcomes in acute heart failure.","authors":"YuLin Liu, KeKe Ding, Bing Zhao, ZiQiu Tang, XiZhen Fan, HongQi Li, Li Chen","doi":"10.1080/17520363.2026.2747978","DOIUrl":"https://doi.org/10.1080/17520363.2026.2747978","url":null,"abstract":"Aims: To develop a multibiomarker model for predicting 12-month major adverse cardiovascular events (MACE) in patients with acute heart failure (AHF) and assess incremental value.Materials and methods: This study included 675 patients with AHF, comprising a development cohort (n = 303) and a validation cohort (n = 372). MACE comprised all-cause death or heart failure rehospitalization. Least absolute shrinkage and selection operator Cox regression and multivariable Cox regression were used for model development. Model performance was assessed using discrimination, calibration, decision curve analysis (DCA), and incremental value.Results: The final model included monocyte-to-lymphocyte ratio (MLR), N-terminal pro-B-type natriuretic peptide (NT-proBNP), heparin-binding protein (HBP), and soluble suppression of tumorigenicity 2 (sST2). Harrell's concordance index, the 12-month area under the time-dependent receiver operating characteristic curve (AUC), and Brier score were 0.710, 0.804, and 0.180 in the development cohort and 0.710, 0.760, and 0.203 in the validation cohort, respectively. Calibration demonstrated overall agreement between predicted and observed risks, and DCA suggested potential clinical net benefit. Adding HBP, sST2, and MLR to clinical variables and NT-proBNP increased the 12-month AUC from 0.753 to 0.824.Conclusions: The multibiomarker model showed moderate predictive performance and may support post-discharge risk stratification in patients with AHF.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of CBC-derived systemic inflammation markers with first-episode peritonitis in peritoneal dialysis. cbc来源的全身性炎症标志物与腹膜透析患者首发腹膜炎的相关性

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-10-01 DOI: 10.1080/17520363.2026.2740175

Fang Gao, Lulu Fan, Hongyu Xiang, Rui Zhang, Yangyan Luo

{"title":"Association of CBC-derived systemic inflammation markers with first-episode peritonitis in peritoneal dialysis.","authors":"Fang Gao, Lulu Fan, Hongyu Xiang, Rui Zhang, Yangyan Luo","doi":"10.1080/17520363.2026.2740175","DOIUrl":"https://doi.org/10.1080/17520363.2026.2740175","url":null,"abstract":"Background: Peritoneal dialysis-associated peritonitis (PDAP) remains a major cause of technique failure in peritoneal dialysis (PD) patients. Novel complete blood count-derived inflammatory markers, including the systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI), may provide accessible tools for early PDAP risk prediction.Methods: In this retrospective cohort study, 302 PD patients were stratified according to incident PDAP during follow-up. Restricted cubic splines assessed nonlinear associations. Multivariable logistic regression evaluated independent associations with first-episode PDAP. Receiver operating characteristic curves assessed predictive performance.Results: Baseline SII, SIRI, and AISI levels were significantly higher in the PDAP group than in the non-PDAP group (all p < 0.05). Higher Ln-SII (OR: 3.598; 95% CI: 2.204-5.872), Ln-SIRI (OR: 2.425; 95% CI: 1.584-3.714), and Ln-AISI (OR: 2.007; 95% CI: 1.403-2.871) were independently associated with increased PDAP risk (all p < 0.001). SII showed the highest discriminatory performance among the three markers, with an area under the curve of 0.689. A combined model incorporating SII, SIRI, and AISI achieved an AUC of 0.715.Conclusion: Higher SII, SIRI, and AISI levels were associated with an increased risk of first-episode PDAP. A combined model demonstrates promising predictive accuracy.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified CONUT score integrating C-reactive protein improves prognostic prediction in non-small cell lung cancer. 整合c反应蛋白的改进CONUT评分提高了非小细胞肺癌的预后预测。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-10-01 DOI: 10.1080/17520363.2026.2738766

Xiang-Ting Dai, Xiu-Xiu Li, Xi Zhang, Jia-Xin Huang, Min Yang, Meng Tang, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong

{"title":"Modified CONUT score integrating C-reactive protein improves prognostic prediction in non-small cell lung cancer.","authors":"Xiang-Ting Dai, Xiu-Xiu Li, Xi Zhang, Jia-Xin Huang, Min Yang, Meng Tang, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong","doi":"10.1080/17520363.2026.2738766","DOIUrl":"https://doi.org/10.1080/17520363.2026.2738766","url":null,"abstract":"Aims: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for reliable prognostic indicators. The modified Controlling Nutritional Status (mCONUT) score integrates nutritional and inflammatory parameters. This study evaluated the prognostic value of mCONUT in NSCLC and developed an mCONUT-based nomogram.Patients and methods: This multicenter cohort study included 900 patients with NSCLC. The previously reported CRP-integrated mCONUT scoring system was applied. The prognostic performance of CONUT and mCONUT was compared using concordance index, time-dependent receiver operating characteristic (ROC) curves, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Overall survival (OS) was the primary endpoint. Secondary outcomes included short-term survival, malnutrition, and quality of life. A nomogram was constructed based on independent prognostic factors.Results: During a median follow-up of 33.4 months, 380 deaths occurred. mCONUT showed a higher C-index than CONUT for OS prediction (0.650 vs. 0.605). A high mCONUT score was independently associated with poorer OS (HR = 1.63, 95% CI: 1.28-2.06), increased short-term mortality, an increased risk of malnutrition, and worse quality of life. The mCONUT-based nomogram showed improved discrimination (C-index = 0.727).Conclusion: mCONUT may serve as a supplementary prognostic tool for individualized risk stratification in patients with NSCLC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clarifying the incremental value and implementation boundaries of combined pct and IL-6 in sepsis risk stratification. 明确pct和IL-6联合应用在脓毒症风险分层中的增量价值和实施边界。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-09-28 DOI: 10.1080/17520363.2026.2739532

Qi Yu, Guo-Ming Zhang

引用次数: 0

Serum 14-3-3 eta levels in relation to attack status and amyloidosis in patients with Familial Mediterranean fever. 家族性地中海热患者血清14-3-3 - eta水平与发作状态和淀粉样变的关系

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-09-25 DOI: 10.1080/17520363.2026.2738633

Ayla Avcu, Derya Yıldırım, Ibrahim Vasi, Abdulsamet Erden, Mehmet Akif Öztürk, Abdurrahman Tufan, Hamit Küçük

{"title":"Serum 14-3-3 eta levels in relation to attack status and amyloidosis in patients with Familial Mediterranean fever.","authors":"Ayla Avcu, Derya Yıldırım, Ibrahim Vasi, Abdulsamet Erden, Mehmet Akif Öztürk, Abdurrahman Tufan, Hamit Küçük","doi":"10.1080/17520363.2026.2738633","DOIUrl":"https://doi.org/10.1080/17520363.2026.2738633","url":null,"abstract":"Introduction: Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder characterized by recurrent febrile episodes and complications, including secondary amyloidosis. Protein 14-3-3η, part of a family of intracellular proteins, regulates pyrin activity, inhibiting inflammatory processes. Mutant pyrin disrupts this interaction, activating the inflammasome. Therefore, this study aimed to evaluate serum 14-3-3η levels in relation to attack status and amyloidosis in FMF patients.Methods: A cross-sectional study was conducted with 104 FMF patients diagnosed via Tel Hashomer and PRINTO criteria and 50 healthy controls. Serum 14-3-3η levels were measured using ELISA kits, and statistical analyses were performed using SPSS version 22.0, with significance set at p < 0.05.Results: Groups were similar in age and sex distribution. Serum 14-3-3η levels were significantly lower in FMF patients (median: 1.58 ng/mL) compared to controls (median: 2.33 ng/mL; p < 0.001). No significant differences were observed based on attack status or amyloidosis presence (p = 0.568 and 0.446, respectively).Conclusion: Serum 14-3-3η levels are significantly reduced in FMF patients compared to healthy controls, which may indicate its role in FMF pathogenesis. However, no significant correlation was observed with disease activity or amyloidosis, thus limiting its potential use as a prognostic biomarker for disease progression or complications.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and prognostic value of deregulated miR-493-5p in children with severe pneumonia. miR-493-5p失调控在儿童重症肺炎中的诊断和预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-20 DOI: 10.1080/17520363.2026.2713990

Lili Liu, Lei Han, Huan Zhao, Liying Wang

{"title":"Diagnostic and prognostic value of deregulated miR-493-5p in children with severe pneumonia.","authors":"Lili Liu, Lei Han, Huan Zhao, Liying Wang","doi":"10.1080/17520363.2026.2713990","DOIUrl":"https://doi.org/10.1080/17520363.2026.2713990","url":null,"abstract":"Background: Mounting research has proven that microRNAs (miRNAs) exert critical regulatory functions in the pathological progression of pediatric pneumonia.Aims: To investigate the expression levels and clinical significance of miR-493-5p in children with severe pneumonia.Methods: A total of 125 children diagnosed with severe pneumonia, 100 children with mild pneumonia, and 100 healthy children as normal controls were enrolled in this study. RT-qPCR was adopted to quantify serum miR-493-5p expression levels. ROC curves were plotted to assess its diagnostic efficiency; Kaplan-Meier survival analysis combined with Log-rank test evaluated 28-day prognostic value. LPS-stimulated MRC-5 human lung fibroblast cell model was constructed for in vitro functional experiments to uncover the underlying molecular mechanism of miR-493-5p.Results: Serum miR-493-5p expression was markedly elevated in children with severe pneumonia. ROC analysis validated that serum miR-493-5p possessed satisfactory accuracy for distinguishing severe pneumonia from mild cases. miR-493-5p may target Interferon Regulatory Factor 1 (IRF1) to affect the functions and inflammatory responses of cells in the pneumonia model.Conclusions: Serum miR-493-5p level has significant diagnostic and prognostic value in children with severe pneumonia.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporating the lymphocyte-C-reactive protein ratio into risk stratification for intrahepatic cholangiocarcinoma. 将淋巴细胞- c反应蛋白比值纳入肝内胆管癌的风险分层。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-14 DOI: 10.1080/17520363.2026.2734074

Kaili Xing, Yuhua Wen, Shasha Yuan, Lianghe Lu

{"title":"Incorporating the lymphocyte-C-reactive protein ratio into risk stratification for intrahepatic cholangiocarcinoma.","authors":"Kaili Xing, Yuhua Wen, Shasha Yuan, Lianghe Lu","doi":"10.1080/17520363.2026.2734074","DOIUrl":"10.1080/17520363.2026.2734074","url":null,"abstract":"Objectives: To evaluate the prognostic role of the lymphocyte-C-reactive protein ratio (LCR) in intrahepatic cholangiocarcinoma (ICC) within the TNM framework.Methods: This study enrolled 248 resected ICC patients (low-LCR: 122; high-LCR: 126). A modified TNM (mTNM)system incorporating LCR was proposed.Results: Low LCR was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) by multivariable analysis. Median OS and RFS times were 43.2 and 12.8 months. Patients were stratified into 5 subgroups according to the mTNM staging system: group 1 (n = 67): stage I, LCR > 6000, group 2 (n = 50): stage I, LCR ≤ 6000, group 3 (n = 49): stage II, LCR > 6000, group 4 (n= 49): stage II, LCR ≤ 6000, and group 5 (n = 33): stage III with any LCR. Survival overlaps occurred between groups 2 and 3 (median OS: 49.4 vs 36.6 months; median RFS: 16.2 vs 13.8 months, p > 0.05). Similar overlaps were found for groups 4 and 5. The mTNM system showed improved discriminative ability (AUC: 0.69) over other staging systems (AUC: 0.63-0.65).Conclusion: The mTNM system incorporating LCR provides relatively accurate survival prediction in resected ICC patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"749-757"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated coagulation, platelet, and UACR profiling in type 2 diabetes microvascular complications: a western India study. 2型糖尿病微血管并发症的综合凝血、血小板和UACR分析：一项西印度研究

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI: 10.1080/17520363.2026.2736036

Parth R Goswami, Mehul Kaliya, Garima Anandani, Amit D Sonagra, Kedar Nemivant, Gyanendra Singh, Sagar Dholariya, Vaishali Bhankhodia

{"title":"Integrated coagulation, platelet, and UACR profiling in type 2 diabetes microvascular complications: a western India study.","authors":"Parth R Goswami, Mehul Kaliya, Garima Anandani, Amit D Sonagra, Kedar Nemivant, Gyanendra Singh, Sagar Dholariya, Vaishali Bhankhodia","doi":"10.1080/17520363.2026.2736036","DOIUrl":"10.1080/17520363.2026.2736036","url":null,"abstract":"Aim: To evaluate coagulation parameters, platelet indices, and urinary albumin-to-creatinine ratio (UACR) among 310 participants to assess their type 2 diabetes mellitus (T2DM) microvascular complications.Materials and methods: This cross-sectional study compared healthy controls (n = 103), uncomplicated T2DM (n = 107), and T2DM with microvascular complications (n = 100). Coagulation times (PT, APTT), fibrinogen, mean platelet volume (MPV), and UACR were analyzed using hierarchical logistic regression and ROC curves.Results: A prothrombotic state strongly correlated with disease severity. Median PT (12.5 s to 11.7 s) and APTT (31.0 s to 27.6 s) progressively shortened from controls to the complications group (p < 0.001). Conversely, fibrinogen (2.8 to 3.3 g/L), MPV (8.9 to 9.7 fL), and UACR (1.52 to 4.68 mg/mmol) significantly increased across the same groups. While univariate analysis linked all markers to complications, multivariate modeling confirmed UACR as the marker showing the strongest independent association with microvascular complications (OR = 1.10, 95% CI: 1.06-1.15, p < 0.001). The integrated multivariable model demonstrated good discriminative performance (AUC = 0.857).Conclusion: Although shortened coagulation times and elevated platelet indices are significant indicators of vascular risk, UACR showed the strongest independent association with microvascular complications and may serve as a core marker for risk stratification, while coagulation and platelet indices provide complementary information for identifying high-risk individuals.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"759-770"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0